Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ATL2-DHX57 (FusionGDB2 ID:HG64225TG90957)

Fusion Gene Summary for ATL2-DHX57

check button Fusion gene summary
Fusion gene informationFusion gene name: ATL2-DHX57
Fusion gene ID: hg64225tg90957
HgeneTgene
Gene symbol

ATL2

DHX57

Gene ID

64225

90957

Gene nameatlastin GTPase 2DExH-box helicase 57
SynonymsARL3IP2|ARL6IP2|aip-2|atlastin2DDX57
Cytomap('ATL2')('DHX57')

2p22.2-p22.1

2p22.1

Type of geneprotein-codingprotein-coding
Descriptionatlastin-2ADP-ribosylation factor-like protein 6-interacting protein 2ARL-6-interacting protein 2putative ATP-dependent RNA helicase DHX57DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57DEAH box protein 57DEAH-box RNA/DNA helicase AAM73547DEAH-box helicase 57
Modification date2020031320200320
UniProtAcc.

Q6P158

Ensembl transtripts involved in fusion geneENST00000332337, ENST00000378954, 
ENST00000419554, ENST00000452935, 
ENST00000406122, ENST00000539122, 
ENST00000402054, ENST00000486927, 
ENST00000546051, 
Fusion gene scores* DoF score14 X 10 X 5=7006 X 8 X 5=240
# samples 168
** MAII scorelog2(16/700*10)=-2.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/240*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATL2 [Title/Abstract] AND DHX57 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATL2(38604285)-DHX57(39030057), # samples:2
Anticipated loss of major functional domain due to fusion event.ATL2-DHX57 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATL2-DHX57 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATL2-DHX57 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATL2

GO:0051260

protein homooligomerization

18270207


check buttonFusion gene breakpoints across ATL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across DHX57 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A14N-01AATL2chr2

38604285

-DHX57chr2

39030057

-
ChimerDB4BRCATCGA-GI-A2C9-01AATL2chr2

38604285

-DHX57chr2

39075544

-
ChimerDB4STADTCGA-CD-8530-01AATL2chr2

38570410

-DHX57chr2

39095553

-


Top

Fusion Gene ORF analysis for ATL2-DHX57

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000332337ENST00000295373ATL2chr2

38570410

-DHX57chr2

39095553

-
5CDS-5UTRENST00000378954ENST00000295373ATL2chr2

38570410

-DHX57chr2

39095553

-
5CDS-5UTRENST00000419554ENST00000295373ATL2chr2

38570410

-DHX57chr2

39095553

-
5CDS-5UTRENST00000452935ENST00000295373ATL2chr2

38570410

-DHX57chr2

39095553

-
5CDS-intronENST00000332337ENST00000479345ATL2chr2

38570410

-DHX57chr2

39095553

-
5CDS-intronENST00000378954ENST00000479345ATL2chr2

38604285

-DHX57chr2

39030057

-
5CDS-intronENST00000378954ENST00000479345ATL2chr2

38604285

-DHX57chr2

39075544

-
5CDS-intronENST00000378954ENST00000479345ATL2chr2

38570410

-DHX57chr2

39095553

-
5CDS-intronENST00000419554ENST00000479345ATL2chr2

38604285

-DHX57chr2

39030057

-
5CDS-intronENST00000419554ENST00000479345ATL2chr2

38604285

-DHX57chr2

39075544

-
5CDS-intronENST00000419554ENST00000479345ATL2chr2

38570410

-DHX57chr2

39095553

-
5CDS-intronENST00000452935ENST00000479345ATL2chr2

38570410

-DHX57chr2

39095553

-
5UTR-3CDSENST00000406122ENST00000295373ATL2chr2

38604285

-DHX57chr2

39030057

-
5UTR-3CDSENST00000406122ENST00000295373ATL2chr2

38604285

-DHX57chr2

39075544

-
5UTR-3CDSENST00000539122ENST00000295373ATL2chr2

38604285

-DHX57chr2

39030057

-
5UTR-3CDSENST00000539122ENST00000295373ATL2chr2

38604285

-DHX57chr2

39075544

-
5UTR-intronENST00000406122ENST00000479345ATL2chr2

38604285

-DHX57chr2

39030057

-
5UTR-intronENST00000406122ENST00000479345ATL2chr2

38604285

-DHX57chr2

39075544

-
5UTR-intronENST00000539122ENST00000479345ATL2chr2

38604285

-DHX57chr2

39030057

-
5UTR-intronENST00000539122ENST00000479345ATL2chr2

38604285

-DHX57chr2

39075544

-
Frame-shiftENST00000378954ENST00000295373ATL2chr2

38604285

-DHX57chr2

39075544

-
Frame-shiftENST00000419554ENST00000295373ATL2chr2

38604285

-DHX57chr2

39075544

-
In-frameENST00000378954ENST00000295373ATL2chr2

38604285

-DHX57chr2

39030057

-
In-frameENST00000419554ENST00000295373ATL2chr2

38604285

-DHX57chr2

39030057

-
intron-3CDSENST00000332337ENST00000295373ATL2chr2

38604285

-DHX57chr2

39030057

-
intron-3CDSENST00000332337ENST00000295373ATL2chr2

38604285

-DHX57chr2

39075544

-
intron-3CDSENST00000402054ENST00000295373ATL2chr2

38604285

-DHX57chr2

39030057

-
intron-3CDSENST00000402054ENST00000295373ATL2chr2

38604285

-DHX57chr2

39075544

-
intron-3CDSENST00000452935ENST00000295373ATL2chr2

38604285

-DHX57chr2

39030057

-
intron-3CDSENST00000452935ENST00000295373ATL2chr2

38604285

-DHX57chr2

39075544

-
intron-3CDSENST00000486927ENST00000295373ATL2chr2

38604285

-DHX57chr2

39030057

-
intron-3CDSENST00000486927ENST00000295373ATL2chr2

38604285

-DHX57chr2

39075544

-
intron-3CDSENST00000546051ENST00000295373ATL2chr2

38604285

-DHX57chr2

39030057

-
intron-3CDSENST00000546051ENST00000295373ATL2chr2

38604285

-DHX57chr2

39075544

-
intron-5UTRENST00000402054ENST00000295373ATL2chr2

38570410

-DHX57chr2

39095553

-
intron-5UTRENST00000406122ENST00000295373ATL2chr2

38570410

-DHX57chr2

39095553

-
intron-5UTRENST00000486927ENST00000295373ATL2chr2

38570410

-DHX57chr2

39095553

-
intron-5UTRENST00000539122ENST00000295373ATL2chr2

38570410

-DHX57chr2

39095553

-
intron-5UTRENST00000546051ENST00000295373ATL2chr2

38570410

-DHX57chr2

39095553

-
intron-intronENST00000332337ENST00000479345ATL2chr2

38604285

-DHX57chr2

39030057

-
intron-intronENST00000332337ENST00000479345ATL2chr2

38604285

-DHX57chr2

39075544

-
intron-intronENST00000402054ENST00000479345ATL2chr2

38604285

-DHX57chr2

39030057

-
intron-intronENST00000402054ENST00000479345ATL2chr2

38604285

-DHX57chr2

39075544

-
intron-intronENST00000402054ENST00000479345ATL2chr2

38570410

-DHX57chr2

39095553

-
intron-intronENST00000406122ENST00000479345ATL2chr2

38570410

-DHX57chr2

39095553

-
intron-intronENST00000452935ENST00000479345ATL2chr2

38604285

-DHX57chr2

39030057

-
intron-intronENST00000452935ENST00000479345ATL2chr2

38604285

-DHX57chr2

39075544

-
intron-intronENST00000486927ENST00000479345ATL2chr2

38604285

-DHX57chr2

39030057

-
intron-intronENST00000486927ENST00000479345ATL2chr2

38604285

-DHX57chr2

39075544

-
intron-intronENST00000486927ENST00000479345ATL2chr2

38570410

-DHX57chr2

39095553

-
intron-intronENST00000539122ENST00000479345ATL2chr2

38570410

-DHX57chr2

39095553

-
intron-intronENST00000546051ENST00000479345ATL2chr2

38604285

-DHX57chr2

39030057

-
intron-intronENST00000546051ENST00000479345ATL2chr2

38604285

-DHX57chr2

39075544

-
intron-intronENST00000546051ENST00000479345ATL2chr2

38570410

-DHX57chr2

39095553

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000378954ATL2chr238604285-ENST00000295373DHX57chr239030057-103512046190123
ENST00000419554ATL2chr238604285-ENST00000295373DHX57chr239030057-1046131472101123

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000378954ENST00000295373ATL2chr238604285-DHX57chr239030057-0.434377370.5656226
ENST00000419554ENST00000295373ATL2chr238604285-DHX57chr239030057-0.45944920.5405508

Top

Fusion Genomic Features for ATL2-DHX57


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

Top

Fusion Protein Features for ATL2-DHX57


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:38604285/chr2:39030057)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DHX57

Q6P158

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Probable ATP-binding RNA helicase.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATL2chr2:38604285chr2:39030057ENST00000332337-114256_2840567.0Coiled coilOntology_term=ECO:0000255
HgeneATL2chr2:38604285chr2:39030057ENST00000378954-113256_28439584.0Coiled coilOntology_term=ECO:0000255
HgeneATL2chr2:38604285chr2:39030057ENST00000402054-112256_2840413.0Coiled coilOntology_term=ECO:0000255
HgeneATL2chr2:38604285chr2:39030057ENST00000419554-113256_28439580.0Coiled coilOntology_term=ECO:0000255
HgeneATL2chr2:38604285chr2:39030057ENST00000539122-112256_2840413.0Coiled coilOntology_term=ECO:0000255
HgeneATL2chr2:38604285chr2:39030057ENST00000332337-11491_3360567.0DomainGB1/RHD3-type G
HgeneATL2chr2:38604285chr2:39030057ENST00000378954-11391_33639584.0DomainGB1/RHD3-type G
HgeneATL2chr2:38604285chr2:39030057ENST00000402054-11291_3360413.0DomainGB1/RHD3-type G
HgeneATL2chr2:38604285chr2:39030057ENST00000419554-11391_33639580.0DomainGB1/RHD3-type G
HgeneATL2chr2:38604285chr2:39030057ENST00000539122-11291_3360413.0DomainGB1/RHD3-type G
HgeneATL2chr2:38604285chr2:39030057ENST00000332337-114101_1080567.0Nucleotide bindingGTP
HgeneATL2chr2:38604285chr2:39030057ENST00000332337-114145_1470567.0Nucleotide bindingGTP
HgeneATL2chr2:38604285chr2:39030057ENST00000332337-114244_2450567.0Nucleotide bindingGTP
HgeneATL2chr2:38604285chr2:39030057ENST00000332337-114303_3060567.0Nucleotide bindingGTP
HgeneATL2chr2:38604285chr2:39030057ENST00000378954-113101_10839584.0Nucleotide bindingGTP
HgeneATL2chr2:38604285chr2:39030057ENST00000378954-113145_14739584.0Nucleotide bindingGTP
HgeneATL2chr2:38604285chr2:39030057ENST00000378954-113244_24539584.0Nucleotide bindingGTP
HgeneATL2chr2:38604285chr2:39030057ENST00000378954-113303_30639584.0Nucleotide bindingGTP
HgeneATL2chr2:38604285chr2:39030057ENST00000402054-112101_1080413.0Nucleotide bindingGTP
HgeneATL2chr2:38604285chr2:39030057ENST00000402054-112145_1470413.0Nucleotide bindingGTP
HgeneATL2chr2:38604285chr2:39030057ENST00000402054-112244_2450413.0Nucleotide bindingGTP
HgeneATL2chr2:38604285chr2:39030057ENST00000402054-112303_3060413.0Nucleotide bindingGTP
HgeneATL2chr2:38604285chr2:39030057ENST00000419554-113101_10839580.0Nucleotide bindingGTP
HgeneATL2chr2:38604285chr2:39030057ENST00000419554-113145_14739580.0Nucleotide bindingGTP
HgeneATL2chr2:38604285chr2:39030057ENST00000419554-113244_24539580.0Nucleotide bindingGTP
HgeneATL2chr2:38604285chr2:39030057ENST00000419554-113303_30639580.0Nucleotide bindingGTP
HgeneATL2chr2:38604285chr2:39030057ENST00000539122-112101_1080413.0Nucleotide bindingGTP
HgeneATL2chr2:38604285chr2:39030057ENST00000539122-112145_1470413.0Nucleotide bindingGTP
HgeneATL2chr2:38604285chr2:39030057ENST00000539122-112244_2450413.0Nucleotide bindingGTP
HgeneATL2chr2:38604285chr2:39030057ENST00000539122-112303_3060413.0Nucleotide bindingGTP
HgeneATL2chr2:38604285chr2:39030057ENST00000332337-1141_4760567.0Topological domainCytoplasmic
HgeneATL2chr2:38604285chr2:39030057ENST00000332337-114498_4990567.0Topological domainLumenal
HgeneATL2chr2:38604285chr2:39030057ENST00000332337-114521_5830567.0Topological domainCytoplasmic
HgeneATL2chr2:38604285chr2:39030057ENST00000378954-1131_47639584.0Topological domainCytoplasmic
HgeneATL2chr2:38604285chr2:39030057ENST00000378954-113498_49939584.0Topological domainLumenal
HgeneATL2chr2:38604285chr2:39030057ENST00000378954-113521_58339584.0Topological domainCytoplasmic
HgeneATL2chr2:38604285chr2:39030057ENST00000402054-1121_4760413.0Topological domainCytoplasmic
HgeneATL2chr2:38604285chr2:39030057ENST00000402054-112498_4990413.0Topological domainLumenal
HgeneATL2chr2:38604285chr2:39030057ENST00000402054-112521_5830413.0Topological domainCytoplasmic
HgeneATL2chr2:38604285chr2:39030057ENST00000419554-1131_47639580.0Topological domainCytoplasmic
HgeneATL2chr2:38604285chr2:39030057ENST00000419554-113498_49939580.0Topological domainLumenal
HgeneATL2chr2:38604285chr2:39030057ENST00000419554-113521_58339580.0Topological domainCytoplasmic
HgeneATL2chr2:38604285chr2:39030057ENST00000539122-1121_4760413.0Topological domainCytoplasmic
HgeneATL2chr2:38604285chr2:39030057ENST00000539122-112498_4990413.0Topological domainLumenal
HgeneATL2chr2:38604285chr2:39030057ENST00000539122-112521_5830413.0Topological domainCytoplasmic
HgeneATL2chr2:38604285chr2:39030057ENST00000332337-114477_4970567.0TransmembraneHelical
HgeneATL2chr2:38604285chr2:39030057ENST00000332337-114500_5200567.0TransmembraneHelical
HgeneATL2chr2:38604285chr2:39030057ENST00000378954-113477_49739584.0TransmembraneHelical
HgeneATL2chr2:38604285chr2:39030057ENST00000378954-113500_52039584.0TransmembraneHelical
HgeneATL2chr2:38604285chr2:39030057ENST00000402054-112477_4970413.0TransmembraneHelical
HgeneATL2chr2:38604285chr2:39030057ENST00000402054-112500_5200413.0TransmembraneHelical
HgeneATL2chr2:38604285chr2:39030057ENST00000419554-113477_49739580.0TransmembraneHelical
HgeneATL2chr2:38604285chr2:39030057ENST00000419554-113500_52039580.0TransmembraneHelical
HgeneATL2chr2:38604285chr2:39030057ENST00000539122-112477_4970413.0TransmembraneHelical
HgeneATL2chr2:38604285chr2:39030057ENST00000539122-112500_5200413.0TransmembraneHelical
TgeneDHX57chr2:38604285chr2:39030057ENST000002953732124101_12512721387.0Coiled coilOntology_term=ECO:0000255
TgeneDHX57chr2:38604285chr2:39030057ENST0000029537321249_4912721387.0Compositional biasNote=Gly-rich
TgeneDHX57chr2:38604285chr2:39030057ENST000002953732124180_22012721387.0DomainUBA
TgeneDHX57chr2:38604285chr2:39030057ENST000002953732124554_72112721387.0DomainHelicase ATP-binding
TgeneDHX57chr2:38604285chr2:39030057ENST000002953732124830_101012721387.0DomainHelicase C-terminal
TgeneDHX57chr2:38604285chr2:39030057ENST000002953732124668_67112721387.0MotifNote=DEVH box
TgeneDHX57chr2:38604285chr2:39030057ENST000002953732124567_57412721387.0Nucleotide bindingATP
TgeneDHX57chr2:38604285chr2:39030057ENST000002953732124299_32612721387.0Zinc fingerC3H1-type


Top

Fusion Gene Sequence for ATL2-DHX57


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7644_7644_1_ATL2-DHX57_ATL2_chr2_38604285_ENST00000378954_DHX57_chr2_39030057_ENST00000295373_length(transcript)=1035nt_BP=120nt
AGATGGCGGAGGGGGACGAGGCAGCGCGAGGGCAGCAACCGCACCAGGGGCTGTGGCGCCGGCGACGGACCAGCGACCCAAGCGCCGCGG
TTAACCACGTCTCGTCCACGACCTCCCTAGGTGAGACACTTTGACAGCCCCTACCTGTTGTACCACGAGAAGATAAAAACTAGTCGAGTA
TTCATCCGAGACTGCAGCATGGTGTCTGTGTACCCGCTGGTCTTGTTTGGAGGAGGCCAAGTGAATGTGCAGCTTCAAAGAGGAGAGTTC
GTTGTCTCCCTGGATGATGGTTGGATCCGTTTTGTAGCTGCTTCCCATCAGGTGGCTGAACTGGTAAAGGAGCTTCGTTGCGAACTTGAT
CAGCTTCTCCAGGATAAAATTAAAAACCCAAGCATTGATCTGTGTACGTGTCCTCGAGGATCCCGGATCATCAGCACAATTGTGAAACTT
GTCACCACACAATAAAAAGCAGTCTTAGAGAGTGCTTGCTACTCACCTGCTTCTAGCTCACCTGGGAAATAACAGCAGAACCTCTACCTC
GAACTAAAGACCTATTGGGGCTGGCCCTGGTGGAGGAGCCCAGGGCATGAAGCCCAAGGCAGCTGAGGCAGTGTATATACCCTTAGGGCC
ATTTCTAACAAAGCCTTGGCCACTCCCAGCACAATTTGGAGTGTCAAGGGTGAGAGCCTAAAACCCAGCTTGCCTGTCTTTGTCTCTGTG
ATTGTTCTGGAGTGAATTAAGTTCACCTGATAACTCAAAAGTGAATGTATAATACAATTCTGTTTTAATCTGTGTATTCTTTTTCTCCTA
CTTTTTACTGGGGTGAGAGGGGCATGAAGAGAAATACGCCTTTTTTTTTTTTCTTTTCCTGTCGCCAAGGCTCGACTGAGAGAAGTCAGA
ACAGAGAAGGGGAAAAAAAACCCAAAATTATGTGAACAAGCAAAATTAAAATTTCATTTTAGGCTATTGGCTACTGAGTAAACTTGACTT
GTGAGGGGTTTTTATTTTTACTCATTAAAAGTCAACTTAAAAAAA

>7644_7644_1_ATL2-DHX57_ATL2_chr2_38604285_ENST00000378954_DHX57_chr2_39030057_ENST00000295373_length(amino acids)=123AA_BP=1
MCGDKFHNCADDPGSSRTRTQINAWVFNFILEKLIKFATKLLYQFSHLMGSSYKTDPTIIQGDNELSSLKLHIHLASSKQDQRVHRHHAA
VSDEYSTSFYLLVVQQVGAVKVSHLGRSWTRRG

--------------------------------------------------------------
>7644_7644_2_ATL2-DHX57_ATL2_chr2_38604285_ENST00000419554_DHX57_chr2_39030057_ENST00000295373_length(transcript)=1046nt_BP=131nt
AAATCGGTACAAGATGGCGGAGGGGGACGAGGCAGCGCGAGGGCAGCAACCGCACCAGGGGCTGTGGCGCCGGCGACGGACCAGCGACCC
AAGCGCCGCGGTTAACCACGTCTCGTCCACGACCTCCCTAGGTGAGACACTTTGACAGCCCCTACCTGTTGTACCACGAGAAGATAAAAA
CTAGTCGAGTATTCATCCGAGACTGCAGCATGGTGTCTGTGTACCCGCTGGTCTTGTTTGGAGGAGGCCAAGTGAATGTGCAGCTTCAAA
GAGGAGAGTTCGTTGTCTCCCTGGATGATGGTTGGATCCGTTTTGTAGCTGCTTCCCATCAGGTGGCTGAACTGGTAAAGGAGCTTCGTT
GCGAACTTGATCAGCTTCTCCAGGATAAAATTAAAAACCCAAGCATTGATCTGTGTACGTGTCCTCGAGGATCCCGGATCATCAGCACAA
TTGTGAAACTTGTCACCACACAATAAAAAGCAGTCTTAGAGAGTGCTTGCTACTCACCTGCTTCTAGCTCACCTGGGAAATAACAGCAGA
ACCTCTACCTCGAACTAAAGACCTATTGGGGCTGGCCCTGGTGGAGGAGCCCAGGGCATGAAGCCCAAGGCAGCTGAGGCAGTGTATATA
CCCTTAGGGCCATTTCTAACAAAGCCTTGGCCACTCCCAGCACAATTTGGAGTGTCAAGGGTGAGAGCCTAAAACCCAGCTTGCCTGTCT
TTGTCTCTGTGATTGTTCTGGAGTGAATTAAGTTCACCTGATAACTCAAAAGTGAATGTATAATACAATTCTGTTTTAATCTGTGTATTC
TTTTTCTCCTACTTTTTACTGGGGTGAGAGGGGCATGAAGAGAAATACGCCTTTTTTTTTTTTCTTTTCCTGTCGCCAAGGCTCGACTGA
GAGAAGTCAGAACAGAGAAGGGGAAAAAAAACCCAAAATTATGTGAACAAGCAAAATTAAAATTTCATTTTAGGCTATTGGCTACTGAGT
AAACTTGACTTGTGAGGGGTTTTTATTTTTACTCATTAAAAGTCAACTTAAAAAAA

>7644_7644_2_ATL2-DHX57_ATL2_chr2_38604285_ENST00000419554_DHX57_chr2_39030057_ENST00000295373_length(amino acids)=123AA_BP=1
MCGDKFHNCADDPGSSRTRTQINAWVFNFILEKLIKFATKLLYQFSHLMGSSYKTDPTIIQGDNELSSLKLHIHLASSKQDQRVHRHHAA
VSDEYSTSFYLLVVQQVGAVKVSHLGRSWTRRG

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ATL2-DHX57


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ATL2-DHX57


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ATL2-DHX57


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource