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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SIGIRR-DEAF1 (FusionGDB2 ID:HG59307TG10522)

Fusion Gene Summary for SIGIRR-DEAF1

check button Fusion gene summary
Fusion gene informationFusion gene name: SIGIRR-DEAF1
Fusion gene ID: hg59307tg10522
HgeneTgene
Gene symbol

SIGIRR

DEAF1

Gene ID

59307

10522

Gene namesingle Ig and TIR domain containingDEAF1 transcription factor
SynonymsIL-1R8|TIR8MRD24|NUDR|SPN|ZMYND5
Cytomap('SIGIRR')('DEAF1')

11p15.5

11p15.5

Type of geneprotein-codingprotein-coding
Descriptionsingle Ig IL-1-related receptorinterleukin-1 receptor 8 long isoformsingle Ig IL-1R-related moleculesingle immunoglobulin and toll-interleukin 1 receptor (TIR) domainsingle immunoglobulin domain IL1R1 relatedsingle immunoglobulin domain-containing ILdeformed epidermal autoregulatory factor 1 homolognuclear DEAF-1-related transcriptional regulatorsuppressinzinc finger MYND domain-containing protein 5
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000332725, ENST00000382520, 
ENST00000397632, ENST00000431843, 
ENST00000531205, ENST00000529486, 
Fusion gene scores* DoF score4 X 6 X 4=969 X 5 X 7=315
# samples 511
** MAII scorelog2(5/96*10)=-0.941106310946431
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/315*10)=-1.51784830486262
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SIGIRR [Title/Abstract] AND DEAF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSIGIRR(407062)-DEAF1(644654), # samples:2
Anticipated loss of major functional domain due to fusion event.SIGIRR-DEAF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SIGIRR-DEAF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SIGIRR-DEAF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SIGIRR-DEAF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SIGIRR-DEAF1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
SIGIRR-DEAF1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDEAF1

GO:0000122

negative regulation of transcription by RNA polymerase II

24726472

TgeneDEAF1

GO:0033599

regulation of mammary gland epithelial cell proliferation

18826651

TgeneDEAF1

GO:0045892

negative regulation of transcription, DNA-templated

24726472

TgeneDEAF1

GO:0045893

positive regulation of transcription, DNA-templated

24726472


check buttonFusion gene breakpoints across SIGIRR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across DEAF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-1431-01ASIGIRRchr11

406843

-DEAF1chr11

644654

-
ChimerDB4OVTCGA-24-1431-01ASIGIRRchr11

407062

-DEAF1chr11

644654

-
ChimerDB4OVTCGA-24-1431SIGIRRchr11

407061

-DEAF1chr11

644654

-


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Fusion Gene ORF analysis for SIGIRR-DEAF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000332725ENST00000525904SIGIRRchr11

406843

-DEAF1chr11

644654

-
5CDS-intronENST00000332725ENST00000525904SIGIRRchr11

407062

-DEAF1chr11

644654

-
5CDS-intronENST00000332725ENST00000525904SIGIRRchr11

407061

-DEAF1chr11

644654

-
5CDS-intronENST00000382520ENST00000525904SIGIRRchr11

406843

-DEAF1chr11

644654

-
5CDS-intronENST00000382520ENST00000525904SIGIRRchr11

407062

-DEAF1chr11

644654

-
5CDS-intronENST00000382520ENST00000525904SIGIRRchr11

407061

-DEAF1chr11

644654

-
5CDS-intronENST00000397632ENST00000525904SIGIRRchr11

406843

-DEAF1chr11

644654

-
5CDS-intronENST00000397632ENST00000525904SIGIRRchr11

407062

-DEAF1chr11

644654

-
5CDS-intronENST00000397632ENST00000525904SIGIRRchr11

407061

-DEAF1chr11

644654

-
5CDS-intronENST00000431843ENST00000525904SIGIRRchr11

406843

-DEAF1chr11

644654

-
5CDS-intronENST00000431843ENST00000525904SIGIRRchr11

407062

-DEAF1chr11

644654

-
5CDS-intronENST00000431843ENST00000525904SIGIRRchr11

407061

-DEAF1chr11

644654

-
5CDS-intronENST00000531205ENST00000525904SIGIRRchr11

406843

-DEAF1chr11

644654

-
5CDS-intronENST00000531205ENST00000525904SIGIRRchr11

407062

-DEAF1chr11

644654

-
5CDS-intronENST00000531205ENST00000525904SIGIRRchr11

407061

-DEAF1chr11

644654

-
Frame-shiftENST00000332725ENST00000338675SIGIRRchr11

406843

-DEAF1chr11

644654

-
Frame-shiftENST00000332725ENST00000338675SIGIRRchr11

407062

-DEAF1chr11

644654

-
Frame-shiftENST00000332725ENST00000338675SIGIRRchr11

407061

-DEAF1chr11

644654

-
Frame-shiftENST00000332725ENST00000382409SIGIRRchr11

407062

-DEAF1chr11

644654

-
Frame-shiftENST00000332725ENST00000382409SIGIRRchr11

407061

-DEAF1chr11

644654

-
Frame-shiftENST00000382520ENST00000338675SIGIRRchr11

407062

-DEAF1chr11

644654

-
Frame-shiftENST00000382520ENST00000338675SIGIRRchr11

407061

-DEAF1chr11

644654

-
Frame-shiftENST00000382520ENST00000382409SIGIRRchr11

406843

-DEAF1chr11

644654

-
Frame-shiftENST00000397632ENST00000338675SIGIRRchr11

407062

-DEAF1chr11

644654

-
Frame-shiftENST00000397632ENST00000338675SIGIRRchr11

407061

-DEAF1chr11

644654

-
Frame-shiftENST00000397632ENST00000382409SIGIRRchr11

406843

-DEAF1chr11

644654

-
Frame-shiftENST00000431843ENST00000338675SIGIRRchr11

406843

-DEAF1chr11

644654

-
Frame-shiftENST00000431843ENST00000338675SIGIRRchr11

407062

-DEAF1chr11

644654

-
Frame-shiftENST00000431843ENST00000338675SIGIRRchr11

407061

-DEAF1chr11

644654

-
Frame-shiftENST00000431843ENST00000382409SIGIRRchr11

407062

-DEAF1chr11

644654

-
Frame-shiftENST00000431843ENST00000382409SIGIRRchr11

407061

-DEAF1chr11

644654

-
Frame-shiftENST00000531205ENST00000338675SIGIRRchr11

407062

-DEAF1chr11

644654

-
Frame-shiftENST00000531205ENST00000338675SIGIRRchr11

407061

-DEAF1chr11

644654

-
Frame-shiftENST00000531205ENST00000382409SIGIRRchr11

406843

-DEAF1chr11

644654

-
In-frameENST00000332725ENST00000382409SIGIRRchr11

406843

-DEAF1chr11

644654

-
In-frameENST00000382520ENST00000338675SIGIRRchr11

406843

-DEAF1chr11

644654

-
In-frameENST00000382520ENST00000382409SIGIRRchr11

407062

-DEAF1chr11

644654

-
In-frameENST00000382520ENST00000382409SIGIRRchr11

407061

-DEAF1chr11

644654

-
In-frameENST00000397632ENST00000338675SIGIRRchr11

406843

-DEAF1chr11

644654

-
In-frameENST00000397632ENST00000382409SIGIRRchr11

407062

-DEAF1chr11

644654

-
In-frameENST00000397632ENST00000382409SIGIRRchr11

407061

-DEAF1chr11

644654

-
In-frameENST00000431843ENST00000382409SIGIRRchr11

406843

-DEAF1chr11

644654

-
In-frameENST00000531205ENST00000338675SIGIRRchr11

406843

-DEAF1chr11

644654

-
In-frameENST00000531205ENST00000382409SIGIRRchr11

407062

-DEAF1chr11

644654

-
In-frameENST00000531205ENST00000382409SIGIRRchr11

407061

-DEAF1chr11

644654

-
intron-3CDSENST00000529486ENST00000338675SIGIRRchr11

406843

-DEAF1chr11

644654

-
intron-3CDSENST00000529486ENST00000338675SIGIRRchr11

407062

-DEAF1chr11

644654

-
intron-3CDSENST00000529486ENST00000338675SIGIRRchr11

407061

-DEAF1chr11

644654

-
intron-3CDSENST00000529486ENST00000382409SIGIRRchr11

406843

-DEAF1chr11

644654

-
intron-3CDSENST00000529486ENST00000382409SIGIRRchr11

407062

-DEAF1chr11

644654

-
intron-3CDSENST00000529486ENST00000382409SIGIRRchr11

407061

-DEAF1chr11

644654

-
intron-intronENST00000529486ENST00000525904SIGIRRchr11

406843

-DEAF1chr11

644654

-
intron-intronENST00000529486ENST00000525904SIGIRRchr11

407062

-DEAF1chr11

644654

-
intron-intronENST00000529486ENST00000525904SIGIRRchr11

407061

-DEAF1chr11

644654

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000397632SIGIRRchr11407062-ENST00000382409DEAF1chr11644654-133591365997310
ENST00000531205SIGIRRchr11407062-ENST00000382409DEAF1chr11644654-12538314915303
ENST00000382520SIGIRRchr11407062-ENST00000382409DEAF1chr11644654-133591365997310
ENST00000397632SIGIRRchr11407061-ENST00000382409DEAF1chr11644654-133591365997310
ENST00000531205SIGIRRchr11407061-ENST00000382409DEAF1chr11644654-12538314915303
ENST00000382520SIGIRRchr11407061-ENST00000382409DEAF1chr11644654-133591365997310
ENST00000431843SIGIRRchr11406843-ENST00000382409DEAF1chr11644654-160811861871290367
ENST00000397632SIGIRRchr11406843-ENST00000338675DEAF1chr11644654-14861064651168367
ENST00000332725SIGIRRchr11406843-ENST00000382409DEAF1chr11644654-152711051061209367
ENST00000531205SIGIRRchr11406843-ENST00000338675DEAF1chr11644654-140498241086360
ENST00000382520SIGIRRchr11406843-ENST00000338675DEAF1chr11644654-14861064651168367

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000397632ENST00000382409SIGIRRchr11407062-DEAF1chr11644654-0.0469318550.9530681
ENST00000531205ENST00000382409SIGIRRchr11407062-DEAF1chr11644654-0.043255910.95674413
ENST00000382520ENST00000382409SIGIRRchr11407062-DEAF1chr11644654-0.0469318550.9530681
ENST00000397632ENST00000382409SIGIRRchr11407061-DEAF1chr11644654-0.0469318550.9530681
ENST00000531205ENST00000382409SIGIRRchr11407061-DEAF1chr11644654-0.043255910.95674413
ENST00000382520ENST00000382409SIGIRRchr11407061-DEAF1chr11644654-0.0469318550.9530681
ENST00000431843ENST00000382409SIGIRRchr11406843-DEAF1chr11644654-0.0495935160.9504065
ENST00000397632ENST00000338675SIGIRRchr11406843-DEAF1chr11644654-0.0524592330.9475408
ENST00000332725ENST00000382409SIGIRRchr11406843-DEAF1chr11644654-0.052912410.94708765
ENST00000531205ENST00000338675SIGIRRchr11406843-DEAF1chr11644654-0.0506337430.9493663
ENST00000382520ENST00000338675SIGIRRchr11406843-DEAF1chr11644654-0.0524592330.9475408

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Fusion Genomic Features for SIGIRR-DEAF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for SIGIRR-DEAF1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:407062/chr11:644654)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSIGIRRchr11:406843chr11:644654ENST00000332725-8109_109293411.0DomainNote=Ig-like C2-type
HgeneSIGIRRchr11:406843chr11:644654ENST00000397632-8109_109293411.0DomainNote=Ig-like C2-type
HgeneSIGIRRchr11:406843chr11:644654ENST00000431843-8109_109293411.0DomainNote=Ig-like C2-type
HgeneSIGIRRchr11:407061chr11:644654ENST00000332725-7109_109242411.0DomainNote=Ig-like C2-type
HgeneSIGIRRchr11:407061chr11:644654ENST00000397632-7109_109242411.0DomainNote=Ig-like C2-type
HgeneSIGIRRchr11:407061chr11:644654ENST00000431843-7109_109242411.0DomainNote=Ig-like C2-type
HgeneSIGIRRchr11:407062chr11:644654ENST00000332725-7109_109242411.0DomainNote=Ig-like C2-type
HgeneSIGIRRchr11:407062chr11:644654ENST00000397632-7109_109242411.0DomainNote=Ig-like C2-type
HgeneSIGIRRchr11:407062chr11:644654ENST00000431843-7109_109242411.0DomainNote=Ig-like C2-type
HgeneSIGIRRchr11:406843chr11:644654ENST00000332725-8101_118293411.0Topological domainExtracellular
HgeneSIGIRRchr11:406843chr11:644654ENST00000397632-8101_118293411.0Topological domainExtracellular
HgeneSIGIRRchr11:406843chr11:644654ENST00000431843-8101_118293411.0Topological domainExtracellular
HgeneSIGIRRchr11:407061chr11:644654ENST00000332725-7101_118242411.0Topological domainExtracellular
HgeneSIGIRRchr11:407061chr11:644654ENST00000397632-7101_118242411.0Topological domainExtracellular
HgeneSIGIRRchr11:407061chr11:644654ENST00000431843-7101_118242411.0Topological domainExtracellular
HgeneSIGIRRchr11:407062chr11:644654ENST00000332725-7101_118242411.0Topological domainExtracellular
HgeneSIGIRRchr11:407062chr11:644654ENST00000397632-7101_118242411.0Topological domainExtracellular
HgeneSIGIRRchr11:407062chr11:644654ENST00000431843-7101_118242411.0Topological domainExtracellular
HgeneSIGIRRchr11:406843chr11:644654ENST00000332725-810119_139293411.0TransmembraneHelical%3B Signal-anchor for type III membrane protein
HgeneSIGIRRchr11:406843chr11:644654ENST00000397632-810119_139293411.0TransmembraneHelical%3B Signal-anchor for type III membrane protein
HgeneSIGIRRchr11:406843chr11:644654ENST00000431843-810119_139293411.0TransmembraneHelical%3B Signal-anchor for type III membrane protein
HgeneSIGIRRchr11:407061chr11:644654ENST00000332725-710119_139242411.0TransmembraneHelical%3B Signal-anchor for type III membrane protein
HgeneSIGIRRchr11:407061chr11:644654ENST00000397632-710119_139242411.0TransmembraneHelical%3B Signal-anchor for type III membrane protein
HgeneSIGIRRchr11:407061chr11:644654ENST00000431843-710119_139242411.0TransmembraneHelical%3B Signal-anchor for type III membrane protein
HgeneSIGIRRchr11:407062chr11:644654ENST00000332725-710119_139242411.0TransmembraneHelical%3B Signal-anchor for type III membrane protein
HgeneSIGIRRchr11:407062chr11:644654ENST00000397632-710119_139242411.0TransmembraneHelical%3B Signal-anchor for type III membrane protein
HgeneSIGIRRchr11:407062chr11:644654ENST00000431843-710119_139242411.0TransmembraneHelical%3B Signal-anchor for type III membrane protein
TgeneDEAF1chr11:406843chr11:644654ENST00000338675911504_540456491.0Zinc fingerMYND-type
TgeneDEAF1chr11:407061chr11:644654ENST00000338675911504_540456491.0Zinc fingerMYND-type
TgeneDEAF1chr11:407062chr11:644654ENST00000338675911504_540456491.0Zinc fingerMYND-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSIGIRRchr11:406843chr11:644654ENST00000332725-810163_307293411.0DomainTIR
HgeneSIGIRRchr11:406843chr11:644654ENST00000397632-810163_307293411.0DomainTIR
HgeneSIGIRRchr11:406843chr11:644654ENST00000431843-810163_307293411.0DomainTIR
HgeneSIGIRRchr11:407061chr11:644654ENST00000332725-710163_307242411.0DomainTIR
HgeneSIGIRRchr11:407061chr11:644654ENST00000397632-710163_307242411.0DomainTIR
HgeneSIGIRRchr11:407061chr11:644654ENST00000431843-710163_307242411.0DomainTIR
HgeneSIGIRRchr11:407062chr11:644654ENST00000332725-710163_307242411.0DomainTIR
HgeneSIGIRRchr11:407062chr11:644654ENST00000397632-710163_307242411.0DomainTIR
HgeneSIGIRRchr11:407062chr11:644654ENST00000431843-710163_307242411.0DomainTIR
HgeneSIGIRRchr11:406843chr11:644654ENST00000332725-810140_410293411.0Topological domainCytoplasmic
HgeneSIGIRRchr11:406843chr11:644654ENST00000397632-810140_410293411.0Topological domainCytoplasmic
HgeneSIGIRRchr11:406843chr11:644654ENST00000431843-810140_410293411.0Topological domainCytoplasmic
HgeneSIGIRRchr11:407061chr11:644654ENST00000332725-710140_410242411.0Topological domainCytoplasmic
HgeneSIGIRRchr11:407061chr11:644654ENST00000397632-710140_410242411.0Topological domainCytoplasmic
HgeneSIGIRRchr11:407061chr11:644654ENST00000431843-710140_410242411.0Topological domainCytoplasmic
HgeneSIGIRRchr11:407062chr11:644654ENST00000332725-710140_410242411.0Topological domainCytoplasmic
HgeneSIGIRRchr11:407062chr11:644654ENST00000397632-710140_410242411.0Topological domainCytoplasmic
HgeneSIGIRRchr11:407062chr11:644654ENST00000431843-710140_410242411.0Topological domainCytoplasmic
TgeneDEAF1chr11:406843chr11:644654ENST000003386759112_122456491.0Compositional biasNote=Ala-rich
TgeneDEAF1chr11:406843chr11:644654ENST00000338675911383_439456491.0Compositional biasNote=Pro-rich
TgeneDEAF1chr11:406843chr11:644654ENST0000038240910122_122531566.0Compositional biasNote=Ala-rich
TgeneDEAF1chr11:406843chr11:644654ENST000003824091012383_439531566.0Compositional biasNote=Pro-rich
TgeneDEAF1chr11:407061chr11:644654ENST000003386759112_122456491.0Compositional biasNote=Ala-rich
TgeneDEAF1chr11:407061chr11:644654ENST00000338675911383_439456491.0Compositional biasNote=Pro-rich
TgeneDEAF1chr11:407061chr11:644654ENST0000038240910122_122531566.0Compositional biasNote=Ala-rich
TgeneDEAF1chr11:407061chr11:644654ENST000003824091012383_439531566.0Compositional biasNote=Pro-rich
TgeneDEAF1chr11:407062chr11:644654ENST000003386759112_122456491.0Compositional biasNote=Ala-rich
TgeneDEAF1chr11:407062chr11:644654ENST00000338675911383_439456491.0Compositional biasNote=Pro-rich
TgeneDEAF1chr11:407062chr11:644654ENST0000038240910122_122531566.0Compositional biasNote=Ala-rich
TgeneDEAF1chr11:407062chr11:644654ENST000003824091012383_439531566.0Compositional biasNote=Pro-rich
TgeneDEAF1chr11:406843chr11:644654ENST00000338675911193_273456491.0DomainSAND
TgeneDEAF1chr11:406843chr11:644654ENST000003824091012193_273531566.0DomainSAND
TgeneDEAF1chr11:407061chr11:644654ENST00000338675911193_273456491.0DomainSAND
TgeneDEAF1chr11:407061chr11:644654ENST000003824091012193_273531566.0DomainSAND
TgeneDEAF1chr11:407062chr11:644654ENST00000338675911193_273456491.0DomainSAND
TgeneDEAF1chr11:407062chr11:644654ENST000003824091012193_273531566.0DomainSAND
TgeneDEAF1chr11:406843chr11:644654ENST00000338675911301_316456491.0MotifNuclear localization signal
TgeneDEAF1chr11:406843chr11:644654ENST000003824091012301_316531566.0MotifNuclear localization signal
TgeneDEAF1chr11:407061chr11:644654ENST00000338675911301_316456491.0MotifNuclear localization signal
TgeneDEAF1chr11:407061chr11:644654ENST000003824091012301_316531566.0MotifNuclear localization signal
TgeneDEAF1chr11:407062chr11:644654ENST00000338675911301_316456491.0MotifNuclear localization signal
TgeneDEAF1chr11:407062chr11:644654ENST000003824091012301_316531566.0MotifNuclear localization signal
TgeneDEAF1chr11:406843chr11:644654ENST000003824091012504_540531566.0Zinc fingerMYND-type
TgeneDEAF1chr11:407061chr11:644654ENST000003824091012504_540531566.0Zinc fingerMYND-type
TgeneDEAF1chr11:407062chr11:644654ENST000003824091012504_540531566.0Zinc fingerMYND-type


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Fusion Gene Sequence for SIGIRR-DEAF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>81834_81834_1_SIGIRR-DEAF1_SIGIRR_chr11_406843_ENST00000332725_DEAF1_chr11_644654_ENST00000382409_length(transcript)=1527nt_BP=1105nt
GTTGCCGCTGCGCACCTGGCTCAGGTGAGCTGCCCCGCCCCCGCCCGGCGCGAGCCCCAGGTCCTGGCAGCAGCCTCTGACCTGTCCAGG
TGCCCTGTCCAGCTGACTGCAAGGACAGAGAGGAGTCCTGCCCAGCTCTTGGATCAGTCTGCTGGCCGAGGAGCCCGGTGGAGCCAGGGG
TGACCCTGGAGCCCAGCCTGCCCCGAGGAGGCCCCGGCTCAGAGCCATGCCAGGTGTCTGTGATAGGGCCCCTGACTTCCTCTCCCCGTC
TGAAGACCAGGTGCTGAGGCCTGCCTTGGGCAGCTCAGTGGCTCTGAACTGCACGGCTTGGGTAGTCTCTGGGCCCCACTGCTCCCTGCC
TTCAGTCCAGTGGCTGAAAGACGGGCTTCCATTGGGAATTGGGGGCCACTACAGCCTCCACGAGTACTCCTGGGTCAAGGCCAACCTGTC
AGAGGTGCTTGTGTCCAGTGTCCTGGGGGTCAACGTGACCAGCACTGAAGTCTATGGGGCCTTCACCTGCTCCATCCAGAACATCAGCTT
CTCCTCCTTCACTCTTCAGAGAGCTGGCCCTACAAGCCACGTGGCTGCGGTGCTGGCCTCCCTCCTGGTCCTGCTGGCCCTGCTGCTGGC
CGCCCTGCTCTATGTCAAGTGCCGTCTCAACGTGCTGCTCTGGTACCAGGACGCGTATGGGGAGGTGGAGATAAACGACGGGAAGCTCTA
CGACGCCTACGTCTCCTACAGCGACTGCCCCGAGGACCGCAAGTTCGTGAACTTCATCCTAAAGCCGCAGCTGGAGCGGCGTCGGGGCTA
CAAGCTCTTCCTGGACGACCGCGACCTCCTGCCGCGCGCTGAGCCCTCCGCCGACCTCTTGGTGAACCTGAGCCGCTGCCGACGCCTCAT
CGTGGTGCTTTCGGACGCCTTCCTGAGCCGGGCCTGGTGCAGCCACAGCTTCCGGGAGGGCCTGTGCCGGCTGCTGGAGCTCACCCGCAG
ACCCATCTTCATCACCTTCGAGGGCCAGAGGCGCGACCCCGCGCACCCGGCGCTCCGCCTGCTGCGCCAGCACCGCCACCTGGTGACCTT
GCTGCTCTGGAGGCCCGGCTCCGTGGACTGGAAGGATCACCAGCACATATGCGGCCAGTCAGCAGCTGTCACCGTCCAGGCAGACGAAGT
CCACGTGGCTGAAAGCGTGATGGAGAAGGTGACCGTGTGAGGCTCCATCGGCCGCCCTGGGAGCTGGGGCCCCTCGCACTCCTGTGAGGC
TTTTGCAGGTCGAAGGCCCCCCTGAGGACTCTGGGGGGACGTTGAGAAGAGGGGTGTGGGAAGGTAAAGAAACTTGCTGGACAAGTCATT
AACACACTTTAAGCGAATGGTGCCCTGGGAAGCGCACTCCCCCTGCCCGGGCCCCCTGCCCGCTCGCGGACAGATTTTTTATCCCTGGGA
TCATGAGCGTCCGGTCTTGCCCACAGGGCCTGTGCTGCGACGCACATACATACGTGTTGTGTCTGTCAATAAAGTGTAAATAAGGTC

>81834_81834_1_SIGIRR-DEAF1_SIGIRR_chr11_406843_ENST00000332725_DEAF1_chr11_644654_ENST00000382409_length(amino acids)=367AA_BP=333
MQGQRGVLPSSWISLLAEEPGGARGDPGAQPAPRRPRLRAMPGVCDRAPDFLSPSEDQVLRPALGSSVALNCTAWVVSGPHCSLPSVQWL
KDGLPLGIGGHYSLHEYSWVKANLSEVLVSSVLGVNVTSTEVYGAFTCSIQNISFSSFTLQRAGPTSHVAAVLASLLVLLALLLAALLYV
KCRLNVLLWYQDAYGEVEINDGKLYDAYVSYSDCPEDRKFVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVVLSD
AFLSRAWCSHSFREGLCRLLELTRRPIFITFEGQRRDPAHPALRLLRQHRHLVTLLLWRPGSVDWKDHQHICGQSAAVTVQADEVHVAES
VMEKVTV

--------------------------------------------------------------
>81834_81834_2_SIGIRR-DEAF1_SIGIRR_chr11_406843_ENST00000382520_DEAF1_chr11_644654_ENST00000338675_length(transcript)=1486nt_BP=1064nt
GGTGAGTGGCGGTCGCCATCAGACCCGCGAAGCCTCTGACCTGTCCAGGTGCCCTGTCCAGCTGACTGCAAGGACAGAGAGGAGTCCTGC
CCAGCTCTTGGATCAGTCTGCTGGCCGAGGAGCCCGGTGGAGCCAGGGGTGACCCTGGAGCCCAGCCTGCCCCGAGGAGGCCCCGGCTCA
GAGCCATGCCAGGTGTCTGTGATAGGGCCCCTGACTTCCTCTCCCCGTCTGAAGACCAGGTGCTGAGGCCTGCCTTGGGCAGCTCAGTGG
CTCTGAACTGCACGGCTTGGGTAGTCTCTGGGCCCCACTGCTCCCTGCCTTCAGTCCAGTGGCTGAAAGACGGGCTTCCATTGGGAATTG
GGGGCCACTACAGCCTCCACGAGTACTCCTGGGTCAAGGCCAACCTGTCAGAGGTGCTTGTGTCCAGTGTCCTGGGGGTCAACGTGACCA
GCACTGAAGTCTATGGGGCCTTCACCTGCTCCATCCAGAACATCAGCTTCTCCTCCTTCACTCTTCAGAGAGCTGGCCCTACAAGCCACG
TGGCTGCGGTGCTGGCCTCCCTCCTGGTCCTGCTGGCCCTGCTGCTGGCCGCCCTGCTCTATGTCAAGTGCCGTCTCAACGTGCTGCTCT
GGTACCAGGACGCGTATGGGGAGGTGGAGATAAACGACGGGAAGCTCTACGACGCCTACGTCTCCTACAGCGACTGCCCCGAGGACCGCA
AGTTCGTGAACTTCATCCTAAAGCCGCAGCTGGAGCGGCGTCGGGGCTACAAGCTCTTCCTGGACGACCGCGACCTCCTGCCGCGCGCTG
AGCCCTCCGCCGACCTCTTGGTGAACCTGAGCCGCTGCCGACGCCTCATCGTGGTGCTTTCGGACGCCTTCCTGAGCCGGGCCTGGTGCA
GCCACAGCTTCCGGGAGGGCCTGTGCCGGCTGCTGGAGCTCACCCGCAGACCCATCTTCATCACCTTCGAGGGCCAGAGGCGCGACCCCG
CGCACCCGGCGCTCCGCCTGCTGCGCCAGCACCGCCACCTGGTGACCTTGCTGCTCTGGAGGCCCGGCTCCGTGGACTGGAAGGATCACC
AGCACATATGCGGCCAGTCAGCAGCTGTCACCGTCCAGGCAGACGAAGTCCACGTGGCTGAAAGCGTGATGGAGAAGGTGACCGTGTGAG
GCTCCATCGGCCGCCCTGGGAGCTGGGGCCCCTCGCACTCCTGTGAGGCTTTTGCAGGTCGAAGGCCCCCCTGAGGACTCTGGGGGGACG
TTGAGAAGAGGGGTGTGGGAAGGTAAAGAAACTTGCTGGACAAGTCATTAACACACTTTAAGCGAATGGTGCCCTGGGAAGCGCACTCCC
CCTGCCCGGGCCCCCTGCCCGCTCGCGGACAGATTTTTTATCCCTGGGATCATGAGCGTCCGGTCTTGCCCACAGGGCCTGTGCTGCGAC
GCACATACATACGTGTTGTGTCTGTCAATAAAGTGTAAATAAGGTC

>81834_81834_2_SIGIRR-DEAF1_SIGIRR_chr11_406843_ENST00000382520_DEAF1_chr11_644654_ENST00000338675_length(amino acids)=367AA_BP=333
MQGQRGVLPSSWISLLAEEPGGARGDPGAQPAPRRPRLRAMPGVCDRAPDFLSPSEDQVLRPALGSSVALNCTAWVVSGPHCSLPSVQWL
KDGLPLGIGGHYSLHEYSWVKANLSEVLVSSVLGVNVTSTEVYGAFTCSIQNISFSSFTLQRAGPTSHVAAVLASLLVLLALLLAALLYV
KCRLNVLLWYQDAYGEVEINDGKLYDAYVSYSDCPEDRKFVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVVLSD
AFLSRAWCSHSFREGLCRLLELTRRPIFITFEGQRRDPAHPALRLLRQHRHLVTLLLWRPGSVDWKDHQHICGQSAAVTVQADEVHVAES
VMEKVTV

--------------------------------------------------------------
>81834_81834_3_SIGIRR-DEAF1_SIGIRR_chr11_406843_ENST00000397632_DEAF1_chr11_644654_ENST00000338675_length(transcript)=1486nt_BP=1064nt
GGTGAGTGGCGGTCGCCATCAGACCCGCGAAGCCTCTGACCTGTCCAGGTGCCCTGTCCAGCTGACTGCAAGGACAGAGAGGAGTCCTGC
CCAGCTCTTGGATCAGTCTGCTGGCCGAGGAGCCCGGTGGAGCCAGGGGTGACCCTGGAGCCCAGCCTGCCCCGAGGAGGCCCCGGCTCA
GAGCCATGCCAGGTGTCTGTGATAGGGCCCCTGACTTCCTCTCCCCGTCTGAAGACCAGGTGCTGAGGCCTGCCTTGGGCAGCTCAGTGG
CTCTGAACTGCACGGCTTGGGTAGTCTCTGGGCCCCACTGCTCCCTGCCTTCAGTCCAGTGGCTGAAAGACGGGCTTCCATTGGGAATTG
GGGGCCACTACAGCCTCCACGAGTACTCCTGGGTCAAGGCCAACCTGTCAGAGGTGCTTGTGTCCAGTGTCCTGGGGGTCAACGTGACCA
GCACTGAAGTCTATGGGGCCTTCACCTGCTCCATCCAGAACATCAGCTTCTCCTCCTTCACTCTTCAGAGAGCTGGCCCTACAAGCCACG
TGGCTGCGGTGCTGGCCTCCCTCCTGGTCCTGCTGGCCCTGCTGCTGGCCGCCCTGCTCTATGTCAAGTGCCGTCTCAACGTGCTGCTCT
GGTACCAGGACGCGTATGGGGAGGTGGAGATAAACGACGGGAAGCTCTACGACGCCTACGTCTCCTACAGCGACTGCCCCGAGGACCGCA
AGTTCGTGAACTTCATCCTAAAGCCGCAGCTGGAGCGGCGTCGGGGCTACAAGCTCTTCCTGGACGACCGCGACCTCCTGCCGCGCGCTG
AGCCCTCCGCCGACCTCTTGGTGAACCTGAGCCGCTGCCGACGCCTCATCGTGGTGCTTTCGGACGCCTTCCTGAGCCGGGCCTGGTGCA
GCCACAGCTTCCGGGAGGGCCTGTGCCGGCTGCTGGAGCTCACCCGCAGACCCATCTTCATCACCTTCGAGGGCCAGAGGCGCGACCCCG
CGCACCCGGCGCTCCGCCTGCTGCGCCAGCACCGCCACCTGGTGACCTTGCTGCTCTGGAGGCCCGGCTCCGTGGACTGGAAGGATCACC
AGCACATATGCGGCCAGTCAGCAGCTGTCACCGTCCAGGCAGACGAAGTCCACGTGGCTGAAAGCGTGATGGAGAAGGTGACCGTGTGAG
GCTCCATCGGCCGCCCTGGGAGCTGGGGCCCCTCGCACTCCTGTGAGGCTTTTGCAGGTCGAAGGCCCCCCTGAGGACTCTGGGGGGACG
TTGAGAAGAGGGGTGTGGGAAGGTAAAGAAACTTGCTGGACAAGTCATTAACACACTTTAAGCGAATGGTGCCCTGGGAAGCGCACTCCC
CCTGCCCGGGCCCCCTGCCCGCTCGCGGACAGATTTTTTATCCCTGGGATCATGAGCGTCCGGTCTTGCCCACAGGGCCTGTGCTGCGAC
GCACATACATACGTGTTGTGTCTGTCAATAAAGTGTAAATAAGGTC

>81834_81834_3_SIGIRR-DEAF1_SIGIRR_chr11_406843_ENST00000397632_DEAF1_chr11_644654_ENST00000338675_length(amino acids)=367AA_BP=333
MQGQRGVLPSSWISLLAEEPGGARGDPGAQPAPRRPRLRAMPGVCDRAPDFLSPSEDQVLRPALGSSVALNCTAWVVSGPHCSLPSVQWL
KDGLPLGIGGHYSLHEYSWVKANLSEVLVSSVLGVNVTSTEVYGAFTCSIQNISFSSFTLQRAGPTSHVAAVLASLLVLLALLLAALLYV
KCRLNVLLWYQDAYGEVEINDGKLYDAYVSYSDCPEDRKFVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVVLSD
AFLSRAWCSHSFREGLCRLLELTRRPIFITFEGQRRDPAHPALRLLRQHRHLVTLLLWRPGSVDWKDHQHICGQSAAVTVQADEVHVAES
VMEKVTV

--------------------------------------------------------------
>81834_81834_4_SIGIRR-DEAF1_SIGIRR_chr11_406843_ENST00000431843_DEAF1_chr11_644654_ENST00000382409_length(transcript)=1608nt_BP=1186nt
AAGACACAAGCCAGGTCCCCACCGCGCTTGGCGATGCATCCATAGCAGCCTTGGTGCTGTGGACACTCCCTGGGGCCCAGCGAAGGGGAG
AGTTTGCTCCCAAAGGCGCACCAATGACCAACATTTGCCCCCCGGAGGAAAGAACTGGAACCAGCCTCTGACCTGTCCAGGTGCCCTGTC
CAGCTGACTGCAAGGACAGAGAGGAGTCCTGCCCAGCTCTTGGATCAGTCTGCTGGCCGAGGAGCCCGGTGGAGCCAGGGGTGACCCTGG
AGCCCAGCCTGCCCCGAGGAGGCCCCGGCTCAGAGCCATGCCAGGTGTCTGTGATAGGGCCCCTGACTTCCTCTCCCCGTCTGAAGACCA
GGTGCTGAGGCCTGCCTTGGGCAGCTCAGTGGCTCTGAACTGCACGGCTTGGGTAGTCTCTGGGCCCCACTGCTCCCTGCCTTCAGTCCA
GTGGCTGAAAGACGGGCTTCCATTGGGAATTGGGGGCCACTACAGCCTCCACGAGTACTCCTGGGTCAAGGCCAACCTGTCAGAGGTGCT
TGTGTCCAGTGTCCTGGGGGTCAACGTGACCAGCACTGAAGTCTATGGGGCCTTCACCTGCTCCATCCAGAACATCAGCTTCTCCTCCTT
CACTCTTCAGAGAGCTGGCCCTACAAGCCACGTGGCTGCGGTGCTGGCCTCCCTCCTGGTCCTGCTGGCCCTGCTGCTGGCCGCCCTGCT
CTATGTCAAGTGCCGTCTCAACGTGCTGCTCTGGTACCAGGACGCGTATGGGGAGGTGGAGATAAACGACGGGAAGCTCTACGACGCCTA
CGTCTCCTACAGCGACTGCCCCGAGGACCGCAAGTTCGTGAACTTCATCCTAAAGCCGCAGCTGGAGCGGCGTCGGGGCTACAAGCTCTT
CCTGGACGACCGCGACCTCCTGCCGCGCGCTGAGCCCTCCGCCGACCTCTTGGTGAACCTGAGCCGCTGCCGACGCCTCATCGTGGTGCT
TTCGGACGCCTTCCTGAGCCGGGCCTGGTGCAGCCACAGCTTCCGGGAGGGCCTGTGCCGGCTGCTGGAGCTCACCCGCAGACCCATCTT
CATCACCTTCGAGGGCCAGAGGCGCGACCCCGCGCACCCGGCGCTCCGCCTGCTGCGCCAGCACCGCCACCTGGTGACCTTGCTGCTCTG
GAGGCCCGGCTCCGTGGACTGGAAGGATCACCAGCACATATGCGGCCAGTCAGCAGCTGTCACCGTCCAGGCAGACGAAGTCCACGTGGC
TGAAAGCGTGATGGAGAAGGTGACCGTGTGAGGCTCCATCGGCCGCCCTGGGAGCTGGGGCCCCTCGCACTCCTGTGAGGCTTTTGCAGG
TCGAAGGCCCCCCTGAGGACTCTGGGGGGACGTTGAGAAGAGGGGTGTGGGAAGGTAAAGAAACTTGCTGGACAAGTCATTAACACACTT
TAAGCGAATGGTGCCCTGGGAAGCGCACTCCCCCTGCCCGGGCCCCCTGCCCGCTCGCGGACAGATTTTTTATCCCTGGGATCATGAGCG
TCCGGTCTTGCCCACAGGGCCTGTGCTGCGACGCACATACATACGTGTTGTGTCTGTCAATAAAGTGTAAATAAGGTC

>81834_81834_4_SIGIRR-DEAF1_SIGIRR_chr11_406843_ENST00000431843_DEAF1_chr11_644654_ENST00000382409_length(amino acids)=367AA_BP=333
MQGQRGVLPSSWISLLAEEPGGARGDPGAQPAPRRPRLRAMPGVCDRAPDFLSPSEDQVLRPALGSSVALNCTAWVVSGPHCSLPSVQWL
KDGLPLGIGGHYSLHEYSWVKANLSEVLVSSVLGVNVTSTEVYGAFTCSIQNISFSSFTLQRAGPTSHVAAVLASLLVLLALLLAALLYV
KCRLNVLLWYQDAYGEVEINDGKLYDAYVSYSDCPEDRKFVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVVLSD
AFLSRAWCSHSFREGLCRLLELTRRPIFITFEGQRRDPAHPALRLLRQHRHLVTLLLWRPGSVDWKDHQHICGQSAAVTVQADEVHVAES
VMEKVTV

--------------------------------------------------------------
>81834_81834_5_SIGIRR-DEAF1_SIGIRR_chr11_406843_ENST00000531205_DEAF1_chr11_644654_ENST00000338675_length(transcript)=1404nt_BP=982nt
AGTCCTGCCCAGCTCTTGGATCAGTCTGCTGGCCGAGGAGCCCGGTGGAGCCAGGGGTGACCCTGGAGCCCAGCCTGCCCCGAGGAGGCC
CCGGCTCAGAGCCATGCCAGGTGTCTGTGATAGGGCCCCTGACTTCCTCTCCCCGTCTGAAGACCAGGTGCTGAGGCCTGCCTTGGGCAG
CTCAGTGGCTCTGAACTGCACGGCTTGGGTAGTCTCTGGGCCCCACTGCTCCCTGCCTTCAGTCCAGTGGCTGAAAGACGGGCTTCCATT
GGGAATTGGGGGCCACTACAGCCTCCACGAGTACTCCTGGGTCAAGGCCAACCTGTCAGAGGTGCTTGTGTCCAGTGTCCTGGGGGTCAA
CGTGACCAGCACTGAAGTCTATGGGGCCTTCACCTGCTCCATCCAGAACATCAGCTTCTCCTCCTTCACTCTTCAGAGAGCTGGCCCTAC
AAGCCACGTGGCTGCGGTGCTGGCCTCCCTCCTGGTCCTGCTGGCCCTGCTGCTGGCCGCCCTGCTCTATGTCAAGTGCCGTCTCAACGT
GCTGCTCTGGTACCAGGACGCGTATGGGGAGGTGGAGATAAACGACGGGAAGCTCTACGACGCCTACGTCTCCTACAGCGACTGCCCCGA
GGACCGCAAGTTCGTGAACTTCATCCTAAAGCCGCAGCTGGAGCGGCGTCGGGGCTACAAGCTCTTCCTGGACGACCGCGACCTCCTGCC
GCGCGCTGAGCCCTCCGCCGACCTCTTGGTGAACCTGAGCCGCTGCCGACGCCTCATCGTGGTGCTTTCGGACGCCTTCCTGAGCCGGGC
CTGGTGCAGCCACAGCTTCCGGGAGGGCCTGTGCCGGCTGCTGGAGCTCACCCGCAGACCCATCTTCATCACCTTCGAGGGCCAGAGGCG
CGACCCCGCGCACCCGGCGCTCCGCCTGCTGCGCCAGCACCGCCACCTGGTGACCTTGCTGCTCTGGAGGCCCGGCTCCGTGGACTGGAA
GGATCACCAGCACATATGCGGCCAGTCAGCAGCTGTCACCGTCCAGGCAGACGAAGTCCACGTGGCTGAAAGCGTGATGGAGAAGGTGAC
CGTGTGAGGCTCCATCGGCCGCCCTGGGAGCTGGGGCCCCTCGCACTCCTGTGAGGCTTTTGCAGGTCGAAGGCCCCCCTGAGGACTCTG
GGGGGACGTTGAGAAGAGGGGTGTGGGAAGGTAAAGAAACTTGCTGGACAAGTCATTAACACACTTTAAGCGAATGGTGCCCTGGGAAGC
GCACTCCCCCTGCCCGGGCCCCCTGCCCGCTCGCGGACAGATTTTTTATCCCTGGGATCATGAGCGTCCGGTCTTGCCCACAGGGCCTGT
GCTGCGACGCACATACATACGTGTTGTGTCTGTCAATAAAGTGTAAATAAGGTC

>81834_81834_5_SIGIRR-DEAF1_SIGIRR_chr11_406843_ENST00000531205_DEAF1_chr11_644654_ENST00000338675_length(amino acids)=360AA_BP=326
MPSSWISLLAEEPGGARGDPGAQPAPRRPRLRAMPGVCDRAPDFLSPSEDQVLRPALGSSVALNCTAWVVSGPHCSLPSVQWLKDGLPLG
IGGHYSLHEYSWVKANLSEVLVSSVLGVNVTSTEVYGAFTCSIQNISFSSFTLQRAGPTSHVAAVLASLLVLLALLLAALLYVKCRLNVL
LWYQDAYGEVEINDGKLYDAYVSYSDCPEDRKFVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVVLSDAFLSRAW
CSHSFREGLCRLLELTRRPIFITFEGQRRDPAHPALRLLRQHRHLVTLLLWRPGSVDWKDHQHICGQSAAVTVQADEVHVAESVMEKVTV


--------------------------------------------------------------
>81834_81834_6_SIGIRR-DEAF1_SIGIRR_chr11_407061_ENST00000382520_DEAF1_chr11_644654_ENST00000382409_length(transcript)=1335nt_BP=913nt
GGTGAGTGGCGGTCGCCATCAGACCCGCGAAGCCTCTGACCTGTCCAGGTGCCCTGTCCAGCTGACTGCAAGGACAGAGAGGAGTCCTGC
CCAGCTCTTGGATCAGTCTGCTGGCCGAGGAGCCCGGTGGAGCCAGGGGTGACCCTGGAGCCCAGCCTGCCCCGAGGAGGCCCCGGCTCA
GAGCCATGCCAGGTGTCTGTGATAGGGCCCCTGACTTCCTCTCCCCGTCTGAAGACCAGGTGCTGAGGCCTGCCTTGGGCAGCTCAGTGG
CTCTGAACTGCACGGCTTGGGTAGTCTCTGGGCCCCACTGCTCCCTGCCTTCAGTCCAGTGGCTGAAAGACGGGCTTCCATTGGGAATTG
GGGGCCACTACAGCCTCCACGAGTACTCCTGGGTCAAGGCCAACCTGTCAGAGGTGCTTGTGTCCAGTGTCCTGGGGGTCAACGTGACCA
GCACTGAAGTCTATGGGGCCTTCACCTGCTCCATCCAGAACATCAGCTTCTCCTCCTTCACTCTTCAGAGAGCTGGCCCTACAAGCCACG
TGGCTGCGGTGCTGGCCTCCCTCCTGGTCCTGCTGGCCCTGCTGCTGGCCGCCCTGCTCTATGTCAAGTGCCGTCTCAACGTGCTGCTCT
GGTACCAGGACGCGTATGGGGAGGTGGAGATAAACGACGGGAAGCTCTACGACGCCTACGTCTCCTACAGCGACTGCCCCGAGGACCGCA
AGTTCGTGAACTTCATCCTAAAGCCGCAGCTGGAGCGGCGTCGGGGCTACAAGCTCTTCCTGGACGACCGCGACCTCCTGCCGCGCGCTG
AGCCCTCCGCCGACCTCTTGGTGAACCTGAGCCGCTGCCGACGCCTCATCGTGGTGCTTTCGGACGCCTTCCTGAGCCGGGCCTGGTGCA
GCCACAGCTTCCGGACTGGAAGGATCACCAGCACATATGCGGCCAGTCAGCAGCTGTCACCGTCCAGGCAGACGAAGTCCACGTGGCTGA
AAGCGTGATGGAGAAGGTGACCGTGTGAGGCTCCATCGGCCGCCCTGGGAGCTGGGGCCCCTCGCACTCCTGTGAGGCTTTTGCAGGTCG
AAGGCCCCCCTGAGGACTCTGGGGGGACGTTGAGAAGAGGGGTGTGGGAAGGTAAAGAAACTTGCTGGACAAGTCATTAACACACTTTAA
GCGAATGGTGCCCTGGGAAGCGCACTCCCCCTGCCCGGGCCCCCTGCCCGCTCGCGGACAGATTTTTTATCCCTGGGATCATGAGCGTCC
GGTCTTGCCCACAGGGCCTGTGCTGCGACGCACATACATACGTGTTGTGTCTGTCAATAAAGTGTAAATAAGGTC

>81834_81834_6_SIGIRR-DEAF1_SIGIRR_chr11_407061_ENST00000382520_DEAF1_chr11_644654_ENST00000382409_length(amino acids)=310AA_BP=282
MQGQRGVLPSSWISLLAEEPGGARGDPGAQPAPRRPRLRAMPGVCDRAPDFLSPSEDQVLRPALGSSVALNCTAWVVSGPHCSLPSVQWL
KDGLPLGIGGHYSLHEYSWVKANLSEVLVSSVLGVNVTSTEVYGAFTCSIQNISFSSFTLQRAGPTSHVAAVLASLLVLLALLLAALLYV
KCRLNVLLWYQDAYGEVEINDGKLYDAYVSYSDCPEDRKFVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVVLSD
AFLSRAWCSHSFRTGRITSTYAASQQLSPSRQTKSTWLKA

--------------------------------------------------------------
>81834_81834_7_SIGIRR-DEAF1_SIGIRR_chr11_407061_ENST00000397632_DEAF1_chr11_644654_ENST00000382409_length(transcript)=1335nt_BP=913nt
GGTGAGTGGCGGTCGCCATCAGACCCGCGAAGCCTCTGACCTGTCCAGGTGCCCTGTCCAGCTGACTGCAAGGACAGAGAGGAGTCCTGC
CCAGCTCTTGGATCAGTCTGCTGGCCGAGGAGCCCGGTGGAGCCAGGGGTGACCCTGGAGCCCAGCCTGCCCCGAGGAGGCCCCGGCTCA
GAGCCATGCCAGGTGTCTGTGATAGGGCCCCTGACTTCCTCTCCCCGTCTGAAGACCAGGTGCTGAGGCCTGCCTTGGGCAGCTCAGTGG
CTCTGAACTGCACGGCTTGGGTAGTCTCTGGGCCCCACTGCTCCCTGCCTTCAGTCCAGTGGCTGAAAGACGGGCTTCCATTGGGAATTG
GGGGCCACTACAGCCTCCACGAGTACTCCTGGGTCAAGGCCAACCTGTCAGAGGTGCTTGTGTCCAGTGTCCTGGGGGTCAACGTGACCA
GCACTGAAGTCTATGGGGCCTTCACCTGCTCCATCCAGAACATCAGCTTCTCCTCCTTCACTCTTCAGAGAGCTGGCCCTACAAGCCACG
TGGCTGCGGTGCTGGCCTCCCTCCTGGTCCTGCTGGCCCTGCTGCTGGCCGCCCTGCTCTATGTCAAGTGCCGTCTCAACGTGCTGCTCT
GGTACCAGGACGCGTATGGGGAGGTGGAGATAAACGACGGGAAGCTCTACGACGCCTACGTCTCCTACAGCGACTGCCCCGAGGACCGCA
AGTTCGTGAACTTCATCCTAAAGCCGCAGCTGGAGCGGCGTCGGGGCTACAAGCTCTTCCTGGACGACCGCGACCTCCTGCCGCGCGCTG
AGCCCTCCGCCGACCTCTTGGTGAACCTGAGCCGCTGCCGACGCCTCATCGTGGTGCTTTCGGACGCCTTCCTGAGCCGGGCCTGGTGCA
GCCACAGCTTCCGGACTGGAAGGATCACCAGCACATATGCGGCCAGTCAGCAGCTGTCACCGTCCAGGCAGACGAAGTCCACGTGGCTGA
AAGCGTGATGGAGAAGGTGACCGTGTGAGGCTCCATCGGCCGCCCTGGGAGCTGGGGCCCCTCGCACTCCTGTGAGGCTTTTGCAGGTCG
AAGGCCCCCCTGAGGACTCTGGGGGGACGTTGAGAAGAGGGGTGTGGGAAGGTAAAGAAACTTGCTGGACAAGTCATTAACACACTTTAA
GCGAATGGTGCCCTGGGAAGCGCACTCCCCCTGCCCGGGCCCCCTGCCCGCTCGCGGACAGATTTTTTATCCCTGGGATCATGAGCGTCC
GGTCTTGCCCACAGGGCCTGTGCTGCGACGCACATACATACGTGTTGTGTCTGTCAATAAAGTGTAAATAAGGTC

>81834_81834_7_SIGIRR-DEAF1_SIGIRR_chr11_407061_ENST00000397632_DEAF1_chr11_644654_ENST00000382409_length(amino acids)=310AA_BP=282
MQGQRGVLPSSWISLLAEEPGGARGDPGAQPAPRRPRLRAMPGVCDRAPDFLSPSEDQVLRPALGSSVALNCTAWVVSGPHCSLPSVQWL
KDGLPLGIGGHYSLHEYSWVKANLSEVLVSSVLGVNVTSTEVYGAFTCSIQNISFSSFTLQRAGPTSHVAAVLASLLVLLALLLAALLYV
KCRLNVLLWYQDAYGEVEINDGKLYDAYVSYSDCPEDRKFVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVVLSD
AFLSRAWCSHSFRTGRITSTYAASQQLSPSRQTKSTWLKA

--------------------------------------------------------------
>81834_81834_8_SIGIRR-DEAF1_SIGIRR_chr11_407061_ENST00000531205_DEAF1_chr11_644654_ENST00000382409_length(transcript)=1253nt_BP=831nt
AGTCCTGCCCAGCTCTTGGATCAGTCTGCTGGCCGAGGAGCCCGGTGGAGCCAGGGGTGACCCTGGAGCCCAGCCTGCCCCGAGGAGGCC
CCGGCTCAGAGCCATGCCAGGTGTCTGTGATAGGGCCCCTGACTTCCTCTCCCCGTCTGAAGACCAGGTGCTGAGGCCTGCCTTGGGCAG
CTCAGTGGCTCTGAACTGCACGGCTTGGGTAGTCTCTGGGCCCCACTGCTCCCTGCCTTCAGTCCAGTGGCTGAAAGACGGGCTTCCATT
GGGAATTGGGGGCCACTACAGCCTCCACGAGTACTCCTGGGTCAAGGCCAACCTGTCAGAGGTGCTTGTGTCCAGTGTCCTGGGGGTCAA
CGTGACCAGCACTGAAGTCTATGGGGCCTTCACCTGCTCCATCCAGAACATCAGCTTCTCCTCCTTCACTCTTCAGAGAGCTGGCCCTAC
AAGCCACGTGGCTGCGGTGCTGGCCTCCCTCCTGGTCCTGCTGGCCCTGCTGCTGGCCGCCCTGCTCTATGTCAAGTGCCGTCTCAACGT
GCTGCTCTGGTACCAGGACGCGTATGGGGAGGTGGAGATAAACGACGGGAAGCTCTACGACGCCTACGTCTCCTACAGCGACTGCCCCGA
GGACCGCAAGTTCGTGAACTTCATCCTAAAGCCGCAGCTGGAGCGGCGTCGGGGCTACAAGCTCTTCCTGGACGACCGCGACCTCCTGCC
GCGCGCTGAGCCCTCCGCCGACCTCTTGGTGAACCTGAGCCGCTGCCGACGCCTCATCGTGGTGCTTTCGGACGCCTTCCTGAGCCGGGC
CTGGTGCAGCCACAGCTTCCGGACTGGAAGGATCACCAGCACATATGCGGCCAGTCAGCAGCTGTCACCGTCCAGGCAGACGAAGTCCAC
GTGGCTGAAAGCGTGATGGAGAAGGTGACCGTGTGAGGCTCCATCGGCCGCCCTGGGAGCTGGGGCCCCTCGCACTCCTGTGAGGCTTTT
GCAGGTCGAAGGCCCCCCTGAGGACTCTGGGGGGACGTTGAGAAGAGGGGTGTGGGAAGGTAAAGAAACTTGCTGGACAAGTCATTAACA
CACTTTAAGCGAATGGTGCCCTGGGAAGCGCACTCCCCCTGCCCGGGCCCCCTGCCCGCTCGCGGACAGATTTTTTATCCCTGGGATCAT
GAGCGTCCGGTCTTGCCCACAGGGCCTGTGCTGCGACGCACATACATACGTGTTGTGTCTGTCAATAAAGTGTAAATAAGGTC

>81834_81834_8_SIGIRR-DEAF1_SIGIRR_chr11_407061_ENST00000531205_DEAF1_chr11_644654_ENST00000382409_length(amino acids)=303AA_BP=275
MPSSWISLLAEEPGGARGDPGAQPAPRRPRLRAMPGVCDRAPDFLSPSEDQVLRPALGSSVALNCTAWVVSGPHCSLPSVQWLKDGLPLG
IGGHYSLHEYSWVKANLSEVLVSSVLGVNVTSTEVYGAFTCSIQNISFSSFTLQRAGPTSHVAAVLASLLVLLALLLAALLYVKCRLNVL
LWYQDAYGEVEINDGKLYDAYVSYSDCPEDRKFVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVVLSDAFLSRAW
CSHSFRTGRITSTYAASQQLSPSRQTKSTWLKA

--------------------------------------------------------------
>81834_81834_9_SIGIRR-DEAF1_SIGIRR_chr11_407062_ENST00000382520_DEAF1_chr11_644654_ENST00000382409_length(transcript)=1335nt_BP=913nt
GGTGAGTGGCGGTCGCCATCAGACCCGCGAAGCCTCTGACCTGTCCAGGTGCCCTGTCCAGCTGACTGCAAGGACAGAGAGGAGTCCTGC
CCAGCTCTTGGATCAGTCTGCTGGCCGAGGAGCCCGGTGGAGCCAGGGGTGACCCTGGAGCCCAGCCTGCCCCGAGGAGGCCCCGGCTCA
GAGCCATGCCAGGTGTCTGTGATAGGGCCCCTGACTTCCTCTCCCCGTCTGAAGACCAGGTGCTGAGGCCTGCCTTGGGCAGCTCAGTGG
CTCTGAACTGCACGGCTTGGGTAGTCTCTGGGCCCCACTGCTCCCTGCCTTCAGTCCAGTGGCTGAAAGACGGGCTTCCATTGGGAATTG
GGGGCCACTACAGCCTCCACGAGTACTCCTGGGTCAAGGCCAACCTGTCAGAGGTGCTTGTGTCCAGTGTCCTGGGGGTCAACGTGACCA
GCACTGAAGTCTATGGGGCCTTCACCTGCTCCATCCAGAACATCAGCTTCTCCTCCTTCACTCTTCAGAGAGCTGGCCCTACAAGCCACG
TGGCTGCGGTGCTGGCCTCCCTCCTGGTCCTGCTGGCCCTGCTGCTGGCCGCCCTGCTCTATGTCAAGTGCCGTCTCAACGTGCTGCTCT
GGTACCAGGACGCGTATGGGGAGGTGGAGATAAACGACGGGAAGCTCTACGACGCCTACGTCTCCTACAGCGACTGCCCCGAGGACCGCA
AGTTCGTGAACTTCATCCTAAAGCCGCAGCTGGAGCGGCGTCGGGGCTACAAGCTCTTCCTGGACGACCGCGACCTCCTGCCGCGCGCTG
AGCCCTCCGCCGACCTCTTGGTGAACCTGAGCCGCTGCCGACGCCTCATCGTGGTGCTTTCGGACGCCTTCCTGAGCCGGGCCTGGTGCA
GCCACAGCTTCCGGACTGGAAGGATCACCAGCACATATGCGGCCAGTCAGCAGCTGTCACCGTCCAGGCAGACGAAGTCCACGTGGCTGA
AAGCGTGATGGAGAAGGTGACCGTGTGAGGCTCCATCGGCCGCCCTGGGAGCTGGGGCCCCTCGCACTCCTGTGAGGCTTTTGCAGGTCG
AAGGCCCCCCTGAGGACTCTGGGGGGACGTTGAGAAGAGGGGTGTGGGAAGGTAAAGAAACTTGCTGGACAAGTCATTAACACACTTTAA
GCGAATGGTGCCCTGGGAAGCGCACTCCCCCTGCCCGGGCCCCCTGCCCGCTCGCGGACAGATTTTTTATCCCTGGGATCATGAGCGTCC
GGTCTTGCCCACAGGGCCTGTGCTGCGACGCACATACATACGTGTTGTGTCTGTCAATAAAGTGTAAATAAGGTC

>81834_81834_9_SIGIRR-DEAF1_SIGIRR_chr11_407062_ENST00000382520_DEAF1_chr11_644654_ENST00000382409_length(amino acids)=310AA_BP=282
MQGQRGVLPSSWISLLAEEPGGARGDPGAQPAPRRPRLRAMPGVCDRAPDFLSPSEDQVLRPALGSSVALNCTAWVVSGPHCSLPSVQWL
KDGLPLGIGGHYSLHEYSWVKANLSEVLVSSVLGVNVTSTEVYGAFTCSIQNISFSSFTLQRAGPTSHVAAVLASLLVLLALLLAALLYV
KCRLNVLLWYQDAYGEVEINDGKLYDAYVSYSDCPEDRKFVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVVLSD
AFLSRAWCSHSFRTGRITSTYAASQQLSPSRQTKSTWLKA

--------------------------------------------------------------
>81834_81834_10_SIGIRR-DEAF1_SIGIRR_chr11_407062_ENST00000397632_DEAF1_chr11_644654_ENST00000382409_length(transcript)=1335nt_BP=913nt
GGTGAGTGGCGGTCGCCATCAGACCCGCGAAGCCTCTGACCTGTCCAGGTGCCCTGTCCAGCTGACTGCAAGGACAGAGAGGAGTCCTGC
CCAGCTCTTGGATCAGTCTGCTGGCCGAGGAGCCCGGTGGAGCCAGGGGTGACCCTGGAGCCCAGCCTGCCCCGAGGAGGCCCCGGCTCA
GAGCCATGCCAGGTGTCTGTGATAGGGCCCCTGACTTCCTCTCCCCGTCTGAAGACCAGGTGCTGAGGCCTGCCTTGGGCAGCTCAGTGG
CTCTGAACTGCACGGCTTGGGTAGTCTCTGGGCCCCACTGCTCCCTGCCTTCAGTCCAGTGGCTGAAAGACGGGCTTCCATTGGGAATTG
GGGGCCACTACAGCCTCCACGAGTACTCCTGGGTCAAGGCCAACCTGTCAGAGGTGCTTGTGTCCAGTGTCCTGGGGGTCAACGTGACCA
GCACTGAAGTCTATGGGGCCTTCACCTGCTCCATCCAGAACATCAGCTTCTCCTCCTTCACTCTTCAGAGAGCTGGCCCTACAAGCCACG
TGGCTGCGGTGCTGGCCTCCCTCCTGGTCCTGCTGGCCCTGCTGCTGGCCGCCCTGCTCTATGTCAAGTGCCGTCTCAACGTGCTGCTCT
GGTACCAGGACGCGTATGGGGAGGTGGAGATAAACGACGGGAAGCTCTACGACGCCTACGTCTCCTACAGCGACTGCCCCGAGGACCGCA
AGTTCGTGAACTTCATCCTAAAGCCGCAGCTGGAGCGGCGTCGGGGCTACAAGCTCTTCCTGGACGACCGCGACCTCCTGCCGCGCGCTG
AGCCCTCCGCCGACCTCTTGGTGAACCTGAGCCGCTGCCGACGCCTCATCGTGGTGCTTTCGGACGCCTTCCTGAGCCGGGCCTGGTGCA
GCCACAGCTTCCGGACTGGAAGGATCACCAGCACATATGCGGCCAGTCAGCAGCTGTCACCGTCCAGGCAGACGAAGTCCACGTGGCTGA
AAGCGTGATGGAGAAGGTGACCGTGTGAGGCTCCATCGGCCGCCCTGGGAGCTGGGGCCCCTCGCACTCCTGTGAGGCTTTTGCAGGTCG
AAGGCCCCCCTGAGGACTCTGGGGGGACGTTGAGAAGAGGGGTGTGGGAAGGTAAAGAAACTTGCTGGACAAGTCATTAACACACTTTAA
GCGAATGGTGCCCTGGGAAGCGCACTCCCCCTGCCCGGGCCCCCTGCCCGCTCGCGGACAGATTTTTTATCCCTGGGATCATGAGCGTCC
GGTCTTGCCCACAGGGCCTGTGCTGCGACGCACATACATACGTGTTGTGTCTGTCAATAAAGTGTAAATAAGGTC

>81834_81834_10_SIGIRR-DEAF1_SIGIRR_chr11_407062_ENST00000397632_DEAF1_chr11_644654_ENST00000382409_length(amino acids)=310AA_BP=282
MQGQRGVLPSSWISLLAEEPGGARGDPGAQPAPRRPRLRAMPGVCDRAPDFLSPSEDQVLRPALGSSVALNCTAWVVSGPHCSLPSVQWL
KDGLPLGIGGHYSLHEYSWVKANLSEVLVSSVLGVNVTSTEVYGAFTCSIQNISFSSFTLQRAGPTSHVAAVLASLLVLLALLLAALLYV
KCRLNVLLWYQDAYGEVEINDGKLYDAYVSYSDCPEDRKFVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVVLSD
AFLSRAWCSHSFRTGRITSTYAASQQLSPSRQTKSTWLKA

--------------------------------------------------------------
>81834_81834_11_SIGIRR-DEAF1_SIGIRR_chr11_407062_ENST00000531205_DEAF1_chr11_644654_ENST00000382409_length(transcript)=1253nt_BP=831nt
AGTCCTGCCCAGCTCTTGGATCAGTCTGCTGGCCGAGGAGCCCGGTGGAGCCAGGGGTGACCCTGGAGCCCAGCCTGCCCCGAGGAGGCC
CCGGCTCAGAGCCATGCCAGGTGTCTGTGATAGGGCCCCTGACTTCCTCTCCCCGTCTGAAGACCAGGTGCTGAGGCCTGCCTTGGGCAG
CTCAGTGGCTCTGAACTGCACGGCTTGGGTAGTCTCTGGGCCCCACTGCTCCCTGCCTTCAGTCCAGTGGCTGAAAGACGGGCTTCCATT
GGGAATTGGGGGCCACTACAGCCTCCACGAGTACTCCTGGGTCAAGGCCAACCTGTCAGAGGTGCTTGTGTCCAGTGTCCTGGGGGTCAA
CGTGACCAGCACTGAAGTCTATGGGGCCTTCACCTGCTCCATCCAGAACATCAGCTTCTCCTCCTTCACTCTTCAGAGAGCTGGCCCTAC
AAGCCACGTGGCTGCGGTGCTGGCCTCCCTCCTGGTCCTGCTGGCCCTGCTGCTGGCCGCCCTGCTCTATGTCAAGTGCCGTCTCAACGT
GCTGCTCTGGTACCAGGACGCGTATGGGGAGGTGGAGATAAACGACGGGAAGCTCTACGACGCCTACGTCTCCTACAGCGACTGCCCCGA
GGACCGCAAGTTCGTGAACTTCATCCTAAAGCCGCAGCTGGAGCGGCGTCGGGGCTACAAGCTCTTCCTGGACGACCGCGACCTCCTGCC
GCGCGCTGAGCCCTCCGCCGACCTCTTGGTGAACCTGAGCCGCTGCCGACGCCTCATCGTGGTGCTTTCGGACGCCTTCCTGAGCCGGGC
CTGGTGCAGCCACAGCTTCCGGACTGGAAGGATCACCAGCACATATGCGGCCAGTCAGCAGCTGTCACCGTCCAGGCAGACGAAGTCCAC
GTGGCTGAAAGCGTGATGGAGAAGGTGACCGTGTGAGGCTCCATCGGCCGCCCTGGGAGCTGGGGCCCCTCGCACTCCTGTGAGGCTTTT
GCAGGTCGAAGGCCCCCCTGAGGACTCTGGGGGGACGTTGAGAAGAGGGGTGTGGGAAGGTAAAGAAACTTGCTGGACAAGTCATTAACA
CACTTTAAGCGAATGGTGCCCTGGGAAGCGCACTCCCCCTGCCCGGGCCCCCTGCCCGCTCGCGGACAGATTTTTTATCCCTGGGATCAT
GAGCGTCCGGTCTTGCCCACAGGGCCTGTGCTGCGACGCACATACATACGTGTTGTGTCTGTCAATAAAGTGTAAATAAGGTC

>81834_81834_11_SIGIRR-DEAF1_SIGIRR_chr11_407062_ENST00000531205_DEAF1_chr11_644654_ENST00000382409_length(amino acids)=303AA_BP=275
MPSSWISLLAEEPGGARGDPGAQPAPRRPRLRAMPGVCDRAPDFLSPSEDQVLRPALGSSVALNCTAWVVSGPHCSLPSVQWLKDGLPLG
IGGHYSLHEYSWVKANLSEVLVSSVLGVNVTSTEVYGAFTCSIQNISFSSFTLQRAGPTSHVAAVLASLLVLLALLLAALLYVKCRLNVL
LWYQDAYGEVEINDGKLYDAYVSYSDCPEDRKFVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVVLSDAFLSRAW
CSHSFRTGRITSTYAASQQLSPSRQTKSTWLKA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SIGIRR-DEAF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneDEAF1chr11:406843chr11:644654ENST00000338675911403_478456.0491.0LMO4
TgeneDEAF1chr11:406843chr11:644654ENST000003824091012403_478531.0566.0LMO4
TgeneDEAF1chr11:407061chr11:644654ENST00000338675911403_478456.0491.0LMO4
TgeneDEAF1chr11:407061chr11:644654ENST000003824091012403_478531.0566.0LMO4
TgeneDEAF1chr11:407062chr11:644654ENST00000338675911403_478456.0491.0LMO4
TgeneDEAF1chr11:407062chr11:644654ENST000003824091012403_478531.0566.0LMO4


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SIGIRR-DEAF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SIGIRR-DEAF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0041696Unipolar Depression5PSYGENET
TgeneC1269683Major Depressive Disorder5PSYGENET
TgeneC0011570Mental Depression4PSYGENET
TgeneC0011581Depressive disorder4PSYGENET
TgeneC4014414MENTAL RETARDATION, AUTOSOMAL DOMINANT 243CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC4310683DYSKINESIA, SEIZURES, AND INTELLECTUAL DEVELOPMENTAL DISORDER3CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneC0020796Profound Mental Retardation1CTD_human
TgeneC0025363Mental Retardation, Psychosocial1CTD_human
TgeneC0795864Smith-Magenis syndrome1ORPHANET
TgeneC0917816Mental deficiency1CTD_human
TgeneC3714756Intellectual Disability1CTD_human