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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:TRIM27-ACOX1 (FusionGDB2 ID:HG5987TG51) |
Fusion Gene Summary for TRIM27-ACOX1 |
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Fusion gene information | Fusion gene name: TRIM27-ACOX1 | Fusion gene ID: hg5987tg51 | Hgene | Tgene | Gene symbol | TRIM27 | ACOX1 | Gene ID | 5987 | 51 |
Gene name | tripartite motif containing 27 | acyl-CoA oxidase 1 | |
Synonyms | RFP|RNF76 | ACOX|PALMCOX|SCOX | |
Cytomap | ('TRIM27')('ACOX1') 6p22.1 | 17q25.1 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein RFPRFP transforming proteinRING finger protein 76RING-type E3 ubiquitin transferase TRIM27ret finger proteintripartite motif protein TRIM27tripartite motif-containing protein 27 | peroxisomal acyl-coenzyme A oxidase 1AOXacyl-CoA oxidase 1, palmitoylacyl-CoA oxidase, straight-chainacyl-Coenzyme A oxidase 1, palmitoylpalmitoyl-CoA oxidaseperoxisomal fatty acyl-CoA oxidasestraight-chain acyl-CoA oxidase | |
Modification date | 20200327 | 20200313 | |
UniProtAcc | P14373 | . | |
Ensembl transtripts involved in fusion gene | ENST00000377194, ENST00000377199, ENST00000400720, ENST00000412687, ENST00000417660, ENST00000427689, ENST00000431123, ENST00000435528, ENST00000437160, ENST00000437415, ENST00000452265, ENST00000455861, ENST00000459807, ENST00000468047, ENST00000468364, ENST00000485666, ENST00000491158, ENST00000495323, ENST00000498117, | ||
Fusion gene scores | * DoF score | 5 X 9 X 7=315 | 11 X 11 X 8=968 |
# samples | 9 | 14 | |
** MAII score | log2(9/315*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(14/968*10)=-2.78958022032963 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TRIM27 [Title/Abstract] AND ACOX1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | TRIM27(28872335)-ACOX1(73949673), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | TRIM27-ACOX1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. TRIM27-ACOX1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. TRIM27-ACOX1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TRIM27 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 10976108 |
Hgene | TRIM27 | GO:0006469 | negative regulation of protein kinase activity | 22128329 |
Hgene | TRIM27 | GO:0032897 | negative regulation of viral transcription | 18248090 |
Hgene | TRIM27 | GO:0034314 | Arp2/3 complex-mediated actin nucleation | 23452853 |
Hgene | TRIM27 | GO:0042147 | retrograde transport, endosome to Golgi | 23452853 |
Hgene | TRIM27 | GO:0045087 | innate immune response | 18248090 |
Hgene | TRIM27 | GO:0045814 | negative regulation of gene expression, epigenetic | 10976108 |
Hgene | TRIM27 | GO:0051091 | positive regulation of DNA-binding transcription factor activity | 23077300 |
Tgene | ACOX1 | GO:0006629 | lipid metabolic process | 8117268 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | STAD | TCGA-D7-8574-01A | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
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Fusion Gene ORF analysis for TRIM27-ACOX1 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000377194 | ENST00000591857 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
Frame-shift | ENST00000377194 | ENST00000293217 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
Frame-shift | ENST00000377194 | ENST00000301608 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
Frame-shift | ENST00000377194 | ENST00000537812 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000377199 | ENST00000293217 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000377199 | ENST00000301608 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000377199 | ENST00000537812 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000400720 | ENST00000293217 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000400720 | ENST00000301608 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000400720 | ENST00000537812 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000412687 | ENST00000293217 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000412687 | ENST00000301608 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000412687 | ENST00000537812 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000417660 | ENST00000293217 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000417660 | ENST00000301608 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000417660 | ENST00000537812 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000427689 | ENST00000293217 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000427689 | ENST00000301608 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000427689 | ENST00000537812 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000431123 | ENST00000293217 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000431123 | ENST00000301608 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000431123 | ENST00000537812 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000435528 | ENST00000293217 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000435528 | ENST00000301608 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000435528 | ENST00000537812 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000437160 | ENST00000293217 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000437160 | ENST00000301608 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000437160 | ENST00000537812 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000437415 | ENST00000293217 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000437415 | ENST00000301608 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000437415 | ENST00000537812 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000452265 | ENST00000293217 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000452265 | ENST00000301608 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000452265 | ENST00000537812 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000455861 | ENST00000293217 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000455861 | ENST00000301608 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000455861 | ENST00000537812 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000459807 | ENST00000293217 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000459807 | ENST00000301608 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000459807 | ENST00000537812 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000468047 | ENST00000293217 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000468047 | ENST00000301608 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000468047 | ENST00000537812 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000468364 | ENST00000293217 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000468364 | ENST00000301608 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000468364 | ENST00000537812 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000485666 | ENST00000293217 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000485666 | ENST00000301608 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000485666 | ENST00000537812 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000491158 | ENST00000293217 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000491158 | ENST00000301608 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000491158 | ENST00000537812 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000495323 | ENST00000293217 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000495323 | ENST00000301608 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000495323 | ENST00000537812 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000498117 | ENST00000293217 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000498117 | ENST00000301608 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-3CDS | ENST00000498117 | ENST00000537812 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-intron | ENST00000377199 | ENST00000591857 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-intron | ENST00000400720 | ENST00000591857 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-intron | ENST00000412687 | ENST00000591857 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-intron | ENST00000417660 | ENST00000591857 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-intron | ENST00000427689 | ENST00000591857 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-intron | ENST00000431123 | ENST00000591857 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-intron | ENST00000435528 | ENST00000591857 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-intron | ENST00000437160 | ENST00000591857 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-intron | ENST00000437415 | ENST00000591857 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-intron | ENST00000452265 | ENST00000591857 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-intron | ENST00000455861 | ENST00000591857 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-intron | ENST00000459807 | ENST00000591857 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-intron | ENST00000468047 | ENST00000591857 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-intron | ENST00000468364 | ENST00000591857 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-intron | ENST00000485666 | ENST00000591857 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-intron | ENST00000491158 | ENST00000591857 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-intron | ENST00000495323 | ENST00000591857 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
intron-intron | ENST00000498117 | ENST00000591857 | TRIM27 | chr6 | 28872335 | - | ACOX1 | chr17 | 73949673 | - |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for TRIM27-ACOX1 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for TRIM27-ACOX1 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:28872335/:73949673) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
TRIM27 | . |
FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA. {ECO:0000269|PubMed:10976108, ECO:0000269|PubMed:12807881, ECO:0000269|PubMed:22128329, ECO:0000269|PubMed:23452853}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for TRIM27-ACOX1 |
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Fusion Gene PPI Analysis for TRIM27-ACOX1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for TRIM27-ACOX1 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for TRIM27-ACOX1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TRIM27 | C0238463 | Papillary thyroid carcinoma | 2 | ORPHANET |
Tgene | C1849678 | Peroxisomal ACYL-COA oxidase deficiency | 7 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT | |
Tgene | C2239176 | Liver carcinoma | 2 | CTD_human | |
Tgene | C0002152 | Alloxan Diabetes | 1 | CTD_human | |
Tgene | C0011853 | Diabetes Mellitus, Experimental | 1 | CTD_human | |
Tgene | C0038433 | Streptozotocin Diabetes | 1 | CTD_human |