Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:BCAT2-AK1 (FusionGDB2 ID:HG587TG203)

Fusion Gene Summary for BCAT2-AK1

Fusion gene summary

Fusion gene information	Fusion gene name: BCAT2-AK1
	Fusion gene ID: hg587tg203
		Hgene	Tgene
	Gene symbol	BCAT2	AK1
	Gene ID	587	203
	Gene name	branched chain amino acid transaminase 2	adenylate kinase 1
	Synonyms	BCAM\|BCATM\|BCT2\|PP18	HTL-S-58j
	Cytomap	('BCAT2')('AK1') 19q13.33	9q34.11
	Type of gene	protein-coding	protein-coding
	Description	branched-chain-amino-acid aminotransferase, mitochondrialbranched chain amino-acid transaminase 2, mitochondrialbranched chain aminotransferase 2, mitochondrialplacental protein 18	adenylate kinase isoenzyme 1ATP-AMP transphosphorylase 1ATP:AMP phosphotransferaseadenylate monophosphate kinaseepididymis secretory sperm binding proteinmyokinasetestis secretory sperm binding protein Li 58j
	Modification date	20200313	20200320
	UniProtAcc	.	P00568
	Ensembl transtripts involved in fusion gene	ENST00000402551, ENST00000601496, ENST00000316273, ENST00000545387, ENST00000598162, ENST00000599246, ENST00000597011,
Fusion gene scores	* DoF score	10 X 9 X 9=810	3 X 2 X 3=18
	# samples	11	3
	** MAII score	log2(11/810*10)=-2.88041838424733 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: BCAT2 [Title/Abstract] AND AK1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	BCAT2(49314240)-AK1(130630791), # samples:2
Anticipated loss of major functional domain due to fusion event.	BCAT2-AK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BCAT2-AK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BCAT2-AK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. BCAT2-AK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	AK1	GO:0006165	nucleoside diphosphate phosphorylation	23416111
Tgene	AK1	GO:0009142	nucleoside triphosphate biosynthetic process	23416111

Fusion gene breakpoints across BCAT2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across AK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	THCA	TCGA-IM-A3ED	BCAT2	chr19	49314240	-	AK1	chr9	130630791	-

Top

Fusion Gene ORF analysis for BCAT2-AK1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000402551	ENST00000223836	BCAT2	chr19	49314240	-	AK1	chr9	130630791	-
5UTR-3CDS	ENST00000402551	ENST00000373156	BCAT2	chr19	49314240	-	AK1	chr9	130630791	-
5UTR-3CDS	ENST00000402551	ENST00000373176	BCAT2	chr19	49314240	-	AK1	chr9	130630791	-
5UTR-3CDS	ENST00000601496	ENST00000223836	BCAT2	chr19	49314240	-	AK1	chr9	130630791	-
5UTR-3CDS	ENST00000601496	ENST00000373156	BCAT2	chr19	49314240	-	AK1	chr9	130630791	-
5UTR-3CDS	ENST00000601496	ENST00000373176	BCAT2	chr19	49314240	-	AK1	chr9	130630791	-
In-frame	ENST00000316273	ENST00000223836	BCAT2	chr19	49314240	-	AK1	chr9	130630791	-
In-frame	ENST00000316273	ENST00000373156	BCAT2	chr19	49314240	-	AK1	chr9	130630791	-
In-frame	ENST00000316273	ENST00000373176	BCAT2	chr19	49314240	-	AK1	chr9	130630791	-
In-frame	ENST00000545387	ENST00000223836	BCAT2	chr19	49314240	-	AK1	chr9	130630791	-
In-frame	ENST00000545387	ENST00000373156	BCAT2	chr19	49314240	-	AK1	chr9	130630791	-
In-frame	ENST00000545387	ENST00000373176	BCAT2	chr19	49314240	-	AK1	chr9	130630791	-
In-frame	ENST00000598162	ENST00000223836	BCAT2	chr19	49314240	-	AK1	chr9	130630791	-
In-frame	ENST00000598162	ENST00000373156	BCAT2	chr19	49314240	-	AK1	chr9	130630791	-
In-frame	ENST00000598162	ENST00000373176	BCAT2	chr19	49314240	-	AK1	chr9	130630791	-
In-frame	ENST00000599246	ENST00000223836	BCAT2	chr19	49314240	-	AK1	chr9	130630791	-
In-frame	ENST00000599246	ENST00000373156	BCAT2	chr19	49314240	-	AK1	chr9	130630791	-
In-frame	ENST00000599246	ENST00000373176	BCAT2	chr19	49314240	-	AK1	chr9	130630791	-
intron-3CDS	ENST00000597011	ENST00000223836	BCAT2	chr19	49314240	-	AK1	chr9	130630791	-
intron-3CDS	ENST00000597011	ENST00000373156	BCAT2	chr19	49314240	-	AK1	chr9	130630791	-
intron-3CDS	ENST00000597011	ENST00000373176	BCAT2	chr19	49314240	-	AK1	chr9	130630791	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000545387	BCAT2	chr19	49314240	-	ENST00000373176	AK1	chr9	130630791	-	1818	29	960	559	133
ENST00000545387	BCAT2	chr19	49314240	-	ENST00000373156	AK1	chr9	130630791	-	299	29	5	289	94
ENST00000545387	BCAT2	chr19	49314240	-	ENST00000223836	AK1	chr9	130630791	-	297	29	5	289	94
ENST00000316273	BCAT2	chr19	49314240	-	ENST00000373176	AK1	chr9	130630791	-	1826	37	968	567	133
ENST00000316273	BCAT2	chr19	49314240	-	ENST00000373156	AK1	chr9	130630791	-	307	37	13	297	94
ENST00000316273	BCAT2	chr19	49314240	-	ENST00000223836	AK1	chr9	130630791	-	305	37	13	297	94
ENST00000599246	BCAT2	chr19	49314240	-	ENST00000373176	AK1	chr9	130630791	-	1835	46	977	576	133
ENST00000599246	BCAT2	chr19	49314240	-	ENST00000373156	AK1	chr9	130630791	-	316	46	22	306	94
ENST00000599246	BCAT2	chr19	49314240	-	ENST00000223836	AK1	chr9	130630791	-	314	46	22	306	94
ENST00000598162	BCAT2	chr19	49314240	-	ENST00000373176	AK1	chr9	130630791	-	1833	44	975	574	133
ENST00000598162	BCAT2	chr19	49314240	-	ENST00000373156	AK1	chr9	130630791	-	314	44	20	304	94
ENST00000598162	BCAT2	chr19	49314240	-	ENST00000223836	AK1	chr9	130630791	-	312	44	20	304	94

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000545387	ENST00000373176	BCAT2	chr19	49314240	-	AK1	chr9	130630791	-	0.9040109	0.09598913
ENST00000545387	ENST00000373156	BCAT2	chr19	49314240	-	AK1	chr9	130630791	-	0.16643089	0.8335691
ENST00000545387	ENST00000223836	BCAT2	chr19	49314240	-	AK1	chr9	130630791	-	0.16292875	0.8370713
ENST00000316273	ENST00000373176	BCAT2	chr19	49314240	-	AK1	chr9	130630791	-	0.9285581	0.07144186
ENST00000316273	ENST00000373156	BCAT2	chr19	49314240	-	AK1	chr9	130630791	-	0.12977558	0.87022436
ENST00000316273	ENST00000223836	BCAT2	chr19	49314240	-	AK1	chr9	130630791	-	0.12804803	0.871952
ENST00000599246	ENST00000373176	BCAT2	chr19	49314240	-	AK1	chr9	130630791	-	0.90919787	0.09080211
ENST00000599246	ENST00000373156	BCAT2	chr19	49314240	-	AK1	chr9	130630791	-	0.1247803	0.8752197
ENST00000599246	ENST00000223836	BCAT2	chr19	49314240	-	AK1	chr9	130630791	-	0.12257613	0.8774238
ENST00000598162	ENST00000373176	BCAT2	chr19	49314240	-	AK1	chr9	130630791	-	0.8892345	0.11076548
ENST00000598162	ENST00000373156	BCAT2	chr19	49314240	-	AK1	chr9	130630791	-	0.12780029	0.87219965
ENST00000598162	ENST00000223836	BCAT2	chr19	49314240	-	AK1	chr9	130630791	-	0.12539916	0.8746008

Top

Fusion Genomic Features for BCAT2-AK1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Top

Fusion Protein Features for BCAT2-AK1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:49314240/chr9:130630791)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	AK1 P00568
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. {ECO:0000255\|HAMAP-Rule:MF_03171, ECO:0000269\|PubMed:23416111}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

AK1

chr19:49314240

chr9:130630791

ENST00000373156

131_141

108

195.0

Region

LID

Tgene

AK1

chr19:49314240

chr9:130630791

ENST00000373176

131_141

108

195.0

Region

LID

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

AK1

chr19:49314240

chr9:130630791

ENST00000373156

18_23

108

195.0

Nucleotide binding

ATP

Tgene

AK1

chr19:49314240

chr9:130630791

ENST00000373156

65_67

108

195.0

Nucleotide binding

AMP

Tgene

AK1

chr19:49314240

chr9:130630791

ENST00000373156

94_97

108

195.0

Nucleotide binding

AMP

Tgene

AK1

chr19:49314240

chr9:130630791

ENST00000373176

18_23

108

195.0

Nucleotide binding

ATP

Tgene

AK1

chr19:49314240

chr9:130630791

ENST00000373176

65_67

108

195.0

Nucleotide binding

AMP

Tgene

AK1

chr19:49314240

chr9:130630791

ENST00000373176

94_97

108

195.0

Nucleotide binding

AMP

Tgene

AK1

chr19:49314240

chr9:130630791

ENST00000373156

38_67

108

195.0

Region

NMP

Tgene

AK1

chr19:49314240

chr9:130630791

ENST00000373176

38_67

108

195.0

Region

NMP

Top

Fusion Gene Sequence for BCAT2-AK1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>9282_9282_1_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000316273_AK1_chr9_130630791_ENST00000223836_length(transcript)=305nt_BP=37nt
CGCCGCACGGATCATGGCCGCAGCCGCTCTGGGGCAGATTGGACAGCCCACACTGCTGCTGTATGTGGACGCAGGCCCTGAGACCATGAC
CCAGCGGCTCTTGAAACGTGGAGAGACCAGCGGGCGTGTGGACGACAATGAGGAGACCATCAAAAAGCGGCTGGAGACCTATTACAAGGC
CACAGAACCTGTCATCGCCTTCTATGAGAAACGTGGCATTGTGCGCAAGGTCAACGCTGAGGGCTCCGTGGACAGTGTCTTCTCCCAGGT
CTGCACCCACCTGGACGCCCTAAAGTAGCAACGCT

>9282_9282_1_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000316273_AK1_chr9_130630791_ENST00000223836_length(amino acids)=94AA_BP=7
MAAAALGQIGQPTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIAFYEKRGIVRKVNAEGSVDSVFSQVCTHL
DALK

--------------------------------------------------------------
>9282_9282_2_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000316273_AK1_chr9_130630791_ENST00000373156_length(transcript)=307nt_BP=37nt
CGCCGCACGGATCATGGCCGCAGCCGCTCTGGGGCAGATTGGACAGCCCACACTGCTGCTGTATGTGGACGCAGGCCCTGAGACCATGAC
CCAGCGGCTCTTGAAACGTGGAGAGACCAGCGGGCGTGTGGACGACAATGAGGAGACCATCAAAAAGCGGCTGGAGACCTATTACAAGGC
CACAGAACCTGTCATCGCCTTCTATGAGAAACGTGGCATTGTGCGCAAGGTCAACGCTGAGGGCTCCGTGGACAGTGTCTTCTCCCAGGT
CTGCACCCACCTGGACGCCCTAAAGTAGCAACGCTGG

>9282_9282_2_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000316273_AK1_chr9_130630791_ENST00000373156_length(amino acids)=94AA_BP=7
MAAAALGQIGQPTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIAFYEKRGIVRKVNAEGSVDSVFSQVCTHL
DALK

--------------------------------------------------------------
>9282_9282_3_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000316273_AK1_chr9_130630791_ENST00000373176_length(transcript)=1826nt_BP=37nt
CGCCGCACGGATCATGGCCGCAGCCGCTCTGGGGCAGATTGGACAGCCCACACTGCTGCTGTATGTGGACGCAGGCCCTGAGACCATGAC
CCAGCGGCTCTTGAAACGTGGAGAGACCAGCGGGCGTGTGGACGACAATGAGGAGACCATCAAAAAGCGGCTGGAGACCTATTACAAGGC
CACAGAACCTGTCATCGCCTTCTATGAGAAACGTGGCATTGTGCGCAAGGTCAACGCTGAGGGCTCCGTGGACAGTGTCTTCTCCCAGGT
CTGCACCCACCTGGACGCCCTAAAGTAGCAACGCTGGAGCCGCTTCCCCAGCTCAGAGCCCCGCCCCACCCCGTCCTGATTCGAGGTCCT
CCTGGCCTGAGCGCAGCGCCTCCACCCTGCCCTGCTGAGCACAGACGGAGGAAGCCGCTTATCCTGTTTTCATGGACAGCTGAGCACTAA
AGGAATTTCTAAGGACATTTGGTTTTACTGCTTTTTCTCTGCTTCCAGTTGGAGTTGATTCATGTGCTTGTGCCTACCTGGCCGCAAGTC
CCCAGCCCCTCAACCCTCCGTTCCTCCTCAGCCTCCCTTTGCCAGCCACCCCTCCTCTAGCTCTGGTGGGAGGCCCGGGGCCCTTCCTCG
CACAGGGCATGCCTGGCCTGAGGACCCGGCGCTGAGTGGCGGGGCCCCTGCTCCGAGGGGCTCATGTTCAGGCAGAACCGGTCCCAGCCT
GGGCTCCTCTGCATCTTGCTCTGTGGCCTTGGCCCTGACCCCCATCGCTCTGAGCATATGTTCCATGCCTGGCCCTTGCCGGGGCCTGGA
CTGCACAGGCAGCAAGGTCATGGTCTGAGTGGGGCTTCCTGGGCAGTTGGGGCGGCCCACGCCAGCTGGCCCAGTGGGTAGTGAATTGGC
TTCCTTGACGCGAGAGGCTCTGAGGGTCTGAAAAGGGCATCTCAATGGCATGGGTGGGTGGGGAGTCAGTCATGTCACTGAAATTGAATG
GGGGAGGCCCAATGAGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAAGCTGAGGCAGGAGGATCCCCTGAGGTCAGGAGTTCGAGAG
CAGCCTGGCCAACATGGCAAAACCCCTTATTTACTAAAAATACAAAAATTAGCCGGGCATGGTGGCATGTGCCTGTATTCCCAGCTACTC
ATGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGTGGAGCTTGCAATGAGCCAAGATTGCGCCACTGCACTCCAGCCTGGGTGACA
GAGCAAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAGAAATTGAATTGGGGGAGTCATGGTCAGGGGTGAGACCTGAAGGACCTCCCC
CTGTGTGGCCCTGGACACAGCCCACCCTCTGTGAGCCGTTTCCAATTCTAAAACAGACTCAATGTCCCCCTCACCCCCACCTCAAGGTCA
GGATGAGAACACACTGAGTGAGGAGTGGACGCTGTCCATTGCCACGGCCATGAGGGCTGGAGACCAGAACAGCATGGCCCGAAGCGTGCG
GGGCCCCGGATGACTTGGGGACACCCCAGAATCCCCTGGGGAGAACCCTTCCTGCGCGCTTTCATTTTTTGACCTCATCACTGAGAAAGG
CTCAATTTGGTGCTCACGTGTCCTTAACACCTGATCTGGCCCAAGCTGGGCTCCCTTTAAGCCAAGAGAGCCTCTTGTGGACCCCGCCTG
CCCGAATGAAATCCGAACAGTTGGGGCTGTTCATGGCAAGTGGGGCTGGTTTTTCATTTCCATTGGTTATTTAAAGTTTCCTTTAAAATA
AACGATTTTAAGTTATAAAAGGTGAA

>9282_9282_3_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000316273_AK1_chr9_130630791_ENST00000373176_length(amino acids)=133AA_BP=
MTPHPPMPLRCPFQTLRASRVKEANSLPTGPAGVGRPNCPGSPTQTMTLLPVQSRPRQGPGMEHMLRAMGVRAKATEQDAEEPRLGPVLP
EHEPLGAGAPPLSAGSSGQACPVRGRAPGLPPELEEGWLAKGG

--------------------------------------------------------------
>9282_9282_4_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000545387_AK1_chr9_130630791_ENST00000223836_length(transcript)=297nt_BP=29nt
GGATCATGGCCGCAGCCGCTCTGGGGCAGATTGGACAGCCCACACTGCTGCTGTATGTGGACGCAGGCCCTGAGACCATGACCCAGCGGC
TCTTGAAACGTGGAGAGACCAGCGGGCGTGTGGACGACAATGAGGAGACCATCAAAAAGCGGCTGGAGACCTATTACAAGGCCACAGAAC
CTGTCATCGCCTTCTATGAGAAACGTGGCATTGTGCGCAAGGTCAACGCTGAGGGCTCCGTGGACAGTGTCTTCTCCCAGGTCTGCACCC
ACCTGGACGCCCTAAAGTAGCAACGCT

>9282_9282_4_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000545387_AK1_chr9_130630791_ENST00000223836_length(amino acids)=94AA_BP=7
MAAAALGQIGQPTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIAFYEKRGIVRKVNAEGSVDSVFSQVCTHL
DALK

--------------------------------------------------------------
>9282_9282_5_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000545387_AK1_chr9_130630791_ENST00000373156_length(transcript)=299nt_BP=29nt
GGATCATGGCCGCAGCCGCTCTGGGGCAGATTGGACAGCCCACACTGCTGCTGTATGTGGACGCAGGCCCTGAGACCATGACCCAGCGGC
TCTTGAAACGTGGAGAGACCAGCGGGCGTGTGGACGACAATGAGGAGACCATCAAAAAGCGGCTGGAGACCTATTACAAGGCCACAGAAC
CTGTCATCGCCTTCTATGAGAAACGTGGCATTGTGCGCAAGGTCAACGCTGAGGGCTCCGTGGACAGTGTCTTCTCCCAGGTCTGCACCC
ACCTGGACGCCCTAAAGTAGCAACGCTGG

>9282_9282_5_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000545387_AK1_chr9_130630791_ENST00000373156_length(amino acids)=94AA_BP=7
MAAAALGQIGQPTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIAFYEKRGIVRKVNAEGSVDSVFSQVCTHL
DALK

--------------------------------------------------------------
>9282_9282_6_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000545387_AK1_chr9_130630791_ENST00000373176_length(transcript)=1818nt_BP=29nt
GGATCATGGCCGCAGCCGCTCTGGGGCAGATTGGACAGCCCACACTGCTGCTGTATGTGGACGCAGGCCCTGAGACCATGACCCAGCGGC
TCTTGAAACGTGGAGAGACCAGCGGGCGTGTGGACGACAATGAGGAGACCATCAAAAAGCGGCTGGAGACCTATTACAAGGCCACAGAAC
CTGTCATCGCCTTCTATGAGAAACGTGGCATTGTGCGCAAGGTCAACGCTGAGGGCTCCGTGGACAGTGTCTTCTCCCAGGTCTGCACCC
ACCTGGACGCCCTAAAGTAGCAACGCTGGAGCCGCTTCCCCAGCTCAGAGCCCCGCCCCACCCCGTCCTGATTCGAGGTCCTCCTGGCCT
GAGCGCAGCGCCTCCACCCTGCCCTGCTGAGCACAGACGGAGGAAGCCGCTTATCCTGTTTTCATGGACAGCTGAGCACTAAAGGAATTT
CTAAGGACATTTGGTTTTACTGCTTTTTCTCTGCTTCCAGTTGGAGTTGATTCATGTGCTTGTGCCTACCTGGCCGCAAGTCCCCAGCCC
CTCAACCCTCCGTTCCTCCTCAGCCTCCCTTTGCCAGCCACCCCTCCTCTAGCTCTGGTGGGAGGCCCGGGGCCCTTCCTCGCACAGGGC
ATGCCTGGCCTGAGGACCCGGCGCTGAGTGGCGGGGCCCCTGCTCCGAGGGGCTCATGTTCAGGCAGAACCGGTCCCAGCCTGGGCTCCT
CTGCATCTTGCTCTGTGGCCTTGGCCCTGACCCCCATCGCTCTGAGCATATGTTCCATGCCTGGCCCTTGCCGGGGCCTGGACTGCACAG
GCAGCAAGGTCATGGTCTGAGTGGGGCTTCCTGGGCAGTTGGGGCGGCCCACGCCAGCTGGCCCAGTGGGTAGTGAATTGGCTTCCTTGA
CGCGAGAGGCTCTGAGGGTCTGAAAAGGGCATCTCAATGGCATGGGTGGGTGGGGAGTCAGTCATGTCACTGAAATTGAATGGGGGAGGC
CCAATGAGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAAGCTGAGGCAGGAGGATCCCCTGAGGTCAGGAGTTCGAGAGCAGCCTGG
CCAACATGGCAAAACCCCTTATTTACTAAAAATACAAAAATTAGCCGGGCATGGTGGCATGTGCCTGTATTCCCAGCTACTCATGAGGCT
GAGGCAGGAGAATGGCGTGAACCCGGGAGGTGGAGCTTGCAATGAGCCAAGATTGCGCCACTGCACTCCAGCCTGGGTGACAGAGCAAGA
CTCCGTCTCAAAAAAAAAAAAAAAAAAAAAGAAATTGAATTGGGGGAGTCATGGTCAGGGGTGAGACCTGAAGGACCTCCCCCTGTGTGG
CCCTGGACACAGCCCACCCTCTGTGAGCCGTTTCCAATTCTAAAACAGACTCAATGTCCCCCTCACCCCCACCTCAAGGTCAGGATGAGA
ACACACTGAGTGAGGAGTGGACGCTGTCCATTGCCACGGCCATGAGGGCTGGAGACCAGAACAGCATGGCCCGAAGCGTGCGGGGCCCCG
GATGACTTGGGGACACCCCAGAATCCCCTGGGGAGAACCCTTCCTGCGCGCTTTCATTTTTTGACCTCATCACTGAGAAAGGCTCAATTT
GGTGCTCACGTGTCCTTAACACCTGATCTGGCCCAAGCTGGGCTCCCTTTAAGCCAAGAGAGCCTCTTGTGGACCCCGCCTGCCCGAATG
AAATCCGAACAGTTGGGGCTGTTCATGGCAAGTGGGGCTGGTTTTTCATTTCCATTGGTTATTTAAAGTTTCCTTTAAAATAAACGATTT
TAAGTTATAAAAGGTGAA

>9282_9282_6_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000545387_AK1_chr9_130630791_ENST00000373176_length(amino acids)=133AA_BP=
MTPHPPMPLRCPFQTLRASRVKEANSLPTGPAGVGRPNCPGSPTQTMTLLPVQSRPRQGPGMEHMLRAMGVRAKATEQDAEEPRLGPVLP
EHEPLGAGAPPLSAGSSGQACPVRGRAPGLPPELEEGWLAKGG

--------------------------------------------------------------
>9282_9282_7_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000598162_AK1_chr9_130630791_ENST00000223836_length(transcript)=312nt_BP=44nt
AGTTACGCGCCGCACGGATCATGGCCGCAGCCGCTCTGGGGCAGATTGGACAGCCCACACTGCTGCTGTATGTGGACGCAGGCCCTGAGA
CCATGACCCAGCGGCTCTTGAAACGTGGAGAGACCAGCGGGCGTGTGGACGACAATGAGGAGACCATCAAAAAGCGGCTGGAGACCTATT
ACAAGGCCACAGAACCTGTCATCGCCTTCTATGAGAAACGTGGCATTGTGCGCAAGGTCAACGCTGAGGGCTCCGTGGACAGTGTCTTCT
CCCAGGTCTGCACCCACCTGGACGCCCTAAAGTAGCAACGCT

>9282_9282_7_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000598162_AK1_chr9_130630791_ENST00000223836_length(amino acids)=94AA_BP=7
MAAAALGQIGQPTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIAFYEKRGIVRKVNAEGSVDSVFSQVCTHL
DALK

--------------------------------------------------------------
>9282_9282_8_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000598162_AK1_chr9_130630791_ENST00000373156_length(transcript)=314nt_BP=44nt
AGTTACGCGCCGCACGGATCATGGCCGCAGCCGCTCTGGGGCAGATTGGACAGCCCACACTGCTGCTGTATGTGGACGCAGGCCCTGAGA
CCATGACCCAGCGGCTCTTGAAACGTGGAGAGACCAGCGGGCGTGTGGACGACAATGAGGAGACCATCAAAAAGCGGCTGGAGACCTATT
ACAAGGCCACAGAACCTGTCATCGCCTTCTATGAGAAACGTGGCATTGTGCGCAAGGTCAACGCTGAGGGCTCCGTGGACAGTGTCTTCT
CCCAGGTCTGCACCCACCTGGACGCCCTAAAGTAGCAACGCTGG

>9282_9282_8_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000598162_AK1_chr9_130630791_ENST00000373156_length(amino acids)=94AA_BP=7
MAAAALGQIGQPTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIAFYEKRGIVRKVNAEGSVDSVFSQVCTHL
DALK

--------------------------------------------------------------
>9282_9282_9_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000598162_AK1_chr9_130630791_ENST00000373176_length(transcript)=1833nt_BP=44nt
AGTTACGCGCCGCACGGATCATGGCCGCAGCCGCTCTGGGGCAGATTGGACAGCCCACACTGCTGCTGTATGTGGACGCAGGCCCTGAGA
CCATGACCCAGCGGCTCTTGAAACGTGGAGAGACCAGCGGGCGTGTGGACGACAATGAGGAGACCATCAAAAAGCGGCTGGAGACCTATT
ACAAGGCCACAGAACCTGTCATCGCCTTCTATGAGAAACGTGGCATTGTGCGCAAGGTCAACGCTGAGGGCTCCGTGGACAGTGTCTTCT
CCCAGGTCTGCACCCACCTGGACGCCCTAAAGTAGCAACGCTGGAGCCGCTTCCCCAGCTCAGAGCCCCGCCCCACCCCGTCCTGATTCG
AGGTCCTCCTGGCCTGAGCGCAGCGCCTCCACCCTGCCCTGCTGAGCACAGACGGAGGAAGCCGCTTATCCTGTTTTCATGGACAGCTGA
GCACTAAAGGAATTTCTAAGGACATTTGGTTTTACTGCTTTTTCTCTGCTTCCAGTTGGAGTTGATTCATGTGCTTGTGCCTACCTGGCC
GCAAGTCCCCAGCCCCTCAACCCTCCGTTCCTCCTCAGCCTCCCTTTGCCAGCCACCCCTCCTCTAGCTCTGGTGGGAGGCCCGGGGCCC
TTCCTCGCACAGGGCATGCCTGGCCTGAGGACCCGGCGCTGAGTGGCGGGGCCCCTGCTCCGAGGGGCTCATGTTCAGGCAGAACCGGTC
CCAGCCTGGGCTCCTCTGCATCTTGCTCTGTGGCCTTGGCCCTGACCCCCATCGCTCTGAGCATATGTTCCATGCCTGGCCCTTGCCGGG
GCCTGGACTGCACAGGCAGCAAGGTCATGGTCTGAGTGGGGCTTCCTGGGCAGTTGGGGCGGCCCACGCCAGCTGGCCCAGTGGGTAGTG
AATTGGCTTCCTTGACGCGAGAGGCTCTGAGGGTCTGAAAAGGGCATCTCAATGGCATGGGTGGGTGGGGAGTCAGTCATGTCACTGAAA
TTGAATGGGGGAGGCCCAATGAGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAAGCTGAGGCAGGAGGATCCCCTGAGGTCAGGAGT
TCGAGAGCAGCCTGGCCAACATGGCAAAACCCCTTATTTACTAAAAATACAAAAATTAGCCGGGCATGGTGGCATGTGCCTGTATTCCCA
GCTACTCATGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGTGGAGCTTGCAATGAGCCAAGATTGCGCCACTGCACTCCAGCCTG
GGTGACAGAGCAAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAGAAATTGAATTGGGGGAGTCATGGTCAGGGGTGAGACCTGAAGGA
CCTCCCCCTGTGTGGCCCTGGACACAGCCCACCCTCTGTGAGCCGTTTCCAATTCTAAAACAGACTCAATGTCCCCCTCACCCCCACCTC
AAGGTCAGGATGAGAACACACTGAGTGAGGAGTGGACGCTGTCCATTGCCACGGCCATGAGGGCTGGAGACCAGAACAGCATGGCCCGAA
GCGTGCGGGGCCCCGGATGACTTGGGGACACCCCAGAATCCCCTGGGGAGAACCCTTCCTGCGCGCTTTCATTTTTTGACCTCATCACTG
AGAAAGGCTCAATTTGGTGCTCACGTGTCCTTAACACCTGATCTGGCCCAAGCTGGGCTCCCTTTAAGCCAAGAGAGCCTCTTGTGGACC
CCGCCTGCCCGAATGAAATCCGAACAGTTGGGGCTGTTCATGGCAAGTGGGGCTGGTTTTTCATTTCCATTGGTTATTTAAAGTTTCCTT
TAAAATAAACGATTTTAAGTTATAAAAGGTGAA

>9282_9282_9_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000598162_AK1_chr9_130630791_ENST00000373176_length(amino acids)=133AA_BP=
MTPHPPMPLRCPFQTLRASRVKEANSLPTGPAGVGRPNCPGSPTQTMTLLPVQSRPRQGPGMEHMLRAMGVRAKATEQDAEEPRLGPVLP
EHEPLGAGAPPLSAGSSGQACPVRGRAPGLPPELEEGWLAKGG

--------------------------------------------------------------
>9282_9282_10_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000599246_AK1_chr9_130630791_ENST00000223836_length(transcript)=314nt_BP=46nt
ACAGTTACGCGCCGCACGGATCATGGCCGCAGCCGCTCTGGGGCAGATTGGACAGCCCACACTGCTGCTGTATGTGGACGCAGGCCCTGA
GACCATGACCCAGCGGCTCTTGAAACGTGGAGAGACCAGCGGGCGTGTGGACGACAATGAGGAGACCATCAAAAAGCGGCTGGAGACCTA
TTACAAGGCCACAGAACCTGTCATCGCCTTCTATGAGAAACGTGGCATTGTGCGCAAGGTCAACGCTGAGGGCTCCGTGGACAGTGTCTT
CTCCCAGGTCTGCACCCACCTGGACGCCCTAAAGTAGCAACGCT

>9282_9282_10_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000599246_AK1_chr9_130630791_ENST00000223836_length(amino acids)=94AA_BP=7
MAAAALGQIGQPTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIAFYEKRGIVRKVNAEGSVDSVFSQVCTHL
DALK

--------------------------------------------------------------
>9282_9282_11_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000599246_AK1_chr9_130630791_ENST00000373156_length(transcript)=316nt_BP=46nt
ACAGTTACGCGCCGCACGGATCATGGCCGCAGCCGCTCTGGGGCAGATTGGACAGCCCACACTGCTGCTGTATGTGGACGCAGGCCCTGA
GACCATGACCCAGCGGCTCTTGAAACGTGGAGAGACCAGCGGGCGTGTGGACGACAATGAGGAGACCATCAAAAAGCGGCTGGAGACCTA
TTACAAGGCCACAGAACCTGTCATCGCCTTCTATGAGAAACGTGGCATTGTGCGCAAGGTCAACGCTGAGGGCTCCGTGGACAGTGTCTT
CTCCCAGGTCTGCACCCACCTGGACGCCCTAAAGTAGCAACGCTGG

>9282_9282_11_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000599246_AK1_chr9_130630791_ENST00000373156_length(amino acids)=94AA_BP=7
MAAAALGQIGQPTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIAFYEKRGIVRKVNAEGSVDSVFSQVCTHL
DALK

--------------------------------------------------------------
>9282_9282_12_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000599246_AK1_chr9_130630791_ENST00000373176_length(transcript)=1835nt_BP=46nt
ACAGTTACGCGCCGCACGGATCATGGCCGCAGCCGCTCTGGGGCAGATTGGACAGCCCACACTGCTGCTGTATGTGGACGCAGGCCCTGA
GACCATGACCCAGCGGCTCTTGAAACGTGGAGAGACCAGCGGGCGTGTGGACGACAATGAGGAGACCATCAAAAAGCGGCTGGAGACCTA
TTACAAGGCCACAGAACCTGTCATCGCCTTCTATGAGAAACGTGGCATTGTGCGCAAGGTCAACGCTGAGGGCTCCGTGGACAGTGTCTT
CTCCCAGGTCTGCACCCACCTGGACGCCCTAAAGTAGCAACGCTGGAGCCGCTTCCCCAGCTCAGAGCCCCGCCCCACCCCGTCCTGATT
CGAGGTCCTCCTGGCCTGAGCGCAGCGCCTCCACCCTGCCCTGCTGAGCACAGACGGAGGAAGCCGCTTATCCTGTTTTCATGGACAGCT
GAGCACTAAAGGAATTTCTAAGGACATTTGGTTTTACTGCTTTTTCTCTGCTTCCAGTTGGAGTTGATTCATGTGCTTGTGCCTACCTGG
CCGCAAGTCCCCAGCCCCTCAACCCTCCGTTCCTCCTCAGCCTCCCTTTGCCAGCCACCCCTCCTCTAGCTCTGGTGGGAGGCCCGGGGC
CCTTCCTCGCACAGGGCATGCCTGGCCTGAGGACCCGGCGCTGAGTGGCGGGGCCCCTGCTCCGAGGGGCTCATGTTCAGGCAGAACCGG
TCCCAGCCTGGGCTCCTCTGCATCTTGCTCTGTGGCCTTGGCCCTGACCCCCATCGCTCTGAGCATATGTTCCATGCCTGGCCCTTGCCG
GGGCCTGGACTGCACAGGCAGCAAGGTCATGGTCTGAGTGGGGCTTCCTGGGCAGTTGGGGCGGCCCACGCCAGCTGGCCCAGTGGGTAG
TGAATTGGCTTCCTTGACGCGAGAGGCTCTGAGGGTCTGAAAAGGGCATCTCAATGGCATGGGTGGGTGGGGAGTCAGTCATGTCACTGA
AATTGAATGGGGGAGGCCCAATGAGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAAGCTGAGGCAGGAGGATCCCCTGAGGTCAGGA
GTTCGAGAGCAGCCTGGCCAACATGGCAAAACCCCTTATTTACTAAAAATACAAAAATTAGCCGGGCATGGTGGCATGTGCCTGTATTCC
CAGCTACTCATGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGTGGAGCTTGCAATGAGCCAAGATTGCGCCACTGCACTCCAGCC
TGGGTGACAGAGCAAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAGAAATTGAATTGGGGGAGTCATGGTCAGGGGTGAGACCTGAAG
GACCTCCCCCTGTGTGGCCCTGGACACAGCCCACCCTCTGTGAGCCGTTTCCAATTCTAAAACAGACTCAATGTCCCCCTCACCCCCACC
TCAAGGTCAGGATGAGAACACACTGAGTGAGGAGTGGACGCTGTCCATTGCCACGGCCATGAGGGCTGGAGACCAGAACAGCATGGCCCG
AAGCGTGCGGGGCCCCGGATGACTTGGGGACACCCCAGAATCCCCTGGGGAGAACCCTTCCTGCGCGCTTTCATTTTTTGACCTCATCAC
TGAGAAAGGCTCAATTTGGTGCTCACGTGTCCTTAACACCTGATCTGGCCCAAGCTGGGCTCCCTTTAAGCCAAGAGAGCCTCTTGTGGA
CCCCGCCTGCCCGAATGAAATCCGAACAGTTGGGGCTGTTCATGGCAAGTGGGGCTGGTTTTTCATTTCCATTGGTTATTTAAAGTTTCC
TTTAAAATAAACGATTTTAAGTTATAAAAGGTGAA

>9282_9282_12_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000599246_AK1_chr9_130630791_ENST00000373176_length(amino acids)=133AA_BP=
MTPHPPMPLRCPFQTLRASRVKEANSLPTGPAGVGRPNCPGSPTQTMTLLPVQSRPRQGPGMEHMLRAMGVRAKATEQDAEEPRLGPVLP
EHEPLGAGAPPLSAGSSGQACPVRGRAPGLPPELEEGWLAKGG

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for BCAT2-AK1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for BCAT2-AK1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for BCAT2-AK1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	BCAT2	C0024776	Maple Syrup Urine Disease	1	CTD_human
Hgene	BCAT2	C0032927	Precancerous Conditions	1	CTD_human
Hgene	BCAT2	C0268568	Classic Maple Syrup Urine Disease	1	CTD_human
Hgene	BCAT2	C0268569	Intermittent Maple Syrup Urine Disease	1	CTD_human
Hgene	BCAT2	C0282313	Condition, Preneoplastic	1	CTD_human
Hgene	BCAT2	C0751285	Maple Syrup Urine Disease, Thiamine Responsive	1	CTD_human
Hgene	BCAT2	C1621920	Intermediate Maple Syrup Urine Disease	1	CTD_human
Tgene		C2675459	Adenylate Kinase Deficiency, Hemolytic Anemia Due To	5	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene		C0151744	Myocardial Ischemia	1	CTD_human
Tgene		C0334634	Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	1	CTD_human
Tgene		C0751958	Lymphoma, Lymphocytic, Intermediate	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:BCAT2-AK1 (FusionGDB2 ID:HG587TG203)

Fusion Gene Summary for BCAT2-AK1

Fusion Gene ORF analysis for BCAT2-AK1

Fusion Genomic Features for BCAT2-AK1

Fusion Protein Features for BCAT2-AK1

Fusion Gene Sequence for BCAT2-AK1

Fusion Gene PPI Analysis for BCAT2-AK1

Related Drugs for BCAT2-AK1

Related Diseases for BCAT2-AK1

Fusion Gene Studies
in Kim Lab