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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BAX-ISLR (FusionGDB2 ID:HG581TG3671)

Fusion Gene Summary for BAX-ISLR

check button Fusion gene summary
Fusion gene informationFusion gene name: BAX-ISLR
Fusion gene ID: hg581tg3671
HgeneTgene
Gene symbol

BAX

ISLR

Gene ID

581

3671

Gene nameBCL2 associated X, apoptosis regulatorimmunoglobulin superfamily containing leucine rich repeat
SynonymsBCL2L4HsT17563|Meflin
Cytomap('BAX')('ISLR')

19q13.33

15q24.1

Type of geneprotein-codingprotein-coding
Descriptionapoptosis regulator BAXBCL2 associated X proteinBCL2-associated X protein omegaBaxdelta2G9Baxdelta2G9omegaBaxdelta2omegabcl-2-like protein 4bcl2-L-4immunoglobulin superfamily containing leucine-rich repeat proteinmesenchymal stromal cell- and fibroblast-expressing Linx paralogue
Modification date2020032220200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000391871, ENST00000293288, 
ENST00000345358, ENST00000415969, 
ENST00000539787, ENST00000354470, 
Fusion gene scores* DoF score6 X 5 X 5=1506 X 7 X 3=126
# samples 77
** MAII scorelog2(7/150*10)=-1.09953567355091
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BAX [Title/Abstract] AND ISLR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBAX(49459090)-ISLR(74468295), # samples:1
Anticipated loss of major functional domain due to fusion event.BAX-ISLR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BAX-ISLR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BAX-ISLR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BAX-ISLR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBAX

GO:0001783

B cell apoptotic process

15214043|16424160

HgeneBAX

GO:0001836

release of cytochrome c from mitochondria

9843949|16199525|17052454

HgeneBAX

GO:0006915

apoptotic process

9660918

HgeneBAX

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

11912183

HgeneBAX

GO:0008053

mitochondrial fusion

14769861

HgeneBAX

GO:0008635

activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c

15214043

HgeneBAX

GO:0008637

apoptotic mitochondrial changes

9843949

HgeneBAX

GO:0009636

response to toxic substance

16307838

HgeneBAX

GO:0010248

establishment or maintenance of transmembrane electrochemical gradient

9843949

HgeneBAX

GO:0010917

negative regulation of mitochondrial membrane potential

16751333

HgeneBAX

GO:0031334

positive regulation of protein complex assembly

9111042|19805544

HgeneBAX

GO:0032091

negative regulation of protein binding

9388232

HgeneBAX

GO:0032976

release of matrix enzymes from mitochondria

9843949

HgeneBAX

GO:0043065

positive regulation of apoptotic process

16751333|17464193

HgeneBAX

GO:0043525

positive regulation of neuron apoptotic process

15637643

HgeneBAX

GO:0043653

mitochondrial fragmentation involved in apoptotic process

12499352

HgeneBAX

GO:0051881

regulation of mitochondrial membrane potential

9843949

HgeneBAX

GO:0090200

positive regulation of release of cytochrome c from mitochondria

14963330

HgeneBAX

GO:0097190

apoptotic signaling pathway

16424160

HgeneBAX

GO:0097191

extrinsic apoptotic signaling pathway

15214043

HgeneBAX

GO:0097193

intrinsic apoptotic signaling pathway

9219694|16462759

HgeneBAX

GO:1990117

B cell receptor apoptotic signaling pathway

15214043


check buttonFusion gene breakpoints across BAX (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ISLR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8284-01ABAXchr19

49459090

+ISLRchr15

74468295

+


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Fusion Gene ORF analysis for BAX-ISLR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000391871ENST00000249842BAXchr19

49459090

+ISLRchr15

74468295

+
3UTR-3CDSENST00000391871ENST00000395118BAXchr19

49459090

+ISLRchr15

74468295

+
In-frameENST00000293288ENST00000249842BAXchr19

49459090

+ISLRchr15

74468295

+
In-frameENST00000293288ENST00000395118BAXchr19

49459090

+ISLRchr15

74468295

+
In-frameENST00000345358ENST00000249842BAXchr19

49459090

+ISLRchr15

74468295

+
In-frameENST00000345358ENST00000395118BAXchr19

49459090

+ISLRchr15

74468295

+
In-frameENST00000415969ENST00000249842BAXchr19

49459090

+ISLRchr15

74468295

+
In-frameENST00000415969ENST00000395118BAXchr19

49459090

+ISLRchr15

74468295

+
In-frameENST00000539787ENST00000249842BAXchr19

49459090

+ISLRchr15

74468295

+
In-frameENST00000539787ENST00000395118BAXchr19

49459090

+ISLRchr15

74468295

+
intron-3CDSENST00000354470ENST00000249842BAXchr19

49459090

+ISLRchr15

74468295

+
intron-3CDSENST00000354470ENST00000395118BAXchr19

49459090

+ISLRchr15

74468295

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000539787BAXchr1949459090+ENST00000249842ISLRchr1574468295+122030218323101
ENST00000539787BAXchr1949459090+ENST00000395118ISLRchr1574468295+122030218323101
ENST00000345358BAXchr1949459090+ENST00000249842ISLRchr1574468295+12032851306101
ENST00000345358BAXchr1949459090+ENST00000395118ISLRchr1574468295+12032851306101
ENST00000415969BAXchr1949459090+ENST00000249842ISLRchr1574468295+1151233251553100
ENST00000415969BAXchr1949459090+ENST00000395118ISLRchr1574468295+1151233251553100
ENST00000293288BAXchr1949459090+ENST00000249842ISLRchr1574468295+1151233251553100
ENST00000293288BAXchr1949459090+ENST00000395118ISLRchr1574468295+1151233251553100

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000539787ENST00000249842BAXchr1949459090+ISLRchr1574468295+0.092317920.90768206
ENST00000539787ENST00000395118BAXchr1949459090+ISLRchr1574468295+0.092317920.90768206
ENST00000345358ENST00000249842BAXchr1949459090+ISLRchr1574468295+0.214302480.7856975
ENST00000345358ENST00000395118BAXchr1949459090+ISLRchr1574468295+0.214302480.7856975
ENST00000415969ENST00000249842BAXchr1949459090+ISLRchr1574468295+0.170456050.82954395
ENST00000415969ENST00000395118BAXchr1949459090+ISLRchr1574468295+0.170456050.82954395
ENST00000293288ENST00000249842BAXchr1949459090+ISLRchr1574468295+0.170456050.82954395
ENST00000293288ENST00000395118BAXchr1949459090+ISLRchr1574468295+0.170456050.82954395

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Fusion Genomic Features for BAX-ISLR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for BAX-ISLR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:49459090/chr15:74468295)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBAXchr19:49459090chr15:74468295ENST00000293288+3559_7377219.0MotifNote=BH3
HgeneBAXchr19:49459090chr15:74468295ENST00000345358+3659_7377193.0MotifNote=BH3
HgeneBAXchr19:49459090chr15:74468295ENST00000415969+3659_7377180.0MotifNote=BH3
HgeneBAXchr19:49459090chr15:74468295ENST00000539787+3759_7377205.66666666666666MotifNote=BH3
TgeneISLRchr19:49459090chr15:74468295ENST0000024984202180_2310429.0DomainNote=LRRCT
TgeneISLRchr19:49459090chr15:74468295ENST000002498420219_500429.0DomainNote=LRRNT
TgeneISLRchr19:49459090chr15:74468295ENST0000024984202232_3430429.0DomainNote=Ig-like
TgeneISLRchr19:49459090chr15:74468295ENST0000039511802180_2310429.0DomainNote=LRRCT
TgeneISLRchr19:49459090chr15:74468295ENST000003951180219_500429.0DomainNote=LRRNT
TgeneISLRchr19:49459090chr15:74468295ENST0000039511802232_3430429.0DomainNote=Ig-like
TgeneISLRchr19:49459090chr15:74468295ENST0000024984202123_1440429.0RepeatNote=LRR 4
TgeneISLRchr19:49459090chr15:74468295ENST0000024984202147_1680429.0RepeatNote=LRR 5
TgeneISLRchr19:49459090chr15:74468295ENST000002498420251_720429.0RepeatNote=LRR 1
TgeneISLRchr19:49459090chr15:74468295ENST000002498420275_960429.0RepeatNote=LRR 2
TgeneISLRchr19:49459090chr15:74468295ENST000002498420299_1220429.0RepeatNote=LRR 3
TgeneISLRchr19:49459090chr15:74468295ENST0000039511802123_1440429.0RepeatNote=LRR 4
TgeneISLRchr19:49459090chr15:74468295ENST0000039511802147_1680429.0RepeatNote=LRR 5
TgeneISLRchr19:49459090chr15:74468295ENST000003951180251_720429.0RepeatNote=LRR 1
TgeneISLRchr19:49459090chr15:74468295ENST000003951180275_960429.0RepeatNote=LRR 2
TgeneISLRchr19:49459090chr15:74468295ENST000003951180299_1220429.0RepeatNote=LRR 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBAXchr19:49459090chr15:74468295ENST00000293288+35150_16577219.0MotifNote=BH2
HgeneBAXchr19:49459090chr15:74468295ENST00000293288+3598_11877219.0MotifNote=BH1
HgeneBAXchr19:49459090chr15:74468295ENST00000345358+36150_16577193.0MotifNote=BH2
HgeneBAXchr19:49459090chr15:74468295ENST00000345358+3698_11877193.0MotifNote=BH1
HgeneBAXchr19:49459090chr15:74468295ENST00000354470+15150_1650144.0MotifNote=BH2
HgeneBAXchr19:49459090chr15:74468295ENST00000354470+1559_730144.0MotifNote=BH3
HgeneBAXchr19:49459090chr15:74468295ENST00000354470+1598_1180144.0MotifNote=BH1
HgeneBAXchr19:49459090chr15:74468295ENST00000391871+25150_1656088.33333333333333MotifNote=BH2
HgeneBAXchr19:49459090chr15:74468295ENST00000391871+2559_736088.33333333333333MotifNote=BH3
HgeneBAXchr19:49459090chr15:74468295ENST00000391871+2598_1186088.33333333333333MotifNote=BH1
HgeneBAXchr19:49459090chr15:74468295ENST00000415969+36150_16577180.0MotifNote=BH2
HgeneBAXchr19:49459090chr15:74468295ENST00000415969+3698_11877180.0MotifNote=BH1
HgeneBAXchr19:49459090chr15:74468295ENST00000539787+37150_16577205.66666666666666MotifNote=BH2
HgeneBAXchr19:49459090chr15:74468295ENST00000539787+3798_11877205.66666666666666MotifNote=BH1
HgeneBAXchr19:49459090chr15:74468295ENST00000293288+35172_19277219.0TransmembraneHelical
HgeneBAXchr19:49459090chr15:74468295ENST00000345358+36172_19277193.0TransmembraneHelical
HgeneBAXchr19:49459090chr15:74468295ENST00000354470+15172_1920144.0TransmembraneHelical
HgeneBAXchr19:49459090chr15:74468295ENST00000391871+25172_1926088.33333333333333TransmembraneHelical
HgeneBAXchr19:49459090chr15:74468295ENST00000415969+36172_19277180.0TransmembraneHelical
HgeneBAXchr19:49459090chr15:74468295ENST00000539787+37172_19277205.66666666666666TransmembraneHelical


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Fusion Gene Sequence for BAX-ISLR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>9002_9002_1_BAX-ISLR_BAX_chr19_49459090_ENST00000293288_ISLR_chr15_74468295_ENST00000249842_length(transcript)=1151nt_BP=233nt
ATGGACGGGTCCGGGGAGCAGCCCAGAGGCGGGGGGCCCACCAGCTCTGAGCAGATCATGAAGACAGGGGCCCTTTTGCTTCAGGGTTTC
ATCCAGGATCGAGCAGGGCGAATGGGGGGGGAGGCACCCGAGCTGGCCCTGGACCCGGTGCCTCAGGATGCGTCCACCAAGAAGCTGAGC
GAGTGTCTCAAGCGCATCGGGGACGAACTGGACAGTAACATGGAGCTGCAGAGGAAAGGGCTGCTATACGGTTGACAACGAGGTGCAGCC
ATCAGGGCCGGAGGACAATGTGGTCATCATCTACCTCAGCCGTGCTGGGAACCCTGAGGCTGCAGTCGCAGAAGGGGTCCCTGGGCAGCT
GCCCCCAGGCCTGCTCCTGCTGGGCCAAAGCCTCCTCCTCTTCTTCTTCCTCACCTCCTTCTAGCCCCACCCAGGGCTTCCCTAACTCCT
CCCCTTGCCCCTACCAATGCCCCTTTAAGTGCTGCAGGGGTCTGGGGTTGGCAACTCCTGAGGCCTGCATGGGTGACTTCACATTTTCCT
ACCTCTCCTTCTAATCTCTTCTAGAGCACCTGCTATCCCCAACTTCTAGACCTGCTCCAAACTAGTGACTAGGATAGAATTTGATCCCCT
AACTCACTGTCTGCGGTGCTCATTGCTGCTAACAGCATTGCCTGTGCTCTCCTCTCAGGGGCAGCATGCTAACGGGGCGACGTCCTAATC
CAACTGGGAGAAGCCTCAGTGGTGGAATTCCAGGCACTGTGACTGTCAAGCTGGCAAGGGCCAGGATTGGGGGAATGGAGCTGGGGCTTA
GCTGGGAGGTGGTCTGAAGCAGACAGGGAATGGGAGAGGAGGATGGGAAGTAGACAGTGGCTGGTATGGCTCTGAGGCTCCCTGGGGCCT
GCTCAAGCTCCTCCTGCTCCTTGCTGTTTTCTGATGATTTGGGGGCTTGGGAGTCCCTTTGTCCTCATCTGAGACTGAAATGTGGGGATC
CAGGATGGCCTTCCTTCCTCTTACCCTTCCTCCCTCAGCCTGCAACCTCTATCCTGGAACCTGTCCTCCCTTTCTCCCCAACTATGCATC

>9002_9002_1_BAX-ISLR_BAX_chr19_49459090_ENST00000293288_ISLR_chr15_74468295_ENST00000249842_length(amino acids)=100AA_BP=
MTTRCSHQGRRTMWSSSTSAVLGTLRLQSQKGSLGSCPQACSCWAKASSSSSSSPPSSPTQGFPNSSPCPYQCPFKCCRGLGLATPEACM

--------------------------------------------------------------
>9002_9002_2_BAX-ISLR_BAX_chr19_49459090_ENST00000293288_ISLR_chr15_74468295_ENST00000395118_length(transcript)=1151nt_BP=233nt
ATGGACGGGTCCGGGGAGCAGCCCAGAGGCGGGGGGCCCACCAGCTCTGAGCAGATCATGAAGACAGGGGCCCTTTTGCTTCAGGGTTTC
ATCCAGGATCGAGCAGGGCGAATGGGGGGGGAGGCACCCGAGCTGGCCCTGGACCCGGTGCCTCAGGATGCGTCCACCAAGAAGCTGAGC
GAGTGTCTCAAGCGCATCGGGGACGAACTGGACAGTAACATGGAGCTGCAGAGGAAAGGGCTGCTATACGGTTGACAACGAGGTGCAGCC
ATCAGGGCCGGAGGACAATGTGGTCATCATCTACCTCAGCCGTGCTGGGAACCCTGAGGCTGCAGTCGCAGAAGGGGTCCCTGGGCAGCT
GCCCCCAGGCCTGCTCCTGCTGGGCCAAAGCCTCCTCCTCTTCTTCTTCCTCACCTCCTTCTAGCCCCACCCAGGGCTTCCCTAACTCCT
CCCCTTGCCCCTACCAATGCCCCTTTAAGTGCTGCAGGGGTCTGGGGTTGGCAACTCCTGAGGCCTGCATGGGTGACTTCACATTTTCCT
ACCTCTCCTTCTAATCTCTTCTAGAGCACCTGCTATCCCCAACTTCTAGACCTGCTCCAAACTAGTGACTAGGATAGAATTTGATCCCCT
AACTCACTGTCTGCGGTGCTCATTGCTGCTAACAGCATTGCCTGTGCTCTCCTCTCAGGGGCAGCATGCTAACGGGGCGACGTCCTAATC
CAACTGGGAGAAGCCTCAGTGGTGGAATTCCAGGCACTGTGACTGTCAAGCTGGCAAGGGCCAGGATTGGGGGAATGGAGCTGGGGCTTA
GCTGGGAGGTGGTCTGAAGCAGACAGGGAATGGGAGAGGAGGATGGGAAGTAGACAGTGGCTGGTATGGCTCTGAGGCTCCCTGGGGCCT
GCTCAAGCTCCTCCTGCTCCTTGCTGTTTTCTGATGATTTGGGGGCTTGGGAGTCCCTTTGTCCTCATCTGAGACTGAAATGTGGGGATC
CAGGATGGCCTTCCTTCCTCTTACCCTTCCTCCCTCAGCCTGCAACCTCTATCCTGGAACCTGTCCTCCCTTTCTCCCCAACTATGCATC

>9002_9002_2_BAX-ISLR_BAX_chr19_49459090_ENST00000293288_ISLR_chr15_74468295_ENST00000395118_length(amino acids)=100AA_BP=
MTTRCSHQGRRTMWSSSTSAVLGTLRLQSQKGSLGSCPQACSCWAKASSSSSSSPPSSPTQGFPNSSPCPYQCPFKCCRGLGLATPEACM

--------------------------------------------------------------
>9002_9002_3_BAX-ISLR_BAX_chr19_49459090_ENST00000345358_ISLR_chr15_74468295_ENST00000249842_length(transcript)=1203nt_BP=285nt
GCTGCGGCCGCCCGCGCGGACCCGGCGAGAGGCGGCGGCGGGAGCGGCGGTGATGGACGGGTCCGGGGAGCAGCCCAGAGGCGGGGGGCC
CACCAGCTCTGAGCAGATCATGAAGACAGGGGCCCTTTTGCTTCAGGGTTTCATCCAGGATCGAGCAGGGCGAATGGGGGGGGAGGCACC
CGAGCTGGCCCTGGACCCGGTGCCTCAGGATGCGTCCACCAAGAAGCTGAGCGAGTGTCTCAAGCGCATCGGGGACGAACTGGACAGTAA
CATGGAGCTGCAGAGGAAAGGGCTGCTATACGGTTGACAACGAGGTGCAGCCATCAGGGCCGGAGGACAATGTGGTCATCATCTACCTCA
GCCGTGCTGGGAACCCTGAGGCTGCAGTCGCAGAAGGGGTCCCTGGGCAGCTGCCCCCAGGCCTGCTCCTGCTGGGCCAAAGCCTCCTCC
TCTTCTTCTTCCTCACCTCCTTCTAGCCCCACCCAGGGCTTCCCTAACTCCTCCCCTTGCCCCTACCAATGCCCCTTTAAGTGCTGCAGG
GGTCTGGGGTTGGCAACTCCTGAGGCCTGCATGGGTGACTTCACATTTTCCTACCTCTCCTTCTAATCTCTTCTAGAGCACCTGCTATCC
CCAACTTCTAGACCTGCTCCAAACTAGTGACTAGGATAGAATTTGATCCCCTAACTCACTGTCTGCGGTGCTCATTGCTGCTAACAGCAT
TGCCTGTGCTCTCCTCTCAGGGGCAGCATGCTAACGGGGCGACGTCCTAATCCAACTGGGAGAAGCCTCAGTGGTGGAATTCCAGGCACT
GTGACTGTCAAGCTGGCAAGGGCCAGGATTGGGGGAATGGAGCTGGGGCTTAGCTGGGAGGTGGTCTGAAGCAGACAGGGAATGGGAGAG
GAGGATGGGAAGTAGACAGTGGCTGGTATGGCTCTGAGGCTCCCTGGGGCCTGCTCAAGCTCCTCCTGCTCCTTGCTGTTTTCTGATGAT
TTGGGGGCTTGGGAGTCCCTTTGTCCTCATCTGAGACTGAAATGTGGGGATCCAGGATGGCCTTCCTTCCTCTTACCCTTCCTCCCTCAG
CCTGCAACCTCTATCCTGGAACCTGTCCTCCCTTTCTCCCCAACTATGCATCTGTTGTCTGCTCCTCTGCAAAGGCCAGCCAGCTTGGGA

>9002_9002_3_BAX-ISLR_BAX_chr19_49459090_ENST00000345358_ISLR_chr15_74468295_ENST00000249842_length(amino acids)=101AA_BP=
LRPPARTRREAAAGAAVMDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLSECLKRIGDELDSN

--------------------------------------------------------------
>9002_9002_4_BAX-ISLR_BAX_chr19_49459090_ENST00000345358_ISLR_chr15_74468295_ENST00000395118_length(transcript)=1203nt_BP=285nt
GCTGCGGCCGCCCGCGCGGACCCGGCGAGAGGCGGCGGCGGGAGCGGCGGTGATGGACGGGTCCGGGGAGCAGCCCAGAGGCGGGGGGCC
CACCAGCTCTGAGCAGATCATGAAGACAGGGGCCCTTTTGCTTCAGGGTTTCATCCAGGATCGAGCAGGGCGAATGGGGGGGGAGGCACC
CGAGCTGGCCCTGGACCCGGTGCCTCAGGATGCGTCCACCAAGAAGCTGAGCGAGTGTCTCAAGCGCATCGGGGACGAACTGGACAGTAA
CATGGAGCTGCAGAGGAAAGGGCTGCTATACGGTTGACAACGAGGTGCAGCCATCAGGGCCGGAGGACAATGTGGTCATCATCTACCTCA
GCCGTGCTGGGAACCCTGAGGCTGCAGTCGCAGAAGGGGTCCCTGGGCAGCTGCCCCCAGGCCTGCTCCTGCTGGGCCAAAGCCTCCTCC
TCTTCTTCTTCCTCACCTCCTTCTAGCCCCACCCAGGGCTTCCCTAACTCCTCCCCTTGCCCCTACCAATGCCCCTTTAAGTGCTGCAGG
GGTCTGGGGTTGGCAACTCCTGAGGCCTGCATGGGTGACTTCACATTTTCCTACCTCTCCTTCTAATCTCTTCTAGAGCACCTGCTATCC
CCAACTTCTAGACCTGCTCCAAACTAGTGACTAGGATAGAATTTGATCCCCTAACTCACTGTCTGCGGTGCTCATTGCTGCTAACAGCAT
TGCCTGTGCTCTCCTCTCAGGGGCAGCATGCTAACGGGGCGACGTCCTAATCCAACTGGGAGAAGCCTCAGTGGTGGAATTCCAGGCACT
GTGACTGTCAAGCTGGCAAGGGCCAGGATTGGGGGAATGGAGCTGGGGCTTAGCTGGGAGGTGGTCTGAAGCAGACAGGGAATGGGAGAG
GAGGATGGGAAGTAGACAGTGGCTGGTATGGCTCTGAGGCTCCCTGGGGCCTGCTCAAGCTCCTCCTGCTCCTTGCTGTTTTCTGATGAT
TTGGGGGCTTGGGAGTCCCTTTGTCCTCATCTGAGACTGAAATGTGGGGATCCAGGATGGCCTTCCTTCCTCTTACCCTTCCTCCCTCAG
CCTGCAACCTCTATCCTGGAACCTGTCCTCCCTTTCTCCCCAACTATGCATCTGTTGTCTGCTCCTCTGCAAAGGCCAGCCAGCTTGGGA

>9002_9002_4_BAX-ISLR_BAX_chr19_49459090_ENST00000345358_ISLR_chr15_74468295_ENST00000395118_length(amino acids)=101AA_BP=
LRPPARTRREAAAGAAVMDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLSECLKRIGDELDSN

--------------------------------------------------------------
>9002_9002_5_BAX-ISLR_BAX_chr19_49459090_ENST00000415969_ISLR_chr15_74468295_ENST00000249842_length(transcript)=1151nt_BP=233nt
ATGGACGGGTCCGGGGAGCAGCCCAGAGGCGGGGGGCCCACCAGCTCTGAGCAGATCATGAAGACAGGGGCCCTTTTGCTTCAGGGTTTC
ATCCAGGATCGAGCAGGGCGAATGGGGGGGGAGGCACCCGAGCTGGCCCTGGACCCGGTGCCTCAGGATGCGTCCACCAAGAAGCTGAGC
GAGTGTCTCAAGCGCATCGGGGACGAACTGGACAGTAACATGGAGCTGCAGAGGAAAGGGCTGCTATACGGTTGACAACGAGGTGCAGCC
ATCAGGGCCGGAGGACAATGTGGTCATCATCTACCTCAGCCGTGCTGGGAACCCTGAGGCTGCAGTCGCAGAAGGGGTCCCTGGGCAGCT
GCCCCCAGGCCTGCTCCTGCTGGGCCAAAGCCTCCTCCTCTTCTTCTTCCTCACCTCCTTCTAGCCCCACCCAGGGCTTCCCTAACTCCT
CCCCTTGCCCCTACCAATGCCCCTTTAAGTGCTGCAGGGGTCTGGGGTTGGCAACTCCTGAGGCCTGCATGGGTGACTTCACATTTTCCT
ACCTCTCCTTCTAATCTCTTCTAGAGCACCTGCTATCCCCAACTTCTAGACCTGCTCCAAACTAGTGACTAGGATAGAATTTGATCCCCT
AACTCACTGTCTGCGGTGCTCATTGCTGCTAACAGCATTGCCTGTGCTCTCCTCTCAGGGGCAGCATGCTAACGGGGCGACGTCCTAATC
CAACTGGGAGAAGCCTCAGTGGTGGAATTCCAGGCACTGTGACTGTCAAGCTGGCAAGGGCCAGGATTGGGGGAATGGAGCTGGGGCTTA
GCTGGGAGGTGGTCTGAAGCAGACAGGGAATGGGAGAGGAGGATGGGAAGTAGACAGTGGCTGGTATGGCTCTGAGGCTCCCTGGGGCCT
GCTCAAGCTCCTCCTGCTCCTTGCTGTTTTCTGATGATTTGGGGGCTTGGGAGTCCCTTTGTCCTCATCTGAGACTGAAATGTGGGGATC
CAGGATGGCCTTCCTTCCTCTTACCCTTCCTCCCTCAGCCTGCAACCTCTATCCTGGAACCTGTCCTCCCTTTCTCCCCAACTATGCATC

>9002_9002_5_BAX-ISLR_BAX_chr19_49459090_ENST00000415969_ISLR_chr15_74468295_ENST00000249842_length(amino acids)=100AA_BP=
MTTRCSHQGRRTMWSSSTSAVLGTLRLQSQKGSLGSCPQACSCWAKASSSSSSSPPSSPTQGFPNSSPCPYQCPFKCCRGLGLATPEACM

--------------------------------------------------------------
>9002_9002_6_BAX-ISLR_BAX_chr19_49459090_ENST00000415969_ISLR_chr15_74468295_ENST00000395118_length(transcript)=1151nt_BP=233nt
ATGGACGGGTCCGGGGAGCAGCCCAGAGGCGGGGGGCCCACCAGCTCTGAGCAGATCATGAAGACAGGGGCCCTTTTGCTTCAGGGTTTC
ATCCAGGATCGAGCAGGGCGAATGGGGGGGGAGGCACCCGAGCTGGCCCTGGACCCGGTGCCTCAGGATGCGTCCACCAAGAAGCTGAGC
GAGTGTCTCAAGCGCATCGGGGACGAACTGGACAGTAACATGGAGCTGCAGAGGAAAGGGCTGCTATACGGTTGACAACGAGGTGCAGCC
ATCAGGGCCGGAGGACAATGTGGTCATCATCTACCTCAGCCGTGCTGGGAACCCTGAGGCTGCAGTCGCAGAAGGGGTCCCTGGGCAGCT
GCCCCCAGGCCTGCTCCTGCTGGGCCAAAGCCTCCTCCTCTTCTTCTTCCTCACCTCCTTCTAGCCCCACCCAGGGCTTCCCTAACTCCT
CCCCTTGCCCCTACCAATGCCCCTTTAAGTGCTGCAGGGGTCTGGGGTTGGCAACTCCTGAGGCCTGCATGGGTGACTTCACATTTTCCT
ACCTCTCCTTCTAATCTCTTCTAGAGCACCTGCTATCCCCAACTTCTAGACCTGCTCCAAACTAGTGACTAGGATAGAATTTGATCCCCT
AACTCACTGTCTGCGGTGCTCATTGCTGCTAACAGCATTGCCTGTGCTCTCCTCTCAGGGGCAGCATGCTAACGGGGCGACGTCCTAATC
CAACTGGGAGAAGCCTCAGTGGTGGAATTCCAGGCACTGTGACTGTCAAGCTGGCAAGGGCCAGGATTGGGGGAATGGAGCTGGGGCTTA
GCTGGGAGGTGGTCTGAAGCAGACAGGGAATGGGAGAGGAGGATGGGAAGTAGACAGTGGCTGGTATGGCTCTGAGGCTCCCTGGGGCCT
GCTCAAGCTCCTCCTGCTCCTTGCTGTTTTCTGATGATTTGGGGGCTTGGGAGTCCCTTTGTCCTCATCTGAGACTGAAATGTGGGGATC
CAGGATGGCCTTCCTTCCTCTTACCCTTCCTCCCTCAGCCTGCAACCTCTATCCTGGAACCTGTCCTCCCTTTCTCCCCAACTATGCATC

>9002_9002_6_BAX-ISLR_BAX_chr19_49459090_ENST00000415969_ISLR_chr15_74468295_ENST00000395118_length(amino acids)=100AA_BP=
MTTRCSHQGRRTMWSSSTSAVLGTLRLQSQKGSLGSCPQACSCWAKASSSSSSSPPSSPTQGFPNSSPCPYQCPFKCCRGLGLATPEACM

--------------------------------------------------------------
>9002_9002_7_BAX-ISLR_BAX_chr19_49459090_ENST00000539787_ISLR_chr15_74468295_ENST00000249842_length(transcript)=1220nt_BP=302nt
TCACGTGACCCGGGCGCGCTGCGGCCGCCCGCGCGGACCCGGCGAGAGGCGGCGGCGGGAGCGGCGGTGATGGACGGGTCCGGGGAGCAG
CCCAGAGGCGGGGGGCCCACCAGCTCTGAGCAGATCATGAAGACAGGGGCCCTTTTGCTTCAGGGTTTCATCCAGGATCGAGCAGGGCGA
ATGGGGGGGGAGGCACCCGAGCTGGCCCTGGACCCGGTGCCTCAGGATGCGTCCACCAAGAAGCTGAGCGAGTGTCTCAAGCGCATCGGG
GACGAACTGGACAGTAACATGGAGCTGCAGAGGAAAGGGCTGCTATACGGTTGACAACGAGGTGCAGCCATCAGGGCCGGAGGACAATGT
GGTCATCATCTACCTCAGCCGTGCTGGGAACCCTGAGGCTGCAGTCGCAGAAGGGGTCCCTGGGCAGCTGCCCCCAGGCCTGCTCCTGCT
GGGCCAAAGCCTCCTCCTCTTCTTCTTCCTCACCTCCTTCTAGCCCCACCCAGGGCTTCCCTAACTCCTCCCCTTGCCCCTACCAATGCC
CCTTTAAGTGCTGCAGGGGTCTGGGGTTGGCAACTCCTGAGGCCTGCATGGGTGACTTCACATTTTCCTACCTCTCCTTCTAATCTCTTC
TAGAGCACCTGCTATCCCCAACTTCTAGACCTGCTCCAAACTAGTGACTAGGATAGAATTTGATCCCCTAACTCACTGTCTGCGGTGCTC
ATTGCTGCTAACAGCATTGCCTGTGCTCTCCTCTCAGGGGCAGCATGCTAACGGGGCGACGTCCTAATCCAACTGGGAGAAGCCTCAGTG
GTGGAATTCCAGGCACTGTGACTGTCAAGCTGGCAAGGGCCAGGATTGGGGGAATGGAGCTGGGGCTTAGCTGGGAGGTGGTCTGAAGCA
GACAGGGAATGGGAGAGGAGGATGGGAAGTAGACAGTGGCTGGTATGGCTCTGAGGCTCCCTGGGGCCTGCTCAAGCTCCTCCTGCTCCT
TGCTGTTTTCTGATGATTTGGGGGCTTGGGAGTCCCTTTGTCCTCATCTGAGACTGAAATGTGGGGATCCAGGATGGCCTTCCTTCCTCT
TACCCTTCCTCCCTCAGCCTGCAACCTCTATCCTGGAACCTGTCCTCCCTTTCTCCCCAACTATGCATCTGTTGTCTGCTCCTCTGCAAA

>9002_9002_7_BAX-ISLR_BAX_chr19_49459090_ENST00000539787_ISLR_chr15_74468295_ENST00000249842_length(amino acids)=101AA_BP=
MRPPARTRREAAAGAAVMDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLSECLKRIGDELDSN

--------------------------------------------------------------
>9002_9002_8_BAX-ISLR_BAX_chr19_49459090_ENST00000539787_ISLR_chr15_74468295_ENST00000395118_length(transcript)=1220nt_BP=302nt
TCACGTGACCCGGGCGCGCTGCGGCCGCCCGCGCGGACCCGGCGAGAGGCGGCGGCGGGAGCGGCGGTGATGGACGGGTCCGGGGAGCAG
CCCAGAGGCGGGGGGCCCACCAGCTCTGAGCAGATCATGAAGACAGGGGCCCTTTTGCTTCAGGGTTTCATCCAGGATCGAGCAGGGCGA
ATGGGGGGGGAGGCACCCGAGCTGGCCCTGGACCCGGTGCCTCAGGATGCGTCCACCAAGAAGCTGAGCGAGTGTCTCAAGCGCATCGGG
GACGAACTGGACAGTAACATGGAGCTGCAGAGGAAAGGGCTGCTATACGGTTGACAACGAGGTGCAGCCATCAGGGCCGGAGGACAATGT
GGTCATCATCTACCTCAGCCGTGCTGGGAACCCTGAGGCTGCAGTCGCAGAAGGGGTCCCTGGGCAGCTGCCCCCAGGCCTGCTCCTGCT
GGGCCAAAGCCTCCTCCTCTTCTTCTTCCTCACCTCCTTCTAGCCCCACCCAGGGCTTCCCTAACTCCTCCCCTTGCCCCTACCAATGCC
CCTTTAAGTGCTGCAGGGGTCTGGGGTTGGCAACTCCTGAGGCCTGCATGGGTGACTTCACATTTTCCTACCTCTCCTTCTAATCTCTTC
TAGAGCACCTGCTATCCCCAACTTCTAGACCTGCTCCAAACTAGTGACTAGGATAGAATTTGATCCCCTAACTCACTGTCTGCGGTGCTC
ATTGCTGCTAACAGCATTGCCTGTGCTCTCCTCTCAGGGGCAGCATGCTAACGGGGCGACGTCCTAATCCAACTGGGAGAAGCCTCAGTG
GTGGAATTCCAGGCACTGTGACTGTCAAGCTGGCAAGGGCCAGGATTGGGGGAATGGAGCTGGGGCTTAGCTGGGAGGTGGTCTGAAGCA
GACAGGGAATGGGAGAGGAGGATGGGAAGTAGACAGTGGCTGGTATGGCTCTGAGGCTCCCTGGGGCCTGCTCAAGCTCCTCCTGCTCCT
TGCTGTTTTCTGATGATTTGGGGGCTTGGGAGTCCCTTTGTCCTCATCTGAGACTGAAATGTGGGGATCCAGGATGGCCTTCCTTCCTCT
TACCCTTCCTCCCTCAGCCTGCAACCTCTATCCTGGAACCTGTCCTCCCTTTCTCCCCAACTATGCATCTGTTGTCTGCTCCTCTGCAAA

>9002_9002_8_BAX-ISLR_BAX_chr19_49459090_ENST00000539787_ISLR_chr15_74468295_ENST00000395118_length(amino acids)=101AA_BP=
MRPPARTRREAAAGAAVMDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLSECLKRIGDELDSN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for BAX-ISLR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BAX-ISLR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BAX-ISLR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBAXC0027051Myocardial Infarction2CTD_human
HgeneBAXC0002152Alloxan Diabetes1CTD_human
HgeneBAXC0002395Alzheimer's Disease1CTD_human
HgeneBAXC0006142Malignant neoplasm of breast1CTD_human
HgeneBAXC0007102Malignant tumor of colon1CTD_human
HgeneBAXC0009375Colonic Neoplasms1CTD_human
HgeneBAXC0011265Presenile dementia1CTD_human
HgeneBAXC0011853Diabetes Mellitus, Experimental1CTD_human
HgeneBAXC0014859Esophageal Neoplasms1CTD_human
HgeneBAXC0019193Hepatitis, Toxic1CTD_human
HgeneBAXC0019693HIV Infections1CTD_human
HgeneBAXC0021364Male infertility1CTD_human
HgeneBAXC0021841Intestinal Neoplasms1CTD_human
HgeneBAXC0022116Ischemia1CTD_human
HgeneBAXC0022660Kidney Failure, Acute1CTD_human
HgeneBAXC0027055Myocardial Reperfusion Injury1CTD_human
HgeneBAXC0027746Nerve Degeneration1CTD_human
HgeneBAXC0032460Polycystic Ovary Syndrome1CTD_human
HgeneBAXC0033578Prostatic Neoplasms1CTD_human
HgeneBAXC0038433Streptozotocin Diabetes1CTD_human
HgeneBAXC0079773Lymphoma, T-Cell, Cutaneous1CTD_human
HgeneBAXC0276496Familial Alzheimer Disease (FAD)1CTD_human
HgeneBAXC0346627Intestinal Cancer1CTD_human
HgeneBAXC0376358Malignant neoplasm of prostate1CTD_human
HgeneBAXC0376407Granulomatous Slack Skin1CTD_human
HgeneBAXC0494463Alzheimer Disease, Late Onset1CTD_human
HgeneBAXC0546126Acute Confusional Senile Dementia1CTD_human
HgeneBAXC0546837Malignant neoplasm of esophagus1CTD_human
HgeneBAXC0678222Breast Carcinoma1CTD_human
HgeneBAXC0750900Alzheimer's Disease, Focal Onset1CTD_human
HgeneBAXC0750901Alzheimer Disease, Early Onset1CTD_human
HgeneBAXC0848676Subfertility, Male1CTD_human
HgeneBAXC0860207Drug-Induced Liver Disease1CTD_human
HgeneBAXC0917731Male sterility1CTD_human
HgeneBAXC0920269Microsatellite Instability1CTD_human
HgeneBAXC1136382Sclerocystic Ovaries1CTD_human
HgeneBAXC1257931Mammary Neoplasms, Human1CTD_human
HgeneBAXC1262760Hepatitis, Drug-Induced1CTD_human
HgeneBAXC1458155Mammary Neoplasms1CTD_human
HgeneBAXC1565662Acute Kidney Insufficiency1CTD_human
HgeneBAXC1721098Replication Error Phenotype1CTD_human
HgeneBAXC2609414Acute kidney injury1CTD_human
HgeneBAXC2937358Cerebral Hemorrhage1CTD_human
HgeneBAXC3658290Drug-Induced Acute Liver Injury1CTD_human
HgeneBAXC4277682Chemical and Drug Induced Liver Injury1CTD_human
HgeneBAXC4279912Chemically-Induced Liver Toxicity1CTD_human
HgeneBAXC4505456HIV Coinfection1CTD_human
HgeneBAXC4704874Mammary Carcinoma, Human1CTD_human