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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:FN3K-MYO16 (FusionGDB2 ID:HG64122TG23026) |
Fusion Gene Summary for FN3K-MYO16 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FN3K-MYO16 | Fusion gene ID: hg64122tg23026 | Hgene | Tgene | Gene symbol | FN3K | MYO16 | Gene ID | 64122 | 23026 |
| Gene name | fructosamine 3 kinase | myosin XVI | |
| Synonyms | - | MYAP3|MYR8|Myo16b|NYAP3|PPP1R107 | |
| Cytomap | ('FN3K')('MYO16') 17q25.3 | 13q33.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | fructosamine-3-kinaseprotein-psicosamine 3-kinase FN3Kprotein-ribulosamine 3-kinase FN3K | unconventional myosin-XVIMYO16 variant proteinmyosin heavy chain Myr 8neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 3protein phosphatase 1, regulatory subunit 10 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q9H479 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000300784, ENST00000572813, | ||
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 18 X 19 X 10=3420 |
| # samples | 4 | 21 | |
| ** MAII score | log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(21/3420*10)=-4.02553509210714 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FN3K [Title/Abstract] AND MYO16 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | FN3K(80706853)-MYO16(109535407), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | FN3K-MYO16 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FN3K-MYO16 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FN3K-MYO16 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. FN3K-MYO16 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FN3K | GO:0036525 | protein deglycation | 11522682|11975663 |
| Fusion gene breakpoints across FN3K (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across MYO16 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | CESC | TCGA-FU-A3NI-01A | FN3K | chr17 | 80706853 | - | MYO16 | chr13 | 109535407 | + |
| ChimerDB4 | CESC | TCGA-FU-A3NI-01A | FN3K | chr17 | 80706853 | + | MYO16 | chr13 | 109535407 | + |
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Fusion Gene ORF analysis for FN3K-MYO16 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000300784 | ENST00000457511 | FN3K | chr17 | 80706853 | + | MYO16 | chr13 | 109535407 | + |
| 5CDS-intron | ENST00000300784 | ENST00000467639 | FN3K | chr17 | 80706853 | + | MYO16 | chr13 | 109535407 | + |
| In-frame | ENST00000300784 | ENST00000251041 | FN3K | chr17 | 80706853 | + | MYO16 | chr13 | 109535407 | + |
| In-frame | ENST00000300784 | ENST00000356711 | FN3K | chr17 | 80706853 | + | MYO16 | chr13 | 109535407 | + |
| In-frame | ENST00000300784 | ENST00000357550 | FN3K | chr17 | 80706853 | + | MYO16 | chr13 | 109535407 | + |
| intron-3CDS | ENST00000572813 | ENST00000251041 | FN3K | chr17 | 80706853 | + | MYO16 | chr13 | 109535407 | + |
| intron-3CDS | ENST00000572813 | ENST00000356711 | FN3K | chr17 | 80706853 | + | MYO16 | chr13 | 109535407 | + |
| intron-3CDS | ENST00000572813 | ENST00000357550 | FN3K | chr17 | 80706853 | + | MYO16 | chr13 | 109535407 | + |
| intron-intron | ENST00000572813 | ENST00000457511 | FN3K | chr17 | 80706853 | + | MYO16 | chr13 | 109535407 | + |
| intron-intron | ENST00000572813 | ENST00000467639 | FN3K | chr17 | 80706853 | + | MYO16 | chr13 | 109535407 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000300784 | FN3K | chr17 | 80706853 | + | ENST00000356711 | MYO16 | chr13 | 109535407 | + | 6042 | 653 | 62 | 4870 | 1602 |
| ENST00000300784 | FN3K | chr17 | 80706853 | + | ENST00000251041 | MYO16 | chr13 | 109535407 | + | 2745 | 653 | 62 | 2116 | 684 |
| ENST00000300784 | FN3K | chr17 | 80706853 | + | ENST00000357550 | MYO16 | chr13 | 109535407 | + | 6028 | 653 | 62 | 4870 | 1602 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000300784 | ENST00000356711 | FN3K | chr17 | 80706853 | + | MYO16 | chr13 | 109535407 | + | 0.000836542 | 0.9991635 |
| ENST00000300784 | ENST00000251041 | FN3K | chr17 | 80706853 | + | MYO16 | chr13 | 109535407 | + | 0.001864639 | 0.9981353 |
| ENST00000300784 | ENST00000357550 | FN3K | chr17 | 80706853 | + | MYO16 | chr13 | 109535407 | + | 0.000860164 | 0.9991398 |
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Fusion Genomic Features for FN3K-MYO16 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| FN3K | chr17 | 80706853 | + | MYO16 | chr13 | 109535406 | + | 0.0001485 | 0.99985147 |
| FN3K | chr17 | 80706853 | + | MYO16 | chr13 | 109535406 | + | 0.0001485 | 0.99985147 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for FN3K-MYO16 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:80706853/chr13:109535407) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FN3K | . |
| FUNCTION: Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate (PubMed:11016445, PubMed:11522682, PubMed:11975663). Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions (PubMed:11522682, PubMed:11975663). Involved in intracellular deglycation in erythrocytes (PubMed:11975663). Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function (By similarity). Also able to phosphorylate psicosamines and ribulosamines (PubMed:14633848). {ECO:0000250|UniProtKB:Q9ER35, ECO:0000269|PubMed:11016445, ECO:0000269|PubMed:11522682, ECO:0000269|PubMed:11975663, ECO:0000269|PubMed:14633848}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | FN3K | chr17:80706853 | chr13:109535407 | ENST00000300784 | + | 5 | 6 | 89_91 | 197 | 310.0 | Nucleotide binding | ATP |
| Tgene | MYO16 | chr17:80706853 | chr13:109535407 | ENST00000251041 | 10 | 24 | 1389_1671 | 453 | 941.0 | Compositional bias | Pro-rich | |
| Tgene | MYO16 | chr17:80706853 | chr13:109535407 | ENST00000356711 | 11 | 35 | 1389_1671 | 453 | 1859.0 | Compositional bias | Pro-rich | |
| Tgene | MYO16 | chr17:80706853 | chr13:109535407 | ENST00000357550 | 10 | 34 | 1389_1671 | 453 | 1859.0 | Compositional bias | Pro-rich | |
| Tgene | MYO16 | chr17:80706853 | chr13:109535407 | ENST00000251041 | 10 | 24 | 1147_1176 | 453 | 941.0 | Domain | IQ | |
| Tgene | MYO16 | chr17:80706853 | chr13:109535407 | ENST00000356711 | 11 | 35 | 1147_1176 | 453 | 1859.0 | Domain | IQ | |
| Tgene | MYO16 | chr17:80706853 | chr13:109535407 | ENST00000357550 | 10 | 34 | 1147_1176 | 453 | 1859.0 | Domain | IQ | |
| Tgene | MYO16 | chr17:80706853 | chr13:109535407 | ENST00000251041 | 10 | 24 | 497_504 | 453 | 941.0 | Nucleotide binding | ATP | |
| Tgene | MYO16 | chr17:80706853 | chr13:109535407 | ENST00000356711 | 11 | 35 | 497_504 | 453 | 1859.0 | Nucleotide binding | ATP | |
| Tgene | MYO16 | chr17:80706853 | chr13:109535407 | ENST00000357550 | 10 | 34 | 497_504 | 453 | 1859.0 | Nucleotide binding | ATP | |
| Tgene | MYO16 | chr17:80706853 | chr13:109535407 | ENST00000251041 | 10 | 24 | 1111_1377 | 453 | 941.0 | Region | Involved in CYFIP1- and NCKAP1-binding | |
| Tgene | MYO16 | chr17:80706853 | chr13:109535407 | ENST00000356711 | 11 | 35 | 1111_1377 | 453 | 1859.0 | Region | Involved in CYFIP1- and NCKAP1-binding | |
| Tgene | MYO16 | chr17:80706853 | chr13:109535407 | ENST00000357550 | 10 | 34 | 1111_1377 | 453 | 1859.0 | Region | Involved in CYFIP1- and NCKAP1-binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | MYO16 | chr17:80706853 | chr13:109535407 | ENST00000251041 | 10 | 24 | 401_1145 | 453 | 941.0 | Domain | Myosin motor | |
| Tgene | MYO16 | chr17:80706853 | chr13:109535407 | ENST00000356711 | 11 | 35 | 401_1145 | 453 | 1859.0 | Domain | Myosin motor | |
| Tgene | MYO16 | chr17:80706853 | chr13:109535407 | ENST00000357550 | 10 | 34 | 401_1145 | 453 | 1859.0 | Domain | Myosin motor | |
| Tgene | MYO16 | chr17:80706853 | chr13:109535407 | ENST00000251041 | 10 | 24 | 125_154 | 453 | 941.0 | Repeat | ANK 3 | |
| Tgene | MYO16 | chr17:80706853 | chr13:109535407 | ENST00000251041 | 10 | 24 | 158_189 | 453 | 941.0 | Repeat | ANK 4 | |
| Tgene | MYO16 | chr17:80706853 | chr13:109535407 | ENST00000251041 | 10 | 24 | 191_217 | 453 | 941.0 | Repeat | ANK 5 | |
| Tgene | MYO16 | chr17:80706853 | chr13:109535407 | ENST00000251041 | 10 | 24 | 221_250 | 453 | 941.0 | Repeat | ANK 6 | |
| Tgene | MYO16 | chr17:80706853 | chr13:109535407 | ENST00000251041 | 10 | 24 | 254_283 | 453 | 941.0 | Repeat | ANK 7 | |
| Tgene | MYO16 | chr17:80706853 | chr13:109535407 | ENST00000251041 | 10 | 24 | 59_88 | 453 | 941.0 | Repeat | ANK 1 | |
| Tgene | MYO16 | chr17:80706853 | chr13:109535407 | ENST00000251041 | 10 | 24 | 92_121 | 453 | 941.0 | Repeat | ANK 2 | |
| Tgene | MYO16 | chr17:80706853 | chr13:109535407 | ENST00000356711 | 11 | 35 | 125_154 | 453 | 1859.0 | Repeat | ANK 3 | |
| Tgene | MYO16 | chr17:80706853 | chr13:109535407 | ENST00000356711 | 11 | 35 | 158_189 | 453 | 1859.0 | Repeat | ANK 4 | |
| Tgene | MYO16 | chr17:80706853 | chr13:109535407 | ENST00000356711 | 11 | 35 | 191_217 | 453 | 1859.0 | Repeat | ANK 5 | |
| Tgene | MYO16 | chr17:80706853 | chr13:109535407 | ENST00000356711 | 11 | 35 | 221_250 | 453 | 1859.0 | Repeat | ANK 6 | |
| Tgene | MYO16 | chr17:80706853 | chr13:109535407 | ENST00000356711 | 11 | 35 | 254_283 | 453 | 1859.0 | Repeat | ANK 7 | |
| Tgene | MYO16 | chr17:80706853 | chr13:109535407 | ENST00000356711 | 11 | 35 | 59_88 | 453 | 1859.0 | Repeat | ANK 1 | |
| Tgene | MYO16 | chr17:80706853 | chr13:109535407 | ENST00000356711 | 11 | 35 | 92_121 | 453 | 1859.0 | Repeat | ANK 2 | |
| Tgene | MYO16 | chr17:80706853 | chr13:109535407 | ENST00000357550 | 10 | 34 | 125_154 | 453 | 1859.0 | Repeat | ANK 3 | |
| Tgene | MYO16 | chr17:80706853 | chr13:109535407 | ENST00000357550 | 10 | 34 | 158_189 | 453 | 1859.0 | Repeat | ANK 4 | |
| Tgene | MYO16 | chr17:80706853 | chr13:109535407 | ENST00000357550 | 10 | 34 | 191_217 | 453 | 1859.0 | Repeat | ANK 5 | |
| Tgene | MYO16 | chr17:80706853 | chr13:109535407 | ENST00000357550 | 10 | 34 | 221_250 | 453 | 1859.0 | Repeat | ANK 6 | |
| Tgene | MYO16 | chr17:80706853 | chr13:109535407 | ENST00000357550 | 10 | 34 | 254_283 | 453 | 1859.0 | Repeat | ANK 7 | |
| Tgene | MYO16 | chr17:80706853 | chr13:109535407 | ENST00000357550 | 10 | 34 | 59_88 | 453 | 1859.0 | Repeat | ANK 1 | |
| Tgene | MYO16 | chr17:80706853 | chr13:109535407 | ENST00000357550 | 10 | 34 | 92_121 | 453 | 1859.0 | Repeat | ANK 2 |
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Fusion Gene Sequence for FN3K-MYO16 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >30845_30845_1_FN3K-MYO16_FN3K_chr17_80706853_ENST00000300784_MYO16_chr13_109535407_ENST00000251041_length(transcript)=2745nt_BP=653nt GCCCCGCAGCGCCTCAGCCGACAGGGGCTTCCGAGCGAGCAGAGTCCCGCGCCCCGCACTCCATGGAGCAGCTGCTGCGCGCCGAGCTGC GCACCGCGACCCTGCGGGCCTTCGGCGGCCCCGGCGCCGGCTGCATCAGCGAGGGCCGAGCCTACGACACGGACGCAGGCCCAGTGTTCG TCAAAGTCAACCGCAGGACGCAGGCCCGGCAGATGTTTGAGGGGGAGGTGGCCAGCCTGGAGGCCCTCAGGAGCACGGGCCTGGTGCGGG TGCCGAGGCCCATGAAGGTCATCGACCTGCCGGGAGGTGGGGCCGCCTTTGTGATGGAGCATTTGAAGATGAAGAGCTTGAGCAGTCAAG CATCAAAACTTGGAGAGCAGATGGCAGATTTGCATCTTTACAACCAGAAGCTCAGGGAGAAGTTGAAGGAGGAGGAGAACACAGTGGGCC GAAGAGGTGAGGGTGCTGAGCCTCAGTATGTGGACAAGTTCGGCTTCCACACGGTGACGTGCTGCGGCTTCATCCCGCAGGTGAATGAGT GGCAGGATGACTGGCCGACCTTTTTCGCCCGGCACCGGCTCCAGGCGCAGCTGGACCTCATTGAGAAGGACTATGCTGACCGAGAGGCAC GAGAACTCTGGTCCCGGCTACAGGTGTCCCAGCTGTATTTCAGCTCCTCAGGGAAGCTGTGTTCCTCGCTGCCTCCTCACCTCTTCTCCT GTGTGGAGAGAGCCTTTCACCAGCTCTTCCGGGAACAGCGGCCTCAGTGTTTCATCCTCAGTGGAGAAAGGGGATCAGGAAAGTCTGAAG CCAGCAAACAAATCATAAGACACCTCACCTGCAGGGCTGGCGCCAGCAGGGCCACACTGGATTCCAGATTCAAACATGTCGTGTGCATCT TAGAAGCCTTTGGACATGCCAAGACCACACTTAATGATTTGTCCAGTTGCTTCATCAAGTATTTTGAACTGCAGTTCTGTGAGAGGAAAC AACAGCTAACCGGAGCCAGAATTTATACATATTTGCTAGAGAAATCCAGACTTGTTTCACAACCTCTTGGCCAGAGCAATTTTCTCATTT TCTACTTGTTGATGGATGGGTTATCTGCTGAAGAAAAATATGGACTTCATCTTAATAATTTATGTGCACACCGGTATTTGAACCAGACCA TACAGGATGATGCATCCACAGGGGAGCGTTCTCTGAACAGGGAGAAATTGGCTGTTTTGAAACGAGCCCTGAATGTAGTTGGCTTCAGCA GCTTGGAGGTGGAGAATCTGTTCGTAATTCTAGCAGCAATATTGCACCTTGGAGACATTCGGTTTACTGCCCTGAATGAGGGGAACTCCG CCTTCGTTTCTGACCTCCAGCTCCTGGAACAAGTGGCTGGAATGTTACAAGTATCAACAGATGAATTGGCATCTGCCTTAACAACTGATA TTCAATATTTTAAAGGGGATATGATAATACGACGACATACCATACAGATTGCTGAGTTTTTCCGAGACCTCTTGGCCAAGTCCCTGTACA GTCGTTTGTTTAGCTTTTTGGTGAATACCATGAATTCTTGCCTCCACAGTCAAGATGAACAGAAAAGCATGCAGACATTGGATATTGGAA TATTGGACATTTTTGGTTTTGAAGAGTTTCAAAAGAATGAATTTGAACAACTTTGTGTCAACATGACCAATGAGAAGATGCACCACTATA TCAATGAAGTGCTTTTTCTCCACGAGCAAGTGGAATGTGTACAAGAGGGAGTTACCATGGAAACAGCATATTCTCCTGGTAACCAGAATG GAGTTTTGGACTTTTTTTTCCAGAAGCCATCTGGATTTCTCACCTTATTGGATGAAGAAAGTCAAATGATTTGGTCAGTGGAATCAAATT TTCCAAAAAAACTACAAAGTCTCCTAGAATCCTCAAACACAAATGCGGTGTACTCCCCCATGAAGGATGGGAATGGGAATGTTGCCCTCA AAGACCACGGTACAGCCTTCACCATCATGCACTACGCAGGAAGGGTAATGTATGATGTTGTTGGGGCGATTGAAAAAAATAAAGACTCCC TTTCACAGAATCTTCTATTTGTAATGAAAAGAGGAAGGTGCTTCTGAGCAAAAGGACAGAATTTACAATGTACCCTTTTGTATTTATACA GGAGGTGTCAGATTTTTTTTTTTGTAAAGGGCTAGAGAATAAATATTTTAGACCTTGTGCACCATAAGATCCTTGTTGCAGTTACTCACC TCTGCTGTTATAATGTGAAAAACAGCTGTAGACAATACAAATGGATGTGACTGTATTCTGATAAAATTTTATTTACAAAAACAGGCAGTG GGCCATGTTTGGCTCAGGAGCCATGATTGCTCACTCACTCTATCATAAAAGCAAAATATTTGTGGTTGCCATCATGTTTTATGAATCTGT GAAATACTTTGATGCTTGTACATATTTATTAAAAGCAAGTGTAATTCATAAATAATAATTTTTATTTGCAGGTACTTTGCTTATAGTATC TAATTCAATTTTCGTAGCATCAAAAAGCTCCCAGTTGAGGAAGATGGTGAGGTCTGTTGTAGAATGTACACAAGCAGAGCTGAGTCTCTG AGACCACTAACCAGGTACAGTCAGGGAGCTTGGAGACAGCTCATAGAGACACACAGCAAATACACTCATTAGTGCCTAAGATTAGAAGTA >30845_30845_1_FN3K-MYO16_FN3K_chr17_80706853_ENST00000300784_MYO16_chr13_109535407_ENST00000251041_length(amino acids)=684AA_BP=196 MEQLLRAELRTATLRAFGGPGAGCISEGRAYDTDAGPVFVKVNRRTQARQMFEGEVASLEALRSTGLVRVPRPMKVIDLPGGGAAFVMEH LKMKSLSSQASKLGEQMADLHLYNQKLREKLKEEENTVGRRGEGAEPQYVDKFGFHTVTCCGFIPQVNEWQDDWPTFFARHRLQAQLDLI EKDYADREARELWSRLQVSQLYFSSSGKLCSSLPPHLFSCVERAFHQLFREQRPQCFILSGERGSGKSEASKQIIRHLTCRAGASRATLD SRFKHVVCILEAFGHAKTTLNDLSSCFIKYFELQFCERKQQLTGARIYTYLLEKSRLVSQPLGQSNFLIFYLLMDGLSAEEKYGLHLNNL CAHRYLNQTIQDDASTGERSLNREKLAVLKRALNVVGFSSLEVENLFVILAAILHLGDIRFTALNEGNSAFVSDLQLLEQVAGMLQVSTD ELASALTTDIQYFKGDMIIRRHTIQIAEFFRDLLAKSLYSRLFSFLVNTMNSCLHSQDEQKSMQTLDIGILDIFGFEEFQKNEFEQLCVN MTNEKMHHYINEVLFLHEQVECVQEGVTMETAYSPGNQNGVLDFFFQKPSGFLTLLDEESQMIWSVESNFPKKLQSLLESSNTNAVYSPM -------------------------------------------------------------- >30845_30845_2_FN3K-MYO16_FN3K_chr17_80706853_ENST00000300784_MYO16_chr13_109535407_ENST00000356711_length(transcript)=6042nt_BP=653nt GCCCCGCAGCGCCTCAGCCGACAGGGGCTTCCGAGCGAGCAGAGTCCCGCGCCCCGCACTCCATGGAGCAGCTGCTGCGCGCCGAGCTGC GCACCGCGACCCTGCGGGCCTTCGGCGGCCCCGGCGCCGGCTGCATCAGCGAGGGCCGAGCCTACGACACGGACGCAGGCCCAGTGTTCG TCAAAGTCAACCGCAGGACGCAGGCCCGGCAGATGTTTGAGGGGGAGGTGGCCAGCCTGGAGGCCCTCAGGAGCACGGGCCTGGTGCGGG TGCCGAGGCCCATGAAGGTCATCGACCTGCCGGGAGGTGGGGCCGCCTTTGTGATGGAGCATTTGAAGATGAAGAGCTTGAGCAGTCAAG CATCAAAACTTGGAGAGCAGATGGCAGATTTGCATCTTTACAACCAGAAGCTCAGGGAGAAGTTGAAGGAGGAGGAGAACACAGTGGGCC GAAGAGGTGAGGGTGCTGAGCCTCAGTATGTGGACAAGTTCGGCTTCCACACGGTGACGTGCTGCGGCTTCATCCCGCAGGTGAATGAGT GGCAGGATGACTGGCCGACCTTTTTCGCCCGGCACCGGCTCCAGGCGCAGCTGGACCTCATTGAGAAGGACTATGCTGACCGAGAGGCAC GAGAACTCTGGTCCCGGCTACAGGTGTCCCAGCTGTATTTCAGCTCCTCAGGGAAGCTGTGTTCCTCGCTGCCTCCTCACCTCTTCTCCT GTGTGGAGAGAGCCTTTCACCAGCTCTTCCGGGAACAGCGGCCTCAGTGTTTCATCCTCAGTGGAGAAAGGGGATCAGGAAAGTCTGAAG CCAGCAAACAAATCATAAGACACCTCACCTGCAGGGCTGGCGCCAGCAGGGCCACACTGGATTCCAGATTCAAACATGTCGTGTGCATCT TAGAAGCCTTTGGACATGCCAAGACCACACTTAATGATTTGTCCAGTTGCTTCATCAAGTATTTTGAACTGCAGTTCTGTGAGAGGAAAC AACAGCTAACCGGAGCCAGAATTTATACATATTTGCTAGAGAAATCCAGACTTGTTTCACAACCTCTTGGCCAGAGCAATTTTCTCATTT TCTACTTGTTGATGGATGGGTTATCTGCTGAAGAAAAATATGGACTTCATCTTAATAATTTATGTGCACACCGGTATTTGAACCAGACCA TACAGGATGATGCATCCACAGGGGAGCGTTCTCTGAACAGGGAGAAATTGGCTGTTTTGAAACGAGCCCTGAATGTAGTTGGCTTCAGCA GCTTGGAGGTGGAGAATCTGTTCGTAATTCTAGCAGCAATATTGCACCTTGGAGACATTCGGTTTACTGCCCTGAATGAGGGGAACTCCG CCTTCGTTTCTGACCTCCAGCTCCTGGAACAAGTGGCTGGAATGTTACAAGTATCAACAGATGAATTGGCATCTGCCTTAACAACTGATA TTCAATATTTTAAAGGGGATATGATAATACGACGACATACCATACAGATTGCTGAGTTTTTCCGAGACCTCTTGGCCAAGTCCCTGTACA GTCGTTTGTTTAGCTTTTTGGTGAATACCATGAATTCTTGCCTCCACAGTCAAGATGAACAGAAAAGCATGCAGACATTGGATATTGGAA TATTGGACATTTTTGGTTTTGAAGAGTTTCAAAAGAATGAATTTGAACAACTTTGTGTCAACATGACCAATGAGAAGATGCACCACTATA TCAATGAAGTGCTTTTTCTCCACGAGCAAGTGGAATGTGTACAAGAGGGAGTTACCATGGAAACAGCATATTCTCCTGGTAACCAGAATG GAGTTTTGGACTTTTTTTTCCAGAAGCCATCTGGATTTCTCACCTTATTGGATGAAGAAAGTCAAATGATTTGGTCAGTGGAATCAAATT TTCCAAAAAAACTACAAAGTCTCCTAGAATCCTCAAACACAAATGCGGTGTACTCCCCCATGAAGGATGGGAATGGGAATGTTGCCCTCA AAGACCACGGTACAGCCTTCACCATCATGCACTACGCAGGAAGGGTAATGTATGATGTTGTTGGGGCGATTGAAAAAAATAAAGACTCCC TTTCACAGAATCTTCTATTTGTAATGAAAACTAGTGAAAATGTCGTGATCAATCATTTGTTCCAGTCGAAATTGTCACAAACAGGATCCC TCGTATCTGCCTATCCTTCCTTTAAATTCCGAGGACATAAGTCTGCCCTGCTCAGTAAGAAAATGACAGCTTCTTCAATTATTGGAGAAA ACAAGAATTATCTAGAACTTAGTAAGTTATTAAAAAAGAAAGGAACTTCTACATTTCTTCAAAGATTGGAACGAGGAGATCCAGTCACCA TAGCATCACAACTCAGGAAATCACTAATGGATATTATTGGAAAACTTCAGAAGTGCACTCCACACTTCATTCATTGCATCAGGCCCAATA ACTCAAAGCTGCCAGATACTTTTGATAATTTTTACGTGTCTGCTCAGCTACAATATATTGGGGTCCTGGAGATGGTGAAGATCTTCCGAT ATGGATACCCTGTTCGCCTTTCCTTCTCGGATTTCCTGTCAAGGTATAAGCCACTGGCTGATACATTCCTGCGTGAGAAGAAGGAACAGT CAGCTGCCGAGCGATGTCGACTTGTTCTCCAGCAGTGTAAATTACAAGGCTGGCAGATGGGAGTCCGAAAAGTGTTTCTAAAATACTGGC ATGCTGACCAACTCAATGATTTGTGCCTACAGTTGCAGAGAAAAATTATAACCTGCCAAAAAGTTATCAGAGGATTTTTAGCACGCCAGC ACCTGCTTCAGAGAATAAGCATCAGACAACAAGAGGTGACTTCTATCAATAGCTTTCTGCAGAACACAGAGGACATGGGGCTGAAAACCT ACGATGCCCTGGTCATTCAGAATGCTTCAGACATTGCCCGGGAAAATGACCGGCTCCGTAGTGAAATGAACGCTCCCTACCATAAAGAGA AGTTAGAGGTCAGGAACATGCAAGAGGAAGGAAGCAAAAGAACCGATGACAAGAGTGGACCCAGGCATTTCCACCCCAGCTCCATGTCAG TCTGCGCGGCCGTGGATGGCCTGGGCCAGTGCCTCGTTGGCCCGTCCATCTGGTCTCCTTCGCTGCACTCGGTGTTCAGCATGGATGACA GCAGCAGCCTCCCGTCTCCACGGAAACAGCCCCCGCCCAAGCCAAAGAGGGACCCCAACACCCGGCTGAGTGCTTCCTATGAGGCTGTGA GCGCCTGCCTCTCCGCGGCCAGGGAAGCGGCCAACGAAGCTCTGGCCCGGCCCAGACCGCACAGCGACGACTACAGCACCATGAAGAAGA TTCCTCCTCGAAAGCCCAAGCGCAGCCCCAACACCAAGCTCAGCGGCTCCTACGAGGAGATATCGGGGTCCCGGCCCGGGGACGCGAGGC CCGCGGGCGCCCCGGGGGCAGCAGCGCGCGTTCTGACCCCCGGGACTCCGCAGTGCGCGCTGCCCCCGGCGGCGCCTCCGGGTGACGAGG ACGACAGCGAGCCTGTGTACATCGAGATGCTGGGGCACGCGGCCAGGCCCGATAGCCCGGACCCCGGGGAGTCCGTGTACGAGGAGATGA AGTGTTGCCTGCCCGACGACGGCGGCCCGGGCGCGGGCTCCTTCCTGCTCCACGGCGCATCGCCGCCCCTGCTCCACCGCGCGCCGGAGG ACGAGGCGGCGGGGCCCCCAGGGGACGCGTGCGACATCCCGCCGCCCTTCCCCAACCTGCTGCCGCACCGGCCGCCCCTGCTGGTGTTCC CCCCGACCCCCGTCACCTGCTCCCCCGCCTCCGACGAGTCGCCCCTGACACCCCTGGAGGTGAAGAAGCTGCCAGTCCTGGAGACCAACC TCAAGTACCCCGTGCAGCCGGAGGGGTCGAGCCCGCTGTCCCCGCAGTACTCCAAGAGCCAGAAGGGCGACGGCGACAGGCCCGCGTCCC CCGGCCTGGCGCTGTTCAACGGGTCCGGCCGAGCCTCCCCGCCGTCCACGCCGCCCCCGCCCCCGCCCCCGCCCGGGCCGCCCCCCGCGC CCTACAGGCCCTGCGCGCACTTGGCCTTCCCGCCGGAGCCCGCCCCGGTGAACGCGGGGAAAGCGGGGCCGAGCGCAGAGGCGCCCAAGG TTCACCCAAAGCCAAACTCTGCCCCCGTGGCCGGGCCCTGCAGCTCCTTCCCCAAGATCCCATATTCCCCCGTGAAGGCCACCAGGGCGG ACGCCAGGAAGGCCGGCTCCAGTGCCTCGCCCCCCGCGCCCTACAGCCCTCCCAGCTCCAGGCCTCTCAGCAGCCCCCTGGACGAGCTCG CCAGCCTCTTCAACTCGGGGAGGAGTGTGCTTCGGAAATCCGCGGCGGGAAGAAAAATCAGGGAAGCAGAAGGTTTTGAAACTAACATGA ACATAAGTAGCCGAGATGACCCTAGTACGTCAGAAATTACTTCCGAGACTCAAGACAGAAATGCAAATAACCATGGAATTCAGTTATCTA ATTCACTATCTAGTGCTATAACTGCTGAAAATGGAAATTCCATCTCAAATGGTTTACCTGAAGAAGATGGATACTCACGGTTGTCTATAA GTGGCACAGGGACTTCGACATTTCAAAGACACAGGGACAGTCACACCACTCAGGTAATCCATCAGCTGAGGCTCTCAGAGAATGAAAGTG TGGCCCTGCAGGAACTCTTGGACTGGAGGAGAAAGCTCTGTGAGGAAGGACAAGACTGGCAGCAGATCCTGCACCACGCTGAGCCCAGGG TGCCTCCCCCACCACCTTGCAAGAAGCCCAGCCTTCTGAAGAAGCCGGAAGGGGCCTCCTGCAACAGGCTGCCGTCTGAGCTCTGGGACA CCACCATTTGATGTGGCCTGAACTGCAGACTTACAAAATAGAACTGCCTACTGATTCCGGGCTGCAACAACAGAAGGCTGCCTTCTGACA TGCGCTGGGGCTTCTCTCCACGCATTTAGACAAAAAAAGCACAGGACACAGACACTAAATATATGAGATCCCGTGTGTGTGTGTGTGTGT TTGTGTGTGTGTGTGTGGGTTCTTTCTTATCCATCTCGTGGTGATACACTCTGATTTTCAAGCTCCTCATTTACGGCTCTGTGCTACCCC TAGGTAGCAAGAGAGAGGCTGGGAAAAGTGTGGACGTGGCCAGAGCGAGAGAGTAGCGGAGGAAAGGAGCAATCCATGCACACTCTGTAC AGTTGTTTTTCTACGGTTCAACAGTCTGTTTATTGTACTTCCAATGGTTTTATTATAATACAGTATACGGGACATATATTTTATTTCTTT GTAGCTACTTGTGTTTTATTGGTATTATAAACCTGATAATTATTTACATGTTTATTACTGTAATTTTATAAATTTATGCAATTGGTGGTG CTTCCTTTCTTCAAAATACAGATTTTAAAAAATCATTTCTAGATTATTTTTTTCCTCCACAGTCCTTTTTTTTCACCTAACGCACCTAAA TCTTGAAACTACATTGTTGTTTTAGCTTCGCCAGTGTCACCCCTTGCAAAACTATGAATTGAGCCCCATGTTTTAGGTGTTACTCATGGA TGAGGAGGCTGTTCTTTCCTATGCCCTGTATTTCTGGATAAGTGGATTGTGTACCCTTTAGTTAAATTTCACCTCCCGACTTCAGCATAG ATCACAGGAAATCACATGGCACACGGTTAAACACGTATGGCTTCAAATCCATAGCCGGTGGTGTAAAATGATCATATTCATTCAAAGGCC TACACAGTACAAATGAGCACGCTGCCATGTACTGGTTTGAGCAGTAGGGGCTGCATCGCACAGCGCTCGTCCCCCGGGACTTACACTGCA TGATTCCCTCACTGTATATCCTCAACCCTCCCATAATGCAAGGCCTTGTTCATTGATGTGCTTTCGTCGGCTGTCGGAAAGTTCTGAGCA GTGGCTCCAGACCACCTTGTCTTGCTACTTGGAACTTTTTATTCATACCAGCCTTTGAAAAGTTACTGTGCCAATAAAGAGGTACAACTG >30845_30845_2_FN3K-MYO16_FN3K_chr17_80706853_ENST00000300784_MYO16_chr13_109535407_ENST00000356711_length(amino acids)=1602AA_BP=196 MEQLLRAELRTATLRAFGGPGAGCISEGRAYDTDAGPVFVKVNRRTQARQMFEGEVASLEALRSTGLVRVPRPMKVIDLPGGGAAFVMEH LKMKSLSSQASKLGEQMADLHLYNQKLREKLKEEENTVGRRGEGAEPQYVDKFGFHTVTCCGFIPQVNEWQDDWPTFFARHRLQAQLDLI EKDYADREARELWSRLQVSQLYFSSSGKLCSSLPPHLFSCVERAFHQLFREQRPQCFILSGERGSGKSEASKQIIRHLTCRAGASRATLD SRFKHVVCILEAFGHAKTTLNDLSSCFIKYFELQFCERKQQLTGARIYTYLLEKSRLVSQPLGQSNFLIFYLLMDGLSAEEKYGLHLNNL CAHRYLNQTIQDDASTGERSLNREKLAVLKRALNVVGFSSLEVENLFVILAAILHLGDIRFTALNEGNSAFVSDLQLLEQVAGMLQVSTD ELASALTTDIQYFKGDMIIRRHTIQIAEFFRDLLAKSLYSRLFSFLVNTMNSCLHSQDEQKSMQTLDIGILDIFGFEEFQKNEFEQLCVN MTNEKMHHYINEVLFLHEQVECVQEGVTMETAYSPGNQNGVLDFFFQKPSGFLTLLDEESQMIWSVESNFPKKLQSLLESSNTNAVYSPM KDGNGNVALKDHGTAFTIMHYAGRVMYDVVGAIEKNKDSLSQNLLFVMKTSENVVINHLFQSKLSQTGSLVSAYPSFKFRGHKSALLSKK MTASSIIGENKNYLELSKLLKKKGTSTFLQRLERGDPVTIASQLRKSLMDIIGKLQKCTPHFIHCIRPNNSKLPDTFDNFYVSAQLQYIG VLEMVKIFRYGYPVRLSFSDFLSRYKPLADTFLREKKEQSAAERCRLVLQQCKLQGWQMGVRKVFLKYWHADQLNDLCLQLQRKIITCQK VIRGFLARQHLLQRISIRQQEVTSINSFLQNTEDMGLKTYDALVIQNASDIARENDRLRSEMNAPYHKEKLEVRNMQEEGSKRTDDKSGP RHFHPSSMSVCAAVDGLGQCLVGPSIWSPSLHSVFSMDDSSSLPSPRKQPPPKPKRDPNTRLSASYEAVSACLSAAREAANEALARPRPH SDDYSTMKKIPPRKPKRSPNTKLSGSYEEISGSRPGDARPAGAPGAAARVLTPGTPQCALPPAAPPGDEDDSEPVYIEMLGHAARPDSPD PGESVYEEMKCCLPDDGGPGAGSFLLHGASPPLLHRAPEDEAAGPPGDACDIPPPFPNLLPHRPPLLVFPPTPVTCSPASDESPLTPLEV KKLPVLETNLKYPVQPEGSSPLSPQYSKSQKGDGDRPASPGLALFNGSGRASPPSTPPPPPPPPGPPPAPYRPCAHLAFPPEPAPVNAGK AGPSAEAPKVHPKPNSAPVAGPCSSFPKIPYSPVKATRADARKAGSSASPPAPYSPPSSRPLSSPLDELASLFNSGRSVLRKSAAGRKIR EAEGFETNMNISSRDDPSTSEITSETQDRNANNHGIQLSNSLSSAITAENGNSISNGLPEEDGYSRLSISGTGTSTFQRHRDSHTTQVIH -------------------------------------------------------------- >30845_30845_3_FN3K-MYO16_FN3K_chr17_80706853_ENST00000300784_MYO16_chr13_109535407_ENST00000357550_length(transcript)=6028nt_BP=653nt GCCCCGCAGCGCCTCAGCCGACAGGGGCTTCCGAGCGAGCAGAGTCCCGCGCCCCGCACTCCATGGAGCAGCTGCTGCGCGCCGAGCTGC GCACCGCGACCCTGCGGGCCTTCGGCGGCCCCGGCGCCGGCTGCATCAGCGAGGGCCGAGCCTACGACACGGACGCAGGCCCAGTGTTCG TCAAAGTCAACCGCAGGACGCAGGCCCGGCAGATGTTTGAGGGGGAGGTGGCCAGCCTGGAGGCCCTCAGGAGCACGGGCCTGGTGCGGG TGCCGAGGCCCATGAAGGTCATCGACCTGCCGGGAGGTGGGGCCGCCTTTGTGATGGAGCATTTGAAGATGAAGAGCTTGAGCAGTCAAG CATCAAAACTTGGAGAGCAGATGGCAGATTTGCATCTTTACAACCAGAAGCTCAGGGAGAAGTTGAAGGAGGAGGAGAACACAGTGGGCC GAAGAGGTGAGGGTGCTGAGCCTCAGTATGTGGACAAGTTCGGCTTCCACACGGTGACGTGCTGCGGCTTCATCCCGCAGGTGAATGAGT GGCAGGATGACTGGCCGACCTTTTTCGCCCGGCACCGGCTCCAGGCGCAGCTGGACCTCATTGAGAAGGACTATGCTGACCGAGAGGCAC GAGAACTCTGGTCCCGGCTACAGGTGTCCCAGCTGTATTTCAGCTCCTCAGGGAAGCTGTGTTCCTCGCTGCCTCCTCACCTCTTCTCCT GTGTGGAGAGAGCCTTTCACCAGCTCTTCCGGGAACAGCGGCCTCAGTGTTTCATCCTCAGTGGAGAAAGGGGATCAGGAAAGTCTGAAG CCAGCAAACAAATCATAAGACACCTCACCTGCAGGGCTGGCGCCAGCAGGGCCACACTGGATTCCAGATTCAAACATGTCGTGTGCATCT TAGAAGCCTTTGGACATGCCAAGACCACACTTAATGATTTGTCCAGTTGCTTCATCAAGTATTTTGAACTGCAGTTCTGTGAGAGGAAAC AACAGCTAACCGGAGCCAGAATTTATACATATTTGCTAGAGAAATCCAGACTTGTTTCACAACCTCTTGGCCAGAGCAATTTTCTCATTT TCTACTTGTTGATGGATGGGTTATCTGCTGAAGAAAAATATGGACTTCATCTTAATAATTTATGTGCACACCGGTATTTGAACCAGACCA TACAGGATGATGCATCCACAGGGGAGCGTTCTCTGAACAGGGAGAAATTGGCTGTTTTGAAACGAGCCCTGAATGTAGTTGGCTTCAGCA GCTTGGAGGTGGAGAATCTGTTCGTAATTCTAGCAGCAATATTGCACCTTGGAGACATTCGGTTTACTGCCCTGAATGAGGGGAACTCCG CCTTCGTTTCTGACCTCCAGCTCCTGGAACAAGTGGCTGGAATGTTACAAGTATCAACAGATGAATTGGCATCTGCCTTAACAACTGATA TTCAATATTTTAAAGGGGATATGATAATACGACGACATACCATACAGATTGCTGAGTTTTTCCGAGACCTCTTGGCCAAGTCCCTGTACA GTCGTTTGTTTAGCTTTTTGGTGAATACCATGAATTCTTGCCTCCACAGTCAAGATGAACAGAAAAGCATGCAGACATTGGATATTGGAA TATTGGACATTTTTGGTTTTGAAGAGTTTCAAAAGAATGAATTTGAACAACTTTGTGTCAACATGACCAATGAGAAGATGCACCACTATA TCAATGAAGTGCTTTTTCTCCACGAGCAAGTGGAATGTGTACAAGAGGGAGTTACCATGGAAACAGCATATTCTCCTGGTAACCAGAATG GAGTTTTGGACTTTTTTTTCCAGAAGCCATCTGGATTTCTCACCTTATTGGATGAAGAAAGTCAAATGATTTGGTCAGTGGAATCAAATT TTCCAAAAAAACTACAAAGTCTCCTAGAATCCTCAAACACAAATGCGGTGTACTCCCCCATGAAGGATGGGAATGGGAATGTTGCCCTCA AAGACCACGGTACAGCCTTCACCATCATGCACTACGCAGGAAGGGTAATGTATGATGTTGTTGGGGCGATTGAAAAAAATAAAGACTCCC TTTCACAGAATCTTCTATTTGTAATGAAAACTAGTGAAAATGTCGTGATCAATCATTTGTTCCAGTCGAAATTGTCACAAACAGGATCCC TCGTATCTGCCTATCCTTCCTTTAAATTCCGAGGACATAAGTCTGCCCTGCTCAGTAAGAAAATGACAGCTTCTTCAATTATTGGAGAAA ACAAGAATTATCTAGAACTTAGTAAGTTATTAAAAAAGAAAGGAACTTCTACATTTCTTCAAAGATTGGAACGAGGAGATCCAGTCACCA TAGCATCACAACTCAGGAAATCACTAATGGATATTATTGGAAAACTTCAGAAGTGCACTCCACACTTCATTCATTGCATCAGGCCCAATA ACTCAAAGCTGCCAGATACTTTTGATAATTTTTACGTGTCTGCTCAGCTACAATATATTGGGGTCCTGGAGATGGTGAAGATCTTCCGAT ATGGATACCCTGTTCGCCTTTCCTTCTCGGATTTCCTGTCAAGGTATAAGCCACTGGCTGATACATTCCTGCGTGAGAAGAAGGAACAGT CAGCTGCCGAGCGATGTCGACTTGTTCTCCAGCAGTGTAAATTACAAGGCTGGCAGATGGGAGTCCGAAAAGTGTTTCTAAAATACTGGC ATGCTGACCAACTCAATGATTTGTGCCTACAGTTGCAGAGAAAAATTATAACCTGCCAAAAAGTTATCAGAGGATTTTTAGCACGCCAGC ACCTGCTTCAGAGAATAAGCATCAGACAACAAGAGGTGACTTCTATCAATAGCTTTCTGCAGAACACAGAGGACATGGGGCTGAAAACCT ACGATGCCCTGGTCATTCAGAATGCTTCAGACATTGCCCGGGAAAATGACCGGCTCCGTAGTGAAATGAACGCTCCCTACCATAAAGAGA AGTTAGAGGTCAGGAACATGCAAGAGGAAGGAAGCAAAAGAACCGATGACAAGAGTGGACCCAGGCATTTCCACCCCAGCTCCATGTCAG TCTGCGCGGCCGTGGATGGCCTGGGCCAGTGCCTCGTTGGCCCGTCCATCTGGTCTCCTTCGCTGCACTCGGTGTTCAGCATGGATGACA GCAGCAGCCTCCCGTCTCCACGGAAACAGCCCCCGCCCAAGCCAAAGAGGGACCCCAACACCCGGCTGAGTGCTTCCTATGAGGCTGTGA GCGCCTGCCTCTCCGCGGCCAGGGAAGCGGCCAACGAAGCTCTGGCCCGGCCCAGACCGCACAGCGACGACTACAGCACCATGAAGAAGA TTCCTCCTCGAAAGCCCAAGCGCAGCCCCAACACCAAGCTCAGCGGCTCCTACGAGGAGATATCGGGGTCCCGGCCCGGGGACGCGAGGC CCGCGGGCGCCCCGGGGGCAGCAGCGCGCGTTCTGACCCCCGGGACTCCGCAGTGCGCGCTGCCCCCGGCGGCGCCTCCGGGTGACGAGG ACGACAGCGAGCCTGTGTACATCGAGATGCTGGGGCACGCGGCCAGGCCCGATAGCCCGGACCCCGGGGAGTCCGTGTACGAGGAGATGA AGTGTTGCCTGCCCGACGACGGCGGCCCGGGCGCGGGCTCCTTCCTGCTCCACGGCGCATCGCCGCCCCTGCTCCACCGCGCGCCGGAGG ACGAGGCGGCGGGGCCCCCAGGGGACGCGTGCGACATCCCGCCGCCCTTCCCCAACCTGCTGCCGCACCGGCCGCCCCTGCTGGTGTTCC CCCCGACCCCCGTCACCTGCTCCCCCGCCTCCGACGAGTCGCCCCTGACACCCCTGGAGGTGAAGAAGCTGCCAGTCCTGGAGACCAACC TCAAGTACCCCGTGCAGCCGGAGGGGTCGAGCCCGCTGTCCCCGCAGTACTCCAAGAGCCAGAAGGGCGACGGCGACAGGCCCGCGTCCC CCGGCCTGGCGCTGTTCAACGGGTCCGGCCGAGCCTCCCCGCCGTCCACGCCGCCCCCGCCCCCGCCCCCGCCCGGGCCGCCCCCCGCGC CCTACAGGCCCTGCGCGCACTTGGCCTTCCCGCCGGAGCCCGCCCCGGTGAACGCGGGGAAAGCGGGGCCGAGCGCAGAGGCGCCCAAGG TTCACCCAAAGCCAAACTCTGCCCCCGTGGCCGGGCCCTGCAGCTCCTTCCCCAAGATCCCATATTCCCCCGTGAAGGCCACCAGGGCGG ACGCCAGGAAGGCCGGCTCCAGTGCCTCGCCCCCCGCGCCCTACAGCCCTCCCAGCTCCAGGCCTCTCAGCAGCCCCCTGGACGAGCTCG CCAGCCTCTTCAACTCGGGGAGGAGTGTGCTTCGGAAATCCGCGGCGGGAAGAAAAATCAGGGAAGCAGAAGGTTTTGAAACTAACATGA ACATAAGTAGCCGAGATGACCCTAGTACGTCAGAAATTACTTCCGAGACTCAAGACAGAAATGCAAATAACCATGGAATTCAGTTATCTA ATTCACTATCTAGTGCTATAACTGCTGAAAATGGAAATTCCATCTCAAATGGTTTACCTGAAGAAGATGGATACTCACGGTTGTCTATAA GTGGCACAGGGACTTCGACATTTCAAAGACACAGGGACAGTCACACCACTCAGGTAATCCATCAGCTGAGGCTCTCAGAGAATGAAAGTG TGGCCCTGCAGGAACTCTTGGACTGGAGGAGAAAGCTCTGTGAGGAAGGACAAGACTGGCAGCAGATCCTGCACCACGCTGAGCCCAGGG TGCCTCCCCCACCACCTTGCAAGAAGCCCAGCCTTCTGAAGAAGCCGGAAGGGGCCTCCTGCAACAGGCTGCCGTCTGAGCTCTGGGACA CCACCATTTGATGTGGCCTGAACTGCAGACTTACAAAATAGAACTGCCTACTGATTCCGGGCTGCAACAACAGAAGGCTGCCTTCTGACA TGCGCTGGGGCTTCTCTCCACGCATTTAGACAAAAAAAGCACAGGACACAGACACTAAATATATGAGATCCCGTGTGTGTGTGTGTGTGT TTGTGTGTGTGTGTGTGGGTTCTTTCTTATCCATCTCGTGGTGATACACTCTGATTTTCAAGCTCCTCATTTACGGCTCTGTGCTACCCC TAGGTAGCAAGAGAGAGGCTGGGAAAAGTGTGGACGTGGCCAGAGCGAGAGAGTAGCGGAGGAAAGGAGCAATCCATGCACACTCTGTAC AGTTGTTTTTCTACGGTTCAACAGTCTGTTTATTGTACTTCCAATGGTTTTATTATAATACAGTATACGGGACATATATTTTATTTCTTT GTAGCTACTTGTGTTTTATTGGTATTATAAACCTGATAATTATTTACATGTTTATTACTGTAATTTTATAAATTTATGCAATTGGTGGTG CTTCCTTTCTTCAAAATACAGATTTTAAAAAATCATTTCTAGATTATTTTTTTCCTCCACAGTCCTTTTTTTTCACCTAACGCACCTAAA TCTTGAAACTACATTGTTGTTTTAGCTTCGCCAGTGTCACCCCTTGCAAAACTATGAATTGAGCCCCATGTTTTAGGTGTTACTCATGGA TGAGGAGGCTGTTCTTTCCTATGCCCTGTATTTCTGGATAAGTGGATTGTGTACCCTTTAGTTAAATTTCACCTCCCGACTTCAGCATAG ATCACAGGAAATCACATGGCACACGGTTAAACACGTATGGCTTCAAATCCATAGCCGGTGGTGTAAAATGATCATATTCATTCAAAGGCC TACACAGTACAAATGAGCACGCTGCCATGTACTGGTTTGAGCAGTAGGGGCTGCATCGCACAGCGCTCGTCCCCCGGGACTTACACTGCA TGATTCCCTCACTGTATATCCTCAACCCTCCCATAATGCAAGGCCTTGTTCATTGATGTGCTTTCGTCGGCTGTCGGAAAGTTCTGAGCA >30845_30845_3_FN3K-MYO16_FN3K_chr17_80706853_ENST00000300784_MYO16_chr13_109535407_ENST00000357550_length(amino acids)=1602AA_BP=196 MEQLLRAELRTATLRAFGGPGAGCISEGRAYDTDAGPVFVKVNRRTQARQMFEGEVASLEALRSTGLVRVPRPMKVIDLPGGGAAFVMEH LKMKSLSSQASKLGEQMADLHLYNQKLREKLKEEENTVGRRGEGAEPQYVDKFGFHTVTCCGFIPQVNEWQDDWPTFFARHRLQAQLDLI EKDYADREARELWSRLQVSQLYFSSSGKLCSSLPPHLFSCVERAFHQLFREQRPQCFILSGERGSGKSEASKQIIRHLTCRAGASRATLD SRFKHVVCILEAFGHAKTTLNDLSSCFIKYFELQFCERKQQLTGARIYTYLLEKSRLVSQPLGQSNFLIFYLLMDGLSAEEKYGLHLNNL CAHRYLNQTIQDDASTGERSLNREKLAVLKRALNVVGFSSLEVENLFVILAAILHLGDIRFTALNEGNSAFVSDLQLLEQVAGMLQVSTD ELASALTTDIQYFKGDMIIRRHTIQIAEFFRDLLAKSLYSRLFSFLVNTMNSCLHSQDEQKSMQTLDIGILDIFGFEEFQKNEFEQLCVN MTNEKMHHYINEVLFLHEQVECVQEGVTMETAYSPGNQNGVLDFFFQKPSGFLTLLDEESQMIWSVESNFPKKLQSLLESSNTNAVYSPM KDGNGNVALKDHGTAFTIMHYAGRVMYDVVGAIEKNKDSLSQNLLFVMKTSENVVINHLFQSKLSQTGSLVSAYPSFKFRGHKSALLSKK MTASSIIGENKNYLELSKLLKKKGTSTFLQRLERGDPVTIASQLRKSLMDIIGKLQKCTPHFIHCIRPNNSKLPDTFDNFYVSAQLQYIG VLEMVKIFRYGYPVRLSFSDFLSRYKPLADTFLREKKEQSAAERCRLVLQQCKLQGWQMGVRKVFLKYWHADQLNDLCLQLQRKIITCQK VIRGFLARQHLLQRISIRQQEVTSINSFLQNTEDMGLKTYDALVIQNASDIARENDRLRSEMNAPYHKEKLEVRNMQEEGSKRTDDKSGP RHFHPSSMSVCAAVDGLGQCLVGPSIWSPSLHSVFSMDDSSSLPSPRKQPPPKPKRDPNTRLSASYEAVSACLSAAREAANEALARPRPH SDDYSTMKKIPPRKPKRSPNTKLSGSYEEISGSRPGDARPAGAPGAAARVLTPGTPQCALPPAAPPGDEDDSEPVYIEMLGHAARPDSPD PGESVYEEMKCCLPDDGGPGAGSFLLHGASPPLLHRAPEDEAAGPPGDACDIPPPFPNLLPHRPPLLVFPPTPVTCSPASDESPLTPLEV KKLPVLETNLKYPVQPEGSSPLSPQYSKSQKGDGDRPASPGLALFNGSGRASPPSTPPPPPPPPGPPPAPYRPCAHLAFPPEPAPVNAGK AGPSAEAPKVHPKPNSAPVAGPCSSFPKIPYSPVKATRADARKAGSSASPPAPYSPPSSRPLSSPLDELASLFNSGRSVLRKSAAGRKIR EAEGFETNMNISSRDDPSTSEITSETQDRNANNHGIQLSNSLSSAITAENGNSISNGLPEEDGYSRLSISGTGTSTFQRHRDSHTTQVIH -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for FN3K-MYO16 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for FN3K-MYO16 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for FN3K-MYO16 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | C0036341 | Schizophrenia | 1 | PSYGENET |
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