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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:GALNT11-DPP6 (FusionGDB2 ID:HG63917TG1804) |
Fusion Gene Summary for GALNT11-DPP6 |
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Fusion gene information | Fusion gene name: GALNT11-DPP6 | Fusion gene ID: hg63917tg1804 | Hgene | Tgene | Gene symbol | GALNT11 | DPP6 | Gene ID | 63917 | 1804 |
Gene name | polypeptide N-acetylgalactosaminyltransferase 11 | dipeptidyl peptidase like 6 | |
Synonyms | GALNAC-T11|GALNACT11 | DPL1|DPPX|MRD33|VF2 | |
Cytomap | ('GALNT11')('DPP6') 7q36.1|7q36.1 | 7q36.2 | |
Type of gene | protein-coding | protein-coding | |
Description | polypeptide N-acetylgalactosaminyltransferase 11UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)polypeptide GalNAc transferase 11pp-GaNTase 11p | dipeptidyl aminopeptidase-like protein 6DPP VIdipeptidyl aminopeptidase IV-related proteindipeptidyl peptidase IV-related proteindipeptidyl peptidase VIdipeptidyl-peptidase 6 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q8NCW6 | P42658 | |
Ensembl transtripts involved in fusion gene | ENST00000482812, ENST00000452146, ENST00000430044, ENST00000320311, ENST00000415421, ENST00000422997, ENST00000434507, | ||
Fusion gene scores | * DoF score | 14 X 8 X 9=1008 | 17 X 17 X 7=2023 |
# samples | 16 | 19 | |
** MAII score | log2(16/1008*10)=-2.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(19/2023*10)=-3.41242499622733 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: GALNT11 [Title/Abstract] AND DPP6 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | GALNT11(151722969)-DPP6(154143299), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | GALNT11-DPP6 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. GALNT11-DPP6 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | GALNT11 | GO:0018243 | protein O-linked glycosylation via threonine | 24226769 |
Tgene | DPP6 | GO:1901379 | regulation of potassium ion transmembrane transport | 18364354 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | LUAD | TCGA-78-7143-01A | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
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Fusion Gene ORF analysis for GALNT11-DPP6 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000482812 | ENST00000332007 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
3UTR-3CDS | ENST00000482812 | ENST00000377770 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
3UTR-3CDS | ENST00000482812 | ENST00000404039 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
3UTR-3CDS | ENST00000482812 | ENST00000406326 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
3UTR-3UTR | ENST00000482812 | ENST00000427557 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
3UTR-3UTR | ENST00000482812 | ENST00000496611 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
5CDS-3UTR | ENST00000452146 | ENST00000427557 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
5CDS-3UTR | ENST00000452146 | ENST00000496611 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
5UTR-3CDS | ENST00000430044 | ENST00000332007 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
5UTR-3CDS | ENST00000430044 | ENST00000377770 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
5UTR-3CDS | ENST00000430044 | ENST00000404039 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
5UTR-3CDS | ENST00000430044 | ENST00000406326 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
5UTR-3UTR | ENST00000430044 | ENST00000427557 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
5UTR-3UTR | ENST00000430044 | ENST00000496611 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
Frame-shift | ENST00000452146 | ENST00000332007 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
Frame-shift | ENST00000452146 | ENST00000377770 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
Frame-shift | ENST00000452146 | ENST00000404039 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
Frame-shift | ENST00000452146 | ENST00000406326 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
intron-3CDS | ENST00000320311 | ENST00000332007 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
intron-3CDS | ENST00000320311 | ENST00000377770 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
intron-3CDS | ENST00000320311 | ENST00000404039 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
intron-3CDS | ENST00000320311 | ENST00000406326 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
intron-3CDS | ENST00000415421 | ENST00000332007 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
intron-3CDS | ENST00000415421 | ENST00000377770 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
intron-3CDS | ENST00000415421 | ENST00000404039 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
intron-3CDS | ENST00000415421 | ENST00000406326 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
intron-3CDS | ENST00000422997 | ENST00000332007 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
intron-3CDS | ENST00000422997 | ENST00000377770 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
intron-3CDS | ENST00000422997 | ENST00000404039 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
intron-3CDS | ENST00000422997 | ENST00000406326 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
intron-3CDS | ENST00000434507 | ENST00000332007 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
intron-3CDS | ENST00000434507 | ENST00000377770 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
intron-3CDS | ENST00000434507 | ENST00000404039 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
intron-3CDS | ENST00000434507 | ENST00000406326 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
intron-3UTR | ENST00000320311 | ENST00000427557 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
intron-3UTR | ENST00000320311 | ENST00000496611 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
intron-3UTR | ENST00000415421 | ENST00000427557 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
intron-3UTR | ENST00000415421 | ENST00000496611 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
intron-3UTR | ENST00000422997 | ENST00000427557 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
intron-3UTR | ENST00000422997 | ENST00000496611 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
intron-3UTR | ENST00000434507 | ENST00000427557 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
intron-3UTR | ENST00000434507 | ENST00000496611 | GALNT11 | chr7 | 151722969 | - | DPP6 | chr7 | 154143299 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for GALNT11-DPP6 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for GALNT11-DPP6 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:151722969/:154143299) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
GALNT11 | DPP6 |
FUNCTION: Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward MUC1, MUC4, and EA2 than GALNT1. Not involved in glycosylation of erythropoietin (EPO). {ECO:0000269|PubMed:11925450, ECO:0000269|PubMed:24226769}. | FUNCTION: Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437, PubMed:19441798). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:18364354). Has no dipeptidyl aminopeptidase activity (PubMed:8103397, PubMed:15476821). {ECO:0000269|PubMed:15454437, ECO:0000269|PubMed:18364354, ECO:0000269|PubMed:8103397, ECO:0000305|PubMed:15476821}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for GALNT11-DPP6 |
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Fusion Gene PPI Analysis for GALNT11-DPP6 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for GALNT11-DPP6 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for GALNT11-DPP6 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | C1510586 | Autism Spectrum Disorders | 2 | CTD_human | |
Tgene | C2751898 | Ventricular Fibrillation, Paroxysmal Familial, 1 | 2 | ORPHANET | |
Tgene | C4017668 | VENTRICULAR FIBRILLATION DURING MYOCARDIAL INFARCTION, SUSCEPTIBILITY TO | 2 | ORPHANET | |
Tgene | C0002736 | Amyotrophic Lateral Sclerosis | 1 | CTD_human | |
Tgene | C0220693 | Microcephaly autosomal dominant | 1 | ORPHANET | |
Tgene | C0393554 | Amyotrophic Lateral Sclerosis With Dementia | 1 | CTD_human | |
Tgene | C0431350 | Primary microcephaly | 1 | GENOMICS_ENGLAND | |
Tgene | C0543859 | Amyotrophic Lateral Sclerosis, Guam Form | 1 | CTD_human | |
Tgene | C4225375 | MENTAL RETARDATION, AUTOSOMAL DOMINANT 33 | 1 | CTD_human;GENOMICS_ENGLAND;UNIPROT |