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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BDH1-C7orf60 (FusionGDB2 ID:HG622TG154743)

Fusion Gene Summary for BDH1-C7orf60

check button Fusion gene summary
Fusion gene informationFusion gene name: BDH1-C7orf60
Fusion gene ID: hg622tg154743
HgeneTgene
Gene symbol

BDH1

C7orf60

Gene ID

622

154743

Gene name3-hydroxybutyrate dehydrogenase 1base methyltransferase of 25S rRNA 2 homolog
SynonymsBDH|SDR9C1C7orf60|SAMTOR
Cytomap('BDH1','BDH1')('BMT2','C7orf60')

3q29

7q31.1

Type of geneprotein-codingprotein-coding
DescriptionD-beta-hydroxybutyrate dehydrogenase, mitochondrial(R)-3-hydroxybutyrate dehydrogenase3-hydroxybutyrate dehydrogenase (heart, mitochondrial)3-hydroxybutyrate dehydrogenase, type 1epididymis secretory sperm binding proteinshort chain dehydrogenase/redS-adenosylmethionine sensor upstream of mTORC1UPF0532 protein C7orf60probable methyltransferase BMT2 homologprobable methyltransferase BTM2 homolog
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000358186, ENST00000392378, 
ENST00000392379, ENST00000441275, 
ENST00000476764, 
Fusion gene scores* DoF score5 X 5 X 4=1002 X 2 X 2=8
# samples 52
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: BDH1 [Title/Abstract] AND C7orf60 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBDH1(197273232)-BMT2(112472730), # samples:1
BDH1(197273232)-C7orf60(112472730), # samples:1
Anticipated loss of major functional domain due to fusion event.BDH1-C7orf60 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
BDH1-C7orf60 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneC7orf60

GO:0034198

cellular response to amino acid starvation

29123071

TgeneC7orf60

GO:1904262

negative regulation of TORC1 signaling

29123071


check buttonFusion gene breakpoints across BDH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across C7orf60 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-XF-AAMX-01ABDH1chr3

197273232

-BMT2chr7

112472730

-
ChimerDB4BLCATCGA-XF-AAMX-01ABDH1chr3

197273232

-C7orf60chr7

112472730

-


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Fusion Gene ORF analysis for BDH1-C7orf60

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000358186ENST00000485446BDH1chr3

197273232

-C7orf60chr7

112472730

-
5CDS-5UTRENST00000392378ENST00000485446BDH1chr3

197273232

-C7orf60chr7

112472730

-
5CDS-5UTRENST00000392379ENST00000485446BDH1chr3

197273232

-C7orf60chr7

112472730

-
Frame-shiftENST00000392379ENST00000297145BDH1chr3

197273232

-C7orf60chr7

112472730

-
In-frameENST00000358186ENST00000297145BDH1chr3

197273232

-C7orf60chr7

112472730

-
In-frameENST00000392378ENST00000297145BDH1chr3

197273232

-C7orf60chr7

112472730

-
intron-3CDSENST00000441275ENST00000297145BDH1chr3

197273232

-C7orf60chr7

112472730

-
intron-3CDSENST00000476764ENST00000297145BDH1chr3

197273232

-C7orf60chr7

112472730

-
intron-5UTRENST00000441275ENST00000485446BDH1chr3

197273232

-C7orf60chr7

112472730

-
intron-5UTRENST00000476764ENST00000485446BDH1chr3

197273232

-C7orf60chr7

112472730

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000392378BDH1chr3197273232-ENST00000297145C7orf60chr7112472730-37363943111138275
ENST00000358186BDH1chr3197273232-ENST00000297145C7orf60chr7112472730-36112691861013275

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000392378ENST00000297145BDH1chr3197273232-C7orf60chr7112472730-0.0002802510.9997197
ENST00000358186ENST00000297145BDH1chr3197273232-C7orf60chr7112472730-0.0002547430.9997453

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Fusion Genomic Features for BDH1-C7orf60


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for BDH1-C7orf60


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:197273232/chr7:112472730)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBDH1chr3:197273232chr7:112472730ENST00000358186-2759_8327344.0Nucleotide bindingNAD
HgeneBDH1chr3:197273232chr7:112472730ENST00000392378-2759_8327344.0Nucleotide bindingNAD
HgeneBDH1chr3:197273232chr7:112472730ENST00000392379-3859_8327344.0Nucleotide bindingNAD


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Fusion Gene Sequence for BDH1-C7orf60


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>9554_9554_1_BDH1-C7orf60_BDH1_chr3_197273232_ENST00000358186_C7orf60_chr7_112472730_ENST00000297145_length(transcript)=3611nt_BP=269nt
ATTGAAAGAATACACAGAAAGCCTGGAAAAGGTTTCCAGGGGTGTCAATACGCCCTGTCAACTGAGAATTAAGAGGATCCGGCTGGTCAC
TTGCCTGGAGAGGATCCTGCATGCTGATAGTGCTGAGGCACCTGCCAGCTAAGAACCACCGGGAGGAACTGGGCCATTCTAACACCCGTT
GCTACCATGCTGGCCACCCGCCTCTCCAGACCCCTGTCACGGCTCCCAGGAAAAACCCTAAGTGCCTGTGATAGAGAAAATGGAGCAAGG
TTGCTACAAGCCTCAGGAAAAATCAGATTACTTGATGTTGGCAGCTGCTTTAACCCATTTCTGAAGTTTGAAGAATTTCTAACTGTTGGC
ATAGATATTGTACCTGCTGTAGAGAGTGTCTATAAATGTGATTTCCTGAACTTACAGCTTCAGCAACCACTCCAGCTTGCACAGGATGCT
ATAGATGCTTTTTTGAAGCAGCTGAAAAACCCTATTGATTCTCTTCCTGGAGAGCTTTTCCATGTGGTTGTTTTCTCTCTCCTTCTTTCT
TATTTTCCATCTCCTTACCAGCGATGGATTTGCTGCAAGAAAGCCCATGAACTGTTAGTGTTAAATGGTTTATTACTAATCATCACACCT
GATTCCTCCCATCAGAACCGTCATGCTATGATGATGAAAAGCTGGAAGATTGCTATAGAGTCCCTGGGCTTTAAACGCTTCAAGTACTCA
AAATTTTCACATATGCATCTGATGGCATTTAGGAAAATCTCTCTAAAAACCACAAGTGACTTGGTTAGTAGGAACTACCCAGGAATGTTA
TATATTCCTCAAGATTTCAACAGTATAGAAGATGAGGAATATTCTAACCCTTCCTGCTATGTTCGATCAGATATAGAAGATGAACAACTA
GCATATGGTTTCACAGAACTCCCTGATGCGCCATATGACTCAGATTCTGGAGAAAGTCAAGCCAGCTCTATTCCTTTCTATGAGCTAGAA
GACCCCATATTACTTTTAAGTTAATATAGAAGCAAAAAGCCCCTTTCAGTCCAGGCTCCTAAACTAATTGCTTACACCAATTGGAAATAC
TAACATGAACTCAGTACTGAAAACCTGGTTTGCATAAAAGAAATGCAGAGGTTTACAGAGTTTGCTATTTTTTTCTACTTCTCAATTTTA
AAATTTATTCTTATATAGAAAGCTTAAAGTTTCATGCAGAGTGACTCATGTCATAGCAGAAACTACTGTTACTTTAGCATTTAGCACTAT
CATAGAAAGGTACCTTTTTCTCTTTAGTGCTATTGTGAAAACAAGCATAATTTGCTATATGTTTTCCTTTTCAACTTTTCAGTGTTGACT
ATAAACCATTGAATGGAAAACTTTAAGATGTAGAAAGCTGTAGATTGCACTTTGATGACTCACAAGTTAAATGTGATACAGAAAAATAGA
TCGGTTAGTTGTTTTGTGATGCACTTATCTTTTTCTTTTTTCTAACTAAAATTGTGATGTTACAGAAAGTCATTTTATGTTCCTTTTTTG
TCTGATGATCCAATATTTACTGAACTTTTTGTAATTGGTGATAATTCTTTTTATTTCTTCCTTATATTAAAAGCTCATTTGACAGCATCA
GACATTGGGGGAGAGATGTCCCCCAAAGTGTGTATTCTAATTTTATTAGCCCTATCCAATAAACACCATTGCCAAAGTAGTATTTTCATA
ACTTTCTTGTTGATTTGGGCCTTGGTGTGAAGTATATTTACCTGAGAGTTCACTTTTACTTTTCTTAAACTTAGGCTTCATTTACAAAAT
GTTTTATTTAAGCAAGGAACAATGTAATACTCAATAATGACCTAAAACACCTTTTTGAAAGGGTTTGCACTTGGAAGAGAGTTTATGTTC
TGTTGAAACCAACTTTGATAGGGTCCTCACCTTTCCGTTAAGGAGGTGCCGCACTACAAGTTTCAAATTATATGGAAAAACCTAAAATTA
ACCCTCTGTTGGTGATCTCATAAAATGGTTTTGACCTTTTGGTATCTTAATTTCTATCTAAACTTTATCAGAAAATTTTCTTTGAATATA
TCAATTAGTTGGCTGTGGGAATTTTCCCTTTCCACATTAATAAATGCCTTTCTGTGTTTCTGAATCAGAAGCAAATGATTAGGGAAAAAT
ATATGTCCAAACAAGACAAGATTAGTTTAAACAGTTAAGAACATTTAGTCCACATTGTCTTGTCAGCCAGCAATTGTCATGGAAGCTATC
ATTTTTAAGAGTGCCACTGTGTGGATTTTTTTTTCAAGTGGTTATTACATTAAAATTACCTCATACTGAGGTTTTTGCACTGAAATATCA
CAGTTTCAGATTTCATGGTTAATGTTGTGCGTATGTTTGTATGTTTTTAAAGGAAACTTGCATTTTCAATAGTTGATCCTAAATTTCATA
AACTGCACTTCTTTACTCTGGTAAAGCTGATGTTTTTGTGCTTATTGTGAATTGCCGTAGTACCTTTGAATGTCAAACTTTATTTAGAAA
TATAAAACTTATCCTTTATGATATAAATGGTTGAGTGTATGTACCCAGTATTTCTAATTAAATTTCACATGCTAAATTAATGAAAGTAAC
AAGATTGTAATTTTTTAAAGTCAGTTGATTAAATGCAATAAATATTGGTTGCTCAAATATGCCACAAATAACTCGAAATTTTTCATTTAC
TTTCAACAGCATAAGATTCTTTAATATTTAGGATTGACTGTTCTTTCCAGTTAAGCACTGAAGGATTATGTCTTGTAGCTTCCCCAAGAG
AAGGGGAAGGAAAAAAAAGCACTATGTTAAGGATAATACAGAACTCTTTTGAACTATTTTGGTAGTACCTTTTACCATACTGTTTGCTTT
TTGATTTGGGTAAATATCTTAAGAGCAAAGAAAACAATACACCAAATGAAAATGCTTTGAAAGTAAATGAAAACAGCGCTTTTGAAAGGC
TGGTATAGTATGACCCTGGAGTCAGCCTTTGTGTTACAGCGAAAATGTTGGTGCTATAAATTCTGATTGTTTACAGATGTTGATTCTGCT
TATGCTCCAAAGTGTGCATGATGTATTTTACGTAGTACTCTGAGGAAGTCTCTTTATAAAACCTACTACCACTTAGTATAAATTTGTTTG
AATTTATATCATTTGTTACTGTAAATTCAGCTTATTCCAATTAGGTTGGCACAGATTTAAACTGATACACATTCCACAAAAACCAATTCA
GTGTATAAGTATTGAAGTATAAGCAGTCATTGCAGCTTGATGCCAGATCATGTATGTAATAACAAGTGGAAGTTAATAGGGCCTTCTAAT
ACTGTATGGGTACTCCTAAGAATTATTTCATTTTGGATATAAAGAAGTTATGAGGCCTCCTGTCACATTCACAGCTGGTTCTCCAAAATA
ATTTGGTTGTTTCAAAAACAAATGGTAATCATTTGGTTGGATTCTTCAGTATCATGACTAGATCATGTGGTTTTACCATAGTTGCCAAGT
GGTGGGAGGTAGCATACCTGAAAATGTACGTGTGTGTTTGTTGTATTTTTTCACATTTTGTGAACAAAGCACATTTATTAAAAATTTTAA

>9554_9554_1_BDH1-C7orf60_BDH1_chr3_197273232_ENST00000358186_C7orf60_chr7_112472730_ENST00000297145_length(amino acids)=275AA_BP=27
MLATRLSRPLSRLPGKTLSACDRENGARLLQASGKIRLLDVGSCFNPFLKFEEFLTVGIDIVPAVESVYKCDFLNLQLQQPLQLAQDAID
AFLKQLKNPIDSLPGELFHVVVFSLLLSYFPSPYQRWICCKKAHELLVLNGLLLIITPDSSHQNRHAMMMKSWKIAIESLGFKRFKYSKF
SHMHLMAFRKISLKTTSDLVSRNYPGMLYIPQDFNSIEDEEYSNPSCYVRSDIEDEQLAYGFTELPDAPYDSDSGESQASSIPFYELEDP

--------------------------------------------------------------
>9554_9554_2_BDH1-C7orf60_BDH1_chr3_197273232_ENST00000392378_C7orf60_chr7_112472730_ENST00000297145_length(transcript)=3736nt_BP=394nt
GGAGGAGGCGGCTCGGCGGCCCCCCGACAGCCACGCCGCCGTGAGCCCCGCCCAGCGTAGCCCCAGCGCGCGCTTCGCGTGTAGAAGCGT
CCGGGTGGCGGAGGCCGCAGGCCGCAGGAGTGCTGGTGGAGGGGCTTCCAGAAAGACCCTGCGGCAGCGCCCCCCCTCGGCTCTCCCCGC
AGGAGAGCGGGCACCTGCGCGGCGCCGGGTGAAGGCGAGAGCCTCGGCGAGCCCTCTGCAGCGGAGCCCCCTGCCCATTTGGTTTTGGAA
CCACCGGGAGGAACTGGGCCATTCTAACACCCGTTGCTACCATGCTGGCCACCCGCCTCTCCAGACCCCTGTCACGGCTCCCAGGAAAAA
CCCTAAGTGCCTGTGATAGAGAAAATGGAGCAAGGTTGCTACAAGCCTCAGGAAAAATCAGATTACTTGATGTTGGCAGCTGCTTTAACC
CATTTCTGAAGTTTGAAGAATTTCTAACTGTTGGCATAGATATTGTACCTGCTGTAGAGAGTGTCTATAAATGTGATTTCCTGAACTTAC
AGCTTCAGCAACCACTCCAGCTTGCACAGGATGCTATAGATGCTTTTTTGAAGCAGCTGAAAAACCCTATTGATTCTCTTCCTGGAGAGC
TTTTCCATGTGGTTGTTTTCTCTCTCCTTCTTTCTTATTTTCCATCTCCTTACCAGCGATGGATTTGCTGCAAGAAAGCCCATGAACTGT
TAGTGTTAAATGGTTTATTACTAATCATCACACCTGATTCCTCCCATCAGAACCGTCATGCTATGATGATGAAAAGCTGGAAGATTGCTA
TAGAGTCCCTGGGCTTTAAACGCTTCAAGTACTCAAAATTTTCACATATGCATCTGATGGCATTTAGGAAAATCTCTCTAAAAACCACAA
GTGACTTGGTTAGTAGGAACTACCCAGGAATGTTATATATTCCTCAAGATTTCAACAGTATAGAAGATGAGGAATATTCTAACCCTTCCT
GCTATGTTCGATCAGATATAGAAGATGAACAACTAGCATATGGTTTCACAGAACTCCCTGATGCGCCATATGACTCAGATTCTGGAGAAA
GTCAAGCCAGCTCTATTCCTTTCTATGAGCTAGAAGACCCCATATTACTTTTAAGTTAATATAGAAGCAAAAAGCCCCTTTCAGTCCAGG
CTCCTAAACTAATTGCTTACACCAATTGGAAATACTAACATGAACTCAGTACTGAAAACCTGGTTTGCATAAAAGAAATGCAGAGGTTTA
CAGAGTTTGCTATTTTTTTCTACTTCTCAATTTTAAAATTTATTCTTATATAGAAAGCTTAAAGTTTCATGCAGAGTGACTCATGTCATA
GCAGAAACTACTGTTACTTTAGCATTTAGCACTATCATAGAAAGGTACCTTTTTCTCTTTAGTGCTATTGTGAAAACAAGCATAATTTGC
TATATGTTTTCCTTTTCAACTTTTCAGTGTTGACTATAAACCATTGAATGGAAAACTTTAAGATGTAGAAAGCTGTAGATTGCACTTTGA
TGACTCACAAGTTAAATGTGATACAGAAAAATAGATCGGTTAGTTGTTTTGTGATGCACTTATCTTTTTCTTTTTTCTAACTAAAATTGT
GATGTTACAGAAAGTCATTTTATGTTCCTTTTTTGTCTGATGATCCAATATTTACTGAACTTTTTGTAATTGGTGATAATTCTTTTTATT
TCTTCCTTATATTAAAAGCTCATTTGACAGCATCAGACATTGGGGGAGAGATGTCCCCCAAAGTGTGTATTCTAATTTTATTAGCCCTAT
CCAATAAACACCATTGCCAAAGTAGTATTTTCATAACTTTCTTGTTGATTTGGGCCTTGGTGTGAAGTATATTTACCTGAGAGTTCACTT
TTACTTTTCTTAAACTTAGGCTTCATTTACAAAATGTTTTATTTAAGCAAGGAACAATGTAATACTCAATAATGACCTAAAACACCTTTT
TGAAAGGGTTTGCACTTGGAAGAGAGTTTATGTTCTGTTGAAACCAACTTTGATAGGGTCCTCACCTTTCCGTTAAGGAGGTGCCGCACT
ACAAGTTTCAAATTATATGGAAAAACCTAAAATTAACCCTCTGTTGGTGATCTCATAAAATGGTTTTGACCTTTTGGTATCTTAATTTCT
ATCTAAACTTTATCAGAAAATTTTCTTTGAATATATCAATTAGTTGGCTGTGGGAATTTTCCCTTTCCACATTAATAAATGCCTTTCTGT
GTTTCTGAATCAGAAGCAAATGATTAGGGAAAAATATATGTCCAAACAAGACAAGATTAGTTTAAACAGTTAAGAACATTTAGTCCACAT
TGTCTTGTCAGCCAGCAATTGTCATGGAAGCTATCATTTTTAAGAGTGCCACTGTGTGGATTTTTTTTTCAAGTGGTTATTACATTAAAA
TTACCTCATACTGAGGTTTTTGCACTGAAATATCACAGTTTCAGATTTCATGGTTAATGTTGTGCGTATGTTTGTATGTTTTTAAAGGAA
ACTTGCATTTTCAATAGTTGATCCTAAATTTCATAAACTGCACTTCTTTACTCTGGTAAAGCTGATGTTTTTGTGCTTATTGTGAATTGC
CGTAGTACCTTTGAATGTCAAACTTTATTTAGAAATATAAAACTTATCCTTTATGATATAAATGGTTGAGTGTATGTACCCAGTATTTCT
AATTAAATTTCACATGCTAAATTAATGAAAGTAACAAGATTGTAATTTTTTAAAGTCAGTTGATTAAATGCAATAAATATTGGTTGCTCA
AATATGCCACAAATAACTCGAAATTTTTCATTTACTTTCAACAGCATAAGATTCTTTAATATTTAGGATTGACTGTTCTTTCCAGTTAAG
CACTGAAGGATTATGTCTTGTAGCTTCCCCAAGAGAAGGGGAAGGAAAAAAAAGCACTATGTTAAGGATAATACAGAACTCTTTTGAACT
ATTTTGGTAGTACCTTTTACCATACTGTTTGCTTTTTGATTTGGGTAAATATCTTAAGAGCAAAGAAAACAATACACCAAATGAAAATGC
TTTGAAAGTAAATGAAAACAGCGCTTTTGAAAGGCTGGTATAGTATGACCCTGGAGTCAGCCTTTGTGTTACAGCGAAAATGTTGGTGCT
ATAAATTCTGATTGTTTACAGATGTTGATTCTGCTTATGCTCCAAAGTGTGCATGATGTATTTTACGTAGTACTCTGAGGAAGTCTCTTT
ATAAAACCTACTACCACTTAGTATAAATTTGTTTGAATTTATATCATTTGTTACTGTAAATTCAGCTTATTCCAATTAGGTTGGCACAGA
TTTAAACTGATACACATTCCACAAAAACCAATTCAGTGTATAAGTATTGAAGTATAAGCAGTCATTGCAGCTTGATGCCAGATCATGTAT
GTAATAACAAGTGGAAGTTAATAGGGCCTTCTAATACTGTATGGGTACTCCTAAGAATTATTTCATTTTGGATATAAAGAAGTTATGAGG
CCTCCTGTCACATTCACAGCTGGTTCTCCAAAATAATTTGGTTGTTTCAAAAACAAATGGTAATCATTTGGTTGGATTCTTCAGTATCAT
GACTAGATCATGTGGTTTTACCATAGTTGCCAAGTGGTGGGAGGTAGCATACCTGAAAATGTACGTGTGTGTTTGTTGTATTTTTTCACA

>9554_9554_2_BDH1-C7orf60_BDH1_chr3_197273232_ENST00000392378_C7orf60_chr7_112472730_ENST00000297145_length(amino acids)=275AA_BP=27
MLATRLSRPLSRLPGKTLSACDRENGARLLQASGKIRLLDVGSCFNPFLKFEEFLTVGIDIVPAVESVYKCDFLNLQLQQPLQLAQDAID
AFLKQLKNPIDSLPGELFHVVVFSLLLSYFPSPYQRWICCKKAHELLVLNGLLLIITPDSSHQNRHAMMMKSWKIAIESLGFKRFKYSKF
SHMHLMAFRKISLKTTSDLVSRNYPGMLYIPQDFNSIEDEEYSNPSCYVRSDIEDEQLAYGFTELPDAPYDSDSGESQASSIPFYELEDP

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Fusion Gene PPI Analysis for BDH1-C7orf60


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BDH1-C7orf60


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BDH1-C7orf60


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBDH1C0023893Liver Cirrhosis, Experimental2CTD_human
HgeneBDH1C0019193Hepatitis, Toxic1CTD_human
HgeneBDH1C0860207Drug-Induced Liver Disease1CTD_human
HgeneBDH1C1262760Hepatitis, Drug-Induced1CTD_human
HgeneBDH1C3658290Drug-Induced Acute Liver Injury1CTD_human
HgeneBDH1C4277682Chemical and Drug Induced Liver Injury1CTD_human
HgeneBDH1C4279912Chemically-Induced Liver Toxicity1CTD_human