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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BCAT2-AK1 (FusionGDB2 ID:HG587TG203)

Fusion Gene Summary for BCAT2-AK1

check button Fusion gene summary
Fusion gene informationFusion gene name: BCAT2-AK1
Fusion gene ID: hg587tg203
HgeneTgene
Gene symbol

BCAT2

AK1

Gene ID

587

203

Gene namebranched chain amino acid transaminase 2adenylate kinase 1
SynonymsBCAM|BCATM|BCT2|PP18HTL-S-58j
Cytomap('BCAT2')('AK1')

19q13.33

9q34.11

Type of geneprotein-codingprotein-coding
Descriptionbranched-chain-amino-acid aminotransferase, mitochondrialbranched chain amino-acid transaminase 2, mitochondrialbranched chain aminotransferase 2, mitochondrialplacental protein 18adenylate kinase isoenzyme 1ATP-AMP transphosphorylase 1ATP:AMP phosphotransferaseadenylate monophosphate kinaseepididymis secretory sperm binding proteinmyokinasetestis secretory sperm binding protein Li 58j
Modification date2020031320200320
UniProtAcc.

P00568

Ensembl transtripts involved in fusion geneENST00000402551, ENST00000601496, 
ENST00000316273, ENST00000545387, 
ENST00000598162, ENST00000599246, 
ENST00000597011, 
Fusion gene scores* DoF score10 X 9 X 9=8103 X 2 X 3=18
# samples 113
** MAII scorelog2(11/810*10)=-2.88041838424733
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: BCAT2 [Title/Abstract] AND AK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBCAT2(49314240)-AK1(130630791), # samples:2
Anticipated loss of major functional domain due to fusion event.BCAT2-AK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BCAT2-AK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BCAT2-AK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BCAT2-AK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneAK1

GO:0006165

nucleoside diphosphate phosphorylation

23416111

TgeneAK1

GO:0009142

nucleoside triphosphate biosynthetic process

23416111


check buttonFusion gene breakpoints across BCAT2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across AK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4THCATCGA-IM-A3EDBCAT2chr19

49314240

-AK1chr9

130630791

-


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Fusion Gene ORF analysis for BCAT2-AK1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000402551ENST00000223836BCAT2chr19

49314240

-AK1chr9

130630791

-
5UTR-3CDSENST00000402551ENST00000373156BCAT2chr19

49314240

-AK1chr9

130630791

-
5UTR-3CDSENST00000402551ENST00000373176BCAT2chr19

49314240

-AK1chr9

130630791

-
5UTR-3CDSENST00000601496ENST00000223836BCAT2chr19

49314240

-AK1chr9

130630791

-
5UTR-3CDSENST00000601496ENST00000373156BCAT2chr19

49314240

-AK1chr9

130630791

-
5UTR-3CDSENST00000601496ENST00000373176BCAT2chr19

49314240

-AK1chr9

130630791

-
In-frameENST00000316273ENST00000223836BCAT2chr19

49314240

-AK1chr9

130630791

-
In-frameENST00000316273ENST00000373156BCAT2chr19

49314240

-AK1chr9

130630791

-
In-frameENST00000316273ENST00000373176BCAT2chr19

49314240

-AK1chr9

130630791

-
In-frameENST00000545387ENST00000223836BCAT2chr19

49314240

-AK1chr9

130630791

-
In-frameENST00000545387ENST00000373156BCAT2chr19

49314240

-AK1chr9

130630791

-
In-frameENST00000545387ENST00000373176BCAT2chr19

49314240

-AK1chr9

130630791

-
In-frameENST00000598162ENST00000223836BCAT2chr19

49314240

-AK1chr9

130630791

-
In-frameENST00000598162ENST00000373156BCAT2chr19

49314240

-AK1chr9

130630791

-
In-frameENST00000598162ENST00000373176BCAT2chr19

49314240

-AK1chr9

130630791

-
In-frameENST00000599246ENST00000223836BCAT2chr19

49314240

-AK1chr9

130630791

-
In-frameENST00000599246ENST00000373156BCAT2chr19

49314240

-AK1chr9

130630791

-
In-frameENST00000599246ENST00000373176BCAT2chr19

49314240

-AK1chr9

130630791

-
intron-3CDSENST00000597011ENST00000223836BCAT2chr19

49314240

-AK1chr9

130630791

-
intron-3CDSENST00000597011ENST00000373156BCAT2chr19

49314240

-AK1chr9

130630791

-
intron-3CDSENST00000597011ENST00000373176BCAT2chr19

49314240

-AK1chr9

130630791

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000545387BCAT2chr1949314240-ENST00000373176AK1chr9130630791-181829960559133
ENST00000545387BCAT2chr1949314240-ENST00000373156AK1chr9130630791-29929528994
ENST00000545387BCAT2chr1949314240-ENST00000223836AK1chr9130630791-29729528994
ENST00000316273BCAT2chr1949314240-ENST00000373176AK1chr9130630791-182637968567133
ENST00000316273BCAT2chr1949314240-ENST00000373156AK1chr9130630791-307371329794
ENST00000316273BCAT2chr1949314240-ENST00000223836AK1chr9130630791-305371329794
ENST00000599246BCAT2chr1949314240-ENST00000373176AK1chr9130630791-183546977576133
ENST00000599246BCAT2chr1949314240-ENST00000373156AK1chr9130630791-316462230694
ENST00000599246BCAT2chr1949314240-ENST00000223836AK1chr9130630791-314462230694
ENST00000598162BCAT2chr1949314240-ENST00000373176AK1chr9130630791-183344975574133
ENST00000598162BCAT2chr1949314240-ENST00000373156AK1chr9130630791-314442030494
ENST00000598162BCAT2chr1949314240-ENST00000223836AK1chr9130630791-312442030494

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000545387ENST00000373176BCAT2chr1949314240-AK1chr9130630791-0.90401090.09598913
ENST00000545387ENST00000373156BCAT2chr1949314240-AK1chr9130630791-0.166430890.8335691
ENST00000545387ENST00000223836BCAT2chr1949314240-AK1chr9130630791-0.162928750.8370713
ENST00000316273ENST00000373176BCAT2chr1949314240-AK1chr9130630791-0.92855810.07144186
ENST00000316273ENST00000373156BCAT2chr1949314240-AK1chr9130630791-0.129775580.87022436
ENST00000316273ENST00000223836BCAT2chr1949314240-AK1chr9130630791-0.128048030.871952
ENST00000599246ENST00000373176BCAT2chr1949314240-AK1chr9130630791-0.909197870.09080211
ENST00000599246ENST00000373156BCAT2chr1949314240-AK1chr9130630791-0.12478030.8752197
ENST00000599246ENST00000223836BCAT2chr1949314240-AK1chr9130630791-0.122576130.8774238
ENST00000598162ENST00000373176BCAT2chr1949314240-AK1chr9130630791-0.88923450.11076548
ENST00000598162ENST00000373156BCAT2chr1949314240-AK1chr9130630791-0.127800290.87219965
ENST00000598162ENST00000223836BCAT2chr1949314240-AK1chr9130630791-0.125399160.8746008

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Fusion Genomic Features for BCAT2-AK1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for BCAT2-AK1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:49314240/chr9:130630791)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.AK1

P00568

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. {ECO:0000255|HAMAP-Rule:MF_03171, ECO:0000269|PubMed:23416111}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAK1chr19:49314240chr9:130630791ENST0000037315647131_141108195.0RegionLID
TgeneAK1chr19:49314240chr9:130630791ENST0000037317647131_141108195.0RegionLID

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAK1chr19:49314240chr9:130630791ENST000003731564718_23108195.0Nucleotide bindingATP
TgeneAK1chr19:49314240chr9:130630791ENST000003731564765_67108195.0Nucleotide bindingAMP
TgeneAK1chr19:49314240chr9:130630791ENST000003731564794_97108195.0Nucleotide bindingAMP
TgeneAK1chr19:49314240chr9:130630791ENST000003731764718_23108195.0Nucleotide bindingATP
TgeneAK1chr19:49314240chr9:130630791ENST000003731764765_67108195.0Nucleotide bindingAMP
TgeneAK1chr19:49314240chr9:130630791ENST000003731764794_97108195.0Nucleotide bindingAMP
TgeneAK1chr19:49314240chr9:130630791ENST000003731564738_67108195.0RegionNMP
TgeneAK1chr19:49314240chr9:130630791ENST000003731764738_67108195.0RegionNMP


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Fusion Gene Sequence for BCAT2-AK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>9282_9282_1_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000316273_AK1_chr9_130630791_ENST00000223836_length(transcript)=305nt_BP=37nt
CGCCGCACGGATCATGGCCGCAGCCGCTCTGGGGCAGATTGGACAGCCCACACTGCTGCTGTATGTGGACGCAGGCCCTGAGACCATGAC
CCAGCGGCTCTTGAAACGTGGAGAGACCAGCGGGCGTGTGGACGACAATGAGGAGACCATCAAAAAGCGGCTGGAGACCTATTACAAGGC
CACAGAACCTGTCATCGCCTTCTATGAGAAACGTGGCATTGTGCGCAAGGTCAACGCTGAGGGCTCCGTGGACAGTGTCTTCTCCCAGGT

>9282_9282_1_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000316273_AK1_chr9_130630791_ENST00000223836_length(amino acids)=94AA_BP=7
MAAAALGQIGQPTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIAFYEKRGIVRKVNAEGSVDSVFSQVCTHL

--------------------------------------------------------------
>9282_9282_2_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000316273_AK1_chr9_130630791_ENST00000373156_length(transcript)=307nt_BP=37nt
CGCCGCACGGATCATGGCCGCAGCCGCTCTGGGGCAGATTGGACAGCCCACACTGCTGCTGTATGTGGACGCAGGCCCTGAGACCATGAC
CCAGCGGCTCTTGAAACGTGGAGAGACCAGCGGGCGTGTGGACGACAATGAGGAGACCATCAAAAAGCGGCTGGAGACCTATTACAAGGC
CACAGAACCTGTCATCGCCTTCTATGAGAAACGTGGCATTGTGCGCAAGGTCAACGCTGAGGGCTCCGTGGACAGTGTCTTCTCCCAGGT

>9282_9282_2_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000316273_AK1_chr9_130630791_ENST00000373156_length(amino acids)=94AA_BP=7
MAAAALGQIGQPTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIAFYEKRGIVRKVNAEGSVDSVFSQVCTHL

--------------------------------------------------------------
>9282_9282_3_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000316273_AK1_chr9_130630791_ENST00000373176_length(transcript)=1826nt_BP=37nt
CGCCGCACGGATCATGGCCGCAGCCGCTCTGGGGCAGATTGGACAGCCCACACTGCTGCTGTATGTGGACGCAGGCCCTGAGACCATGAC
CCAGCGGCTCTTGAAACGTGGAGAGACCAGCGGGCGTGTGGACGACAATGAGGAGACCATCAAAAAGCGGCTGGAGACCTATTACAAGGC
CACAGAACCTGTCATCGCCTTCTATGAGAAACGTGGCATTGTGCGCAAGGTCAACGCTGAGGGCTCCGTGGACAGTGTCTTCTCCCAGGT
CTGCACCCACCTGGACGCCCTAAAGTAGCAACGCTGGAGCCGCTTCCCCAGCTCAGAGCCCCGCCCCACCCCGTCCTGATTCGAGGTCCT
CCTGGCCTGAGCGCAGCGCCTCCACCCTGCCCTGCTGAGCACAGACGGAGGAAGCCGCTTATCCTGTTTTCATGGACAGCTGAGCACTAA
AGGAATTTCTAAGGACATTTGGTTTTACTGCTTTTTCTCTGCTTCCAGTTGGAGTTGATTCATGTGCTTGTGCCTACCTGGCCGCAAGTC
CCCAGCCCCTCAACCCTCCGTTCCTCCTCAGCCTCCCTTTGCCAGCCACCCCTCCTCTAGCTCTGGTGGGAGGCCCGGGGCCCTTCCTCG
CACAGGGCATGCCTGGCCTGAGGACCCGGCGCTGAGTGGCGGGGCCCCTGCTCCGAGGGGCTCATGTTCAGGCAGAACCGGTCCCAGCCT
GGGCTCCTCTGCATCTTGCTCTGTGGCCTTGGCCCTGACCCCCATCGCTCTGAGCATATGTTCCATGCCTGGCCCTTGCCGGGGCCTGGA
CTGCACAGGCAGCAAGGTCATGGTCTGAGTGGGGCTTCCTGGGCAGTTGGGGCGGCCCACGCCAGCTGGCCCAGTGGGTAGTGAATTGGC
TTCCTTGACGCGAGAGGCTCTGAGGGTCTGAAAAGGGCATCTCAATGGCATGGGTGGGTGGGGAGTCAGTCATGTCACTGAAATTGAATG
GGGGAGGCCCAATGAGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAAGCTGAGGCAGGAGGATCCCCTGAGGTCAGGAGTTCGAGAG
CAGCCTGGCCAACATGGCAAAACCCCTTATTTACTAAAAATACAAAAATTAGCCGGGCATGGTGGCATGTGCCTGTATTCCCAGCTACTC
ATGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGTGGAGCTTGCAATGAGCCAAGATTGCGCCACTGCACTCCAGCCTGGGTGACA
GAGCAAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAGAAATTGAATTGGGGGAGTCATGGTCAGGGGTGAGACCTGAAGGACCTCCCC
CTGTGTGGCCCTGGACACAGCCCACCCTCTGTGAGCCGTTTCCAATTCTAAAACAGACTCAATGTCCCCCTCACCCCCACCTCAAGGTCA
GGATGAGAACACACTGAGTGAGGAGTGGACGCTGTCCATTGCCACGGCCATGAGGGCTGGAGACCAGAACAGCATGGCCCGAAGCGTGCG
GGGCCCCGGATGACTTGGGGACACCCCAGAATCCCCTGGGGAGAACCCTTCCTGCGCGCTTTCATTTTTTGACCTCATCACTGAGAAAGG
CTCAATTTGGTGCTCACGTGTCCTTAACACCTGATCTGGCCCAAGCTGGGCTCCCTTTAAGCCAAGAGAGCCTCTTGTGGACCCCGCCTG
CCCGAATGAAATCCGAACAGTTGGGGCTGTTCATGGCAAGTGGGGCTGGTTTTTCATTTCCATTGGTTATTTAAAGTTTCCTTTAAAATA

>9282_9282_3_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000316273_AK1_chr9_130630791_ENST00000373176_length(amino acids)=133AA_BP=
MTPHPPMPLRCPFQTLRASRVKEANSLPTGPAGVGRPNCPGSPTQTMTLLPVQSRPRQGPGMEHMLRAMGVRAKATEQDAEEPRLGPVLP

--------------------------------------------------------------
>9282_9282_4_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000545387_AK1_chr9_130630791_ENST00000223836_length(transcript)=297nt_BP=29nt
GGATCATGGCCGCAGCCGCTCTGGGGCAGATTGGACAGCCCACACTGCTGCTGTATGTGGACGCAGGCCCTGAGACCATGACCCAGCGGC
TCTTGAAACGTGGAGAGACCAGCGGGCGTGTGGACGACAATGAGGAGACCATCAAAAAGCGGCTGGAGACCTATTACAAGGCCACAGAAC
CTGTCATCGCCTTCTATGAGAAACGTGGCATTGTGCGCAAGGTCAACGCTGAGGGCTCCGTGGACAGTGTCTTCTCCCAGGTCTGCACCC

>9282_9282_4_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000545387_AK1_chr9_130630791_ENST00000223836_length(amino acids)=94AA_BP=7
MAAAALGQIGQPTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIAFYEKRGIVRKVNAEGSVDSVFSQVCTHL

--------------------------------------------------------------
>9282_9282_5_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000545387_AK1_chr9_130630791_ENST00000373156_length(transcript)=299nt_BP=29nt
GGATCATGGCCGCAGCCGCTCTGGGGCAGATTGGACAGCCCACACTGCTGCTGTATGTGGACGCAGGCCCTGAGACCATGACCCAGCGGC
TCTTGAAACGTGGAGAGACCAGCGGGCGTGTGGACGACAATGAGGAGACCATCAAAAAGCGGCTGGAGACCTATTACAAGGCCACAGAAC
CTGTCATCGCCTTCTATGAGAAACGTGGCATTGTGCGCAAGGTCAACGCTGAGGGCTCCGTGGACAGTGTCTTCTCCCAGGTCTGCACCC

>9282_9282_5_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000545387_AK1_chr9_130630791_ENST00000373156_length(amino acids)=94AA_BP=7
MAAAALGQIGQPTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIAFYEKRGIVRKVNAEGSVDSVFSQVCTHL

--------------------------------------------------------------
>9282_9282_6_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000545387_AK1_chr9_130630791_ENST00000373176_length(transcript)=1818nt_BP=29nt
GGATCATGGCCGCAGCCGCTCTGGGGCAGATTGGACAGCCCACACTGCTGCTGTATGTGGACGCAGGCCCTGAGACCATGACCCAGCGGC
TCTTGAAACGTGGAGAGACCAGCGGGCGTGTGGACGACAATGAGGAGACCATCAAAAAGCGGCTGGAGACCTATTACAAGGCCACAGAAC
CTGTCATCGCCTTCTATGAGAAACGTGGCATTGTGCGCAAGGTCAACGCTGAGGGCTCCGTGGACAGTGTCTTCTCCCAGGTCTGCACCC
ACCTGGACGCCCTAAAGTAGCAACGCTGGAGCCGCTTCCCCAGCTCAGAGCCCCGCCCCACCCCGTCCTGATTCGAGGTCCTCCTGGCCT
GAGCGCAGCGCCTCCACCCTGCCCTGCTGAGCACAGACGGAGGAAGCCGCTTATCCTGTTTTCATGGACAGCTGAGCACTAAAGGAATTT
CTAAGGACATTTGGTTTTACTGCTTTTTCTCTGCTTCCAGTTGGAGTTGATTCATGTGCTTGTGCCTACCTGGCCGCAAGTCCCCAGCCC
CTCAACCCTCCGTTCCTCCTCAGCCTCCCTTTGCCAGCCACCCCTCCTCTAGCTCTGGTGGGAGGCCCGGGGCCCTTCCTCGCACAGGGC
ATGCCTGGCCTGAGGACCCGGCGCTGAGTGGCGGGGCCCCTGCTCCGAGGGGCTCATGTTCAGGCAGAACCGGTCCCAGCCTGGGCTCCT
CTGCATCTTGCTCTGTGGCCTTGGCCCTGACCCCCATCGCTCTGAGCATATGTTCCATGCCTGGCCCTTGCCGGGGCCTGGACTGCACAG
GCAGCAAGGTCATGGTCTGAGTGGGGCTTCCTGGGCAGTTGGGGCGGCCCACGCCAGCTGGCCCAGTGGGTAGTGAATTGGCTTCCTTGA
CGCGAGAGGCTCTGAGGGTCTGAAAAGGGCATCTCAATGGCATGGGTGGGTGGGGAGTCAGTCATGTCACTGAAATTGAATGGGGGAGGC
CCAATGAGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAAGCTGAGGCAGGAGGATCCCCTGAGGTCAGGAGTTCGAGAGCAGCCTGG
CCAACATGGCAAAACCCCTTATTTACTAAAAATACAAAAATTAGCCGGGCATGGTGGCATGTGCCTGTATTCCCAGCTACTCATGAGGCT
GAGGCAGGAGAATGGCGTGAACCCGGGAGGTGGAGCTTGCAATGAGCCAAGATTGCGCCACTGCACTCCAGCCTGGGTGACAGAGCAAGA
CTCCGTCTCAAAAAAAAAAAAAAAAAAAAAGAAATTGAATTGGGGGAGTCATGGTCAGGGGTGAGACCTGAAGGACCTCCCCCTGTGTGG
CCCTGGACACAGCCCACCCTCTGTGAGCCGTTTCCAATTCTAAAACAGACTCAATGTCCCCCTCACCCCCACCTCAAGGTCAGGATGAGA
ACACACTGAGTGAGGAGTGGACGCTGTCCATTGCCACGGCCATGAGGGCTGGAGACCAGAACAGCATGGCCCGAAGCGTGCGGGGCCCCG
GATGACTTGGGGACACCCCAGAATCCCCTGGGGAGAACCCTTCCTGCGCGCTTTCATTTTTTGACCTCATCACTGAGAAAGGCTCAATTT
GGTGCTCACGTGTCCTTAACACCTGATCTGGCCCAAGCTGGGCTCCCTTTAAGCCAAGAGAGCCTCTTGTGGACCCCGCCTGCCCGAATG
AAATCCGAACAGTTGGGGCTGTTCATGGCAAGTGGGGCTGGTTTTTCATTTCCATTGGTTATTTAAAGTTTCCTTTAAAATAAACGATTT

>9282_9282_6_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000545387_AK1_chr9_130630791_ENST00000373176_length(amino acids)=133AA_BP=
MTPHPPMPLRCPFQTLRASRVKEANSLPTGPAGVGRPNCPGSPTQTMTLLPVQSRPRQGPGMEHMLRAMGVRAKATEQDAEEPRLGPVLP

--------------------------------------------------------------
>9282_9282_7_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000598162_AK1_chr9_130630791_ENST00000223836_length(transcript)=312nt_BP=44nt
AGTTACGCGCCGCACGGATCATGGCCGCAGCCGCTCTGGGGCAGATTGGACAGCCCACACTGCTGCTGTATGTGGACGCAGGCCCTGAGA
CCATGACCCAGCGGCTCTTGAAACGTGGAGAGACCAGCGGGCGTGTGGACGACAATGAGGAGACCATCAAAAAGCGGCTGGAGACCTATT
ACAAGGCCACAGAACCTGTCATCGCCTTCTATGAGAAACGTGGCATTGTGCGCAAGGTCAACGCTGAGGGCTCCGTGGACAGTGTCTTCT

>9282_9282_7_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000598162_AK1_chr9_130630791_ENST00000223836_length(amino acids)=94AA_BP=7
MAAAALGQIGQPTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIAFYEKRGIVRKVNAEGSVDSVFSQVCTHL

--------------------------------------------------------------
>9282_9282_8_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000598162_AK1_chr9_130630791_ENST00000373156_length(transcript)=314nt_BP=44nt
AGTTACGCGCCGCACGGATCATGGCCGCAGCCGCTCTGGGGCAGATTGGACAGCCCACACTGCTGCTGTATGTGGACGCAGGCCCTGAGA
CCATGACCCAGCGGCTCTTGAAACGTGGAGAGACCAGCGGGCGTGTGGACGACAATGAGGAGACCATCAAAAAGCGGCTGGAGACCTATT
ACAAGGCCACAGAACCTGTCATCGCCTTCTATGAGAAACGTGGCATTGTGCGCAAGGTCAACGCTGAGGGCTCCGTGGACAGTGTCTTCT

>9282_9282_8_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000598162_AK1_chr9_130630791_ENST00000373156_length(amino acids)=94AA_BP=7
MAAAALGQIGQPTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIAFYEKRGIVRKVNAEGSVDSVFSQVCTHL

--------------------------------------------------------------
>9282_9282_9_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000598162_AK1_chr9_130630791_ENST00000373176_length(transcript)=1833nt_BP=44nt
AGTTACGCGCCGCACGGATCATGGCCGCAGCCGCTCTGGGGCAGATTGGACAGCCCACACTGCTGCTGTATGTGGACGCAGGCCCTGAGA
CCATGACCCAGCGGCTCTTGAAACGTGGAGAGACCAGCGGGCGTGTGGACGACAATGAGGAGACCATCAAAAAGCGGCTGGAGACCTATT
ACAAGGCCACAGAACCTGTCATCGCCTTCTATGAGAAACGTGGCATTGTGCGCAAGGTCAACGCTGAGGGCTCCGTGGACAGTGTCTTCT
CCCAGGTCTGCACCCACCTGGACGCCCTAAAGTAGCAACGCTGGAGCCGCTTCCCCAGCTCAGAGCCCCGCCCCACCCCGTCCTGATTCG
AGGTCCTCCTGGCCTGAGCGCAGCGCCTCCACCCTGCCCTGCTGAGCACAGACGGAGGAAGCCGCTTATCCTGTTTTCATGGACAGCTGA
GCACTAAAGGAATTTCTAAGGACATTTGGTTTTACTGCTTTTTCTCTGCTTCCAGTTGGAGTTGATTCATGTGCTTGTGCCTACCTGGCC
GCAAGTCCCCAGCCCCTCAACCCTCCGTTCCTCCTCAGCCTCCCTTTGCCAGCCACCCCTCCTCTAGCTCTGGTGGGAGGCCCGGGGCCC
TTCCTCGCACAGGGCATGCCTGGCCTGAGGACCCGGCGCTGAGTGGCGGGGCCCCTGCTCCGAGGGGCTCATGTTCAGGCAGAACCGGTC
CCAGCCTGGGCTCCTCTGCATCTTGCTCTGTGGCCTTGGCCCTGACCCCCATCGCTCTGAGCATATGTTCCATGCCTGGCCCTTGCCGGG
GCCTGGACTGCACAGGCAGCAAGGTCATGGTCTGAGTGGGGCTTCCTGGGCAGTTGGGGCGGCCCACGCCAGCTGGCCCAGTGGGTAGTG
AATTGGCTTCCTTGACGCGAGAGGCTCTGAGGGTCTGAAAAGGGCATCTCAATGGCATGGGTGGGTGGGGAGTCAGTCATGTCACTGAAA
TTGAATGGGGGAGGCCCAATGAGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAAGCTGAGGCAGGAGGATCCCCTGAGGTCAGGAGT
TCGAGAGCAGCCTGGCCAACATGGCAAAACCCCTTATTTACTAAAAATACAAAAATTAGCCGGGCATGGTGGCATGTGCCTGTATTCCCA
GCTACTCATGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGTGGAGCTTGCAATGAGCCAAGATTGCGCCACTGCACTCCAGCCTG
GGTGACAGAGCAAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAGAAATTGAATTGGGGGAGTCATGGTCAGGGGTGAGACCTGAAGGA
CCTCCCCCTGTGTGGCCCTGGACACAGCCCACCCTCTGTGAGCCGTTTCCAATTCTAAAACAGACTCAATGTCCCCCTCACCCCCACCTC
AAGGTCAGGATGAGAACACACTGAGTGAGGAGTGGACGCTGTCCATTGCCACGGCCATGAGGGCTGGAGACCAGAACAGCATGGCCCGAA
GCGTGCGGGGCCCCGGATGACTTGGGGACACCCCAGAATCCCCTGGGGAGAACCCTTCCTGCGCGCTTTCATTTTTTGACCTCATCACTG
AGAAAGGCTCAATTTGGTGCTCACGTGTCCTTAACACCTGATCTGGCCCAAGCTGGGCTCCCTTTAAGCCAAGAGAGCCTCTTGTGGACC
CCGCCTGCCCGAATGAAATCCGAACAGTTGGGGCTGTTCATGGCAAGTGGGGCTGGTTTTTCATTTCCATTGGTTATTTAAAGTTTCCTT

>9282_9282_9_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000598162_AK1_chr9_130630791_ENST00000373176_length(amino acids)=133AA_BP=
MTPHPPMPLRCPFQTLRASRVKEANSLPTGPAGVGRPNCPGSPTQTMTLLPVQSRPRQGPGMEHMLRAMGVRAKATEQDAEEPRLGPVLP

--------------------------------------------------------------
>9282_9282_10_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000599246_AK1_chr9_130630791_ENST00000223836_length(transcript)=314nt_BP=46nt
ACAGTTACGCGCCGCACGGATCATGGCCGCAGCCGCTCTGGGGCAGATTGGACAGCCCACACTGCTGCTGTATGTGGACGCAGGCCCTGA
GACCATGACCCAGCGGCTCTTGAAACGTGGAGAGACCAGCGGGCGTGTGGACGACAATGAGGAGACCATCAAAAAGCGGCTGGAGACCTA
TTACAAGGCCACAGAACCTGTCATCGCCTTCTATGAGAAACGTGGCATTGTGCGCAAGGTCAACGCTGAGGGCTCCGTGGACAGTGTCTT

>9282_9282_10_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000599246_AK1_chr9_130630791_ENST00000223836_length(amino acids)=94AA_BP=7
MAAAALGQIGQPTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIAFYEKRGIVRKVNAEGSVDSVFSQVCTHL

--------------------------------------------------------------
>9282_9282_11_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000599246_AK1_chr9_130630791_ENST00000373156_length(transcript)=316nt_BP=46nt
ACAGTTACGCGCCGCACGGATCATGGCCGCAGCCGCTCTGGGGCAGATTGGACAGCCCACACTGCTGCTGTATGTGGACGCAGGCCCTGA
GACCATGACCCAGCGGCTCTTGAAACGTGGAGAGACCAGCGGGCGTGTGGACGACAATGAGGAGACCATCAAAAAGCGGCTGGAGACCTA
TTACAAGGCCACAGAACCTGTCATCGCCTTCTATGAGAAACGTGGCATTGTGCGCAAGGTCAACGCTGAGGGCTCCGTGGACAGTGTCTT

>9282_9282_11_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000599246_AK1_chr9_130630791_ENST00000373156_length(amino acids)=94AA_BP=7
MAAAALGQIGQPTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIAFYEKRGIVRKVNAEGSVDSVFSQVCTHL

--------------------------------------------------------------
>9282_9282_12_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000599246_AK1_chr9_130630791_ENST00000373176_length(transcript)=1835nt_BP=46nt
ACAGTTACGCGCCGCACGGATCATGGCCGCAGCCGCTCTGGGGCAGATTGGACAGCCCACACTGCTGCTGTATGTGGACGCAGGCCCTGA
GACCATGACCCAGCGGCTCTTGAAACGTGGAGAGACCAGCGGGCGTGTGGACGACAATGAGGAGACCATCAAAAAGCGGCTGGAGACCTA
TTACAAGGCCACAGAACCTGTCATCGCCTTCTATGAGAAACGTGGCATTGTGCGCAAGGTCAACGCTGAGGGCTCCGTGGACAGTGTCTT
CTCCCAGGTCTGCACCCACCTGGACGCCCTAAAGTAGCAACGCTGGAGCCGCTTCCCCAGCTCAGAGCCCCGCCCCACCCCGTCCTGATT
CGAGGTCCTCCTGGCCTGAGCGCAGCGCCTCCACCCTGCCCTGCTGAGCACAGACGGAGGAAGCCGCTTATCCTGTTTTCATGGACAGCT
GAGCACTAAAGGAATTTCTAAGGACATTTGGTTTTACTGCTTTTTCTCTGCTTCCAGTTGGAGTTGATTCATGTGCTTGTGCCTACCTGG
CCGCAAGTCCCCAGCCCCTCAACCCTCCGTTCCTCCTCAGCCTCCCTTTGCCAGCCACCCCTCCTCTAGCTCTGGTGGGAGGCCCGGGGC
CCTTCCTCGCACAGGGCATGCCTGGCCTGAGGACCCGGCGCTGAGTGGCGGGGCCCCTGCTCCGAGGGGCTCATGTTCAGGCAGAACCGG
TCCCAGCCTGGGCTCCTCTGCATCTTGCTCTGTGGCCTTGGCCCTGACCCCCATCGCTCTGAGCATATGTTCCATGCCTGGCCCTTGCCG
GGGCCTGGACTGCACAGGCAGCAAGGTCATGGTCTGAGTGGGGCTTCCTGGGCAGTTGGGGCGGCCCACGCCAGCTGGCCCAGTGGGTAG
TGAATTGGCTTCCTTGACGCGAGAGGCTCTGAGGGTCTGAAAAGGGCATCTCAATGGCATGGGTGGGTGGGGAGTCAGTCATGTCACTGA
AATTGAATGGGGGAGGCCCAATGAGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAAGCTGAGGCAGGAGGATCCCCTGAGGTCAGGA
GTTCGAGAGCAGCCTGGCCAACATGGCAAAACCCCTTATTTACTAAAAATACAAAAATTAGCCGGGCATGGTGGCATGTGCCTGTATTCC
CAGCTACTCATGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGTGGAGCTTGCAATGAGCCAAGATTGCGCCACTGCACTCCAGCC
TGGGTGACAGAGCAAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAGAAATTGAATTGGGGGAGTCATGGTCAGGGGTGAGACCTGAAG
GACCTCCCCCTGTGTGGCCCTGGACACAGCCCACCCTCTGTGAGCCGTTTCCAATTCTAAAACAGACTCAATGTCCCCCTCACCCCCACC
TCAAGGTCAGGATGAGAACACACTGAGTGAGGAGTGGACGCTGTCCATTGCCACGGCCATGAGGGCTGGAGACCAGAACAGCATGGCCCG
AAGCGTGCGGGGCCCCGGATGACTTGGGGACACCCCAGAATCCCCTGGGGAGAACCCTTCCTGCGCGCTTTCATTTTTTGACCTCATCAC
TGAGAAAGGCTCAATTTGGTGCTCACGTGTCCTTAACACCTGATCTGGCCCAAGCTGGGCTCCCTTTAAGCCAAGAGAGCCTCTTGTGGA
CCCCGCCTGCCCGAATGAAATCCGAACAGTTGGGGCTGTTCATGGCAAGTGGGGCTGGTTTTTCATTTCCATTGGTTATTTAAAGTTTCC

>9282_9282_12_BCAT2-AK1_BCAT2_chr19_49314240_ENST00000599246_AK1_chr9_130630791_ENST00000373176_length(amino acids)=133AA_BP=
MTPHPPMPLRCPFQTLRASRVKEANSLPTGPAGVGRPNCPGSPTQTMTLLPVQSRPRQGPGMEHMLRAMGVRAKATEQDAEEPRLGPVLP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for BCAT2-AK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BCAT2-AK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BCAT2-AK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBCAT2C0024776Maple Syrup Urine Disease1CTD_human
HgeneBCAT2C0032927Precancerous Conditions1CTD_human
HgeneBCAT2C0268568Classic Maple Syrup Urine Disease1CTD_human
HgeneBCAT2C0268569Intermittent Maple Syrup Urine Disease1CTD_human
HgeneBCAT2C0282313Condition, Preneoplastic1CTD_human
HgeneBCAT2C0751285Maple Syrup Urine Disease, Thiamine Responsive1CTD_human
HgeneBCAT2C1621920Intermediate Maple Syrup Urine Disease1CTD_human
TgeneC2675459Adenylate Kinase Deficiency, Hemolytic Anemia Due To5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0151744Myocardial Ischemia1CTD_human
TgeneC0334634Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse1CTD_human
TgeneC0751958Lymphoma, Lymphocytic, Intermediate1CTD_human