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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GALNT11-DPP6 (FusionGDB2 ID:HG63917TG1804)

Fusion Gene Summary for GALNT11-DPP6

check button Fusion gene summary
Fusion gene informationFusion gene name: GALNT11-DPP6
Fusion gene ID: hg63917tg1804
HgeneTgene
Gene symbol

GALNT11

DPP6

Gene ID

63917

1804

Gene namepolypeptide N-acetylgalactosaminyltransferase 11dipeptidyl peptidase like 6
SynonymsGALNAC-T11|GALNACT11DPL1|DPPX|MRD33|VF2
Cytomap('GALNT11')('DPP6')

7q36.1|7q36.1

7q36.2

Type of geneprotein-codingprotein-coding
Descriptionpolypeptide N-acetylgalactosaminyltransferase 11UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)polypeptide GalNAc transferase 11pp-GaNTase 11pdipeptidyl aminopeptidase-like protein 6DPP VIdipeptidyl aminopeptidase IV-related proteindipeptidyl peptidase IV-related proteindipeptidyl peptidase VIdipeptidyl-peptidase 6
Modification date2020031320200313
UniProtAcc

Q8NCW6

P42658

Ensembl transtripts involved in fusion geneENST00000482812, ENST00000452146, 
ENST00000430044, ENST00000320311, 
ENST00000415421, ENST00000422997, 
ENST00000434507, 
Fusion gene scores* DoF score14 X 8 X 9=100817 X 17 X 7=2023
# samples 1619
** MAII scorelog2(16/1008*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/2023*10)=-3.41242499622733
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GALNT11 [Title/Abstract] AND DPP6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGALNT11(151722969)-DPP6(154143299), # samples:1
Anticipated loss of major functional domain due to fusion event.GALNT11-DPP6 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
GALNT11-DPP6 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGALNT11

GO:0018243

protein O-linked glycosylation via threonine

24226769

TgeneDPP6

GO:1901379

regulation of potassium ion transmembrane transport

18364354



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-78-7143-01AGALNT11chr7

151722969

-DPP6chr7

154143299

+


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Fusion Gene ORF analysis for GALNT11-DPP6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000482812ENST00000332007GALNT11chr7

151722969

-DPP6chr7

154143299

+
3UTR-3CDSENST00000482812ENST00000377770GALNT11chr7

151722969

-DPP6chr7

154143299

+
3UTR-3CDSENST00000482812ENST00000404039GALNT11chr7

151722969

-DPP6chr7

154143299

+
3UTR-3CDSENST00000482812ENST00000406326GALNT11chr7

151722969

-DPP6chr7

154143299

+
3UTR-3UTRENST00000482812ENST00000427557GALNT11chr7

151722969

-DPP6chr7

154143299

+
3UTR-3UTRENST00000482812ENST00000496611GALNT11chr7

151722969

-DPP6chr7

154143299

+
5CDS-3UTRENST00000452146ENST00000427557GALNT11chr7

151722969

-DPP6chr7

154143299

+
5CDS-3UTRENST00000452146ENST00000496611GALNT11chr7

151722969

-DPP6chr7

154143299

+
5UTR-3CDSENST00000430044ENST00000332007GALNT11chr7

151722969

-DPP6chr7

154143299

+
5UTR-3CDSENST00000430044ENST00000377770GALNT11chr7

151722969

-DPP6chr7

154143299

+
5UTR-3CDSENST00000430044ENST00000404039GALNT11chr7

151722969

-DPP6chr7

154143299

+
5UTR-3CDSENST00000430044ENST00000406326GALNT11chr7

151722969

-DPP6chr7

154143299

+
5UTR-3UTRENST00000430044ENST00000427557GALNT11chr7

151722969

-DPP6chr7

154143299

+
5UTR-3UTRENST00000430044ENST00000496611GALNT11chr7

151722969

-DPP6chr7

154143299

+
Frame-shiftENST00000452146ENST00000332007GALNT11chr7

151722969

-DPP6chr7

154143299

+
Frame-shiftENST00000452146ENST00000377770GALNT11chr7

151722969

-DPP6chr7

154143299

+
Frame-shiftENST00000452146ENST00000404039GALNT11chr7

151722969

-DPP6chr7

154143299

+
Frame-shiftENST00000452146ENST00000406326GALNT11chr7

151722969

-DPP6chr7

154143299

+
intron-3CDSENST00000320311ENST00000332007GALNT11chr7

151722969

-DPP6chr7

154143299

+
intron-3CDSENST00000320311ENST00000377770GALNT11chr7

151722969

-DPP6chr7

154143299

+
intron-3CDSENST00000320311ENST00000404039GALNT11chr7

151722969

-DPP6chr7

154143299

+
intron-3CDSENST00000320311ENST00000406326GALNT11chr7

151722969

-DPP6chr7

154143299

+
intron-3CDSENST00000415421ENST00000332007GALNT11chr7

151722969

-DPP6chr7

154143299

+
intron-3CDSENST00000415421ENST00000377770GALNT11chr7

151722969

-DPP6chr7

154143299

+
intron-3CDSENST00000415421ENST00000404039GALNT11chr7

151722969

-DPP6chr7

154143299

+
intron-3CDSENST00000415421ENST00000406326GALNT11chr7

151722969

-DPP6chr7

154143299

+
intron-3CDSENST00000422997ENST00000332007GALNT11chr7

151722969

-DPP6chr7

154143299

+
intron-3CDSENST00000422997ENST00000377770GALNT11chr7

151722969

-DPP6chr7

154143299

+
intron-3CDSENST00000422997ENST00000404039GALNT11chr7

151722969

-DPP6chr7

154143299

+
intron-3CDSENST00000422997ENST00000406326GALNT11chr7

151722969

-DPP6chr7

154143299

+
intron-3CDSENST00000434507ENST00000332007GALNT11chr7

151722969

-DPP6chr7

154143299

+
intron-3CDSENST00000434507ENST00000377770GALNT11chr7

151722969

-DPP6chr7

154143299

+
intron-3CDSENST00000434507ENST00000404039GALNT11chr7

151722969

-DPP6chr7

154143299

+
intron-3CDSENST00000434507ENST00000406326GALNT11chr7

151722969

-DPP6chr7

154143299

+
intron-3UTRENST00000320311ENST00000427557GALNT11chr7

151722969

-DPP6chr7

154143299

+
intron-3UTRENST00000320311ENST00000496611GALNT11chr7

151722969

-DPP6chr7

154143299

+
intron-3UTRENST00000415421ENST00000427557GALNT11chr7

151722969

-DPP6chr7

154143299

+
intron-3UTRENST00000415421ENST00000496611GALNT11chr7

151722969

-DPP6chr7

154143299

+
intron-3UTRENST00000422997ENST00000427557GALNT11chr7

151722969

-DPP6chr7

154143299

+
intron-3UTRENST00000422997ENST00000496611GALNT11chr7

151722969

-DPP6chr7

154143299

+
intron-3UTRENST00000434507ENST00000427557GALNT11chr7

151722969

-DPP6chr7

154143299

+
intron-3UTRENST00000434507ENST00000496611GALNT11chr7

151722969

-DPP6chr7

154143299

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for GALNT11-DPP6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for GALNT11-DPP6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:151722969/:154143299)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GALNT11

Q8NCW6

DPP6

P42658

FUNCTION: Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward MUC1, MUC4, and EA2 than GALNT1. Not involved in glycosylation of erythropoietin (EPO). {ECO:0000269|PubMed:11925450, ECO:0000269|PubMed:24226769}.FUNCTION: Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437, PubMed:19441798). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:18364354). Has no dipeptidyl aminopeptidase activity (PubMed:8103397, PubMed:15476821). {ECO:0000269|PubMed:15454437, ECO:0000269|PubMed:18364354, ECO:0000269|PubMed:8103397, ECO:0000305|PubMed:15476821}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for GALNT11-DPP6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for GALNT11-DPP6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GALNT11-DPP6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GALNT11-DPP6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC1510586Autism Spectrum Disorders2CTD_human
TgeneC2751898Ventricular Fibrillation, Paroxysmal Familial, 12ORPHANET
TgeneC4017668VENTRICULAR FIBRILLATION DURING MYOCARDIAL INFARCTION, SUSCEPTIBILITY TO2ORPHANET
TgeneC0002736Amyotrophic Lateral Sclerosis1CTD_human
TgeneC0220693Microcephaly autosomal dominant1ORPHANET
TgeneC0393554Amyotrophic Lateral Sclerosis With Dementia1CTD_human
TgeneC0431350Primary microcephaly1GENOMICS_ENGLAND
TgeneC0543859Amyotrophic Lateral Sclerosis, Guam Form1CTD_human
TgeneC4225375MENTAL RETARDATION, AUTOSOMAL DOMINANT 331CTD_human;GENOMICS_ENGLAND;UNIPROT