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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HES4-AFF1 (FusionGDB2 ID:HG57801TG4299)

Fusion Gene Summary for HES4-AFF1

check button Fusion gene summary
Fusion gene informationFusion gene name: HES4-AFF1
Fusion gene ID: hg57801tg4299
HgeneTgene
Gene symbol

HES4

AFF1

Gene ID

57801

4299

Gene namehes family bHLH transcription factor 4AF4/FMR2 family member 1
SynonymsbHLHb42AF4|MLLT2|PBM1
Cytomap('HES4')('AFF1')

1p36.33

4q21.3-q22.1

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor HES-4bHLH factor Hes4class B basic helix-loop-helix protein 42hHES4hairy and enhancer of split 4AF4/FMR2 family member 1ALL1-fused gene from chromosome 4 proteinmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2pre-B-cell monocytic leukemia partner 1proto-oncogene AF4
Modification date2020031320200313
UniProtAcc.

P51825

Ensembl transtripts involved in fusion geneENST00000304952, ENST00000428771, 
ENST00000484667, 
Fusion gene scores* DoF score1 X 2 X 1=219 X 137 X 9=23427
# samples 1141
** MAII scorelog2(1/2*10)=2.32192809488736log2(141/23427*10)=-4.05440515056027
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HES4 [Title/Abstract] AND AFF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHES4(935072)-AFF1(88005272), # samples:2
Anticipated loss of major functional domain due to fusion event.HES4-AFF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HES4-AFF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HES4-AFF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HES4-AFF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across HES4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across AFF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-A3-3373-01AHES4chr1

935072

-AFF1chr4

88005272

+
ChimerDB4KIRCTCGA-A3-3373-01AHES4chr1

935246

-AFF1chr4

88005272

+


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Fusion Gene ORF analysis for HES4-AFF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000304952ENST00000544085HES4chr1

935072

-AFF1chr4

88005272

+
5CDS-5UTRENST00000304952ENST00000544085HES4chr1

935246

-AFF1chr4

88005272

+
5CDS-5UTRENST00000428771ENST00000544085HES4chr1

935072

-AFF1chr4

88005272

+
5CDS-5UTRENST00000484667ENST00000544085HES4chr1

935246

-AFF1chr4

88005272

+
5CDS-intronENST00000304952ENST00000511996HES4chr1

935072

-AFF1chr4

88005272

+
5CDS-intronENST00000304952ENST00000511996HES4chr1

935246

-AFF1chr4

88005272

+
5CDS-intronENST00000428771ENST00000511996HES4chr1

935072

-AFF1chr4

88005272

+
5CDS-intronENST00000484667ENST00000511996HES4chr1

935246

-AFF1chr4

88005272

+
In-frameENST00000304952ENST00000307808HES4chr1

935072

-AFF1chr4

88005272

+
In-frameENST00000304952ENST00000307808HES4chr1

935246

-AFF1chr4

88005272

+
In-frameENST00000304952ENST00000395146HES4chr1

935072

-AFF1chr4

88005272

+
In-frameENST00000304952ENST00000395146HES4chr1

935246

-AFF1chr4

88005272

+
In-frameENST00000428771ENST00000307808HES4chr1

935072

-AFF1chr4

88005272

+
In-frameENST00000428771ENST00000395146HES4chr1

935072

-AFF1chr4

88005272

+
In-frameENST00000484667ENST00000307808HES4chr1

935246

-AFF1chr4

88005272

+
In-frameENST00000484667ENST00000395146HES4chr1

935246

-AFF1chr4

88005272

+
intron-3CDSENST00000428771ENST00000307808HES4chr1

935246

-AFF1chr4

88005272

+
intron-3CDSENST00000428771ENST00000395146HES4chr1

935246

-AFF1chr4

88005272

+
intron-3CDSENST00000484667ENST00000307808HES4chr1

935072

-AFF1chr4

88005272

+
intron-3CDSENST00000484667ENST00000395146HES4chr1

935072

-AFF1chr4

88005272

+
intron-5UTRENST00000428771ENST00000544085HES4chr1

935246

-AFF1chr4

88005272

+
intron-5UTRENST00000484667ENST00000544085HES4chr1

935072

-AFF1chr4

88005272

+
intron-intronENST00000428771ENST00000511996HES4chr1

935246

-AFF1chr4

88005272

+
intron-intronENST00000484667ENST00000511996HES4chr1

935072

-AFF1chr4

88005272

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000428771HES4chr1935072-ENST00000395146AFF1chr488005272+84324811993078959
ENST00000428771HES4chr1935072-ENST00000307808AFF1chr488005272+84134811993075958
ENST00000304952HES4chr1935072-ENST00000395146AFF1chr488005272+82933421382939933
ENST00000304952HES4chr1935072-ENST00000307808AFF1chr488005272+82743421382936932
ENST00000304952HES4chr1935246-ENST00000395146AFF1chr488005272+81972461382843901
ENST00000304952HES4chr1935246-ENST00000307808AFF1chr488005272+81782461382840900
ENST00000484667HES4chr1935246-ENST00000395146AFF1chr488005272+806711682713901
ENST00000484667HES4chr1935246-ENST00000307808AFF1chr488005272+804811682710900

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000428771ENST00000395146HES4chr1935072-AFF1chr488005272+0.0001633530.99983656
ENST00000428771ENST00000307808HES4chr1935072-AFF1chr488005272+0.0001632360.9998367
ENST00000304952ENST00000395146HES4chr1935072-AFF1chr488005272+0.0002302150.99976975
ENST00000304952ENST00000307808HES4chr1935072-AFF1chr488005272+0.0002369340.9997631
ENST00000304952ENST00000395146HES4chr1935246-AFF1chr488005272+0.0003102990.9996897
ENST00000304952ENST00000307808HES4chr1935246-AFF1chr488005272+0.000295440.99970454
ENST00000484667ENST00000395146HES4chr1935246-AFF1chr488005272+0.0003119720.999688
ENST00000484667ENST00000307808HES4chr1935246-AFF1chr488005272+0.000296380.9997036

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Fusion Genomic Features for HES4-AFF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
HES4chr1935071-AFF1chr488005271+2.99E-050.9999701
HES4chr1935245-AFF1chr488005271+1.36E-060.9999987
HES4chr1935071-AFF1chr488005271+2.99E-050.9999701
HES4chr1935245-AFF1chr488005271+1.36E-060.9999987

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for HES4-AFF1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:935072/chr4:88005272)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.AFF1

P51825

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAFF1chr1:935072chr4:88005272ENST00000307808220483_4923461211.0Compositional biasNote=Poly-Ser
TgeneAFF1chr1:935072chr4:88005272ENST00000307808220835_8433461211.0Compositional biasNote=Poly-Ser
TgeneAFF1chr1:935072chr4:88005272ENST00000307808220866_8693461211.0Compositional biasNote=Poly-Pro
TgeneAFF1chr1:935072chr4:88005272ENST00000307808220871_8743461211.0Compositional biasNote=Poly-Ser
TgeneAFF1chr1:935072chr4:88005272ENST00000395146321483_4923531219.0Compositional biasNote=Poly-Ser
TgeneAFF1chr1:935072chr4:88005272ENST00000395146321835_8433531219.0Compositional biasNote=Poly-Ser
TgeneAFF1chr1:935072chr4:88005272ENST00000395146321866_8693531219.0Compositional biasNote=Poly-Pro
TgeneAFF1chr1:935072chr4:88005272ENST00000395146321871_8743531219.0Compositional biasNote=Poly-Ser
TgeneAFF1chr1:935246chr4:88005272ENST00000307808220483_4923461211.0Compositional biasNote=Poly-Ser
TgeneAFF1chr1:935246chr4:88005272ENST00000307808220835_8433461211.0Compositional biasNote=Poly-Ser
TgeneAFF1chr1:935246chr4:88005272ENST00000307808220866_8693461211.0Compositional biasNote=Poly-Pro
TgeneAFF1chr1:935246chr4:88005272ENST00000307808220871_8743461211.0Compositional biasNote=Poly-Ser
TgeneAFF1chr1:935246chr4:88005272ENST00000395146321483_4923531219.0Compositional biasNote=Poly-Ser
TgeneAFF1chr1:935246chr4:88005272ENST00000395146321835_8433531219.0Compositional biasNote=Poly-Ser
TgeneAFF1chr1:935246chr4:88005272ENST00000395146321866_8693531219.0Compositional biasNote=Poly-Pro
TgeneAFF1chr1:935246chr4:88005272ENST00000395146321871_8743531219.0Compositional biasNote=Poly-Ser

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHES4chr1:935072chr4:88005272ENST00000304952-24152_21868222.0Compositional biasNote=Pro-rich
HgeneHES4chr1:935246chr4:88005272ENST00000304952-14152_21836222.0Compositional biasNote=Pro-rich
HgeneHES4chr1:935072chr4:88005272ENST00000304952-24110_14368222.0DomainOrange
HgeneHES4chr1:935072chr4:88005272ENST00000304952-2434_9168222.0DomainbHLH
HgeneHES4chr1:935246chr4:88005272ENST00000304952-14110_14336222.0DomainOrange
HgeneHES4chr1:935246chr4:88005272ENST00000304952-1434_9136222.0DomainbHLH
HgeneHES4chr1:935072chr4:88005272ENST00000304952-24216_21968222.0MotifNote=WRPW motif
HgeneHES4chr1:935246chr4:88005272ENST00000304952-14216_21936222.0MotifNote=WRPW motif


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Fusion Gene Sequence for HES4-AFF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>36203_36203_1_HES4-AFF1_HES4_chr1_935072_ENST00000304952_AFF1_chr4_88005272_ENST00000307808_length(transcript)=8274nt_BP=342nt
GGCCTGAGGCGCGCGCGGGCCTGGAGCCGGGATCCGCCCTAGGGGCTCGGATCGCCGCGCGCTCGCCGCTCGCCCGCCAGCCCGCCCGTG
GTCCGTGGCGGCGCGCTCCACCCGGCACGGGGAGGCGCGGGGCGCACCATGGCCGCAGACACGCCGGGGAAACCGAGCGCCTCGCCGATG
GCAGGAGCGCCGGCCAGCGCCAGCCGGACCCCAGACAAGCCCCGGAGCGCGGCCGAGCACCGCAAGTCCTCCAAGCCGGTCATGGAGAAG
CGGCGCCGAGCGCGTATTAACGAGAGCCTCGCTCAGCTCAAAACCCTCATCCTGGACGCCCTCAGAAAAGAGCAGACCTACTCCAATGAA
GTCCATTGTGTTGAAGAGATTCTGAAGGAAATGACCCATTCATGGCCGCCTCCTTTGACAGCAATACATACGCCTAGTACAGCTGAGCCA
TCCAAGTTTCCTTTCCCTACAAAGGACTCTCAGCATGTCAGTTCTGTAACCCAAAACCAAAAACAATATGATACATCTTCAAAAACTCAC
TCAAATTCTCAGCAAGGAACGTCATCCATGCTCGAAGACGACCTTCAGCTCAGTGACAGTGAGGACAGTGACAGTGAACAAACCCCAGAG
AAGCCTCCCTCCTCATCTGCACCTCCAAGTGCTCCACAGTCCCTTCCAGAACCAGTGGCATCAGCACATTCCAGCAGTGCAGAGTCAGAA
AGCACCAGTGACTCAGACAGTTCCTCAGACTCAGAGAGCGAGAGCAGTTCAAGTGACAGCGAAGAAAATGAGCCCCTAGAAACCCCAGCT
CCGGAGCCTGAGCCTCCAACAACAAACAAATGGCAGCTGGACAACTGGCTGACCAAAGTCAGCCAGCCAGCTGCGCCACCAGAGGGCCCC
AGGAGCACAGAGCCCCCACGGCGGCACCCAGAGAGTAAGGGCAGCAGCGACAGTGCCACGAGTCAGGAGCATTCTGAATCCAAAGATCCT
CCCCCTAAAAGCTCCAGCAAAGCCCCCCGGGCCCCACCCGAAGCCCCCCACCCCGGAAAGAGGAGCTGTCAGAAGTCTCCGGCACAGCAG
GAGCCCCCACAAAGGCAAACCGTTGGAACCAAACAACCCAAAAAACCTGTCAAGGCCTCTGCCCGGGCAGGTTCACGGACCAGCCTGCAG
GGGGAAAGGGAGCCAGGGCTTCTTCCCTATGGCTCCCGAGACCAGACTTCCAAAGACAAGCCCAAGGTGAAGACGAAAGGACGGCCCCGG
GCCGCAGCAAGCAACGAACCCAAGCCAGCAGTGCCCCCCTCCAGTGAGAAGAAGAAGCACAAGAGCTCCCTCCCTGCCCCCTCTAAGGCT
CTCTCAGGCCCAGAACCCGCGAAGGACAATGTGGAGGACAGGACCCCTGAGCACTTTGCTCTTGTTCCCCTGACTGAGAGCCAGGGCCCA
CCCCACAGTGGCAGCGGCAGCAGGACTAGTGGCTGCCGCCAAGCCGTGGTGGTCCAGGAGGACAGCCGCAAAGACAGACTCCCATTGCCT
TTGAGAGACACCAAGCTGCTCTCACCGCTCAGGGACACTCCTCCCCCACAAAGCTTGATGGTGAAGATCACCCTAGACCTGCTCTCTCGG
ATACCCCAGCCTCCCGGGAAGGGGAGCCGCCAGAGGAAAGCAGAAGATAAACAGCCGCCCGCAGGGAAGAAGCACAGCTCTGAGAAGAGG
AGCTCAGACAGCTCAAGCAAGTTGGCCAAAAAGAGAAAGGGTGAAGCAGAAAGAGACTGTGATAACAAGAAAATCAGACTGGAGAAGGAA
ATCAAATCACAGTCATCTTCATCTTCATCCTCCCACAAAGAATCTTCTAAAACAAAGCCCTCCAGGCCCTCCTCACAGTCCTCAAAGAAG
GAAATGCTCCCCCCGCCACCCGTGTCCTCGTCCTCCCAGAAGCCAGCCAAGCCTGCACTTAAGAGGTCAAGGCGGGAAGCAGACACCTGT
GGCCAGGACCCTCCCAAAAGTGCCAGCAGTACCAAGAGCAACCACAAAGACTCTTCCATTCCCAAGCAGAGAAGAGTAGAGGGGAAGGGC
TCCAGAAGCTCCTCGGAGCACAAGGGTTCTTCCGGAGATACTGCAAATCCTTTTCCAGTGCCTTCTTTGCCAAATGGTAACTCTAAACCA
GGGAAGCCTCAAGTGAAGTTTGACAAACAACAAGCAGACCTTCACATGAGGGAGGCAAAAAAGATGAAGCAGAAAGCAGAGTTAATGACG
GACAGGGTTGGAAAGGCTTTTAAGTACCTGGAAGCCGTCTTGTCCTTCATTGAGTGCGGAATTGCCACAGAGTCTGAAAGCCAGTCATCC
AAGTCAGCTTACTCTGTCTACTCAGAAACTGTAGATCTCATTAAATTCATAATGTCATTAAAATCCTTCTCAGATGCCACAGCGCCAACA
CAAGAGAAAATATTTGCTGTTTTATGCATGCGTTGCCAGTCCATTTTGAACATGGCGATGTTTCGTTGTAAAAAAGACATAGCAATAAAG
TATTCTCGTACTCTTAATAAACACTTCGAGAGTTCTTCCAAAGTCGCCCAGGCACCTTCTCCATGCATTGCAAGCACAGGCACACCATCC
CCTCTTTCCCCAATGCCTTCTCCTGCCAGCTCCGTAGGGTCCCAGTCAAGTGCTGGCAGTGTGGGGAGCAGTGGGGTGGCTGCCACTATC
AGCACCCCAGTCACCATCCAGAATATGACATCTTCCTATGTCACCATCACATCCCATGTTCTTACCGCCTTTGACCTTTGGGAACAGGCC
GAGGCCCTCACGAGGAAGAATAAAGAATTCTTTGCTCGGCTCAGCACAAATGTGTGCACCTTGGCCCTCAACAGCAGTTTGGTGGACCTG
GTGCACTATACACGACAGGGTTTTCAGCAGCTACAAGAATTAACCAAAACACCTTAATGGAGCCCCAGGTTGATTCAATGCCTTGGGAAC
TATTTTTGCACATTGGAAGCCTCAAAAACAGTCCAGACATTTGTTTCATCAGGACACCAAACTCTAAAAAAGAAGCACCACGAGATGGCC
AGGACATTTGTCCACTTAAACTCTCAACAACAGTGTGATCATTGGTTGGACACTGTGGTTATGCAGAAGCAGAGATGAGGAGGCTGGCCC
CAGAGATGATCTTGCCCTTCCTAACTAAAGGACAGAAGTGCAATTTAGCTTAAATGGGTGTATGAATGGTCTAGAAACATTTCTATTTTT
TTTTTAAACCAGCAGGATACAAGTTGCAAATGAAATGAGGAGAAACAGTTTCAACTCTGAAAGTGAATTTCACGTCATCTCAGTAGCCAC
GCTAGTCCATTCCCAGAAGGAAATTTTTTTTTTTAACAATGACTTTTGGTAAAGGGTTTTGTGGATGATTTTTTTTCTTTTGAGTTTTGG
GAGAAATATTTGTTTAGTAACTTCTAATGGCCATCTGTAAACCATAAGTAATGAAGGACTCCACTGTGCCCCACTTTCTGCCAATGAACA
GTGGCTTGATAATACCAAGTATTGTTGTAATTTATAAAATTGAAGGCAACCCCCGCTCCTGCCGCCCCCAATCTCCCCATTGCCTAGAGC
GCTGCACATTGACCCCAGCTCTGACTTCTCATTACTGTGCTGAAAGTCAGCCCACGTCGGAGCGGTGAGGAGGAGCCACAGCACATGGGG
TGCCACCTCGAGGTCTGCACAGGAGGACTTGGCGCTGCCATTTCCTACCCCTGCCATTTCCCACCCCTGCTTCAGCGAAAGGGACTCTCT
AACAGGGCAGTCACTGTTGACTCTATTCTGAATTTCCTCCCTTGGGGAAGAAGGGAACCAACATTTATACCTGACCAGATGGCTAAAGTG
CTTTTAAAGTTTTGTTTAAGTAGAGCTGGAATTTGAGGTGCTGATCTGTGGTCTACAGTTATGTGGTAACTCATGTTGTCCAGCCAACTC
AGAGTTTCGTCAGTGAACAAGAAACATGAAATCTGCTTCTTAGAGAGGCTATATTTTTCTGCTACAAATATTTTATATTTATAGCAAAAC
TAGACTTTCAGAGTCCTTGATTGTCTAGGGGAAGTTAACTCCCTGAGAGGATGTAGAGATTTGGGGTGGTTGATTAGACTTTTGAAAAAC
TCATCACCACATGCCTTCACTCCAGAGTGTTCTCAGCTAGATTTGATTTGGTTGAGGAGGAACTGTGGCCCTCCGTAAGTTATTGCCATA
GTGTATGCATTAAACCAAGTCCATTTTGAATGACCTAAAATGAAGTAACACAATCAGAAATCCCATGTGCCCATAAGCACAGATTTTTCT
TTTTCATTGAAACTTTAAAGGTTATTATTGGAAACATTACTTTGAGTGCAGTGTTTTTAAAAGCCAATTCTTTTTTATCCCTTTTAGAAG
TAGAATTTGCACACTTACTACAATTGAGGAGTGTCATCTCTATAACTTTTTCTCCGCCTTTGTCCCATTCTGCCCCTGTACATGTTTCCT
ACCAAGCATGTTTCACATTTTCCTATTAGTGGAGGAGGGAGAACCATATTTATTTATAATGAAGACATCTAAGATCCCTATGATGAATGC
AGGAACTCTCTTGGTAGTTTGTAAATACACAAAGGGATGTGTCGAGGGATGGGAGCGATGCTTATCTCTCACAGTGTGAGTGGTCTGTGT
GAGGCTGTTCCTTCAGTTTCTTCTCCAGACTGTTCTTTGGTTGTCACTAAGTCAGAGGTCTGGTCCCTCATGTTTAGGTGAAAGCCAGAG
AATGACAGCTGTAGTCATATCTGAGCATAAGACCTTGATGTGTGATTCCTGATGACCGGTTTCATTTATTCATGTTATAAAGCAAAGCCC
TGGTCCTTTTTAAACTACTAGTTTTAAAAACCTGTGTTAAATGAACAGTAATTGCCTGGTAGGTTTGGTGTGTGTGTAGCATTGTGTGTC
CATCTGTTATATGTAAAGGACAAGGCACCAGAATCAGGCTTTATTTCGATATTGAAGATGTTATTTAACATCTTTCTTTTTTCCTTACTC
CCTTAGCCATCCCCTCCCCTTTTGTCCTATCATTCCCTAGAACAAGCCACCTGTCAATTGTGAAGGGTTGTGTTCTTTATGGCAGGTTCT
ATGCAGATTGTGCCAGAGCATGTGCGTGTTCTGTTGGCAAGCCACAGTGCTCCCTTGACTGAAGACATTTCCAGGTAGATTTCTCAGCCA
GCTCTAAAACAGATTGCTTTTTCAGTGGCCTTACTCTTTGTGGGTTTTTTTTTTTTTCTCTGAACTTGATATAAAGATTTTATTTGTCCC
TTGAAAAAGTAACAAATGTGCATAGATCAATTTGTACTACTTTGGTCATTGGATATTTCTGATCCTTATTGCATTGTACCTAAAGGAGAG
TAACTAATGGTAACCTTTTTAATAGAGTATGTGAAAGGTAGTGGCTGATGAATCCTTAACGTTCATAGGGTCTTTTTGCTGTTACGGTTG
TATATAGAGGTCTGAAGGATTTTTAAAATGATTTGCACTTTTTCACTGCATGCTTACAATTCCCAAAGGCAAAATCTGTACTGAGGTAGA
TCATTTGAAAGGGCTAGATTATAAAATTAAGCCTTAGAGTATGGAAAGTTCTTATAACAATAATAGTACACACTTCAGAGTAAGACAAAT
GCAAAGCATCTTAAGGAGTGAAAATAGAGTGTAAATCTTGCCTTTGGCACTACAAGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCT
TTAGTAGGAAATGGAAGAACACTGTTTTATTTTTTAAAGTGTTTAATGTTTCTGTCCTTTCTGTGAATTATTGAATTTAAGAGCCCTGCT
AAATAATGAAAAAACACTTTACTAAAATTTATCAAATTATACTGGGTTCGGATTGTGAAAACATTGGCCACCTAGTAGCAGTGGTGAGGA
GTGGGAGGGCCCAGCAAGCATTTATCAGAAATAGAATCACAATAGGAGGAGAATTTGACTGTCTGATATTATGATTTGATTACAATACTG
AATGGGAAAAGTATCTAATATTTTGTAACAAAAAGACCTTCATATTATCTGTTTTGACCAAAATATGTAGCTATTTCCCTTACACAGATT
GGACCGCACTTATCTCCCTTGTCCTGTATCCTTTAATTTCAGGTCTCAGGATGTTTAGAAAGCTAAAACCCCCTACCCCTTTCTGGCTGA
AAACTTGCCTTATTTGGTATCTTACACATTAATGTTACTAGCATCAGGAGCTTACTGTTTTATTATGATTCATCTTCAGTAATTTTTAGA
AGCAAGAAGAAAGCCATTGTGTCCTCTACAATTAACAAAACTTATCTCTGATATACAAAGGGATATAAATATATACACTTAAATAGAGAA
AAAGAGGTTGATTGAATTGTGCCTTTGAGTGAACCCAGTTTTTAAATACCGCTGTGTTTGTTTCGCCATGGCTTCAGGGATGCTACATGG
CTCTTGCACCTTTTACTCCTCTGCTTTATGAAGTTTGAGTTGTATTTGTGCATCTTAAAGTAGGTTGAGGCTTGAGGCTGGGCTTTCGGG
TTTTTTTGTTTTTTGTTTTGTTTTGTTTTGTTTTGTTTTCTTGTACTTAAACCTGCTTGCTTCCTACCACAGATTCTTTATTTTCCCAAA
CACTACAAAAAAACTTTTAAAACTTTGCCATTTCATCTGTTTACACTCTTTGCCACTGATTAGCAGTATTTAAATCTTGCAAGAATATTT
TGTGCTTTCTTTAGAAACACAAGAGTATAGATTTTTCTCACTGAAAAGTGAGAGTTACGCATTGCAGCCATGAAGGGATGCTAGGATCAA
TTATGGCAGTACCTTTTTTCCCCTCCTGTTCTTGAGCCAGTTGTCTCTTTTGTTTTGGGTCCCACTTAGGATTAATGGATGTAAGGTATT
TTCCTGTGCCTTTATTTTGTGTCATTCTATTGGAAGGAGGTGTAACGGCAGAATAGCATCGTGTTGGGGGTTTTCCTTCAAACACTGCAA
GTGATATTGCCACCATGTGAACCTCAAATATGCAATCCAGTTGTGTTGGTTTCTCGGTGACTTGGAGTGTTCATCTCTTCATGAATTGTG
AGCACTGACCATGTTCTTCAGTTCTTAATTATGGTGAGTTGACAAATACCAACTACTGCTTTTCTTTAGGTGGCTATAAATTTCTTACTG
TCAGGAGGAAATGACATTATATTCTGTTCCACTGAACGTCAGAGATCAGCAGGCACTGTACTGGGTAGAGAAGTGCCTATACTTCTCTAC
CTAAGAGGGCAGGAGGGAAACCCTACAGCTCCTTGTGAGCCTATATATTAGTATATCGGCCTGGAGAGGACAAGGGAATAAGACCACTCA
TAGTGAGGCTGGCCAAGCTGCACTGGTCGGACCAGGCAGTGGCTGACCTAAGGAAGACAACTTGCTTTGCTTAAAAGTAGATTTTTTAAG
CAATGCTTAACACAGGCAGCATTCACCTTTGTTCAGGCCATCGACATGTATTGTTAAAATTACTGCATATCCCCCTCAGATATCAAGTAT
ACACTGTTCATGTTGGGGTTGTGTGTGTGTATGTGTGTATGTACGCACGCATGTGTCCCAAATCTTGTTTTAATTTTTTTTTTCTGAATG
TGATCATGTTTTGGATGATACCTGAGCAGGGTTGCCTTTTTTTTATTTATTACCATTATATATTATATTATATTATATTATATATTTTTT
GCTTTCTTATAACTTTGGAGGAAAGTCAAATCTTGGTATTATTAAAATTGTTTTAAAAAGGAGTAAATTTTCCAGTTGATAAATGAAAAT
CACTGGCCTATGTTTAATAAGTTTTTCTTTAATTACTGTGGAATAACGTGCCAGCTATCATCAACACAATGATTTTGTACATAGGGTAGG
GAAGCAGTGATGCTCTCAATGGGAAGATGTGCAACACAAATTAAGGGGAACTCCATGTATTTTACCTACTTCAGCAATGGAACTGCAACT
TGGGGCTTTGTGAATAAAATTTAGCTGCCTTGTATAGTCGTTTGAAAGAATATGTGATCTGTGAGAGAATTATAGTTTTTTTTTAGAAGA
AAAATCTGCAAAAGATCTTTCCAAAGACAATGTGCCACAGATCTTTTGTTCTCTGTAATGAGGATTAATTGCTGTTTAAACAAAAATGTA

>36203_36203_1_HES4-AFF1_HES4_chr1_935072_ENST00000304952_AFF1_chr4_88005272_ENST00000307808_length(amino acids)=932AA_BP=68
MAADTPGKPSASPMAGAPASASRTPDKPRSAAEHRKSSKPVMEKRRRARINESLAQLKTLILDALRKEQTYSNEVHCVEEILKEMTHSWP
PPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLP
EPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRRHPESKGSS
DSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQT
SKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHSGSGSRTSGCRQAV
VVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGEA
ERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCGQDPPKSASSTKSNHK
DSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSF
IECGIATESESQSSKSAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKYSRTLNKHFESSSKVA
QAPSPCIASTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLST

--------------------------------------------------------------
>36203_36203_2_HES4-AFF1_HES4_chr1_935072_ENST00000304952_AFF1_chr4_88005272_ENST00000395146_length(transcript)=8293nt_BP=342nt
GGCCTGAGGCGCGCGCGGGCCTGGAGCCGGGATCCGCCCTAGGGGCTCGGATCGCCGCGCGCTCGCCGCTCGCCCGCCAGCCCGCCCGTG
GTCCGTGGCGGCGCGCTCCACCCGGCACGGGGAGGCGCGGGGCGCACCATGGCCGCAGACACGCCGGGGAAACCGAGCGCCTCGCCGATG
GCAGGAGCGCCGGCCAGCGCCAGCCGGACCCCAGACAAGCCCCGGAGCGCGGCCGAGCACCGCAAGTCCTCCAAGCCGGTCATGGAGAAG
CGGCGCCGAGCGCGTATTAACGAGAGCCTCGCTCAGCTCAAAACCCTCATCCTGGACGCCCTCAGAAAAGAGCAGACCTACTCCAATGAA
GTCCATTGTGTTGAAGAGATTCTGAAGGAAATGACCCATTCATGGCCGCCTCCTTTGACAGCAATACATACGCCTAGTACAGCTGAGCCA
TCCAAGTTTCCTTTCCCTACAAAGGACTCTCAGCATGTCAGTTCTGTAACCCAAAACCAAAAACAATATGATACATCTTCAAAAACTCAC
TCAAATTCTCAGCAAGGAACGTCATCCATGCTCGAAGACGACCTTCAGCTCAGTGACAGTGAGGACAGTGACAGTGAACAAACCCCAGAG
AAGCCTCCCTCCTCATCTGCACCTCCAAGTGCTCCACAGTCCCTTCCAGAACCAGTGGCATCAGCACATTCCAGCAGTGCAGAGTCAGAA
AGCACCAGTGACTCAGACAGTTCCTCAGACTCAGAGAGCGAGAGCAGTTCAAGTGACAGCGAAGAAAATGAGCCCCTAGAAACCCCAGCT
CCGGAGCCTGAGCCTCCAACAACAAACAAATGGCAGCTGGACAACTGGCTGACCAAAGTCAGCCAGCCAGCTGCGCCACCAGAGGGCCCC
AGGAGCACAGAGCCCCCACGGCGGCACCCAGAGAGTAAGGGCAGCAGCGACAGTGCCACGAGTCAGGAGCATTCTGAATCCAAAGATCCT
CCCCCTAAAAGCTCCAGCAAAGCCCCCCGGGCCCCACCCGAAGCCCCCCACCCCGGAAAGAGGAGCTGTCAGAAGTCTCCGGCACAGCAG
GAGCCCCCACAAAGGCAAACCGTTGGAACCAAACAACCCAAAAAACCTGTCAAGGCCTCTGCCCGGGCAGGTTCACGGACCAGCCTGCAG
GGGGAAAGGGAGCCAGGGCTTCTTCCCTATGGCTCCCGAGACCAGACTTCCAAAGACAAGCCCAAGGTGAAGACGAAAGGACGGCCCCGG
GCCGCAGCAAGCAACGAACCCAAGCCAGCAGTGCCCCCCTCCAGTGAGAAGAAGAAGCACAAGAGCTCCCTCCCTGCCCCCTCTAAGGCT
CTCTCAGGCCCAGAACCCGCGAAGGACAATGTGGAGGACAGGACCCCTGAGCACTTTGCTCTTGTTCCCCTGACTGAGAGCCAGGGCCCA
CCCCACAGTGGCAGCGGCAGCAGGACTAGTGGCTGCCGCCAAGCCGTGGTGGTCCAGGAGGACAGCCGCAAAGACAGACTCCCATTGCCT
TTGAGAGACACCAAGCTGCTCTCACCGCTCAGGGACACTCCTCCCCCACAAAGCTTGATGGTGAAGATCACCCTAGACCTGCTCTCTCGG
ATACCCCAGCCTCCCGGGAAGGGGAGCCGCCAGAGGAAAGCAGAAGATAAACAGCCGCCCGCAGGGAAGAAGCACAGCTCTGAGAAGAGG
AGCTCAGACAGCTCAAGCAAGTTGGCCAAAAAGAGAAAGGGTGAAGCAGAAAGAGACTGTGATAACAAGAAAATCAGACTGGAGAAGGAA
ATCAAATCACAGTCATCTTCATCTTCATCCTCCCACAAAGAATCTTCTAAAACAAAGCCCTCCAGGCCCTCCTCACAGTCCTCAAAGAAG
GAAATGCTCCCCCCGCCACCCGTGTCCTCGTCCTCCCAGAAGCCAGCCAAGCCTGCACTTAAGAGGTCAAGGCGGGAAGCAGACACCTGT
GGCCAGGACCCTCCCAAAAGTGCCAGCAGTACCAAGAGCAACCACAAAGACTCTTCCATTCCCAAGCAGAGAAGAGTAGAGGGGAAGGGC
TCCAGAAGCTCCTCGGAGCACAAGGGTTCTTCCGGAGATACTGCAAATCCTTTTCCAGTGCCTTCTTTGCCAAATGGTAACTCTAAACCA
GGGAAGCCTCAAGTGAAGTTTGACAAACAACAAGCAGACCTTCACATGAGGGAGGCAAAAAAGATGAAGCAGAAAGCAGAGTTAATGACG
GACAGGGTTGGAAAGGCTTTTAAGTACCTGGAAGCCGTCTTGTCCTTCATTGAGTGCGGAATTGCCACAGAGTCTGAAAGCCAGTCATCC
AAGTCAGCTTACTCTGTCTACTCAGAAACTGTAGATCTCATTAAATTCATAATGTCATTAAAATCCTTCTCAGATGCCACAGCGCCAACA
CAAGAGAAAATATTTGCTGTTTTATGCATGCGTTGCCAGTCCATTTTGAACATGGCGATGTTTCGTTGTAAAAAAGACATAGCAATAAAG
TATTCTCGTACTCTTAATAAACACTTCGAGAGTTCTTCCAAAGTCGCCCAGGCACCTTCTCCATGCATTGCAAGAAGCACAGGCACACCA
TCCCCTCTTTCCCCAATGCCTTCTCCTGCCAGCTCCGTAGGGTCCCAGTCAAGTGCTGGCAGTGTGGGGAGCAGTGGGGTGGCTGCCACT
ATCAGCACCCCAGTCACCATCCAGAATATGACATCTTCCTATGTCACCATCACATCCCATGTTCTTACCGCCTTTGACCTTTGGGAACAG
GCCGAGGCCCTCACGAGGAAGAATAAAGAATTCTTTGCTCGGCTCAGCACAAATGTGTGCACCTTGGCCCTCAACAGCAGTTTGGTGGAC
CTGGTGCACTATACACGACAGGGTTTTCAGCAGCTACAAGAATTAACCAAAACACCTTAATGGAGCCCCAGGTTGATTCAATGCCTTGGG
AACTATTTTTGCACATTGGAAGCCTCAAAAACAGTCCAGACATTTGTTTCATCAGGACACCAAACTCTAAAAAAGAAGCACCACGAGATG
GCCAGGACATTTGTCCACTTAAACTCTCAACAACAGTGTGATCATTGGTTGGACACTGTGGTTATGCAGAAGCAGAGATGAGGAGGCTGG
CCCCAGAGATGATCTTGCCCTTCCTAACTAAAGGACAGAAGTGCAATTTAGCTTAAATGGGTGTATGAATGGTCTAGAAACATTTCTATT
TTTTTTTTAAACCAGCAGGATACAAGTTGCAAATGAAATGAGGAGAAACAGTTTCAACTCTGAAAGTGAATTTCACGTCATCTCAGTAGC
CACGCTAGTCCATTCCCAGAAGGAAATTTTTTTTTTTAACAATGACTTTTGGTAAAGGGTTTTGTGGATGATTTTTTTTCTTTTGAGTTT
TGGGAGAAATATTTGTTTAGTAACTTCTAATGGCCATCTGTAAACCATAAGTAATGAAGGACTCCACTGTGCCCCACTTTCTGCCAATGA
ACAGTGGCTTGATAATACCAAGTATTGTTGTAATTTATAAAATTGAAGGCAACCCCCGCTCCTGCCGCCCCCAATCTCCCCATTGCCTAG
AGCGCTGCACATTGACCCCAGCTCTGACTTCTCATTACTGTGCTGAAAGTCAGCCCACGTCGGAGCGGTGAGGAGGAGCCACAGCACATG
GGGTGCCACCTCGAGGTCTGCACAGGAGGACTTGGCGCTGCCATTTCCTACCCCTGCCATTTCCCACCCCTGCTTCAGCGAAAGGGACTC
TCTAACAGGGCAGTCACTGTTGACTCTATTCTGAATTTCCTCCCTTGGGGAAGAAGGGAACCAACATTTATACCTGACCAGATGGCTAAA
GTGCTTTTAAAGTTTTGTTTAAGTAGAGCTGGAATTTGAGGTGCTGATCTGTGGTCTACAGTTATGTGGTAACTCATGTTGTCCAGCCAA
CTCAGAGTTTCGTCAGTGAACAAGAAACATGAAATCTGCTTCTTAGAGAGGCTATATTTTTCTGCTACAAATATTTTATATTTATAGCAA
AACTAGACTTTCAGAGTCCTTGATTGTCTAGGGGAAGTTAACTCCCTGAGAGGATGTAGAGATTTGGGGTGGTTGATTAGACTTTTGAAA
AACTCATCACCACATGCCTTCACTCCAGAGTGTTCTCAGCTAGATTTGATTTGGTTGAGGAGGAACTGTGGCCCTCCGTAAGTTATTGCC
ATAGTGTATGCATTAAACCAAGTCCATTTTGAATGACCTAAAATGAAGTAACACAATCAGAAATCCCATGTGCCCATAAGCACAGATTTT
TCTTTTTCATTGAAACTTTAAAGGTTATTATTGGAAACATTACTTTGAGTGCAGTGTTTTTAAAAGCCAATTCTTTTTTATCCCTTTTAG
AAGTAGAATTTGCACACTTACTACAATTGAGGAGTGTCATCTCTATAACTTTTTCTCCGCCTTTGTCCCATTCTGCCCCTGTACATGTTT
CCTACCAAGCATGTTTCACATTTTCCTATTAGTGGAGGAGGGAGAACCATATTTATTTATAATGAAGACATCTAAGATCCCTATGATGAA
TGCAGGAACTCTCTTGGTAGTTTGTAAATACACAAAGGGATGTGTCGAGGGATGGGAGCGATGCTTATCTCTCACAGTGTGAGTGGTCTG
TGTGAGGCTGTTCCTTCAGTTTCTTCTCCAGACTGTTCTTTGGTTGTCACTAAGTCAGAGGTCTGGTCCCTCATGTTTAGGTGAAAGCCA
GAGAATGACAGCTGTAGTCATATCTGAGCATAAGACCTTGATGTGTGATTCCTGATGACCGGTTTCATTTATTCATGTTATAAAGCAAAG
CCCTGGTCCTTTTTAAACTACTAGTTTTAAAAACCTGTGTTAAATGAACAGTAATTGCCTGGTAGGTTTGGTGTGTGTGTAGCATTGTGT
GTCCATCTGTTATATGTAAAGGACAAGGCACCAGAATCAGGCTTTATTTCGATATTGAAGATGTTATTTAACATCTTTCTTTTTTCCTTA
CTCCCTTAGCCATCCCCTCCCCTTTTGTCCTATCATTCCCTAGAACAAGCCACCTGTCAATTGTGAAGGGTTGTGTTCTTTATGGCAGGT
TCTATGCAGATTGTGCCAGAGCATGTGCGTGTTCTGTTGGCAAGCCACAGTGCTCCCTTGACTGAAGACATTTCCAGGTAGATTTCTCAG
CCAGCTCTAAAACAGATTGCTTTTTCAGTGGCCTTACTCTTTGTGGGTTTTTTTTTTTTTCTCTGAACTTGATATAAAGATTTTATTTGT
CCCTTGAAAAAGTAACAAATGTGCATAGATCAATTTGTACTACTTTGGTCATTGGATATTTCTGATCCTTATTGCATTGTACCTAAAGGA
GAGTAACTAATGGTAACCTTTTTAATAGAGTATGTGAAAGGTAGTGGCTGATGAATCCTTAACGTTCATAGGGTCTTTTTGCTGTTACGG
TTGTATATAGAGGTCTGAAGGATTTTTAAAATGATTTGCACTTTTTCACTGCATGCTTACAATTCCCAAAGGCAAAATCTGTACTGAGGT
AGATCATTTGAAAGGGCTAGATTATAAAATTAAGCCTTAGAGTATGGAAAGTTCTTATAACAATAATAGTACACACTTCAGAGTAAGACA
AATGCAAAGCATCTTAAGGAGTGAAAATAGAGTGTAAATCTTGCCTTTGGCACTACAAGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG
TCTTTAGTAGGAAATGGAAGAACACTGTTTTATTTTTTAAAGTGTTTAATGTTTCTGTCCTTTCTGTGAATTATTGAATTTAAGAGCCCT
GCTAAATAATGAAAAAACACTTTACTAAAATTTATCAAATTATACTGGGTTCGGATTGTGAAAACATTGGCCACCTAGTAGCAGTGGTGA
GGAGTGGGAGGGCCCAGCAAGCATTTATCAGAAATAGAATCACAATAGGAGGAGAATTTGACTGTCTGATATTATGATTTGATTACAATA
CTGAATGGGAAAAGTATCTAATATTTTGTAACAAAAAGACCTTCATATTATCTGTTTTGACCAAAATATGTAGCTATTTCCCTTACACAG
ATTGGACCGCACTTATCTCCCTTGTCCTGTATCCTTTAATTTCAGGTCTCAGGATGTTTAGAAAGCTAAAACCCCCTACCCCTTTCTGGC
TGAAAACTTGCCTTATTTGGTATCTTACACATTAATGTTACTAGCATCAGGAGCTTACTGTTTTATTATGATTCATCTTCAGTAATTTTT
AGAAGCAAGAAGAAAGCCATTGTGTCCTCTACAATTAACAAAACTTATCTCTGATATACAAAGGGATATAAATATATACACTTAAATAGA
GAAAAAGAGGTTGATTGAATTGTGCCTTTGAGTGAACCCAGTTTTTAAATACCGCTGTGTTTGTTTCGCCATGGCTTCAGGGATGCTACA
TGGCTCTTGCACCTTTTACTCCTCTGCTTTATGAAGTTTGAGTTGTATTTGTGCATCTTAAAGTAGGTTGAGGCTTGAGGCTGGGCTTTC
GGGTTTTTTTGTTTTTTGTTTTGTTTTGTTTTGTTTTGTTTTCTTGTACTTAAACCTGCTTGCTTCCTACCACAGATTCTTTATTTTCCC
AAACACTACAAAAAAACTTTTAAAACTTTGCCATTTCATCTGTTTACACTCTTTGCCACTGATTAGCAGTATTTAAATCTTGCAAGAATA
TTTTGTGCTTTCTTTAGAAACACAAGAGTATAGATTTTTCTCACTGAAAAGTGAGAGTTACGCATTGCAGCCATGAAGGGATGCTAGGAT
CAATTATGGCAGTACCTTTTTTCCCCTCCTGTTCTTGAGCCAGTTGTCTCTTTTGTTTTGGGTCCCACTTAGGATTAATGGATGTAAGGT
ATTTTCCTGTGCCTTTATTTTGTGTCATTCTATTGGAAGGAGGTGTAACGGCAGAATAGCATCGTGTTGGGGGTTTTCCTTCAAACACTG
CAAGTGATATTGCCACCATGTGAACCTCAAATATGCAATCCAGTTGTGTTGGTTTCTCGGTGACTTGGAGTGTTCATCTCTTCATGAATT
GTGAGCACTGACCATGTTCTTCAGTTCTTAATTATGGTGAGTTGACAAATACCAACTACTGCTTTTCTTTAGGTGGCTATAAATTTCTTA
CTGTCAGGAGGAAATGACATTATATTCTGTTCCACTGAACGTCAGAGATCAGCAGGCACTGTACTGGGTAGAGAAGTGCCTATACTTCTC
TACCTAAGAGGGCAGGAGGGAAACCCTACAGCTCCTTGTGAGCCTATATATTAGTATATCGGCCTGGAGAGGACAAGGGAATAAGACCAC
TCATAGTGAGGCTGGCCAAGCTGCACTGGTCGGACCAGGCAGTGGCTGACCTAAGGAAGACAACTTGCTTTGCTTAAAAGTAGATTTTTT
AAGCAATGCTTAACACAGGCAGCATTCACCTTTGTTCAGGCCATCGACATGTATTGTTAAAATTACTGCATATCCCCCTCAGATATCAAG
TATACACTGTTCATGTTGGGGTTGTGTGTGTGTATGTGTGTATGTACGCACGCATGTGTCCCAAATCTTGTTTTAATTTTTTTTTTCTGA
ATGTGATCATGTTTTGGATGATACCTGAGCAGGGTTGCCTTTTTTTTATTTATTACCATTATATATTATATTATATTATATTATATATTT
TTTGCTTTCTTATAACTTTGGAGGAAAGTCAAATCTTGGTATTATTAAAATTGTTTTAAAAAGGAGTAAATTTTCCAGTTGATAAATGAA
AATCACTGGCCTATGTTTAATAAGTTTTTCTTTAATTACTGTGGAATAACGTGCCAGCTATCATCAACACAATGATTTTGTACATAGGGT
AGGGAAGCAGTGATGCTCTCAATGGGAAGATGTGCAACACAAATTAAGGGGAACTCCATGTATTTTACCTACTTCAGCAATGGAACTGCA
ACTTGGGGCTTTGTGAATAAAATTTAGCTGCCTTGTATAGTCGTTTGAAAGAATATGTGATCTGTGAGAGAATTATAGTTTTTTTTTAGA
AGAAAAATCTGCAAAAGATCTTTCCAAAGACAATGTGCCACAGATCTTTTGTTCTCTGTAATGAGGATTAATTGCTGTTTAAACAAAAAT
GTAATTGTTCATCTTTAAATTCTTTCCTTTTCATAAGAGGATCAAGCTGTAAAAAAACAAAAAAATTAATAAAAATTTCGAGAAATCATT

>36203_36203_2_HES4-AFF1_HES4_chr1_935072_ENST00000304952_AFF1_chr4_88005272_ENST00000395146_length(amino acids)=933AA_BP=68
MAADTPGKPSASPMAGAPASASRTPDKPRSAAEHRKSSKPVMEKRRRARINESLAQLKTLILDALRKEQTYSNEVHCVEEILKEMTHSWP
PPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLP
EPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRRHPESKGSS
DSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQT
SKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHSGSGSRTSGCRQAV
VVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGEA
ERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCGQDPPKSASSTKSNHK
DSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSF
IECGIATESESQSSKSAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKYSRTLNKHFESSSKVA
QAPSPCIARSTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLS

--------------------------------------------------------------
>36203_36203_3_HES4-AFF1_HES4_chr1_935072_ENST00000428771_AFF1_chr4_88005272_ENST00000307808_length(transcript)=8413nt_BP=481nt
GGGAAAGAATGCGGAGCCGGGTTCACACACCCCGCGGCGGCGAGGCCTTAAATAGGGAAACGGCCTGAGGCGCGCGCGGGCCTGGAGCCG
GGATCCGCCCTAGGGGCTCGGATCGCCGCGCGCTCGCCGCTCGCCCGCCAGCCCGCCCGTGGTCCGTGGCGGCGCGCTCCACCCGGCACG
GGGAGGCGCGGGGCGCACCATGGCCGCAGACACGCCGGGGAAACCGAGCGCCTCGCCGATGGCAGGAGCGCCGGCCAGCGCCAGCCGGAC
CCCAGACAAGCCCCGGAGCGCGGCCGAGCACCGCAAGGTGGGGTCCCGGCCGGGCGTGAGGGGGGCGACCGGGGGGCGGGAGGGACGCGG
GACTCAGCCGGTGCCCGACCCGCAGTCCTCCAAGCCGGTCATGGAGAAGCGGCGCCGAGCGCGTATTAACGAGAGCCTCGCTCAGCTCAA
AACCCTCATCCTGGACGCCCTCAGAAAAGAGCAGACCTACTCCAATGAAGTCCATTGTGTTGAAGAGATTCTGAAGGAAATGACCCATTC
ATGGCCGCCTCCTTTGACAGCAATACATACGCCTAGTACAGCTGAGCCATCCAAGTTTCCTTTCCCTACAAAGGACTCTCAGCATGTCAG
TTCTGTAACCCAAAACCAAAAACAATATGATACATCTTCAAAAACTCACTCAAATTCTCAGCAAGGAACGTCATCCATGCTCGAAGACGA
CCTTCAGCTCAGTGACAGTGAGGACAGTGACAGTGAACAAACCCCAGAGAAGCCTCCCTCCTCATCTGCACCTCCAAGTGCTCCACAGTC
CCTTCCAGAACCAGTGGCATCAGCACATTCCAGCAGTGCAGAGTCAGAAAGCACCAGTGACTCAGACAGTTCCTCAGACTCAGAGAGCGA
GAGCAGTTCAAGTGACAGCGAAGAAAATGAGCCCCTAGAAACCCCAGCTCCGGAGCCTGAGCCTCCAACAACAAACAAATGGCAGCTGGA
CAACTGGCTGACCAAAGTCAGCCAGCCAGCTGCGCCACCAGAGGGCCCCAGGAGCACAGAGCCCCCACGGCGGCACCCAGAGAGTAAGGG
CAGCAGCGACAGTGCCACGAGTCAGGAGCATTCTGAATCCAAAGATCCTCCCCCTAAAAGCTCCAGCAAAGCCCCCCGGGCCCCACCCGA
AGCCCCCCACCCCGGAAAGAGGAGCTGTCAGAAGTCTCCGGCACAGCAGGAGCCCCCACAAAGGCAAACCGTTGGAACCAAACAACCCAA
AAAACCTGTCAAGGCCTCTGCCCGGGCAGGTTCACGGACCAGCCTGCAGGGGGAAAGGGAGCCAGGGCTTCTTCCCTATGGCTCCCGAGA
CCAGACTTCCAAAGACAAGCCCAAGGTGAAGACGAAAGGACGGCCCCGGGCCGCAGCAAGCAACGAACCCAAGCCAGCAGTGCCCCCCTC
CAGTGAGAAGAAGAAGCACAAGAGCTCCCTCCCTGCCCCCTCTAAGGCTCTCTCAGGCCCAGAACCCGCGAAGGACAATGTGGAGGACAG
GACCCCTGAGCACTTTGCTCTTGTTCCCCTGACTGAGAGCCAGGGCCCACCCCACAGTGGCAGCGGCAGCAGGACTAGTGGCTGCCGCCA
AGCCGTGGTGGTCCAGGAGGACAGCCGCAAAGACAGACTCCCATTGCCTTTGAGAGACACCAAGCTGCTCTCACCGCTCAGGGACACTCC
TCCCCCACAAAGCTTGATGGTGAAGATCACCCTAGACCTGCTCTCTCGGATACCCCAGCCTCCCGGGAAGGGGAGCCGCCAGAGGAAAGC
AGAAGATAAACAGCCGCCCGCAGGGAAGAAGCACAGCTCTGAGAAGAGGAGCTCAGACAGCTCAAGCAAGTTGGCCAAAAAGAGAAAGGG
TGAAGCAGAAAGAGACTGTGATAACAAGAAAATCAGACTGGAGAAGGAAATCAAATCACAGTCATCTTCATCTTCATCCTCCCACAAAGA
ATCTTCTAAAACAAAGCCCTCCAGGCCCTCCTCACAGTCCTCAAAGAAGGAAATGCTCCCCCCGCCACCCGTGTCCTCGTCCTCCCAGAA
GCCAGCCAAGCCTGCACTTAAGAGGTCAAGGCGGGAAGCAGACACCTGTGGCCAGGACCCTCCCAAAAGTGCCAGCAGTACCAAGAGCAA
CCACAAAGACTCTTCCATTCCCAAGCAGAGAAGAGTAGAGGGGAAGGGCTCCAGAAGCTCCTCGGAGCACAAGGGTTCTTCCGGAGATAC
TGCAAATCCTTTTCCAGTGCCTTCTTTGCCAAATGGTAACTCTAAACCAGGGAAGCCTCAAGTGAAGTTTGACAAACAACAAGCAGACCT
TCACATGAGGGAGGCAAAAAAGATGAAGCAGAAAGCAGAGTTAATGACGGACAGGGTTGGAAAGGCTTTTAAGTACCTGGAAGCCGTCTT
GTCCTTCATTGAGTGCGGAATTGCCACAGAGTCTGAAAGCCAGTCATCCAAGTCAGCTTACTCTGTCTACTCAGAAACTGTAGATCTCAT
TAAATTCATAATGTCATTAAAATCCTTCTCAGATGCCACAGCGCCAACACAAGAGAAAATATTTGCTGTTTTATGCATGCGTTGCCAGTC
CATTTTGAACATGGCGATGTTTCGTTGTAAAAAAGACATAGCAATAAAGTATTCTCGTACTCTTAATAAACACTTCGAGAGTTCTTCCAA
AGTCGCCCAGGCACCTTCTCCATGCATTGCAAGCACAGGCACACCATCCCCTCTTTCCCCAATGCCTTCTCCTGCCAGCTCCGTAGGGTC
CCAGTCAAGTGCTGGCAGTGTGGGGAGCAGTGGGGTGGCTGCCACTATCAGCACCCCAGTCACCATCCAGAATATGACATCTTCCTATGT
CACCATCACATCCCATGTTCTTACCGCCTTTGACCTTTGGGAACAGGCCGAGGCCCTCACGAGGAAGAATAAAGAATTCTTTGCTCGGCT
CAGCACAAATGTGTGCACCTTGGCCCTCAACAGCAGTTTGGTGGACCTGGTGCACTATACACGACAGGGTTTTCAGCAGCTACAAGAATT
AACCAAAACACCTTAATGGAGCCCCAGGTTGATTCAATGCCTTGGGAACTATTTTTGCACATTGGAAGCCTCAAAAACAGTCCAGACATT
TGTTTCATCAGGACACCAAACTCTAAAAAAGAAGCACCACGAGATGGCCAGGACATTTGTCCACTTAAACTCTCAACAACAGTGTGATCA
TTGGTTGGACACTGTGGTTATGCAGAAGCAGAGATGAGGAGGCTGGCCCCAGAGATGATCTTGCCCTTCCTAACTAAAGGACAGAAGTGC
AATTTAGCTTAAATGGGTGTATGAATGGTCTAGAAACATTTCTATTTTTTTTTTAAACCAGCAGGATACAAGTTGCAAATGAAATGAGGA
GAAACAGTTTCAACTCTGAAAGTGAATTTCACGTCATCTCAGTAGCCACGCTAGTCCATTCCCAGAAGGAAATTTTTTTTTTTAACAATG
ACTTTTGGTAAAGGGTTTTGTGGATGATTTTTTTTCTTTTGAGTTTTGGGAGAAATATTTGTTTAGTAACTTCTAATGGCCATCTGTAAA
CCATAAGTAATGAAGGACTCCACTGTGCCCCACTTTCTGCCAATGAACAGTGGCTTGATAATACCAAGTATTGTTGTAATTTATAAAATT
GAAGGCAACCCCCGCTCCTGCCGCCCCCAATCTCCCCATTGCCTAGAGCGCTGCACATTGACCCCAGCTCTGACTTCTCATTACTGTGCT
GAAAGTCAGCCCACGTCGGAGCGGTGAGGAGGAGCCACAGCACATGGGGTGCCACCTCGAGGTCTGCACAGGAGGACTTGGCGCTGCCAT
TTCCTACCCCTGCCATTTCCCACCCCTGCTTCAGCGAAAGGGACTCTCTAACAGGGCAGTCACTGTTGACTCTATTCTGAATTTCCTCCC
TTGGGGAAGAAGGGAACCAACATTTATACCTGACCAGATGGCTAAAGTGCTTTTAAAGTTTTGTTTAAGTAGAGCTGGAATTTGAGGTGC
TGATCTGTGGTCTACAGTTATGTGGTAACTCATGTTGTCCAGCCAACTCAGAGTTTCGTCAGTGAACAAGAAACATGAAATCTGCTTCTT
AGAGAGGCTATATTTTTCTGCTACAAATATTTTATATTTATAGCAAAACTAGACTTTCAGAGTCCTTGATTGTCTAGGGGAAGTTAACTC
CCTGAGAGGATGTAGAGATTTGGGGTGGTTGATTAGACTTTTGAAAAACTCATCACCACATGCCTTCACTCCAGAGTGTTCTCAGCTAGA
TTTGATTTGGTTGAGGAGGAACTGTGGCCCTCCGTAAGTTATTGCCATAGTGTATGCATTAAACCAAGTCCATTTTGAATGACCTAAAAT
GAAGTAACACAATCAGAAATCCCATGTGCCCATAAGCACAGATTTTTCTTTTTCATTGAAACTTTAAAGGTTATTATTGGAAACATTACT
TTGAGTGCAGTGTTTTTAAAAGCCAATTCTTTTTTATCCCTTTTAGAAGTAGAATTTGCACACTTACTACAATTGAGGAGTGTCATCTCT
ATAACTTTTTCTCCGCCTTTGTCCCATTCTGCCCCTGTACATGTTTCCTACCAAGCATGTTTCACATTTTCCTATTAGTGGAGGAGGGAG
AACCATATTTATTTATAATGAAGACATCTAAGATCCCTATGATGAATGCAGGAACTCTCTTGGTAGTTTGTAAATACACAAAGGGATGTG
TCGAGGGATGGGAGCGATGCTTATCTCTCACAGTGTGAGTGGTCTGTGTGAGGCTGTTCCTTCAGTTTCTTCTCCAGACTGTTCTTTGGT
TGTCACTAAGTCAGAGGTCTGGTCCCTCATGTTTAGGTGAAAGCCAGAGAATGACAGCTGTAGTCATATCTGAGCATAAGACCTTGATGT
GTGATTCCTGATGACCGGTTTCATTTATTCATGTTATAAAGCAAAGCCCTGGTCCTTTTTAAACTACTAGTTTTAAAAACCTGTGTTAAA
TGAACAGTAATTGCCTGGTAGGTTTGGTGTGTGTGTAGCATTGTGTGTCCATCTGTTATATGTAAAGGACAAGGCACCAGAATCAGGCTT
TATTTCGATATTGAAGATGTTATTTAACATCTTTCTTTTTTCCTTACTCCCTTAGCCATCCCCTCCCCTTTTGTCCTATCATTCCCTAGA
ACAAGCCACCTGTCAATTGTGAAGGGTTGTGTTCTTTATGGCAGGTTCTATGCAGATTGTGCCAGAGCATGTGCGTGTTCTGTTGGCAAG
CCACAGTGCTCCCTTGACTGAAGACATTTCCAGGTAGATTTCTCAGCCAGCTCTAAAACAGATTGCTTTTTCAGTGGCCTTACTCTTTGT
GGGTTTTTTTTTTTTTCTCTGAACTTGATATAAAGATTTTATTTGTCCCTTGAAAAAGTAACAAATGTGCATAGATCAATTTGTACTACT
TTGGTCATTGGATATTTCTGATCCTTATTGCATTGTACCTAAAGGAGAGTAACTAATGGTAACCTTTTTAATAGAGTATGTGAAAGGTAG
TGGCTGATGAATCCTTAACGTTCATAGGGTCTTTTTGCTGTTACGGTTGTATATAGAGGTCTGAAGGATTTTTAAAATGATTTGCACTTT
TTCACTGCATGCTTACAATTCCCAAAGGCAAAATCTGTACTGAGGTAGATCATTTGAAAGGGCTAGATTATAAAATTAAGCCTTAGAGTA
TGGAAAGTTCTTATAACAATAATAGTACACACTTCAGAGTAAGACAAATGCAAAGCATCTTAAGGAGTGAAAATAGAGTGTAAATCTTGC
CTTTGGCACTACAAGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTTTAGTAGGAAATGGAAGAACACTGTTTTATTTTTTAAAGTG
TTTAATGTTTCTGTCCTTTCTGTGAATTATTGAATTTAAGAGCCCTGCTAAATAATGAAAAAACACTTTACTAAAATTTATCAAATTATA
CTGGGTTCGGATTGTGAAAACATTGGCCACCTAGTAGCAGTGGTGAGGAGTGGGAGGGCCCAGCAAGCATTTATCAGAAATAGAATCACA
ATAGGAGGAGAATTTGACTGTCTGATATTATGATTTGATTACAATACTGAATGGGAAAAGTATCTAATATTTTGTAACAAAAAGACCTTC
ATATTATCTGTTTTGACCAAAATATGTAGCTATTTCCCTTACACAGATTGGACCGCACTTATCTCCCTTGTCCTGTATCCTTTAATTTCA
GGTCTCAGGATGTTTAGAAAGCTAAAACCCCCTACCCCTTTCTGGCTGAAAACTTGCCTTATTTGGTATCTTACACATTAATGTTACTAG
CATCAGGAGCTTACTGTTTTATTATGATTCATCTTCAGTAATTTTTAGAAGCAAGAAGAAAGCCATTGTGTCCTCTACAATTAACAAAAC
TTATCTCTGATATACAAAGGGATATAAATATATACACTTAAATAGAGAAAAAGAGGTTGATTGAATTGTGCCTTTGAGTGAACCCAGTTT
TTAAATACCGCTGTGTTTGTTTCGCCATGGCTTCAGGGATGCTACATGGCTCTTGCACCTTTTACTCCTCTGCTTTATGAAGTTTGAGTT
GTATTTGTGCATCTTAAAGTAGGTTGAGGCTTGAGGCTGGGCTTTCGGGTTTTTTTGTTTTTTGTTTTGTTTTGTTTTGTTTTGTTTTCT
TGTACTTAAACCTGCTTGCTTCCTACCACAGATTCTTTATTTTCCCAAACACTACAAAAAAACTTTTAAAACTTTGCCATTTCATCTGTT
TACACTCTTTGCCACTGATTAGCAGTATTTAAATCTTGCAAGAATATTTTGTGCTTTCTTTAGAAACACAAGAGTATAGATTTTTCTCAC
TGAAAAGTGAGAGTTACGCATTGCAGCCATGAAGGGATGCTAGGATCAATTATGGCAGTACCTTTTTTCCCCTCCTGTTCTTGAGCCAGT
TGTCTCTTTTGTTTTGGGTCCCACTTAGGATTAATGGATGTAAGGTATTTTCCTGTGCCTTTATTTTGTGTCATTCTATTGGAAGGAGGT
GTAACGGCAGAATAGCATCGTGTTGGGGGTTTTCCTTCAAACACTGCAAGTGATATTGCCACCATGTGAACCTCAAATATGCAATCCAGT
TGTGTTGGTTTCTCGGTGACTTGGAGTGTTCATCTCTTCATGAATTGTGAGCACTGACCATGTTCTTCAGTTCTTAATTATGGTGAGTTG
ACAAATACCAACTACTGCTTTTCTTTAGGTGGCTATAAATTTCTTACTGTCAGGAGGAAATGACATTATATTCTGTTCCACTGAACGTCA
GAGATCAGCAGGCACTGTACTGGGTAGAGAAGTGCCTATACTTCTCTACCTAAGAGGGCAGGAGGGAAACCCTACAGCTCCTTGTGAGCC
TATATATTAGTATATCGGCCTGGAGAGGACAAGGGAATAAGACCACTCATAGTGAGGCTGGCCAAGCTGCACTGGTCGGACCAGGCAGTG
GCTGACCTAAGGAAGACAACTTGCTTTGCTTAAAAGTAGATTTTTTAAGCAATGCTTAACACAGGCAGCATTCACCTTTGTTCAGGCCAT
CGACATGTATTGTTAAAATTACTGCATATCCCCCTCAGATATCAAGTATACACTGTTCATGTTGGGGTTGTGTGTGTGTATGTGTGTATG
TACGCACGCATGTGTCCCAAATCTTGTTTTAATTTTTTTTTTCTGAATGTGATCATGTTTTGGATGATACCTGAGCAGGGTTGCCTTTTT
TTTATTTATTACCATTATATATTATATTATATTATATTATATATTTTTTGCTTTCTTATAACTTTGGAGGAAAGTCAAATCTTGGTATTA
TTAAAATTGTTTTAAAAAGGAGTAAATTTTCCAGTTGATAAATGAAAATCACTGGCCTATGTTTAATAAGTTTTTCTTTAATTACTGTGG
AATAACGTGCCAGCTATCATCAACACAATGATTTTGTACATAGGGTAGGGAAGCAGTGATGCTCTCAATGGGAAGATGTGCAACACAAAT
TAAGGGGAACTCCATGTATTTTACCTACTTCAGCAATGGAACTGCAACTTGGGGCTTTGTGAATAAAATTTAGCTGCCTTGTATAGTCGT
TTGAAAGAATATGTGATCTGTGAGAGAATTATAGTTTTTTTTTAGAAGAAAAATCTGCAAAAGATCTTTCCAAAGACAATGTGCCACAGA
TCTTTTGTTCTCTGTAATGAGGATTAATTGCTGTTTAAACAAAAATGTAATTGTTCATCTTTAAATTCTTTCCTTTTCATAAGAGGATCA

>36203_36203_3_HES4-AFF1_HES4_chr1_935072_ENST00000428771_AFF1_chr4_88005272_ENST00000307808_length(amino acids)=958AA_BP=94
MAADTPGKPSASPMAGAPASASRTPDKPRSAAEHRKVGSRPGVRGATGGREGRGTQPVPDPQSSKPVMEKRRRARINESLAQLKTLILDA
LRKEQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDS
EDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKV
SQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKAS
ARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFA
LVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPP
AGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPAL
KRSRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAK
KMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAM
FRCKKDIAIKYSRTLNKHFESSSKVAQAPSPCIASTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHV

--------------------------------------------------------------
>36203_36203_4_HES4-AFF1_HES4_chr1_935072_ENST00000428771_AFF1_chr4_88005272_ENST00000395146_length(transcript)=8432nt_BP=481nt
GGGAAAGAATGCGGAGCCGGGTTCACACACCCCGCGGCGGCGAGGCCTTAAATAGGGAAACGGCCTGAGGCGCGCGCGGGCCTGGAGCCG
GGATCCGCCCTAGGGGCTCGGATCGCCGCGCGCTCGCCGCTCGCCCGCCAGCCCGCCCGTGGTCCGTGGCGGCGCGCTCCACCCGGCACG
GGGAGGCGCGGGGCGCACCATGGCCGCAGACACGCCGGGGAAACCGAGCGCCTCGCCGATGGCAGGAGCGCCGGCCAGCGCCAGCCGGAC
CCCAGACAAGCCCCGGAGCGCGGCCGAGCACCGCAAGGTGGGGTCCCGGCCGGGCGTGAGGGGGGCGACCGGGGGGCGGGAGGGACGCGG
GACTCAGCCGGTGCCCGACCCGCAGTCCTCCAAGCCGGTCATGGAGAAGCGGCGCCGAGCGCGTATTAACGAGAGCCTCGCTCAGCTCAA
AACCCTCATCCTGGACGCCCTCAGAAAAGAGCAGACCTACTCCAATGAAGTCCATTGTGTTGAAGAGATTCTGAAGGAAATGACCCATTC
ATGGCCGCCTCCTTTGACAGCAATACATACGCCTAGTACAGCTGAGCCATCCAAGTTTCCTTTCCCTACAAAGGACTCTCAGCATGTCAG
TTCTGTAACCCAAAACCAAAAACAATATGATACATCTTCAAAAACTCACTCAAATTCTCAGCAAGGAACGTCATCCATGCTCGAAGACGA
CCTTCAGCTCAGTGACAGTGAGGACAGTGACAGTGAACAAACCCCAGAGAAGCCTCCCTCCTCATCTGCACCTCCAAGTGCTCCACAGTC
CCTTCCAGAACCAGTGGCATCAGCACATTCCAGCAGTGCAGAGTCAGAAAGCACCAGTGACTCAGACAGTTCCTCAGACTCAGAGAGCGA
GAGCAGTTCAAGTGACAGCGAAGAAAATGAGCCCCTAGAAACCCCAGCTCCGGAGCCTGAGCCTCCAACAACAAACAAATGGCAGCTGGA
CAACTGGCTGACCAAAGTCAGCCAGCCAGCTGCGCCACCAGAGGGCCCCAGGAGCACAGAGCCCCCACGGCGGCACCCAGAGAGTAAGGG
CAGCAGCGACAGTGCCACGAGTCAGGAGCATTCTGAATCCAAAGATCCTCCCCCTAAAAGCTCCAGCAAAGCCCCCCGGGCCCCACCCGA
AGCCCCCCACCCCGGAAAGAGGAGCTGTCAGAAGTCTCCGGCACAGCAGGAGCCCCCACAAAGGCAAACCGTTGGAACCAAACAACCCAA
AAAACCTGTCAAGGCCTCTGCCCGGGCAGGTTCACGGACCAGCCTGCAGGGGGAAAGGGAGCCAGGGCTTCTTCCCTATGGCTCCCGAGA
CCAGACTTCCAAAGACAAGCCCAAGGTGAAGACGAAAGGACGGCCCCGGGCCGCAGCAAGCAACGAACCCAAGCCAGCAGTGCCCCCCTC
CAGTGAGAAGAAGAAGCACAAGAGCTCCCTCCCTGCCCCCTCTAAGGCTCTCTCAGGCCCAGAACCCGCGAAGGACAATGTGGAGGACAG
GACCCCTGAGCACTTTGCTCTTGTTCCCCTGACTGAGAGCCAGGGCCCACCCCACAGTGGCAGCGGCAGCAGGACTAGTGGCTGCCGCCA
AGCCGTGGTGGTCCAGGAGGACAGCCGCAAAGACAGACTCCCATTGCCTTTGAGAGACACCAAGCTGCTCTCACCGCTCAGGGACACTCC
TCCCCCACAAAGCTTGATGGTGAAGATCACCCTAGACCTGCTCTCTCGGATACCCCAGCCTCCCGGGAAGGGGAGCCGCCAGAGGAAAGC
AGAAGATAAACAGCCGCCCGCAGGGAAGAAGCACAGCTCTGAGAAGAGGAGCTCAGACAGCTCAAGCAAGTTGGCCAAAAAGAGAAAGGG
TGAAGCAGAAAGAGACTGTGATAACAAGAAAATCAGACTGGAGAAGGAAATCAAATCACAGTCATCTTCATCTTCATCCTCCCACAAAGA
ATCTTCTAAAACAAAGCCCTCCAGGCCCTCCTCACAGTCCTCAAAGAAGGAAATGCTCCCCCCGCCACCCGTGTCCTCGTCCTCCCAGAA
GCCAGCCAAGCCTGCACTTAAGAGGTCAAGGCGGGAAGCAGACACCTGTGGCCAGGACCCTCCCAAAAGTGCCAGCAGTACCAAGAGCAA
CCACAAAGACTCTTCCATTCCCAAGCAGAGAAGAGTAGAGGGGAAGGGCTCCAGAAGCTCCTCGGAGCACAAGGGTTCTTCCGGAGATAC
TGCAAATCCTTTTCCAGTGCCTTCTTTGCCAAATGGTAACTCTAAACCAGGGAAGCCTCAAGTGAAGTTTGACAAACAACAAGCAGACCT
TCACATGAGGGAGGCAAAAAAGATGAAGCAGAAAGCAGAGTTAATGACGGACAGGGTTGGAAAGGCTTTTAAGTACCTGGAAGCCGTCTT
GTCCTTCATTGAGTGCGGAATTGCCACAGAGTCTGAAAGCCAGTCATCCAAGTCAGCTTACTCTGTCTACTCAGAAACTGTAGATCTCAT
TAAATTCATAATGTCATTAAAATCCTTCTCAGATGCCACAGCGCCAACACAAGAGAAAATATTTGCTGTTTTATGCATGCGTTGCCAGTC
CATTTTGAACATGGCGATGTTTCGTTGTAAAAAAGACATAGCAATAAAGTATTCTCGTACTCTTAATAAACACTTCGAGAGTTCTTCCAA
AGTCGCCCAGGCACCTTCTCCATGCATTGCAAGAAGCACAGGCACACCATCCCCTCTTTCCCCAATGCCTTCTCCTGCCAGCTCCGTAGG
GTCCCAGTCAAGTGCTGGCAGTGTGGGGAGCAGTGGGGTGGCTGCCACTATCAGCACCCCAGTCACCATCCAGAATATGACATCTTCCTA
TGTCACCATCACATCCCATGTTCTTACCGCCTTTGACCTTTGGGAACAGGCCGAGGCCCTCACGAGGAAGAATAAAGAATTCTTTGCTCG
GCTCAGCACAAATGTGTGCACCTTGGCCCTCAACAGCAGTTTGGTGGACCTGGTGCACTATACACGACAGGGTTTTCAGCAGCTACAAGA
ATTAACCAAAACACCTTAATGGAGCCCCAGGTTGATTCAATGCCTTGGGAACTATTTTTGCACATTGGAAGCCTCAAAAACAGTCCAGAC
ATTTGTTTCATCAGGACACCAAACTCTAAAAAAGAAGCACCACGAGATGGCCAGGACATTTGTCCACTTAAACTCTCAACAACAGTGTGA
TCATTGGTTGGACACTGTGGTTATGCAGAAGCAGAGATGAGGAGGCTGGCCCCAGAGATGATCTTGCCCTTCCTAACTAAAGGACAGAAG
TGCAATTTAGCTTAAATGGGTGTATGAATGGTCTAGAAACATTTCTATTTTTTTTTTAAACCAGCAGGATACAAGTTGCAAATGAAATGA
GGAGAAACAGTTTCAACTCTGAAAGTGAATTTCACGTCATCTCAGTAGCCACGCTAGTCCATTCCCAGAAGGAAATTTTTTTTTTTAACA
ATGACTTTTGGTAAAGGGTTTTGTGGATGATTTTTTTTCTTTTGAGTTTTGGGAGAAATATTTGTTTAGTAACTTCTAATGGCCATCTGT
AAACCATAAGTAATGAAGGACTCCACTGTGCCCCACTTTCTGCCAATGAACAGTGGCTTGATAATACCAAGTATTGTTGTAATTTATAAA
ATTGAAGGCAACCCCCGCTCCTGCCGCCCCCAATCTCCCCATTGCCTAGAGCGCTGCACATTGACCCCAGCTCTGACTTCTCATTACTGT
GCTGAAAGTCAGCCCACGTCGGAGCGGTGAGGAGGAGCCACAGCACATGGGGTGCCACCTCGAGGTCTGCACAGGAGGACTTGGCGCTGC
CATTTCCTACCCCTGCCATTTCCCACCCCTGCTTCAGCGAAAGGGACTCTCTAACAGGGCAGTCACTGTTGACTCTATTCTGAATTTCCT
CCCTTGGGGAAGAAGGGAACCAACATTTATACCTGACCAGATGGCTAAAGTGCTTTTAAAGTTTTGTTTAAGTAGAGCTGGAATTTGAGG
TGCTGATCTGTGGTCTACAGTTATGTGGTAACTCATGTTGTCCAGCCAACTCAGAGTTTCGTCAGTGAACAAGAAACATGAAATCTGCTT
CTTAGAGAGGCTATATTTTTCTGCTACAAATATTTTATATTTATAGCAAAACTAGACTTTCAGAGTCCTTGATTGTCTAGGGGAAGTTAA
CTCCCTGAGAGGATGTAGAGATTTGGGGTGGTTGATTAGACTTTTGAAAAACTCATCACCACATGCCTTCACTCCAGAGTGTTCTCAGCT
AGATTTGATTTGGTTGAGGAGGAACTGTGGCCCTCCGTAAGTTATTGCCATAGTGTATGCATTAAACCAAGTCCATTTTGAATGACCTAA
AATGAAGTAACACAATCAGAAATCCCATGTGCCCATAAGCACAGATTTTTCTTTTTCATTGAAACTTTAAAGGTTATTATTGGAAACATT
ACTTTGAGTGCAGTGTTTTTAAAAGCCAATTCTTTTTTATCCCTTTTAGAAGTAGAATTTGCACACTTACTACAATTGAGGAGTGTCATC
TCTATAACTTTTTCTCCGCCTTTGTCCCATTCTGCCCCTGTACATGTTTCCTACCAAGCATGTTTCACATTTTCCTATTAGTGGAGGAGG
GAGAACCATATTTATTTATAATGAAGACATCTAAGATCCCTATGATGAATGCAGGAACTCTCTTGGTAGTTTGTAAATACACAAAGGGAT
GTGTCGAGGGATGGGAGCGATGCTTATCTCTCACAGTGTGAGTGGTCTGTGTGAGGCTGTTCCTTCAGTTTCTTCTCCAGACTGTTCTTT
GGTTGTCACTAAGTCAGAGGTCTGGTCCCTCATGTTTAGGTGAAAGCCAGAGAATGACAGCTGTAGTCATATCTGAGCATAAGACCTTGA
TGTGTGATTCCTGATGACCGGTTTCATTTATTCATGTTATAAAGCAAAGCCCTGGTCCTTTTTAAACTACTAGTTTTAAAAACCTGTGTT
AAATGAACAGTAATTGCCTGGTAGGTTTGGTGTGTGTGTAGCATTGTGTGTCCATCTGTTATATGTAAAGGACAAGGCACCAGAATCAGG
CTTTATTTCGATATTGAAGATGTTATTTAACATCTTTCTTTTTTCCTTACTCCCTTAGCCATCCCCTCCCCTTTTGTCCTATCATTCCCT
AGAACAAGCCACCTGTCAATTGTGAAGGGTTGTGTTCTTTATGGCAGGTTCTATGCAGATTGTGCCAGAGCATGTGCGTGTTCTGTTGGC
AAGCCACAGTGCTCCCTTGACTGAAGACATTTCCAGGTAGATTTCTCAGCCAGCTCTAAAACAGATTGCTTTTTCAGTGGCCTTACTCTT
TGTGGGTTTTTTTTTTTTTCTCTGAACTTGATATAAAGATTTTATTTGTCCCTTGAAAAAGTAACAAATGTGCATAGATCAATTTGTACT
ACTTTGGTCATTGGATATTTCTGATCCTTATTGCATTGTACCTAAAGGAGAGTAACTAATGGTAACCTTTTTAATAGAGTATGTGAAAGG
TAGTGGCTGATGAATCCTTAACGTTCATAGGGTCTTTTTGCTGTTACGGTTGTATATAGAGGTCTGAAGGATTTTTAAAATGATTTGCAC
TTTTTCACTGCATGCTTACAATTCCCAAAGGCAAAATCTGTACTGAGGTAGATCATTTGAAAGGGCTAGATTATAAAATTAAGCCTTAGA
GTATGGAAAGTTCTTATAACAATAATAGTACACACTTCAGAGTAAGACAAATGCAAAGCATCTTAAGGAGTGAAAATAGAGTGTAAATCT
TGCCTTTGGCACTACAAGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTTTAGTAGGAAATGGAAGAACACTGTTTTATTTTTTAAA
GTGTTTAATGTTTCTGTCCTTTCTGTGAATTATTGAATTTAAGAGCCCTGCTAAATAATGAAAAAACACTTTACTAAAATTTATCAAATT
ATACTGGGTTCGGATTGTGAAAACATTGGCCACCTAGTAGCAGTGGTGAGGAGTGGGAGGGCCCAGCAAGCATTTATCAGAAATAGAATC
ACAATAGGAGGAGAATTTGACTGTCTGATATTATGATTTGATTACAATACTGAATGGGAAAAGTATCTAATATTTTGTAACAAAAAGACC
TTCATATTATCTGTTTTGACCAAAATATGTAGCTATTTCCCTTACACAGATTGGACCGCACTTATCTCCCTTGTCCTGTATCCTTTAATT
TCAGGTCTCAGGATGTTTAGAAAGCTAAAACCCCCTACCCCTTTCTGGCTGAAAACTTGCCTTATTTGGTATCTTACACATTAATGTTAC
TAGCATCAGGAGCTTACTGTTTTATTATGATTCATCTTCAGTAATTTTTAGAAGCAAGAAGAAAGCCATTGTGTCCTCTACAATTAACAA
AACTTATCTCTGATATACAAAGGGATATAAATATATACACTTAAATAGAGAAAAAGAGGTTGATTGAATTGTGCCTTTGAGTGAACCCAG
TTTTTAAATACCGCTGTGTTTGTTTCGCCATGGCTTCAGGGATGCTACATGGCTCTTGCACCTTTTACTCCTCTGCTTTATGAAGTTTGA
GTTGTATTTGTGCATCTTAAAGTAGGTTGAGGCTTGAGGCTGGGCTTTCGGGTTTTTTTGTTTTTTGTTTTGTTTTGTTTTGTTTTGTTT
TCTTGTACTTAAACCTGCTTGCTTCCTACCACAGATTCTTTATTTTCCCAAACACTACAAAAAAACTTTTAAAACTTTGCCATTTCATCT
GTTTACACTCTTTGCCACTGATTAGCAGTATTTAAATCTTGCAAGAATATTTTGTGCTTTCTTTAGAAACACAAGAGTATAGATTTTTCT
CACTGAAAAGTGAGAGTTACGCATTGCAGCCATGAAGGGATGCTAGGATCAATTATGGCAGTACCTTTTTTCCCCTCCTGTTCTTGAGCC
AGTTGTCTCTTTTGTTTTGGGTCCCACTTAGGATTAATGGATGTAAGGTATTTTCCTGTGCCTTTATTTTGTGTCATTCTATTGGAAGGA
GGTGTAACGGCAGAATAGCATCGTGTTGGGGGTTTTCCTTCAAACACTGCAAGTGATATTGCCACCATGTGAACCTCAAATATGCAATCC
AGTTGTGTTGGTTTCTCGGTGACTTGGAGTGTTCATCTCTTCATGAATTGTGAGCACTGACCATGTTCTTCAGTTCTTAATTATGGTGAG
TTGACAAATACCAACTACTGCTTTTCTTTAGGTGGCTATAAATTTCTTACTGTCAGGAGGAAATGACATTATATTCTGTTCCACTGAACG
TCAGAGATCAGCAGGCACTGTACTGGGTAGAGAAGTGCCTATACTTCTCTACCTAAGAGGGCAGGAGGGAAACCCTACAGCTCCTTGTGA
GCCTATATATTAGTATATCGGCCTGGAGAGGACAAGGGAATAAGACCACTCATAGTGAGGCTGGCCAAGCTGCACTGGTCGGACCAGGCA
GTGGCTGACCTAAGGAAGACAACTTGCTTTGCTTAAAAGTAGATTTTTTAAGCAATGCTTAACACAGGCAGCATTCACCTTTGTTCAGGC
CATCGACATGTATTGTTAAAATTACTGCATATCCCCCTCAGATATCAAGTATACACTGTTCATGTTGGGGTTGTGTGTGTGTATGTGTGT
ATGTACGCACGCATGTGTCCCAAATCTTGTTTTAATTTTTTTTTTCTGAATGTGATCATGTTTTGGATGATACCTGAGCAGGGTTGCCTT
TTTTTTATTTATTACCATTATATATTATATTATATTATATTATATATTTTTTGCTTTCTTATAACTTTGGAGGAAAGTCAAATCTTGGTA
TTATTAAAATTGTTTTAAAAAGGAGTAAATTTTCCAGTTGATAAATGAAAATCACTGGCCTATGTTTAATAAGTTTTTCTTTAATTACTG
TGGAATAACGTGCCAGCTATCATCAACACAATGATTTTGTACATAGGGTAGGGAAGCAGTGATGCTCTCAATGGGAAGATGTGCAACACA
AATTAAGGGGAACTCCATGTATTTTACCTACTTCAGCAATGGAACTGCAACTTGGGGCTTTGTGAATAAAATTTAGCTGCCTTGTATAGT
CGTTTGAAAGAATATGTGATCTGTGAGAGAATTATAGTTTTTTTTTAGAAGAAAAATCTGCAAAAGATCTTTCCAAAGACAATGTGCCAC
AGATCTTTTGTTCTCTGTAATGAGGATTAATTGCTGTTTAAACAAAAATGTAATTGTTCATCTTTAAATTCTTTCCTTTTCATAAGAGGA

>36203_36203_4_HES4-AFF1_HES4_chr1_935072_ENST00000428771_AFF1_chr4_88005272_ENST00000395146_length(amino acids)=959AA_BP=94
MAADTPGKPSASPMAGAPASASRTPDKPRSAAEHRKVGSRPGVRGATGGREGRGTQPVPDPQSSKPVMEKRRRARINESLAQLKTLILDA
LRKEQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDS
EDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKV
SQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKAS
ARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFA
LVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPP
AGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPAL
KRSRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAK
KMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAM
FRCKKDIAIKYSRTLNKHFESSSKVAQAPSPCIARSTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSH

--------------------------------------------------------------
>36203_36203_5_HES4-AFF1_HES4_chr1_935246_ENST00000304952_AFF1_chr4_88005272_ENST00000307808_length(transcript)=8178nt_BP=246nt
GGCCTGAGGCGCGCGCGGGCCTGGAGCCGGGATCCGCCCTAGGGGCTCGGATCGCCGCGCGCTCGCCGCTCGCCCGCCAGCCCGCCCGTG
GTCCGTGGCGGCGCGCTCCACCCGGCACGGGGAGGCGCGGGGCGCACCATGGCCGCAGACACGCCGGGGAAACCGAGCGCCTCGCCGATG
GCAGGAGCGCCGGCCAGCGCCAGCCGGACCCCAGACAAGCCCCGGAGCGCGGCCGAGCACCGCAAGCAGACCTACTCCAATGAAGTCCAT
TGTGTTGAAGAGATTCTGAAGGAAATGACCCATTCATGGCCGCCTCCTTTGACAGCAATACATACGCCTAGTACAGCTGAGCCATCCAAG
TTTCCTTTCCCTACAAAGGACTCTCAGCATGTCAGTTCTGTAACCCAAAACCAAAAACAATATGATACATCTTCAAAAACTCACTCAAAT
TCTCAGCAAGGAACGTCATCCATGCTCGAAGACGACCTTCAGCTCAGTGACAGTGAGGACAGTGACAGTGAACAAACCCCAGAGAAGCCT
CCCTCCTCATCTGCACCTCCAAGTGCTCCACAGTCCCTTCCAGAACCAGTGGCATCAGCACATTCCAGCAGTGCAGAGTCAGAAAGCACC
AGTGACTCAGACAGTTCCTCAGACTCAGAGAGCGAGAGCAGTTCAAGTGACAGCGAAGAAAATGAGCCCCTAGAAACCCCAGCTCCGGAG
CCTGAGCCTCCAACAACAAACAAATGGCAGCTGGACAACTGGCTGACCAAAGTCAGCCAGCCAGCTGCGCCACCAGAGGGCCCCAGGAGC
ACAGAGCCCCCACGGCGGCACCCAGAGAGTAAGGGCAGCAGCGACAGTGCCACGAGTCAGGAGCATTCTGAATCCAAAGATCCTCCCCCT
AAAAGCTCCAGCAAAGCCCCCCGGGCCCCACCCGAAGCCCCCCACCCCGGAAAGAGGAGCTGTCAGAAGTCTCCGGCACAGCAGGAGCCC
CCACAAAGGCAAACCGTTGGAACCAAACAACCCAAAAAACCTGTCAAGGCCTCTGCCCGGGCAGGTTCACGGACCAGCCTGCAGGGGGAA
AGGGAGCCAGGGCTTCTTCCCTATGGCTCCCGAGACCAGACTTCCAAAGACAAGCCCAAGGTGAAGACGAAAGGACGGCCCCGGGCCGCA
GCAAGCAACGAACCCAAGCCAGCAGTGCCCCCCTCCAGTGAGAAGAAGAAGCACAAGAGCTCCCTCCCTGCCCCCTCTAAGGCTCTCTCA
GGCCCAGAACCCGCGAAGGACAATGTGGAGGACAGGACCCCTGAGCACTTTGCTCTTGTTCCCCTGACTGAGAGCCAGGGCCCACCCCAC
AGTGGCAGCGGCAGCAGGACTAGTGGCTGCCGCCAAGCCGTGGTGGTCCAGGAGGACAGCCGCAAAGACAGACTCCCATTGCCTTTGAGA
GACACCAAGCTGCTCTCACCGCTCAGGGACACTCCTCCCCCACAAAGCTTGATGGTGAAGATCACCCTAGACCTGCTCTCTCGGATACCC
CAGCCTCCCGGGAAGGGGAGCCGCCAGAGGAAAGCAGAAGATAAACAGCCGCCCGCAGGGAAGAAGCACAGCTCTGAGAAGAGGAGCTCA
GACAGCTCAAGCAAGTTGGCCAAAAAGAGAAAGGGTGAAGCAGAAAGAGACTGTGATAACAAGAAAATCAGACTGGAGAAGGAAATCAAA
TCACAGTCATCTTCATCTTCATCCTCCCACAAAGAATCTTCTAAAACAAAGCCCTCCAGGCCCTCCTCACAGTCCTCAAAGAAGGAAATG
CTCCCCCCGCCACCCGTGTCCTCGTCCTCCCAGAAGCCAGCCAAGCCTGCACTTAAGAGGTCAAGGCGGGAAGCAGACACCTGTGGCCAG
GACCCTCCCAAAAGTGCCAGCAGTACCAAGAGCAACCACAAAGACTCTTCCATTCCCAAGCAGAGAAGAGTAGAGGGGAAGGGCTCCAGA
AGCTCCTCGGAGCACAAGGGTTCTTCCGGAGATACTGCAAATCCTTTTCCAGTGCCTTCTTTGCCAAATGGTAACTCTAAACCAGGGAAG
CCTCAAGTGAAGTTTGACAAACAACAAGCAGACCTTCACATGAGGGAGGCAAAAAAGATGAAGCAGAAAGCAGAGTTAATGACGGACAGG
GTTGGAAAGGCTTTTAAGTACCTGGAAGCCGTCTTGTCCTTCATTGAGTGCGGAATTGCCACAGAGTCTGAAAGCCAGTCATCCAAGTCA
GCTTACTCTGTCTACTCAGAAACTGTAGATCTCATTAAATTCATAATGTCATTAAAATCCTTCTCAGATGCCACAGCGCCAACACAAGAG
AAAATATTTGCTGTTTTATGCATGCGTTGCCAGTCCATTTTGAACATGGCGATGTTTCGTTGTAAAAAAGACATAGCAATAAAGTATTCT
CGTACTCTTAATAAACACTTCGAGAGTTCTTCCAAAGTCGCCCAGGCACCTTCTCCATGCATTGCAAGCACAGGCACACCATCCCCTCTT
TCCCCAATGCCTTCTCCTGCCAGCTCCGTAGGGTCCCAGTCAAGTGCTGGCAGTGTGGGGAGCAGTGGGGTGGCTGCCACTATCAGCACC
CCAGTCACCATCCAGAATATGACATCTTCCTATGTCACCATCACATCCCATGTTCTTACCGCCTTTGACCTTTGGGAACAGGCCGAGGCC
CTCACGAGGAAGAATAAAGAATTCTTTGCTCGGCTCAGCACAAATGTGTGCACCTTGGCCCTCAACAGCAGTTTGGTGGACCTGGTGCAC
TATACACGACAGGGTTTTCAGCAGCTACAAGAATTAACCAAAACACCTTAATGGAGCCCCAGGTTGATTCAATGCCTTGGGAACTATTTT
TGCACATTGGAAGCCTCAAAAACAGTCCAGACATTTGTTTCATCAGGACACCAAACTCTAAAAAAGAAGCACCACGAGATGGCCAGGACA
TTTGTCCACTTAAACTCTCAACAACAGTGTGATCATTGGTTGGACACTGTGGTTATGCAGAAGCAGAGATGAGGAGGCTGGCCCCAGAGA
TGATCTTGCCCTTCCTAACTAAAGGACAGAAGTGCAATTTAGCTTAAATGGGTGTATGAATGGTCTAGAAACATTTCTATTTTTTTTTTA
AACCAGCAGGATACAAGTTGCAAATGAAATGAGGAGAAACAGTTTCAACTCTGAAAGTGAATTTCACGTCATCTCAGTAGCCACGCTAGT
CCATTCCCAGAAGGAAATTTTTTTTTTTAACAATGACTTTTGGTAAAGGGTTTTGTGGATGATTTTTTTTCTTTTGAGTTTTGGGAGAAA
TATTTGTTTAGTAACTTCTAATGGCCATCTGTAAACCATAAGTAATGAAGGACTCCACTGTGCCCCACTTTCTGCCAATGAACAGTGGCT
TGATAATACCAAGTATTGTTGTAATTTATAAAATTGAAGGCAACCCCCGCTCCTGCCGCCCCCAATCTCCCCATTGCCTAGAGCGCTGCA
CATTGACCCCAGCTCTGACTTCTCATTACTGTGCTGAAAGTCAGCCCACGTCGGAGCGGTGAGGAGGAGCCACAGCACATGGGGTGCCAC
CTCGAGGTCTGCACAGGAGGACTTGGCGCTGCCATTTCCTACCCCTGCCATTTCCCACCCCTGCTTCAGCGAAAGGGACTCTCTAACAGG
GCAGTCACTGTTGACTCTATTCTGAATTTCCTCCCTTGGGGAAGAAGGGAACCAACATTTATACCTGACCAGATGGCTAAAGTGCTTTTA
AAGTTTTGTTTAAGTAGAGCTGGAATTTGAGGTGCTGATCTGTGGTCTACAGTTATGTGGTAACTCATGTTGTCCAGCCAACTCAGAGTT
TCGTCAGTGAACAAGAAACATGAAATCTGCTTCTTAGAGAGGCTATATTTTTCTGCTACAAATATTTTATATTTATAGCAAAACTAGACT
TTCAGAGTCCTTGATTGTCTAGGGGAAGTTAACTCCCTGAGAGGATGTAGAGATTTGGGGTGGTTGATTAGACTTTTGAAAAACTCATCA
CCACATGCCTTCACTCCAGAGTGTTCTCAGCTAGATTTGATTTGGTTGAGGAGGAACTGTGGCCCTCCGTAAGTTATTGCCATAGTGTAT
GCATTAAACCAAGTCCATTTTGAATGACCTAAAATGAAGTAACACAATCAGAAATCCCATGTGCCCATAAGCACAGATTTTTCTTTTTCA
TTGAAACTTTAAAGGTTATTATTGGAAACATTACTTTGAGTGCAGTGTTTTTAAAAGCCAATTCTTTTTTATCCCTTTTAGAAGTAGAAT
TTGCACACTTACTACAATTGAGGAGTGTCATCTCTATAACTTTTTCTCCGCCTTTGTCCCATTCTGCCCCTGTACATGTTTCCTACCAAG
CATGTTTCACATTTTCCTATTAGTGGAGGAGGGAGAACCATATTTATTTATAATGAAGACATCTAAGATCCCTATGATGAATGCAGGAAC
TCTCTTGGTAGTTTGTAAATACACAAAGGGATGTGTCGAGGGATGGGAGCGATGCTTATCTCTCACAGTGTGAGTGGTCTGTGTGAGGCT
GTTCCTTCAGTTTCTTCTCCAGACTGTTCTTTGGTTGTCACTAAGTCAGAGGTCTGGTCCCTCATGTTTAGGTGAAAGCCAGAGAATGAC
AGCTGTAGTCATATCTGAGCATAAGACCTTGATGTGTGATTCCTGATGACCGGTTTCATTTATTCATGTTATAAAGCAAAGCCCTGGTCC
TTTTTAAACTACTAGTTTTAAAAACCTGTGTTAAATGAACAGTAATTGCCTGGTAGGTTTGGTGTGTGTGTAGCATTGTGTGTCCATCTG
TTATATGTAAAGGACAAGGCACCAGAATCAGGCTTTATTTCGATATTGAAGATGTTATTTAACATCTTTCTTTTTTCCTTACTCCCTTAG
CCATCCCCTCCCCTTTTGTCCTATCATTCCCTAGAACAAGCCACCTGTCAATTGTGAAGGGTTGTGTTCTTTATGGCAGGTTCTATGCAG
ATTGTGCCAGAGCATGTGCGTGTTCTGTTGGCAAGCCACAGTGCTCCCTTGACTGAAGACATTTCCAGGTAGATTTCTCAGCCAGCTCTA
AAACAGATTGCTTTTTCAGTGGCCTTACTCTTTGTGGGTTTTTTTTTTTTTCTCTGAACTTGATATAAAGATTTTATTTGTCCCTTGAAA
AAGTAACAAATGTGCATAGATCAATTTGTACTACTTTGGTCATTGGATATTTCTGATCCTTATTGCATTGTACCTAAAGGAGAGTAACTA
ATGGTAACCTTTTTAATAGAGTATGTGAAAGGTAGTGGCTGATGAATCCTTAACGTTCATAGGGTCTTTTTGCTGTTACGGTTGTATATA
GAGGTCTGAAGGATTTTTAAAATGATTTGCACTTTTTCACTGCATGCTTACAATTCCCAAAGGCAAAATCTGTACTGAGGTAGATCATTT
GAAAGGGCTAGATTATAAAATTAAGCCTTAGAGTATGGAAAGTTCTTATAACAATAATAGTACACACTTCAGAGTAAGACAAATGCAAAG
CATCTTAAGGAGTGAAAATAGAGTGTAAATCTTGCCTTTGGCACTACAAGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTTTAGTA
GGAAATGGAAGAACACTGTTTTATTTTTTAAAGTGTTTAATGTTTCTGTCCTTTCTGTGAATTATTGAATTTAAGAGCCCTGCTAAATAA
TGAAAAAACACTTTACTAAAATTTATCAAATTATACTGGGTTCGGATTGTGAAAACATTGGCCACCTAGTAGCAGTGGTGAGGAGTGGGA
GGGCCCAGCAAGCATTTATCAGAAATAGAATCACAATAGGAGGAGAATTTGACTGTCTGATATTATGATTTGATTACAATACTGAATGGG
AAAAGTATCTAATATTTTGTAACAAAAAGACCTTCATATTATCTGTTTTGACCAAAATATGTAGCTATTTCCCTTACACAGATTGGACCG
CACTTATCTCCCTTGTCCTGTATCCTTTAATTTCAGGTCTCAGGATGTTTAGAAAGCTAAAACCCCCTACCCCTTTCTGGCTGAAAACTT
GCCTTATTTGGTATCTTACACATTAATGTTACTAGCATCAGGAGCTTACTGTTTTATTATGATTCATCTTCAGTAATTTTTAGAAGCAAG
AAGAAAGCCATTGTGTCCTCTACAATTAACAAAACTTATCTCTGATATACAAAGGGATATAAATATATACACTTAAATAGAGAAAAAGAG
GTTGATTGAATTGTGCCTTTGAGTGAACCCAGTTTTTAAATACCGCTGTGTTTGTTTCGCCATGGCTTCAGGGATGCTACATGGCTCTTG
CACCTTTTACTCCTCTGCTTTATGAAGTTTGAGTTGTATTTGTGCATCTTAAAGTAGGTTGAGGCTTGAGGCTGGGCTTTCGGGTTTTTT
TGTTTTTTGTTTTGTTTTGTTTTGTTTTGTTTTCTTGTACTTAAACCTGCTTGCTTCCTACCACAGATTCTTTATTTTCCCAAACACTAC
AAAAAAACTTTTAAAACTTTGCCATTTCATCTGTTTACACTCTTTGCCACTGATTAGCAGTATTTAAATCTTGCAAGAATATTTTGTGCT
TTCTTTAGAAACACAAGAGTATAGATTTTTCTCACTGAAAAGTGAGAGTTACGCATTGCAGCCATGAAGGGATGCTAGGATCAATTATGG
CAGTACCTTTTTTCCCCTCCTGTTCTTGAGCCAGTTGTCTCTTTTGTTTTGGGTCCCACTTAGGATTAATGGATGTAAGGTATTTTCCTG
TGCCTTTATTTTGTGTCATTCTATTGGAAGGAGGTGTAACGGCAGAATAGCATCGTGTTGGGGGTTTTCCTTCAAACACTGCAAGTGATA
TTGCCACCATGTGAACCTCAAATATGCAATCCAGTTGTGTTGGTTTCTCGGTGACTTGGAGTGTTCATCTCTTCATGAATTGTGAGCACT
GACCATGTTCTTCAGTTCTTAATTATGGTGAGTTGACAAATACCAACTACTGCTTTTCTTTAGGTGGCTATAAATTTCTTACTGTCAGGA
GGAAATGACATTATATTCTGTTCCACTGAACGTCAGAGATCAGCAGGCACTGTACTGGGTAGAGAAGTGCCTATACTTCTCTACCTAAGA
GGGCAGGAGGGAAACCCTACAGCTCCTTGTGAGCCTATATATTAGTATATCGGCCTGGAGAGGACAAGGGAATAAGACCACTCATAGTGA
GGCTGGCCAAGCTGCACTGGTCGGACCAGGCAGTGGCTGACCTAAGGAAGACAACTTGCTTTGCTTAAAAGTAGATTTTTTAAGCAATGC
TTAACACAGGCAGCATTCACCTTTGTTCAGGCCATCGACATGTATTGTTAAAATTACTGCATATCCCCCTCAGATATCAAGTATACACTG
TTCATGTTGGGGTTGTGTGTGTGTATGTGTGTATGTACGCACGCATGTGTCCCAAATCTTGTTTTAATTTTTTTTTTCTGAATGTGATCA
TGTTTTGGATGATACCTGAGCAGGGTTGCCTTTTTTTTATTTATTACCATTATATATTATATTATATTATATTATATATTTTTTGCTTTC
TTATAACTTTGGAGGAAAGTCAAATCTTGGTATTATTAAAATTGTTTTAAAAAGGAGTAAATTTTCCAGTTGATAAATGAAAATCACTGG
CCTATGTTTAATAAGTTTTTCTTTAATTACTGTGGAATAACGTGCCAGCTATCATCAACACAATGATTTTGTACATAGGGTAGGGAAGCA
GTGATGCTCTCAATGGGAAGATGTGCAACACAAATTAAGGGGAACTCCATGTATTTTACCTACTTCAGCAATGGAACTGCAACTTGGGGC
TTTGTGAATAAAATTTAGCTGCCTTGTATAGTCGTTTGAAAGAATATGTGATCTGTGAGAGAATTATAGTTTTTTTTTAGAAGAAAAATC
TGCAAAAGATCTTTCCAAAGACAATGTGCCACAGATCTTTTGTTCTCTGTAATGAGGATTAATTGCTGTTTAAACAAAAATGTAATTGTT

>36203_36203_5_HES4-AFF1_HES4_chr1_935246_ENST00000304952_AFF1_chr4_88005272_ENST00000307808_length(amino acids)=900AA_BP=31
MAADTPGKPSASPMAGAPASASRTPDKPRSAAEHRKQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQ
NQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSS
DSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHP
GKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKK
KHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQS
LMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKT
KPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPF
PVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYSETVDLIKFIM
SLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKYSRTLNKHFESSSKVAQAPSPCIASTGTPSPLSPMPSPASSVGSQSSA
GSVGSSGVAATISTPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLSTNVCTLALNSSLVDLVHYTRQGFQQLQELTKTP

--------------------------------------------------------------
>36203_36203_6_HES4-AFF1_HES4_chr1_935246_ENST00000304952_AFF1_chr4_88005272_ENST00000395146_length(transcript)=8197nt_BP=246nt
GGCCTGAGGCGCGCGCGGGCCTGGAGCCGGGATCCGCCCTAGGGGCTCGGATCGCCGCGCGCTCGCCGCTCGCCCGCCAGCCCGCCCGTG
GTCCGTGGCGGCGCGCTCCACCCGGCACGGGGAGGCGCGGGGCGCACCATGGCCGCAGACACGCCGGGGAAACCGAGCGCCTCGCCGATG
GCAGGAGCGCCGGCCAGCGCCAGCCGGACCCCAGACAAGCCCCGGAGCGCGGCCGAGCACCGCAAGCAGACCTACTCCAATGAAGTCCAT
TGTGTTGAAGAGATTCTGAAGGAAATGACCCATTCATGGCCGCCTCCTTTGACAGCAATACATACGCCTAGTACAGCTGAGCCATCCAAG
TTTCCTTTCCCTACAAAGGACTCTCAGCATGTCAGTTCTGTAACCCAAAACCAAAAACAATATGATACATCTTCAAAAACTCACTCAAAT
TCTCAGCAAGGAACGTCATCCATGCTCGAAGACGACCTTCAGCTCAGTGACAGTGAGGACAGTGACAGTGAACAAACCCCAGAGAAGCCT
CCCTCCTCATCTGCACCTCCAAGTGCTCCACAGTCCCTTCCAGAACCAGTGGCATCAGCACATTCCAGCAGTGCAGAGTCAGAAAGCACC
AGTGACTCAGACAGTTCCTCAGACTCAGAGAGCGAGAGCAGTTCAAGTGACAGCGAAGAAAATGAGCCCCTAGAAACCCCAGCTCCGGAG
CCTGAGCCTCCAACAACAAACAAATGGCAGCTGGACAACTGGCTGACCAAAGTCAGCCAGCCAGCTGCGCCACCAGAGGGCCCCAGGAGC
ACAGAGCCCCCACGGCGGCACCCAGAGAGTAAGGGCAGCAGCGACAGTGCCACGAGTCAGGAGCATTCTGAATCCAAAGATCCTCCCCCT
AAAAGCTCCAGCAAAGCCCCCCGGGCCCCACCCGAAGCCCCCCACCCCGGAAAGAGGAGCTGTCAGAAGTCTCCGGCACAGCAGGAGCCC
CCACAAAGGCAAACCGTTGGAACCAAACAACCCAAAAAACCTGTCAAGGCCTCTGCCCGGGCAGGTTCACGGACCAGCCTGCAGGGGGAA
AGGGAGCCAGGGCTTCTTCCCTATGGCTCCCGAGACCAGACTTCCAAAGACAAGCCCAAGGTGAAGACGAAAGGACGGCCCCGGGCCGCA
GCAAGCAACGAACCCAAGCCAGCAGTGCCCCCCTCCAGTGAGAAGAAGAAGCACAAGAGCTCCCTCCCTGCCCCCTCTAAGGCTCTCTCA
GGCCCAGAACCCGCGAAGGACAATGTGGAGGACAGGACCCCTGAGCACTTTGCTCTTGTTCCCCTGACTGAGAGCCAGGGCCCACCCCAC
AGTGGCAGCGGCAGCAGGACTAGTGGCTGCCGCCAAGCCGTGGTGGTCCAGGAGGACAGCCGCAAAGACAGACTCCCATTGCCTTTGAGA
GACACCAAGCTGCTCTCACCGCTCAGGGACACTCCTCCCCCACAAAGCTTGATGGTGAAGATCACCCTAGACCTGCTCTCTCGGATACCC
CAGCCTCCCGGGAAGGGGAGCCGCCAGAGGAAAGCAGAAGATAAACAGCCGCCCGCAGGGAAGAAGCACAGCTCTGAGAAGAGGAGCTCA
GACAGCTCAAGCAAGTTGGCCAAAAAGAGAAAGGGTGAAGCAGAAAGAGACTGTGATAACAAGAAAATCAGACTGGAGAAGGAAATCAAA
TCACAGTCATCTTCATCTTCATCCTCCCACAAAGAATCTTCTAAAACAAAGCCCTCCAGGCCCTCCTCACAGTCCTCAAAGAAGGAAATG
CTCCCCCCGCCACCCGTGTCCTCGTCCTCCCAGAAGCCAGCCAAGCCTGCACTTAAGAGGTCAAGGCGGGAAGCAGACACCTGTGGCCAG
GACCCTCCCAAAAGTGCCAGCAGTACCAAGAGCAACCACAAAGACTCTTCCATTCCCAAGCAGAGAAGAGTAGAGGGGAAGGGCTCCAGA
AGCTCCTCGGAGCACAAGGGTTCTTCCGGAGATACTGCAAATCCTTTTCCAGTGCCTTCTTTGCCAAATGGTAACTCTAAACCAGGGAAG
CCTCAAGTGAAGTTTGACAAACAACAAGCAGACCTTCACATGAGGGAGGCAAAAAAGATGAAGCAGAAAGCAGAGTTAATGACGGACAGG
GTTGGAAAGGCTTTTAAGTACCTGGAAGCCGTCTTGTCCTTCATTGAGTGCGGAATTGCCACAGAGTCTGAAAGCCAGTCATCCAAGTCA
GCTTACTCTGTCTACTCAGAAACTGTAGATCTCATTAAATTCATAATGTCATTAAAATCCTTCTCAGATGCCACAGCGCCAACACAAGAG
AAAATATTTGCTGTTTTATGCATGCGTTGCCAGTCCATTTTGAACATGGCGATGTTTCGTTGTAAAAAAGACATAGCAATAAAGTATTCT
CGTACTCTTAATAAACACTTCGAGAGTTCTTCCAAAGTCGCCCAGGCACCTTCTCCATGCATTGCAAGAAGCACAGGCACACCATCCCCT
CTTTCCCCAATGCCTTCTCCTGCCAGCTCCGTAGGGTCCCAGTCAAGTGCTGGCAGTGTGGGGAGCAGTGGGGTGGCTGCCACTATCAGC
ACCCCAGTCACCATCCAGAATATGACATCTTCCTATGTCACCATCACATCCCATGTTCTTACCGCCTTTGACCTTTGGGAACAGGCCGAG
GCCCTCACGAGGAAGAATAAAGAATTCTTTGCTCGGCTCAGCACAAATGTGTGCACCTTGGCCCTCAACAGCAGTTTGGTGGACCTGGTG
CACTATACACGACAGGGTTTTCAGCAGCTACAAGAATTAACCAAAACACCTTAATGGAGCCCCAGGTTGATTCAATGCCTTGGGAACTAT
TTTTGCACATTGGAAGCCTCAAAAACAGTCCAGACATTTGTTTCATCAGGACACCAAACTCTAAAAAAGAAGCACCACGAGATGGCCAGG
ACATTTGTCCACTTAAACTCTCAACAACAGTGTGATCATTGGTTGGACACTGTGGTTATGCAGAAGCAGAGATGAGGAGGCTGGCCCCAG
AGATGATCTTGCCCTTCCTAACTAAAGGACAGAAGTGCAATTTAGCTTAAATGGGTGTATGAATGGTCTAGAAACATTTCTATTTTTTTT
TTAAACCAGCAGGATACAAGTTGCAAATGAAATGAGGAGAAACAGTTTCAACTCTGAAAGTGAATTTCACGTCATCTCAGTAGCCACGCT
AGTCCATTCCCAGAAGGAAATTTTTTTTTTTAACAATGACTTTTGGTAAAGGGTTTTGTGGATGATTTTTTTTCTTTTGAGTTTTGGGAG
AAATATTTGTTTAGTAACTTCTAATGGCCATCTGTAAACCATAAGTAATGAAGGACTCCACTGTGCCCCACTTTCTGCCAATGAACAGTG
GCTTGATAATACCAAGTATTGTTGTAATTTATAAAATTGAAGGCAACCCCCGCTCCTGCCGCCCCCAATCTCCCCATTGCCTAGAGCGCT
GCACATTGACCCCAGCTCTGACTTCTCATTACTGTGCTGAAAGTCAGCCCACGTCGGAGCGGTGAGGAGGAGCCACAGCACATGGGGTGC
CACCTCGAGGTCTGCACAGGAGGACTTGGCGCTGCCATTTCCTACCCCTGCCATTTCCCACCCCTGCTTCAGCGAAAGGGACTCTCTAAC
AGGGCAGTCACTGTTGACTCTATTCTGAATTTCCTCCCTTGGGGAAGAAGGGAACCAACATTTATACCTGACCAGATGGCTAAAGTGCTT
TTAAAGTTTTGTTTAAGTAGAGCTGGAATTTGAGGTGCTGATCTGTGGTCTACAGTTATGTGGTAACTCATGTTGTCCAGCCAACTCAGA
GTTTCGTCAGTGAACAAGAAACATGAAATCTGCTTCTTAGAGAGGCTATATTTTTCTGCTACAAATATTTTATATTTATAGCAAAACTAG
ACTTTCAGAGTCCTTGATTGTCTAGGGGAAGTTAACTCCCTGAGAGGATGTAGAGATTTGGGGTGGTTGATTAGACTTTTGAAAAACTCA
TCACCACATGCCTTCACTCCAGAGTGTTCTCAGCTAGATTTGATTTGGTTGAGGAGGAACTGTGGCCCTCCGTAAGTTATTGCCATAGTG
TATGCATTAAACCAAGTCCATTTTGAATGACCTAAAATGAAGTAACACAATCAGAAATCCCATGTGCCCATAAGCACAGATTTTTCTTTT
TCATTGAAACTTTAAAGGTTATTATTGGAAACATTACTTTGAGTGCAGTGTTTTTAAAAGCCAATTCTTTTTTATCCCTTTTAGAAGTAG
AATTTGCACACTTACTACAATTGAGGAGTGTCATCTCTATAACTTTTTCTCCGCCTTTGTCCCATTCTGCCCCTGTACATGTTTCCTACC
AAGCATGTTTCACATTTTCCTATTAGTGGAGGAGGGAGAACCATATTTATTTATAATGAAGACATCTAAGATCCCTATGATGAATGCAGG
AACTCTCTTGGTAGTTTGTAAATACACAAAGGGATGTGTCGAGGGATGGGAGCGATGCTTATCTCTCACAGTGTGAGTGGTCTGTGTGAG
GCTGTTCCTTCAGTTTCTTCTCCAGACTGTTCTTTGGTTGTCACTAAGTCAGAGGTCTGGTCCCTCATGTTTAGGTGAAAGCCAGAGAAT
GACAGCTGTAGTCATATCTGAGCATAAGACCTTGATGTGTGATTCCTGATGACCGGTTTCATTTATTCATGTTATAAAGCAAAGCCCTGG
TCCTTTTTAAACTACTAGTTTTAAAAACCTGTGTTAAATGAACAGTAATTGCCTGGTAGGTTTGGTGTGTGTGTAGCATTGTGTGTCCAT
CTGTTATATGTAAAGGACAAGGCACCAGAATCAGGCTTTATTTCGATATTGAAGATGTTATTTAACATCTTTCTTTTTTCCTTACTCCCT
TAGCCATCCCCTCCCCTTTTGTCCTATCATTCCCTAGAACAAGCCACCTGTCAATTGTGAAGGGTTGTGTTCTTTATGGCAGGTTCTATG
CAGATTGTGCCAGAGCATGTGCGTGTTCTGTTGGCAAGCCACAGTGCTCCCTTGACTGAAGACATTTCCAGGTAGATTTCTCAGCCAGCT
CTAAAACAGATTGCTTTTTCAGTGGCCTTACTCTTTGTGGGTTTTTTTTTTTTTCTCTGAACTTGATATAAAGATTTTATTTGTCCCTTG
AAAAAGTAACAAATGTGCATAGATCAATTTGTACTACTTTGGTCATTGGATATTTCTGATCCTTATTGCATTGTACCTAAAGGAGAGTAA
CTAATGGTAACCTTTTTAATAGAGTATGTGAAAGGTAGTGGCTGATGAATCCTTAACGTTCATAGGGTCTTTTTGCTGTTACGGTTGTAT
ATAGAGGTCTGAAGGATTTTTAAAATGATTTGCACTTTTTCACTGCATGCTTACAATTCCCAAAGGCAAAATCTGTACTGAGGTAGATCA
TTTGAAAGGGCTAGATTATAAAATTAAGCCTTAGAGTATGGAAAGTTCTTATAACAATAATAGTACACACTTCAGAGTAAGACAAATGCA
AAGCATCTTAAGGAGTGAAAATAGAGTGTAAATCTTGCCTTTGGCACTACAAGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTTTA
GTAGGAAATGGAAGAACACTGTTTTATTTTTTAAAGTGTTTAATGTTTCTGTCCTTTCTGTGAATTATTGAATTTAAGAGCCCTGCTAAA
TAATGAAAAAACACTTTACTAAAATTTATCAAATTATACTGGGTTCGGATTGTGAAAACATTGGCCACCTAGTAGCAGTGGTGAGGAGTG
GGAGGGCCCAGCAAGCATTTATCAGAAATAGAATCACAATAGGAGGAGAATTTGACTGTCTGATATTATGATTTGATTACAATACTGAAT
GGGAAAAGTATCTAATATTTTGTAACAAAAAGACCTTCATATTATCTGTTTTGACCAAAATATGTAGCTATTTCCCTTACACAGATTGGA
CCGCACTTATCTCCCTTGTCCTGTATCCTTTAATTTCAGGTCTCAGGATGTTTAGAAAGCTAAAACCCCCTACCCCTTTCTGGCTGAAAA
CTTGCCTTATTTGGTATCTTACACATTAATGTTACTAGCATCAGGAGCTTACTGTTTTATTATGATTCATCTTCAGTAATTTTTAGAAGC
AAGAAGAAAGCCATTGTGTCCTCTACAATTAACAAAACTTATCTCTGATATACAAAGGGATATAAATATATACACTTAAATAGAGAAAAA
GAGGTTGATTGAATTGTGCCTTTGAGTGAACCCAGTTTTTAAATACCGCTGTGTTTGTTTCGCCATGGCTTCAGGGATGCTACATGGCTC
TTGCACCTTTTACTCCTCTGCTTTATGAAGTTTGAGTTGTATTTGTGCATCTTAAAGTAGGTTGAGGCTTGAGGCTGGGCTTTCGGGTTT
TTTTGTTTTTTGTTTTGTTTTGTTTTGTTTTGTTTTCTTGTACTTAAACCTGCTTGCTTCCTACCACAGATTCTTTATTTTCCCAAACAC
TACAAAAAAACTTTTAAAACTTTGCCATTTCATCTGTTTACACTCTTTGCCACTGATTAGCAGTATTTAAATCTTGCAAGAATATTTTGT
GCTTTCTTTAGAAACACAAGAGTATAGATTTTTCTCACTGAAAAGTGAGAGTTACGCATTGCAGCCATGAAGGGATGCTAGGATCAATTA
TGGCAGTACCTTTTTTCCCCTCCTGTTCTTGAGCCAGTTGTCTCTTTTGTTTTGGGTCCCACTTAGGATTAATGGATGTAAGGTATTTTC
CTGTGCCTTTATTTTGTGTCATTCTATTGGAAGGAGGTGTAACGGCAGAATAGCATCGTGTTGGGGGTTTTCCTTCAAACACTGCAAGTG
ATATTGCCACCATGTGAACCTCAAATATGCAATCCAGTTGTGTTGGTTTCTCGGTGACTTGGAGTGTTCATCTCTTCATGAATTGTGAGC
ACTGACCATGTTCTTCAGTTCTTAATTATGGTGAGTTGACAAATACCAACTACTGCTTTTCTTTAGGTGGCTATAAATTTCTTACTGTCA
GGAGGAAATGACATTATATTCTGTTCCACTGAACGTCAGAGATCAGCAGGCACTGTACTGGGTAGAGAAGTGCCTATACTTCTCTACCTA
AGAGGGCAGGAGGGAAACCCTACAGCTCCTTGTGAGCCTATATATTAGTATATCGGCCTGGAGAGGACAAGGGAATAAGACCACTCATAG
TGAGGCTGGCCAAGCTGCACTGGTCGGACCAGGCAGTGGCTGACCTAAGGAAGACAACTTGCTTTGCTTAAAAGTAGATTTTTTAAGCAA
TGCTTAACACAGGCAGCATTCACCTTTGTTCAGGCCATCGACATGTATTGTTAAAATTACTGCATATCCCCCTCAGATATCAAGTATACA
CTGTTCATGTTGGGGTTGTGTGTGTGTATGTGTGTATGTACGCACGCATGTGTCCCAAATCTTGTTTTAATTTTTTTTTTCTGAATGTGA
TCATGTTTTGGATGATACCTGAGCAGGGTTGCCTTTTTTTTATTTATTACCATTATATATTATATTATATTATATTATATATTTTTTGCT
TTCTTATAACTTTGGAGGAAAGTCAAATCTTGGTATTATTAAAATTGTTTTAAAAAGGAGTAAATTTTCCAGTTGATAAATGAAAATCAC
TGGCCTATGTTTAATAAGTTTTTCTTTAATTACTGTGGAATAACGTGCCAGCTATCATCAACACAATGATTTTGTACATAGGGTAGGGAA
GCAGTGATGCTCTCAATGGGAAGATGTGCAACACAAATTAAGGGGAACTCCATGTATTTTACCTACTTCAGCAATGGAACTGCAACTTGG
GGCTTTGTGAATAAAATTTAGCTGCCTTGTATAGTCGTTTGAAAGAATATGTGATCTGTGAGAGAATTATAGTTTTTTTTTAGAAGAAAA
ATCTGCAAAAGATCTTTCCAAAGACAATGTGCCACAGATCTTTTGTTCTCTGTAATGAGGATTAATTGCTGTTTAAACAAAAATGTAATT
GTTCATCTTTAAATTCTTTCCTTTTCATAAGAGGATCAAGCTGTAAAAAAACAAAAAAATTAATAAAAATTTCGAGAAATCATTGGGGTT

>36203_36203_6_HES4-AFF1_HES4_chr1_935246_ENST00000304952_AFF1_chr4_88005272_ENST00000395146_length(amino acids)=901AA_BP=31
MAADTPGKPSASPMAGAPASASRTPDKPRSAAEHRKQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQ
NQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSS
DSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHP
GKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKK
KHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQS
LMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKT
KPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPF
PVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYSETVDLIKFIM
SLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKYSRTLNKHFESSSKVAQAPSPCIARSTGTPSPLSPMPSPASSVGSQSS
AGSVGSSGVAATISTPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLSTNVCTLALNSSLVDLVHYTRQGFQQLQELTKT

--------------------------------------------------------------
>36203_36203_7_HES4-AFF1_HES4_chr1_935246_ENST00000484667_AFF1_chr4_88005272_ENST00000307808_length(transcript)=8048nt_BP=116nt
GGCGCACCATGGCCGCAGACACGCCGGGGAAACCGAGCGCCTCGCCGATGGCAGGAGCGCCGGCCAGCGCCAGCCGGACCCCAGACAAGC
CCCGGAGCGCGGCCGAGCACCGCAAGCAGACCTACTCCAATGAAGTCCATTGTGTTGAAGAGATTCTGAAGGAAATGACCCATTCATGGC
CGCCTCCTTTGACAGCAATACATACGCCTAGTACAGCTGAGCCATCCAAGTTTCCTTTCCCTACAAAGGACTCTCAGCATGTCAGTTCTG
TAACCCAAAACCAAAAACAATATGATACATCTTCAAAAACTCACTCAAATTCTCAGCAAGGAACGTCATCCATGCTCGAAGACGACCTTC
AGCTCAGTGACAGTGAGGACAGTGACAGTGAACAAACCCCAGAGAAGCCTCCCTCCTCATCTGCACCTCCAAGTGCTCCACAGTCCCTTC
CAGAACCAGTGGCATCAGCACATTCCAGCAGTGCAGAGTCAGAAAGCACCAGTGACTCAGACAGTTCCTCAGACTCAGAGAGCGAGAGCA
GTTCAAGTGACAGCGAAGAAAATGAGCCCCTAGAAACCCCAGCTCCGGAGCCTGAGCCTCCAACAACAAACAAATGGCAGCTGGACAACT
GGCTGACCAAAGTCAGCCAGCCAGCTGCGCCACCAGAGGGCCCCAGGAGCACAGAGCCCCCACGGCGGCACCCAGAGAGTAAGGGCAGCA
GCGACAGTGCCACGAGTCAGGAGCATTCTGAATCCAAAGATCCTCCCCCTAAAAGCTCCAGCAAAGCCCCCCGGGCCCCACCCGAAGCCC
CCCACCCCGGAAAGAGGAGCTGTCAGAAGTCTCCGGCACAGCAGGAGCCCCCACAAAGGCAAACCGTTGGAACCAAACAACCCAAAAAAC
CTGTCAAGGCCTCTGCCCGGGCAGGTTCACGGACCAGCCTGCAGGGGGAAAGGGAGCCAGGGCTTCTTCCCTATGGCTCCCGAGACCAGA
CTTCCAAAGACAAGCCCAAGGTGAAGACGAAAGGACGGCCCCGGGCCGCAGCAAGCAACGAACCCAAGCCAGCAGTGCCCCCCTCCAGTG
AGAAGAAGAAGCACAAGAGCTCCCTCCCTGCCCCCTCTAAGGCTCTCTCAGGCCCAGAACCCGCGAAGGACAATGTGGAGGACAGGACCC
CTGAGCACTTTGCTCTTGTTCCCCTGACTGAGAGCCAGGGCCCACCCCACAGTGGCAGCGGCAGCAGGACTAGTGGCTGCCGCCAAGCCG
TGGTGGTCCAGGAGGACAGCCGCAAAGACAGACTCCCATTGCCTTTGAGAGACACCAAGCTGCTCTCACCGCTCAGGGACACTCCTCCCC
CACAAAGCTTGATGGTGAAGATCACCCTAGACCTGCTCTCTCGGATACCCCAGCCTCCCGGGAAGGGGAGCCGCCAGAGGAAAGCAGAAG
ATAAACAGCCGCCCGCAGGGAAGAAGCACAGCTCTGAGAAGAGGAGCTCAGACAGCTCAAGCAAGTTGGCCAAAAAGAGAAAGGGTGAAG
CAGAAAGAGACTGTGATAACAAGAAAATCAGACTGGAGAAGGAAATCAAATCACAGTCATCTTCATCTTCATCCTCCCACAAAGAATCTT
CTAAAACAAAGCCCTCCAGGCCCTCCTCACAGTCCTCAAAGAAGGAAATGCTCCCCCCGCCACCCGTGTCCTCGTCCTCCCAGAAGCCAG
CCAAGCCTGCACTTAAGAGGTCAAGGCGGGAAGCAGACACCTGTGGCCAGGACCCTCCCAAAAGTGCCAGCAGTACCAAGAGCAACCACA
AAGACTCTTCCATTCCCAAGCAGAGAAGAGTAGAGGGGAAGGGCTCCAGAAGCTCCTCGGAGCACAAGGGTTCTTCCGGAGATACTGCAA
ATCCTTTTCCAGTGCCTTCTTTGCCAAATGGTAACTCTAAACCAGGGAAGCCTCAAGTGAAGTTTGACAAACAACAAGCAGACCTTCACA
TGAGGGAGGCAAAAAAGATGAAGCAGAAAGCAGAGTTAATGACGGACAGGGTTGGAAAGGCTTTTAAGTACCTGGAAGCCGTCTTGTCCT
TCATTGAGTGCGGAATTGCCACAGAGTCTGAAAGCCAGTCATCCAAGTCAGCTTACTCTGTCTACTCAGAAACTGTAGATCTCATTAAAT
TCATAATGTCATTAAAATCCTTCTCAGATGCCACAGCGCCAACACAAGAGAAAATATTTGCTGTTTTATGCATGCGTTGCCAGTCCATTT
TGAACATGGCGATGTTTCGTTGTAAAAAAGACATAGCAATAAAGTATTCTCGTACTCTTAATAAACACTTCGAGAGTTCTTCCAAAGTCG
CCCAGGCACCTTCTCCATGCATTGCAAGCACAGGCACACCATCCCCTCTTTCCCCAATGCCTTCTCCTGCCAGCTCCGTAGGGTCCCAGT
CAAGTGCTGGCAGTGTGGGGAGCAGTGGGGTGGCTGCCACTATCAGCACCCCAGTCACCATCCAGAATATGACATCTTCCTATGTCACCA
TCACATCCCATGTTCTTACCGCCTTTGACCTTTGGGAACAGGCCGAGGCCCTCACGAGGAAGAATAAAGAATTCTTTGCTCGGCTCAGCA
CAAATGTGTGCACCTTGGCCCTCAACAGCAGTTTGGTGGACCTGGTGCACTATACACGACAGGGTTTTCAGCAGCTACAAGAATTAACCA
AAACACCTTAATGGAGCCCCAGGTTGATTCAATGCCTTGGGAACTATTTTTGCACATTGGAAGCCTCAAAAACAGTCCAGACATTTGTTT
CATCAGGACACCAAACTCTAAAAAAGAAGCACCACGAGATGGCCAGGACATTTGTCCACTTAAACTCTCAACAACAGTGTGATCATTGGT
TGGACACTGTGGTTATGCAGAAGCAGAGATGAGGAGGCTGGCCCCAGAGATGATCTTGCCCTTCCTAACTAAAGGACAGAAGTGCAATTT
AGCTTAAATGGGTGTATGAATGGTCTAGAAACATTTCTATTTTTTTTTTAAACCAGCAGGATACAAGTTGCAAATGAAATGAGGAGAAAC
AGTTTCAACTCTGAAAGTGAATTTCACGTCATCTCAGTAGCCACGCTAGTCCATTCCCAGAAGGAAATTTTTTTTTTTAACAATGACTTT
TGGTAAAGGGTTTTGTGGATGATTTTTTTTCTTTTGAGTTTTGGGAGAAATATTTGTTTAGTAACTTCTAATGGCCATCTGTAAACCATA
AGTAATGAAGGACTCCACTGTGCCCCACTTTCTGCCAATGAACAGTGGCTTGATAATACCAAGTATTGTTGTAATTTATAAAATTGAAGG
CAACCCCCGCTCCTGCCGCCCCCAATCTCCCCATTGCCTAGAGCGCTGCACATTGACCCCAGCTCTGACTTCTCATTACTGTGCTGAAAG
TCAGCCCACGTCGGAGCGGTGAGGAGGAGCCACAGCACATGGGGTGCCACCTCGAGGTCTGCACAGGAGGACTTGGCGCTGCCATTTCCT
ACCCCTGCCATTTCCCACCCCTGCTTCAGCGAAAGGGACTCTCTAACAGGGCAGTCACTGTTGACTCTATTCTGAATTTCCTCCCTTGGG
GAAGAAGGGAACCAACATTTATACCTGACCAGATGGCTAAAGTGCTTTTAAAGTTTTGTTTAAGTAGAGCTGGAATTTGAGGTGCTGATC
TGTGGTCTACAGTTATGTGGTAACTCATGTTGTCCAGCCAACTCAGAGTTTCGTCAGTGAACAAGAAACATGAAATCTGCTTCTTAGAGA
GGCTATATTTTTCTGCTACAAATATTTTATATTTATAGCAAAACTAGACTTTCAGAGTCCTTGATTGTCTAGGGGAAGTTAACTCCCTGA
GAGGATGTAGAGATTTGGGGTGGTTGATTAGACTTTTGAAAAACTCATCACCACATGCCTTCACTCCAGAGTGTTCTCAGCTAGATTTGA
TTTGGTTGAGGAGGAACTGTGGCCCTCCGTAAGTTATTGCCATAGTGTATGCATTAAACCAAGTCCATTTTGAATGACCTAAAATGAAGT
AACACAATCAGAAATCCCATGTGCCCATAAGCACAGATTTTTCTTTTTCATTGAAACTTTAAAGGTTATTATTGGAAACATTACTTTGAG
TGCAGTGTTTTTAAAAGCCAATTCTTTTTTATCCCTTTTAGAAGTAGAATTTGCACACTTACTACAATTGAGGAGTGTCATCTCTATAAC
TTTTTCTCCGCCTTTGTCCCATTCTGCCCCTGTACATGTTTCCTACCAAGCATGTTTCACATTTTCCTATTAGTGGAGGAGGGAGAACCA
TATTTATTTATAATGAAGACATCTAAGATCCCTATGATGAATGCAGGAACTCTCTTGGTAGTTTGTAAATACACAAAGGGATGTGTCGAG
GGATGGGAGCGATGCTTATCTCTCACAGTGTGAGTGGTCTGTGTGAGGCTGTTCCTTCAGTTTCTTCTCCAGACTGTTCTTTGGTTGTCA
CTAAGTCAGAGGTCTGGTCCCTCATGTTTAGGTGAAAGCCAGAGAATGACAGCTGTAGTCATATCTGAGCATAAGACCTTGATGTGTGAT
TCCTGATGACCGGTTTCATTTATTCATGTTATAAAGCAAAGCCCTGGTCCTTTTTAAACTACTAGTTTTAAAAACCTGTGTTAAATGAAC
AGTAATTGCCTGGTAGGTTTGGTGTGTGTGTAGCATTGTGTGTCCATCTGTTATATGTAAAGGACAAGGCACCAGAATCAGGCTTTATTT
CGATATTGAAGATGTTATTTAACATCTTTCTTTTTTCCTTACTCCCTTAGCCATCCCCTCCCCTTTTGTCCTATCATTCCCTAGAACAAG
CCACCTGTCAATTGTGAAGGGTTGTGTTCTTTATGGCAGGTTCTATGCAGATTGTGCCAGAGCATGTGCGTGTTCTGTTGGCAAGCCACA
GTGCTCCCTTGACTGAAGACATTTCCAGGTAGATTTCTCAGCCAGCTCTAAAACAGATTGCTTTTTCAGTGGCCTTACTCTTTGTGGGTT
TTTTTTTTTTTCTCTGAACTTGATATAAAGATTTTATTTGTCCCTTGAAAAAGTAACAAATGTGCATAGATCAATTTGTACTACTTTGGT
CATTGGATATTTCTGATCCTTATTGCATTGTACCTAAAGGAGAGTAACTAATGGTAACCTTTTTAATAGAGTATGTGAAAGGTAGTGGCT
GATGAATCCTTAACGTTCATAGGGTCTTTTTGCTGTTACGGTTGTATATAGAGGTCTGAAGGATTTTTAAAATGATTTGCACTTTTTCAC
TGCATGCTTACAATTCCCAAAGGCAAAATCTGTACTGAGGTAGATCATTTGAAAGGGCTAGATTATAAAATTAAGCCTTAGAGTATGGAA
AGTTCTTATAACAATAATAGTACACACTTCAGAGTAAGACAAATGCAAAGCATCTTAAGGAGTGAAAATAGAGTGTAAATCTTGCCTTTG
GCACTACAAGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTTTAGTAGGAAATGGAAGAACACTGTTTTATTTTTTAAAGTGTTTAA
TGTTTCTGTCCTTTCTGTGAATTATTGAATTTAAGAGCCCTGCTAAATAATGAAAAAACACTTTACTAAAATTTATCAAATTATACTGGG
TTCGGATTGTGAAAACATTGGCCACCTAGTAGCAGTGGTGAGGAGTGGGAGGGCCCAGCAAGCATTTATCAGAAATAGAATCACAATAGG
AGGAGAATTTGACTGTCTGATATTATGATTTGATTACAATACTGAATGGGAAAAGTATCTAATATTTTGTAACAAAAAGACCTTCATATT
ATCTGTTTTGACCAAAATATGTAGCTATTTCCCTTACACAGATTGGACCGCACTTATCTCCCTTGTCCTGTATCCTTTAATTTCAGGTCT
CAGGATGTTTAGAAAGCTAAAACCCCCTACCCCTTTCTGGCTGAAAACTTGCCTTATTTGGTATCTTACACATTAATGTTACTAGCATCA
GGAGCTTACTGTTTTATTATGATTCATCTTCAGTAATTTTTAGAAGCAAGAAGAAAGCCATTGTGTCCTCTACAATTAACAAAACTTATC
TCTGATATACAAAGGGATATAAATATATACACTTAAATAGAGAAAAAGAGGTTGATTGAATTGTGCCTTTGAGTGAACCCAGTTTTTAAA
TACCGCTGTGTTTGTTTCGCCATGGCTTCAGGGATGCTACATGGCTCTTGCACCTTTTACTCCTCTGCTTTATGAAGTTTGAGTTGTATT
TGTGCATCTTAAAGTAGGTTGAGGCTTGAGGCTGGGCTTTCGGGTTTTTTTGTTTTTTGTTTTGTTTTGTTTTGTTTTGTTTTCTTGTAC
TTAAACCTGCTTGCTTCCTACCACAGATTCTTTATTTTCCCAAACACTACAAAAAAACTTTTAAAACTTTGCCATTTCATCTGTTTACAC
TCTTTGCCACTGATTAGCAGTATTTAAATCTTGCAAGAATATTTTGTGCTTTCTTTAGAAACACAAGAGTATAGATTTTTCTCACTGAAA
AGTGAGAGTTACGCATTGCAGCCATGAAGGGATGCTAGGATCAATTATGGCAGTACCTTTTTTCCCCTCCTGTTCTTGAGCCAGTTGTCT
CTTTTGTTTTGGGTCCCACTTAGGATTAATGGATGTAAGGTATTTTCCTGTGCCTTTATTTTGTGTCATTCTATTGGAAGGAGGTGTAAC
GGCAGAATAGCATCGTGTTGGGGGTTTTCCTTCAAACACTGCAAGTGATATTGCCACCATGTGAACCTCAAATATGCAATCCAGTTGTGT
TGGTTTCTCGGTGACTTGGAGTGTTCATCTCTTCATGAATTGTGAGCACTGACCATGTTCTTCAGTTCTTAATTATGGTGAGTTGACAAA
TACCAACTACTGCTTTTCTTTAGGTGGCTATAAATTTCTTACTGTCAGGAGGAAATGACATTATATTCTGTTCCACTGAACGTCAGAGAT
CAGCAGGCACTGTACTGGGTAGAGAAGTGCCTATACTTCTCTACCTAAGAGGGCAGGAGGGAAACCCTACAGCTCCTTGTGAGCCTATAT
ATTAGTATATCGGCCTGGAGAGGACAAGGGAATAAGACCACTCATAGTGAGGCTGGCCAAGCTGCACTGGTCGGACCAGGCAGTGGCTGA
CCTAAGGAAGACAACTTGCTTTGCTTAAAAGTAGATTTTTTAAGCAATGCTTAACACAGGCAGCATTCACCTTTGTTCAGGCCATCGACA
TGTATTGTTAAAATTACTGCATATCCCCCTCAGATATCAAGTATACACTGTTCATGTTGGGGTTGTGTGTGTGTATGTGTGTATGTACGC
ACGCATGTGTCCCAAATCTTGTTTTAATTTTTTTTTTCTGAATGTGATCATGTTTTGGATGATACCTGAGCAGGGTTGCCTTTTTTTTAT
TTATTACCATTATATATTATATTATATTATATTATATATTTTTTGCTTTCTTATAACTTTGGAGGAAAGTCAAATCTTGGTATTATTAAA
ATTGTTTTAAAAAGGAGTAAATTTTCCAGTTGATAAATGAAAATCACTGGCCTATGTTTAATAAGTTTTTCTTTAATTACTGTGGAATAA
CGTGCCAGCTATCATCAACACAATGATTTTGTACATAGGGTAGGGAAGCAGTGATGCTCTCAATGGGAAGATGTGCAACACAAATTAAGG
GGAACTCCATGTATTTTACCTACTTCAGCAATGGAACTGCAACTTGGGGCTTTGTGAATAAAATTTAGCTGCCTTGTATAGTCGTTTGAA
AGAATATGTGATCTGTGAGAGAATTATAGTTTTTTTTTAGAAGAAAAATCTGCAAAAGATCTTTCCAAAGACAATGTGCCACAGATCTTT
TGTTCTCTGTAATGAGGATTAATTGCTGTTTAAACAAAAATGTAATTGTTCATCTTTAAATTCTTTCCTTTTCATAAGAGGATCAAGCTG

>36203_36203_7_HES4-AFF1_HES4_chr1_935246_ENST00000484667_AFF1_chr4_88005272_ENST00000307808_length(amino acids)=900AA_BP=31
MAADTPGKPSASPMAGAPASASRTPDKPRSAAEHRKQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQ
NQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSS
DSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHP
GKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKK
KHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQS
LMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKT
KPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPF
PVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYSETVDLIKFIM
SLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKYSRTLNKHFESSSKVAQAPSPCIASTGTPSPLSPMPSPASSVGSQSSA
GSVGSSGVAATISTPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLSTNVCTLALNSSLVDLVHYTRQGFQQLQELTKTP

--------------------------------------------------------------
>36203_36203_8_HES4-AFF1_HES4_chr1_935246_ENST00000484667_AFF1_chr4_88005272_ENST00000395146_length(transcript)=8067nt_BP=116nt
GGCGCACCATGGCCGCAGACACGCCGGGGAAACCGAGCGCCTCGCCGATGGCAGGAGCGCCGGCCAGCGCCAGCCGGACCCCAGACAAGC
CCCGGAGCGCGGCCGAGCACCGCAAGCAGACCTACTCCAATGAAGTCCATTGTGTTGAAGAGATTCTGAAGGAAATGACCCATTCATGGC
CGCCTCCTTTGACAGCAATACATACGCCTAGTACAGCTGAGCCATCCAAGTTTCCTTTCCCTACAAAGGACTCTCAGCATGTCAGTTCTG
TAACCCAAAACCAAAAACAATATGATACATCTTCAAAAACTCACTCAAATTCTCAGCAAGGAACGTCATCCATGCTCGAAGACGACCTTC
AGCTCAGTGACAGTGAGGACAGTGACAGTGAACAAACCCCAGAGAAGCCTCCCTCCTCATCTGCACCTCCAAGTGCTCCACAGTCCCTTC
CAGAACCAGTGGCATCAGCACATTCCAGCAGTGCAGAGTCAGAAAGCACCAGTGACTCAGACAGTTCCTCAGACTCAGAGAGCGAGAGCA
GTTCAAGTGACAGCGAAGAAAATGAGCCCCTAGAAACCCCAGCTCCGGAGCCTGAGCCTCCAACAACAAACAAATGGCAGCTGGACAACT
GGCTGACCAAAGTCAGCCAGCCAGCTGCGCCACCAGAGGGCCCCAGGAGCACAGAGCCCCCACGGCGGCACCCAGAGAGTAAGGGCAGCA
GCGACAGTGCCACGAGTCAGGAGCATTCTGAATCCAAAGATCCTCCCCCTAAAAGCTCCAGCAAAGCCCCCCGGGCCCCACCCGAAGCCC
CCCACCCCGGAAAGAGGAGCTGTCAGAAGTCTCCGGCACAGCAGGAGCCCCCACAAAGGCAAACCGTTGGAACCAAACAACCCAAAAAAC
CTGTCAAGGCCTCTGCCCGGGCAGGTTCACGGACCAGCCTGCAGGGGGAAAGGGAGCCAGGGCTTCTTCCCTATGGCTCCCGAGACCAGA
CTTCCAAAGACAAGCCCAAGGTGAAGACGAAAGGACGGCCCCGGGCCGCAGCAAGCAACGAACCCAAGCCAGCAGTGCCCCCCTCCAGTG
AGAAGAAGAAGCACAAGAGCTCCCTCCCTGCCCCCTCTAAGGCTCTCTCAGGCCCAGAACCCGCGAAGGACAATGTGGAGGACAGGACCC
CTGAGCACTTTGCTCTTGTTCCCCTGACTGAGAGCCAGGGCCCACCCCACAGTGGCAGCGGCAGCAGGACTAGTGGCTGCCGCCAAGCCG
TGGTGGTCCAGGAGGACAGCCGCAAAGACAGACTCCCATTGCCTTTGAGAGACACCAAGCTGCTCTCACCGCTCAGGGACACTCCTCCCC
CACAAAGCTTGATGGTGAAGATCACCCTAGACCTGCTCTCTCGGATACCCCAGCCTCCCGGGAAGGGGAGCCGCCAGAGGAAAGCAGAAG
ATAAACAGCCGCCCGCAGGGAAGAAGCACAGCTCTGAGAAGAGGAGCTCAGACAGCTCAAGCAAGTTGGCCAAAAAGAGAAAGGGTGAAG
CAGAAAGAGACTGTGATAACAAGAAAATCAGACTGGAGAAGGAAATCAAATCACAGTCATCTTCATCTTCATCCTCCCACAAAGAATCTT
CTAAAACAAAGCCCTCCAGGCCCTCCTCACAGTCCTCAAAGAAGGAAATGCTCCCCCCGCCACCCGTGTCCTCGTCCTCCCAGAAGCCAG
CCAAGCCTGCACTTAAGAGGTCAAGGCGGGAAGCAGACACCTGTGGCCAGGACCCTCCCAAAAGTGCCAGCAGTACCAAGAGCAACCACA
AAGACTCTTCCATTCCCAAGCAGAGAAGAGTAGAGGGGAAGGGCTCCAGAAGCTCCTCGGAGCACAAGGGTTCTTCCGGAGATACTGCAA
ATCCTTTTCCAGTGCCTTCTTTGCCAAATGGTAACTCTAAACCAGGGAAGCCTCAAGTGAAGTTTGACAAACAACAAGCAGACCTTCACA
TGAGGGAGGCAAAAAAGATGAAGCAGAAAGCAGAGTTAATGACGGACAGGGTTGGAAAGGCTTTTAAGTACCTGGAAGCCGTCTTGTCCT
TCATTGAGTGCGGAATTGCCACAGAGTCTGAAAGCCAGTCATCCAAGTCAGCTTACTCTGTCTACTCAGAAACTGTAGATCTCATTAAAT
TCATAATGTCATTAAAATCCTTCTCAGATGCCACAGCGCCAACACAAGAGAAAATATTTGCTGTTTTATGCATGCGTTGCCAGTCCATTT
TGAACATGGCGATGTTTCGTTGTAAAAAAGACATAGCAATAAAGTATTCTCGTACTCTTAATAAACACTTCGAGAGTTCTTCCAAAGTCG
CCCAGGCACCTTCTCCATGCATTGCAAGAAGCACAGGCACACCATCCCCTCTTTCCCCAATGCCTTCTCCTGCCAGCTCCGTAGGGTCCC
AGTCAAGTGCTGGCAGTGTGGGGAGCAGTGGGGTGGCTGCCACTATCAGCACCCCAGTCACCATCCAGAATATGACATCTTCCTATGTCA
CCATCACATCCCATGTTCTTACCGCCTTTGACCTTTGGGAACAGGCCGAGGCCCTCACGAGGAAGAATAAAGAATTCTTTGCTCGGCTCA
GCACAAATGTGTGCACCTTGGCCCTCAACAGCAGTTTGGTGGACCTGGTGCACTATACACGACAGGGTTTTCAGCAGCTACAAGAATTAA
CCAAAACACCTTAATGGAGCCCCAGGTTGATTCAATGCCTTGGGAACTATTTTTGCACATTGGAAGCCTCAAAAACAGTCCAGACATTTG
TTTCATCAGGACACCAAACTCTAAAAAAGAAGCACCACGAGATGGCCAGGACATTTGTCCACTTAAACTCTCAACAACAGTGTGATCATT
GGTTGGACACTGTGGTTATGCAGAAGCAGAGATGAGGAGGCTGGCCCCAGAGATGATCTTGCCCTTCCTAACTAAAGGACAGAAGTGCAA
TTTAGCTTAAATGGGTGTATGAATGGTCTAGAAACATTTCTATTTTTTTTTTAAACCAGCAGGATACAAGTTGCAAATGAAATGAGGAGA
AACAGTTTCAACTCTGAAAGTGAATTTCACGTCATCTCAGTAGCCACGCTAGTCCATTCCCAGAAGGAAATTTTTTTTTTTAACAATGAC
TTTTGGTAAAGGGTTTTGTGGATGATTTTTTTTCTTTTGAGTTTTGGGAGAAATATTTGTTTAGTAACTTCTAATGGCCATCTGTAAACC
ATAAGTAATGAAGGACTCCACTGTGCCCCACTTTCTGCCAATGAACAGTGGCTTGATAATACCAAGTATTGTTGTAATTTATAAAATTGA
AGGCAACCCCCGCTCCTGCCGCCCCCAATCTCCCCATTGCCTAGAGCGCTGCACATTGACCCCAGCTCTGACTTCTCATTACTGTGCTGA
AAGTCAGCCCACGTCGGAGCGGTGAGGAGGAGCCACAGCACATGGGGTGCCACCTCGAGGTCTGCACAGGAGGACTTGGCGCTGCCATTT
CCTACCCCTGCCATTTCCCACCCCTGCTTCAGCGAAAGGGACTCTCTAACAGGGCAGTCACTGTTGACTCTATTCTGAATTTCCTCCCTT
GGGGAAGAAGGGAACCAACATTTATACCTGACCAGATGGCTAAAGTGCTTTTAAAGTTTTGTTTAAGTAGAGCTGGAATTTGAGGTGCTG
ATCTGTGGTCTACAGTTATGTGGTAACTCATGTTGTCCAGCCAACTCAGAGTTTCGTCAGTGAACAAGAAACATGAAATCTGCTTCTTAG
AGAGGCTATATTTTTCTGCTACAAATATTTTATATTTATAGCAAAACTAGACTTTCAGAGTCCTTGATTGTCTAGGGGAAGTTAACTCCC
TGAGAGGATGTAGAGATTTGGGGTGGTTGATTAGACTTTTGAAAAACTCATCACCACATGCCTTCACTCCAGAGTGTTCTCAGCTAGATT
TGATTTGGTTGAGGAGGAACTGTGGCCCTCCGTAAGTTATTGCCATAGTGTATGCATTAAACCAAGTCCATTTTGAATGACCTAAAATGA
AGTAACACAATCAGAAATCCCATGTGCCCATAAGCACAGATTTTTCTTTTTCATTGAAACTTTAAAGGTTATTATTGGAAACATTACTTT
GAGTGCAGTGTTTTTAAAAGCCAATTCTTTTTTATCCCTTTTAGAAGTAGAATTTGCACACTTACTACAATTGAGGAGTGTCATCTCTAT
AACTTTTTCTCCGCCTTTGTCCCATTCTGCCCCTGTACATGTTTCCTACCAAGCATGTTTCACATTTTCCTATTAGTGGAGGAGGGAGAA
CCATATTTATTTATAATGAAGACATCTAAGATCCCTATGATGAATGCAGGAACTCTCTTGGTAGTTTGTAAATACACAAAGGGATGTGTC
GAGGGATGGGAGCGATGCTTATCTCTCACAGTGTGAGTGGTCTGTGTGAGGCTGTTCCTTCAGTTTCTTCTCCAGACTGTTCTTTGGTTG
TCACTAAGTCAGAGGTCTGGTCCCTCATGTTTAGGTGAAAGCCAGAGAATGACAGCTGTAGTCATATCTGAGCATAAGACCTTGATGTGT
GATTCCTGATGACCGGTTTCATTTATTCATGTTATAAAGCAAAGCCCTGGTCCTTTTTAAACTACTAGTTTTAAAAACCTGTGTTAAATG
AACAGTAATTGCCTGGTAGGTTTGGTGTGTGTGTAGCATTGTGTGTCCATCTGTTATATGTAAAGGACAAGGCACCAGAATCAGGCTTTA
TTTCGATATTGAAGATGTTATTTAACATCTTTCTTTTTTCCTTACTCCCTTAGCCATCCCCTCCCCTTTTGTCCTATCATTCCCTAGAAC
AAGCCACCTGTCAATTGTGAAGGGTTGTGTTCTTTATGGCAGGTTCTATGCAGATTGTGCCAGAGCATGTGCGTGTTCTGTTGGCAAGCC
ACAGTGCTCCCTTGACTGAAGACATTTCCAGGTAGATTTCTCAGCCAGCTCTAAAACAGATTGCTTTTTCAGTGGCCTTACTCTTTGTGG
GTTTTTTTTTTTTTCTCTGAACTTGATATAAAGATTTTATTTGTCCCTTGAAAAAGTAACAAATGTGCATAGATCAATTTGTACTACTTT
GGTCATTGGATATTTCTGATCCTTATTGCATTGTACCTAAAGGAGAGTAACTAATGGTAACCTTTTTAATAGAGTATGTGAAAGGTAGTG
GCTGATGAATCCTTAACGTTCATAGGGTCTTTTTGCTGTTACGGTTGTATATAGAGGTCTGAAGGATTTTTAAAATGATTTGCACTTTTT
CACTGCATGCTTACAATTCCCAAAGGCAAAATCTGTACTGAGGTAGATCATTTGAAAGGGCTAGATTATAAAATTAAGCCTTAGAGTATG
GAAAGTTCTTATAACAATAATAGTACACACTTCAGAGTAAGACAAATGCAAAGCATCTTAAGGAGTGAAAATAGAGTGTAAATCTTGCCT
TTGGCACTACAAGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTTTAGTAGGAAATGGAAGAACACTGTTTTATTTTTTAAAGTGTT
TAATGTTTCTGTCCTTTCTGTGAATTATTGAATTTAAGAGCCCTGCTAAATAATGAAAAAACACTTTACTAAAATTTATCAAATTATACT
GGGTTCGGATTGTGAAAACATTGGCCACCTAGTAGCAGTGGTGAGGAGTGGGAGGGCCCAGCAAGCATTTATCAGAAATAGAATCACAAT
AGGAGGAGAATTTGACTGTCTGATATTATGATTTGATTACAATACTGAATGGGAAAAGTATCTAATATTTTGTAACAAAAAGACCTTCAT
ATTATCTGTTTTGACCAAAATATGTAGCTATTTCCCTTACACAGATTGGACCGCACTTATCTCCCTTGTCCTGTATCCTTTAATTTCAGG
TCTCAGGATGTTTAGAAAGCTAAAACCCCCTACCCCTTTCTGGCTGAAAACTTGCCTTATTTGGTATCTTACACATTAATGTTACTAGCA
TCAGGAGCTTACTGTTTTATTATGATTCATCTTCAGTAATTTTTAGAAGCAAGAAGAAAGCCATTGTGTCCTCTACAATTAACAAAACTT
ATCTCTGATATACAAAGGGATATAAATATATACACTTAAATAGAGAAAAAGAGGTTGATTGAATTGTGCCTTTGAGTGAACCCAGTTTTT
AAATACCGCTGTGTTTGTTTCGCCATGGCTTCAGGGATGCTACATGGCTCTTGCACCTTTTACTCCTCTGCTTTATGAAGTTTGAGTTGT
ATTTGTGCATCTTAAAGTAGGTTGAGGCTTGAGGCTGGGCTTTCGGGTTTTTTTGTTTTTTGTTTTGTTTTGTTTTGTTTTGTTTTCTTG
TACTTAAACCTGCTTGCTTCCTACCACAGATTCTTTATTTTCCCAAACACTACAAAAAAACTTTTAAAACTTTGCCATTTCATCTGTTTA
CACTCTTTGCCACTGATTAGCAGTATTTAAATCTTGCAAGAATATTTTGTGCTTTCTTTAGAAACACAAGAGTATAGATTTTTCTCACTG
AAAAGTGAGAGTTACGCATTGCAGCCATGAAGGGATGCTAGGATCAATTATGGCAGTACCTTTTTTCCCCTCCTGTTCTTGAGCCAGTTG
TCTCTTTTGTTTTGGGTCCCACTTAGGATTAATGGATGTAAGGTATTTTCCTGTGCCTTTATTTTGTGTCATTCTATTGGAAGGAGGTGT
AACGGCAGAATAGCATCGTGTTGGGGGTTTTCCTTCAAACACTGCAAGTGATATTGCCACCATGTGAACCTCAAATATGCAATCCAGTTG
TGTTGGTTTCTCGGTGACTTGGAGTGTTCATCTCTTCATGAATTGTGAGCACTGACCATGTTCTTCAGTTCTTAATTATGGTGAGTTGAC
AAATACCAACTACTGCTTTTCTTTAGGTGGCTATAAATTTCTTACTGTCAGGAGGAAATGACATTATATTCTGTTCCACTGAACGTCAGA
GATCAGCAGGCACTGTACTGGGTAGAGAAGTGCCTATACTTCTCTACCTAAGAGGGCAGGAGGGAAACCCTACAGCTCCTTGTGAGCCTA
TATATTAGTATATCGGCCTGGAGAGGACAAGGGAATAAGACCACTCATAGTGAGGCTGGCCAAGCTGCACTGGTCGGACCAGGCAGTGGC
TGACCTAAGGAAGACAACTTGCTTTGCTTAAAAGTAGATTTTTTAAGCAATGCTTAACACAGGCAGCATTCACCTTTGTTCAGGCCATCG
ACATGTATTGTTAAAATTACTGCATATCCCCCTCAGATATCAAGTATACACTGTTCATGTTGGGGTTGTGTGTGTGTATGTGTGTATGTA
CGCACGCATGTGTCCCAAATCTTGTTTTAATTTTTTTTTTCTGAATGTGATCATGTTTTGGATGATACCTGAGCAGGGTTGCCTTTTTTT
TATTTATTACCATTATATATTATATTATATTATATTATATATTTTTTGCTTTCTTATAACTTTGGAGGAAAGTCAAATCTTGGTATTATT
AAAATTGTTTTAAAAAGGAGTAAATTTTCCAGTTGATAAATGAAAATCACTGGCCTATGTTTAATAAGTTTTTCTTTAATTACTGTGGAA
TAACGTGCCAGCTATCATCAACACAATGATTTTGTACATAGGGTAGGGAAGCAGTGATGCTCTCAATGGGAAGATGTGCAACACAAATTA
AGGGGAACTCCATGTATTTTACCTACTTCAGCAATGGAACTGCAACTTGGGGCTTTGTGAATAAAATTTAGCTGCCTTGTATAGTCGTTT
GAAAGAATATGTGATCTGTGAGAGAATTATAGTTTTTTTTTAGAAGAAAAATCTGCAAAAGATCTTTCCAAAGACAATGTGCCACAGATC
TTTTGTTCTCTGTAATGAGGATTAATTGCTGTTTAAACAAAAATGTAATTGTTCATCTTTAAATTCTTTCCTTTTCATAAGAGGATCAAG

>36203_36203_8_HES4-AFF1_HES4_chr1_935246_ENST00000484667_AFF1_chr4_88005272_ENST00000395146_length(amino acids)=901AA_BP=31
MAADTPGKPSASPMAGAPASASRTPDKPRSAAEHRKQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQ
NQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSS
DSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHP
GKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKK
KHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQS
LMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKT
KPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPF
PVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYSETVDLIKFIM
SLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKYSRTLNKHFESSSKVAQAPSPCIARSTGTPSPLSPMPSPASSVGSQSS
AGSVGSSGVAATISTPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLSTNVCTLALNSSLVDLVHYTRQGFQQLQELTKT

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Fusion Gene PPI Analysis for HES4-AFF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HES4-AFF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HES4-AFF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource