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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FAM108C1-BHLHE41 (FusionGDB2 ID:HG58489TG79365)

Fusion Gene Summary for FAM108C1-BHLHE41

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM108C1-BHLHE41
Fusion gene ID: hg58489tg79365
HgeneTgene
Gene symbol

FAM108C1

BHLHE41

Gene ID

58489

79365

Gene nameabhydrolase domain containing 17C, depalmitoylasebasic helix-loop-helix family member e41
SynonymsFAM108C1BHLHB3|DEC2|FNSS1|SHARP1|hDEC2
Cytomap('ABHD17C','FAM108C1')('BHLHE41','BHLHE41')

15q25.1

12p12.1

Type of geneprotein-codingprotein-coding
Descriptionalpha/beta hydrolase domain-containing protein 17Cabhydrolase domain containing 17Cabhydrolase domain-containing protein 17Cabhydrolase domain-containing protein FAM108C1family with sequence similarity 108, member C1protein ABHD17Cclass E basic helix-loop-helix protein 41basic helix-loop-helix domain containing, class B, 3differentially expressed in chondrocytes protein 2enhancer-of-split and hairy-related protein 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000258884, ENST00000558464, 
ENST00000559506, ENST00000560609, 
Fusion gene scores* DoF score4 X 3 X 4=485 X 2 X 4=40
# samples 45
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FAM108C1 [Title/Abstract] AND BHLHE41 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointABHD17C(80988360)-BHLHE41(26277515), # samples:2
FAM108C1(80988360)-BHLHE41(26277515), # samples:1
Anticipated loss of major functional domain due to fusion event.ABHD17C-BHLHE41 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABHD17C-BHLHE41 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBHLHE41

GO:0000122

negative regulation of transcription by RNA polymerase II

14672706|15193144


check buttonFusion gene breakpoints across ABHD17C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across BHLHE41 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-D7-8575-01AABHD17Cchr15

80988360

+BHLHE41chr12

26277515

-
ChimerDB4STADTCGA-D7-8575FAM108C1chr15

80988360

+BHLHE41chr12

26277515

-


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Fusion Gene ORF analysis for FAM108C1-BHLHE41

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000258884ENST00000242728ABHD17Cchr15

80988360

+BHLHE41chr12

26277515

-
In-frameENST00000558464ENST00000242728ABHD17Cchr15

80988360

+BHLHE41chr12

26277515

-
intron-3CDSENST00000559506ENST00000242728ABHD17Cchr15

80988360

+BHLHE41chr12

26277515

-
intron-3CDSENST00000560609ENST00000242728ABHD17Cchr15

80988360

+BHLHE41chr12

26277515

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000258884ABHD17Cchr1580988360+ENST00000242728BHLHE41chr1226277515-4144717102103697
ENST00000558464ABHD17Cchr1580988360+ENST00000242728BHLHE41chr1226277515-413670922095697

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000258884ENST00000242728ABHD17Cchr1580988360+BHLHE41chr1226277515-0.0028521210.99714786
ENST00000558464ENST00000242728ABHD17Cchr1580988360+BHLHE41chr1226277515-0.0028792930.9971207

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Fusion Genomic Features for FAM108C1-BHLHE41


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for FAM108C1-BHLHE41


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:80988360/:26277515)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABHD17Cchr15:80988360chr12:26277515ENST00000258884+1352_86196330.0Compositional biasNote=Ala-rich
HgeneABHD17Cchr15:80988360chr12:26277515ENST00000558464+1352_86196296.0Compositional biasNote=Ala-rich
TgeneBHLHE41chr15:80988360chr12:26277515ENST0000024272805297_43120483.0Compositional biasNote=Ala/Gly-rich
TgeneBHLHE41chr15:80988360chr12:26277515ENST0000024272805131_16620483.0DomainOrange
TgeneBHLHE41chr15:80988360chr12:26277515ENST000002427280544_9920483.0DomainbHLH

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for FAM108C1-BHLHE41


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>407_407_1_ABHD17C-BHLHE41_ABHD17C_chr15_80988360_ENST00000258884_BHLHE41_chr12_26277515_ENST00000242728_length(transcript)=4144nt_BP=717nt
GGCGGGCGGGCTGCAGCCGCCCTCCGCGCTCGCCTGCCAGCTCCCTCGCCGCGCGTCCGTCCTCCGTCCTCCCGGGCCAGCCAGCCAGCC
AGCCAGCCGGGCCGGCGGCGGGCACCAGGCCGTCCCGATGCCCGAGCCAGGCCCCAGGATGAACGGCTTCTCGCTGGGTGAGCTGTGCTG
GCTCTTCTGCTGCCCGCCCTGCCCGAGCCGCATCGCCGCCAAGCTGGCCTTCCTGCCGCCCGAGCCCACCTACACGGTGCTGGCGCCGGA
GCAGCGCGGCGCCGGCGCGTCCGCCCCGGCCCCGGCCCAGGCTACCGCCGCCGCCGCCGCGGCCCAGCCGGCACCGCAGCAGCCCGAGGA
GGGCGCGGGCGCGGGGCCCGGTGCGTGCAGCCTGCACCTCAGCGAGCGCGCCGACTGGCAGTACTCGCAGCGCGAGCTGGACGCCGTCGA
GGTCTTCTTCTCGCGCACGGCCCGGGACAACCGGCTCGGCTGCATGTTCGTGCGCTGCGCGCCCTCCAGCCGCTACACGCTGCTCTTCTC
GCACGGCAACGCCGTGGACCTGGGCCAGATGTGCAGCTTCTACATTGGCCTCGGCTCCCGCATCAACTGCAACATCTTCTCCTACGACTA
CTCGGGATACGGCGTCAGCTCGGGCAAGCCCTCCGAGAAGAACCTCTACGCCGACATCGACGCCGCGTGGCAGGCGCTGCGCACCCGACT
GGACTATTCCTCTTTGTATATGTGTAAACCCAAAAGGAGCATGAAACGAGACGACACCAAGGATACCTACAAATTACCGCACAGATTAAT
AGAAAAGAAAAGAAGAGACCGAATTAATGAATGCATTGCTCAGCTGAAAGATTTACTGCCTGAACATCTGAAATTGACAACTCTGGGACA
TCTGGAGAAAGCTGTAGTCTTGGAATTAACTTTGAAACACTTAAAAGCTTTAACCGCCTTAACCGAGCAACAGCATCAGAAGATAATTGC
TTTACAGAATGGGGAGCGATCTCTGAAATCGCCCATTCAGTCCGACTTGGATGCGTTCCACTCGGGATTTCAAACATGCGCCAAAGAAGT
CTTGCAATACCTCTCCCGGTTTGAGAGCTGGACACCCAGGGAGCCGCGGTGTGTCCAGCTGATCAACCACTTGCACGCCGTGGCCACCCA
GTTCTTGCCCACCCCGCAGCTGTTGACTCAACAGGTCCCTCTGAGCAAAGGCACCGGCGCTCCCTCGGCCGCCGGGTCCGCGGCCGCCCC
CTGCCTGGAGCGCGCGGGGCAGAAGCTGGAGCCCCTCGCCTACTGCGTGCCCGTCATCCAGCGGACTCAGCCCAGCGCCGAGCTCGCCGC
CGAGAACGACACGGACACCGACAGCGGCTACGGCGGCGAAGCCGAGGCCCGGCCGGACCGCGAGAAAGGCAAAGGCGCGGGGGCGAGCCG
CGTCACCATCAAGCAGGAGCCTCCCGGGGAGGACTCGCCGGCGCCCAAGAGGATGAAGCTGGATTCCCGCGGCGGCGGCAGCGGCGGCGG
CCCGGGGGGCGGCGCGGCGGCGGCGGCAGCCGCGCTTCTGGGGCCCGACCCTGCCGCCGCGGCCGCGCTGCTGAGACCCGACGCCGCCCT
GCTCAGCTCGCTGGTGGCGTTCGGCGGAGGCGGAGGCGCGCCCTTCCCGCAGCCCGCGGCCGCCGCGGCCCCCTTCTGCCTGCCCTTCTG
CTTCCTCTCGCCTTCTGCAGCTGCCGCCTACGTGCAGCCCTTCCTGGACAAGAGCGGCCTGGAGAAGTATCTGTACCCGGCGGCGGCTGC
CGCCCCGTTCCCGCTGCTATACCCCGGCATCCCCGCCCCGGCGGCAGCCGCGGCAGCCGCCGCCGCCGCTGCCGCCGCCGCCGCCGCGTT
CCCCTGCCTGTCCTCGGTGTTGTCGCCCCCTCCCGAGAAGGCGGGCGCCGCCGCCGCGACCCTCCTGCCGCACGAGGTGGCGCCCCTTGG
GGCGCCGCACCCCCAGCACCCGCACGGCCGCACCCACCTGCCCTTCGCCGGGCCCCGCGAGCCGGGGAACCCGGAGAGCTCTGCTCAGGA
AGATCCCTCGCAGCCAGGAAAGGAAGCTCCCTGAATCCTTGCGTCCCGAAGGACGGAGGTTCAAGCAGAGTGAGAAGTTAAAATACCCTT
AAGGAGGTTCAAGCAGAGTGAGAAGTTAAAATACCCTTAAGGTCTTTAAGGGAGGAAGTGTAATAGATGCACGACAGGCATAAACAAGAA
CAACAAAACAGGTGTTATGTGTACATTCGGAGTTCCTGTTTTGCTCATCCCGCACCACCCCACCCTCCACACACTAACATCCCTTTCTTC
CCCCCACCAGCTGTAAAAGATCCTATGCGAAAGACACTGGCTCTTTTTTTTAATCCCCCAAATAAATTTTGCCCCCTTTTAGGCCATGTT
CCATTATCTCTTAAAATTGGAACCTAATTCGAGAGGAAGTAAGAAGGGTCTGTTCTGTGGCTGAGCTAGGTGAACCCCGGGGTAGGGGAA
AGATGTTAACACCTTTGACGTCTTTGGAGTTGACATGGAACAGCAGGTAGTTGTTATGTAGAGCTAGTTCTCAAAGCTGCCCTGCCTGTT
TTAGGAGGCGTTCCACAAACAGATTGAGGCTCTTTTAGAATTGAATTTACTCTTCAGTATTTTCTAATGTTCAGCTTTCTAAAAGGCATA
TATTTTTCAAAGAAGTGAGGATGCAGTTTCTCACGTTGCAACCTATTCTGAAGTGGTTTAAATGGTATCTCTTAGTAACTTGCACTCGTT
AAAGAAACACGGAGCTGGGCCATCGTCAGAACTAAGTCAGGGAAGGAGATGGATGAGAAGGCCAGAATCATTCCTAGTACATTTGCTAAC
ACTTTATTGAGAAATTGACCATGAATTAATGGACTCATCTTAATTTCTTCTAAGTCCATATATAGATAGATATCTATCTGTACAGATTTC
TATTTATCCATAGATAGGTATCTATACATACACATCTCAAGTGCATCTATTCCCACTCTCATTAATCCATCATGTTCCTAAATTTTTGTA
ATCTTACTGTAAAAAAAAGTGCACTGAACTTCAAAACAAAACAAAAAACAACAACAACAAAAAACAAGTCCAAACTGATATATCCTATAT
TCTGTTAAAATTCAAAAGTGAACGAAAGCATTTAACTGGCCAGTTTTGATTGCAAATGCTGTAAAGATATAGAATGAAGTCCTGTGAGGC
CTTCCTATCTCCAAGTCTATGTATTTTCTGGAGACCAAACCAGATACCAGATAATCACAAAGAAAGCTTTTTTAATAAGGCTTAAACCAA
GACCTTGTCTAGATATTTTTAGTTTGTTGCCAAGGTAGCACTGTGAGAAATCTCACTTGGATGTTATGTAAGGGGTGAGACACAACAGTC
TGACTATGAGTGAGGAAAATATCTGGGTCTTTTCGTCAGTTTGGTGCATTTGCTGCTGCTGTTGCTACTGTTTGCCTCAAACGCTGTGTT
TAAACAACGTTAAACTCTTAGCCTACAAGGTGGCTCTTATGTACATAGTTGTTAATACATCCAATTAATGATGTCTGACATGCTATTTTT
GTAGGGAGAAAATATGTGCTAATGATATTTTGAGTTAAAATATCTTTTGGGGAGGATTTGCTGAAAAGTTGCACTTTTGTTACAATGCTT
ATGCTTGGTACAAGCTTATGCTGTCTTAAATTATTTTAAAAAAATAAATACTGTCTGTGAGAAACCAGCTGGTTTAGAAAAGTTTAGTAT
GTGACGATAAACTAGAAATTACCTTTATATTCTAGTATTTTCAGCACTCCATAAATTCTATTACCTAAATATTGCCACACTATTTTGTGA
TTTAAAAATTCTTACTAAGGAATAAAAACTTTAATATACGATATGATATTGTCTAATAATTAAAAAAGACATAATGGATGCTCAATTAGT
TTTAAGATATCTATAACTATAGGGATACAAATCACTACAGTTCTCAGATTTACAGCTTTTTTTTGTCATTGGCTTGATGTCACACATTTC
CAATCTCTTGCAAGCCTCCAGGCTCTGGCTTTGTCTACCTGCTCGTTCCCAATGTATCTTAATGAAAAGTGCAAAAGAAAAACCTACCAA

>407_407_1_ABHD17C-BHLHE41_ABHD17C_chr15_80988360_ENST00000258884_BHLHE41_chr12_26277515_ENST00000242728_length(amino acids)=697AA_BP=235
MQPPSALACQLPRRASVLRPPGPASQPASRAGGGHQAVPMPEPGPRMNGFSLGELCWLFCCPPCPSRIAAKLAFLPPEPTYTVLAPEQRG
AGASAPAPAQATAAAAAAQPAPQQPEEGAGAGPGACSLHLSERADWQYSQRELDAVEVFFSRTARDNRLGCMFVRCAPSSRYTLLFSHGN
AVDLGQMCSFYIGLGSRINCNIFSYDYSGYGVSSGKPSEKNLYADIDAAWQALRTRLDYSSLYMCKPKRSMKRDDTKDTYKLPHRLIEKK
RRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHLKALTALTEQQHQKIIALQNGERSLKSPIQSDLDAFHSGFQTCAKEVLQY
LSRFESWTPREPRCVQLINHLHAVATQFLPTPQLLTQQVPLSKGTGAPSAAGSAAAPCLERAGQKLEPLAYCVPVIQRTQPSAELAAEND
TDTDSGYGGEAEARPDREKGKGAGASRVTIKQEPPGEDSPAPKRMKLDSRGGGSGGGPGGGAAAAAAALLGPDPAAAAALLRPDAALLSS
LVAFGGGGGAPFPQPAAAAAPFCLPFCFLSPSAAAAYVQPFLDKSGLEKYLYPAAAAAPFPLLYPGIPAPAAAAAAAAAAAAAAAAFPCL

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>407_407_2_ABHD17C-BHLHE41_ABHD17C_chr15_80988360_ENST00000558464_BHLHE41_chr12_26277515_ENST00000242728_length(transcript)=4136nt_BP=709nt
GGCTGCAGCCGCCCTCCGCGCTCGCCTGCCAGCTCCCTCGCCGCGCGTCCGTCCTCCGTCCTCCCGGGCCAGCCAGCCAGCCAGCCAGCC
GGGCCGGCGGCGGGCACCAGGCCGTCCCGATGCCCGAGCCAGGCCCCAGGATGAACGGCTTCTCGCTGGGTGAGCTGTGCTGGCTCTTCT
GCTGCCCGCCCTGCCCGAGCCGCATCGCCGCCAAGCTGGCCTTCCTGCCGCCCGAGCCCACCTACACGGTGCTGGCGCCGGAGCAGCGCG
GCGCCGGCGCGTCCGCCCCGGCCCCGGCCCAGGCTACCGCCGCCGCCGCCGCGGCCCAGCCGGCACCGCAGCAGCCCGAGGAGGGCGCGG
GCGCGGGGCCCGGTGCGTGCAGCCTGCACCTCAGCGAGCGCGCCGACTGGCAGTACTCGCAGCGCGAGCTGGACGCCGTCGAGGTCTTCT
TCTCGCGCACGGCCCGGGACAACCGGCTCGGCTGCATGTTCGTGCGCTGCGCGCCCTCCAGCCGCTACACGCTGCTCTTCTCGCACGGCA
ACGCCGTGGACCTGGGCCAGATGTGCAGCTTCTACATTGGCCTCGGCTCCCGCATCAACTGCAACATCTTCTCCTACGACTACTCGGGAT
ACGGCGTCAGCTCGGGCAAGCCCTCCGAGAAGAACCTCTACGCCGACATCGACGCCGCGTGGCAGGCGCTGCGCACCCGACTGGACTATT
CCTCTTTGTATATGTGTAAACCCAAAAGGAGCATGAAACGAGACGACACCAAGGATACCTACAAATTACCGCACAGATTAATAGAAAAGA
AAAGAAGAGACCGAATTAATGAATGCATTGCTCAGCTGAAAGATTTACTGCCTGAACATCTGAAATTGACAACTCTGGGACATCTGGAGA
AAGCTGTAGTCTTGGAATTAACTTTGAAACACTTAAAAGCTTTAACCGCCTTAACCGAGCAACAGCATCAGAAGATAATTGCTTTACAGA
ATGGGGAGCGATCTCTGAAATCGCCCATTCAGTCCGACTTGGATGCGTTCCACTCGGGATTTCAAACATGCGCCAAAGAAGTCTTGCAAT
ACCTCTCCCGGTTTGAGAGCTGGACACCCAGGGAGCCGCGGTGTGTCCAGCTGATCAACCACTTGCACGCCGTGGCCACCCAGTTCTTGC
CCACCCCGCAGCTGTTGACTCAACAGGTCCCTCTGAGCAAAGGCACCGGCGCTCCCTCGGCCGCCGGGTCCGCGGCCGCCCCCTGCCTGG
AGCGCGCGGGGCAGAAGCTGGAGCCCCTCGCCTACTGCGTGCCCGTCATCCAGCGGACTCAGCCCAGCGCCGAGCTCGCCGCCGAGAACG
ACACGGACACCGACAGCGGCTACGGCGGCGAAGCCGAGGCCCGGCCGGACCGCGAGAAAGGCAAAGGCGCGGGGGCGAGCCGCGTCACCA
TCAAGCAGGAGCCTCCCGGGGAGGACTCGCCGGCGCCCAAGAGGATGAAGCTGGATTCCCGCGGCGGCGGCAGCGGCGGCGGCCCGGGGG
GCGGCGCGGCGGCGGCGGCAGCCGCGCTTCTGGGGCCCGACCCTGCCGCCGCGGCCGCGCTGCTGAGACCCGACGCCGCCCTGCTCAGCT
CGCTGGTGGCGTTCGGCGGAGGCGGAGGCGCGCCCTTCCCGCAGCCCGCGGCCGCCGCGGCCCCCTTCTGCCTGCCCTTCTGCTTCCTCT
CGCCTTCTGCAGCTGCCGCCTACGTGCAGCCCTTCCTGGACAAGAGCGGCCTGGAGAAGTATCTGTACCCGGCGGCGGCTGCCGCCCCGT
TCCCGCTGCTATACCCCGGCATCCCCGCCCCGGCGGCAGCCGCGGCAGCCGCCGCCGCCGCTGCCGCCGCCGCCGCCGCGTTCCCCTGCC
TGTCCTCGGTGTTGTCGCCCCCTCCCGAGAAGGCGGGCGCCGCCGCCGCGACCCTCCTGCCGCACGAGGTGGCGCCCCTTGGGGCGCCGC
ACCCCCAGCACCCGCACGGCCGCACCCACCTGCCCTTCGCCGGGCCCCGCGAGCCGGGGAACCCGGAGAGCTCTGCTCAGGAAGATCCCT
CGCAGCCAGGAAAGGAAGCTCCCTGAATCCTTGCGTCCCGAAGGACGGAGGTTCAAGCAGAGTGAGAAGTTAAAATACCCTTAAGGAGGT
TCAAGCAGAGTGAGAAGTTAAAATACCCTTAAGGTCTTTAAGGGAGGAAGTGTAATAGATGCACGACAGGCATAAACAAGAACAACAAAA
CAGGTGTTATGTGTACATTCGGAGTTCCTGTTTTGCTCATCCCGCACCACCCCACCCTCCACACACTAACATCCCTTTCTTCCCCCCACC
AGCTGTAAAAGATCCTATGCGAAAGACACTGGCTCTTTTTTTTAATCCCCCAAATAAATTTTGCCCCCTTTTAGGCCATGTTCCATTATC
TCTTAAAATTGGAACCTAATTCGAGAGGAAGTAAGAAGGGTCTGTTCTGTGGCTGAGCTAGGTGAACCCCGGGGTAGGGGAAAGATGTTA
ACACCTTTGACGTCTTTGGAGTTGACATGGAACAGCAGGTAGTTGTTATGTAGAGCTAGTTCTCAAAGCTGCCCTGCCTGTTTTAGGAGG
CGTTCCACAAACAGATTGAGGCTCTTTTAGAATTGAATTTACTCTTCAGTATTTTCTAATGTTCAGCTTTCTAAAAGGCATATATTTTTC
AAAGAAGTGAGGATGCAGTTTCTCACGTTGCAACCTATTCTGAAGTGGTTTAAATGGTATCTCTTAGTAACTTGCACTCGTTAAAGAAAC
ACGGAGCTGGGCCATCGTCAGAACTAAGTCAGGGAAGGAGATGGATGAGAAGGCCAGAATCATTCCTAGTACATTTGCTAACACTTTATT
GAGAAATTGACCATGAATTAATGGACTCATCTTAATTTCTTCTAAGTCCATATATAGATAGATATCTATCTGTACAGATTTCTATTTATC
CATAGATAGGTATCTATACATACACATCTCAAGTGCATCTATTCCCACTCTCATTAATCCATCATGTTCCTAAATTTTTGTAATCTTACT
GTAAAAAAAAGTGCACTGAACTTCAAAACAAAACAAAAAACAACAACAACAAAAAACAAGTCCAAACTGATATATCCTATATTCTGTTAA
AATTCAAAAGTGAACGAAAGCATTTAACTGGCCAGTTTTGATTGCAAATGCTGTAAAGATATAGAATGAAGTCCTGTGAGGCCTTCCTAT
CTCCAAGTCTATGTATTTTCTGGAGACCAAACCAGATACCAGATAATCACAAAGAAAGCTTTTTTAATAAGGCTTAAACCAAGACCTTGT
CTAGATATTTTTAGTTTGTTGCCAAGGTAGCACTGTGAGAAATCTCACTTGGATGTTATGTAAGGGGTGAGACACAACAGTCTGACTATG
AGTGAGGAAAATATCTGGGTCTTTTCGTCAGTTTGGTGCATTTGCTGCTGCTGTTGCTACTGTTTGCCTCAAACGCTGTGTTTAAACAAC
GTTAAACTCTTAGCCTACAAGGTGGCTCTTATGTACATAGTTGTTAATACATCCAATTAATGATGTCTGACATGCTATTTTTGTAGGGAG
AAAATATGTGCTAATGATATTTTGAGTTAAAATATCTTTTGGGGAGGATTTGCTGAAAAGTTGCACTTTTGTTACAATGCTTATGCTTGG
TACAAGCTTATGCTGTCTTAAATTATTTTAAAAAAATAAATACTGTCTGTGAGAAACCAGCTGGTTTAGAAAAGTTTAGTATGTGACGAT
AAACTAGAAATTACCTTTATATTCTAGTATTTTCAGCACTCCATAAATTCTATTACCTAAATATTGCCACACTATTTTGTGATTTAAAAA
TTCTTACTAAGGAATAAAAACTTTAATATACGATATGATATTGTCTAATAATTAAAAAAGACATAATGGATGCTCAATTAGTTTTAAGAT
ATCTATAACTATAGGGATACAAATCACTACAGTTCTCAGATTTACAGCTTTTTTTTGTCATTGGCTTGATGTCACACATTTCCAATCTCT

>407_407_2_ABHD17C-BHLHE41_ABHD17C_chr15_80988360_ENST00000558464_BHLHE41_chr12_26277515_ENST00000242728_length(amino acids)=697AA_BP=235
LQPPSALACQLPRRASVLRPPGPASQPASRAGGGHQAVPMPEPGPRMNGFSLGELCWLFCCPPCPSRIAAKLAFLPPEPTYTVLAPEQRG
AGASAPAPAQATAAAAAAQPAPQQPEEGAGAGPGACSLHLSERADWQYSQRELDAVEVFFSRTARDNRLGCMFVRCAPSSRYTLLFSHGN
AVDLGQMCSFYIGLGSRINCNIFSYDYSGYGVSSGKPSEKNLYADIDAAWQALRTRLDYSSLYMCKPKRSMKRDDTKDTYKLPHRLIEKK
RRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHLKALTALTEQQHQKIIALQNGERSLKSPIQSDLDAFHSGFQTCAKEVLQY
LSRFESWTPREPRCVQLINHLHAVATQFLPTPQLLTQQVPLSKGTGAPSAAGSAAAPCLERAGQKLEPLAYCVPVIQRTQPSAELAAEND
TDTDSGYGGEAEARPDREKGKGAGASRVTIKQEPPGEDSPAPKRMKLDSRGGGSGGGPGGGAAAAAAALLGPDPAAAAALLRPDAALLSS
LVAFGGGGGAPFPQPAAAAAPFCLPFCFLSPSAAAAYVQPFLDKSGLEKYLYPAAAAAPFPLLYPGIPAPAAAAAAAAAAAAAAAAFPCL

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Fusion Gene PPI Analysis for FAM108C1-BHLHE41


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FAM108C1-BHLHE41


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FAM108C1-BHLHE41


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0005586Bipolar Disorder1PSYGENET
TgeneC0024121Lung Neoplasms1CTD_human
TgeneC0242379Malignant neoplasm of lung1CTD_human