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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BCL6-SRSF7 (FusionGDB2 ID:HG604TG6432)

Fusion Gene Summary for BCL6-SRSF7

check button Fusion gene summary
Fusion gene informationFusion gene name: BCL6-SRSF7
Fusion gene ID: hg604tg6432
HgeneTgene
Gene symbol

BCL6

SRSF7

Gene ID

604

6432

Gene nameBCL6 transcription repressorserine and arginine rich splicing factor 7
SynonymsBCL5|BCL6A|LAZ3|ZBTB27|ZNF519G8|AAG3|SFRS7
Cytomap('BCL6')('SRSF7')

3q27.3

2p22.1

Type of geneprotein-codingprotein-coding
DescriptionB-cell lymphoma 6 proteinB cell CLL/lymphoma 6B-cell lymphoma 5 proteinB-cell lymphoma 6 protein transcriptBCL-5BCL-6cys-his2 zinc finger transcription factorlymphoma-associated zinc finger gene on chromosome 3protein LAZ-3zinc finger and BTB domserine/arginine-rich splicing factor 7SR splicing factor 7aging-associated protein 3splicing factor 9G8splicing factor, arginine/serine-rich 7, 35kDa
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000232014, ENST00000406870, 
ENST00000450123, ENST00000496823, 
Fusion gene scores* DoF score15 X 9 X 4=54010 X 5 X 7=350
# samples 1610
** MAII scorelog2(16/540*10)=-1.75488750216347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/350*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BCL6 [Title/Abstract] AND SRSF7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBCL6(187446147)-SRSF7(38975795), # samples:1
Anticipated loss of major functional domain due to fusion event.BCL6-SRSF7 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
BCL6-SRSF7 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
BCL6-SRSF7 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
BCL6-SRSF7 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBCL6

GO:0000122

negative regulation of transcription by RNA polymerase II

11929873|15577913

HgeneBCL6

GO:0006974

cellular response to DNA damage stimulus

15577913

HgeneBCL6

GO:0030308

negative regulation of cell growth

10490843

HgeneBCL6

GO:0043065

positive regulation of apoptotic process

10490843

TgeneSRSF7

GO:0008380

RNA splicing

8013463

TgeneSRSF7

GO:0048025

negative regulation of mRNA splicing, via spliceosome

15009664



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L7-A56GBCL6chr3

187446147

-SRSF7chr2

38975795

-


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Fusion Gene ORF analysis for BCL6-SRSF7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000232014ENST00000313117BCL6chr3

187446147

-SRSF7chr2

38975795

-
Frame-shiftENST00000232014ENST00000409276BCL6chr3

187446147

-SRSF7chr2

38975795

-
Frame-shiftENST00000232014ENST00000446327BCL6chr3

187446147

-SRSF7chr2

38975795

-
Frame-shiftENST00000406870ENST00000313117BCL6chr3

187446147

-SRSF7chr2

38975795

-
Frame-shiftENST00000406870ENST00000409276BCL6chr3

187446147

-SRSF7chr2

38975795

-
Frame-shiftENST00000406870ENST00000446327BCL6chr3

187446147

-SRSF7chr2

38975795

-
Frame-shiftENST00000450123ENST00000313117BCL6chr3

187446147

-SRSF7chr2

38975795

-
Frame-shiftENST00000450123ENST00000409276BCL6chr3

187446147

-SRSF7chr2

38975795

-
Frame-shiftENST00000450123ENST00000446327BCL6chr3

187446147

-SRSF7chr2

38975795

-
intron-3CDSENST00000496823ENST00000313117BCL6chr3

187446147

-SRSF7chr2

38975795

-
intron-3CDSENST00000496823ENST00000409276BCL6chr3

187446147

-SRSF7chr2

38975795

-
intron-3CDSENST00000496823ENST00000446327BCL6chr3

187446147

-SRSF7chr2

38975795

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for BCL6-SRSF7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for BCL6-SRSF7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:187446147/:38975795)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for BCL6-SRSF7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for BCL6-SRSF7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BCL6-SRSF7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BCL6-SRSF7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBCL6C0024301Lymphoma, Follicular1ORPHANET
HgeneBCL6C0024302Reticulosarcoma1CTD_human
HgeneBCL6C0024304Lymphoma, Mixed-Cell1CTD_human
HgeneBCL6C0024305Lymphoma, Non-Hodgkin1CGI;CTD_human
HgeneBCL6C0024306Lymphoma, Undifferentiated1CTD_human
HgeneBCL6C0079740High Grade Lymphoma (neoplasm)1CTD_human
HgeneBCL6C0079741Lymphoma, Intermediate-Grade1CTD_human
HgeneBCL6C0079747Low Grade Lymphoma (neoplasm)1CTD_human
HgeneBCL6C0079757Diffuse Mixed-Cell Lymphoma1CTD_human
HgeneBCL6C0079770Lymphoma, Small Noncleaved-Cell1CTD_human
HgeneBCL6C0079772T-Cell Lymphoma1CTD_human
HgeneBCL6C1292754Mediastinal (Thymic) Large B-Cell Lymphoma1ORPHANET
HgeneBCL6C3714542Lymphoma, Diffuse1CTD_human
HgeneBCL6C4721532Lymphoma, Non-Hodgkin, Familial1CTD_human