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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BCL7A-KCNIP3 (FusionGDB2 ID:HG605TG30818)

Fusion Gene Summary for BCL7A-KCNIP3

check button Fusion gene summary
Fusion gene informationFusion gene name: BCL7A-KCNIP3
Fusion gene ID: hg605tg30818
HgeneTgene
Gene symbol

BCL7A

KCNIP3

Gene ID

605

30818

Gene nameBAF chromatin remodeling complex subunit BCL7Apotassium voltage-gated channel interacting protein 3
SynonymsBCL7CSEN|DREAM|KCHIP3
Cytomap('BCL7A')('KCNIP3')

12q24.31

2q11.1

Type of geneprotein-codingprotein-coding
DescriptionB-cell CLL/lymphoma 7 protein family member AB-cell CLL/lymphoma 7AB-cell CLL/lymphoma-7BCL tumor suppressor 7ABCL7A, BAF complex componentcalsenilinA-type potassium channel modulatory protein 3DRE-antagonist modulatorKv channel interacting protein 3, calsenilincalsenilin, presenilin-binding protein, EF hand transcription factorkv channel-interacting protein 3potassium channel interact
Modification date2020031320200320
UniProtAcc

Q4VC05

.
Ensembl transtripts involved in fusion geneENST00000261822, ENST00000538010, 
Fusion gene scores* DoF score8 X 6 X 6=2884 X 5 X 3=60
# samples 96
** MAII scorelog2(9/288*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/60*10)=0
Context

PubMed: BCL7A [Title/Abstract] AND KCNIP3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBCL7A(122473333)-KCNIP3(96040044), # samples:3
Anticipated loss of major functional domain due to fusion event.BCL7A-KCNIP3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BCL7A-KCNIP3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across BCL7A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across KCNIP3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AO-A03U-01BBCL7Achr12

122473333

-KCNIP3chr2

96040044

+
ChimerDB4BRCATCGA-AO-A03U-01BBCL7Achr12

122473333

+KCNIP3chr2

96040044

+


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Fusion Gene ORF analysis for BCL7A-KCNIP3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000261822ENST00000360990BCL7Achr12

122473333

+KCNIP3chr2

96040044

+
5CDS-3UTRENST00000261822ENST00000377181BCL7Achr12

122473333

+KCNIP3chr2

96040044

+
5CDS-3UTRENST00000261822ENST00000468529BCL7Achr12

122473333

+KCNIP3chr2

96040044

+
5CDS-3UTRENST00000538010ENST00000360990BCL7Achr12

122473333

+KCNIP3chr2

96040044

+
5CDS-3UTRENST00000538010ENST00000377181BCL7Achr12

122473333

+KCNIP3chr2

96040044

+
5CDS-3UTRENST00000538010ENST00000468529BCL7Achr12

122473333

+KCNIP3chr2

96040044

+
In-frameENST00000261822ENST00000295225BCL7Achr12

122473333

+KCNIP3chr2

96040044

+
In-frameENST00000538010ENST00000295225BCL7Achr12

122473333

+KCNIP3chr2

96040044

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000538010BCL7Achr12122473333+ENST00000295225KCNIP3chr296040044+5559294126703530286
ENST00000261822BCL7Achr12122473333+ENST00000295225KCNIP3chr296040044+30954772061066286

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000538010ENST00000295225BCL7Achr12122473333+KCNIP3chr296040044+0.0014751830.99852484
ENST00000261822ENST00000295225BCL7Achr12122473333+KCNIP3chr296040044+0.0019121920.9980878

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Fusion Genomic Features for BCL7A-KCNIP3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
BCL7Achr12122473333+KCNIP3chr296040043+4.30E-070.9999995
BCL7Achr12122473333+KCNIP3chr296040043+4.30E-070.9999995

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for BCL7A-KCNIP3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:122473333/chr2:96040044)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BCL7A

Q4VC05

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKCNIP3chr12:122473333chr2:96040044ENST0000029522519175_18660257.0Calcium binding1
TgeneKCNIP3chr12:122473333chr2:96040044ENST0000029522519223_23460257.0Calcium binding2
TgeneKCNIP3chr12:122473333chr2:96040044ENST0000046852908175_18634231.0Calcium binding1
TgeneKCNIP3chr12:122473333chr2:96040044ENST0000046852908223_23434231.0Calcium binding2
TgeneKCNIP3chr12:122473333chr2:96040044ENST0000029522519126_16160257.0DomainEF-hand 2
TgeneKCNIP3chr12:122473333chr2:96040044ENST0000029522519162_19760257.0DomainEF-hand 3
TgeneKCNIP3chr12:122473333chr2:96040044ENST0000029522519210_24560257.0DomainEF-hand 4
TgeneKCNIP3chr12:122473333chr2:96040044ENST000002952251967_12360257.0DomainEF-hand 1%3B degenerate
TgeneKCNIP3chr12:122473333chr2:96040044ENST0000046852908126_16134231.0DomainEF-hand 2
TgeneKCNIP3chr12:122473333chr2:96040044ENST0000046852908162_19734231.0DomainEF-hand 3
TgeneKCNIP3chr12:122473333chr2:96040044ENST0000046852908210_24534231.0DomainEF-hand 4
TgeneKCNIP3chr12:122473333chr2:96040044ENST000004685290867_12334231.0DomainEF-hand 1%3B degenerate

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for BCL7A-KCNIP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>9435_9435_1_BCL7A-KCNIP3_BCL7A_chr12_122473333_ENST00000261822_KCNIP3_chr2_96040044_ENST00000295225_length(transcript)=3095nt_BP=477nt
ACTGGGCCAGGCGCGCGGCGGCCCCGGGCTTTGTGTGTGTGTGTATGTGTGTGTGTGTGTGTGTGTGTGTGTGAGTGTGTGCGTGTGAGA
GTGCGAGTGTCTGTGCGCGAGTGAGTGAGCGGCGGGCGGGCGCGAGTGTGGCCGCCGCGGAGCGCGAGCAGGACCCGGCGGGCGCGCTCC
CCAGCCTCCGTCTCCCCGCCGGAACCATGTCGGGCAGGTCGGTTCGAGCCGAGACGAGGAGCCGGGCCAAAGATGATATCAAGAGGGTCA
TGGCGGCGATCGAGAAAGTGCGCAAATGGGAGAAGAAATGGGTGACCGTTGGTGACACATCCCTACGAATCTACAAATGGGTCCCTGTGA
CGGAGCCCAAGGTTGATGACAAAAACAAGAATAAGAAAAAAGGCAAGGACGAGAAGTGTGGCTCAGAGGTGACCACTCCGGAGAACAGTT
CCTCCCCAGGGATGATGGACATGCATGATAGCAGCGACAGTGAGCTGGAGCTGTCCACGGTGCGCCACCAGCCAGAGGGGCTGGACCAGC
TGCAGGCCCAGACCAAGTTCACCAAGAAGGAGCTGCAGTCTCTCTACAGGGGCTTTAAGAATGAGTGTCCCACGGGCCTGGTGGACGAAG
ACACCTTCAAACTCATTTACGCGCAGTTCTTCCCTCAGGGAGATGCCACCACCTATGCACACTTCCTCTTCAACGCCTTTGATGCGGACG
GGAACGGGGCCATCCACTTTGAGGACTTTGTGGTTGGCCTCTCCATCCTGCTGCGGGGCACAGTCCACGAGAAGCTCAAGTGGGCCTTTA
ATCTCTACGACATTAACAAGGATGGCTACATCACCAAAGAGGAGATGCTGGCCATCATGAAGTCCATCTATGACATGATGGGCCGCCACA
CCTACCCCATCCTGCGGGAGGACGCGCCGGCGGAGCACGTGGAGAGGTTCTTCGAGAAAATGGACCGGAACCAGGATGGGGTAGTGACCA
TTGAAGAGTTCCTGGAGGCCTGTCAGAAGGATGAGAACATCATGAGCTCCATGCAGCTGTTTGAGAATGTCATCTAGGACACGTCCAAAG
GAGTGCATGGCCACAGCCACCTCCACCCCCAAGAAACCTCCATCCTGCCAGGAGCAGCCTCCAAGAAACTTTTAAAAAATAGATTTGCAA
AAAGTGAACAGATTGCTACACACACACACACACACACACACACACACACACACAGCCATTCATCTGGGCTGGCAGAGGGGACAGAGTTCA
GGGAGGGGCTGAGTCTGGCTAGGGGCCGAGTCCAGGAGCCCCAGCCAGCCCTTCCCAGGCCAGCGAGGCGAGGCTGCCTCTGGGTGAGTG
GCTGACAGAGCAGGTCTGCAGGCCACCAGCTGCTGGATGTCACCAAGAAGGGGCTCGAGTGCCCCTGCAGGGGAGGGTCCAATCTCCGGT
GTGAGCCCACCTCGTCCCGTTCTCCATTCTGCTTTCTTGCCACACAGTGGGCCGGCCCCAGGCTCCCCTGGTCTCCTCCCCGTAGCCACT
CTCTGCCCACTACCTATGCTTCTAGAAAGCCCCTCACCTCAGGACCCCAGAGGGACCAGCTGGGGGGCAGGGGGGAGAGGGGGTAATGGA
GGCCAAGCCTGCAGCTTTCTGGAAATTCTTCCCTGGGGGTCCCAGGATCCCCTGCTACTCCACTGACCTGGAAGAGCTGGGTACCAGGCC
ACCCACTGTGGGGCAAGCCTGAGTGGTGAGGGGCCACTGGGCCCCATTCTCCCTCCATGGCAGGAAGGCGGGGGATTTCAAGTTTAGGGA
TTGGGTCGTGGTGGAGAATCTGAGGGCACTCTCTGCCAGCTCCACAGGGTGGGATGAGCCTCTCCTTGCCCCAGTCCTGGTTCAGTGGGA
ATGCAGTGGGTGGGGCTGTACACACCCTCCAGCACAGACTGTTCCCTCCAAGGTCCTCTTAGGTCCCGGGAGGAACGTGGTTCAGAGACT
GGCAGCCAGGGAGCCCGGGGCAGAGCTCAGAGGAGTCTGGGAAGGGGCGTGTCCCTCCTCTTCCTGTAGTGCCCCTCCCATGGCCCAGCA
GCTTGGCTGAGCCCCCTCTCCTGAAGCAGTGTCGCCGTCCCTCTGCCTTGCACAAAAAGCACAAGCATTCCTTAGCAGCTCAGGCGCAGC
CCTAGTGGGAGCCCAGCACACTGCTTCTCGGAGGCCAGGCCCTCCTGCTGGCTGAGGCTTGGGCCCAGTAGCCCCAATATGGTGGCCCTG
GGGAAGAGGCCTTGGGGGTCTGCTCTGTGCCTGGGATCAGTGGGGCCCCAAAGCCCAGCCCGGCTGACCAACATTCAAAAGCACAAACCC
TGGGGACTCTGCTTGGCTGTCCCCTCCATCTGGGGATGGAGAATGCCAGCCCAAAGCTGGAGCCAATGGTGAGGGCTGAGAGGGCTGTGG
CTGGGTGGTCAGCAGAAACCCCCAGGAGGAGAGAGATGCTGCTCCCGCCTGATTGGGGCCTCACCCAGAAGGAACCCGGTCCCAGGCCGC
ATGGCCCCTCCAGGAACATTCCCACATAATACATTCCATCACAGCCAGCCCAGCTCCACTCAGGGCTGGCCCGGGGAGTCCCCGTGTGCC
CCAAGAGGCTAGCCCCAGGGTGAGCAGGGCCCTCAGAGGAAAGGCAGTATGGCGGAGGCCATGGGGGCCCCTCGGCATTCACACACAGCC
TGGCCTCCCCTGCGGAGCTGCATGGACGCCTGGCTCCAGGCTCCAGGCTGACTGGGGGCCTCTGCCTCCAGGAGGGCATCAGCTTTCCCT
GGCTCAGGGATCTTCTCCCTCCCCTCACCCGCTGCCCAGCCCTCCCAGCTGGTGTCACTCTGCCTCTAAGGCCAAGGCCTCAGGAGAGCA
TCACCACCACACCCCTGCCGGCCTTGGCCTTGGGGCCAGACTGGCTGCACAGCCCAACCAGGAGGGGTCTGCCTCCCACGCTGGGACACA
GACCGGCCGCATGTCTGCATGGCAGAAGCGTCTCCCTTGGCCACGGCCTGGGAGGGTGGTTCCTGTTCTCAGCATCCACTAATATTCAGT

>9435_9435_1_BCL7A-KCNIP3_BCL7A_chr12_122473333_ENST00000261822_KCNIP3_chr2_96040044_ENST00000295225_length(amino acids)=286AA_BP=90
MSGRSVRAETRSRAKDDIKRVMAAIEKVRKWEKKWVTVGDTSLRIYKWVPVTEPKVDDKNKNKKKGKDEKCGSEVTTPENSSSPGMMDMH
DSSDSELELSTVRHQPEGLDQLQAQTKFTKKELQSLYRGFKNECPTGLVDEDTFKLIYAQFFPQGDATTYAHFLFNAFDADGNGAIHFED
FVVGLSILLRGTVHEKLKWAFNLYDINKDGYITKEEMLAIMKSIYDMMGRHTYPILREDAPAEHVERFFEKMDRNQDGVVTIEEFLEACQ

--------------------------------------------------------------
>9435_9435_2_BCL7A-KCNIP3_BCL7A_chr12_122473333_ENST00000538010_KCNIP3_chr2_96040044_ENST00000295225_length(transcript)=5559nt_BP=2941nt
CCCAGCCTAGATTTCTTTTTATTATGATCAAATACACATAAAATTGACCATTGTAACCATTTAAAAGTGTACAATTCAGCGTCATTAAGT
ACATTCACATTGTTCTGCAACCATCACCACTATCTCATTCCAGAACTTTCCTATCACTCCGAAAGGAAACCCCACATCCGTTAGCAGTCA
CTCCTGCTCTCCCTCCCCCTTGCCTCTGGCAACCACCAATCTGATATCTGTCTTTATGGATTCGCCTAGTTGTAGATATCTCCCGCAAAT
GGACTTACGCATATTTATCCTTTTGTGACTGGCTTCTTTCACTTAGCGTGTTTCAAGGTTCACCCATGTTGTAGCATGTATTCATTCCCT
TTTATGGCTGAATAATATTCCATTGTGTGGATAGACACATTTATCTGTTCCTCAGTCACTATTTGAATTCTGACATAATATTTTCCTATT
TTAAATTTTAAGATACATTTTTTTAAAGTTTCATGTGGCCCAAAGCACATACCTATTGATCTCACATATCTCTGTGAGATCTGTTTTATG
ACCTGCTGTTGCATATTTTCCCAGAAAATTCTCGGAACGATTCTCTGAAGTCCTTCTTTCTCTTTCTCTTTTTTTTCTTTTTCTTTCTCT
CTTTCTTTTTTTGTTTTGTTTTGTTTTATTTTGTTTTGTTTTGTTTTTTTGAGATTCAGTTTTGCTCTGTTGCCCAGGCTGGAGTGCAAT
GGCATGATCATTGCACCTCTGCCTCCCAGGTTCAAGCATTTTCCTGCCTCAGCCTCCCGCGTAGCTCAGATTACAGGCCTGCACCACCAC
GCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCTCCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCGTGATCTGCCCAC
TTCGGCCTCCAAAGTGCTGGGATTACAGGCATGAACCACCGCGCCCGGCCTTTTTTTTTTTTCTGAGACAGGGTCTCACTCTGTCTCCCA
GGCTGGAGTGCAGTGGCTGGATCTCTGCTCACTGCAACCTCCGTCTCCCAGGTTCAAGCGAGTCTCCTGCCTCAGACTCCCGAGTAGCTG
CGATTACAGGAGCCCACCACCGCGCCCGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCCACCATGTTGGCCAGGCTGGTATC
GAACTCTTAACCTCAAGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTGGTATTACAGGCATGAGCCACCGCGCCCGGCCAGTATTTGTT
CTTTTCTTCATTTTTCACGTCAGGAGACTGCGTTTCAGAATAGTAAAAACAAATGCCTAGGAAAAGGCCTGCGGTCTCTCCATTTCCACA
GTAGCGTGTTCCCCAAAGACCAAACCCTCAGGGGAAACGTCTAGAATGAGTAACAACTTAAGGCTGCAACCTTAAACTTTCCCAGGACTC
AGTTTCCCCAGCTGTGAAATGGCTGCTGTCGGGCTGTCATCTCCAGGCCCGGGGCGCTGACATTTGGGCCACTCTCGGTCTCCCTCTTCA
TTCTGGGCGCGCATTAGCTCTGGTCCGGCCGGTTCCGCTGCAGCTGAACAGCAAGATGCGGCACCCAGGTTACCCTGATCATCGCAGATT
TCTCCCCGGGGCTCTGTTCTGAGGCCTCAAAAGTGCTCCTTGTAGATGGGACCAGGGGTCATTTGGGCAGTAGCAGCGCCTGGTCTCAGT
CTGGTACTGAAGTCAGGAATGGCTTAAGGTGAAATCGTGGTCCTCTGGTGAAGCTCAGCGAAGACCCCCTCGCCTTGTTTATGACAAGAG
AACTTCTGGGGGCGGGAGGAAGAGTCCCTGTTACGATGCTGATCATCATTGAGCTTTTGCTGAGCAGAAAACTCTTTAGTACTCAAGGTC
GAGAGTCTCTGGTGGTCTGCCTGGCACCAGGCACCTTCCTACAACCCTAGTTTTCCAAAAGGACAAAGCCTGGGGCAGGCGACGTCCTAG
CTCGCATTTGAACAGGGCCGCGGGCCAGCAGAGATGCGCGATGCCCAACTCTTTCCAAGAGCACCTCGCGTCCCGAACCGGTGCCTTCAA
CTCGGAGAAGTCAAGAGACCCGCAAGAAACTTGCACGACTGCACCCGCCGCCGCGCTCTGGGGGCTGGGCAGGGGCAGCTGGGCTGGCTC
CCGGGGAACGCGACCCCCCCGCGCCCCGCAGACCGGCTGTCTCCCATGGACCCCTCGGCACCTGCAGCCTCCGAGGAAGGGTCAGCGCGC
GTGTCCGCACGCCCGCCCCCACCGCGCGCCCAGAGCCGGGGGTCGCCGTGCGCCCTTCGCCACCTCCCCAGGAGGGCGTCCGGGGCGTCC
CCTCTGGGGGCGCAGGAGGCCCGGGGGCGCTGCCCGGTGGCCGCGGCGCCCGGAGGCCGCACTGCCGGCGGCGGCGGCGGCGCGGCTCCC
CCTGCTCTGTGCAGCTGCCGCCCGGCGCTTGCGCACTGGGCCAGGCGCGCGGCGGCCCCGGGCTTTGTGTGTGTGTGTATGTGTGTGTGT
GTGTGTGTGTGTGTGTGAGTGTGTGCGTGTGAGAGTGCGAGTGTCTGTGCGCGAGTGAGTGAGCGGCGGGCGGGCGCGAGTGTGGCCGCC
GCGGAGCGCGAGCAGGACCCGGCGGGCGCGCTCCCCAGCCTCCGTCTCCCCGCCGGAACCATGTCGGGCAGGTCGGTTCGAGCCGAGACG
AGGAGCCGGGCCAAAGATGATATCAAGAGGGTCATGGCGGCGATCGAGAAAGTGCGCAAATGGGAGAAGAAATGGGTGACCGTTGGTGAC
ACATCCCTACGAATCTACAAATGGGTCCCTGTGACGGAGCCCAAGGTTGATGACAAAAACAAGAATAAGAAAAAAGGCAAGGACGAGAAG
TGTGGCTCAGAGGTGACCACTCCGGAGAACAGTTCCTCCCCAGGGATGATGGACATGCATGATAGCAGCGACAGTGAGCTGGAGCTGTCC
ACGGTGCGCCACCAGCCAGAGGGGCTGGACCAGCTGCAGGCCCAGACCAAGTTCACCAAGAAGGAGCTGCAGTCTCTCTACAGGGGCTTT
AAGAATGAGTGTCCCACGGGCCTGGTGGACGAAGACACCTTCAAACTCATTTACGCGCAGTTCTTCCCTCAGGGAGATGCCACCACCTAT
GCACACTTCCTCTTCAACGCCTTTGATGCGGACGGGAACGGGGCCATCCACTTTGAGGACTTTGTGGTTGGCCTCTCCATCCTGCTGCGG
GGCACAGTCCACGAGAAGCTCAAGTGGGCCTTTAATCTCTACGACATTAACAAGGATGGCTACATCACCAAAGAGGAGATGCTGGCCATC
ATGAAGTCCATCTATGACATGATGGGCCGCCACACCTACCCCATCCTGCGGGAGGACGCGCCGGCGGAGCACGTGGAGAGGTTCTTCGAG
AAAATGGACCGGAACCAGGATGGGGTAGTGACCATTGAAGAGTTCCTGGAGGCCTGTCAGAAGGATGAGAACATCATGAGCTCCATGCAG
CTGTTTGAGAATGTCATCTAGGACACGTCCAAAGGAGTGCATGGCCACAGCCACCTCCACCCCCAAGAAACCTCCATCCTGCCAGGAGCA
GCCTCCAAGAAACTTTTAAAAAATAGATTTGCAAAAAGTGAACAGATTGCTACACACACACACACACACACACACACACACACACACAGC
CATTCATCTGGGCTGGCAGAGGGGACAGAGTTCAGGGAGGGGCTGAGTCTGGCTAGGGGCCGAGTCCAGGAGCCCCAGCCAGCCCTTCCC
AGGCCAGCGAGGCGAGGCTGCCTCTGGGTGAGTGGCTGACAGAGCAGGTCTGCAGGCCACCAGCTGCTGGATGTCACCAAGAAGGGGCTC
GAGTGCCCCTGCAGGGGAGGGTCCAATCTCCGGTGTGAGCCCACCTCGTCCCGTTCTCCATTCTGCTTTCTTGCCACACAGTGGGCCGGC
CCCAGGCTCCCCTGGTCTCCTCCCCGTAGCCACTCTCTGCCCACTACCTATGCTTCTAGAAAGCCCCTCACCTCAGGACCCCAGAGGGAC
CAGCTGGGGGGCAGGGGGGAGAGGGGGTAATGGAGGCCAAGCCTGCAGCTTTCTGGAAATTCTTCCCTGGGGGTCCCAGGATCCCCTGCT
ACTCCACTGACCTGGAAGAGCTGGGTACCAGGCCACCCACTGTGGGGCAAGCCTGAGTGGTGAGGGGCCACTGGGCCCCATTCTCCCTCC
ATGGCAGGAAGGCGGGGGATTTCAAGTTTAGGGATTGGGTCGTGGTGGAGAATCTGAGGGCACTCTCTGCCAGCTCCACAGGGTGGGATG
AGCCTCTCCTTGCCCCAGTCCTGGTTCAGTGGGAATGCAGTGGGTGGGGCTGTACACACCCTCCAGCACAGACTGTTCCCTCCAAGGTCC
TCTTAGGTCCCGGGAGGAACGTGGTTCAGAGACTGGCAGCCAGGGAGCCCGGGGCAGAGCTCAGAGGAGTCTGGGAAGGGGCGTGTCCCT
CCTCTTCCTGTAGTGCCCCTCCCATGGCCCAGCAGCTTGGCTGAGCCCCCTCTCCTGAAGCAGTGTCGCCGTCCCTCTGCCTTGCACAAA
AAGCACAAGCATTCCTTAGCAGCTCAGGCGCAGCCCTAGTGGGAGCCCAGCACACTGCTTCTCGGAGGCCAGGCCCTCCTGCTGGCTGAG
GCTTGGGCCCAGTAGCCCCAATATGGTGGCCCTGGGGAAGAGGCCTTGGGGGTCTGCTCTGTGCCTGGGATCAGTGGGGCCCCAAAGCCC
AGCCCGGCTGACCAACATTCAAAAGCACAAACCCTGGGGACTCTGCTTGGCTGTCCCCTCCATCTGGGGATGGAGAATGCCAGCCCAAAG
CTGGAGCCAATGGTGAGGGCTGAGAGGGCTGTGGCTGGGTGGTCAGCAGAAACCCCCAGGAGGAGAGAGATGCTGCTCCCGCCTGATTGG
GGCCTCACCCAGAAGGAACCCGGTCCCAGGCCGCATGGCCCCTCCAGGAACATTCCCACATAATACATTCCATCACAGCCAGCCCAGCTC
CACTCAGGGCTGGCCCGGGGAGTCCCCGTGTGCCCCAAGAGGCTAGCCCCAGGGTGAGCAGGGCCCTCAGAGGAAAGGCAGTATGGCGGA
GGCCATGGGGGCCCCTCGGCATTCACACACAGCCTGGCCTCCCCTGCGGAGCTGCATGGACGCCTGGCTCCAGGCTCCAGGCTGACTGGG
GGCCTCTGCCTCCAGGAGGGCATCAGCTTTCCCTGGCTCAGGGATCTTCTCCCTCCCCTCACCCGCTGCCCAGCCCTCCCAGCTGGTGTC
ACTCTGCCTCTAAGGCCAAGGCCTCAGGAGAGCATCACCACCACACCCCTGCCGGCCTTGGCCTTGGGGCCAGACTGGCTGCACAGCCCA
ACCAGGAGGGGTCTGCCTCCCACGCTGGGACACAGACCGGCCGCATGTCTGCATGGCAGAAGCGTCTCCCTTGGCCACGGCCTGGGAGGG

>9435_9435_2_BCL7A-KCNIP3_BCL7A_chr12_122473333_ENST00000538010_KCNIP3_chr2_96040044_ENST00000295225_length(amino acids)=286AA_BP=90
MSGRSVRAETRSRAKDDIKRVMAAIEKVRKWEKKWVTVGDTSLRIYKWVPVTEPKVDDKNKNKKKGKDEKCGSEVTTPENSSSPGMMDMH
DSSDSELELSTVRHQPEGLDQLQAQTKFTKKELQSLYRGFKNECPTGLVDEDTFKLIYAQFFPQGDATTYAHFLFNAFDADGNGAIHFED
FVVGLSILLRGTVHEKLKWAFNLYDINKDGYITKEEMLAIMKSIYDMMGRHTYPILREDAPAEHVERFFEKMDRNQDGVVTIEEFLEACQ

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Fusion Gene PPI Analysis for BCL7A-KCNIP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneKCNIP3chr12:122473333chr2:96040044ENST0000029522519243_25660.333333333333336257.0KCND2
TgeneKCNIP3chr12:122473333chr2:96040044ENST0000046852908243_25634.333333333333336231.0KCND2


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BCL7A-KCNIP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BCL7A-KCNIP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource