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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Fusion gene:CDH23-NSD1 (FusionGDB2 ID:HG64072TG64324)

Fusion Gene Summary for CDH23-NSD1

check button Fusion gene summary
Fusion gene informationFusion gene name: CDH23-NSD1
Fusion gene ID: hg64072tg64324
HgeneTgene
Gene symbol

CDH23

NSD1

Gene ID

64072

64324

Gene namecadherin related 23nuclear receptor binding SET domain protein 1
SynonymsCDHR23|PITA5|USH1DARA267|KMT3B|SOTOS|SOTOS1|STO
Cytomap('CDH23')('NSD1')

10q22.1

5q35.3

Type of geneprotein-codingprotein-coding
Descriptioncadherin-23cadherin-like 23cadherin-related family member 23otocadherinhistone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specificH3-K36-HMTaseH4-K20-HMTaseNR-binding SET domain-containing proteinandrogen receptor coactivator 267 kDa proteinandrogen receptor-associated coregulator 267androgen receptor-as
Modification date2020032020200321
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000224721, ENST00000299366, 
ENST00000398788, ENST00000398809, 
ENST00000398842, ENST00000461841, 
ENST00000475158, 		ENST00000224721, 
ENST00000299366, ENST00000398788, 
ENST00000398809, ENST00000398842, 
ENST00000461841, ENST00000475158, 
Fusion gene scores* DoF score7 X 7 X 2=9812 X 14 X 7=1176
# samples 717
** MAII scorelog2(7/98*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1176*10)=-2.79028140869866
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CDH23 [Title/Abstract] AND NSD1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCDH23(73501678)-NSD1(176618885), # samples:2
Anticipated loss of major functional domain due to fusion event.CDH23-NSD1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDH23-NSD1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDH23-NSD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CDH23-NSD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNSD1

GO:0045893

positive regulation of transcription, DNA-templated

11509567


check buttonFusion gene breakpoints across CDH23 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across NSD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AN-A0FJ-01ACDH23chr10

73501678

-NSD1chr5

176618885

+
ChimerDB4BRCATCGA-AN-A0FJ-01ACDH23chr10

73501678

+NSD1chr5

176618885

+


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Fusion Gene ORF analysis for CDH23-NSD1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000224721ENST00000361032CDH23chr10

73501678

+NSD1chr5

176618885

+
5CDS-intronENST00000224721ENST00000511258CDH23chr10

73501678

+NSD1chr5

176618885

+
In-frameENST00000224721ENST00000347982CDH23chr10

73501678

+NSD1chr5

176618885

+
In-frameENST00000224721ENST00000354179CDH23chr10

73501678

+NSD1chr5

176618885

+
In-frameENST00000224721ENST00000439151CDH23chr10

73501678

+NSD1chr5

176618885

+
intron-3CDSENST00000299366ENST00000347982CDH23chr10

73501678

+NSD1chr5

176618885

+
intron-3CDSENST00000299366ENST00000354179CDH23chr10

73501678

+NSD1chr5

176618885

+
intron-3CDSENST00000299366ENST00000439151CDH23chr10

73501678

+NSD1chr5

176618885

+
intron-3CDSENST00000398788ENST00000347982CDH23chr10

73501678

+NSD1chr5

176618885

+
intron-3CDSENST00000398788ENST00000354179CDH23chr10

73501678

+NSD1chr5

176618885

+
intron-3CDSENST00000398788ENST00000439151CDH23chr10

73501678

+NSD1chr5

176618885

+
intron-3CDSENST00000398809ENST00000347982CDH23chr10

73501678

+NSD1chr5

176618885

+
intron-3CDSENST00000398809ENST00000354179CDH23chr10

73501678

+NSD1chr5

176618885

+
intron-3CDSENST00000398809ENST00000439151CDH23chr10

73501678

+NSD1chr5

176618885

+
intron-3CDSENST00000398842ENST00000347982CDH23chr10

73501678

+NSD1chr5

176618885

+
intron-3CDSENST00000398842ENST00000354179CDH23chr10

73501678

+NSD1chr5

176618885

+
intron-3CDSENST00000398842ENST00000439151CDH23chr10

73501678

+NSD1chr5

176618885

+
intron-3CDSENST00000461841ENST00000347982CDH23chr10

73501678

+NSD1chr5

176618885

+
intron-3CDSENST00000461841ENST00000354179CDH23chr10

73501678

+NSD1chr5

176618885

+
intron-3CDSENST00000461841ENST00000439151CDH23chr10

73501678

+NSD1chr5

176618885

+
intron-3CDSENST00000475158ENST00000347982CDH23chr10

73501678

+NSD1chr5

176618885

+
intron-3CDSENST00000475158ENST00000354179CDH23chr10

73501678

+NSD1chr5

176618885

+
intron-3CDSENST00000475158ENST00000439151CDH23chr10

73501678

+NSD1chr5

176618885

+
intron-intronENST00000299366ENST00000361032CDH23chr10

73501678

+NSD1chr5

176618885

+
intron-intronENST00000299366ENST00000511258CDH23chr10

73501678

+NSD1chr5

176618885

+
intron-intronENST00000398788ENST00000361032CDH23chr10

73501678

+NSD1chr5

176618885

+
intron-intronENST00000398788ENST00000511258CDH23chr10

73501678

+NSD1chr5

176618885

+
intron-intronENST00000398809ENST00000361032CDH23chr10

73501678

+NSD1chr5

176618885

+
intron-intronENST00000398809ENST00000511258CDH23chr10

73501678

+NSD1chr5

176618885

+
intron-intronENST00000398842ENST00000361032CDH23chr10

73501678

+NSD1chr5

176618885

+
intron-intronENST00000398842ENST00000511258CDH23chr10

73501678

+NSD1chr5

176618885

+
intron-intronENST00000461841ENST00000361032CDH23chr10

73501678

+NSD1chr5

176618885

+
intron-intronENST00000461841ENST00000511258CDH23chr10

73501678

+NSD1chr5

176618885

+
intron-intronENST00000475158ENST00000361032CDH23chr10

73501678

+NSD1chr5

176618885

+
intron-intronENST00000475158ENST00000511258CDH23chr10

73501678

+NSD1chr5

176618885

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000224721CDH23chr1073501678+ENST00000354179NSD1chr5176618885+1678048655120284007
ENST00000224721CDH23chr1073501678+ENST00000439151NSD1chr5176618885+1678548655120284007
ENST00000224721CDH23chr1073501678+ENST00000347982NSD1chr5176618885+1233248655120284007

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000224721ENST00000354179CDH23chr1073501678+NSD1chr5176618885+0.0002619530.99973804
ENST00000224721ENST00000439151CDH23chr1073501678+NSD1chr5176618885+0.0002619960.99973804
ENST00000224721ENST00000347982CDH23chr1073501678+NSD1chr5176618885+0.0005037950.9994962

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Fusion Genomic Features for CDH23-NSD1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CDH23chr1073501678+NSD1chr5176618884+3.67E-121
CDH23chr1073501678+NSD1chr5176618884+3.67E-121

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CDH23-NSD1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:73501678/chr5:176618885)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNSD1chr10:73501678chr5:176618885ENST000003479822242207_2421402428.0Compositional biasNote=Pro-rich
TgeneNSD1chr10:73501678chr5:176618885ENST000003541792242207_2421402428.0Compositional biasNote=Pro-rich
TgeneNSD1chr10:73501678chr5:176618885ENST000003610320202207_242102594.0Compositional biasNote=Pro-rich
TgeneNSD1chr10:73501678chr5:176618885ENST000004391511232207_24213092697.0Compositional biasNote=Pro-rich
TgeneNSD1chr10:73501678chr5:176618885ENST000003479822241756_1818402428.0DomainPWWP 2
TgeneNSD1chr10:73501678chr5:176618885ENST000003479822241890_1940402428.0DomainAWS
TgeneNSD1chr10:73501678chr5:176618885ENST000003479822241942_2059402428.0DomainSET
TgeneNSD1chr10:73501678chr5:176618885ENST000003479822242066_2082402428.0DomainPost-SET
TgeneNSD1chr10:73501678chr5:176618885ENST00000347982224323_388402428.0DomainPWWP 1
TgeneNSD1chr10:73501678chr5:176618885ENST000003541792241756_1818402428.0DomainPWWP 2
TgeneNSD1chr10:73501678chr5:176618885ENST000003541792241890_1940402428.0DomainAWS
TgeneNSD1chr10:73501678chr5:176618885ENST000003541792241942_2059402428.0DomainSET
TgeneNSD1chr10:73501678chr5:176618885ENST000003541792242066_2082402428.0DomainPost-SET
TgeneNSD1chr10:73501678chr5:176618885ENST00000354179224323_388402428.0DomainPWWP 1
TgeneNSD1chr10:73501678chr5:176618885ENST000003610320201756_181802594.0DomainPWWP 2
TgeneNSD1chr10:73501678chr5:176618885ENST000003610320201890_194002594.0DomainAWS
TgeneNSD1chr10:73501678chr5:176618885ENST000003610320201942_205902594.0DomainSET
TgeneNSD1chr10:73501678chr5:176618885ENST000003610320202066_208202594.0DomainPost-SET
TgeneNSD1chr10:73501678chr5:176618885ENST00000361032020323_38802594.0DomainPWWP 1
TgeneNSD1chr10:73501678chr5:176618885ENST000004391511231756_18183092697.0DomainPWWP 2
TgeneNSD1chr10:73501678chr5:176618885ENST000004391511231890_19403092697.0DomainAWS
TgeneNSD1chr10:73501678chr5:176618885ENST000004391511231942_20593092697.0DomainSET
TgeneNSD1chr10:73501678chr5:176618885ENST000004391511232066_20823092697.0DomainPost-SET
TgeneNSD1chr10:73501678chr5:176618885ENST00000439151123323_3883092697.0DomainPWWP 1
TgeneNSD1chr10:73501678chr5:176618885ENST000003479822241952_1954402428.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr10:73501678chr5:176618885ENST000003479822241994_1997402428.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr10:73501678chr5:176618885ENST000003479822242020_2021402428.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr10:73501678chr5:176618885ENST000003479822242060_2066402428.0RegionNote=Inhibits enzyme activity in the absence of bound histone
TgeneNSD1chr10:73501678chr5:176618885ENST000003541792241952_1954402428.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr10:73501678chr5:176618885ENST000003541792241994_1997402428.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr10:73501678chr5:176618885ENST000003541792242020_2021402428.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr10:73501678chr5:176618885ENST000003541792242060_2066402428.0RegionNote=Inhibits enzyme activity in the absence of bound histone
TgeneNSD1chr10:73501678chr5:176618885ENST000003610320201952_195402594.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr10:73501678chr5:176618885ENST000003610320201994_199702594.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr10:73501678chr5:176618885ENST000003610320202020_202102594.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr10:73501678chr5:176618885ENST000003610320202060_206602594.0RegionNote=Inhibits enzyme activity in the absence of bound histone
TgeneNSD1chr10:73501678chr5:176618885ENST000004391511231952_19543092697.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr10:73501678chr5:176618885ENST000004391511231994_19973092697.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr10:73501678chr5:176618885ENST000004391511232020_20213092697.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr10:73501678chr5:176618885ENST000004391511232060_20663092697.0RegionNote=Inhibits enzyme activity in the absence of bound histone
TgeneNSD1chr10:73501678chr5:176618885ENST000003479822241543_1589402428.0Zinc fingerPHD-type 1
TgeneNSD1chr10:73501678chr5:176618885ENST000003479822241590_1646402428.0Zinc fingerPHD-type 2
TgeneNSD1chr10:73501678chr5:176618885ENST000003479822241707_1751402428.0Zinc fingerPHD-type 3
TgeneNSD1chr10:73501678chr5:176618885ENST000003479822242118_2165402428.0Zinc fingerPHD-type 4%3B atypical
TgeneNSD1chr10:73501678chr5:176618885ENST000003541792241543_1589402428.0Zinc fingerPHD-type 1
TgeneNSD1chr10:73501678chr5:176618885ENST000003541792241590_1646402428.0Zinc fingerPHD-type 2
TgeneNSD1chr10:73501678chr5:176618885ENST000003541792241707_1751402428.0Zinc fingerPHD-type 3
TgeneNSD1chr10:73501678chr5:176618885ENST000003541792242118_2165402428.0Zinc fingerPHD-type 4%3B atypical
TgeneNSD1chr10:73501678chr5:176618885ENST000003610320201543_158902594.0Zinc fingerPHD-type 1
TgeneNSD1chr10:73501678chr5:176618885ENST000003610320201590_164602594.0Zinc fingerPHD-type 2
TgeneNSD1chr10:73501678chr5:176618885ENST000003610320201707_175102594.0Zinc fingerPHD-type 3
TgeneNSD1chr10:73501678chr5:176618885ENST000003610320202118_216502594.0Zinc fingerPHD-type 4%3B atypical
TgeneNSD1chr10:73501678chr5:176618885ENST000004391511231543_15893092697.0Zinc fingerPHD-type 1
TgeneNSD1chr10:73501678chr5:176618885ENST000004391511231590_16463092697.0Zinc fingerPHD-type 2
TgeneNSD1chr10:73501678chr5:176618885ENST000004391511231707_17513092697.0Zinc fingerPHD-type 3
TgeneNSD1chr10:73501678chr5:176618885ENST000004391511232118_21653092697.0Zinc fingerPHD-type 4%3B atypical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+1231103_120801115.0DomainCadherin 11
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+1231210_131301115.0DomainCadherin 12
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+1231314_141801115.0DomainCadherin 13
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+123133_23601115.0DomainCadherin 2
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+1231420_152701115.0DomainCadherin 14
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+1231529_163401115.0DomainCadherin 15
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+1231635_174401115.0DomainCadherin 16
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+1231745_185101115.0DomainCadherin 17
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+1231852_195901115.0DomainCadherin 18
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+1231960_206901115.0DomainCadherin 19
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+1232070_217401115.0DomainCadherin 20
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+1232175_229301115.0DomainCadherin 21
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+1232297_240201115.0DomainCadherin 22
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+123237_34801115.0DomainCadherin 3
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+1232403_250901115.0DomainCadherin 23
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+1232510_261101115.0DomainCadherin 24
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+1232614_272201115.0DomainCadherin 25
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+1232729_284601115.0DomainCadherin 26
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+1232847_297501115.0DomainCadherin 27
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+123349_46001115.0DomainCadherin 4
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+12334_13201115.0DomainCadherin 1
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+123461_56101115.0DomainCadherin 5
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+123562_67101115.0DomainCadherin 6
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+123672_78401115.0DomainCadherin 7
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+123779_89001115.0DomainCadherin 8
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+123891_99501115.0DomainCadherin 9
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+123996_110201115.0DomainCadherin 10
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+1141103_12080531.0DomainCadherin 11
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+1141210_13130531.0DomainCadherin 12
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+1141314_14180531.0DomainCadherin 13
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+114133_2360531.0DomainCadherin 2
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+1141420_15270531.0DomainCadherin 14
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+1141529_16340531.0DomainCadherin 15
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+1141635_17440531.0DomainCadherin 16
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+1141745_18510531.0DomainCadherin 17
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+1141852_19590531.0DomainCadherin 18
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+1141960_20690531.0DomainCadherin 19
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+1142070_21740531.0DomainCadherin 20
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+1142175_22930531.0DomainCadherin 21
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+1142297_24020531.0DomainCadherin 22
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+114237_3480531.0DomainCadherin 3
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+1142403_25090531.0DomainCadherin 23
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+1142510_26110531.0DomainCadherin 24
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+1142614_27220531.0DomainCadherin 25
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+1142729_28460531.0DomainCadherin 26
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+1142847_29750531.0DomainCadherin 27
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+114349_4600531.0DomainCadherin 4
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+11434_1320531.0DomainCadherin 1
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+114461_5610531.0DomainCadherin 5
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+114562_6710531.0DomainCadherin 6
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+114672_7840531.0DomainCadherin 7
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+114779_8900531.0DomainCadherin 8
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+114891_9950531.0DomainCadherin 9
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+114996_11020531.0DomainCadherin 10
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+12324_306401115.0Topological domainExtracellular
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+1233086_335401115.0Topological domainCytoplasmic
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+11424_30640531.0Topological domainExtracellular
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+1143086_33540531.0Topological domainCytoplasmic
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+1233065_308501115.0TransmembraneHelical
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+1143065_30850531.0TransmembraneHelical


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Fusion Gene Sequence for CDH23-NSD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>15062_15062_1_CDH23-NSD1_CDH23_chr10_73501678_ENST00000224721_NSD1_chr5_176618885_ENST00000347982_length(transcript)=12332nt_BP=4865nt
GAGCCATGGGGCGCCATGTTGCCACCAGCTGCCACGTGGCCTGGCTTTTGGTGCTGATCTCTGGATGCTGGGGCCAGGTGAACCGGCTGC
CCTTCTTCACCAACCACTTCTTTGATACATACCTGCTGATCAGCGAGGACACGCCTGTGGGTTCTTCTGTGACCCAGTTGCTGGCCCAAG
ACATGGACAATGACCCCCTGGTGTTTGGCGTGTCTGGGGAGGAGGCCTCTCGCTTCTTTGCAGTGGAGCCTGACACTGGCGTGGTGTGGC
TCCGGCAGCCACTGGACAGAGAGACCAAGTCAGAGTTCACCGTGGAGTTCTCTGTCAGCGACCACCAGGGGGTGATCACACGGAAGGTGA
ACATCCAGGTTGGGGATGTGAATGACAACGCGCCCACATTTCACAATCAGCCCTACAGCGTCCGCATCCCTGAGGTAGGAGCCACTGGGA
ATACACCAGTGGGGACGCCCATCTTCATCGTGAATGCCACAGACCCCGACTTGGGGGCAGGGGGCAGCGTCCTCTACTCCTTCCAGCCCC
CCTCCCAATTCTTCGCCATTGACAGCGCCCGCGGTATCGTCACAGTGATCCGGGAGCTGGACTACGAGACCACACAGGCCTACCAGCTCA
CGGTCAACGCCACAGATCAAGACAAGACCAGGCCTCTGTCCACCCTGGCCAACTTGGCCATCATCATCACAGATGTCCAGGACATGGACC
CCATCTTCATCAACCTGCCTTACAGCACCAACATCTACGAGCATTCTCCTCCGGGCACGACGGTGCGCATCATCACCGCCATAGACCAGG
ATAAAGGACGTCCCCGGGGCATTGGCTACACCATCGTTTCAGGGAATACCAACAGCATCTTTGCCCTGGACTACATCAGCGGAGTGCTGA
CCTTGAATGGCCTGCTGGACCGGGAGAACCCCCTGTACAGCCATGGCTTCATCCTGACTGTGAAGGGCACGGAGCTGAACGATGACCGCA
CCCCATCTGACGCTACAGTCACCACGACCTTCAATATCCTGGTTATTGACATCAATGACAATGCCCCGGAGTTCAACAGCTCCGAGTACA
GCGTGGCCATCACTGAGCTGGCACAGGTCGGCTTTGCCCTTCCACTCTTCATCCAGGTGGTGGACAAGGATGAGAATTTGGGCCTGAACA
GCATGTTTGAGGTGTACTTGGTGGGGAACAACTCCCACCACTTCATCATCTCCCCGACCTCCGTCCAGGGGAAGGCGGACATTCGTATTC
GGGTGGCCATCCCACTGGACTACGAGACCGTGGACCGCTACGACTTTGATCTCTTTGCCAATGAGAGTGTGCCTGACCATGTGGGCTATG
CCAAGGTGAAGATCACTCTCATCAATGAAAATGACAACCGGCCCATCTTCAGCCAGCCACTGTACAACATCAGCCTGTACGAGAACGTCA
CCGTGGGGACCTCTGTGCTGACAGTCCTGGCAACTGACAATGATGCAGGCACCTTTGGGGAAGTCAGCTACTTCTTCAGTGATGACCCTG
ACAGGTTCTCGCTGGACAAGGACACGGGACTCATCATGCTGATTGCCAGGCTGGACTATGAGCTCATCCAGCGCTTCACCCTGACGATCA
TTGCCCGGGACGGGGGCGGCGAGGAGACCACAGGCCGGGTCAGGATCAATGTGTTGGATGTCAACGACAACGTGCCCACCTTCCAGAAGG
ATGCCTACGTGGGTGCTCTGCGGGAGAACGAGCCTTCTGTCACACAGCTGGTGCGGCTCCGGGCAACAGATGAAGACTCCCCTCCCAACA
ACCAGATCACCTACAGCATTGTCAGTGCATCTGCCTTTGGCAGCTACTTCGACATCAGCCTGTACGAGGGCTATGGAGTGATCAGCGTCA
GTCGCCCCCTGGATTATGAACAGATATCCAATGGGCTGATTTATCTGACGGTCATGGCCATGGATGCTGGCAACCCCCCTCTCAACAGCA
CCGTCCCTGTCACCATCGAGGTGTTTGATGAGAATGACAACCCTCCCACCTTCAGCAAGCCCGCCTACTTCGTCTCCGTGGTGGAGAACA
TCATGGCAGGAGCCACGGTGCTGTTCCTGAATGCCACAGACCTGGACCGCTCCCGGGAGTACGGCCAGGAGTCCATCATCTACTCCTTGG
AAGGCTCCACCCAGTTTCGGATCAATGCCCGCTCAGGGGAAATCACCACCACGTCTCTGCTTGACCGAGAGACCAAGTCTGAATACATCC
TCATCGTTCGCGCAGTGGACGGGGGTGTGGGCCACAACCAGAAAACTGGCATCGCCACCGTAAACATCACCCTCCTGGACATCAATGACA
ACCACCCCACGTGGAAGGACGCACCCTACTACATCAACCTGGTGGAGATGACCCCTCCAGACTCTGATGTGACCACGGTGGTGGCTGTTG
ACCCAGACCTGGGGGAGAATGGCACCCTGGTGTACAGCATCCAGCCACCCAACAAGTTCTACAGCCTCAACAGCACCACGGGCAAGATCC
GCACCACCCACGCCATGCTGGACCGGGAGAACCCCGACCCCCATGAGGCCGAGCTGATGCGCAAAATCGTCGTCTCTGTTACTGACTGTG
GCAGGCCCCCTCTGAAAGCCACCAGCAGTGCCACAGTGTTTGTGAACCTCTTGGATCTCAATGACAATGACCCCACCTTTCAGAACCTGC
CTTTTGTGGCCGAGGTGCTTGAAGGCATCCCGGCGGGGGTCTCCATCTACCAAGTGGTGGCCATCGACCTCGATGAGGGCCTGAACGGCC
TGGTGTCCTACCGCATGCCGGTGGGCATGCCCCGCATGGACTTCCTCATCAACAGCAGCAGCGGCGTGGTGGTCACCACCACCGAGCTGG
ACCGCGAGCGCATCGCGGAGTACCAGCTGCGGGTGGTGGCCAGTGATGCAGGCACGCCCACCAAGAGCTCCACCAGCACGCTCACCATCC
ATGTGCTGGATGTGAACGACGAGACGCCCACCTTCTTCCCGGCCGTGTACAATGTGTCTGTGTCCGAGGACGTGCCACGCGAGTTCCGGG
TGGTCTGGCTGAACTGCACGGACAACGACGTGGGCCTCAATGCAGAGCTCAGCTACTTCATCACAGGTGGCAACGTGGATGGGAAGTTCA
GCGTGGGTTACCGCGATGCCGTTGTGAGAACCGTGGTGGGCCTGGACCGGGAGACCACAGCCGCCTACATGCTCATCCTGGAGGCCATCG
ACAACGGCCCTGTAGGGAAGCGACACACGGGCACAGCCACCGTGTTCGTCACTGTCCTGGATGTGAATGACAACCGGCCCATCTTTCTGC
AGAGCAGCTATGAGGCCAGCGTCCCTGAGGACATCCCTGAAGGCCACAGCATCTTGCAGCTGAAAGCCACGGACGCAGATGAGGGCGAGT
TTGGGCGTGTGTGGTACCGCATCCTCCATGGTAACCATGGCAACAACTTCCGGATCCATGTCAGCAATGGGCTCCTGATGCGAGGGCCCC
GGCCCCTGGACCGGGAGCGGAACTCATCCCACGTGCTGATAGTGGAGGCCTACAACCACGACCTGGGCCCCATGCGGAGCTCCGTCAGGG
TGATTGTGTACGTGGAGGACATCAACGATGAGGCCCCCGTGTTCACACAGCAGCAGTACAGCCGTCTGGGGCTTCGAGAGACCGCAGGCA
TTGGAACGTCAGTCATCGTGGTCCAAGCCACAGACCGAGACTCTGGGGATGGTGGCCTGGTGAACTACCGCATCCTGTCGGGCGCAGAGG
GGAAGTTTGAGATTGACGAGAGCACAGGGCTTATCATCACCGTGAATTACCTGGACTACGAGACCAAGACCAGCTACATGATGAATGTGT
CGGCCACTGACCAGGCCCCGCCCTTCAACCAGGGCTTCTGCAGCGTCTACATCACTCTGCTCAACGAGCTGGACGAGGCCGTGCAGTTCT
CCAATGCCTCATACGAGGCTGCCATCCTGGAGAATCTGGCACTGGGTACTGAGATTGTGCGGGTCCAGGCCTACTCCATCGACAACCTCA
ACCAAATCACGTACCGCTTCAACGCCTACACCAGCACCCAGGCCAAAGCCCTCTTCAAGATAGACGCCATCACGGGTGTGATCACAGTCC
AGGGCCTGGTGGACCGTGAGAAGGGCGACTTCTATACCTTGACAGTGGTGGCAGATGACGGCGGCCCCAAGGTGGACTCCACCGTGAAGG
TCTACATCACTGTGCTGGACGAGAATGACAACAGCCCCCGGTTTGACTTCACCTCCGACTCGGCGGTCAGCATACCCGAGGACTGCCCTG
TGGGCCAGCGAGTGGCTACTGTCAAGGCCTGGGACCCTGATGCTGGCAGCAATGGGCAGGTGGTCTTCTCCCTGGCCTCTGGCAACATCG
CGGGGGCCTTTGAGATCGTCACCACCAATGACTCCATTGGCGAAGTGTTTGTGGCCAGGCCCCTGGACAGAGAAGAGCTGGATCACTACA
TCCTCCAGGTTGTGGCTTCTGACCGAGGCACCCCTCCACGGAAGAAGGACCACATCCTGCAGGTGACCATCCTGGACATCAATGACAACC
CTCCAGTCATCGAGAGCCCCTTTGGATACAATGTCAGTGTGAATGAGAACGTGGGTGGAGGTACTGCTGTGGTCCAGGTGAGAGCCACTG
ACCGTGACATCGGGATCAACAGTGTTCTGTCCTACTACATCACCGAGGGCAACAAGGACATGGCCTTCCGCATGGACCGCATCAGCGGTG
AGATCGCCACACGGCCTGCCCCGCCTGACCGCGAGCGCCAGAGCTTCTACCACCTGGTGGCCACTGTGGAGGACGAGGGCACCCCAACCC
TGTCGTGTCAACCTAAGAAAAAGTCTACGCCACTGAAGTATGAAGTTGGAGATCTCATCTGGGCAAAATTCAAGAGACGCCCATGGTGGC
CCTGCAGGATTTGTTCTGATCCGTTGATTAACACACATTCAAAAATGAAAGTTTCCAACCGGAGGCCCTATCGGCAGTACTACGTGGAGG
CTTTTGGAGATCCTTCTGAGAGAGCCTGGGTGGCTGGAAAAGCAATCGTCATGTTTGAAGGCAGACATCAATTCGAAGAGCTACCTGTCC
TTAGGAGAAGAGGGAAACAGAAAGAAAAAGGATATAGGCATAAGGTTCCTCAGAAAATTTTGAGTAAATGGGAAGCCAGTGTTGGACTTG
CAGAACAGTATGATGTTCCCAAGGGGTCAAAGAACCGAAAATGTATTCCTGGTTCAATCAAGTTGGACAGTGAAGAAGATATGCCATTTG
AAGACTGCACAAATGATCCTGAGTCAGAACATGACCTGTTGCTTAATGGCTGTTTGAAATCACTGGCTTTTGATTCTGAACATTCTGCAG
ATGAGAAGGAAAAGCCTTGCGCTAAATCTCGAGCCAGAAAGAGCTCTGATAATCCAAAAAGGACTAGTGTGAAAAAGGGCCACATACAAT
TTGAAGCACATAAAGATGAACGGAGGGGAAAGATTCCAGAGAACCTTGGCCTAAACTTTATCTCTGGGGATATATCTGATACGCAGGCCT
CTAATGAACTTTCCAGGATAGCAAATAGCCTCACAGGGTCCAACACTGCCCCAGGAAGTTTTCTGTTTTCTTCCTGTGGAAAAAACACTG
CAAAGAAAGAATTTGAGACTTCAAATGGTGACTCTTTATTGGGCTTGCCTGAGGGTGCTTTGATCTCAAAGTGTTCTCGAGAGAAGAATA
AACCCCAACGAAGCCTGGTGTGTGGTTCAAAAGTGAAGCTCTGCTATATTGGAGCAGGTGATGAGGAAAAGCGAAGTGATTCCATTAGTA
TCTGTACCACTTCTGATGATGGAAGCAGTGACCTGGATCCCATAGAACACAGCTCAGAGTCTGATAACAGTGTCCTTGAAATTCCAGATG
CTTTCGATAGAACAGAGAACATGTTATCTATGCAGAAAAATGAAAAGATAAAGTATTCTAGGTTTGCTGCCACAAACACTAGGGTAAAAG
CAAAACAGAAGCCTCTCATTAGTAACTCACATACAGACCACTTAATGGGTTGTACTAAGAGTGCAGAGCCTGGAACCGAGACGTCTCAGG
TTAATCTCTCTGATCTGAAGGCATCTACTCTTGTTCACAAACCCCAGTCAGATTTTACAAATGATGCTCTCTCTCCAAAATTCAACCTGT
CATCAAGCATATCCAGTGAGAACTCGTTAATAAAGGGTGGGGCAGCAAATCAAGCTCTATTACATTCGAAAAGCAAACAGCCCAAGTTCC
GAAGTATAAAGTGCAAACACAAAGAAAATCCAGTTATGGCAGAACCCCCAGTTATAAATGAGGAGTGCAGTTTGAAATGCTGCTCTTCTG
ATACCAAAGGCTCTCCTTTGGCCAGCATTTCTAAAAGTGGGAAAGTGGATGGTCTAAAACTACTGAACAATATGCATGAGAAAACCAGGG
ATTCAAGTGACATAGAAACAGCAGTGGTGAAACATGTTTTATCCGAGTTGAAGGAACTCTCTTACAGATCCTTAGGTGAGGATGTCAGTG
ACTCTGGAACATCAAAGCCATCAAAACCATTACTTTTCTCTTCTGCTTCTAGTCAGAATCACATACCTATTGAACCAGACTACAAATTCA
GTACATTGCTAATGATGTTGAAAGATATGCATGATAGTAAGACGAAGGAGCAGCGGTTGATGACTGCTCAAAACCTGGTCTCTTACCGGA
GTCCTGGTCGTGGGGACTGTTCTACTAATAGTCCTGTAGGAGTCTCTAAGGTTTTGGTTTCAGGAGGCTCCACACACAATTCAGAGAAAA
AGGGAGATGGCACTCAGAACTCCGCCAATCCTAGCCCTAGTGGGGGTGACTCTGCATTATCTGGCGAGTTGTCTGCTTCCCTACCTGGCT
TACTGTCCGACAAGAGAGACCTCCCTGCTTCTGGTAAAAGTCGTTCAGACTGTGTTACTAGGCGCAACTGTGGACGATCAAAGCCTTCAT
CCAAATTGCGAGATGCTTTTTCAGCCCAAATGGTAAAGAACACAGTGAACCGTAAAGCCTTAAAGACCGAGCGCAAAAGAAAACTGAATC
AGCTTCCAAGTGTGACTCTTGATGCTGTACTGCAGGGAGACCGAGAACGTGGAGGTTCATTGAGAGGTGGGGCAGAAGATCCTAGTAAAG
AGGATCCCCTTCAGATAATGGGCCACTTAACAAGTGAAGATGGTGACCATTTTTCTGATGTGCATTTCGATAGCAAGGTTAAGCAATCTG
ATCCTGGTAAAATTTCTGAAAAAGGACTCTCTTTTGAAAACGGAAAAGGCCCAGAGCTGGACTCTGTAATGAACAGTGAGAATGATGAAC
TCAATGGTGTAAATCAAGTGGTGCCTAAAAAGCGGTGGCAGCGTTTAAACCAAAGGCGCACTAAACCTCGTAAGCGCATGAACAGATTTA
AAGAGAAAGAAAACTCTGAGTGTGCCTTTAGGGTCTTACTTCCTAGTGACCCTGTGCAGGAGGGGCGGGATGAGTTTCCAGAGCATAGAA
CTCCTTCAGCAAGCATACTTGAGGAACCACTGACAGAGCAAAATCATGCTGACTGCTTAGATTCAGCTGGGCCACGGTTAAATGTTTGTG
ATAAATCCAGTGCCAGCATTGGTGACATGGAAAAGGAGCCAGGAATTCCCAGTTTGACACCACAGGCTGAGCTCCCTGAACCAGCTGTGC
GGTCAGAGAAGAAACGCCTTAGGAAGCCAAGCAAGTGGCTTTTGGAATATACAGAAGAATATGATCAGATATTTGCTCCTAAGAAAAAAC
AAAAGAAGGTACAGGAGCAGGTGCACAAGGTAAGTTCCCGCTGTGAAGAGGAAAGCCTTCTAGCCCGAGGTCGATCTAGTGCTCAGAACA
AGCAGGTGGACGAGAATTCTTTGATTTCAACCAAAGAAGAGCCTCCAGTTCTTGAAAGGGAGGCTCCGTTTTTGGAGGGCCCCTTGGCTC
AGTCAGAACTTGGAGGTGGACATGCTGAGTTGCCGCAGCTGACCTTGTCTGTGCCTGTGGCTCCGGAAGTCTCTCCACGGCCTGCCCTTG
AGTCTGAGGAATTGCTAGTTAAAACGCCAGGAAATTATGAAAGTAAACGTCAAAGAAAACCAACTAAGAAACTTCTTGAATCCAATGATT
TAGACCCTGGATTTATGCCCAAGAAGGGGGACCTTGGCCTTTCTAAAAAGTGCTATGAAGCTGGTCACCTGGAGAATGGCATAACTGAAT
CTTGTGCCACATCTTATTCAAAAGATTTTGGTGGAGGCACTACCAAGATATTTGACAAGCCAAGGAAGCGAAAACGACAGAGGCATGCTG
CAGCCAAGATGCAGTGTAAAAAAGTGAAAAATGATGACTCGTCAAAAGAGATTCCAGGCTCAGAGGGAGAACTAATGCCTCACAGGACGG
CCACAAGCCCCAAGGAGACTGTTGAGGAAGGTGTAGAACACGATCCCGGGATGCCTGCCTCTAAAAAAATGCAGGGTGAACGCGGTGGAG
GAGCTGCACTCAAGGAGAATGTCTGTCAGAATTGTGAAAAATTGGGTGAGCTGCTGTTATGTGAGGCTCAGTGCTGTGGGGCTTTCCACC
TGGAGTGCCTTGGATTGACTGAGATGCCAAGAGGAAAATTTATCTGCAATGAATGTCGCACAGGAATCCATACCTGTTTTGTATGTAAGC
AGAGTGGGGAAGATGTTAAAAGGTGCCTTCTACCCTTGTGTGGAAAGTTTTACCATGAAGAGTGTGTCCAGAAGTACCCACCCACTGTTA
TGCAGAACAAGGGCTTCCGGTGCTCCCTCCACATCTGTATAACCTGTCATGCTGCTAATCCAGCCAATGTTTCTGCATCTAAAGGTCGGT
TGATGCGCTGTGTCCGCTGTCCTGTGGCATACCACGCCAATGACTTTTGCCTGGCTGCTGGGTCAAAGATCCTTGCATCTAATAGTATCA
TCTGCCCTAATCACTTTACCCCTAGGCGGGGCTGCCGAAATCATGAGCATGTTAATGTTAGCTGGTGCTTTGTGTGCTCAGAAGGAGGCA
GCCTTCTGTGCTGTGATTCTTGCCCTGCTGCTTTTCATCGTGAATGCCTGAACATTGATATCCCTGAAGGAAACTGGTATTGCAATGACT
GTAAAGCAGGCAAAAAGCCACACTACAGGGAGATTGTCTGGGTAAAAGTTGGACGATACAGGTGGTGGCCAGCTGAGATCTGCCATCCTC
GAGCTGTTCCTTCCAACATTGATAAGATGAGACATGATGTGGGAGAGTTCCCAGTCCTCTTTTTTGGATCTAATGACTATTTGTGGACTC
ACCAGGCCCGAGTCTTCCCTTACATGGAGGGTGACGTGAGCAGCAAGGATAAGATGGGCAAAGGAGTGGATGGGACATATAAAAAAGCTC
TTCAGGAAGCTGCAGCAAGGTTTGAGGAATTAAAGGCCCAAAAAGAGCTAAGACAGCTGCAGGAAGACCGAAAGAATGACAAGAAGCCAC
CACCTTATAAACATATAAAGGTAAACCGTCCTATTGGCAGGGTACAGATCTTCACTGCAGACTTATCTGAAATACCCCGTTGCAACTGTA
AAGCTACTGATGAGAACCCCTGTGGGATAGACTCTGAATGCATCAACCGCATGCTGCTCTATGAGTGCCACCCCACAGTGTGTCCTGCCG
GAGGGCGCTGTCAAAACCAGTGCTTTTCCAAGCGCCAATATCCAGAGGTTGAAATTTTCCGCACATTACAGCGGGGTTGGGGTCTACGGA
CAAAAACAGATATTAAAAAGGGTGAATTTGTGAATGAGTATGTGGGTGAGCTTATAGATGAAGAAGAATGCAGAGCTCGAATTCGCTATG
CTCAAGAACATGATATCACTAATTTCTATATGCTCACCCTAGACAAAGACCGAATCATTGATGCTGGTCCCAAAGGAAACTATGCTCGGT
TCATGAATCATTGCTGCCAGCCCAACTGTGAAACACAGAAGTGGTCTGTGAATGGAGATACCCGTGTAGGCCTTTTTGCACTAAGTGACA
TTAAAGCAGGCACTGAACTTACCTTCAACTACAACCTAGAATGTCTTGGGAATGGAAAGACTGTTTGCAAATGTGGAGCCCCGAACTGCA
GTGGCTTCTTGGGTGTAAGGCCAAAGAATCAACCCATTGCCACGGAAGAAAAGTCAAAGAAATTCAAGAAGAAGCAACAGGGAAAGCGCA
GGACCCAGGGTGAAATCACAAAGGAGCGAGAAGATGAGTGTTTTAGTTGTGGGGATGCTGGCCAGCTCGTCTCCTGCAAGAAACCAGGCT
GCCCAAAAGTTTACCACGCAGACTGTCTCAATCTGACCAAGCGACCAGCAGGGAAATGGGAATGTCCGTGGCATCAGTGTGACATCTGCG
GGAAGGAAGCAGCCTCCTTCTGTGAGATGTGCCCCAGCTCCTTTTGTAAGCAGCATCGAGAAGGGATGCTTTTCATTTCCAAACTGGATG
GGCGTCTGTCTTGTACTGAGCATGACCCCTGTGGGCCCAATCCTCTGGAACCTGGGGAGATCCGTGAGTATGTGCCTCCCCCAGTACCGC
TGCCTCCAGGGCCAAGCACTCACCTGGCAGAGCAATCAACAGGAATGGCTGCTCAGGCACCCAAAATGTCAGATAAACCTCCTGCTGACA
CCAACCAGATGCTGTCGCTCTCCAAAAAAGCTCTGGCAGGGACTTGTCAGAGGCCATTGCTACCTGAAAGACCTCTTGAGAGAACTGACT
CCAGGCCCCAGCCTTTAGATAAGGTCAGAGACCTCGCTGGGTCAGGGACCAAATCCCAATCCTTGGTTTCCAGCCAGAGGCCACTGGACA
GGCCACCAGCAGTGGCAGGACCAAGACCCCAGCTAAGCGACAAACCCTCTCCAGTGACCAGCCCAAGCTCCTCACCCTCAGTCAGGTCCC
AACCACTGGAAAGACCTCTGGGGACGGCTGACCCAAGGCTGGATAAATCCATAGGTGCTGCCAGCCCAAGGCCCCAGTCACTGGAGAAAA
CCTCAGTTCCCACTGGCCTGAGACTTCCGCCGCCAGACAGACTGCTCATTACTAGCAGTCCCAAACCCCAGACTTCAGACAGGCCTACTG
ACAAACCCCATGCCTCTTTGTCCCAGAGACTCCCACCTCCTGAGAAAGTACTATCAGCTGTGGTCCAGACCCTTGTAGCTAAAGAAAAAG
CACTGAGGCCTGTGGACCAGAATACTCAGTCAAAAAATAGAGCTGCTTTGGTGATGGATCTCATAGACCTAACTCCTCGCCAGAAGGAGC
GGGCAGCTTCACCTCATCAGGTCACACCACAGGCTGATGAGAAGATGCCAGTGTTGGAGTCAAGTTCATGGCCTGCCAGCAAAGGTCTGG
GGCATATGCCGAGAGCTGTTGAGAAAGGCTGTGTGTCAGATCCTCTTCAGACATCTGGGAAAGCAGCAGCCCCTTCAGAGGACCCCTGGC
AAGCTGTTAAATCACTCACCCAGGCCAGACTTCTTTCTCAGCCTCCTGCCAAGGCCTTTTTATATGAGCCAACAACTCAGGCCTCAGGAA
GAGCTTCTGCAGGGGCTGAGCAGACCCCAGGGCCTCTTAGCCAATCCCCGGGCCTGGTGAAGCAGGCGAAGCAGATGGTCGGAGGCCAGC
AACTACCTGCACTTGCCGCCAAGAGTGGGCAATCTTTTAGGTCTCTCGGGAAGGCCCCAGCCTCCCTCCCCACTGAAGAAAAGAAGTTGG
TAACCACAGAGCAAAGTCCCTGGGCCCTGGGAAAAGCCTCATCACGGGCAGGGCTCTGGCCCATAGTGGCTGGACAGACACTGGCACAGT
CTTGCTGGTCTGCTGGGAGCACACAGACATTGGCACAGACTTGCTGGTCTCTTGGAAGAGGGCAAGACCCCAAACCAGAGCAAAATACAC
TTCCAGCTCTTAACCAGGCTCCTTCCAGTCACAAGTGTGCAGAATCAGAACAGAAGTAGTACCAATCAATGTCACATGAACAAACAAGCT
GCCCCCAGGGTACCATTTGGGGAGGGGAAATCTTTTCTTTCTTTCCCCCTTAAAAAAAAACACATCTGCCCCGAACACTTTCCCACTGTT
ATTCTTTCCTCATATCCCAACACTCAGAACTCTTGTGACATTAGCCAGTGGGGGCTTATGGTTGTGTGAACCATGTATGAAAATCCAGTG
GGCCCCAACCAAGGAGACAGACAGACTTGGGTCTCTTTCCCCCAACTTTTCCACATGGTCATCGTGAAATAAAAAGTCCACTCTGGAGTC
AA

>15062_15062_1_CDH23-NSD1_CDH23_chr10_73501678_ENST00000224721_NSD1_chr5_176618885_ENST00000347982_length(amino acids)=4007AA_BP=1618
MGRHVATSCHVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLR
QPLDRETKSEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPEVGATGNTPVGTPIFIVNATDPDLGAGGSVLYSFQPPS
QFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDK
GRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSV
AITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAK
VKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIA
RDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSR
PLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEG
STQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDP
DLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPF
VAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHV
LDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDN
GPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRP
LDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGK
FEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQ
ITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVG
QRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPP
VIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLS
CQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVSNRRPYRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEELPVLR
RRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNRKCIPGSIKLDSEEDMPFEDCTNDPESEHDLLLNGCLKSLAFDSEHSADE
KEKPCAKSRARKSSDNPKRTSVKKGHIQFEAHKDERRGKIPENLGLNFISGDISDTQASNELSRIANSLTGSNTAPGSFLFSSCGKNTAK
KEFETSNGDSLLGLPEGALISKCSREKNKPQRSLVCGSKVKLCYIGAGDEEKRSDSISICTTSDDGSSDLDPIEHSSESDNSVLEIPDAF
DRTENMLSMQKNEKIKYSRFAATNTRVKAKQKPLISNSHTDHLMGCTKSAEPGTETSQVNLSDLKASTLVHKPQSDFTNDALSPKFNLSS
SISSENSLIKGGAANQALLHSKSKQPKFRSIKCKHKENPVMAEPPVINEECSLKCCSSDTKGSPLASISKSGKVDGLKLLNNMHEKTRDS
SDIETAVVKHVLSELKELSYRSLGEDVSDSGTSKPSKPLLFSSASSQNHIPIEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSP
GRGDCSTNSPVGVSKVLVSGGSTHNSEKKGDGTQNSANPSPSGGDSALSGELSASLPGLLSDKRDLPASGKSRSDCVTRRNCGRSKPSSK
LRDAFSAQMVKNTVNRKALKTERKRKLNQLPSVTLDAVLQGDRERGGSLRGGAEDPSKEDPLQIMGHLTSEDGDHFSDVHFDSKVKQSDP
GKISEKGLSFENGKGPELDSVMNSENDELNGVNQVVPKKRWQRLNQRRTKPRKRMNRFKEKENSECAFRVLLPSDPVQEGRDEFPEHRTP
SASILEEPLTEQNHADCLDSAGPRLNVCDKSSASIGDMEKEPGIPSLTPQAELPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKKKQK
KVQEQVHKVSSRCEEESLLARGRSSAQNKQVDENSLISTKEEPPVLEREAPFLEGPLAQSELGGGHAELPQLTLSVPVAPEVSPRPALES
EELLVKTPGNYESKRQRKPTKKLLESNDLDPGFMPKKGDLGLSKKCYEAGHLENGITESCATSYSKDFGGGTTKIFDKPRKRKRQRHAAA
KMQCKKVKNDDSSKEIPGSEGELMPHRTATSPKETVEEGVEHDPGMPASKKMQGERGGGAALKENVCQNCEKLGELLLCEAQCCGAFHLE
CLGLTEMPRGKFICNECRTGIHTCFVCKQSGEDVKRCLLPLCGKFYHEECVQKYPPTVMQNKGFRCSLHICITCHAANPANVSASKGRLM
RCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTPRRGCRNHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCK
AGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMGKGVDGTYKKALQ
EAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGG
RCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFM
NHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIATEEKSKKFKKKQQGKRRT
QGEITKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGR
LSCTEHDPCGPNPLEPGEIREYVPPPVPLPPGPSTHLAEQSTGMAAQAPKMSDKPPADTNQMLSLSKKALAGTCQRPLLPERPLERTDSR
PQPLDKVRDLAGSGTKSQSLVSSQRPLDRPPAVAGPRPQLSDKPSPVTSPSSSPSVRSQPLERPLGTADPRLDKSIGAASPRPQSLEKTS
VPTGLRLPPPDRLLITSSPKPQTSDRPTDKPHASLSQRLPPPEKVLSAVVQTLVAKEKALRPVDQNTQSKNRAALVMDLIDLTPRQKERA
ASPHQVTPQADEKMPVLESSSWPASKGLGHMPRAVEKGCVSDPLQTSGKAAAPSEDPWQAVKSLTQARLLSQPPAKAFLYEPTTQASGRA
SAGAEQTPGPLSQSPGLVKQAKQMVGGQQLPALAAKSGQSFRSLGKAPASLPTEEKKLVTTEQSPWALGKASSRAGLWPIVAGQTLAQSC
WSAGSTQTLAQTCWSLGRGQDPKPEQNTLPALNQAPSSHKCAESEQK

--------------------------------------------------------------
>15062_15062_2_CDH23-NSD1_CDH23_chr10_73501678_ENST00000224721_NSD1_chr5_176618885_ENST00000354179_length(transcript)=16780nt_BP=4865nt
GAGCCATGGGGCGCCATGTTGCCACCAGCTGCCACGTGGCCTGGCTTTTGGTGCTGATCTCTGGATGCTGGGGCCAGGTGAACCGGCTGC
CCTTCTTCACCAACCACTTCTTTGATACATACCTGCTGATCAGCGAGGACACGCCTGTGGGTTCTTCTGTGACCCAGTTGCTGGCCCAAG
ACATGGACAATGACCCCCTGGTGTTTGGCGTGTCTGGGGAGGAGGCCTCTCGCTTCTTTGCAGTGGAGCCTGACACTGGCGTGGTGTGGC
TCCGGCAGCCACTGGACAGAGAGACCAAGTCAGAGTTCACCGTGGAGTTCTCTGTCAGCGACCACCAGGGGGTGATCACACGGAAGGTGA
ACATCCAGGTTGGGGATGTGAATGACAACGCGCCCACATTTCACAATCAGCCCTACAGCGTCCGCATCCCTGAGGTAGGAGCCACTGGGA
ATACACCAGTGGGGACGCCCATCTTCATCGTGAATGCCACAGACCCCGACTTGGGGGCAGGGGGCAGCGTCCTCTACTCCTTCCAGCCCC
CCTCCCAATTCTTCGCCATTGACAGCGCCCGCGGTATCGTCACAGTGATCCGGGAGCTGGACTACGAGACCACACAGGCCTACCAGCTCA
CGGTCAACGCCACAGATCAAGACAAGACCAGGCCTCTGTCCACCCTGGCCAACTTGGCCATCATCATCACAGATGTCCAGGACATGGACC
CCATCTTCATCAACCTGCCTTACAGCACCAACATCTACGAGCATTCTCCTCCGGGCACGACGGTGCGCATCATCACCGCCATAGACCAGG
ATAAAGGACGTCCCCGGGGCATTGGCTACACCATCGTTTCAGGGAATACCAACAGCATCTTTGCCCTGGACTACATCAGCGGAGTGCTGA
CCTTGAATGGCCTGCTGGACCGGGAGAACCCCCTGTACAGCCATGGCTTCATCCTGACTGTGAAGGGCACGGAGCTGAACGATGACCGCA
CCCCATCTGACGCTACAGTCACCACGACCTTCAATATCCTGGTTATTGACATCAATGACAATGCCCCGGAGTTCAACAGCTCCGAGTACA
GCGTGGCCATCACTGAGCTGGCACAGGTCGGCTTTGCCCTTCCACTCTTCATCCAGGTGGTGGACAAGGATGAGAATTTGGGCCTGAACA
GCATGTTTGAGGTGTACTTGGTGGGGAACAACTCCCACCACTTCATCATCTCCCCGACCTCCGTCCAGGGGAAGGCGGACATTCGTATTC
GGGTGGCCATCCCACTGGACTACGAGACCGTGGACCGCTACGACTTTGATCTCTTTGCCAATGAGAGTGTGCCTGACCATGTGGGCTATG
CCAAGGTGAAGATCACTCTCATCAATGAAAATGACAACCGGCCCATCTTCAGCCAGCCACTGTACAACATCAGCCTGTACGAGAACGTCA
CCGTGGGGACCTCTGTGCTGACAGTCCTGGCAACTGACAATGATGCAGGCACCTTTGGGGAAGTCAGCTACTTCTTCAGTGATGACCCTG
ACAGGTTCTCGCTGGACAAGGACACGGGACTCATCATGCTGATTGCCAGGCTGGACTATGAGCTCATCCAGCGCTTCACCCTGACGATCA
TTGCCCGGGACGGGGGCGGCGAGGAGACCACAGGCCGGGTCAGGATCAATGTGTTGGATGTCAACGACAACGTGCCCACCTTCCAGAAGG
ATGCCTACGTGGGTGCTCTGCGGGAGAACGAGCCTTCTGTCACACAGCTGGTGCGGCTCCGGGCAACAGATGAAGACTCCCCTCCCAACA
ACCAGATCACCTACAGCATTGTCAGTGCATCTGCCTTTGGCAGCTACTTCGACATCAGCCTGTACGAGGGCTATGGAGTGATCAGCGTCA
GTCGCCCCCTGGATTATGAACAGATATCCAATGGGCTGATTTATCTGACGGTCATGGCCATGGATGCTGGCAACCCCCCTCTCAACAGCA
CCGTCCCTGTCACCATCGAGGTGTTTGATGAGAATGACAACCCTCCCACCTTCAGCAAGCCCGCCTACTTCGTCTCCGTGGTGGAGAACA
TCATGGCAGGAGCCACGGTGCTGTTCCTGAATGCCACAGACCTGGACCGCTCCCGGGAGTACGGCCAGGAGTCCATCATCTACTCCTTGG
AAGGCTCCACCCAGTTTCGGATCAATGCCCGCTCAGGGGAAATCACCACCACGTCTCTGCTTGACCGAGAGACCAAGTCTGAATACATCC
TCATCGTTCGCGCAGTGGACGGGGGTGTGGGCCACAACCAGAAAACTGGCATCGCCACCGTAAACATCACCCTCCTGGACATCAATGACA
ACCACCCCACGTGGAAGGACGCACCCTACTACATCAACCTGGTGGAGATGACCCCTCCAGACTCTGATGTGACCACGGTGGTGGCTGTTG
ACCCAGACCTGGGGGAGAATGGCACCCTGGTGTACAGCATCCAGCCACCCAACAAGTTCTACAGCCTCAACAGCACCACGGGCAAGATCC
GCACCACCCACGCCATGCTGGACCGGGAGAACCCCGACCCCCATGAGGCCGAGCTGATGCGCAAAATCGTCGTCTCTGTTACTGACTGTG
GCAGGCCCCCTCTGAAAGCCACCAGCAGTGCCACAGTGTTTGTGAACCTCTTGGATCTCAATGACAATGACCCCACCTTTCAGAACCTGC
CTTTTGTGGCCGAGGTGCTTGAAGGCATCCCGGCGGGGGTCTCCATCTACCAAGTGGTGGCCATCGACCTCGATGAGGGCCTGAACGGCC
TGGTGTCCTACCGCATGCCGGTGGGCATGCCCCGCATGGACTTCCTCATCAACAGCAGCAGCGGCGTGGTGGTCACCACCACCGAGCTGG
ACCGCGAGCGCATCGCGGAGTACCAGCTGCGGGTGGTGGCCAGTGATGCAGGCACGCCCACCAAGAGCTCCACCAGCACGCTCACCATCC
ATGTGCTGGATGTGAACGACGAGACGCCCACCTTCTTCCCGGCCGTGTACAATGTGTCTGTGTCCGAGGACGTGCCACGCGAGTTCCGGG
TGGTCTGGCTGAACTGCACGGACAACGACGTGGGCCTCAATGCAGAGCTCAGCTACTTCATCACAGGTGGCAACGTGGATGGGAAGTTCA
GCGTGGGTTACCGCGATGCCGTTGTGAGAACCGTGGTGGGCCTGGACCGGGAGACCACAGCCGCCTACATGCTCATCCTGGAGGCCATCG
ACAACGGCCCTGTAGGGAAGCGACACACGGGCACAGCCACCGTGTTCGTCACTGTCCTGGATGTGAATGACAACCGGCCCATCTTTCTGC
AGAGCAGCTATGAGGCCAGCGTCCCTGAGGACATCCCTGAAGGCCACAGCATCTTGCAGCTGAAAGCCACGGACGCAGATGAGGGCGAGT
TTGGGCGTGTGTGGTACCGCATCCTCCATGGTAACCATGGCAACAACTTCCGGATCCATGTCAGCAATGGGCTCCTGATGCGAGGGCCCC
GGCCCCTGGACCGGGAGCGGAACTCATCCCACGTGCTGATAGTGGAGGCCTACAACCACGACCTGGGCCCCATGCGGAGCTCCGTCAGGG
TGATTGTGTACGTGGAGGACATCAACGATGAGGCCCCCGTGTTCACACAGCAGCAGTACAGCCGTCTGGGGCTTCGAGAGACCGCAGGCA
TTGGAACGTCAGTCATCGTGGTCCAAGCCACAGACCGAGACTCTGGGGATGGTGGCCTGGTGAACTACCGCATCCTGTCGGGCGCAGAGG
GGAAGTTTGAGATTGACGAGAGCACAGGGCTTATCATCACCGTGAATTACCTGGACTACGAGACCAAGACCAGCTACATGATGAATGTGT
CGGCCACTGACCAGGCCCCGCCCTTCAACCAGGGCTTCTGCAGCGTCTACATCACTCTGCTCAACGAGCTGGACGAGGCCGTGCAGTTCT
CCAATGCCTCATACGAGGCTGCCATCCTGGAGAATCTGGCACTGGGTACTGAGATTGTGCGGGTCCAGGCCTACTCCATCGACAACCTCA
ACCAAATCACGTACCGCTTCAACGCCTACACCAGCACCCAGGCCAAAGCCCTCTTCAAGATAGACGCCATCACGGGTGTGATCACAGTCC
AGGGCCTGGTGGACCGTGAGAAGGGCGACTTCTATACCTTGACAGTGGTGGCAGATGACGGCGGCCCCAAGGTGGACTCCACCGTGAAGG
TCTACATCACTGTGCTGGACGAGAATGACAACAGCCCCCGGTTTGACTTCACCTCCGACTCGGCGGTCAGCATACCCGAGGACTGCCCTG
TGGGCCAGCGAGTGGCTACTGTCAAGGCCTGGGACCCTGATGCTGGCAGCAATGGGCAGGTGGTCTTCTCCCTGGCCTCTGGCAACATCG
CGGGGGCCTTTGAGATCGTCACCACCAATGACTCCATTGGCGAAGTGTTTGTGGCCAGGCCCCTGGACAGAGAAGAGCTGGATCACTACA
TCCTCCAGGTTGTGGCTTCTGACCGAGGCACCCCTCCACGGAAGAAGGACCACATCCTGCAGGTGACCATCCTGGACATCAATGACAACC
CTCCAGTCATCGAGAGCCCCTTTGGATACAATGTCAGTGTGAATGAGAACGTGGGTGGAGGTACTGCTGTGGTCCAGGTGAGAGCCACTG
ACCGTGACATCGGGATCAACAGTGTTCTGTCCTACTACATCACCGAGGGCAACAAGGACATGGCCTTCCGCATGGACCGCATCAGCGGTG
AGATCGCCACACGGCCTGCCCCGCCTGACCGCGAGCGCCAGAGCTTCTACCACCTGGTGGCCACTGTGGAGGACGAGGGCACCCCAACCC
TGTCGTGTCAACCTAAGAAAAAGTCTACGCCACTGAAGTATGAAGTTGGAGATCTCATCTGGGCAAAATTCAAGAGACGCCCATGGTGGC
CCTGCAGGATTTGTTCTGATCCGTTGATTAACACACATTCAAAAATGAAAGTTTCCAACCGGAGGCCCTATCGGCAGTACTACGTGGAGG
CTTTTGGAGATCCTTCTGAGAGAGCCTGGGTGGCTGGAAAAGCAATCGTCATGTTTGAAGGCAGACATCAATTCGAAGAGCTACCTGTCC
TTAGGAGAAGAGGGAAACAGAAAGAAAAAGGATATAGGCATAAGGTTCCTCAGAAAATTTTGAGTAAATGGGAAGCCAGTGTTGGACTTG
CAGAACAGTATGATGTTCCCAAGGGGTCAAAGAACCGAAAATGTATTCCTGGTTCAATCAAGTTGGACAGTGAAGAAGATATGCCATTTG
AAGACTGCACAAATGATCCTGAGTCAGAACATGACCTGTTGCTTAATGGCTGTTTGAAATCACTGGCTTTTGATTCTGAACATTCTGCAG
ATGAGAAGGAAAAGCCTTGCGCTAAATCTCGAGCCAGAAAGAGCTCTGATAATCCAAAAAGGACTAGTGTGAAAAAGGGCCACATACAAT
TTGAAGCACATAAAGATGAACGGAGGGGAAAGATTCCAGAGAACCTTGGCCTAAACTTTATCTCTGGGGATATATCTGATACGCAGGCCT
CTAATGAACTTTCCAGGATAGCAAATAGCCTCACAGGGTCCAACACTGCCCCAGGAAGTTTTCTGTTTTCTTCCTGTGGAAAAAACACTG
CAAAGAAAGAATTTGAGACTTCAAATGGTGACTCTTTATTGGGCTTGCCTGAGGGTGCTTTGATCTCAAAGTGTTCTCGAGAGAAGAATA
AACCCCAACGAAGCCTGGTGTGTGGTTCAAAAGTGAAGCTCTGCTATATTGGAGCAGGTGATGAGGAAAAGCGAAGTGATTCCATTAGTA
TCTGTACCACTTCTGATGATGGAAGCAGTGACCTGGATCCCATAGAACACAGCTCAGAGTCTGATAACAGTGTCCTTGAAATTCCAGATG
CTTTCGATAGAACAGAGAACATGTTATCTATGCAGAAAAATGAAAAGATAAAGTATTCTAGGTTTGCTGCCACAAACACTAGGGTAAAAG
CAAAACAGAAGCCTCTCATTAGTAACTCACATACAGACCACTTAATGGGTTGTACTAAGAGTGCAGAGCCTGGAACCGAGACGTCTCAGG
TTAATCTCTCTGATCTGAAGGCATCTACTCTTGTTCACAAACCCCAGTCAGATTTTACAAATGATGCTCTCTCTCCAAAATTCAACCTGT
CATCAAGCATATCCAGTGAGAACTCGTTAATAAAGGGTGGGGCAGCAAATCAAGCTCTATTACATTCGAAAAGCAAACAGCCCAAGTTCC
GAAGTATAAAGTGCAAACACAAAGAAAATCCAGTTATGGCAGAACCCCCAGTTATAAATGAGGAGTGCAGTTTGAAATGCTGCTCTTCTG
ATACCAAAGGCTCTCCTTTGGCCAGCATTTCTAAAAGTGGGAAAGTGGATGGTCTAAAACTACTGAACAATATGCATGAGAAAACCAGGG
ATTCAAGTGACATAGAAACAGCAGTGGTGAAACATGTTTTATCCGAGTTGAAGGAACTCTCTTACAGATCCTTAGGTGAGGATGTCAGTG
ACTCTGGAACATCAAAGCCATCAAAACCATTACTTTTCTCTTCTGCTTCTAGTCAGAATCACATACCTATTGAACCAGACTACAAATTCA
GTACATTGCTAATGATGTTGAAAGATATGCATGATAGTAAGACGAAGGAGCAGCGGTTGATGACTGCTCAAAACCTGGTCTCTTACCGGA
GTCCTGGTCGTGGGGACTGTTCTACTAATAGTCCTGTAGGAGTCTCTAAGGTTTTGGTTTCAGGAGGCTCCACACACAATTCAGAGAAAA
AGGGAGATGGCACTCAGAACTCCGCCAATCCTAGCCCTAGTGGGGGTGACTCTGCATTATCTGGCGAGTTGTCTGCTTCCCTACCTGGCT
TACTGTCCGACAAGAGAGACCTCCCTGCTTCTGGTAAAAGTCGTTCAGACTGTGTTACTAGGCGCAACTGTGGACGATCAAAGCCTTCAT
CCAAATTGCGAGATGCTTTTTCAGCCCAAATGGTAAAGAACACAGTGAACCGTAAAGCCTTAAAGACCGAGCGCAAAAGAAAACTGAATC
AGCTTCCAAGTGTGACTCTTGATGCTGTACTGCAGGGAGACCGAGAACGTGGAGGTTCATTGAGAGGTGGGGCAGAAGATCCTAGTAAAG
AGGATCCCCTTCAGATAATGGGCCACTTAACAAGTGAAGATGGTGACCATTTTTCTGATGTGCATTTCGATAGCAAGGTTAAGCAATCTG
ATCCTGGTAAAATTTCTGAAAAAGGACTCTCTTTTGAAAACGGAAAAGGCCCAGAGCTGGACTCTGTAATGAACAGTGAGAATGATGAAC
TCAATGGTGTAAATCAAGTGGTGCCTAAAAAGCGGTGGCAGCGTTTAAACCAAAGGCGCACTAAACCTCGTAAGCGCATGAACAGATTTA
AAGAGAAAGAAAACTCTGAGTGTGCCTTTAGGGTCTTACTTCCTAGTGACCCTGTGCAGGAGGGGCGGGATGAGTTTCCAGAGCATAGAA
CTCCTTCAGCAAGCATACTTGAGGAACCACTGACAGAGCAAAATCATGCTGACTGCTTAGATTCAGCTGGGCCACGGTTAAATGTTTGTG
ATAAATCCAGTGCCAGCATTGGTGACATGGAAAAGGAGCCAGGAATTCCCAGTTTGACACCACAGGCTGAGCTCCCTGAACCAGCTGTGC
GGTCAGAGAAGAAACGCCTTAGGAAGCCAAGCAAGTGGCTTTTGGAATATACAGAAGAATATGATCAGATATTTGCTCCTAAGAAAAAAC
AAAAGAAGGTACAGGAGCAGGTGCACAAGGTAAGTTCCCGCTGTGAAGAGGAAAGCCTTCTAGCCCGAGGTCGATCTAGTGCTCAGAACA
AGCAGGTGGACGAGAATTCTTTGATTTCAACCAAAGAAGAGCCTCCAGTTCTTGAAAGGGAGGCTCCGTTTTTGGAGGGCCCCTTGGCTC
AGTCAGAACTTGGAGGTGGACATGCTGAGTTGCCGCAGCTGACCTTGTCTGTGCCTGTGGCTCCGGAAGTCTCTCCACGGCCTGCCCTTG
AGTCTGAGGAATTGCTAGTTAAAACGCCAGGAAATTATGAAAGTAAACGTCAAAGAAAACCAACTAAGAAACTTCTTGAATCCAATGATT
TAGACCCTGGATTTATGCCCAAGAAGGGGGACCTTGGCCTTTCTAAAAAGTGCTATGAAGCTGGTCACCTGGAGAATGGCATAACTGAAT
CTTGTGCCACATCTTATTCAAAAGATTTTGGTGGAGGCACTACCAAGATATTTGACAAGCCAAGGAAGCGAAAACGACAGAGGCATGCTG
CAGCCAAGATGCAGTGTAAAAAAGTGAAAAATGATGACTCGTCAAAAGAGATTCCAGGCTCAGAGGGAGAACTAATGCCTCACAGGACGG
CCACAAGCCCCAAGGAGACTGTTGAGGAAGGTGTAGAACACGATCCCGGGATGCCTGCCTCTAAAAAAATGCAGGGTGAACGCGGTGGAG
GAGCTGCACTCAAGGAGAATGTCTGTCAGAATTGTGAAAAATTGGGTGAGCTGCTGTTATGTGAGGCTCAGTGCTGTGGGGCTTTCCACC
TGGAGTGCCTTGGATTGACTGAGATGCCAAGAGGAAAATTTATCTGCAATGAATGTCGCACAGGAATCCATACCTGTTTTGTATGTAAGC
AGAGTGGGGAAGATGTTAAAAGGTGCCTTCTACCCTTGTGTGGAAAGTTTTACCATGAAGAGTGTGTCCAGAAGTACCCACCCACTGTTA
TGCAGAACAAGGGCTTCCGGTGCTCCCTCCACATCTGTATAACCTGTCATGCTGCTAATCCAGCCAATGTTTCTGCATCTAAAGGTCGGT
TGATGCGCTGTGTCCGCTGTCCTGTGGCATACCACGCCAATGACTTTTGCCTGGCTGCTGGGTCAAAGATCCTTGCATCTAATAGTATCA
TCTGCCCTAATCACTTTACCCCTAGGCGGGGCTGCCGAAATCATGAGCATGTTAATGTTAGCTGGTGCTTTGTGTGCTCAGAAGGAGGCA
GCCTTCTGTGCTGTGATTCTTGCCCTGCTGCTTTTCATCGTGAATGCCTGAACATTGATATCCCTGAAGGAAACTGGTATTGCAATGACT
GTAAAGCAGGCAAAAAGCCACACTACAGGGAGATTGTCTGGGTAAAAGTTGGACGATACAGGTGGTGGCCAGCTGAGATCTGCCATCCTC
GAGCTGTTCCTTCCAACATTGATAAGATGAGACATGATGTGGGAGAGTTCCCAGTCCTCTTTTTTGGATCTAATGACTATTTGTGGACTC
ACCAGGCCCGAGTCTTCCCTTACATGGAGGGTGACGTGAGCAGCAAGGATAAGATGGGCAAAGGAGTGGATGGGACATATAAAAAAGCTC
TTCAGGAAGCTGCAGCAAGGTTTGAGGAATTAAAGGCCCAAAAAGAGCTAAGACAGCTGCAGGAAGACCGAAAGAATGACAAGAAGCCAC
CACCTTATAAACATATAAAGGTAAACCGTCCTATTGGCAGGGTACAGATCTTCACTGCAGACTTATCTGAAATACCCCGTTGCAACTGTA
AAGCTACTGATGAGAACCCCTGTGGGATAGACTCTGAATGCATCAACCGCATGCTGCTCTATGAGTGCCACCCCACAGTGTGTCCTGCCG
GAGGGCGCTGTCAAAACCAGTGCTTTTCCAAGCGCCAATATCCAGAGGTTGAAATTTTCCGCACATTACAGCGGGGTTGGGGTCTACGGA
CAAAAACAGATATTAAAAAGGGTGAATTTGTGAATGAGTATGTGGGTGAGCTTATAGATGAAGAAGAATGCAGAGCTCGAATTCGCTATG
CTCAAGAACATGATATCACTAATTTCTATATGCTCACCCTAGACAAAGACCGAATCATTGATGCTGGTCCCAAAGGAAACTATGCTCGGT
TCATGAATCATTGCTGCCAGCCCAACTGTGAAACACAGAAGTGGTCTGTGAATGGAGATACCCGTGTAGGCCTTTTTGCACTAAGTGACA
TTAAAGCAGGCACTGAACTTACCTTCAACTACAACCTAGAATGTCTTGGGAATGGAAAGACTGTTTGCAAATGTGGAGCCCCGAACTGCA
GTGGCTTCTTGGGTGTAAGGCCAAAGAATCAACCCATTGCCACGGAAGAAAAGTCAAAGAAATTCAAGAAGAAGCAACAGGGAAAGCGCA
GGACCCAGGGTGAAATCACAAAGGAGCGAGAAGATGAGTGTTTTAGTTGTGGGGATGCTGGCCAGCTCGTCTCCTGCAAGAAACCAGGCT
GCCCAAAAGTTTACCACGCAGACTGTCTCAATCTGACCAAGCGACCAGCAGGGAAATGGGAATGTCCGTGGCATCAGTGTGACATCTGCG
GGAAGGAAGCAGCCTCCTTCTGTGAGATGTGCCCCAGCTCCTTTTGTAAGCAGCATCGAGAAGGGATGCTTTTCATTTCCAAACTGGATG
GGCGTCTGTCTTGTACTGAGCATGACCCCTGTGGGCCCAATCCTCTGGAACCTGGGGAGATCCGTGAGTATGTGCCTCCCCCAGTACCGC
TGCCTCCAGGGCCAAGCACTCACCTGGCAGAGCAATCAACAGGAATGGCTGCTCAGGCACCCAAAATGTCAGATAAACCTCCTGCTGACA
CCAACCAGATGCTGTCGCTCTCCAAAAAAGCTCTGGCAGGGACTTGTCAGAGGCCATTGCTACCTGAAAGACCTCTTGAGAGAACTGACT
CCAGGCCCCAGCCTTTAGATAAGGTCAGAGACCTCGCTGGGTCAGGGACCAAATCCCAATCCTTGGTTTCCAGCCAGAGGCCACTGGACA
GGCCACCAGCAGTGGCAGGACCAAGACCCCAGCTAAGCGACAAACCCTCTCCAGTGACCAGCCCAAGCTCCTCACCCTCAGTCAGGTCCC
AACCACTGGAAAGACCTCTGGGGACGGCTGACCCAAGGCTGGATAAATCCATAGGTGCTGCCAGCCCAAGGCCCCAGTCACTGGAGAAAA
CCTCAGTTCCCACTGGCCTGAGACTTCCGCCGCCAGACAGACTGCTCATTACTAGCAGTCCCAAACCCCAGACTTCAGACAGGCCTACTG
ACAAACCCCATGCCTCTTTGTCCCAGAGACTCCCACCTCCTGAGAAAGTACTATCAGCTGTGGTCCAGACCCTTGTAGCTAAAGAAAAAG
CACTGAGGCCTGTGGACCAGAATACTCAGTCAAAAAATAGAGCTGCTTTGGTGATGGATCTCATAGACCTAACTCCTCGCCAGAAGGAGC
GGGCAGCTTCACCTCATCAGGTCACACCACAGGCTGATGAGAAGATGCCAGTGTTGGAGTCAAGTTCATGGCCTGCCAGCAAAGGTCTGG
GGCATATGCCGAGAGCTGTTGAGAAAGGCTGTGTGTCAGATCCTCTTCAGACATCTGGGAAAGCAGCAGCCCCTTCAGAGGACCCCTGGC
AAGCTGTTAAATCACTCACCCAGGCCAGACTTCTTTCTCAGCCTCCTGCCAAGGCCTTTTTATATGAGCCAACAACTCAGGCCTCAGGAA
GAGCTTCTGCAGGGGCTGAGCAGACCCCAGGGCCTCTTAGCCAATCCCCGGGCCTGGTGAAGCAGGCGAAGCAGATGGTCGGAGGCCAGC
AACTACCTGCACTTGCCGCCAAGAGTGGGCAATCTTTTAGGTCTCTCGGGAAGGCCCCAGCCTCCCTCCCCACTGAAGAAAAGAAGTTGG
TAACCACAGAGCAAAGTCCCTGGGCCCTGGGAAAAGCCTCATCACGGGCAGGGCTCTGGCCCATAGTGGCTGGACAGACACTGGCACAGT
CTTGCTGGTCTGCTGGGAGCACACAGACATTGGCACAGACTTGCTGGTCTCTTGGAAGAGGGCAAGACCCCAAACCAGAGCAAAATACAC
TTCCAGCTCTTAACCAGGCTCCTTCCAGTCACAAGTGTGCAGAATCAGAACAGAAGTAGTACCAATCAATGTCACATGAACAAACAAGCT
GCCCCCAGGGTACCATTTGGGGAGGGGAAATCTTTTCTTTCTTTCCCCCTTAAAAAAAAACACATCTGCCCCGAACACTTTCCCACTGTT
ATTCTTTCCTCATATCCCAACACTCAGAACTCTTGTGACATTAGCCAGTGGGGGCTTATGGTTGTGTGAACCATGTATGAAAATCCAGTG
GGCCCCAACCAAGGAGACAGACAGACTTGGGTCTCTTTCCCCCAACTTTTCCACATGGTCATCGTGAAATAAAAAGTCCACTCTGGAGTC
AAGTATGGAATTCAATTCCGCTGGTCAGGTTGGAAGGTATAGGGGCTCTCAAAGCGATTTCCCCAACCAGACAGAGCCCCATTGAGGGCA
CCTAGGAACCCTTGGGAGGAAATGGTGTTCTTTCAAATCAGTGGCGATTTCCTGAGCATTCACGTGTTCTAGGCCGGGTGCTAGTCACTG
ATGAGAGATACAGGCCTCATCCCTGTGAGCCTGGATTCCAAGGCTTTCAGGAACCTTTGACCAGGAAGTAACAGGAAGTTCTGAGGGGCC
CTGGGGCTTTAGACTCATTTTGAAATGTCCTTTGTGGCACCAGAAGTGGTTGTGTTGAGGAAGTGTCTCTTGGCTGCGGTGTGCATGGGT
GCGTGTGCATGCGCGCACACTCACAGAGGTCTCCTCTATAGATGCAAGGGTGCTGCATTGAGGCCAGCAAGGCTGTTGGCTGTGGGGTCG
CCGCTGCTGCTTTTGTCTGGGCTGTGCAGAGTCTCAAGATCAGTCCTTGGAGGAGCAGGTGGTCAGGGGCAGTCGGGCTCTGTGCGAATG
TAGATTTCCAGCAGTGGAAGAAGGCATTTGGCAAGCTTCTCTTTCTTTGCTTTTGTTTCTACCTATTTTTCTCTTTGTACATGAATCCAC
CCCATCCCTATTTCCCTAAAACACTCAGGTGCTTTCAGATTTCAGAGCCTCGGGCAGTGGACATAGGGAATCTCTGGCAAGCTCTGAGCT
AGACACACCAGCTTCAGGAAGAGTACCAGATCCTGATGGGAAATTTCTTTTCCCCATTCCTTTTCCCTCCTGAGTGGAGGGAGTCCTCTT
CTTCGCCTCCCTGAGAATTGCTGTGCTCTGTATTGAGAGCACCTGCCTGCTGACTTAGCTCAAAGGCAAGCCAGAACCCTTCCCTGAAGA
CTGGCAAGAGGTGGTGTTTAGAGCAACGTCCAGGCTAAGAGATGACTCCTATTAACTGCTGATTATCTGTTACTGCTGCCCTGAGCTGGG
GCCCAAGGGCTGGGAAATCTGTTGGTGCTACCCTGCCCTACCATTCACCCAGCTCACAGACTGCCAACAGGAAGTGCTGTTTGGCTAGTT
TCCTCCCACTTGTCTACCCCTCCTTTGTCCTTAGACCAACATGTTTACCTCTCTGCTTTGCCAACTTAGCCAGCAGGCCATCCCCGGCCC
TAACGTCTCCTGGCCATTATCTCTTAGTTATGGCTTTCACGCTCTCAATAGGATTCTGTATTTGGTCCCAATTTCCTCAAGTTCTTATTG
AGGTTACTCCCATCAATTCCACGGAGGGAACAGTAGTTATTATAGAAGCATTTGCGCTTTATCTAAAGATTAAAAATAGAATCTGCTTTT
ATTTCCCAAAGTCTGTCTCTGAGGTTGAGACACTTGAACTCAGGCAGAGGGACGAGGCTGGGCAGGGCTGTCCTGAGTTTAGGGGCCTAT
CCCTGCATTTCACTGAGACCTCGGAATCTCCTCTGTGAATTCCACCTGCCTAGTTCTCCCCTTTCATCCTCTCTCTCTTCCCACATCATC
AAAGAGGAAAAGCTCTTTGTTCAAAAGGAAGAGAAAACGTAAAGCATCTTATTTTCTTTTAAAAGAATTTTAAACCATGAAAAAGATATT
TTTAAAGAAATTCACCGAGAACATTAAAGTTCATTATATTAAGTATTTATCATGTGTGAGAATAATAAATATATAACTGCAGCTAGTAGG
TCCCTTTCCCTAATCTTTTAGGTCATATGAGTAGGGTTTGCTTGGTGCCAGTCCTGTGCCCTTTTCTCTCCAGTCATCTGTAGTTGTGAT
CAGAAAAAGGTATCTGCACTGCACTGTCAGAGTCTCCTTTCACTATGTTGTGTGTTAAATTACCGTAGCTCTTTGTTTCATGAAATAAAC
TGTGAATTTGGGGGGGGCGGGGGGAGGGCGTGCAGGCCATGTAAAAATTTTCCGTGGAGAAGTTTGATTCTAAAGTAGCTTCTCTAAAGT
AGGCTTTGGTAGGTAATCAACTTGACAGCAGTCTAGATGTCTCACAGGACAGGAGGGAGTGAGGGAAAGGGGCCATGATTGGCTGCTTTG
TGGTTTTATTTTGGTTCTTTCCATTCTCCGCCATTCATTGGAGGCTTCGTTCCAGACCTGCCTGGGAAAACAGCTTCTGAGCCATTTTGG
GGAGCAGTTCTTCATCTGAATGGATGGACATCTGGGCTTCCTTCAAGGGCCATTGAATGGGAACTAGAAAACCACTGGAAACTAGAAATT
TGAGCTATTGGGCCCACCAGTAGCAGCATGTGATACTAGATGGTTAAAATCATGAAAGCAGTCACTATCCAATTAGAAGCAGAGTCACAA
CAACTGTTGGGAAATGTGACTCTTGGAGGAAGGTGGGGAGGGAGTGGCCTTGCCAGCCCTGTGGGACGTCCCCTGAAGTTTGTAATAAGA
CCCCTTTTCCAAAGGGATGTGAATTGGAGTGAAAAGGAAATCTTTCATCTTAGAAAACTTCTGGTCCTTAACGCAGGGTGGTATTTGGGT
ATGTGCTTGGAAATTGAGATCTCAAGAGTGTTTGCCTTGGAGCCAGCTCCCCAGGAGGCCTTTTCCAGGGACAAGGCAAAAGTTGAAATT
CTCCATGGGTAGCTAGAAAGCCAATACATCTAGCCCTGCTAAGTCAGAAAAAGATTATGAAAAATGTTGAAATTTACATTCAAAGCCTCA
TTTGCTTATCTTGCTGGAGCCAACCCAGTCTAATAGCAAAATAGCTGTCATTGATACAGAAACATCCTCATTTTTAAATGTCTGCTTTAC
CCTGTTACTGAGTTTGAGATGACTTAAATCACTGTGTTGACCCTCTTCTGAACCAAATCTTTAGCATTGATGAAAATAGTTATTTTATTC
TTTACATCCTTCACCCCACACTATGGTCAGGGCATGAAACACCCTGTTGATCCCTTCCCAGGCTCGGCACTGTCTGCTCACTGGAGCCGG
ACTCCCAGGTTGTAATTCTAATGTTGCCTCATGAGAACAGAATGGCAGAAAGTTTAGTCCTGACAGATTCCCCCATAGGGAGTAATGAGG
ACAGCATGAAACTTGGATAGGTTTTACCCTTAGTCCCTATAAGGTGGATTTTACTAAGGTTTTTTAAATGATACTGTCATCCTCTTGGGG
TTTATCAGCCAGGTTAGAGGAGCCCAGTGTCCTAACCTCTCTCAGATCATGGCAGAGAAGGAGCTGCCTCCAGCCCCTTTCTTGCTGAGT
TTCATTTGAGCAGTTCCATGTGTAGACATTCCAAGTCACTGCTTGGTAGTTGCTGTGGGAGCCTGTCATTGGCTATGGCCAGTTAGTTCT
CAGCTGAGCTTCCTAGGGCCAGTGCAACAGGGCCAGAGGCTGCTATAGTGTAAATTGAAATAAGAATAGATCATTGTTTTGTACACACAC
ACAATAAAATGTAATGATGGTGCTAATTTCACGGTATAAATAAGCACTGCCAAGGGTTGAGGGACTGGCAGCTCAAGAAACCCGGGTTCC
TGTTTGGGAGGAGATTTTATGTAGAAAAGTTTGAGGCTTTGTTAAAAGTGGGGAGAAGGAAGATCCTCAGTGAAGCCTGCACCCAACCCT
GGAGTGGCCCAGTGCAATCCAGAGGTGGAAGAGATCCTATATCCAGGTGAAGGTGGCCATTGAGTTTCTCAGGGCTGGGGCCACCTTGTC
CATAGCCTCCGTCCACGCTGCCTGGAGCAGGTTGTTAGAGAGCTCTGGTTGTTGGGTCTTCCTCAGCTCCCTTCTGCCCCTCTCTACCTC
TTCCACTCATGGAAGCCCCTCTACTGCTTATGAAGATTAAGGGTAGTATTTTCTAAGGAAGTGGAAAGAATTAAACTAGAAATCCACAAC
CTCGGAAGAAGTGTTTCGAGTTTAACATGCGCTGTTTCTGCTTATGTGGTTCCTTCTCTAGAGCTGCTTTCCCATGGCTTTCAAAACATC
AGGTTATTGTGGGGCTTCAGGTGTAAGGTCCTGGAAGTTCAGCAAAGTTTCGTGGACAAGACATGGGCACAGAGAGTAGAAGCAGAAATA
AATGGTTCTATGTTTTCAACTTCCAGGGTTGGGGCAGGCCAGAGCAAGGCGGTCTCATCGAGGTGGGTGCTACCTGTGTGTGTGTAGATG
AGTGTGCTGAAGGTGGGGAGGGCAGCACACAGCAGCTCATGGCAGAGCCGCCTCCTAGGTCTTGGCAAAGAGGCAAGCTGACGATAGACA
TCTACCTATATTGTTAAGAAAGGGGTCGGGGGGATCAGCCAAGGTCCATCATTGCTTTTTTGCCGCGCCCCCCCCCCCCCGCCCCCATAG
ATTGTCAGCTGTAAGTGAAACTCCTAGTGAAAAAGAGGGGAGCCCTGTGTTAGGAGTCCCCATAAACATGTACTGTAATTCTTTGTATAT
AGAAAAAAAATTTACTGTAAAGTAAAGTTTAACTTTACTC

>15062_15062_2_CDH23-NSD1_CDH23_chr10_73501678_ENST00000224721_NSD1_chr5_176618885_ENST00000354179_length(amino acids)=4007AA_BP=1618
MGRHVATSCHVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLR
QPLDRETKSEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPEVGATGNTPVGTPIFIVNATDPDLGAGGSVLYSFQPPS
QFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDK
GRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSV
AITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAK
VKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIA
RDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSR
PLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEG
STQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDP
DLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPF
VAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHV
LDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDN
GPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRP
LDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGK
FEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQ
ITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVG
QRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPP
VIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLS
CQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVSNRRPYRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEELPVLR
RRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNRKCIPGSIKLDSEEDMPFEDCTNDPESEHDLLLNGCLKSLAFDSEHSADE
KEKPCAKSRARKSSDNPKRTSVKKGHIQFEAHKDERRGKIPENLGLNFISGDISDTQASNELSRIANSLTGSNTAPGSFLFSSCGKNTAK
KEFETSNGDSLLGLPEGALISKCSREKNKPQRSLVCGSKVKLCYIGAGDEEKRSDSISICTTSDDGSSDLDPIEHSSESDNSVLEIPDAF
DRTENMLSMQKNEKIKYSRFAATNTRVKAKQKPLISNSHTDHLMGCTKSAEPGTETSQVNLSDLKASTLVHKPQSDFTNDALSPKFNLSS
SISSENSLIKGGAANQALLHSKSKQPKFRSIKCKHKENPVMAEPPVINEECSLKCCSSDTKGSPLASISKSGKVDGLKLLNNMHEKTRDS
SDIETAVVKHVLSELKELSYRSLGEDVSDSGTSKPSKPLLFSSASSQNHIPIEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSP
GRGDCSTNSPVGVSKVLVSGGSTHNSEKKGDGTQNSANPSPSGGDSALSGELSASLPGLLSDKRDLPASGKSRSDCVTRRNCGRSKPSSK
LRDAFSAQMVKNTVNRKALKTERKRKLNQLPSVTLDAVLQGDRERGGSLRGGAEDPSKEDPLQIMGHLTSEDGDHFSDVHFDSKVKQSDP
GKISEKGLSFENGKGPELDSVMNSENDELNGVNQVVPKKRWQRLNQRRTKPRKRMNRFKEKENSECAFRVLLPSDPVQEGRDEFPEHRTP
SASILEEPLTEQNHADCLDSAGPRLNVCDKSSASIGDMEKEPGIPSLTPQAELPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKKKQK
KVQEQVHKVSSRCEEESLLARGRSSAQNKQVDENSLISTKEEPPVLEREAPFLEGPLAQSELGGGHAELPQLTLSVPVAPEVSPRPALES
EELLVKTPGNYESKRQRKPTKKLLESNDLDPGFMPKKGDLGLSKKCYEAGHLENGITESCATSYSKDFGGGTTKIFDKPRKRKRQRHAAA
KMQCKKVKNDDSSKEIPGSEGELMPHRTATSPKETVEEGVEHDPGMPASKKMQGERGGGAALKENVCQNCEKLGELLLCEAQCCGAFHLE
CLGLTEMPRGKFICNECRTGIHTCFVCKQSGEDVKRCLLPLCGKFYHEECVQKYPPTVMQNKGFRCSLHICITCHAANPANVSASKGRLM
RCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTPRRGCRNHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCK
AGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMGKGVDGTYKKALQ
EAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGG
RCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFM
NHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIATEEKSKKFKKKQQGKRRT
QGEITKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGR
LSCTEHDPCGPNPLEPGEIREYVPPPVPLPPGPSTHLAEQSTGMAAQAPKMSDKPPADTNQMLSLSKKALAGTCQRPLLPERPLERTDSR
PQPLDKVRDLAGSGTKSQSLVSSQRPLDRPPAVAGPRPQLSDKPSPVTSPSSSPSVRSQPLERPLGTADPRLDKSIGAASPRPQSLEKTS
VPTGLRLPPPDRLLITSSPKPQTSDRPTDKPHASLSQRLPPPEKVLSAVVQTLVAKEKALRPVDQNTQSKNRAALVMDLIDLTPRQKERA
ASPHQVTPQADEKMPVLESSSWPASKGLGHMPRAVEKGCVSDPLQTSGKAAAPSEDPWQAVKSLTQARLLSQPPAKAFLYEPTTQASGRA
SAGAEQTPGPLSQSPGLVKQAKQMVGGQQLPALAAKSGQSFRSLGKAPASLPTEEKKLVTTEQSPWALGKASSRAGLWPIVAGQTLAQSC
WSAGSTQTLAQTCWSLGRGQDPKPEQNTLPALNQAPSSHKCAESEQK

--------------------------------------------------------------
>15062_15062_3_CDH23-NSD1_CDH23_chr10_73501678_ENST00000224721_NSD1_chr5_176618885_ENST00000439151_length(transcript)=16785nt_BP=4865nt
GAGCCATGGGGCGCCATGTTGCCACCAGCTGCCACGTGGCCTGGCTTTTGGTGCTGATCTCTGGATGCTGGGGCCAGGTGAACCGGCTGC
CCTTCTTCACCAACCACTTCTTTGATACATACCTGCTGATCAGCGAGGACACGCCTGTGGGTTCTTCTGTGACCCAGTTGCTGGCCCAAG
ACATGGACAATGACCCCCTGGTGTTTGGCGTGTCTGGGGAGGAGGCCTCTCGCTTCTTTGCAGTGGAGCCTGACACTGGCGTGGTGTGGC
TCCGGCAGCCACTGGACAGAGAGACCAAGTCAGAGTTCACCGTGGAGTTCTCTGTCAGCGACCACCAGGGGGTGATCACACGGAAGGTGA
ACATCCAGGTTGGGGATGTGAATGACAACGCGCCCACATTTCACAATCAGCCCTACAGCGTCCGCATCCCTGAGGTAGGAGCCACTGGGA
ATACACCAGTGGGGACGCCCATCTTCATCGTGAATGCCACAGACCCCGACTTGGGGGCAGGGGGCAGCGTCCTCTACTCCTTCCAGCCCC
CCTCCCAATTCTTCGCCATTGACAGCGCCCGCGGTATCGTCACAGTGATCCGGGAGCTGGACTACGAGACCACACAGGCCTACCAGCTCA
CGGTCAACGCCACAGATCAAGACAAGACCAGGCCTCTGTCCACCCTGGCCAACTTGGCCATCATCATCACAGATGTCCAGGACATGGACC
CCATCTTCATCAACCTGCCTTACAGCACCAACATCTACGAGCATTCTCCTCCGGGCACGACGGTGCGCATCATCACCGCCATAGACCAGG
ATAAAGGACGTCCCCGGGGCATTGGCTACACCATCGTTTCAGGGAATACCAACAGCATCTTTGCCCTGGACTACATCAGCGGAGTGCTGA
CCTTGAATGGCCTGCTGGACCGGGAGAACCCCCTGTACAGCCATGGCTTCATCCTGACTGTGAAGGGCACGGAGCTGAACGATGACCGCA
CCCCATCTGACGCTACAGTCACCACGACCTTCAATATCCTGGTTATTGACATCAATGACAATGCCCCGGAGTTCAACAGCTCCGAGTACA
GCGTGGCCATCACTGAGCTGGCACAGGTCGGCTTTGCCCTTCCACTCTTCATCCAGGTGGTGGACAAGGATGAGAATTTGGGCCTGAACA
GCATGTTTGAGGTGTACTTGGTGGGGAACAACTCCCACCACTTCATCATCTCCCCGACCTCCGTCCAGGGGAAGGCGGACATTCGTATTC
GGGTGGCCATCCCACTGGACTACGAGACCGTGGACCGCTACGACTTTGATCTCTTTGCCAATGAGAGTGTGCCTGACCATGTGGGCTATG
CCAAGGTGAAGATCACTCTCATCAATGAAAATGACAACCGGCCCATCTTCAGCCAGCCACTGTACAACATCAGCCTGTACGAGAACGTCA
CCGTGGGGACCTCTGTGCTGACAGTCCTGGCAACTGACAATGATGCAGGCACCTTTGGGGAAGTCAGCTACTTCTTCAGTGATGACCCTG
ACAGGTTCTCGCTGGACAAGGACACGGGACTCATCATGCTGATTGCCAGGCTGGACTATGAGCTCATCCAGCGCTTCACCCTGACGATCA
TTGCCCGGGACGGGGGCGGCGAGGAGACCACAGGCCGGGTCAGGATCAATGTGTTGGATGTCAACGACAACGTGCCCACCTTCCAGAAGG
ATGCCTACGTGGGTGCTCTGCGGGAGAACGAGCCTTCTGTCACACAGCTGGTGCGGCTCCGGGCAACAGATGAAGACTCCCCTCCCAACA
ACCAGATCACCTACAGCATTGTCAGTGCATCTGCCTTTGGCAGCTACTTCGACATCAGCCTGTACGAGGGCTATGGAGTGATCAGCGTCA
GTCGCCCCCTGGATTATGAACAGATATCCAATGGGCTGATTTATCTGACGGTCATGGCCATGGATGCTGGCAACCCCCCTCTCAACAGCA
CCGTCCCTGTCACCATCGAGGTGTTTGATGAGAATGACAACCCTCCCACCTTCAGCAAGCCCGCCTACTTCGTCTCCGTGGTGGAGAACA
TCATGGCAGGAGCCACGGTGCTGTTCCTGAATGCCACAGACCTGGACCGCTCCCGGGAGTACGGCCAGGAGTCCATCATCTACTCCTTGG
AAGGCTCCACCCAGTTTCGGATCAATGCCCGCTCAGGGGAAATCACCACCACGTCTCTGCTTGACCGAGAGACCAAGTCTGAATACATCC
TCATCGTTCGCGCAGTGGACGGGGGTGTGGGCCACAACCAGAAAACTGGCATCGCCACCGTAAACATCACCCTCCTGGACATCAATGACA
ACCACCCCACGTGGAAGGACGCACCCTACTACATCAACCTGGTGGAGATGACCCCTCCAGACTCTGATGTGACCACGGTGGTGGCTGTTG
ACCCAGACCTGGGGGAGAATGGCACCCTGGTGTACAGCATCCAGCCACCCAACAAGTTCTACAGCCTCAACAGCACCACGGGCAAGATCC
GCACCACCCACGCCATGCTGGACCGGGAGAACCCCGACCCCCATGAGGCCGAGCTGATGCGCAAAATCGTCGTCTCTGTTACTGACTGTG
GCAGGCCCCCTCTGAAAGCCACCAGCAGTGCCACAGTGTTTGTGAACCTCTTGGATCTCAATGACAATGACCCCACCTTTCAGAACCTGC
CTTTTGTGGCCGAGGTGCTTGAAGGCATCCCGGCGGGGGTCTCCATCTACCAAGTGGTGGCCATCGACCTCGATGAGGGCCTGAACGGCC
TGGTGTCCTACCGCATGCCGGTGGGCATGCCCCGCATGGACTTCCTCATCAACAGCAGCAGCGGCGTGGTGGTCACCACCACCGAGCTGG
ACCGCGAGCGCATCGCGGAGTACCAGCTGCGGGTGGTGGCCAGTGATGCAGGCACGCCCACCAAGAGCTCCACCAGCACGCTCACCATCC
ATGTGCTGGATGTGAACGACGAGACGCCCACCTTCTTCCCGGCCGTGTACAATGTGTCTGTGTCCGAGGACGTGCCACGCGAGTTCCGGG
TGGTCTGGCTGAACTGCACGGACAACGACGTGGGCCTCAATGCAGAGCTCAGCTACTTCATCACAGGTGGCAACGTGGATGGGAAGTTCA
GCGTGGGTTACCGCGATGCCGTTGTGAGAACCGTGGTGGGCCTGGACCGGGAGACCACAGCCGCCTACATGCTCATCCTGGAGGCCATCG
ACAACGGCCCTGTAGGGAAGCGACACACGGGCACAGCCACCGTGTTCGTCACTGTCCTGGATGTGAATGACAACCGGCCCATCTTTCTGC
AGAGCAGCTATGAGGCCAGCGTCCCTGAGGACATCCCTGAAGGCCACAGCATCTTGCAGCTGAAAGCCACGGACGCAGATGAGGGCGAGT
TTGGGCGTGTGTGGTACCGCATCCTCCATGGTAACCATGGCAACAACTTCCGGATCCATGTCAGCAATGGGCTCCTGATGCGAGGGCCCC
GGCCCCTGGACCGGGAGCGGAACTCATCCCACGTGCTGATAGTGGAGGCCTACAACCACGACCTGGGCCCCATGCGGAGCTCCGTCAGGG
TGATTGTGTACGTGGAGGACATCAACGATGAGGCCCCCGTGTTCACACAGCAGCAGTACAGCCGTCTGGGGCTTCGAGAGACCGCAGGCA
TTGGAACGTCAGTCATCGTGGTCCAAGCCACAGACCGAGACTCTGGGGATGGTGGCCTGGTGAACTACCGCATCCTGTCGGGCGCAGAGG
GGAAGTTTGAGATTGACGAGAGCACAGGGCTTATCATCACCGTGAATTACCTGGACTACGAGACCAAGACCAGCTACATGATGAATGTGT
CGGCCACTGACCAGGCCCCGCCCTTCAACCAGGGCTTCTGCAGCGTCTACATCACTCTGCTCAACGAGCTGGACGAGGCCGTGCAGTTCT
CCAATGCCTCATACGAGGCTGCCATCCTGGAGAATCTGGCACTGGGTACTGAGATTGTGCGGGTCCAGGCCTACTCCATCGACAACCTCA
ACCAAATCACGTACCGCTTCAACGCCTACACCAGCACCCAGGCCAAAGCCCTCTTCAAGATAGACGCCATCACGGGTGTGATCACAGTCC
AGGGCCTGGTGGACCGTGAGAAGGGCGACTTCTATACCTTGACAGTGGTGGCAGATGACGGCGGCCCCAAGGTGGACTCCACCGTGAAGG
TCTACATCACTGTGCTGGACGAGAATGACAACAGCCCCCGGTTTGACTTCACCTCCGACTCGGCGGTCAGCATACCCGAGGACTGCCCTG
TGGGCCAGCGAGTGGCTACTGTCAAGGCCTGGGACCCTGATGCTGGCAGCAATGGGCAGGTGGTCTTCTCCCTGGCCTCTGGCAACATCG
CGGGGGCCTTTGAGATCGTCACCACCAATGACTCCATTGGCGAAGTGTTTGTGGCCAGGCCCCTGGACAGAGAAGAGCTGGATCACTACA
TCCTCCAGGTTGTGGCTTCTGACCGAGGCACCCCTCCACGGAAGAAGGACCACATCCTGCAGGTGACCATCCTGGACATCAATGACAACC
CTCCAGTCATCGAGAGCCCCTTTGGATACAATGTCAGTGTGAATGAGAACGTGGGTGGAGGTACTGCTGTGGTCCAGGTGAGAGCCACTG
ACCGTGACATCGGGATCAACAGTGTTCTGTCCTACTACATCACCGAGGGCAACAAGGACATGGCCTTCCGCATGGACCGCATCAGCGGTG
AGATCGCCACACGGCCTGCCCCGCCTGACCGCGAGCGCCAGAGCTTCTACCACCTGGTGGCCACTGTGGAGGACGAGGGCACCCCAACCC
TGTCGTGTCAACCTAAGAAAAAGTCTACGCCACTGAAGTATGAAGTTGGAGATCTCATCTGGGCAAAATTCAAGAGACGCCCATGGTGGC
CCTGCAGGATTTGTTCTGATCCGTTGATTAACACACATTCAAAAATGAAAGTTTCCAACCGGAGGCCCTATCGGCAGTACTACGTGGAGG
CTTTTGGAGATCCTTCTGAGAGAGCCTGGGTGGCTGGAAAAGCAATCGTCATGTTTGAAGGCAGACATCAATTCGAAGAGCTACCTGTCC
TTAGGAGAAGAGGGAAACAGAAAGAAAAAGGATATAGGCATAAGGTTCCTCAGAAAATTTTGAGTAAATGGGAAGCCAGTGTTGGACTTG
CAGAACAGTATGATGTTCCCAAGGGGTCAAAGAACCGAAAATGTATTCCTGGTTCAATCAAGTTGGACAGTGAAGAAGATATGCCATTTG
AAGACTGCACAAATGATCCTGAGTCAGAACATGACCTGTTGCTTAATGGCTGTTTGAAATCACTGGCTTTTGATTCTGAACATTCTGCAG
ATGAGAAGGAAAAGCCTTGCGCTAAATCTCGAGCCAGAAAGAGCTCTGATAATCCAAAAAGGACTAGTGTGAAAAAGGGCCACATACAAT
TTGAAGCACATAAAGATGAACGGAGGGGAAAGATTCCAGAGAACCTTGGCCTAAACTTTATCTCTGGGGATATATCTGATACGCAGGCCT
CTAATGAACTTTCCAGGATAGCAAATAGCCTCACAGGGTCCAACACTGCCCCAGGAAGTTTTCTGTTTTCTTCCTGTGGAAAAAACACTG
CAAAGAAAGAATTTGAGACTTCAAATGGTGACTCTTTATTGGGCTTGCCTGAGGGTGCTTTGATCTCAAAGTGTTCTCGAGAGAAGAATA
AACCCCAACGAAGCCTGGTGTGTGGTTCAAAAGTGAAGCTCTGCTATATTGGAGCAGGTGATGAGGAAAAGCGAAGTGATTCCATTAGTA
TCTGTACCACTTCTGATGATGGAAGCAGTGACCTGGATCCCATAGAACACAGCTCAGAGTCTGATAACAGTGTCCTTGAAATTCCAGATG
CTTTCGATAGAACAGAGAACATGTTATCTATGCAGAAAAATGAAAAGATAAAGTATTCTAGGTTTGCTGCCACAAACACTAGGGTAAAAG
CAAAACAGAAGCCTCTCATTAGTAACTCACATACAGACCACTTAATGGGTTGTACTAAGAGTGCAGAGCCTGGAACCGAGACGTCTCAGG
TTAATCTCTCTGATCTGAAGGCATCTACTCTTGTTCACAAACCCCAGTCAGATTTTACAAATGATGCTCTCTCTCCAAAATTCAACCTGT
CATCAAGCATATCCAGTGAGAACTCGTTAATAAAGGGTGGGGCAGCAAATCAAGCTCTATTACATTCGAAAAGCAAACAGCCCAAGTTCC
GAAGTATAAAGTGCAAACACAAAGAAAATCCAGTTATGGCAGAACCCCCAGTTATAAATGAGGAGTGCAGTTTGAAATGCTGCTCTTCTG
ATACCAAAGGCTCTCCTTTGGCCAGCATTTCTAAAAGTGGGAAAGTGGATGGTCTAAAACTACTGAACAATATGCATGAGAAAACCAGGG
ATTCAAGTGACATAGAAACAGCAGTGGTGAAACATGTTTTATCCGAGTTGAAGGAACTCTCTTACAGATCCTTAGGTGAGGATGTCAGTG
ACTCTGGAACATCAAAGCCATCAAAACCATTACTTTTCTCTTCTGCTTCTAGTCAGAATCACATACCTATTGAACCAGACTACAAATTCA
GTACATTGCTAATGATGTTGAAAGATATGCATGATAGTAAGACGAAGGAGCAGCGGTTGATGACTGCTCAAAACCTGGTCTCTTACCGGA
GTCCTGGTCGTGGGGACTGTTCTACTAATAGTCCTGTAGGAGTCTCTAAGGTTTTGGTTTCAGGAGGCTCCACACACAATTCAGAGAAAA
AGGGAGATGGCACTCAGAACTCCGCCAATCCTAGCCCTAGTGGGGGTGACTCTGCATTATCTGGCGAGTTGTCTGCTTCCCTACCTGGCT
TACTGTCCGACAAGAGAGACCTCCCTGCTTCTGGTAAAAGTCGTTCAGACTGTGTTACTAGGCGCAACTGTGGACGATCAAAGCCTTCAT
CCAAATTGCGAGATGCTTTTTCAGCCCAAATGGTAAAGAACACAGTGAACCGTAAAGCCTTAAAGACCGAGCGCAAAAGAAAACTGAATC
AGCTTCCAAGTGTGACTCTTGATGCTGTACTGCAGGGAGACCGAGAACGTGGAGGTTCATTGAGAGGTGGGGCAGAAGATCCTAGTAAAG
AGGATCCCCTTCAGATAATGGGCCACTTAACAAGTGAAGATGGTGACCATTTTTCTGATGTGCATTTCGATAGCAAGGTTAAGCAATCTG
ATCCTGGTAAAATTTCTGAAAAAGGACTCTCTTTTGAAAACGGAAAAGGCCCAGAGCTGGACTCTGTAATGAACAGTGAGAATGATGAAC
TCAATGGTGTAAATCAAGTGGTGCCTAAAAAGCGGTGGCAGCGTTTAAACCAAAGGCGCACTAAACCTCGTAAGCGCATGAACAGATTTA
AAGAGAAAGAAAACTCTGAGTGTGCCTTTAGGGTCTTACTTCCTAGTGACCCTGTGCAGGAGGGGCGGGATGAGTTTCCAGAGCATAGAA
CTCCTTCAGCAAGCATACTTGAGGAACCACTGACAGAGCAAAATCATGCTGACTGCTTAGATTCAGCTGGGCCACGGTTAAATGTTTGTG
ATAAATCCAGTGCCAGCATTGGTGACATGGAAAAGGAGCCAGGAATTCCCAGTTTGACACCACAGGCTGAGCTCCCTGAACCAGCTGTGC
GGTCAGAGAAGAAACGCCTTAGGAAGCCAAGCAAGTGGCTTTTGGAATATACAGAAGAATATGATCAGATATTTGCTCCTAAGAAAAAAC
AAAAGAAGGTACAGGAGCAGGTGCACAAGGTAAGTTCCCGCTGTGAAGAGGAAAGCCTTCTAGCCCGAGGTCGATCTAGTGCTCAGAACA
AGCAGGTGGACGAGAATTCTTTGATTTCAACCAAAGAAGAGCCTCCAGTTCTTGAAAGGGAGGCTCCGTTTTTGGAGGGCCCCTTGGCTC
AGTCAGAACTTGGAGGTGGACATGCTGAGTTGCCGCAGCTGACCTTGTCTGTGCCTGTGGCTCCGGAAGTCTCTCCACGGCCTGCCCTTG
AGTCTGAGGAATTGCTAGTTAAAACGCCAGGAAATTATGAAAGTAAACGTCAAAGAAAACCAACTAAGAAACTTCTTGAATCCAATGATT
TAGACCCTGGATTTATGCCCAAGAAGGGGGACCTTGGCCTTTCTAAAAAGTGCTATGAAGCTGGTCACCTGGAGAATGGCATAACTGAAT
CTTGTGCCACATCTTATTCAAAAGATTTTGGTGGAGGCACTACCAAGATATTTGACAAGCCAAGGAAGCGAAAACGACAGAGGCATGCTG
CAGCCAAGATGCAGTGTAAAAAAGTGAAAAATGATGACTCGTCAAAAGAGATTCCAGGCTCAGAGGGAGAACTAATGCCTCACAGGACGG
CCACAAGCCCCAAGGAGACTGTTGAGGAAGGTGTAGAACACGATCCCGGGATGCCTGCCTCTAAAAAAATGCAGGGTGAACGCGGTGGAG
GAGCTGCACTCAAGGAGAATGTCTGTCAGAATTGTGAAAAATTGGGTGAGCTGCTGTTATGTGAGGCTCAGTGCTGTGGGGCTTTCCACC
TGGAGTGCCTTGGATTGACTGAGATGCCAAGAGGAAAATTTATCTGCAATGAATGTCGCACAGGAATCCATACCTGTTTTGTATGTAAGC
AGAGTGGGGAAGATGTTAAAAGGTGCCTTCTACCCTTGTGTGGAAAGTTTTACCATGAAGAGTGTGTCCAGAAGTACCCACCCACTGTTA
TGCAGAACAAGGGCTTCCGGTGCTCCCTCCACATCTGTATAACCTGTCATGCTGCTAATCCAGCCAATGTTTCTGCATCTAAAGGTCGGT
TGATGCGCTGTGTCCGCTGTCCTGTGGCATACCACGCCAATGACTTTTGCCTGGCTGCTGGGTCAAAGATCCTTGCATCTAATAGTATCA
TCTGCCCTAATCACTTTACCCCTAGGCGGGGCTGCCGAAATCATGAGCATGTTAATGTTAGCTGGTGCTTTGTGTGCTCAGAAGGAGGCA
GCCTTCTGTGCTGTGATTCTTGCCCTGCTGCTTTTCATCGTGAATGCCTGAACATTGATATCCCTGAAGGAAACTGGTATTGCAATGACT
GTAAAGCAGGCAAAAAGCCACACTACAGGGAGATTGTCTGGGTAAAAGTTGGACGATACAGGTGGTGGCCAGCTGAGATCTGCCATCCTC
GAGCTGTTCCTTCCAACATTGATAAGATGAGACATGATGTGGGAGAGTTCCCAGTCCTCTTTTTTGGATCTAATGACTATTTGTGGACTC
ACCAGGCCCGAGTCTTCCCTTACATGGAGGGTGACGTGAGCAGCAAGGATAAGATGGGCAAAGGAGTGGATGGGACATATAAAAAAGCTC
TTCAGGAAGCTGCAGCAAGGTTTGAGGAATTAAAGGCCCAAAAAGAGCTAAGACAGCTGCAGGAAGACCGAAAGAATGACAAGAAGCCAC
CACCTTATAAACATATAAAGGTAAACCGTCCTATTGGCAGGGTACAGATCTTCACTGCAGACTTATCTGAAATACCCCGTTGCAACTGTA
AAGCTACTGATGAGAACCCCTGTGGGATAGACTCTGAATGCATCAACCGCATGCTGCTCTATGAGTGCCACCCCACAGTGTGTCCTGCCG
GAGGGCGCTGTCAAAACCAGTGCTTTTCCAAGCGCCAATATCCAGAGGTTGAAATTTTCCGCACATTACAGCGGGGTTGGGGTCTACGGA
CAAAAACAGATATTAAAAAGGGTGAATTTGTGAATGAGTATGTGGGTGAGCTTATAGATGAAGAAGAATGCAGAGCTCGAATTCGCTATG
CTCAAGAACATGATATCACTAATTTCTATATGCTCACCCTAGACAAAGACCGAATCATTGATGCTGGTCCCAAAGGAAACTATGCTCGGT
TCATGAATCATTGCTGCCAGCCCAACTGTGAAACACAGAAGTGGTCTGTGAATGGAGATACCCGTGTAGGCCTTTTTGCACTAAGTGACA
TTAAAGCAGGCACTGAACTTACCTTCAACTACAACCTAGAATGTCTTGGGAATGGAAAGACTGTTTGCAAATGTGGAGCCCCGAACTGCA
GTGGCTTCTTGGGTGTAAGGCCAAAGAATCAACCCATTGCCACGGAAGAAAAGTCAAAGAAATTCAAGAAGAAGCAACAGGGAAAGCGCA
GGACCCAGGGTGAAATCACAAAGGAGCGAGAAGATGAGTGTTTTAGTTGTGGGGATGCTGGCCAGCTCGTCTCCTGCAAGAAACCAGGCT
GCCCAAAAGTTTACCACGCAGACTGTCTCAATCTGACCAAGCGACCAGCAGGGAAATGGGAATGTCCGTGGCATCAGTGTGACATCTGCG
GGAAGGAAGCAGCCTCCTTCTGTGAGATGTGCCCCAGCTCCTTTTGTAAGCAGCATCGAGAAGGGATGCTTTTCATTTCCAAACTGGATG
GGCGTCTGTCTTGTACTGAGCATGACCCCTGTGGGCCCAATCCTCTGGAACCTGGGGAGATCCGTGAGTATGTGCCTCCCCCAGTACCGC
TGCCTCCAGGGCCAAGCACTCACCTGGCAGAGCAATCAACAGGAATGGCTGCTCAGGCACCCAAAATGTCAGATAAACCTCCTGCTGACA
CCAACCAGATGCTGTCGCTCTCCAAAAAAGCTCTGGCAGGGACTTGTCAGAGGCCATTGCTACCTGAAAGACCTCTTGAGAGAACTGACT
CCAGGCCCCAGCCTTTAGATAAGGTCAGAGACCTCGCTGGGTCAGGGACCAAATCCCAATCCTTGGTTTCCAGCCAGAGGCCACTGGACA
GGCCACCAGCAGTGGCAGGACCAAGACCCCAGCTAAGCGACAAACCCTCTCCAGTGACCAGCCCAAGCTCCTCACCCTCAGTCAGGTCCC
AACCACTGGAAAGACCTCTGGGGACGGCTGACCCAAGGCTGGATAAATCCATAGGTGCTGCCAGCCCAAGGCCCCAGTCACTGGAGAAAA
CCTCAGTTCCCACTGGCCTGAGACTTCCGCCGCCAGACAGACTGCTCATTACTAGCAGTCCCAAACCCCAGACTTCAGACAGGCCTACTG
ACAAACCCCATGCCTCTTTGTCCCAGAGACTCCCACCTCCTGAGAAAGTACTATCAGCTGTGGTCCAGACCCTTGTAGCTAAAGAAAAAG
CACTGAGGCCTGTGGACCAGAATACTCAGTCAAAAAATAGAGCTGCTTTGGTGATGGATCTCATAGACCTAACTCCTCGCCAGAAGGAGC
GGGCAGCTTCACCTCATCAGGTCACACCACAGGCTGATGAGAAGATGCCAGTGTTGGAGTCAAGTTCATGGCCTGCCAGCAAAGGTCTGG
GGCATATGCCGAGAGCTGTTGAGAAAGGCTGTGTGTCAGATCCTCTTCAGACATCTGGGAAAGCAGCAGCCCCTTCAGAGGACCCCTGGC
AAGCTGTTAAATCACTCACCCAGGCCAGACTTCTTTCTCAGCCTCCTGCCAAGGCCTTTTTATATGAGCCAACAACTCAGGCCTCAGGAA
GAGCTTCTGCAGGGGCTGAGCAGACCCCAGGGCCTCTTAGCCAATCCCCGGGCCTGGTGAAGCAGGCGAAGCAGATGGTCGGAGGCCAGC
AACTACCTGCACTTGCCGCCAAGAGTGGGCAATCTTTTAGGTCTCTCGGGAAGGCCCCAGCCTCCCTCCCCACTGAAGAAAAGAAGTTGG
TAACCACAGAGCAAAGTCCCTGGGCCCTGGGAAAAGCCTCATCACGGGCAGGGCTCTGGCCCATAGTGGCTGGACAGACACTGGCACAGT
CTTGCTGGTCTGCTGGGAGCACACAGACATTGGCACAGACTTGCTGGTCTCTTGGAAGAGGGCAAGACCCCAAACCAGAGCAAAATACAC
TTCCAGCTCTTAACCAGGCTCCTTCCAGTCACAAGTGTGCAGAATCAGAACAGAAGTAGTACCAATCAATGTCACATGAACAAACAAGCT
GCCCCCAGGGTACCATTTGGGGAGGGGAAATCTTTTCTTTCTTTCCCCCTTAAAAAAAAACACATCTGCCCCGAACACTTTCCCACTGTT
ATTCTTTCCTCATATCCCAACACTCAGAACTCTTGTGACATTAGCCAGTGGGGGCTTATGGTTGTGTGAACCATGTATGAAAATCCAGTG
GGCCCCAACCAAGGAGACAGACAGACTTGGGTCTCTTTCCCCCAACTTTTCCACATGGTCATCGTGAAATAAAAAGTCCACTCTGGAGTC
AAGTATGGAATTCAATTCCGCTGGTCAGGTTGGAAGGTATAGGGGCTCTCAAAGCGATTTCCCCAACCAGACAGAGCCCCATTGAGGGCA
CCTAGGAACCCTTGGGAGGAAATGGTGTTCTTTCAAATCAGTGGCGATTTCCTGAGCATTCACGTGTTCTAGGCCGGGTGCTAGTCACTG
ATGAGAGATACAGGCCTCATCCCTGTGAGCCTGGATTCCAAGGCTTTCAGGAACCTTTGACCAGGAAGTAACAGGAAGTTCTGAGGGGCC
CTGGGGCTTTAGACTCATTTTGAAATGTCCTTTGTGGCACCAGAAGTGGTTGTGTTGAGGAAGTGTCTCTTGGCTGCGGTGTGCATGGGT
GCGTGTGCATGCGCGCACACTCACAGAGGTCTCCTCTATAGATGCAAGGGTGCTGCATTGAGGCCAGCAAGGCTGTTGGCTGTGGGGTCG
CCGCTGCTGCTTTTGTCTGGGCTGTGCAGAGTCTCAAGATCAGTCCTTGGAGGAGCAGGTGGTCAGGGGCAGTCGGGCTCTGTGCGAATG
TAGATTTCCAGCAGTGGAAGAAGGCATTTGGCAAGCTTCTCTTTCTTTGCTTTTGTTTCTACCTATTTTTCTCTTTGTACATGAATCCAC
CCCATCCCTATTTCCCTAAAACACTCAGGTGCTTTCAGATTTCAGAGCCTCGGGCAGTGGACATAGGGAATCTCTGGCAAGCTCTGAGCT
AGACACACCAGCTTCAGGAAGAGTACCAGATCCTGATGGGAAATTTCTTTTCCCCATTCCTTTTCCCTCCTGAGTGGAGGGAGTCCTCTT
CTTCGCCTCCCTGAGAATTGCTGTGCTCTGTATTGAGAGCACCTGCCTGCTGACTTAGCTCAAAGGCAAGCCAGAACCCTTCCCTGAAGA
CTGGCAAGAGGTGGTGTTTAGAGCAACGTCCAGGCTAAGAGATGACTCCTATTAACTGCTGATTATCTGTTACTGCTGCCCTGAGCTGGG
GCCCAAGGGCTGGGAAATCTGTTGGTGCTACCCTGCCCTACCATTCACCCAGCTCACAGACTGCCAACAGGAAGTGCTGTTTGGCTAGTT
TCCTCCCACTTGTCTACCCCTCCTTTGTCCTTAGACCAACATGTTTACCTCTCTGCTTTGCCAACTTAGCCAGCAGGCCATCCCCGGCCC
TAACGTCTCCTGGCCATTATCTCTTAGTTATGGCTTTCACGCTCTCAATAGGATTCTGTATTTGGTCCCAATTTCCTCAAGTTCTTATTG
AGGTTACTCCCATCAATTCCACGGAGGGAACAGTAGTTATTATAGAAGCATTTGCGCTTTATCTAAAGATTAAAAATAGAATCTGCTTTT
ATTTCCCAAAGTCTGTCTCTGAGGTTGAGACACTTGAACTCAGGCAGAGGGACGAGGCTGGGCAGGGCTGTCCTGAGTTTAGGGGCCTAT
CCCTGCATTTCACTGAGACCTCGGAATCTCCTCTGTGAATTCCACCTGCCTAGTTCTCCCCTTTCATCCTCTCTCTCTTCCCACATCATC
AAAGAGGAAAAGCTCTTTGTTCAAAAGGAAGAGAAAACGTAAAGCATCTTATTTTCTTTTAAAAGAATTTTAAACCATGAAAAAGATATT
TTTAAAGAAATTCACCGAGAACATTAAAGTTCATTATATTAAGTATTTATCATGTGTGAGAATAATAAATATATAACTGCAGCTAGTAGG
TCCCTTTCCCTAATCTTTTAGGTCATATGAGTAGGGTTTGCTTGGTGCCAGTCCTGTGCCCTTTTCTCTCCAGTCATCTGTAGTTGTGAT
CAGAAAAAGGTATCTGCACTGCACTGTCAGAGTCTCCTTTCACTATGTTGTGTGTTAAATTACCGTAGCTCTTTGTTTCATGAAATAAAC
TGTGAATTTGGGGGGGGCGGGGGGAGGGCGTGCAGGCCATGTAAAAATTTTCCGTGGAGAAGTTTGATTCTAAAGTAGCTTCTCTAAAGT
AGGCTTTGGTAGGTAATCAACTTGACAGCAGTCTAGATGTCTCACAGGACAGGAGGGAGTGAGGGAAAGGGGCCATGATTGGCTGCTTTG
TGGTTTTATTTTGGTTCTTTCCATTCTCCGCCATTCATTGGAGGCTTCGTTCCAGACCTGCCTGGGAAAACAGCTTCTGAGCCATTTTGG
GGAGCAGTTCTTCATCTGAATGGATGGACATCTGGGCTTCCTTCAAGGGCCATTGAATGGGAACTAGAAAACCACTGGAAACTAGAAATT
TGAGCTATTGGGCCCACCAGTAGCAGCATGTGATACTAGATGGTTAAAATCATGAAAGCAGTCACTATCCAATTAGAAGCAGAGTCACAA
CAACTGTTGGGAAATGTGACTCTTGGAGGAAGGTGGGGAGGGAGTGGCCTTGCCAGCCCTGTGGGACGTCCCCTGAAGTTTGTAATAAGA
CCCCTTTTCCAAAGGGATGTGAATTGGAGTGAAAAGGAAATCTTTCATCTTAGAAAACTTCTGGTCCTTAACGCAGGGTGGTATTTGGGT
ATGTGCTTGGAAATTGAGATCTCAAGAGTGTTTGCCTTGGAGCCAGCTCCCCAGGAGGCCTTTTCCAGGGACAAGGCAAAAGTTGAAATT
CTCCATGGGTAGCTAGAAAGCCAATACATCTAGCCCTGCTAAGTCAGAAAAAGATTATGAAAAATGTTGAAATTTACATTCAAAGCCTCA
TTTGCTTATCTTGCTGGAGCCAACCCAGTCTAATAGCAAAATAGCTGTCATTGATACAGAAACATCCTCATTTTTAAATGTCTGCTTTAC
CCTGTTACTGAGTTTGAGATGACTTAAATCACTGTGTTGACCCTCTTCTGAACCAAATCTTTAGCATTGATGAAAATAGTTATTTTATTC
TTTACATCCTTCACCCCACACTATGGTCAGGGCATGAAACACCCTGTTGATCCCTTCCCAGGCTCGGCACTGTCTGCTCACTGGAGCCGG
ACTCCCAGGTTGTAATTCTAATGTTGCCTCATGAGAACAGAATGGCAGAAAGTTTAGTCCTGACAGATTCCCCCATAGGGAGTAATGAGG
ACAGCATGAAACTTGGATAGGTTTTACCCTTAGTCCCTATAAGGTGGATTTTACTAAGGTTTTTTAAATGATACTGTCATCCTCTTGGGG
TTTATCAGCCAGGTTAGAGGAGCCCAGTGTCCTAACCTCTCTCAGATCATGGCAGAGAAGGAGCTGCCTCCAGCCCCTTTCTTGCTGAGT
TTCATTTGAGCAGTTCCATGTGTAGACATTCCAAGTCACTGCTTGGTAGTTGCTGTGGGAGCCTGTCATTGGCTATGGCCAGTTAGTTCT
CAGCTGAGCTTCCTAGGGCCAGTGCAACAGGGCCAGAGGCTGCTATAGTGTAAATTGAAATAAGAATAGATCATTGTTTTGTACACACAC
ACAATAAAATGTAATGATGGTGCTAATTTCACGGTATAAATAAGCACTGCCAAGGGTTGAGGGACTGGCAGCTCAAGAAACCCGGGTTCC
TGTTTGGGAGGAGATTTTATGTAGAAAAGTTTGAGGCTTTGTTAAAAGTGGGGAGAAGGAAGATCCTCAGTGAAGCCTGCACCCAACCCT
GGAGTGGCCCAGTGCAATCCAGAGGTGGAAGAGATCCTATATCCAGGTGAAGGTGGCCATTGAGTTTCTCAGGGCTGGGGCCACCTTGTC
CATAGCCTCCGTCCACGCTGCCTGGAGCAGGTTGTTAGAGAGCTCTGGTTGTTGGGTCTTCCTCAGCTCCCTTCTGCCCCTCTCTACCTC
TTCCACTCATGGAAGCCCCTCTACTGCTTATGAAGATTAAGGGTAGTATTTTCTAAGGAAGTGGAAAGAATTAAACTAGAAATCCACAAC
CTCGGAAGAAGTGTTTCGAGTTTAACATGCGCTGTTTCTGCTTATGTGGTTCCTTCTCTAGAGCTGCTTTCCCATGGCTTTCAAAACATC
AGGTTATTGTGGGGCTTCAGGTGTAAGGTCCTGGAAGTTCAGCAAAGTTTCGTGGACAAGACATGGGCACAGAGAGTAGAAGCAGAAATA
AATGGTTCTATGTTTTCAACTTCCAGGGTTGGGGCAGGCCAGAGCAAGGCGGTCTCATCGAGGTGGGTGCTACCTGTGTGTGTGTAGATG
AGTGTGCTGAAGGTGGGGAGGGCAGCACACAGCAGCTCATGGCAGAGCCGCCTCCTAGGTCTTGGCAAAGAGGCAAGCTGACGATAGACA
TCTACCTATATTGTTAAGAAAGGGGTCGGGGGGATCAGCCAAGGTCCATCATTGCTTTTTTGCCGCGCCCCCCCCCCCCCGCCCCCATAG
ATTGTCAGCTGTAAGTGAAACTCCTAGTGAAAAAGAGGGGAGCCCTGTGTTAGGAGTCCCCATAAACATGTACTGTAATTCTTTGTATAT
AGAAAAAAAATTTACTGTAAAGTAAAGTTTAACTTTACTCATATA

>15062_15062_3_CDH23-NSD1_CDH23_chr10_73501678_ENST00000224721_NSD1_chr5_176618885_ENST00000439151_length(amino acids)=4007AA_BP=1618
MGRHVATSCHVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLR
QPLDRETKSEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPEVGATGNTPVGTPIFIVNATDPDLGAGGSVLYSFQPPS
QFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDK
GRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSV
AITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAK
VKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIA
RDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSR
PLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEG
STQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDP
DLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPF
VAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHV
LDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDN
GPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRP
LDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGK
FEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQ
ITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVG
QRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPP
VIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLS
CQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVSNRRPYRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEELPVLR
RRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNRKCIPGSIKLDSEEDMPFEDCTNDPESEHDLLLNGCLKSLAFDSEHSADE
KEKPCAKSRARKSSDNPKRTSVKKGHIQFEAHKDERRGKIPENLGLNFISGDISDTQASNELSRIANSLTGSNTAPGSFLFSSCGKNTAK
KEFETSNGDSLLGLPEGALISKCSREKNKPQRSLVCGSKVKLCYIGAGDEEKRSDSISICTTSDDGSSDLDPIEHSSESDNSVLEIPDAF
DRTENMLSMQKNEKIKYSRFAATNTRVKAKQKPLISNSHTDHLMGCTKSAEPGTETSQVNLSDLKASTLVHKPQSDFTNDALSPKFNLSS
SISSENSLIKGGAANQALLHSKSKQPKFRSIKCKHKENPVMAEPPVINEECSLKCCSSDTKGSPLASISKSGKVDGLKLLNNMHEKTRDS
SDIETAVVKHVLSELKELSYRSLGEDVSDSGTSKPSKPLLFSSASSQNHIPIEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSP
GRGDCSTNSPVGVSKVLVSGGSTHNSEKKGDGTQNSANPSPSGGDSALSGELSASLPGLLSDKRDLPASGKSRSDCVTRRNCGRSKPSSK
LRDAFSAQMVKNTVNRKALKTERKRKLNQLPSVTLDAVLQGDRERGGSLRGGAEDPSKEDPLQIMGHLTSEDGDHFSDVHFDSKVKQSDP
GKISEKGLSFENGKGPELDSVMNSENDELNGVNQVVPKKRWQRLNQRRTKPRKRMNRFKEKENSECAFRVLLPSDPVQEGRDEFPEHRTP
SASILEEPLTEQNHADCLDSAGPRLNVCDKSSASIGDMEKEPGIPSLTPQAELPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKKKQK
KVQEQVHKVSSRCEEESLLARGRSSAQNKQVDENSLISTKEEPPVLEREAPFLEGPLAQSELGGGHAELPQLTLSVPVAPEVSPRPALES
EELLVKTPGNYESKRQRKPTKKLLESNDLDPGFMPKKGDLGLSKKCYEAGHLENGITESCATSYSKDFGGGTTKIFDKPRKRKRQRHAAA
KMQCKKVKNDDSSKEIPGSEGELMPHRTATSPKETVEEGVEHDPGMPASKKMQGERGGGAALKENVCQNCEKLGELLLCEAQCCGAFHLE
CLGLTEMPRGKFICNECRTGIHTCFVCKQSGEDVKRCLLPLCGKFYHEECVQKYPPTVMQNKGFRCSLHICITCHAANPANVSASKGRLM
RCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTPRRGCRNHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCK
AGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMGKGVDGTYKKALQ
EAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGG
RCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFM
NHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIATEEKSKKFKKKQQGKRRT
QGEITKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGR
LSCTEHDPCGPNPLEPGEIREYVPPPVPLPPGPSTHLAEQSTGMAAQAPKMSDKPPADTNQMLSLSKKALAGTCQRPLLPERPLERTDSR
PQPLDKVRDLAGSGTKSQSLVSSQRPLDRPPAVAGPRPQLSDKPSPVTSPSSSPSVRSQPLERPLGTADPRLDKSIGAASPRPQSLEKTS
VPTGLRLPPPDRLLITSSPKPQTSDRPTDKPHASLSQRLPPPEKVLSAVVQTLVAKEKALRPVDQNTQSKNRAALVMDLIDLTPRQKERA
ASPHQVTPQADEKMPVLESSSWPASKGLGHMPRAVEKGCVSDPLQTSGKAAAPSEDPWQAVKSLTQARLLSQPPAKAFLYEPTTQASGRA
SAGAEQTPGPLSQSPGLVKQAKQMVGGQQLPALAAKSGQSFRSLGKAPASLPTEEKKLVTTEQSPWALGKASSRAGLWPIVAGQTLAQSC
WSAGSTQTLAQTCWSLGRGQDPKPEQNTLPALNQAPSSHKCAESEQK

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Fusion Gene PPI Analysis for CDH23-NSD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CDH23-NSD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CDH23-NSD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCDH23C1832394Deafness, Autosomal Recessive 1210CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneCDH23C1832845USHER SYNDROME, TYPE ID7GENOMICS_ENGLAND;UNIPROT
HgeneCDH23C0154860Hereditary retinal dystrophy6CLINGEN
HgeneCDH23C1568247Usher Syndrome, Type I6CLINGEN;GENOMICS_ENGLAND
HgeneCDH23C1848638USHER SYNDROME, TYPE IB (disorder)6CLINGEN
HgeneCDH23C1848639USHER SYNDROME, TYPE IA, FORMERLY6CLINGEN
HgeneCDH23C1848640USHER SYNDROME, TYPE I, FRENCH VARIETY, FORMERLY6CLINGEN
HgeneCDH23C3711374Nonsyndromic Deafness6CLINGEN
HgeneCDH23C0004681Bagassosis1CTD_human
HgeneCDH23C0010481Cushing Syndrome1ORPHANET
HgeneCDH23C0032273Pneumoconiosis1CTD_human
HgeneCDH23C0033375Prolactinoma1ORPHANET
HgeneCDH23C0221406Pituitary-dependent Cushing's disease1ORPHANET
HgeneCDH23C0346303Thyrotroph adenoma1ORPHANET
HgeneCDH23C1384666hearing impairment1GENOMICS_ENGLAND
HgeneCDH23C1863340PITUITARY ADENOMA PREDISPOSITION (disorder)1ORPHANET
HgeneCDH23C2931205Usher syndrome, type 1A1GENOMICS_ENGLAND
HgeneCDH23C4539685PITUITARY ADENOMA 5, MULTIPLE TYPES1UNIPROT
TgeneC0175695Sotos' syndrome20CLINGEN;CTD_human;GENOMICS_ENGLAND
TgeneC4551477SOTOS SYNDROME 18GENOMICS_ENGLAND;UNIPROT
TgeneC0004903Beckwith-Wiedemann Syndrome2GENOMICS_ENGLAND
TgeneC0265210Weaver syndrome2CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneC0004352Autistic Disorder1CTD_human
TgeneC0010606Adenoid Cystic Carcinoma1CTD_human
TgeneC0020796Profound Mental Retardation1CTD_human
TgeneC0023467Leukemia, Myelocytic, Acute1CTD_human;GENOMICS_ENGLAND
TgeneC0025363Mental Retardation, Psychosocial1CTD_human
TgeneC0917816Mental deficiency1CTD_human
TgeneC2931574Chromosome 5, monosomy 5q351ORPHANET
TgeneC3714756Intellectual Disability1CTD_human
TgeneC43045265q35 microduplication syndrome1ORPHANET