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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RGNEF-SEZ6 (FusionGDB2 ID:HG64283TG124925)

Fusion Gene Summary for RGNEF-SEZ6

check button Fusion gene summary
Fusion gene informationFusion gene name: RGNEF-SEZ6
Fusion gene ID: hg64283tg124925
HgeneTgene
Gene symbol

RGNEF

SEZ6

Gene ID

64283

124925

Gene nameRho guanine nucleotide exchange factor 28seizure related 6 homolog
SynonymsRGNEF|RIP2|p190RHOGEFBSRPC
Cytomap('ARHGEF28','RGNEF')('SEZ6','SEZ6')

5q13.2

17q11.2

Type of geneprotein-codingprotein-coding
Descriptionrho guanine nucleotide exchange factor 28190 kDa guanine nucleotide exchange factorRho guanine nucleotide exchange factor (GEF) 28Rho interacting protein 2p190-RhoGEFrho-guanine nucleotide exchange factorseizure protein 6 homolog
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000287898, ENST00000296794, 
ENST00000426542, ENST00000437974, 
ENST00000513042, ENST00000545377, 
ENST00000296799, ENST00000512883, 
ENST00000513841, 
Fusion gene scores* DoF score6 X 5 X 3=907 X 3 X 4=84
# samples 610
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/84*10)=0.251538766995964
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RGNEF [Title/Abstract] AND SEZ6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGEF28(72980709)-SEZ6(27296970), # samples:2
RGNEF(72980709)-SEZ6(27296970), # samples:1
Anticipated loss of major functional domain due to fusion event.ARHGEF28-SEZ6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGEF28-SEZ6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGEF28-SEZ6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGEF28-SEZ6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ARHGEF28 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SEZ6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-1471-01AARHGEF28chr5

72980709

+SEZ6chr17

27296970

-
ChimerDB4OVTCGA-24-1471RGNEFchr5

72980709

+SEZ6chr17

27296970

-


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Fusion Gene ORF analysis for RGNEF-SEZ6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000287898ENST00000317338ARHGEF28chr5

72980709

+SEZ6chr17

27296970

-
In-frameENST00000287898ENST00000335960ARHGEF28chr5

72980709

+SEZ6chr17

27296970

-
In-frameENST00000287898ENST00000360295ARHGEF28chr5

72980709

+SEZ6chr17

27296970

-
In-frameENST00000287898ENST00000442608ARHGEF28chr5

72980709

+SEZ6chr17

27296970

-
In-frameENST00000296794ENST00000317338ARHGEF28chr5

72980709

+SEZ6chr17

27296970

-
In-frameENST00000296794ENST00000335960ARHGEF28chr5

72980709

+SEZ6chr17

27296970

-
In-frameENST00000296794ENST00000360295ARHGEF28chr5

72980709

+SEZ6chr17

27296970

-
In-frameENST00000296794ENST00000442608ARHGEF28chr5

72980709

+SEZ6chr17

27296970

-
In-frameENST00000426542ENST00000317338ARHGEF28chr5

72980709

+SEZ6chr17

27296970

-
In-frameENST00000426542ENST00000335960ARHGEF28chr5

72980709

+SEZ6chr17

27296970

-
In-frameENST00000426542ENST00000360295ARHGEF28chr5

72980709

+SEZ6chr17

27296970

-
In-frameENST00000426542ENST00000442608ARHGEF28chr5

72980709

+SEZ6chr17

27296970

-
In-frameENST00000437974ENST00000317338ARHGEF28chr5

72980709

+SEZ6chr17

27296970

-
In-frameENST00000437974ENST00000335960ARHGEF28chr5

72980709

+SEZ6chr17

27296970

-
In-frameENST00000437974ENST00000360295ARHGEF28chr5

72980709

+SEZ6chr17

27296970

-
In-frameENST00000437974ENST00000442608ARHGEF28chr5

72980709

+SEZ6chr17

27296970

-
In-frameENST00000513042ENST00000317338ARHGEF28chr5

72980709

+SEZ6chr17

27296970

-
In-frameENST00000513042ENST00000335960ARHGEF28chr5

72980709

+SEZ6chr17

27296970

-
In-frameENST00000513042ENST00000360295ARHGEF28chr5

72980709

+SEZ6chr17

27296970

-
In-frameENST00000513042ENST00000442608ARHGEF28chr5

72980709

+SEZ6chr17

27296970

-
In-frameENST00000545377ENST00000317338ARHGEF28chr5

72980709

+SEZ6chr17

27296970

-
In-frameENST00000545377ENST00000335960ARHGEF28chr5

72980709

+SEZ6chr17

27296970

-
In-frameENST00000545377ENST00000360295ARHGEF28chr5

72980709

+SEZ6chr17

27296970

-
In-frameENST00000545377ENST00000442608ARHGEF28chr5

72980709

+SEZ6chr17

27296970

-
intron-3CDSENST00000296799ENST00000317338ARHGEF28chr5

72980709

+SEZ6chr17

27296970

-
intron-3CDSENST00000296799ENST00000335960ARHGEF28chr5

72980709

+SEZ6chr17

27296970

-
intron-3CDSENST00000296799ENST00000360295ARHGEF28chr5

72980709

+SEZ6chr17

27296970

-
intron-3CDSENST00000296799ENST00000442608ARHGEF28chr5

72980709

+SEZ6chr17

27296970

-
intron-3CDSENST00000512883ENST00000317338ARHGEF28chr5

72980709

+SEZ6chr17

27296970

-
intron-3CDSENST00000512883ENST00000335960ARHGEF28chr5

72980709

+SEZ6chr17

27296970

-
intron-3CDSENST00000512883ENST00000360295ARHGEF28chr5

72980709

+SEZ6chr17

27296970

-
intron-3CDSENST00000512883ENST00000442608ARHGEF28chr5

72980709

+SEZ6chr17

27296970

-
intron-3CDSENST00000513841ENST00000317338ARHGEF28chr5

72980709

+SEZ6chr17

27296970

-
intron-3CDSENST00000513841ENST00000335960ARHGEF28chr5

72980709

+SEZ6chr17

27296970

-
intron-3CDSENST00000513841ENST00000360295ARHGEF28chr5

72980709

+SEZ6chr17

27296970

-
intron-3CDSENST00000513841ENST00000442608ARHGEF28chr5

72980709

+SEZ6chr17

27296970

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000296794ARHGEF28chr572980709+ENST00000360295SEZ6chr1727296970-338120952332775
ENST00000296794ARHGEF28chr572980709+ENST00000317338SEZ6chr1727296970-339320952335776
ENST00000296794ARHGEF28chr572980709+ENST00000442608SEZ6chr1727296970-311220952293762
ENST00000296794ARHGEF28chr572980709+ENST00000335960SEZ6chr1727296970-8782095877291
ENST00000287898ARHGEF28chr572980709+ENST00000360295SEZ6chr1727296970-338120952332775
ENST00000287898ARHGEF28chr572980709+ENST00000317338SEZ6chr1727296970-339320952335776
ENST00000287898ARHGEF28chr572980709+ENST00000442608SEZ6chr1727296970-311220952293762
ENST00000287898ARHGEF28chr572980709+ENST00000335960SEZ6chr1727296970-8782095877291
ENST00000545377ARHGEF28chr572980709+ENST00000360295SEZ6chr1727296970-338120952332775
ENST00000545377ARHGEF28chr572980709+ENST00000317338SEZ6chr1727296970-339320952335776
ENST00000545377ARHGEF28chr572980709+ENST00000442608SEZ6chr1727296970-311220952293762
ENST00000545377ARHGEF28chr572980709+ENST00000335960SEZ6chr1727296970-8782095877291
ENST00000513042ARHGEF28chr572980709+ENST00000360295SEZ6chr1727296970-338120952332775
ENST00000513042ARHGEF28chr572980709+ENST00000317338SEZ6chr1727296970-339320952335776
ENST00000513042ARHGEF28chr572980709+ENST00000442608SEZ6chr1727296970-311220952293762
ENST00000513042ARHGEF28chr572980709+ENST00000335960SEZ6chr1727296970-8782095877291
ENST00000437974ARHGEF28chr572980709+ENST00000360295SEZ6chr1727296970-322553202176718
ENST00000437974ARHGEF28chr572980709+ENST00000317338SEZ6chr1727296970-323753202179719
ENST00000437974ARHGEF28chr572980709+ENST00000442608SEZ6chr1727296970-295653202137705
ENST00000437974ARHGEF28chr572980709+ENST00000335960SEZ6chr1727296970-7225320721234
ENST00000426542ARHGEF28chr572980709+ENST00000360295SEZ6chr1727296970-322553202176718
ENST00000426542ARHGEF28chr572980709+ENST00000317338SEZ6chr1727296970-323753202179719
ENST00000426542ARHGEF28chr572980709+ENST00000442608SEZ6chr1727296970-295653202137705
ENST00000426542ARHGEF28chr572980709+ENST00000335960SEZ6chr1727296970-7225320721234

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000296794ENST00000360295ARHGEF28chr572980709+SEZ6chr1727296970-0.0106270070.989373
ENST00000296794ENST00000317338ARHGEF28chr572980709+SEZ6chr1727296970-0.0116486080.9883514
ENST00000296794ENST00000442608ARHGEF28chr572980709+SEZ6chr1727296970-0.0176816940.9823183
ENST00000296794ENST00000335960ARHGEF28chr572980709+SEZ6chr1727296970-0.096173730.9038263
ENST00000287898ENST00000360295ARHGEF28chr572980709+SEZ6chr1727296970-0.0106270070.989373
ENST00000287898ENST00000317338ARHGEF28chr572980709+SEZ6chr1727296970-0.0116486080.9883514
ENST00000287898ENST00000442608ARHGEF28chr572980709+SEZ6chr1727296970-0.0176816940.9823183
ENST00000287898ENST00000335960ARHGEF28chr572980709+SEZ6chr1727296970-0.096173730.9038263
ENST00000545377ENST00000360295ARHGEF28chr572980709+SEZ6chr1727296970-0.0106270070.989373
ENST00000545377ENST00000317338ARHGEF28chr572980709+SEZ6chr1727296970-0.0116486080.9883514
ENST00000545377ENST00000442608ARHGEF28chr572980709+SEZ6chr1727296970-0.0176816940.9823183
ENST00000545377ENST00000335960ARHGEF28chr572980709+SEZ6chr1727296970-0.096173730.9038263
ENST00000513042ENST00000360295ARHGEF28chr572980709+SEZ6chr1727296970-0.0106270070.989373
ENST00000513042ENST00000317338ARHGEF28chr572980709+SEZ6chr1727296970-0.0116486080.9883514
ENST00000513042ENST00000442608ARHGEF28chr572980709+SEZ6chr1727296970-0.0176816940.9823183
ENST00000513042ENST00000335960ARHGEF28chr572980709+SEZ6chr1727296970-0.096173730.9038263
ENST00000437974ENST00000360295ARHGEF28chr572980709+SEZ6chr1727296970-0.0103230990.9896769
ENST00000437974ENST00000317338ARHGEF28chr572980709+SEZ6chr1727296970-0.0112226280.98877734
ENST00000437974ENST00000442608ARHGEF28chr572980709+SEZ6chr1727296970-0.0177639160.982236
ENST00000437974ENST00000335960ARHGEF28chr572980709+SEZ6chr1727296970-0.092280840.9077192
ENST00000426542ENST00000360295ARHGEF28chr572980709+SEZ6chr1727296970-0.0103230990.9896769
ENST00000426542ENST00000317338ARHGEF28chr572980709+SEZ6chr1727296970-0.0112226280.98877734
ENST00000426542ENST00000442608ARHGEF28chr572980709+SEZ6chr1727296970-0.0177639160.982236
ENST00000426542ENST00000335960ARHGEF28chr572980709+SEZ6chr1727296970-0.092280840.9077192

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Fusion Genomic Features for RGNEF-SEZ6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for RGNEF-SEZ6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:72980709/:27296970)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSEZ6chr5:72980709chr17:27296970ENST00000317338217355_414286995.0DomainSushi 1
TgeneSEZ6chr5:72980709chr17:27296970ENST00000317338217416_527286995.0DomainCUB 1
TgeneSEZ6chr5:72980709chr17:27296970ENST00000317338217530_591286995.0DomainSushi 2
TgeneSEZ6chr5:72980709chr17:27296970ENST00000317338217593_704286995.0DomainCUB 2
TgeneSEZ6chr5:72980709chr17:27296970ENST00000317338217708_767286995.0DomainSushi 3
TgeneSEZ6chr5:72980709chr17:27296970ENST00000317338217769_832286995.0DomainSushi 4
TgeneSEZ6chr5:72980709chr17:27296970ENST00000317338217836_897286995.0DomainSushi 5
TgeneSEZ6chr5:72980709chr17:27296970ENST00000360295217355_414286994.0DomainSushi 1
TgeneSEZ6chr5:72980709chr17:27296970ENST00000360295217416_527286994.0DomainCUB 1
TgeneSEZ6chr5:72980709chr17:27296970ENST00000360295217530_591286994.0DomainSushi 2
TgeneSEZ6chr5:72980709chr17:27296970ENST00000360295217593_704286994.0DomainCUB 2
TgeneSEZ6chr5:72980709chr17:27296970ENST00000360295217708_767286994.0DomainSushi 3
TgeneSEZ6chr5:72980709chr17:27296970ENST00000360295217769_832286994.0DomainSushi 4
TgeneSEZ6chr5:72980709chr17:27296970ENST00000360295217836_897286994.0DomainSushi 5
TgeneSEZ6chr5:72980709chr17:27296970ENST00000317338217947_994286995.0Topological domainCytoplasmic
TgeneSEZ6chr5:72980709chr17:27296970ENST00000360295217947_994286994.0Topological domainCytoplasmic
TgeneSEZ6chr5:72980709chr17:27296970ENST00000317338217926_946286995.0TransmembraneHelical
TgeneSEZ6chr5:72980709chr17:27296970ENST00000360295217926_946286994.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000287898+2361488_1525111688.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000296794+2351488_1525111652.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000296799+1281488_152501393.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000426542+1351488_1525111706.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000437974+1361488_1525111732.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000513042+2361488_1525111706.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000545377+2371488_1525111732.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000287898+2361086_1188111688.0DomainPH
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000287898+236849_1044111688.0DomainDH
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000296794+2351086_1188111652.0DomainPH
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000296794+235849_1044111652.0DomainDH
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000296799+1281086_118801393.0DomainPH
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000296799+128849_104401393.0DomainDH
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000426542+1351086_1188111706.0DomainPH
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000426542+135849_1044111706.0DomainDH
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000437974+1361086_1188111732.0DomainPH
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000437974+136849_1044111732.0DomainDH
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000513042+2361086_1188111706.0DomainPH
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000513042+236849_1044111706.0DomainDH
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000545377+2371086_1188111732.0DomainPH
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000545377+237849_1044111732.0DomainDH
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000287898+2361496_1527111688.0RegionRNA-binding
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000296794+2351496_1527111652.0RegionRNA-binding
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000296799+1281496_152701393.0RegionRNA-binding
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000426542+1351496_1527111706.0RegionRNA-binding
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000437974+1361496_1527111732.0RegionRNA-binding
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000513042+2361496_1527111706.0RegionRNA-binding
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000545377+2371496_1527111732.0RegionRNA-binding
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000287898+236652_699111688.0Zinc fingerPhorbol-ester/DAG-type
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000296794+235652_699111652.0Zinc fingerPhorbol-ester/DAG-type
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000296799+128652_69901393.0Zinc fingerPhorbol-ester/DAG-type
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000426542+135652_699111706.0Zinc fingerPhorbol-ester/DAG-type
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000437974+136652_699111732.0Zinc fingerPhorbol-ester/DAG-type
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000513042+236652_699111706.0Zinc fingerPhorbol-ester/DAG-type
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000545377+237652_699111732.0Zinc fingerPhorbol-ester/DAG-type
TgeneSEZ6chr5:72980709chr17:27296970ENST00000317338217211_240286995.0Compositional biasNote=Thr-rich
TgeneSEZ6chr5:72980709chr17:27296970ENST0000031733821790_188286995.0Compositional biasNote=Pro-rich
TgeneSEZ6chr5:72980709chr17:27296970ENST00000360295217211_240286994.0Compositional biasNote=Thr-rich
TgeneSEZ6chr5:72980709chr17:27296970ENST0000036029521790_188286994.0Compositional biasNote=Pro-rich
TgeneSEZ6chr5:72980709chr17:27296970ENST0000031733821738_47286995.0RegionNote=O-glycosylated at two sites
TgeneSEZ6chr5:72980709chr17:27296970ENST0000031733821759_63286995.0RegionNote=O-glycosylated at two sites
TgeneSEZ6chr5:72980709chr17:27296970ENST0000036029521738_47286994.0RegionNote=O-glycosylated at two sites
TgeneSEZ6chr5:72980709chr17:27296970ENST0000036029521759_63286994.0RegionNote=O-glycosylated at two sites
TgeneSEZ6chr5:72980709chr17:27296970ENST0000031733821720_925286995.0Topological domainExtracellular
TgeneSEZ6chr5:72980709chr17:27296970ENST0000036029521720_925286994.0Topological domainExtracellular


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Fusion Gene Sequence for RGNEF-SEZ6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6278_6278_1_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000287898_SEZ6_chr17_27296970_ENST00000317338_length(transcript)=3393nt_BP=209nt
AAACCTTGGCTTCAGCCCGGCCGCCGCCAGGCGTTGGCATCGCCGGGGAGAGCCTTCCGGACTCCGGGCGGCGGCTGGCTGGGGGCGCGT
TCCGAGGCGCCCTCAGGCAGGGCGCGGGGGCAGAGCCTCGCCTGGGTTCTGGAGGCTGCGGGGCCATCGCTCCAGATGCGAAAGCCATGG
AGTTGAGCTGCAGCGAAGCACCTCTTTACGTCCAGAATATCAGCCTCCGGGAAGGGGAGACAGTGACTGTGGAAGGCCTGGGGGGGCCTG
ACCCACTGCCCCTGGCCAACCAGTCTTTCCTGCTGCGGGGCCAAGTCATCCGCAGCCCCACCCACCAAGCGGCCCTGAGGTTCCAGAGCC
TCCCGCCACCGGCTGGCCCTGGCACCTTCCATTTCCATTACCAAGCCTATCTCCTGAGCTGCCACTTTCCCCGTCGTCCAGCTTATGGAG
ATGTGACTGTCACCAGCCTCCACCCAGGGGGTAGTGCCCGCTTCCATTGTGCCACTGGCTACCAGCTGAAGGGCGCCAGGCATCTCACCT
GTCTCAATGCCACCCAGCCCTTCTGGGATTCAAAGGAGCCCGTCTGCATCGCTGCTTGCGGCGGAGTGATCCGCAATGCCACCACCGGCC
GCATCGTCTCTCCAGGCTTCCCGGGCAACTACAGCAACAACCTCACCTGTCACTGGCTGCTTGAGGCTCCTGAGGGCCAGCGGCTACACC
TGCACTTTGAGAAGGTTTCCCTGGCAGAGGATGATGACAGGCTCATCATTCGCAATGGGGACAACGTGGAGGCCCCACCAGTGTATGATT
CCTATGAGGTGGAATACCTGCCCATTGAGGGCCTGCTCAGCTCTGGCAAACACTTCTTTGTTGAGCTCAGTACTGACAGCAGCGGGGCAG
CTGCAGGCATGGCCCTGCGCTATGAGGCCTTCCAGCAGGGCCATTGCTATGAGCCCTTTGTCAAATACGGTAACTTCAGCAGCAGCACAC
CCACCTACCCTGTGGGTACCACTGTGGAGTTCAGCTGCGACCCTGGCTACACCCTGGAGCAGGGCTCCATCATCATCGAGTGTGTTGACC
CCCACGACCCCCAGTGGAATGAGACAGAGCCAGCCTGCCGAGCCGTGTGCAGCGGGGAGATCACAGACTCGGCTGGCGTGGTACTCTCTC
CCAACTGGCCAGAGCCCTACGGTCGTGGGCAGGATTGTATCTGGGGTGTGCATGTGGAAGAGGACAAGCGCATCATGCTGGACATCCGAG
TGCTGCGCATAGGCCCTGGTGATGTGCTTACCTTCTATGATGGGGATGACCTGACGGCCCGGGTTCTGGGCCAGTACTCAGGGCCCCGTA
GCCACTTCAAGCTCTTTACCTCCATGGCTGATGTCACCATTCAGTTCCAGTCGGACCCCGGGACCTCAGTGCTGGGCTACCAGCAGGGCT
TCGTCATCCACTTCTTTGAGGTGCCCCGCAATGACACATGTCCGGAGCTGCCTGAGATCCCCAATGGCTGGAAGAGCCCATCGCAGCCTG
AGCTAGTGCACGGCACCGTGGTCACTTACCAGTGCTACCCTGGCTACCAGGTAGTGGGATCCAGTGTCCTCATGTGCCAGTGGGACCTAA
CTTGGAGTGAGGACCTGCCCTCATGCCAGAGGGTGACTTCCTGCCACGATCCTGGAGATGTGGAGCACAGCCGACGCCTCATATCCAGCC
CCAAGTTTCCCGTGGGGGCCACCGTGCAATATATCTGTGACCAGGGTTTTGTGCTGATGGGCAGCTCCATCCTCACCTGCCATGATCGCC
AGGCTGGCAGCCCCAAGTGGAGTGACCGGGCCCCTAAATGTCTCCTGGAACAGCTCAAGCCATGCCATGGTCTCAGTGCCCCTGAGAATG
GTGCCCGAAGTCCTGAGAAGCAGCTACACCCAGCAGGGGCCACCATCCACTTCTCGTGTGCCCCTGGCTATGTGCTGAAGGGCCAGGCCA
GCATCAAGTGTGTGCCTGGGCACCCCTCGCATTGGAGTGACCCCCCACCCATCTGTAGGGCTGCCTCTCTGGATGGGTTCTACAACAGTC
GCAGCCTGGATGTTGCCAAGGCACCTGCTGCCTCCAGCACCCTGGATGCTGCCCACATTGCAGCTGCCATCTTCTTGCCACTGGTGGCGA
TGGTGTTGTTGGTAGGAGGTGTATACTTCTACTTCTCCAGGCTCCAGGGAAAAAGCTCCCTGCAGCTGCCCCGCCCCCGCCCCCGCCCCT
ACAACCGCATTACCATAGAGTCAGCGTTTGACAATCCAACTTACGAGACTGGATCTCTTTCCTTTGCAGGAGACGAGAGAATATGAAGTC
TCCATCTAGGTGGGGGCAGTCTAGGGAAGTCAACTCAGACTTGCACCACAGTCCAGCAGCAAGGCTCCTTGCTTCCTGCTGTCCCTCCAC
CTCCTGTATATACCACCTAGGAGGAGATGCCACCAAGCCCTCAAGAAGTTGTGCCCTTCCCCGCCTGCGATGCCCACCATGGCCTATTTT
CTTGGTGTCATTGCCCACTTGGGGCCCTTCATTGGGCCCATGTCAGGGGGCATCTACCTGTGGGAAGAACATAGCTGGAGCACAAGCATC
AACAGCCAGCATCCTGAGCCTCCTCATGCCCTGGACCAGCCTGGAACACACTAGCAGAGCAGGAGTACCTTTCTCCACATGACCACCATC
CCGCCCTGGCATGGCAACCTGCAGCAGGATTAACTTGACCATGGTGGGAACTGCACCAGGGTACTCCTCACAGCGCCATCACCAATGGCC
AAAACTCCTCTCAACGGTGACCTCTGGGTAGTCCTGGCATGCCAACATCAGCCTCTTGGGAGGTCTCTAGTTCTCTAAAGTTCTGGACAG
TTCTGCCTCCTGCCCTGTCCCAGTGGAGGCAGTAATTCTAGGAGATCCTAAGGGGTTCAGGGGGACCCTACCCCCACCTCAGGTTGGGCT
TCCCTGGGCACTCATGCTCCACACCAAAGCAGGACACGCCATTTTCCACTGACCACCCTATACCCTGAGGAAAGGGAGACTTTCCTCCGA
TGTTTATTTAGCTGTTGCAAACATCTTCACCCTAATAGTCCCTCCTCCAATTCCAGCCACTTGTCAGGCTCTCCTCTTGACCACTGTGTT
ATGGGATAAGGGGAGGGGGTGGGCATATTCTGGAGAGGAGCAGAGGTCCAAGGACCCAGGAATTTGGCATGGAACAGGTGGTAGGAGAGC
CCCAGGGAGACGCCCAGGAGCTGGCTGAAAGCCACTTTGTACATGTAATGTATTATATGGGGTCTGGGCTCCAGCCAGAGAACAATCTTT

>6278_6278_1_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000287898_SEZ6_chr17_27296970_ENST00000317338_length(amino acids)=776AA_BP=68
MASARPPPGVGIAGESLPDSGRRLAGGAFRGALRQGAGAEPRLGSGGCGAIAPDAKAMELSCSEAPLYVQNISLREGETVTVEGLGGPDP
LPLANQSFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLSCHFPRRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCL
NATQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSY
EVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEPFVKYGNFSSSTPTYPVGTTVEFSCDPGYTLEQGSIIIECVDPH
DPQWNETEPACRAVCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPGDVLTFYDGDDLTARVLGQYSGPRSH
FKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTW
SEDLPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHDRQAGSPKWSDRAPKCLLEQLKPCHGLSAPENGA
RSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGHPSHWSDPPPICRAASLDGFYNSRSLDVAKAPAASSTLDAAHIAAAIFLPLVAMV

--------------------------------------------------------------
>6278_6278_2_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000287898_SEZ6_chr17_27296970_ENST00000335960_length(transcript)=878nt_BP=209nt
AAACCTTGGCTTCAGCCCGGCCGCCGCCAGGCGTTGGCATCGCCGGGGAGAGCCTTCCGGACTCCGGGCGGCGGCTGGCTGGGGGCGCGT
TCCGAGGCGCCCTCAGGCAGGGCGCGGGGGCAGAGCCTCGCCTGGGTTCTGGAGGCTGCGGGGCCATCGCTCCAGATGCGAAAGCCATGG
AGTTGAGCTGCAGCGAAGCACCTCTTTACGTCCAGAATATCAGCCTCCGGGAAGGGGAGACAGTGACTGTGGAAGGCCTGGGGGGGCCTG
ACCCACTGCCCCTGGCCAACCAGTCTTTCCTGCTGCGGGGCCAAGTCATCCGCAGCCCCACCCACCAAGCGGCCCTGAGGTTCCAGAGCC
TCCCGCCACCGGCTGGCCCTGGCACCTTCCATTTCCATTACCAAGCCTATCTCCTGAGCTGCCACTTTCCCCGTCGTCCAGCTTATGGAG
ATGTGACTGTCACCAGCCTCCACCCAGGGGGTAGTGCCCGCTTCCATTGTGCCACTGGCTACCAGCTGAAGGGCGCCAGGCATCTCACCT
GTCTCAATGCCACCCAGCCCTTCTGGGATTCAAAGGAGCCCGTCTGCATCGCTGCTTGCGGCGGAGTGATCCGCAATGCCACCACCGGCC
GCATCGTCTCTCCAGGCTTCCCGGGCAACTACAGCAACAACCTCACCTGTCACTGGCTGCTTGAGGCTCCTGAGGGCCAGCGGCTACACC
TGCACTTTGAGAAGGTTTCCCTGGCAGAGGATGATGACAGGCTCATCATTCGCAATGGGGACAACGTGGAGGCCCCACCAGTGTATGATT

>6278_6278_2_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000287898_SEZ6_chr17_27296970_ENST00000335960_length(amino acids)=291AA_BP=68
MASARPPPGVGIAGESLPDSGRRLAGGAFRGALRQGAGAEPRLGSGGCGAIAPDAKAMELSCSEAPLYVQNISLREGETVTVEGLGGPDP
LPLANQSFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLSCHFPRRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCL
NATQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSY

--------------------------------------------------------------
>6278_6278_3_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000287898_SEZ6_chr17_27296970_ENST00000360295_length(transcript)=3381nt_BP=209nt
AAACCTTGGCTTCAGCCCGGCCGCCGCCAGGCGTTGGCATCGCCGGGGAGAGCCTTCCGGACTCCGGGCGGCGGCTGGCTGGGGGCGCGT
TCCGAGGCGCCCTCAGGCAGGGCGCGGGGGCAGAGCCTCGCCTGGGTTCTGGAGGCTGCGGGGCCATCGCTCCAGATGCGAAAGCCATGG
AGTTGAGCTGCAGCGAAGCACCTCTTTACGTCCAGAATATCAGCCTCCGGGAAGGGGAGACAGTGACTGTGGAAGGCCTGGGGGGGCCTG
ACCCACTGCCCCTGGCCAACCAGTCTTTCCTGCTGCGGGGCCAAGTCATCCGCAGCCCCACCCACCAAGCGGCCCTGAGGTTCCAGAGCC
TCCCGCCACCGGCTGGCCCTGGCACCTTCCATTTCCATTACCAAGCCTATCTCCTGAGCTGCCACTTTCCCCGTCGTCCAGCTTATGGAG
ATGTGACTGTCACCAGCCTCCACCCAGGGGGTAGTGCCCGCTTCCATTGTGCCACTGGCTACCAGCTGAAGGGCGCCAGGCATCTCACCT
GTCTCAATGCCACCCAGCCCTTCTGGGATTCAAAGGAGCCCGTCTGCATCGCTGCTTGCGGCGGAGTGATCCGCAATGCCACCACCGGCC
GCATCGTCTCTCCAGGCTTCCCGGGCAACTACAGCAACAACCTCACCTGTCACTGGCTGCTTGAGGCTCCTGAGGGCCAGCGGCTACACC
TGCACTTTGAGAAGGTTTCCCTGGCAGAGGATGATGACAGGCTCATCATTCGCAATGGGGACAACGTGGAGGCCCCACCAGTGTATGATT
CCTATGAGGTGGAATACCTGCCCATTGAGGGCCTGCTCAGCTCTGGCAAACACTTCTTTGTTGAGCTCAGTACTGACAGCAGCGGGGCAG
CTGCAGGCATGGCCCTGCGCTATGAGGCCTTCCAGCAGGGCCATTGCTATGAGCCCTTTGTCAAATACGGTAACTTCAGCAGCAGCACAC
CCACCTACCCTGTGGGTACCACTGTGGAGTTCAGCTGCGACCCTGGCTACACCCTGGAGCAGGGCTCCATCATCATCGAGTGTGTTGACC
CCCACGACCCCCAGTGGAATGAGACAGAGCCAGCCTGCCGAGCCGTGTGCAGCGGGGAGATCACAGACTCGGCTGGCGTGGTACTCTCTC
CCAACTGGCCAGAGCCCTACGGTCGTGGGCAGGATTGTATCTGGGGTGTGCATGTGGAAGAGGACAAGCGCATCATGCTGGACATCCGAG
TGCTGCGCATAGGCCCTGGTGATGTGCTTACCTTCTATGATGGGGATGACCTGACGGCCCGGGTTCTGGGCCAGTACTCAGGGCCCCGTA
GCCACTTCAAGCTCTTTACCTCCATGGCTGATGTCACCATTCAGTTCCAGTCGGACCCCGGGACCTCAGTGCTGGGCTACCAGCAGGGCT
TCGTCATCCACTTCTTTGAGGTGCCCCGCAATGACACATGTCCGGAGCTGCCTGAGATCCCCAATGGCTGGAAGAGCCCATCGCAGCCTG
AGCTAGTGCACGGCACCGTGGTCACTTACCAGTGCTACCCTGGCTACCAGGTAGTGGGATCCAGTGTCCTCATGTGCCAGTGGGACCTAA
CTTGGAGTGAGGACCTGCCCTCATGCCAGAGGGTGACTTCCTGCCACGATCCTGGAGATGTGGAGCACAGCCGACGCCTCATATCCAGCC
CCAAGTTTCCCGTGGGGGCCACCGTGCAATATATCTGTGACCAGGGTTTTGTGCTGATGGGCAGCTCCATCCTCACCTGCCATGATCGCC
AGGCTGGCAGCCCCAAGTGGAGTGACCGGGCCCCTAAATGTCTCCTGGAACAGCTCAAGCCATGCCATGGTCTCAGTGCCCCTGAGAATG
GTGCCCGAAGTCCTGAGAAGCAGCTACACCCAGCAGGGGCCACCATCCACTTCTCGTGTGCCCCTGGCTATGTGCTGAAGGGCCAGGCCA
GCATCAAGTGTGTGCCTGGGCACCCCTCGCATTGGAGTGACCCCCCACCCATCTGTAGGGCTGCCTCTCTGGATGGGTTCTACAACAGTC
GCAGCCTGGATGTTGCCAAGGCACCTGCTGCCTCCAGCACCCTGGATGCTGCCCACATTGCAGCTGCCATCTTCTTGCCACTGGTGGCGA
TGGTGTTGTTGGTAGGAGGTGTATACTTCTACTTCTCCAGGCTCCAGGGAAAAAGCTCCCTGCAGCTGCCCCGCCCCCGCCCCCGCCCCT
ACAACCGCATTACCATAGAGTCAGCGTTTGACAATCCAACTTACGAGACTGGAGAGACGAGAGAATATGAAGTCTCCATCTAGGTGGGGG
CAGTCTAGGGAAGTCAACTCAGACTTGCACCACAGTCCAGCAGCAAGGCTCCTTGCTTCCTGCTGTCCCTCCACCTCCTGTATATACCAC
CTAGGAGGAGATGCCACCAAGCCCTCAAGAAGTTGTGCCCTTCCCCGCCTGCGATGCCCACCATGGCCTATTTTCTTGGTGTCATTGCCC
ACTTGGGGCCCTTCATTGGGCCCATGTCAGGGGGCATCTACCTGTGGGAAGAACATAGCTGGAGCACAAGCATCAACAGCCAGCATCCTG
AGCCTCCTCATGCCCTGGACCAGCCTGGAACACACTAGCAGAGCAGGAGTACCTTTCTCCACATGACCACCATCCCGCCCTGGCATGGCA
ACCTGCAGCAGGATTAACTTGACCATGGTGGGAACTGCACCAGGGTACTCCTCACAGCGCCATCACCAATGGCCAAAACTCCTCTCAACG
GTGACCTCTGGGTAGTCCTGGCATGCCAACATCAGCCTCTTGGGAGGTCTCTAGTTCTCTAAAGTTCTGGACAGTTCTGCCTCCTGCCCT
GTCCCAGTGGAGGCAGTAATTCTAGGAGATCCTAAGGGGTTCAGGGGGACCCTACCCCCACCTCAGGTTGGGCTTCCCTGGGCACTCATG
CTCCACACCAAAGCAGGACACGCCATTTTCCACTGACCACCCTATACCCTGAGGAAAGGGAGACTTTCCTCCGATGTTTATTTAGCTGTT
GCAAACATCTTCACCCTAATAGTCCCTCCTCCAATTCCAGCCACTTGTCAGGCTCTCCTCTTGACCACTGTGTTATGGGATAAGGGGAGG
GGGTGGGCATATTCTGGAGAGGAGCAGAGGTCCAAGGACCCAGGAATTTGGCATGGAACAGGTGGTAGGAGAGCCCCAGGGAGACGCCCA
GGAGCTGGCTGAAAGCCACTTTGTACATGTAATGTATTATATGGGGTCTGGGCTCCAGCCAGAGAACAATCTTTTATTTCTGTTGTTTCC

>6278_6278_3_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000287898_SEZ6_chr17_27296970_ENST00000360295_length(amino acids)=775AA_BP=68
MASARPPPGVGIAGESLPDSGRRLAGGAFRGALRQGAGAEPRLGSGGCGAIAPDAKAMELSCSEAPLYVQNISLREGETVTVEGLGGPDP
LPLANQSFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLSCHFPRRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCL
NATQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSY
EVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEPFVKYGNFSSSTPTYPVGTTVEFSCDPGYTLEQGSIIIECVDPH
DPQWNETEPACRAVCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPGDVLTFYDGDDLTARVLGQYSGPRSH
FKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTW
SEDLPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHDRQAGSPKWSDRAPKCLLEQLKPCHGLSAPENGA
RSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGHPSHWSDPPPICRAASLDGFYNSRSLDVAKAPAASSTLDAAHIAAAIFLPLVAMV

--------------------------------------------------------------
>6278_6278_4_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000287898_SEZ6_chr17_27296970_ENST00000442608_length(transcript)=3112nt_BP=209nt
AAACCTTGGCTTCAGCCCGGCCGCCGCCAGGCGTTGGCATCGCCGGGGAGAGCCTTCCGGACTCCGGGCGGCGGCTGGCTGGGGGCGCGT
TCCGAGGCGCCCTCAGGCAGGGCGCGGGGGCAGAGCCTCGCCTGGGTTCTGGAGGCTGCGGGGCCATCGCTCCAGATGCGAAAGCCATGG
AGTTGAGCTGCAGCGAAGCACCTCTTTACGTCCAGAATATCAGCCTCCGGGAAGGGGAGACAGTGACTGTGGAAGGCCTGGGGGGGCCTG
ACCCACTGCCCCTGGCCAACCAGTCTTTCCTGCTGCGGGGCCAAGTCATCCGCAGCCCCACCCACCAAGCGGCCCTGAGGTTCCAGAGCC
TCCCGCCACCGGCTGGCCCTGGCACCTTCCATTTCCATTACCAAGCCTATCTCCTGAGCTGCCACTTTCCCCGTCGTCCAGCTTATGGAG
ATGTGACTGTCACCAGCCTCCACCCAGGGGGTAGTGCCCGCTTCCATTGTGCCACTGGCTACCAGCTGAAGGGCGCCAGGCATCTCACCT
GTCTCAATGCCACCCAGCCCTTCTGGGATTCAAAGGAGCCCGTCTGCATCGCTGCTTGCGGCGGAGTGATCCGCAATGCCACCACCGGCC
GCATCGTCTCTCCAGGCTTCCCGGGCAACTACAGCAACAACCTCACCTGTCACTGGCTGCTTGAGGCTCCTGAGGGCCAGCGGCTACACC
TGCACTTTGAGAAGGTTTCCCTGGCAGAGGATGATGACAGGCTCATCATTCGCAATGGGGACAACGTGGAGGCCCCACCAGTGTATGATT
CCTATGAGGTGGAATACCTGCCCATTGAGGGCCTGCTCAGCTCTGGCAAACACTTCTTTGTTGAGCTCAGTACTGACAGCAGCGGGGCAG
CTGCAGGCATGGCCCTGCGCTATGAGGCCTTCCAGCAGGGCCATTGCTATGAGCCCTTTGTCAAATACGGTAACTTCAGCAGCAGCACAC
CCACCTACCCTGTGGGTACCACTGTGGAGTTCAGCTGCGACCCTGGCTACACCCTGGAGCAGGGCTCCATCATCATCGAGTGTGTTGACC
CCCACGACCCCCAGTGGAATGAGACAGAGCCAGCCTGCCGAGCCGTGTGCAGCGGGGAGATCACAGACTCGGCTGGCGTGGTACTCTCTC
CCAACTGGCCAGAGCCCTACGGTCGTGGGCAGGATTGTATCTGGGGTGTGCATGTGGAAGAGGACAAGCGCATCATGCTGGACATCCGAG
TGCTGCGCATAGGCCCTGGTGATGTGCTTACCTTCTATGATGGGGATGACCTGACGGCCCGGGTTCTGGGCCAGTACTCAGGGCCCCGTA
GCCACTTCAAGCTCTTTACCTCCATGGCTGATGTCACCATTCAGTTCCAGTCGGACCCCGGGACCTCAGTGCTGGGCTACCAGCAGGGCT
TCGTCATCCACTTCTTTGAGGTGCCCCGCAATGACACATGTCCGGAGCTGCCTGAGATCCCCAATGGCTGGAAGAGCCCATCGCAGCCTG
AGCTAGTGCACGGCACCGTGGTCACTTACCAGTGCTACCCTGGCTACCAGGTAGTGGGATCCAGTGTCCTCATGTGCCAGTGGGACCTAA
CTTGGAGTGAGGACCTGCCCTCATGCCAGAGGGTGACTTCCTGCCACGATCCTGGAGATGTGGAGCACAGCCGACGCCTCATATCCAGCC
CCAAGTTTCCCGTGGGGGCCACCGTGCAATATATCTGTGACCAGGGTTTTGTGCTGATGGGCAGCTCCATCCTCACCTGCCATGATCGCC
AGGCTGGCAGCCCCAAGTGGAGTGACCGGGCCCCTAAATGTCTCCTGGAACAGCTCAAGCCATGCCATGGTCTCAGTGCCCCTGAGAATG
GTGCCCGAAGTCCTGAGAAGCAGCTACACCCAGCAGGGGCCACCATCCACTTCTCGTGTGCCCCTGGCTATGTGCTGAAGGGCCAGGCCA
GCATCAAGTGTGTGCCTGGGCACCCCTCGCATTGGAGTGACCCCCCACCCATCTGTAGGGCTGTTGCCAAGGCACCTGCTGCCTCCAGCA
CCCTGGATGCTGCCCACATTGCAGCTGCCATCTTCTTGCCACTGGTGGCGATGGTGTTGTTGGTAGGAGGTGTATACTTCTACTTCTCCA
GGCTCCAGGGAAAAAGCTCCCTGCAGCTGCCCCGCCCCCGCCCCCGCCCCTACAACCGCATTACCATAGAGTCAGCGTTTGACAATCCAA
CTTACGAGACTGGAGAGACGAGAGAATATGAAGTCTCCATCTAGGTGGGGGCAGTCTAGGGAAGTCAACTCAGACTTGCACCACAGTCCA
GCAGCAAGGCTCCTTGCTTCCTGCTGTCCCTCCACCTCCTGTATATACCACCTAGGAGGAGATGCCACCAAGCCCTCAAGAAGTTGTGCC
CTTCCCCGCCTGCGATGCCCACCATGGCCTATTTTCTTGGTGTCATTGCCCACTTGGGGCCCTTCATTGGGCCCATGTCAGGGGGCATCT
ACCTGTGGGAAGAACATAGCTGGAGCACAAGCATCAACAGCCAGCATCCTGAGCCTCCTCATGCCCTGGACCAGCCTGGAACACACTAGC
AGAGCAGGAGTACCTTTCTCCACATGACCACCATCCCGCCCTGGCATGGCAACCTGCAGCAGGATTAACTTGACCATGGTGGGAACTGCA
CCAGGGTACTCCTCACAGCGCCATCACCAATGGCCAAAACTCCTCTCAACGGTGACCTCTGGGTAGTCCTGGCATGCCAACATCAGCCTC
TTGGGAGGTCTCTAGTTCTCTAAAGTTCTGGACAGTTCTGCCTCCTGCCCTGTCCCAGTGGAGGCAGTAATTCTAGGAGATCCTAAGGGG
TTCAGGGGGACCCTACCCCCACCTCAGGTTGGGCTTCCCTGGGCACTCATGCTCCACACCAAAGCAGGACACGCCATTTTCCACTGACCA
CCCTATACCCTGAGGAAAGGGAGACTTTCCTCCGATGTTTATTTAGCTGTTGCAAACATCTTCACCCTAATAGTCCCTCCTCCAATTCCA

>6278_6278_4_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000287898_SEZ6_chr17_27296970_ENST00000442608_length(amino acids)=762AA_BP=68
MASARPPPGVGIAGESLPDSGRRLAGGAFRGALRQGAGAEPRLGSGGCGAIAPDAKAMELSCSEAPLYVQNISLREGETVTVEGLGGPDP
LPLANQSFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLSCHFPRRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCL
NATQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSY
EVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEPFVKYGNFSSSTPTYPVGTTVEFSCDPGYTLEQGSIIIECVDPH
DPQWNETEPACRAVCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPGDVLTFYDGDDLTARVLGQYSGPRSH
FKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTW
SEDLPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHDRQAGSPKWSDRAPKCLLEQLKPCHGLSAPENGA
RSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGHPSHWSDPPPICRAVAKAPAASSTLDAAHIAAAIFLPLVAMVLLVGGVYFYFSRL

--------------------------------------------------------------
>6278_6278_5_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000296794_SEZ6_chr17_27296970_ENST00000317338_length(transcript)=3393nt_BP=209nt
AAACCTTGGCTTCAGCCCGGCCGCCGCCAGGCGTTGGCATCGCCGGGGAGAGCCTTCCGGACTCCGGGCGGCGGCTGGCTGGGGGCGCGT
TCCGAGGCGCCCTCAGGCAGGGCGCGGGGGCAGAGCCTCGCCTGGGTTCTGGAGGCTGCGGGGCCATCGCTCCAGATGCGAAAGCCATGG
AGTTGAGCTGCAGCGAAGCACCTCTTTACGTCCAGAATATCAGCCTCCGGGAAGGGGAGACAGTGACTGTGGAAGGCCTGGGGGGGCCTG
ACCCACTGCCCCTGGCCAACCAGTCTTTCCTGCTGCGGGGCCAAGTCATCCGCAGCCCCACCCACCAAGCGGCCCTGAGGTTCCAGAGCC
TCCCGCCACCGGCTGGCCCTGGCACCTTCCATTTCCATTACCAAGCCTATCTCCTGAGCTGCCACTTTCCCCGTCGTCCAGCTTATGGAG
ATGTGACTGTCACCAGCCTCCACCCAGGGGGTAGTGCCCGCTTCCATTGTGCCACTGGCTACCAGCTGAAGGGCGCCAGGCATCTCACCT
GTCTCAATGCCACCCAGCCCTTCTGGGATTCAAAGGAGCCCGTCTGCATCGCTGCTTGCGGCGGAGTGATCCGCAATGCCACCACCGGCC
GCATCGTCTCTCCAGGCTTCCCGGGCAACTACAGCAACAACCTCACCTGTCACTGGCTGCTTGAGGCTCCTGAGGGCCAGCGGCTACACC
TGCACTTTGAGAAGGTTTCCCTGGCAGAGGATGATGACAGGCTCATCATTCGCAATGGGGACAACGTGGAGGCCCCACCAGTGTATGATT
CCTATGAGGTGGAATACCTGCCCATTGAGGGCCTGCTCAGCTCTGGCAAACACTTCTTTGTTGAGCTCAGTACTGACAGCAGCGGGGCAG
CTGCAGGCATGGCCCTGCGCTATGAGGCCTTCCAGCAGGGCCATTGCTATGAGCCCTTTGTCAAATACGGTAACTTCAGCAGCAGCACAC
CCACCTACCCTGTGGGTACCACTGTGGAGTTCAGCTGCGACCCTGGCTACACCCTGGAGCAGGGCTCCATCATCATCGAGTGTGTTGACC
CCCACGACCCCCAGTGGAATGAGACAGAGCCAGCCTGCCGAGCCGTGTGCAGCGGGGAGATCACAGACTCGGCTGGCGTGGTACTCTCTC
CCAACTGGCCAGAGCCCTACGGTCGTGGGCAGGATTGTATCTGGGGTGTGCATGTGGAAGAGGACAAGCGCATCATGCTGGACATCCGAG
TGCTGCGCATAGGCCCTGGTGATGTGCTTACCTTCTATGATGGGGATGACCTGACGGCCCGGGTTCTGGGCCAGTACTCAGGGCCCCGTA
GCCACTTCAAGCTCTTTACCTCCATGGCTGATGTCACCATTCAGTTCCAGTCGGACCCCGGGACCTCAGTGCTGGGCTACCAGCAGGGCT
TCGTCATCCACTTCTTTGAGGTGCCCCGCAATGACACATGTCCGGAGCTGCCTGAGATCCCCAATGGCTGGAAGAGCCCATCGCAGCCTG
AGCTAGTGCACGGCACCGTGGTCACTTACCAGTGCTACCCTGGCTACCAGGTAGTGGGATCCAGTGTCCTCATGTGCCAGTGGGACCTAA
CTTGGAGTGAGGACCTGCCCTCATGCCAGAGGGTGACTTCCTGCCACGATCCTGGAGATGTGGAGCACAGCCGACGCCTCATATCCAGCC
CCAAGTTTCCCGTGGGGGCCACCGTGCAATATATCTGTGACCAGGGTTTTGTGCTGATGGGCAGCTCCATCCTCACCTGCCATGATCGCC
AGGCTGGCAGCCCCAAGTGGAGTGACCGGGCCCCTAAATGTCTCCTGGAACAGCTCAAGCCATGCCATGGTCTCAGTGCCCCTGAGAATG
GTGCCCGAAGTCCTGAGAAGCAGCTACACCCAGCAGGGGCCACCATCCACTTCTCGTGTGCCCCTGGCTATGTGCTGAAGGGCCAGGCCA
GCATCAAGTGTGTGCCTGGGCACCCCTCGCATTGGAGTGACCCCCCACCCATCTGTAGGGCTGCCTCTCTGGATGGGTTCTACAACAGTC
GCAGCCTGGATGTTGCCAAGGCACCTGCTGCCTCCAGCACCCTGGATGCTGCCCACATTGCAGCTGCCATCTTCTTGCCACTGGTGGCGA
TGGTGTTGTTGGTAGGAGGTGTATACTTCTACTTCTCCAGGCTCCAGGGAAAAAGCTCCCTGCAGCTGCCCCGCCCCCGCCCCCGCCCCT
ACAACCGCATTACCATAGAGTCAGCGTTTGACAATCCAACTTACGAGACTGGATCTCTTTCCTTTGCAGGAGACGAGAGAATATGAAGTC
TCCATCTAGGTGGGGGCAGTCTAGGGAAGTCAACTCAGACTTGCACCACAGTCCAGCAGCAAGGCTCCTTGCTTCCTGCTGTCCCTCCAC
CTCCTGTATATACCACCTAGGAGGAGATGCCACCAAGCCCTCAAGAAGTTGTGCCCTTCCCCGCCTGCGATGCCCACCATGGCCTATTTT
CTTGGTGTCATTGCCCACTTGGGGCCCTTCATTGGGCCCATGTCAGGGGGCATCTACCTGTGGGAAGAACATAGCTGGAGCACAAGCATC
AACAGCCAGCATCCTGAGCCTCCTCATGCCCTGGACCAGCCTGGAACACACTAGCAGAGCAGGAGTACCTTTCTCCACATGACCACCATC
CCGCCCTGGCATGGCAACCTGCAGCAGGATTAACTTGACCATGGTGGGAACTGCACCAGGGTACTCCTCACAGCGCCATCACCAATGGCC
AAAACTCCTCTCAACGGTGACCTCTGGGTAGTCCTGGCATGCCAACATCAGCCTCTTGGGAGGTCTCTAGTTCTCTAAAGTTCTGGACAG
TTCTGCCTCCTGCCCTGTCCCAGTGGAGGCAGTAATTCTAGGAGATCCTAAGGGGTTCAGGGGGACCCTACCCCCACCTCAGGTTGGGCT
TCCCTGGGCACTCATGCTCCACACCAAAGCAGGACACGCCATTTTCCACTGACCACCCTATACCCTGAGGAAAGGGAGACTTTCCTCCGA
TGTTTATTTAGCTGTTGCAAACATCTTCACCCTAATAGTCCCTCCTCCAATTCCAGCCACTTGTCAGGCTCTCCTCTTGACCACTGTGTT
ATGGGATAAGGGGAGGGGGTGGGCATATTCTGGAGAGGAGCAGAGGTCCAAGGACCCAGGAATTTGGCATGGAACAGGTGGTAGGAGAGC
CCCAGGGAGACGCCCAGGAGCTGGCTGAAAGCCACTTTGTACATGTAATGTATTATATGGGGTCTGGGCTCCAGCCAGAGAACAATCTTT

>6278_6278_5_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000296794_SEZ6_chr17_27296970_ENST00000317338_length(amino acids)=776AA_BP=68
MASARPPPGVGIAGESLPDSGRRLAGGAFRGALRQGAGAEPRLGSGGCGAIAPDAKAMELSCSEAPLYVQNISLREGETVTVEGLGGPDP
LPLANQSFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLSCHFPRRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCL
NATQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSY
EVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEPFVKYGNFSSSTPTYPVGTTVEFSCDPGYTLEQGSIIIECVDPH
DPQWNETEPACRAVCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPGDVLTFYDGDDLTARVLGQYSGPRSH
FKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTW
SEDLPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHDRQAGSPKWSDRAPKCLLEQLKPCHGLSAPENGA
RSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGHPSHWSDPPPICRAASLDGFYNSRSLDVAKAPAASSTLDAAHIAAAIFLPLVAMV

--------------------------------------------------------------
>6278_6278_6_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000296794_SEZ6_chr17_27296970_ENST00000335960_length(transcript)=878nt_BP=209nt
AAACCTTGGCTTCAGCCCGGCCGCCGCCAGGCGTTGGCATCGCCGGGGAGAGCCTTCCGGACTCCGGGCGGCGGCTGGCTGGGGGCGCGT
TCCGAGGCGCCCTCAGGCAGGGCGCGGGGGCAGAGCCTCGCCTGGGTTCTGGAGGCTGCGGGGCCATCGCTCCAGATGCGAAAGCCATGG
AGTTGAGCTGCAGCGAAGCACCTCTTTACGTCCAGAATATCAGCCTCCGGGAAGGGGAGACAGTGACTGTGGAAGGCCTGGGGGGGCCTG
ACCCACTGCCCCTGGCCAACCAGTCTTTCCTGCTGCGGGGCCAAGTCATCCGCAGCCCCACCCACCAAGCGGCCCTGAGGTTCCAGAGCC
TCCCGCCACCGGCTGGCCCTGGCACCTTCCATTTCCATTACCAAGCCTATCTCCTGAGCTGCCACTTTCCCCGTCGTCCAGCTTATGGAG
ATGTGACTGTCACCAGCCTCCACCCAGGGGGTAGTGCCCGCTTCCATTGTGCCACTGGCTACCAGCTGAAGGGCGCCAGGCATCTCACCT
GTCTCAATGCCACCCAGCCCTTCTGGGATTCAAAGGAGCCCGTCTGCATCGCTGCTTGCGGCGGAGTGATCCGCAATGCCACCACCGGCC
GCATCGTCTCTCCAGGCTTCCCGGGCAACTACAGCAACAACCTCACCTGTCACTGGCTGCTTGAGGCTCCTGAGGGCCAGCGGCTACACC
TGCACTTTGAGAAGGTTTCCCTGGCAGAGGATGATGACAGGCTCATCATTCGCAATGGGGACAACGTGGAGGCCCCACCAGTGTATGATT

>6278_6278_6_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000296794_SEZ6_chr17_27296970_ENST00000335960_length(amino acids)=291AA_BP=68
MASARPPPGVGIAGESLPDSGRRLAGGAFRGALRQGAGAEPRLGSGGCGAIAPDAKAMELSCSEAPLYVQNISLREGETVTVEGLGGPDP
LPLANQSFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLSCHFPRRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCL
NATQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSY

--------------------------------------------------------------
>6278_6278_7_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000296794_SEZ6_chr17_27296970_ENST00000360295_length(transcript)=3381nt_BP=209nt
AAACCTTGGCTTCAGCCCGGCCGCCGCCAGGCGTTGGCATCGCCGGGGAGAGCCTTCCGGACTCCGGGCGGCGGCTGGCTGGGGGCGCGT
TCCGAGGCGCCCTCAGGCAGGGCGCGGGGGCAGAGCCTCGCCTGGGTTCTGGAGGCTGCGGGGCCATCGCTCCAGATGCGAAAGCCATGG
AGTTGAGCTGCAGCGAAGCACCTCTTTACGTCCAGAATATCAGCCTCCGGGAAGGGGAGACAGTGACTGTGGAAGGCCTGGGGGGGCCTG
ACCCACTGCCCCTGGCCAACCAGTCTTTCCTGCTGCGGGGCCAAGTCATCCGCAGCCCCACCCACCAAGCGGCCCTGAGGTTCCAGAGCC
TCCCGCCACCGGCTGGCCCTGGCACCTTCCATTTCCATTACCAAGCCTATCTCCTGAGCTGCCACTTTCCCCGTCGTCCAGCTTATGGAG
ATGTGACTGTCACCAGCCTCCACCCAGGGGGTAGTGCCCGCTTCCATTGTGCCACTGGCTACCAGCTGAAGGGCGCCAGGCATCTCACCT
GTCTCAATGCCACCCAGCCCTTCTGGGATTCAAAGGAGCCCGTCTGCATCGCTGCTTGCGGCGGAGTGATCCGCAATGCCACCACCGGCC
GCATCGTCTCTCCAGGCTTCCCGGGCAACTACAGCAACAACCTCACCTGTCACTGGCTGCTTGAGGCTCCTGAGGGCCAGCGGCTACACC
TGCACTTTGAGAAGGTTTCCCTGGCAGAGGATGATGACAGGCTCATCATTCGCAATGGGGACAACGTGGAGGCCCCACCAGTGTATGATT
CCTATGAGGTGGAATACCTGCCCATTGAGGGCCTGCTCAGCTCTGGCAAACACTTCTTTGTTGAGCTCAGTACTGACAGCAGCGGGGCAG
CTGCAGGCATGGCCCTGCGCTATGAGGCCTTCCAGCAGGGCCATTGCTATGAGCCCTTTGTCAAATACGGTAACTTCAGCAGCAGCACAC
CCACCTACCCTGTGGGTACCACTGTGGAGTTCAGCTGCGACCCTGGCTACACCCTGGAGCAGGGCTCCATCATCATCGAGTGTGTTGACC
CCCACGACCCCCAGTGGAATGAGACAGAGCCAGCCTGCCGAGCCGTGTGCAGCGGGGAGATCACAGACTCGGCTGGCGTGGTACTCTCTC
CCAACTGGCCAGAGCCCTACGGTCGTGGGCAGGATTGTATCTGGGGTGTGCATGTGGAAGAGGACAAGCGCATCATGCTGGACATCCGAG
TGCTGCGCATAGGCCCTGGTGATGTGCTTACCTTCTATGATGGGGATGACCTGACGGCCCGGGTTCTGGGCCAGTACTCAGGGCCCCGTA
GCCACTTCAAGCTCTTTACCTCCATGGCTGATGTCACCATTCAGTTCCAGTCGGACCCCGGGACCTCAGTGCTGGGCTACCAGCAGGGCT
TCGTCATCCACTTCTTTGAGGTGCCCCGCAATGACACATGTCCGGAGCTGCCTGAGATCCCCAATGGCTGGAAGAGCCCATCGCAGCCTG
AGCTAGTGCACGGCACCGTGGTCACTTACCAGTGCTACCCTGGCTACCAGGTAGTGGGATCCAGTGTCCTCATGTGCCAGTGGGACCTAA
CTTGGAGTGAGGACCTGCCCTCATGCCAGAGGGTGACTTCCTGCCACGATCCTGGAGATGTGGAGCACAGCCGACGCCTCATATCCAGCC
CCAAGTTTCCCGTGGGGGCCACCGTGCAATATATCTGTGACCAGGGTTTTGTGCTGATGGGCAGCTCCATCCTCACCTGCCATGATCGCC
AGGCTGGCAGCCCCAAGTGGAGTGACCGGGCCCCTAAATGTCTCCTGGAACAGCTCAAGCCATGCCATGGTCTCAGTGCCCCTGAGAATG
GTGCCCGAAGTCCTGAGAAGCAGCTACACCCAGCAGGGGCCACCATCCACTTCTCGTGTGCCCCTGGCTATGTGCTGAAGGGCCAGGCCA
GCATCAAGTGTGTGCCTGGGCACCCCTCGCATTGGAGTGACCCCCCACCCATCTGTAGGGCTGCCTCTCTGGATGGGTTCTACAACAGTC
GCAGCCTGGATGTTGCCAAGGCACCTGCTGCCTCCAGCACCCTGGATGCTGCCCACATTGCAGCTGCCATCTTCTTGCCACTGGTGGCGA
TGGTGTTGTTGGTAGGAGGTGTATACTTCTACTTCTCCAGGCTCCAGGGAAAAAGCTCCCTGCAGCTGCCCCGCCCCCGCCCCCGCCCCT
ACAACCGCATTACCATAGAGTCAGCGTTTGACAATCCAACTTACGAGACTGGAGAGACGAGAGAATATGAAGTCTCCATCTAGGTGGGGG
CAGTCTAGGGAAGTCAACTCAGACTTGCACCACAGTCCAGCAGCAAGGCTCCTTGCTTCCTGCTGTCCCTCCACCTCCTGTATATACCAC
CTAGGAGGAGATGCCACCAAGCCCTCAAGAAGTTGTGCCCTTCCCCGCCTGCGATGCCCACCATGGCCTATTTTCTTGGTGTCATTGCCC
ACTTGGGGCCCTTCATTGGGCCCATGTCAGGGGGCATCTACCTGTGGGAAGAACATAGCTGGAGCACAAGCATCAACAGCCAGCATCCTG
AGCCTCCTCATGCCCTGGACCAGCCTGGAACACACTAGCAGAGCAGGAGTACCTTTCTCCACATGACCACCATCCCGCCCTGGCATGGCA
ACCTGCAGCAGGATTAACTTGACCATGGTGGGAACTGCACCAGGGTACTCCTCACAGCGCCATCACCAATGGCCAAAACTCCTCTCAACG
GTGACCTCTGGGTAGTCCTGGCATGCCAACATCAGCCTCTTGGGAGGTCTCTAGTTCTCTAAAGTTCTGGACAGTTCTGCCTCCTGCCCT
GTCCCAGTGGAGGCAGTAATTCTAGGAGATCCTAAGGGGTTCAGGGGGACCCTACCCCCACCTCAGGTTGGGCTTCCCTGGGCACTCATG
CTCCACACCAAAGCAGGACACGCCATTTTCCACTGACCACCCTATACCCTGAGGAAAGGGAGACTTTCCTCCGATGTTTATTTAGCTGTT
GCAAACATCTTCACCCTAATAGTCCCTCCTCCAATTCCAGCCACTTGTCAGGCTCTCCTCTTGACCACTGTGTTATGGGATAAGGGGAGG
GGGTGGGCATATTCTGGAGAGGAGCAGAGGTCCAAGGACCCAGGAATTTGGCATGGAACAGGTGGTAGGAGAGCCCCAGGGAGACGCCCA
GGAGCTGGCTGAAAGCCACTTTGTACATGTAATGTATTATATGGGGTCTGGGCTCCAGCCAGAGAACAATCTTTTATTTCTGTTGTTTCC

>6278_6278_7_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000296794_SEZ6_chr17_27296970_ENST00000360295_length(amino acids)=775AA_BP=68
MASARPPPGVGIAGESLPDSGRRLAGGAFRGALRQGAGAEPRLGSGGCGAIAPDAKAMELSCSEAPLYVQNISLREGETVTVEGLGGPDP
LPLANQSFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLSCHFPRRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCL
NATQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSY
EVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEPFVKYGNFSSSTPTYPVGTTVEFSCDPGYTLEQGSIIIECVDPH
DPQWNETEPACRAVCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPGDVLTFYDGDDLTARVLGQYSGPRSH
FKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTW
SEDLPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHDRQAGSPKWSDRAPKCLLEQLKPCHGLSAPENGA
RSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGHPSHWSDPPPICRAASLDGFYNSRSLDVAKAPAASSTLDAAHIAAAIFLPLVAMV

--------------------------------------------------------------
>6278_6278_8_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000296794_SEZ6_chr17_27296970_ENST00000442608_length(transcript)=3112nt_BP=209nt
AAACCTTGGCTTCAGCCCGGCCGCCGCCAGGCGTTGGCATCGCCGGGGAGAGCCTTCCGGACTCCGGGCGGCGGCTGGCTGGGGGCGCGT
TCCGAGGCGCCCTCAGGCAGGGCGCGGGGGCAGAGCCTCGCCTGGGTTCTGGAGGCTGCGGGGCCATCGCTCCAGATGCGAAAGCCATGG
AGTTGAGCTGCAGCGAAGCACCTCTTTACGTCCAGAATATCAGCCTCCGGGAAGGGGAGACAGTGACTGTGGAAGGCCTGGGGGGGCCTG
ACCCACTGCCCCTGGCCAACCAGTCTTTCCTGCTGCGGGGCCAAGTCATCCGCAGCCCCACCCACCAAGCGGCCCTGAGGTTCCAGAGCC
TCCCGCCACCGGCTGGCCCTGGCACCTTCCATTTCCATTACCAAGCCTATCTCCTGAGCTGCCACTTTCCCCGTCGTCCAGCTTATGGAG
ATGTGACTGTCACCAGCCTCCACCCAGGGGGTAGTGCCCGCTTCCATTGTGCCACTGGCTACCAGCTGAAGGGCGCCAGGCATCTCACCT
GTCTCAATGCCACCCAGCCCTTCTGGGATTCAAAGGAGCCCGTCTGCATCGCTGCTTGCGGCGGAGTGATCCGCAATGCCACCACCGGCC
GCATCGTCTCTCCAGGCTTCCCGGGCAACTACAGCAACAACCTCACCTGTCACTGGCTGCTTGAGGCTCCTGAGGGCCAGCGGCTACACC
TGCACTTTGAGAAGGTTTCCCTGGCAGAGGATGATGACAGGCTCATCATTCGCAATGGGGACAACGTGGAGGCCCCACCAGTGTATGATT
CCTATGAGGTGGAATACCTGCCCATTGAGGGCCTGCTCAGCTCTGGCAAACACTTCTTTGTTGAGCTCAGTACTGACAGCAGCGGGGCAG
CTGCAGGCATGGCCCTGCGCTATGAGGCCTTCCAGCAGGGCCATTGCTATGAGCCCTTTGTCAAATACGGTAACTTCAGCAGCAGCACAC
CCACCTACCCTGTGGGTACCACTGTGGAGTTCAGCTGCGACCCTGGCTACACCCTGGAGCAGGGCTCCATCATCATCGAGTGTGTTGACC
CCCACGACCCCCAGTGGAATGAGACAGAGCCAGCCTGCCGAGCCGTGTGCAGCGGGGAGATCACAGACTCGGCTGGCGTGGTACTCTCTC
CCAACTGGCCAGAGCCCTACGGTCGTGGGCAGGATTGTATCTGGGGTGTGCATGTGGAAGAGGACAAGCGCATCATGCTGGACATCCGAG
TGCTGCGCATAGGCCCTGGTGATGTGCTTACCTTCTATGATGGGGATGACCTGACGGCCCGGGTTCTGGGCCAGTACTCAGGGCCCCGTA
GCCACTTCAAGCTCTTTACCTCCATGGCTGATGTCACCATTCAGTTCCAGTCGGACCCCGGGACCTCAGTGCTGGGCTACCAGCAGGGCT
TCGTCATCCACTTCTTTGAGGTGCCCCGCAATGACACATGTCCGGAGCTGCCTGAGATCCCCAATGGCTGGAAGAGCCCATCGCAGCCTG
AGCTAGTGCACGGCACCGTGGTCACTTACCAGTGCTACCCTGGCTACCAGGTAGTGGGATCCAGTGTCCTCATGTGCCAGTGGGACCTAA
CTTGGAGTGAGGACCTGCCCTCATGCCAGAGGGTGACTTCCTGCCACGATCCTGGAGATGTGGAGCACAGCCGACGCCTCATATCCAGCC
CCAAGTTTCCCGTGGGGGCCACCGTGCAATATATCTGTGACCAGGGTTTTGTGCTGATGGGCAGCTCCATCCTCACCTGCCATGATCGCC
AGGCTGGCAGCCCCAAGTGGAGTGACCGGGCCCCTAAATGTCTCCTGGAACAGCTCAAGCCATGCCATGGTCTCAGTGCCCCTGAGAATG
GTGCCCGAAGTCCTGAGAAGCAGCTACACCCAGCAGGGGCCACCATCCACTTCTCGTGTGCCCCTGGCTATGTGCTGAAGGGCCAGGCCA
GCATCAAGTGTGTGCCTGGGCACCCCTCGCATTGGAGTGACCCCCCACCCATCTGTAGGGCTGTTGCCAAGGCACCTGCTGCCTCCAGCA
CCCTGGATGCTGCCCACATTGCAGCTGCCATCTTCTTGCCACTGGTGGCGATGGTGTTGTTGGTAGGAGGTGTATACTTCTACTTCTCCA
GGCTCCAGGGAAAAAGCTCCCTGCAGCTGCCCCGCCCCCGCCCCCGCCCCTACAACCGCATTACCATAGAGTCAGCGTTTGACAATCCAA
CTTACGAGACTGGAGAGACGAGAGAATATGAAGTCTCCATCTAGGTGGGGGCAGTCTAGGGAAGTCAACTCAGACTTGCACCACAGTCCA
GCAGCAAGGCTCCTTGCTTCCTGCTGTCCCTCCACCTCCTGTATATACCACCTAGGAGGAGATGCCACCAAGCCCTCAAGAAGTTGTGCC
CTTCCCCGCCTGCGATGCCCACCATGGCCTATTTTCTTGGTGTCATTGCCCACTTGGGGCCCTTCATTGGGCCCATGTCAGGGGGCATCT
ACCTGTGGGAAGAACATAGCTGGAGCACAAGCATCAACAGCCAGCATCCTGAGCCTCCTCATGCCCTGGACCAGCCTGGAACACACTAGC
AGAGCAGGAGTACCTTTCTCCACATGACCACCATCCCGCCCTGGCATGGCAACCTGCAGCAGGATTAACTTGACCATGGTGGGAACTGCA
CCAGGGTACTCCTCACAGCGCCATCACCAATGGCCAAAACTCCTCTCAACGGTGACCTCTGGGTAGTCCTGGCATGCCAACATCAGCCTC
TTGGGAGGTCTCTAGTTCTCTAAAGTTCTGGACAGTTCTGCCTCCTGCCCTGTCCCAGTGGAGGCAGTAATTCTAGGAGATCCTAAGGGG
TTCAGGGGGACCCTACCCCCACCTCAGGTTGGGCTTCCCTGGGCACTCATGCTCCACACCAAAGCAGGACACGCCATTTTCCACTGACCA
CCCTATACCCTGAGGAAAGGGAGACTTTCCTCCGATGTTTATTTAGCTGTTGCAAACATCTTCACCCTAATAGTCCCTCCTCCAATTCCA

>6278_6278_8_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000296794_SEZ6_chr17_27296970_ENST00000442608_length(amino acids)=762AA_BP=68
MASARPPPGVGIAGESLPDSGRRLAGGAFRGALRQGAGAEPRLGSGGCGAIAPDAKAMELSCSEAPLYVQNISLREGETVTVEGLGGPDP
LPLANQSFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLSCHFPRRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCL
NATQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSY
EVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEPFVKYGNFSSSTPTYPVGTTVEFSCDPGYTLEQGSIIIECVDPH
DPQWNETEPACRAVCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPGDVLTFYDGDDLTARVLGQYSGPRSH
FKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTW
SEDLPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHDRQAGSPKWSDRAPKCLLEQLKPCHGLSAPENGA
RSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGHPSHWSDPPPICRAVAKAPAASSTLDAAHIAAAIFLPLVAMVLLVGGVYFYFSRL

--------------------------------------------------------------
>6278_6278_9_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000426542_SEZ6_chr17_27296970_ENST00000317338_length(transcript)=3237nt_BP=53nt
TCATTGCAGATGCGAAAGCCATGGAGTTGAGCTGCAGCGAAGCACCTCTTTACGTCCAGAATATCAGCCTCCGGGAAGGGGAGACAGTGA
CTGTGGAAGGCCTGGGGGGGCCTGACCCACTGCCCCTGGCCAACCAGTCTTTCCTGCTGCGGGGCCAAGTCATCCGCAGCCCCACCCACC
AAGCGGCCCTGAGGTTCCAGAGCCTCCCGCCACCGGCTGGCCCTGGCACCTTCCATTTCCATTACCAAGCCTATCTCCTGAGCTGCCACT
TTCCCCGTCGTCCAGCTTATGGAGATGTGACTGTCACCAGCCTCCACCCAGGGGGTAGTGCCCGCTTCCATTGTGCCACTGGCTACCAGC
TGAAGGGCGCCAGGCATCTCACCTGTCTCAATGCCACCCAGCCCTTCTGGGATTCAAAGGAGCCCGTCTGCATCGCTGCTTGCGGCGGAG
TGATCCGCAATGCCACCACCGGCCGCATCGTCTCTCCAGGCTTCCCGGGCAACTACAGCAACAACCTCACCTGTCACTGGCTGCTTGAGG
CTCCTGAGGGCCAGCGGCTACACCTGCACTTTGAGAAGGTTTCCCTGGCAGAGGATGATGACAGGCTCATCATTCGCAATGGGGACAACG
TGGAGGCCCCACCAGTGTATGATTCCTATGAGGTGGAATACCTGCCCATTGAGGGCCTGCTCAGCTCTGGCAAACACTTCTTTGTTGAGC
TCAGTACTGACAGCAGCGGGGCAGCTGCAGGCATGGCCCTGCGCTATGAGGCCTTCCAGCAGGGCCATTGCTATGAGCCCTTTGTCAAAT
ACGGTAACTTCAGCAGCAGCACACCCACCTACCCTGTGGGTACCACTGTGGAGTTCAGCTGCGACCCTGGCTACACCCTGGAGCAGGGCT
CCATCATCATCGAGTGTGTTGACCCCCACGACCCCCAGTGGAATGAGACAGAGCCAGCCTGCCGAGCCGTGTGCAGCGGGGAGATCACAG
ACTCGGCTGGCGTGGTACTCTCTCCCAACTGGCCAGAGCCCTACGGTCGTGGGCAGGATTGTATCTGGGGTGTGCATGTGGAAGAGGACA
AGCGCATCATGCTGGACATCCGAGTGCTGCGCATAGGCCCTGGTGATGTGCTTACCTTCTATGATGGGGATGACCTGACGGCCCGGGTTC
TGGGCCAGTACTCAGGGCCCCGTAGCCACTTCAAGCTCTTTACCTCCATGGCTGATGTCACCATTCAGTTCCAGTCGGACCCCGGGACCT
CAGTGCTGGGCTACCAGCAGGGCTTCGTCATCCACTTCTTTGAGGTGCCCCGCAATGACACATGTCCGGAGCTGCCTGAGATCCCCAATG
GCTGGAAGAGCCCATCGCAGCCTGAGCTAGTGCACGGCACCGTGGTCACTTACCAGTGCTACCCTGGCTACCAGGTAGTGGGATCCAGTG
TCCTCATGTGCCAGTGGGACCTAACTTGGAGTGAGGACCTGCCCTCATGCCAGAGGGTGACTTCCTGCCACGATCCTGGAGATGTGGAGC
ACAGCCGACGCCTCATATCCAGCCCCAAGTTTCCCGTGGGGGCCACCGTGCAATATATCTGTGACCAGGGTTTTGTGCTGATGGGCAGCT
CCATCCTCACCTGCCATGATCGCCAGGCTGGCAGCCCCAAGTGGAGTGACCGGGCCCCTAAATGTCTCCTGGAACAGCTCAAGCCATGCC
ATGGTCTCAGTGCCCCTGAGAATGGTGCCCGAAGTCCTGAGAAGCAGCTACACCCAGCAGGGGCCACCATCCACTTCTCGTGTGCCCCTG
GCTATGTGCTGAAGGGCCAGGCCAGCATCAAGTGTGTGCCTGGGCACCCCTCGCATTGGAGTGACCCCCCACCCATCTGTAGGGCTGCCT
CTCTGGATGGGTTCTACAACAGTCGCAGCCTGGATGTTGCCAAGGCACCTGCTGCCTCCAGCACCCTGGATGCTGCCCACATTGCAGCTG
CCATCTTCTTGCCACTGGTGGCGATGGTGTTGTTGGTAGGAGGTGTATACTTCTACTTCTCCAGGCTCCAGGGAAAAAGCTCCCTGCAGC
TGCCCCGCCCCCGCCCCCGCCCCTACAACCGCATTACCATAGAGTCAGCGTTTGACAATCCAACTTACGAGACTGGATCTCTTTCCTTTG
CAGGAGACGAGAGAATATGAAGTCTCCATCTAGGTGGGGGCAGTCTAGGGAAGTCAACTCAGACTTGCACCACAGTCCAGCAGCAAGGCT
CCTTGCTTCCTGCTGTCCCTCCACCTCCTGTATATACCACCTAGGAGGAGATGCCACCAAGCCCTCAAGAAGTTGTGCCCTTCCCCGCCT
GCGATGCCCACCATGGCCTATTTTCTTGGTGTCATTGCCCACTTGGGGCCCTTCATTGGGCCCATGTCAGGGGGCATCTACCTGTGGGAA
GAACATAGCTGGAGCACAAGCATCAACAGCCAGCATCCTGAGCCTCCTCATGCCCTGGACCAGCCTGGAACACACTAGCAGAGCAGGAGT
ACCTTTCTCCACATGACCACCATCCCGCCCTGGCATGGCAACCTGCAGCAGGATTAACTTGACCATGGTGGGAACTGCACCAGGGTACTC
CTCACAGCGCCATCACCAATGGCCAAAACTCCTCTCAACGGTGACCTCTGGGTAGTCCTGGCATGCCAACATCAGCCTCTTGGGAGGTCT
CTAGTTCTCTAAAGTTCTGGACAGTTCTGCCTCCTGCCCTGTCCCAGTGGAGGCAGTAATTCTAGGAGATCCTAAGGGGTTCAGGGGGAC
CCTACCCCCACCTCAGGTTGGGCTTCCCTGGGCACTCATGCTCCACACCAAAGCAGGACACGCCATTTTCCACTGACCACCCTATACCCT
GAGGAAAGGGAGACTTTCCTCCGATGTTTATTTAGCTGTTGCAAACATCTTCACCCTAATAGTCCCTCCTCCAATTCCAGCCACTTGTCA
GGCTCTCCTCTTGACCACTGTGTTATGGGATAAGGGGAGGGGGTGGGCATATTCTGGAGAGGAGCAGAGGTCCAAGGACCCAGGAATTTG
GCATGGAACAGGTGGTAGGAGAGCCCCAGGGAGACGCCCAGGAGCTGGCTGAAAGCCACTTTGTACATGTAATGTATTATATGGGGTCTG

>6278_6278_9_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000426542_SEZ6_chr17_27296970_ENST00000317338_length(amino acids)=719AA_BP=11
MELSCSEAPLYVQNISLREGETVTVEGLGGPDPLPLANQSFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLSCHFPRRPAY
GDVTVTSLHPGGSARFHCATGYQLKGARHLTCLNATQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRL
HLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSYEVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEPFVKYGNFSSS
TPTYPVGTTVEFSCDPGYTLEQGSIIIECVDPHDPQWNETEPACRAVCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDI
RVLRIGPGDVLTFYDGDDLTARVLGQYSGPRSHFKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCPELPEIPNGWKSPSQ
PELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHD
RQAGSPKWSDRAPKCLLEQLKPCHGLSAPENGARSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGHPSHWSDPPPICRAASLDGFYN

--------------------------------------------------------------
>6278_6278_10_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000426542_SEZ6_chr17_27296970_ENST00000335960_length(transcript)=722nt_BP=53nt
TCATTGCAGATGCGAAAGCCATGGAGTTGAGCTGCAGCGAAGCACCTCTTTACGTCCAGAATATCAGCCTCCGGGAAGGGGAGACAGTGA
CTGTGGAAGGCCTGGGGGGGCCTGACCCACTGCCCCTGGCCAACCAGTCTTTCCTGCTGCGGGGCCAAGTCATCCGCAGCCCCACCCACC
AAGCGGCCCTGAGGTTCCAGAGCCTCCCGCCACCGGCTGGCCCTGGCACCTTCCATTTCCATTACCAAGCCTATCTCCTGAGCTGCCACT
TTCCCCGTCGTCCAGCTTATGGAGATGTGACTGTCACCAGCCTCCACCCAGGGGGTAGTGCCCGCTTCCATTGTGCCACTGGCTACCAGC
TGAAGGGCGCCAGGCATCTCACCTGTCTCAATGCCACCCAGCCCTTCTGGGATTCAAAGGAGCCCGTCTGCATCGCTGCTTGCGGCGGAG
TGATCCGCAATGCCACCACCGGCCGCATCGTCTCTCCAGGCTTCCCGGGCAACTACAGCAACAACCTCACCTGTCACTGGCTGCTTGAGG
CTCCTGAGGGCCAGCGGCTACACCTGCACTTTGAGAAGGTTTCCCTGGCAGAGGATGATGACAGGCTCATCATTCGCAATGGGGACAACG
TGGAGGCCCCACCAGTGTATGATTCCTATGAGGTGACTGCCCCGCCCCCGCCCCCGCCCCTACAACCGCATTACCATAGAGTCAGCGTTT

>6278_6278_10_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000426542_SEZ6_chr17_27296970_ENST00000335960_length(amino acids)=234AA_BP=11
MELSCSEAPLYVQNISLREGETVTVEGLGGPDPLPLANQSFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLSCHFPRRPAY
GDVTVTSLHPGGSARFHCATGYQLKGARHLTCLNATQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRL

--------------------------------------------------------------
>6278_6278_11_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000426542_SEZ6_chr17_27296970_ENST00000360295_length(transcript)=3225nt_BP=53nt
TCATTGCAGATGCGAAAGCCATGGAGTTGAGCTGCAGCGAAGCACCTCTTTACGTCCAGAATATCAGCCTCCGGGAAGGGGAGACAGTGA
CTGTGGAAGGCCTGGGGGGGCCTGACCCACTGCCCCTGGCCAACCAGTCTTTCCTGCTGCGGGGCCAAGTCATCCGCAGCCCCACCCACC
AAGCGGCCCTGAGGTTCCAGAGCCTCCCGCCACCGGCTGGCCCTGGCACCTTCCATTTCCATTACCAAGCCTATCTCCTGAGCTGCCACT
TTCCCCGTCGTCCAGCTTATGGAGATGTGACTGTCACCAGCCTCCACCCAGGGGGTAGTGCCCGCTTCCATTGTGCCACTGGCTACCAGC
TGAAGGGCGCCAGGCATCTCACCTGTCTCAATGCCACCCAGCCCTTCTGGGATTCAAAGGAGCCCGTCTGCATCGCTGCTTGCGGCGGAG
TGATCCGCAATGCCACCACCGGCCGCATCGTCTCTCCAGGCTTCCCGGGCAACTACAGCAACAACCTCACCTGTCACTGGCTGCTTGAGG
CTCCTGAGGGCCAGCGGCTACACCTGCACTTTGAGAAGGTTTCCCTGGCAGAGGATGATGACAGGCTCATCATTCGCAATGGGGACAACG
TGGAGGCCCCACCAGTGTATGATTCCTATGAGGTGGAATACCTGCCCATTGAGGGCCTGCTCAGCTCTGGCAAACACTTCTTTGTTGAGC
TCAGTACTGACAGCAGCGGGGCAGCTGCAGGCATGGCCCTGCGCTATGAGGCCTTCCAGCAGGGCCATTGCTATGAGCCCTTTGTCAAAT
ACGGTAACTTCAGCAGCAGCACACCCACCTACCCTGTGGGTACCACTGTGGAGTTCAGCTGCGACCCTGGCTACACCCTGGAGCAGGGCT
CCATCATCATCGAGTGTGTTGACCCCCACGACCCCCAGTGGAATGAGACAGAGCCAGCCTGCCGAGCCGTGTGCAGCGGGGAGATCACAG
ACTCGGCTGGCGTGGTACTCTCTCCCAACTGGCCAGAGCCCTACGGTCGTGGGCAGGATTGTATCTGGGGTGTGCATGTGGAAGAGGACA
AGCGCATCATGCTGGACATCCGAGTGCTGCGCATAGGCCCTGGTGATGTGCTTACCTTCTATGATGGGGATGACCTGACGGCCCGGGTTC
TGGGCCAGTACTCAGGGCCCCGTAGCCACTTCAAGCTCTTTACCTCCATGGCTGATGTCACCATTCAGTTCCAGTCGGACCCCGGGACCT
CAGTGCTGGGCTACCAGCAGGGCTTCGTCATCCACTTCTTTGAGGTGCCCCGCAATGACACATGTCCGGAGCTGCCTGAGATCCCCAATG
GCTGGAAGAGCCCATCGCAGCCTGAGCTAGTGCACGGCACCGTGGTCACTTACCAGTGCTACCCTGGCTACCAGGTAGTGGGATCCAGTG
TCCTCATGTGCCAGTGGGACCTAACTTGGAGTGAGGACCTGCCCTCATGCCAGAGGGTGACTTCCTGCCACGATCCTGGAGATGTGGAGC
ACAGCCGACGCCTCATATCCAGCCCCAAGTTTCCCGTGGGGGCCACCGTGCAATATATCTGTGACCAGGGTTTTGTGCTGATGGGCAGCT
CCATCCTCACCTGCCATGATCGCCAGGCTGGCAGCCCCAAGTGGAGTGACCGGGCCCCTAAATGTCTCCTGGAACAGCTCAAGCCATGCC
ATGGTCTCAGTGCCCCTGAGAATGGTGCCCGAAGTCCTGAGAAGCAGCTACACCCAGCAGGGGCCACCATCCACTTCTCGTGTGCCCCTG
GCTATGTGCTGAAGGGCCAGGCCAGCATCAAGTGTGTGCCTGGGCACCCCTCGCATTGGAGTGACCCCCCACCCATCTGTAGGGCTGCCT
CTCTGGATGGGTTCTACAACAGTCGCAGCCTGGATGTTGCCAAGGCACCTGCTGCCTCCAGCACCCTGGATGCTGCCCACATTGCAGCTG
CCATCTTCTTGCCACTGGTGGCGATGGTGTTGTTGGTAGGAGGTGTATACTTCTACTTCTCCAGGCTCCAGGGAAAAAGCTCCCTGCAGC
TGCCCCGCCCCCGCCCCCGCCCCTACAACCGCATTACCATAGAGTCAGCGTTTGACAATCCAACTTACGAGACTGGAGAGACGAGAGAAT
ATGAAGTCTCCATCTAGGTGGGGGCAGTCTAGGGAAGTCAACTCAGACTTGCACCACAGTCCAGCAGCAAGGCTCCTTGCTTCCTGCTGT
CCCTCCACCTCCTGTATATACCACCTAGGAGGAGATGCCACCAAGCCCTCAAGAAGTTGTGCCCTTCCCCGCCTGCGATGCCCACCATGG
CCTATTTTCTTGGTGTCATTGCCCACTTGGGGCCCTTCATTGGGCCCATGTCAGGGGGCATCTACCTGTGGGAAGAACATAGCTGGAGCA
CAAGCATCAACAGCCAGCATCCTGAGCCTCCTCATGCCCTGGACCAGCCTGGAACACACTAGCAGAGCAGGAGTACCTTTCTCCACATGA
CCACCATCCCGCCCTGGCATGGCAACCTGCAGCAGGATTAACTTGACCATGGTGGGAACTGCACCAGGGTACTCCTCACAGCGCCATCAC
CAATGGCCAAAACTCCTCTCAACGGTGACCTCTGGGTAGTCCTGGCATGCCAACATCAGCCTCTTGGGAGGTCTCTAGTTCTCTAAAGTT
CTGGACAGTTCTGCCTCCTGCCCTGTCCCAGTGGAGGCAGTAATTCTAGGAGATCCTAAGGGGTTCAGGGGGACCCTACCCCCACCTCAG
GTTGGGCTTCCCTGGGCACTCATGCTCCACACCAAAGCAGGACACGCCATTTTCCACTGACCACCCTATACCCTGAGGAAAGGGAGACTT
TCCTCCGATGTTTATTTAGCTGTTGCAAACATCTTCACCCTAATAGTCCCTCCTCCAATTCCAGCCACTTGTCAGGCTCTCCTCTTGACC
ACTGTGTTATGGGATAAGGGGAGGGGGTGGGCATATTCTGGAGAGGAGCAGAGGTCCAAGGACCCAGGAATTTGGCATGGAACAGGTGGT
AGGAGAGCCCCAGGGAGACGCCCAGGAGCTGGCTGAAAGCCACTTTGTACATGTAATGTATTATATGGGGTCTGGGCTCCAGCCAGAGAA

>6278_6278_11_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000426542_SEZ6_chr17_27296970_ENST00000360295_length(amino acids)=718AA_BP=11
MELSCSEAPLYVQNISLREGETVTVEGLGGPDPLPLANQSFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLSCHFPRRPAY
GDVTVTSLHPGGSARFHCATGYQLKGARHLTCLNATQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRL
HLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSYEVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEPFVKYGNFSSS
TPTYPVGTTVEFSCDPGYTLEQGSIIIECVDPHDPQWNETEPACRAVCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDI
RVLRIGPGDVLTFYDGDDLTARVLGQYSGPRSHFKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCPELPEIPNGWKSPSQ
PELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHD
RQAGSPKWSDRAPKCLLEQLKPCHGLSAPENGARSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGHPSHWSDPPPICRAASLDGFYN

--------------------------------------------------------------
>6278_6278_12_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000426542_SEZ6_chr17_27296970_ENST00000442608_length(transcript)=2956nt_BP=53nt
TCATTGCAGATGCGAAAGCCATGGAGTTGAGCTGCAGCGAAGCACCTCTTTACGTCCAGAATATCAGCCTCCGGGAAGGGGAGACAGTGA
CTGTGGAAGGCCTGGGGGGGCCTGACCCACTGCCCCTGGCCAACCAGTCTTTCCTGCTGCGGGGCCAAGTCATCCGCAGCCCCACCCACC
AAGCGGCCCTGAGGTTCCAGAGCCTCCCGCCACCGGCTGGCCCTGGCACCTTCCATTTCCATTACCAAGCCTATCTCCTGAGCTGCCACT
TTCCCCGTCGTCCAGCTTATGGAGATGTGACTGTCACCAGCCTCCACCCAGGGGGTAGTGCCCGCTTCCATTGTGCCACTGGCTACCAGC
TGAAGGGCGCCAGGCATCTCACCTGTCTCAATGCCACCCAGCCCTTCTGGGATTCAAAGGAGCCCGTCTGCATCGCTGCTTGCGGCGGAG
TGATCCGCAATGCCACCACCGGCCGCATCGTCTCTCCAGGCTTCCCGGGCAACTACAGCAACAACCTCACCTGTCACTGGCTGCTTGAGG
CTCCTGAGGGCCAGCGGCTACACCTGCACTTTGAGAAGGTTTCCCTGGCAGAGGATGATGACAGGCTCATCATTCGCAATGGGGACAACG
TGGAGGCCCCACCAGTGTATGATTCCTATGAGGTGGAATACCTGCCCATTGAGGGCCTGCTCAGCTCTGGCAAACACTTCTTTGTTGAGC
TCAGTACTGACAGCAGCGGGGCAGCTGCAGGCATGGCCCTGCGCTATGAGGCCTTCCAGCAGGGCCATTGCTATGAGCCCTTTGTCAAAT
ACGGTAACTTCAGCAGCAGCACACCCACCTACCCTGTGGGTACCACTGTGGAGTTCAGCTGCGACCCTGGCTACACCCTGGAGCAGGGCT
CCATCATCATCGAGTGTGTTGACCCCCACGACCCCCAGTGGAATGAGACAGAGCCAGCCTGCCGAGCCGTGTGCAGCGGGGAGATCACAG
ACTCGGCTGGCGTGGTACTCTCTCCCAACTGGCCAGAGCCCTACGGTCGTGGGCAGGATTGTATCTGGGGTGTGCATGTGGAAGAGGACA
AGCGCATCATGCTGGACATCCGAGTGCTGCGCATAGGCCCTGGTGATGTGCTTACCTTCTATGATGGGGATGACCTGACGGCCCGGGTTC
TGGGCCAGTACTCAGGGCCCCGTAGCCACTTCAAGCTCTTTACCTCCATGGCTGATGTCACCATTCAGTTCCAGTCGGACCCCGGGACCT
CAGTGCTGGGCTACCAGCAGGGCTTCGTCATCCACTTCTTTGAGGTGCCCCGCAATGACACATGTCCGGAGCTGCCTGAGATCCCCAATG
GCTGGAAGAGCCCATCGCAGCCTGAGCTAGTGCACGGCACCGTGGTCACTTACCAGTGCTACCCTGGCTACCAGGTAGTGGGATCCAGTG
TCCTCATGTGCCAGTGGGACCTAACTTGGAGTGAGGACCTGCCCTCATGCCAGAGGGTGACTTCCTGCCACGATCCTGGAGATGTGGAGC
ACAGCCGACGCCTCATATCCAGCCCCAAGTTTCCCGTGGGGGCCACCGTGCAATATATCTGTGACCAGGGTTTTGTGCTGATGGGCAGCT
CCATCCTCACCTGCCATGATCGCCAGGCTGGCAGCCCCAAGTGGAGTGACCGGGCCCCTAAATGTCTCCTGGAACAGCTCAAGCCATGCC
ATGGTCTCAGTGCCCCTGAGAATGGTGCCCGAAGTCCTGAGAAGCAGCTACACCCAGCAGGGGCCACCATCCACTTCTCGTGTGCCCCTG
GCTATGTGCTGAAGGGCCAGGCCAGCATCAAGTGTGTGCCTGGGCACCCCTCGCATTGGAGTGACCCCCCACCCATCTGTAGGGCTGTTG
CCAAGGCACCTGCTGCCTCCAGCACCCTGGATGCTGCCCACATTGCAGCTGCCATCTTCTTGCCACTGGTGGCGATGGTGTTGTTGGTAG
GAGGTGTATACTTCTACTTCTCCAGGCTCCAGGGAAAAAGCTCCCTGCAGCTGCCCCGCCCCCGCCCCCGCCCCTACAACCGCATTACCA
TAGAGTCAGCGTTTGACAATCCAACTTACGAGACTGGAGAGACGAGAGAATATGAAGTCTCCATCTAGGTGGGGGCAGTCTAGGGAAGTC
AACTCAGACTTGCACCACAGTCCAGCAGCAAGGCTCCTTGCTTCCTGCTGTCCCTCCACCTCCTGTATATACCACCTAGGAGGAGATGCC
ACCAAGCCCTCAAGAAGTTGTGCCCTTCCCCGCCTGCGATGCCCACCATGGCCTATTTTCTTGGTGTCATTGCCCACTTGGGGCCCTTCA
TTGGGCCCATGTCAGGGGGCATCTACCTGTGGGAAGAACATAGCTGGAGCACAAGCATCAACAGCCAGCATCCTGAGCCTCCTCATGCCC
TGGACCAGCCTGGAACACACTAGCAGAGCAGGAGTACCTTTCTCCACATGACCACCATCCCGCCCTGGCATGGCAACCTGCAGCAGGATT
AACTTGACCATGGTGGGAACTGCACCAGGGTACTCCTCACAGCGCCATCACCAATGGCCAAAACTCCTCTCAACGGTGACCTCTGGGTAG
TCCTGGCATGCCAACATCAGCCTCTTGGGAGGTCTCTAGTTCTCTAAAGTTCTGGACAGTTCTGCCTCCTGCCCTGTCCCAGTGGAGGCA
GTAATTCTAGGAGATCCTAAGGGGTTCAGGGGGACCCTACCCCCACCTCAGGTTGGGCTTCCCTGGGCACTCATGCTCCACACCAAAGCA
GGACACGCCATTTTCCACTGACCACCCTATACCCTGAGGAAAGGGAGACTTTCCTCCGATGTTTATTTAGCTGTTGCAAACATCTTCACC

>6278_6278_12_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000426542_SEZ6_chr17_27296970_ENST00000442608_length(amino acids)=705AA_BP=11
MELSCSEAPLYVQNISLREGETVTVEGLGGPDPLPLANQSFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLSCHFPRRPAY
GDVTVTSLHPGGSARFHCATGYQLKGARHLTCLNATQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRL
HLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSYEVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEPFVKYGNFSSS
TPTYPVGTTVEFSCDPGYTLEQGSIIIECVDPHDPQWNETEPACRAVCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDI
RVLRIGPGDVLTFYDGDDLTARVLGQYSGPRSHFKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCPELPEIPNGWKSPSQ
PELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHD
RQAGSPKWSDRAPKCLLEQLKPCHGLSAPENGARSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGHPSHWSDPPPICRAVAKAPAAS

--------------------------------------------------------------
>6278_6278_13_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000437974_SEZ6_chr17_27296970_ENST00000317338_length(transcript)=3237nt_BP=53nt
TCATTGCAGATGCGAAAGCCATGGAGTTGAGCTGCAGCGAAGCACCTCTTTACGTCCAGAATATCAGCCTCCGGGAAGGGGAGACAGTGA
CTGTGGAAGGCCTGGGGGGGCCTGACCCACTGCCCCTGGCCAACCAGTCTTTCCTGCTGCGGGGCCAAGTCATCCGCAGCCCCACCCACC
AAGCGGCCCTGAGGTTCCAGAGCCTCCCGCCACCGGCTGGCCCTGGCACCTTCCATTTCCATTACCAAGCCTATCTCCTGAGCTGCCACT
TTCCCCGTCGTCCAGCTTATGGAGATGTGACTGTCACCAGCCTCCACCCAGGGGGTAGTGCCCGCTTCCATTGTGCCACTGGCTACCAGC
TGAAGGGCGCCAGGCATCTCACCTGTCTCAATGCCACCCAGCCCTTCTGGGATTCAAAGGAGCCCGTCTGCATCGCTGCTTGCGGCGGAG
TGATCCGCAATGCCACCACCGGCCGCATCGTCTCTCCAGGCTTCCCGGGCAACTACAGCAACAACCTCACCTGTCACTGGCTGCTTGAGG
CTCCTGAGGGCCAGCGGCTACACCTGCACTTTGAGAAGGTTTCCCTGGCAGAGGATGATGACAGGCTCATCATTCGCAATGGGGACAACG
TGGAGGCCCCACCAGTGTATGATTCCTATGAGGTGGAATACCTGCCCATTGAGGGCCTGCTCAGCTCTGGCAAACACTTCTTTGTTGAGC
TCAGTACTGACAGCAGCGGGGCAGCTGCAGGCATGGCCCTGCGCTATGAGGCCTTCCAGCAGGGCCATTGCTATGAGCCCTTTGTCAAAT
ACGGTAACTTCAGCAGCAGCACACCCACCTACCCTGTGGGTACCACTGTGGAGTTCAGCTGCGACCCTGGCTACACCCTGGAGCAGGGCT
CCATCATCATCGAGTGTGTTGACCCCCACGACCCCCAGTGGAATGAGACAGAGCCAGCCTGCCGAGCCGTGTGCAGCGGGGAGATCACAG
ACTCGGCTGGCGTGGTACTCTCTCCCAACTGGCCAGAGCCCTACGGTCGTGGGCAGGATTGTATCTGGGGTGTGCATGTGGAAGAGGACA
AGCGCATCATGCTGGACATCCGAGTGCTGCGCATAGGCCCTGGTGATGTGCTTACCTTCTATGATGGGGATGACCTGACGGCCCGGGTTC
TGGGCCAGTACTCAGGGCCCCGTAGCCACTTCAAGCTCTTTACCTCCATGGCTGATGTCACCATTCAGTTCCAGTCGGACCCCGGGACCT
CAGTGCTGGGCTACCAGCAGGGCTTCGTCATCCACTTCTTTGAGGTGCCCCGCAATGACACATGTCCGGAGCTGCCTGAGATCCCCAATG
GCTGGAAGAGCCCATCGCAGCCTGAGCTAGTGCACGGCACCGTGGTCACTTACCAGTGCTACCCTGGCTACCAGGTAGTGGGATCCAGTG
TCCTCATGTGCCAGTGGGACCTAACTTGGAGTGAGGACCTGCCCTCATGCCAGAGGGTGACTTCCTGCCACGATCCTGGAGATGTGGAGC
ACAGCCGACGCCTCATATCCAGCCCCAAGTTTCCCGTGGGGGCCACCGTGCAATATATCTGTGACCAGGGTTTTGTGCTGATGGGCAGCT
CCATCCTCACCTGCCATGATCGCCAGGCTGGCAGCCCCAAGTGGAGTGACCGGGCCCCTAAATGTCTCCTGGAACAGCTCAAGCCATGCC
ATGGTCTCAGTGCCCCTGAGAATGGTGCCCGAAGTCCTGAGAAGCAGCTACACCCAGCAGGGGCCACCATCCACTTCTCGTGTGCCCCTG
GCTATGTGCTGAAGGGCCAGGCCAGCATCAAGTGTGTGCCTGGGCACCCCTCGCATTGGAGTGACCCCCCACCCATCTGTAGGGCTGCCT
CTCTGGATGGGTTCTACAACAGTCGCAGCCTGGATGTTGCCAAGGCACCTGCTGCCTCCAGCACCCTGGATGCTGCCCACATTGCAGCTG
CCATCTTCTTGCCACTGGTGGCGATGGTGTTGTTGGTAGGAGGTGTATACTTCTACTTCTCCAGGCTCCAGGGAAAAAGCTCCCTGCAGC
TGCCCCGCCCCCGCCCCCGCCCCTACAACCGCATTACCATAGAGTCAGCGTTTGACAATCCAACTTACGAGACTGGATCTCTTTCCTTTG
CAGGAGACGAGAGAATATGAAGTCTCCATCTAGGTGGGGGCAGTCTAGGGAAGTCAACTCAGACTTGCACCACAGTCCAGCAGCAAGGCT
CCTTGCTTCCTGCTGTCCCTCCACCTCCTGTATATACCACCTAGGAGGAGATGCCACCAAGCCCTCAAGAAGTTGTGCCCTTCCCCGCCT
GCGATGCCCACCATGGCCTATTTTCTTGGTGTCATTGCCCACTTGGGGCCCTTCATTGGGCCCATGTCAGGGGGCATCTACCTGTGGGAA
GAACATAGCTGGAGCACAAGCATCAACAGCCAGCATCCTGAGCCTCCTCATGCCCTGGACCAGCCTGGAACACACTAGCAGAGCAGGAGT
ACCTTTCTCCACATGACCACCATCCCGCCCTGGCATGGCAACCTGCAGCAGGATTAACTTGACCATGGTGGGAACTGCACCAGGGTACTC
CTCACAGCGCCATCACCAATGGCCAAAACTCCTCTCAACGGTGACCTCTGGGTAGTCCTGGCATGCCAACATCAGCCTCTTGGGAGGTCT
CTAGTTCTCTAAAGTTCTGGACAGTTCTGCCTCCTGCCCTGTCCCAGTGGAGGCAGTAATTCTAGGAGATCCTAAGGGGTTCAGGGGGAC
CCTACCCCCACCTCAGGTTGGGCTTCCCTGGGCACTCATGCTCCACACCAAAGCAGGACACGCCATTTTCCACTGACCACCCTATACCCT
GAGGAAAGGGAGACTTTCCTCCGATGTTTATTTAGCTGTTGCAAACATCTTCACCCTAATAGTCCCTCCTCCAATTCCAGCCACTTGTCA
GGCTCTCCTCTTGACCACTGTGTTATGGGATAAGGGGAGGGGGTGGGCATATTCTGGAGAGGAGCAGAGGTCCAAGGACCCAGGAATTTG
GCATGGAACAGGTGGTAGGAGAGCCCCAGGGAGACGCCCAGGAGCTGGCTGAAAGCCACTTTGTACATGTAATGTATTATATGGGGTCTG

>6278_6278_13_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000437974_SEZ6_chr17_27296970_ENST00000317338_length(amino acids)=719AA_BP=11
MELSCSEAPLYVQNISLREGETVTVEGLGGPDPLPLANQSFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLSCHFPRRPAY
GDVTVTSLHPGGSARFHCATGYQLKGARHLTCLNATQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRL
HLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSYEVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEPFVKYGNFSSS
TPTYPVGTTVEFSCDPGYTLEQGSIIIECVDPHDPQWNETEPACRAVCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDI
RVLRIGPGDVLTFYDGDDLTARVLGQYSGPRSHFKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCPELPEIPNGWKSPSQ
PELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHD
RQAGSPKWSDRAPKCLLEQLKPCHGLSAPENGARSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGHPSHWSDPPPICRAASLDGFYN

--------------------------------------------------------------
>6278_6278_14_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000437974_SEZ6_chr17_27296970_ENST00000335960_length(transcript)=722nt_BP=53nt
TCATTGCAGATGCGAAAGCCATGGAGTTGAGCTGCAGCGAAGCACCTCTTTACGTCCAGAATATCAGCCTCCGGGAAGGGGAGACAGTGA
CTGTGGAAGGCCTGGGGGGGCCTGACCCACTGCCCCTGGCCAACCAGTCTTTCCTGCTGCGGGGCCAAGTCATCCGCAGCCCCACCCACC
AAGCGGCCCTGAGGTTCCAGAGCCTCCCGCCACCGGCTGGCCCTGGCACCTTCCATTTCCATTACCAAGCCTATCTCCTGAGCTGCCACT
TTCCCCGTCGTCCAGCTTATGGAGATGTGACTGTCACCAGCCTCCACCCAGGGGGTAGTGCCCGCTTCCATTGTGCCACTGGCTACCAGC
TGAAGGGCGCCAGGCATCTCACCTGTCTCAATGCCACCCAGCCCTTCTGGGATTCAAAGGAGCCCGTCTGCATCGCTGCTTGCGGCGGAG
TGATCCGCAATGCCACCACCGGCCGCATCGTCTCTCCAGGCTTCCCGGGCAACTACAGCAACAACCTCACCTGTCACTGGCTGCTTGAGG
CTCCTGAGGGCCAGCGGCTACACCTGCACTTTGAGAAGGTTTCCCTGGCAGAGGATGATGACAGGCTCATCATTCGCAATGGGGACAACG
TGGAGGCCCCACCAGTGTATGATTCCTATGAGGTGACTGCCCCGCCCCCGCCCCCGCCCCTACAACCGCATTACCATAGAGTCAGCGTTT

>6278_6278_14_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000437974_SEZ6_chr17_27296970_ENST00000335960_length(amino acids)=234AA_BP=11
MELSCSEAPLYVQNISLREGETVTVEGLGGPDPLPLANQSFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLSCHFPRRPAY
GDVTVTSLHPGGSARFHCATGYQLKGARHLTCLNATQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRL

--------------------------------------------------------------
>6278_6278_15_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000437974_SEZ6_chr17_27296970_ENST00000360295_length(transcript)=3225nt_BP=53nt
TCATTGCAGATGCGAAAGCCATGGAGTTGAGCTGCAGCGAAGCACCTCTTTACGTCCAGAATATCAGCCTCCGGGAAGGGGAGACAGTGA
CTGTGGAAGGCCTGGGGGGGCCTGACCCACTGCCCCTGGCCAACCAGTCTTTCCTGCTGCGGGGCCAAGTCATCCGCAGCCCCACCCACC
AAGCGGCCCTGAGGTTCCAGAGCCTCCCGCCACCGGCTGGCCCTGGCACCTTCCATTTCCATTACCAAGCCTATCTCCTGAGCTGCCACT
TTCCCCGTCGTCCAGCTTATGGAGATGTGACTGTCACCAGCCTCCACCCAGGGGGTAGTGCCCGCTTCCATTGTGCCACTGGCTACCAGC
TGAAGGGCGCCAGGCATCTCACCTGTCTCAATGCCACCCAGCCCTTCTGGGATTCAAAGGAGCCCGTCTGCATCGCTGCTTGCGGCGGAG
TGATCCGCAATGCCACCACCGGCCGCATCGTCTCTCCAGGCTTCCCGGGCAACTACAGCAACAACCTCACCTGTCACTGGCTGCTTGAGG
CTCCTGAGGGCCAGCGGCTACACCTGCACTTTGAGAAGGTTTCCCTGGCAGAGGATGATGACAGGCTCATCATTCGCAATGGGGACAACG
TGGAGGCCCCACCAGTGTATGATTCCTATGAGGTGGAATACCTGCCCATTGAGGGCCTGCTCAGCTCTGGCAAACACTTCTTTGTTGAGC
TCAGTACTGACAGCAGCGGGGCAGCTGCAGGCATGGCCCTGCGCTATGAGGCCTTCCAGCAGGGCCATTGCTATGAGCCCTTTGTCAAAT
ACGGTAACTTCAGCAGCAGCACACCCACCTACCCTGTGGGTACCACTGTGGAGTTCAGCTGCGACCCTGGCTACACCCTGGAGCAGGGCT
CCATCATCATCGAGTGTGTTGACCCCCACGACCCCCAGTGGAATGAGACAGAGCCAGCCTGCCGAGCCGTGTGCAGCGGGGAGATCACAG
ACTCGGCTGGCGTGGTACTCTCTCCCAACTGGCCAGAGCCCTACGGTCGTGGGCAGGATTGTATCTGGGGTGTGCATGTGGAAGAGGACA
AGCGCATCATGCTGGACATCCGAGTGCTGCGCATAGGCCCTGGTGATGTGCTTACCTTCTATGATGGGGATGACCTGACGGCCCGGGTTC
TGGGCCAGTACTCAGGGCCCCGTAGCCACTTCAAGCTCTTTACCTCCATGGCTGATGTCACCATTCAGTTCCAGTCGGACCCCGGGACCT
CAGTGCTGGGCTACCAGCAGGGCTTCGTCATCCACTTCTTTGAGGTGCCCCGCAATGACACATGTCCGGAGCTGCCTGAGATCCCCAATG
GCTGGAAGAGCCCATCGCAGCCTGAGCTAGTGCACGGCACCGTGGTCACTTACCAGTGCTACCCTGGCTACCAGGTAGTGGGATCCAGTG
TCCTCATGTGCCAGTGGGACCTAACTTGGAGTGAGGACCTGCCCTCATGCCAGAGGGTGACTTCCTGCCACGATCCTGGAGATGTGGAGC
ACAGCCGACGCCTCATATCCAGCCCCAAGTTTCCCGTGGGGGCCACCGTGCAATATATCTGTGACCAGGGTTTTGTGCTGATGGGCAGCT
CCATCCTCACCTGCCATGATCGCCAGGCTGGCAGCCCCAAGTGGAGTGACCGGGCCCCTAAATGTCTCCTGGAACAGCTCAAGCCATGCC
ATGGTCTCAGTGCCCCTGAGAATGGTGCCCGAAGTCCTGAGAAGCAGCTACACCCAGCAGGGGCCACCATCCACTTCTCGTGTGCCCCTG
GCTATGTGCTGAAGGGCCAGGCCAGCATCAAGTGTGTGCCTGGGCACCCCTCGCATTGGAGTGACCCCCCACCCATCTGTAGGGCTGCCT
CTCTGGATGGGTTCTACAACAGTCGCAGCCTGGATGTTGCCAAGGCACCTGCTGCCTCCAGCACCCTGGATGCTGCCCACATTGCAGCTG
CCATCTTCTTGCCACTGGTGGCGATGGTGTTGTTGGTAGGAGGTGTATACTTCTACTTCTCCAGGCTCCAGGGAAAAAGCTCCCTGCAGC
TGCCCCGCCCCCGCCCCCGCCCCTACAACCGCATTACCATAGAGTCAGCGTTTGACAATCCAACTTACGAGACTGGAGAGACGAGAGAAT
ATGAAGTCTCCATCTAGGTGGGGGCAGTCTAGGGAAGTCAACTCAGACTTGCACCACAGTCCAGCAGCAAGGCTCCTTGCTTCCTGCTGT
CCCTCCACCTCCTGTATATACCACCTAGGAGGAGATGCCACCAAGCCCTCAAGAAGTTGTGCCCTTCCCCGCCTGCGATGCCCACCATGG
CCTATTTTCTTGGTGTCATTGCCCACTTGGGGCCCTTCATTGGGCCCATGTCAGGGGGCATCTACCTGTGGGAAGAACATAGCTGGAGCA
CAAGCATCAACAGCCAGCATCCTGAGCCTCCTCATGCCCTGGACCAGCCTGGAACACACTAGCAGAGCAGGAGTACCTTTCTCCACATGA
CCACCATCCCGCCCTGGCATGGCAACCTGCAGCAGGATTAACTTGACCATGGTGGGAACTGCACCAGGGTACTCCTCACAGCGCCATCAC
CAATGGCCAAAACTCCTCTCAACGGTGACCTCTGGGTAGTCCTGGCATGCCAACATCAGCCTCTTGGGAGGTCTCTAGTTCTCTAAAGTT
CTGGACAGTTCTGCCTCCTGCCCTGTCCCAGTGGAGGCAGTAATTCTAGGAGATCCTAAGGGGTTCAGGGGGACCCTACCCCCACCTCAG
GTTGGGCTTCCCTGGGCACTCATGCTCCACACCAAAGCAGGACACGCCATTTTCCACTGACCACCCTATACCCTGAGGAAAGGGAGACTT
TCCTCCGATGTTTATTTAGCTGTTGCAAACATCTTCACCCTAATAGTCCCTCCTCCAATTCCAGCCACTTGTCAGGCTCTCCTCTTGACC
ACTGTGTTATGGGATAAGGGGAGGGGGTGGGCATATTCTGGAGAGGAGCAGAGGTCCAAGGACCCAGGAATTTGGCATGGAACAGGTGGT
AGGAGAGCCCCAGGGAGACGCCCAGGAGCTGGCTGAAAGCCACTTTGTACATGTAATGTATTATATGGGGTCTGGGCTCCAGCCAGAGAA

>6278_6278_15_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000437974_SEZ6_chr17_27296970_ENST00000360295_length(amino acids)=718AA_BP=11
MELSCSEAPLYVQNISLREGETVTVEGLGGPDPLPLANQSFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLSCHFPRRPAY
GDVTVTSLHPGGSARFHCATGYQLKGARHLTCLNATQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRL
HLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSYEVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEPFVKYGNFSSS
TPTYPVGTTVEFSCDPGYTLEQGSIIIECVDPHDPQWNETEPACRAVCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDI
RVLRIGPGDVLTFYDGDDLTARVLGQYSGPRSHFKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCPELPEIPNGWKSPSQ
PELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHD
RQAGSPKWSDRAPKCLLEQLKPCHGLSAPENGARSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGHPSHWSDPPPICRAASLDGFYN

--------------------------------------------------------------
>6278_6278_16_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000437974_SEZ6_chr17_27296970_ENST00000442608_length(transcript)=2956nt_BP=53nt
TCATTGCAGATGCGAAAGCCATGGAGTTGAGCTGCAGCGAAGCACCTCTTTACGTCCAGAATATCAGCCTCCGGGAAGGGGAGACAGTGA
CTGTGGAAGGCCTGGGGGGGCCTGACCCACTGCCCCTGGCCAACCAGTCTTTCCTGCTGCGGGGCCAAGTCATCCGCAGCCCCACCCACC
AAGCGGCCCTGAGGTTCCAGAGCCTCCCGCCACCGGCTGGCCCTGGCACCTTCCATTTCCATTACCAAGCCTATCTCCTGAGCTGCCACT
TTCCCCGTCGTCCAGCTTATGGAGATGTGACTGTCACCAGCCTCCACCCAGGGGGTAGTGCCCGCTTCCATTGTGCCACTGGCTACCAGC
TGAAGGGCGCCAGGCATCTCACCTGTCTCAATGCCACCCAGCCCTTCTGGGATTCAAAGGAGCCCGTCTGCATCGCTGCTTGCGGCGGAG
TGATCCGCAATGCCACCACCGGCCGCATCGTCTCTCCAGGCTTCCCGGGCAACTACAGCAACAACCTCACCTGTCACTGGCTGCTTGAGG
CTCCTGAGGGCCAGCGGCTACACCTGCACTTTGAGAAGGTTTCCCTGGCAGAGGATGATGACAGGCTCATCATTCGCAATGGGGACAACG
TGGAGGCCCCACCAGTGTATGATTCCTATGAGGTGGAATACCTGCCCATTGAGGGCCTGCTCAGCTCTGGCAAACACTTCTTTGTTGAGC
TCAGTACTGACAGCAGCGGGGCAGCTGCAGGCATGGCCCTGCGCTATGAGGCCTTCCAGCAGGGCCATTGCTATGAGCCCTTTGTCAAAT
ACGGTAACTTCAGCAGCAGCACACCCACCTACCCTGTGGGTACCACTGTGGAGTTCAGCTGCGACCCTGGCTACACCCTGGAGCAGGGCT
CCATCATCATCGAGTGTGTTGACCCCCACGACCCCCAGTGGAATGAGACAGAGCCAGCCTGCCGAGCCGTGTGCAGCGGGGAGATCACAG
ACTCGGCTGGCGTGGTACTCTCTCCCAACTGGCCAGAGCCCTACGGTCGTGGGCAGGATTGTATCTGGGGTGTGCATGTGGAAGAGGACA
AGCGCATCATGCTGGACATCCGAGTGCTGCGCATAGGCCCTGGTGATGTGCTTACCTTCTATGATGGGGATGACCTGACGGCCCGGGTTC
TGGGCCAGTACTCAGGGCCCCGTAGCCACTTCAAGCTCTTTACCTCCATGGCTGATGTCACCATTCAGTTCCAGTCGGACCCCGGGACCT
CAGTGCTGGGCTACCAGCAGGGCTTCGTCATCCACTTCTTTGAGGTGCCCCGCAATGACACATGTCCGGAGCTGCCTGAGATCCCCAATG
GCTGGAAGAGCCCATCGCAGCCTGAGCTAGTGCACGGCACCGTGGTCACTTACCAGTGCTACCCTGGCTACCAGGTAGTGGGATCCAGTG
TCCTCATGTGCCAGTGGGACCTAACTTGGAGTGAGGACCTGCCCTCATGCCAGAGGGTGACTTCCTGCCACGATCCTGGAGATGTGGAGC
ACAGCCGACGCCTCATATCCAGCCCCAAGTTTCCCGTGGGGGCCACCGTGCAATATATCTGTGACCAGGGTTTTGTGCTGATGGGCAGCT
CCATCCTCACCTGCCATGATCGCCAGGCTGGCAGCCCCAAGTGGAGTGACCGGGCCCCTAAATGTCTCCTGGAACAGCTCAAGCCATGCC
ATGGTCTCAGTGCCCCTGAGAATGGTGCCCGAAGTCCTGAGAAGCAGCTACACCCAGCAGGGGCCACCATCCACTTCTCGTGTGCCCCTG
GCTATGTGCTGAAGGGCCAGGCCAGCATCAAGTGTGTGCCTGGGCACCCCTCGCATTGGAGTGACCCCCCACCCATCTGTAGGGCTGTTG
CCAAGGCACCTGCTGCCTCCAGCACCCTGGATGCTGCCCACATTGCAGCTGCCATCTTCTTGCCACTGGTGGCGATGGTGTTGTTGGTAG
GAGGTGTATACTTCTACTTCTCCAGGCTCCAGGGAAAAAGCTCCCTGCAGCTGCCCCGCCCCCGCCCCCGCCCCTACAACCGCATTACCA
TAGAGTCAGCGTTTGACAATCCAACTTACGAGACTGGAGAGACGAGAGAATATGAAGTCTCCATCTAGGTGGGGGCAGTCTAGGGAAGTC
AACTCAGACTTGCACCACAGTCCAGCAGCAAGGCTCCTTGCTTCCTGCTGTCCCTCCACCTCCTGTATATACCACCTAGGAGGAGATGCC
ACCAAGCCCTCAAGAAGTTGTGCCCTTCCCCGCCTGCGATGCCCACCATGGCCTATTTTCTTGGTGTCATTGCCCACTTGGGGCCCTTCA
TTGGGCCCATGTCAGGGGGCATCTACCTGTGGGAAGAACATAGCTGGAGCACAAGCATCAACAGCCAGCATCCTGAGCCTCCTCATGCCC
TGGACCAGCCTGGAACACACTAGCAGAGCAGGAGTACCTTTCTCCACATGACCACCATCCCGCCCTGGCATGGCAACCTGCAGCAGGATT
AACTTGACCATGGTGGGAACTGCACCAGGGTACTCCTCACAGCGCCATCACCAATGGCCAAAACTCCTCTCAACGGTGACCTCTGGGTAG
TCCTGGCATGCCAACATCAGCCTCTTGGGAGGTCTCTAGTTCTCTAAAGTTCTGGACAGTTCTGCCTCCTGCCCTGTCCCAGTGGAGGCA
GTAATTCTAGGAGATCCTAAGGGGTTCAGGGGGACCCTACCCCCACCTCAGGTTGGGCTTCCCTGGGCACTCATGCTCCACACCAAAGCA
GGACACGCCATTTTCCACTGACCACCCTATACCCTGAGGAAAGGGAGACTTTCCTCCGATGTTTATTTAGCTGTTGCAAACATCTTCACC

>6278_6278_16_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000437974_SEZ6_chr17_27296970_ENST00000442608_length(amino acids)=705AA_BP=11
MELSCSEAPLYVQNISLREGETVTVEGLGGPDPLPLANQSFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLSCHFPRRPAY
GDVTVTSLHPGGSARFHCATGYQLKGARHLTCLNATQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRL
HLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSYEVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEPFVKYGNFSSS
TPTYPVGTTVEFSCDPGYTLEQGSIIIECVDPHDPQWNETEPACRAVCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDI
RVLRIGPGDVLTFYDGDDLTARVLGQYSGPRSHFKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCPELPEIPNGWKSPSQ
PELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHD
RQAGSPKWSDRAPKCLLEQLKPCHGLSAPENGARSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGHPSHWSDPPPICRAVAKAPAAS

--------------------------------------------------------------
>6278_6278_17_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000513042_SEZ6_chr17_27296970_ENST00000317338_length(transcript)=3393nt_BP=209nt
AAACCTTGGCTTCAGCCCGGCCGCCGCCAGGCGTTGGCATCGCCGGGGAGAGCCTTCCGGACTCCGGGCGGCGGCTGGCTGGGGGCGCGT
TCCGAGGCGCCCTCAGGCAGGGCGCGGGGGCAGAGCCTCGCCTGGGTTCTGGAGGCTGCGGGGCCATCGCTCCAGATGCGAAAGCCATGG
AGTTGAGCTGCAGCGAAGCACCTCTTTACGTCCAGAATATCAGCCTCCGGGAAGGGGAGACAGTGACTGTGGAAGGCCTGGGGGGGCCTG
ACCCACTGCCCCTGGCCAACCAGTCTTTCCTGCTGCGGGGCCAAGTCATCCGCAGCCCCACCCACCAAGCGGCCCTGAGGTTCCAGAGCC
TCCCGCCACCGGCTGGCCCTGGCACCTTCCATTTCCATTACCAAGCCTATCTCCTGAGCTGCCACTTTCCCCGTCGTCCAGCTTATGGAG
ATGTGACTGTCACCAGCCTCCACCCAGGGGGTAGTGCCCGCTTCCATTGTGCCACTGGCTACCAGCTGAAGGGCGCCAGGCATCTCACCT
GTCTCAATGCCACCCAGCCCTTCTGGGATTCAAAGGAGCCCGTCTGCATCGCTGCTTGCGGCGGAGTGATCCGCAATGCCACCACCGGCC
GCATCGTCTCTCCAGGCTTCCCGGGCAACTACAGCAACAACCTCACCTGTCACTGGCTGCTTGAGGCTCCTGAGGGCCAGCGGCTACACC
TGCACTTTGAGAAGGTTTCCCTGGCAGAGGATGATGACAGGCTCATCATTCGCAATGGGGACAACGTGGAGGCCCCACCAGTGTATGATT
CCTATGAGGTGGAATACCTGCCCATTGAGGGCCTGCTCAGCTCTGGCAAACACTTCTTTGTTGAGCTCAGTACTGACAGCAGCGGGGCAG
CTGCAGGCATGGCCCTGCGCTATGAGGCCTTCCAGCAGGGCCATTGCTATGAGCCCTTTGTCAAATACGGTAACTTCAGCAGCAGCACAC
CCACCTACCCTGTGGGTACCACTGTGGAGTTCAGCTGCGACCCTGGCTACACCCTGGAGCAGGGCTCCATCATCATCGAGTGTGTTGACC
CCCACGACCCCCAGTGGAATGAGACAGAGCCAGCCTGCCGAGCCGTGTGCAGCGGGGAGATCACAGACTCGGCTGGCGTGGTACTCTCTC
CCAACTGGCCAGAGCCCTACGGTCGTGGGCAGGATTGTATCTGGGGTGTGCATGTGGAAGAGGACAAGCGCATCATGCTGGACATCCGAG
TGCTGCGCATAGGCCCTGGTGATGTGCTTACCTTCTATGATGGGGATGACCTGACGGCCCGGGTTCTGGGCCAGTACTCAGGGCCCCGTA
GCCACTTCAAGCTCTTTACCTCCATGGCTGATGTCACCATTCAGTTCCAGTCGGACCCCGGGACCTCAGTGCTGGGCTACCAGCAGGGCT
TCGTCATCCACTTCTTTGAGGTGCCCCGCAATGACACATGTCCGGAGCTGCCTGAGATCCCCAATGGCTGGAAGAGCCCATCGCAGCCTG
AGCTAGTGCACGGCACCGTGGTCACTTACCAGTGCTACCCTGGCTACCAGGTAGTGGGATCCAGTGTCCTCATGTGCCAGTGGGACCTAA
CTTGGAGTGAGGACCTGCCCTCATGCCAGAGGGTGACTTCCTGCCACGATCCTGGAGATGTGGAGCACAGCCGACGCCTCATATCCAGCC
CCAAGTTTCCCGTGGGGGCCACCGTGCAATATATCTGTGACCAGGGTTTTGTGCTGATGGGCAGCTCCATCCTCACCTGCCATGATCGCC
AGGCTGGCAGCCCCAAGTGGAGTGACCGGGCCCCTAAATGTCTCCTGGAACAGCTCAAGCCATGCCATGGTCTCAGTGCCCCTGAGAATG
GTGCCCGAAGTCCTGAGAAGCAGCTACACCCAGCAGGGGCCACCATCCACTTCTCGTGTGCCCCTGGCTATGTGCTGAAGGGCCAGGCCA
GCATCAAGTGTGTGCCTGGGCACCCCTCGCATTGGAGTGACCCCCCACCCATCTGTAGGGCTGCCTCTCTGGATGGGTTCTACAACAGTC
GCAGCCTGGATGTTGCCAAGGCACCTGCTGCCTCCAGCACCCTGGATGCTGCCCACATTGCAGCTGCCATCTTCTTGCCACTGGTGGCGA
TGGTGTTGTTGGTAGGAGGTGTATACTTCTACTTCTCCAGGCTCCAGGGAAAAAGCTCCCTGCAGCTGCCCCGCCCCCGCCCCCGCCCCT
ACAACCGCATTACCATAGAGTCAGCGTTTGACAATCCAACTTACGAGACTGGATCTCTTTCCTTTGCAGGAGACGAGAGAATATGAAGTC
TCCATCTAGGTGGGGGCAGTCTAGGGAAGTCAACTCAGACTTGCACCACAGTCCAGCAGCAAGGCTCCTTGCTTCCTGCTGTCCCTCCAC
CTCCTGTATATACCACCTAGGAGGAGATGCCACCAAGCCCTCAAGAAGTTGTGCCCTTCCCCGCCTGCGATGCCCACCATGGCCTATTTT
CTTGGTGTCATTGCCCACTTGGGGCCCTTCATTGGGCCCATGTCAGGGGGCATCTACCTGTGGGAAGAACATAGCTGGAGCACAAGCATC
AACAGCCAGCATCCTGAGCCTCCTCATGCCCTGGACCAGCCTGGAACACACTAGCAGAGCAGGAGTACCTTTCTCCACATGACCACCATC
CCGCCCTGGCATGGCAACCTGCAGCAGGATTAACTTGACCATGGTGGGAACTGCACCAGGGTACTCCTCACAGCGCCATCACCAATGGCC
AAAACTCCTCTCAACGGTGACCTCTGGGTAGTCCTGGCATGCCAACATCAGCCTCTTGGGAGGTCTCTAGTTCTCTAAAGTTCTGGACAG
TTCTGCCTCCTGCCCTGTCCCAGTGGAGGCAGTAATTCTAGGAGATCCTAAGGGGTTCAGGGGGACCCTACCCCCACCTCAGGTTGGGCT
TCCCTGGGCACTCATGCTCCACACCAAAGCAGGACACGCCATTTTCCACTGACCACCCTATACCCTGAGGAAAGGGAGACTTTCCTCCGA
TGTTTATTTAGCTGTTGCAAACATCTTCACCCTAATAGTCCCTCCTCCAATTCCAGCCACTTGTCAGGCTCTCCTCTTGACCACTGTGTT
ATGGGATAAGGGGAGGGGGTGGGCATATTCTGGAGAGGAGCAGAGGTCCAAGGACCCAGGAATTTGGCATGGAACAGGTGGTAGGAGAGC
CCCAGGGAGACGCCCAGGAGCTGGCTGAAAGCCACTTTGTACATGTAATGTATTATATGGGGTCTGGGCTCCAGCCAGAGAACAATCTTT

>6278_6278_17_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000513042_SEZ6_chr17_27296970_ENST00000317338_length(amino acids)=776AA_BP=68
MASARPPPGVGIAGESLPDSGRRLAGGAFRGALRQGAGAEPRLGSGGCGAIAPDAKAMELSCSEAPLYVQNISLREGETVTVEGLGGPDP
LPLANQSFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLSCHFPRRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCL
NATQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSY
EVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEPFVKYGNFSSSTPTYPVGTTVEFSCDPGYTLEQGSIIIECVDPH
DPQWNETEPACRAVCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPGDVLTFYDGDDLTARVLGQYSGPRSH
FKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTW
SEDLPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHDRQAGSPKWSDRAPKCLLEQLKPCHGLSAPENGA
RSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGHPSHWSDPPPICRAASLDGFYNSRSLDVAKAPAASSTLDAAHIAAAIFLPLVAMV

--------------------------------------------------------------
>6278_6278_18_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000513042_SEZ6_chr17_27296970_ENST00000335960_length(transcript)=878nt_BP=209nt
AAACCTTGGCTTCAGCCCGGCCGCCGCCAGGCGTTGGCATCGCCGGGGAGAGCCTTCCGGACTCCGGGCGGCGGCTGGCTGGGGGCGCGT
TCCGAGGCGCCCTCAGGCAGGGCGCGGGGGCAGAGCCTCGCCTGGGTTCTGGAGGCTGCGGGGCCATCGCTCCAGATGCGAAAGCCATGG
AGTTGAGCTGCAGCGAAGCACCTCTTTACGTCCAGAATATCAGCCTCCGGGAAGGGGAGACAGTGACTGTGGAAGGCCTGGGGGGGCCTG
ACCCACTGCCCCTGGCCAACCAGTCTTTCCTGCTGCGGGGCCAAGTCATCCGCAGCCCCACCCACCAAGCGGCCCTGAGGTTCCAGAGCC
TCCCGCCACCGGCTGGCCCTGGCACCTTCCATTTCCATTACCAAGCCTATCTCCTGAGCTGCCACTTTCCCCGTCGTCCAGCTTATGGAG
ATGTGACTGTCACCAGCCTCCACCCAGGGGGTAGTGCCCGCTTCCATTGTGCCACTGGCTACCAGCTGAAGGGCGCCAGGCATCTCACCT
GTCTCAATGCCACCCAGCCCTTCTGGGATTCAAAGGAGCCCGTCTGCATCGCTGCTTGCGGCGGAGTGATCCGCAATGCCACCACCGGCC
GCATCGTCTCTCCAGGCTTCCCGGGCAACTACAGCAACAACCTCACCTGTCACTGGCTGCTTGAGGCTCCTGAGGGCCAGCGGCTACACC
TGCACTTTGAGAAGGTTTCCCTGGCAGAGGATGATGACAGGCTCATCATTCGCAATGGGGACAACGTGGAGGCCCCACCAGTGTATGATT

>6278_6278_18_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000513042_SEZ6_chr17_27296970_ENST00000335960_length(amino acids)=291AA_BP=68
MASARPPPGVGIAGESLPDSGRRLAGGAFRGALRQGAGAEPRLGSGGCGAIAPDAKAMELSCSEAPLYVQNISLREGETVTVEGLGGPDP
LPLANQSFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLSCHFPRRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCL
NATQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSY

--------------------------------------------------------------
>6278_6278_19_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000513042_SEZ6_chr17_27296970_ENST00000360295_length(transcript)=3381nt_BP=209nt
AAACCTTGGCTTCAGCCCGGCCGCCGCCAGGCGTTGGCATCGCCGGGGAGAGCCTTCCGGACTCCGGGCGGCGGCTGGCTGGGGGCGCGT
TCCGAGGCGCCCTCAGGCAGGGCGCGGGGGCAGAGCCTCGCCTGGGTTCTGGAGGCTGCGGGGCCATCGCTCCAGATGCGAAAGCCATGG
AGTTGAGCTGCAGCGAAGCACCTCTTTACGTCCAGAATATCAGCCTCCGGGAAGGGGAGACAGTGACTGTGGAAGGCCTGGGGGGGCCTG
ACCCACTGCCCCTGGCCAACCAGTCTTTCCTGCTGCGGGGCCAAGTCATCCGCAGCCCCACCCACCAAGCGGCCCTGAGGTTCCAGAGCC
TCCCGCCACCGGCTGGCCCTGGCACCTTCCATTTCCATTACCAAGCCTATCTCCTGAGCTGCCACTTTCCCCGTCGTCCAGCTTATGGAG
ATGTGACTGTCACCAGCCTCCACCCAGGGGGTAGTGCCCGCTTCCATTGTGCCACTGGCTACCAGCTGAAGGGCGCCAGGCATCTCACCT
GTCTCAATGCCACCCAGCCCTTCTGGGATTCAAAGGAGCCCGTCTGCATCGCTGCTTGCGGCGGAGTGATCCGCAATGCCACCACCGGCC
GCATCGTCTCTCCAGGCTTCCCGGGCAACTACAGCAACAACCTCACCTGTCACTGGCTGCTTGAGGCTCCTGAGGGCCAGCGGCTACACC
TGCACTTTGAGAAGGTTTCCCTGGCAGAGGATGATGACAGGCTCATCATTCGCAATGGGGACAACGTGGAGGCCCCACCAGTGTATGATT
CCTATGAGGTGGAATACCTGCCCATTGAGGGCCTGCTCAGCTCTGGCAAACACTTCTTTGTTGAGCTCAGTACTGACAGCAGCGGGGCAG
CTGCAGGCATGGCCCTGCGCTATGAGGCCTTCCAGCAGGGCCATTGCTATGAGCCCTTTGTCAAATACGGTAACTTCAGCAGCAGCACAC
CCACCTACCCTGTGGGTACCACTGTGGAGTTCAGCTGCGACCCTGGCTACACCCTGGAGCAGGGCTCCATCATCATCGAGTGTGTTGACC
CCCACGACCCCCAGTGGAATGAGACAGAGCCAGCCTGCCGAGCCGTGTGCAGCGGGGAGATCACAGACTCGGCTGGCGTGGTACTCTCTC
CCAACTGGCCAGAGCCCTACGGTCGTGGGCAGGATTGTATCTGGGGTGTGCATGTGGAAGAGGACAAGCGCATCATGCTGGACATCCGAG
TGCTGCGCATAGGCCCTGGTGATGTGCTTACCTTCTATGATGGGGATGACCTGACGGCCCGGGTTCTGGGCCAGTACTCAGGGCCCCGTA
GCCACTTCAAGCTCTTTACCTCCATGGCTGATGTCACCATTCAGTTCCAGTCGGACCCCGGGACCTCAGTGCTGGGCTACCAGCAGGGCT
TCGTCATCCACTTCTTTGAGGTGCCCCGCAATGACACATGTCCGGAGCTGCCTGAGATCCCCAATGGCTGGAAGAGCCCATCGCAGCCTG
AGCTAGTGCACGGCACCGTGGTCACTTACCAGTGCTACCCTGGCTACCAGGTAGTGGGATCCAGTGTCCTCATGTGCCAGTGGGACCTAA
CTTGGAGTGAGGACCTGCCCTCATGCCAGAGGGTGACTTCCTGCCACGATCCTGGAGATGTGGAGCACAGCCGACGCCTCATATCCAGCC
CCAAGTTTCCCGTGGGGGCCACCGTGCAATATATCTGTGACCAGGGTTTTGTGCTGATGGGCAGCTCCATCCTCACCTGCCATGATCGCC
AGGCTGGCAGCCCCAAGTGGAGTGACCGGGCCCCTAAATGTCTCCTGGAACAGCTCAAGCCATGCCATGGTCTCAGTGCCCCTGAGAATG
GTGCCCGAAGTCCTGAGAAGCAGCTACACCCAGCAGGGGCCACCATCCACTTCTCGTGTGCCCCTGGCTATGTGCTGAAGGGCCAGGCCA
GCATCAAGTGTGTGCCTGGGCACCCCTCGCATTGGAGTGACCCCCCACCCATCTGTAGGGCTGCCTCTCTGGATGGGTTCTACAACAGTC
GCAGCCTGGATGTTGCCAAGGCACCTGCTGCCTCCAGCACCCTGGATGCTGCCCACATTGCAGCTGCCATCTTCTTGCCACTGGTGGCGA
TGGTGTTGTTGGTAGGAGGTGTATACTTCTACTTCTCCAGGCTCCAGGGAAAAAGCTCCCTGCAGCTGCCCCGCCCCCGCCCCCGCCCCT
ACAACCGCATTACCATAGAGTCAGCGTTTGACAATCCAACTTACGAGACTGGAGAGACGAGAGAATATGAAGTCTCCATCTAGGTGGGGG
CAGTCTAGGGAAGTCAACTCAGACTTGCACCACAGTCCAGCAGCAAGGCTCCTTGCTTCCTGCTGTCCCTCCACCTCCTGTATATACCAC
CTAGGAGGAGATGCCACCAAGCCCTCAAGAAGTTGTGCCCTTCCCCGCCTGCGATGCCCACCATGGCCTATTTTCTTGGTGTCATTGCCC
ACTTGGGGCCCTTCATTGGGCCCATGTCAGGGGGCATCTACCTGTGGGAAGAACATAGCTGGAGCACAAGCATCAACAGCCAGCATCCTG
AGCCTCCTCATGCCCTGGACCAGCCTGGAACACACTAGCAGAGCAGGAGTACCTTTCTCCACATGACCACCATCCCGCCCTGGCATGGCA
ACCTGCAGCAGGATTAACTTGACCATGGTGGGAACTGCACCAGGGTACTCCTCACAGCGCCATCACCAATGGCCAAAACTCCTCTCAACG
GTGACCTCTGGGTAGTCCTGGCATGCCAACATCAGCCTCTTGGGAGGTCTCTAGTTCTCTAAAGTTCTGGACAGTTCTGCCTCCTGCCCT
GTCCCAGTGGAGGCAGTAATTCTAGGAGATCCTAAGGGGTTCAGGGGGACCCTACCCCCACCTCAGGTTGGGCTTCCCTGGGCACTCATG
CTCCACACCAAAGCAGGACACGCCATTTTCCACTGACCACCCTATACCCTGAGGAAAGGGAGACTTTCCTCCGATGTTTATTTAGCTGTT
GCAAACATCTTCACCCTAATAGTCCCTCCTCCAATTCCAGCCACTTGTCAGGCTCTCCTCTTGACCACTGTGTTATGGGATAAGGGGAGG
GGGTGGGCATATTCTGGAGAGGAGCAGAGGTCCAAGGACCCAGGAATTTGGCATGGAACAGGTGGTAGGAGAGCCCCAGGGAGACGCCCA
GGAGCTGGCTGAAAGCCACTTTGTACATGTAATGTATTATATGGGGTCTGGGCTCCAGCCAGAGAACAATCTTTTATTTCTGTTGTTTCC

>6278_6278_19_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000513042_SEZ6_chr17_27296970_ENST00000360295_length(amino acids)=775AA_BP=68
MASARPPPGVGIAGESLPDSGRRLAGGAFRGALRQGAGAEPRLGSGGCGAIAPDAKAMELSCSEAPLYVQNISLREGETVTVEGLGGPDP
LPLANQSFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLSCHFPRRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCL
NATQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSY
EVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEPFVKYGNFSSSTPTYPVGTTVEFSCDPGYTLEQGSIIIECVDPH
DPQWNETEPACRAVCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPGDVLTFYDGDDLTARVLGQYSGPRSH
FKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTW
SEDLPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHDRQAGSPKWSDRAPKCLLEQLKPCHGLSAPENGA
RSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGHPSHWSDPPPICRAASLDGFYNSRSLDVAKAPAASSTLDAAHIAAAIFLPLVAMV

--------------------------------------------------------------
>6278_6278_20_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000513042_SEZ6_chr17_27296970_ENST00000442608_length(transcript)=3112nt_BP=209nt
AAACCTTGGCTTCAGCCCGGCCGCCGCCAGGCGTTGGCATCGCCGGGGAGAGCCTTCCGGACTCCGGGCGGCGGCTGGCTGGGGGCGCGT
TCCGAGGCGCCCTCAGGCAGGGCGCGGGGGCAGAGCCTCGCCTGGGTTCTGGAGGCTGCGGGGCCATCGCTCCAGATGCGAAAGCCATGG
AGTTGAGCTGCAGCGAAGCACCTCTTTACGTCCAGAATATCAGCCTCCGGGAAGGGGAGACAGTGACTGTGGAAGGCCTGGGGGGGCCTG
ACCCACTGCCCCTGGCCAACCAGTCTTTCCTGCTGCGGGGCCAAGTCATCCGCAGCCCCACCCACCAAGCGGCCCTGAGGTTCCAGAGCC
TCCCGCCACCGGCTGGCCCTGGCACCTTCCATTTCCATTACCAAGCCTATCTCCTGAGCTGCCACTTTCCCCGTCGTCCAGCTTATGGAG
ATGTGACTGTCACCAGCCTCCACCCAGGGGGTAGTGCCCGCTTCCATTGTGCCACTGGCTACCAGCTGAAGGGCGCCAGGCATCTCACCT
GTCTCAATGCCACCCAGCCCTTCTGGGATTCAAAGGAGCCCGTCTGCATCGCTGCTTGCGGCGGAGTGATCCGCAATGCCACCACCGGCC
GCATCGTCTCTCCAGGCTTCCCGGGCAACTACAGCAACAACCTCACCTGTCACTGGCTGCTTGAGGCTCCTGAGGGCCAGCGGCTACACC
TGCACTTTGAGAAGGTTTCCCTGGCAGAGGATGATGACAGGCTCATCATTCGCAATGGGGACAACGTGGAGGCCCCACCAGTGTATGATT
CCTATGAGGTGGAATACCTGCCCATTGAGGGCCTGCTCAGCTCTGGCAAACACTTCTTTGTTGAGCTCAGTACTGACAGCAGCGGGGCAG
CTGCAGGCATGGCCCTGCGCTATGAGGCCTTCCAGCAGGGCCATTGCTATGAGCCCTTTGTCAAATACGGTAACTTCAGCAGCAGCACAC
CCACCTACCCTGTGGGTACCACTGTGGAGTTCAGCTGCGACCCTGGCTACACCCTGGAGCAGGGCTCCATCATCATCGAGTGTGTTGACC
CCCACGACCCCCAGTGGAATGAGACAGAGCCAGCCTGCCGAGCCGTGTGCAGCGGGGAGATCACAGACTCGGCTGGCGTGGTACTCTCTC
CCAACTGGCCAGAGCCCTACGGTCGTGGGCAGGATTGTATCTGGGGTGTGCATGTGGAAGAGGACAAGCGCATCATGCTGGACATCCGAG
TGCTGCGCATAGGCCCTGGTGATGTGCTTACCTTCTATGATGGGGATGACCTGACGGCCCGGGTTCTGGGCCAGTACTCAGGGCCCCGTA
GCCACTTCAAGCTCTTTACCTCCATGGCTGATGTCACCATTCAGTTCCAGTCGGACCCCGGGACCTCAGTGCTGGGCTACCAGCAGGGCT
TCGTCATCCACTTCTTTGAGGTGCCCCGCAATGACACATGTCCGGAGCTGCCTGAGATCCCCAATGGCTGGAAGAGCCCATCGCAGCCTG
AGCTAGTGCACGGCACCGTGGTCACTTACCAGTGCTACCCTGGCTACCAGGTAGTGGGATCCAGTGTCCTCATGTGCCAGTGGGACCTAA
CTTGGAGTGAGGACCTGCCCTCATGCCAGAGGGTGACTTCCTGCCACGATCCTGGAGATGTGGAGCACAGCCGACGCCTCATATCCAGCC
CCAAGTTTCCCGTGGGGGCCACCGTGCAATATATCTGTGACCAGGGTTTTGTGCTGATGGGCAGCTCCATCCTCACCTGCCATGATCGCC
AGGCTGGCAGCCCCAAGTGGAGTGACCGGGCCCCTAAATGTCTCCTGGAACAGCTCAAGCCATGCCATGGTCTCAGTGCCCCTGAGAATG
GTGCCCGAAGTCCTGAGAAGCAGCTACACCCAGCAGGGGCCACCATCCACTTCTCGTGTGCCCCTGGCTATGTGCTGAAGGGCCAGGCCA
GCATCAAGTGTGTGCCTGGGCACCCCTCGCATTGGAGTGACCCCCCACCCATCTGTAGGGCTGTTGCCAAGGCACCTGCTGCCTCCAGCA
CCCTGGATGCTGCCCACATTGCAGCTGCCATCTTCTTGCCACTGGTGGCGATGGTGTTGTTGGTAGGAGGTGTATACTTCTACTTCTCCA
GGCTCCAGGGAAAAAGCTCCCTGCAGCTGCCCCGCCCCCGCCCCCGCCCCTACAACCGCATTACCATAGAGTCAGCGTTTGACAATCCAA
CTTACGAGACTGGAGAGACGAGAGAATATGAAGTCTCCATCTAGGTGGGGGCAGTCTAGGGAAGTCAACTCAGACTTGCACCACAGTCCA
GCAGCAAGGCTCCTTGCTTCCTGCTGTCCCTCCACCTCCTGTATATACCACCTAGGAGGAGATGCCACCAAGCCCTCAAGAAGTTGTGCC
CTTCCCCGCCTGCGATGCCCACCATGGCCTATTTTCTTGGTGTCATTGCCCACTTGGGGCCCTTCATTGGGCCCATGTCAGGGGGCATCT
ACCTGTGGGAAGAACATAGCTGGAGCACAAGCATCAACAGCCAGCATCCTGAGCCTCCTCATGCCCTGGACCAGCCTGGAACACACTAGC
AGAGCAGGAGTACCTTTCTCCACATGACCACCATCCCGCCCTGGCATGGCAACCTGCAGCAGGATTAACTTGACCATGGTGGGAACTGCA
CCAGGGTACTCCTCACAGCGCCATCACCAATGGCCAAAACTCCTCTCAACGGTGACCTCTGGGTAGTCCTGGCATGCCAACATCAGCCTC
TTGGGAGGTCTCTAGTTCTCTAAAGTTCTGGACAGTTCTGCCTCCTGCCCTGTCCCAGTGGAGGCAGTAATTCTAGGAGATCCTAAGGGG
TTCAGGGGGACCCTACCCCCACCTCAGGTTGGGCTTCCCTGGGCACTCATGCTCCACACCAAAGCAGGACACGCCATTTTCCACTGACCA
CCCTATACCCTGAGGAAAGGGAGACTTTCCTCCGATGTTTATTTAGCTGTTGCAAACATCTTCACCCTAATAGTCCCTCCTCCAATTCCA

>6278_6278_20_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000513042_SEZ6_chr17_27296970_ENST00000442608_length(amino acids)=762AA_BP=68
MASARPPPGVGIAGESLPDSGRRLAGGAFRGALRQGAGAEPRLGSGGCGAIAPDAKAMELSCSEAPLYVQNISLREGETVTVEGLGGPDP
LPLANQSFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLSCHFPRRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCL
NATQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSY
EVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEPFVKYGNFSSSTPTYPVGTTVEFSCDPGYTLEQGSIIIECVDPH
DPQWNETEPACRAVCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPGDVLTFYDGDDLTARVLGQYSGPRSH
FKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTW
SEDLPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHDRQAGSPKWSDRAPKCLLEQLKPCHGLSAPENGA
RSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGHPSHWSDPPPICRAVAKAPAASSTLDAAHIAAAIFLPLVAMVLLVGGVYFYFSRL

--------------------------------------------------------------
>6278_6278_21_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000545377_SEZ6_chr17_27296970_ENST00000317338_length(transcript)=3393nt_BP=209nt
AAACCTTGGCTTCAGCCCGGCCGCCGCCAGGCGTTGGCATCGCCGGGGAGAGCCTTCCGGACTCCGGGCGGCGGCTGGCTGGGGGCGCGT
TCCGAGGCGCCCTCAGGCAGGGCGCGGGGGCAGAGCCTCGCCTGGGTTCTGGAGGCTGCGGGGCCATCGCTCCAGATGCGAAAGCCATGG
AGTTGAGCTGCAGCGAAGCACCTCTTTACGTCCAGAATATCAGCCTCCGGGAAGGGGAGACAGTGACTGTGGAAGGCCTGGGGGGGCCTG
ACCCACTGCCCCTGGCCAACCAGTCTTTCCTGCTGCGGGGCCAAGTCATCCGCAGCCCCACCCACCAAGCGGCCCTGAGGTTCCAGAGCC
TCCCGCCACCGGCTGGCCCTGGCACCTTCCATTTCCATTACCAAGCCTATCTCCTGAGCTGCCACTTTCCCCGTCGTCCAGCTTATGGAG
ATGTGACTGTCACCAGCCTCCACCCAGGGGGTAGTGCCCGCTTCCATTGTGCCACTGGCTACCAGCTGAAGGGCGCCAGGCATCTCACCT
GTCTCAATGCCACCCAGCCCTTCTGGGATTCAAAGGAGCCCGTCTGCATCGCTGCTTGCGGCGGAGTGATCCGCAATGCCACCACCGGCC
GCATCGTCTCTCCAGGCTTCCCGGGCAACTACAGCAACAACCTCACCTGTCACTGGCTGCTTGAGGCTCCTGAGGGCCAGCGGCTACACC
TGCACTTTGAGAAGGTTTCCCTGGCAGAGGATGATGACAGGCTCATCATTCGCAATGGGGACAACGTGGAGGCCCCACCAGTGTATGATT
CCTATGAGGTGGAATACCTGCCCATTGAGGGCCTGCTCAGCTCTGGCAAACACTTCTTTGTTGAGCTCAGTACTGACAGCAGCGGGGCAG
CTGCAGGCATGGCCCTGCGCTATGAGGCCTTCCAGCAGGGCCATTGCTATGAGCCCTTTGTCAAATACGGTAACTTCAGCAGCAGCACAC
CCACCTACCCTGTGGGTACCACTGTGGAGTTCAGCTGCGACCCTGGCTACACCCTGGAGCAGGGCTCCATCATCATCGAGTGTGTTGACC
CCCACGACCCCCAGTGGAATGAGACAGAGCCAGCCTGCCGAGCCGTGTGCAGCGGGGAGATCACAGACTCGGCTGGCGTGGTACTCTCTC
CCAACTGGCCAGAGCCCTACGGTCGTGGGCAGGATTGTATCTGGGGTGTGCATGTGGAAGAGGACAAGCGCATCATGCTGGACATCCGAG
TGCTGCGCATAGGCCCTGGTGATGTGCTTACCTTCTATGATGGGGATGACCTGACGGCCCGGGTTCTGGGCCAGTACTCAGGGCCCCGTA
GCCACTTCAAGCTCTTTACCTCCATGGCTGATGTCACCATTCAGTTCCAGTCGGACCCCGGGACCTCAGTGCTGGGCTACCAGCAGGGCT
TCGTCATCCACTTCTTTGAGGTGCCCCGCAATGACACATGTCCGGAGCTGCCTGAGATCCCCAATGGCTGGAAGAGCCCATCGCAGCCTG
AGCTAGTGCACGGCACCGTGGTCACTTACCAGTGCTACCCTGGCTACCAGGTAGTGGGATCCAGTGTCCTCATGTGCCAGTGGGACCTAA
CTTGGAGTGAGGACCTGCCCTCATGCCAGAGGGTGACTTCCTGCCACGATCCTGGAGATGTGGAGCACAGCCGACGCCTCATATCCAGCC
CCAAGTTTCCCGTGGGGGCCACCGTGCAATATATCTGTGACCAGGGTTTTGTGCTGATGGGCAGCTCCATCCTCACCTGCCATGATCGCC
AGGCTGGCAGCCCCAAGTGGAGTGACCGGGCCCCTAAATGTCTCCTGGAACAGCTCAAGCCATGCCATGGTCTCAGTGCCCCTGAGAATG
GTGCCCGAAGTCCTGAGAAGCAGCTACACCCAGCAGGGGCCACCATCCACTTCTCGTGTGCCCCTGGCTATGTGCTGAAGGGCCAGGCCA
GCATCAAGTGTGTGCCTGGGCACCCCTCGCATTGGAGTGACCCCCCACCCATCTGTAGGGCTGCCTCTCTGGATGGGTTCTACAACAGTC
GCAGCCTGGATGTTGCCAAGGCACCTGCTGCCTCCAGCACCCTGGATGCTGCCCACATTGCAGCTGCCATCTTCTTGCCACTGGTGGCGA
TGGTGTTGTTGGTAGGAGGTGTATACTTCTACTTCTCCAGGCTCCAGGGAAAAAGCTCCCTGCAGCTGCCCCGCCCCCGCCCCCGCCCCT
ACAACCGCATTACCATAGAGTCAGCGTTTGACAATCCAACTTACGAGACTGGATCTCTTTCCTTTGCAGGAGACGAGAGAATATGAAGTC
TCCATCTAGGTGGGGGCAGTCTAGGGAAGTCAACTCAGACTTGCACCACAGTCCAGCAGCAAGGCTCCTTGCTTCCTGCTGTCCCTCCAC
CTCCTGTATATACCACCTAGGAGGAGATGCCACCAAGCCCTCAAGAAGTTGTGCCCTTCCCCGCCTGCGATGCCCACCATGGCCTATTTT
CTTGGTGTCATTGCCCACTTGGGGCCCTTCATTGGGCCCATGTCAGGGGGCATCTACCTGTGGGAAGAACATAGCTGGAGCACAAGCATC
AACAGCCAGCATCCTGAGCCTCCTCATGCCCTGGACCAGCCTGGAACACACTAGCAGAGCAGGAGTACCTTTCTCCACATGACCACCATC
CCGCCCTGGCATGGCAACCTGCAGCAGGATTAACTTGACCATGGTGGGAACTGCACCAGGGTACTCCTCACAGCGCCATCACCAATGGCC
AAAACTCCTCTCAACGGTGACCTCTGGGTAGTCCTGGCATGCCAACATCAGCCTCTTGGGAGGTCTCTAGTTCTCTAAAGTTCTGGACAG
TTCTGCCTCCTGCCCTGTCCCAGTGGAGGCAGTAATTCTAGGAGATCCTAAGGGGTTCAGGGGGACCCTACCCCCACCTCAGGTTGGGCT
TCCCTGGGCACTCATGCTCCACACCAAAGCAGGACACGCCATTTTCCACTGACCACCCTATACCCTGAGGAAAGGGAGACTTTCCTCCGA
TGTTTATTTAGCTGTTGCAAACATCTTCACCCTAATAGTCCCTCCTCCAATTCCAGCCACTTGTCAGGCTCTCCTCTTGACCACTGTGTT
ATGGGATAAGGGGAGGGGGTGGGCATATTCTGGAGAGGAGCAGAGGTCCAAGGACCCAGGAATTTGGCATGGAACAGGTGGTAGGAGAGC
CCCAGGGAGACGCCCAGGAGCTGGCTGAAAGCCACTTTGTACATGTAATGTATTATATGGGGTCTGGGCTCCAGCCAGAGAACAATCTTT

>6278_6278_21_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000545377_SEZ6_chr17_27296970_ENST00000317338_length(amino acids)=776AA_BP=68
MASARPPPGVGIAGESLPDSGRRLAGGAFRGALRQGAGAEPRLGSGGCGAIAPDAKAMELSCSEAPLYVQNISLREGETVTVEGLGGPDP
LPLANQSFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLSCHFPRRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCL
NATQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSY
EVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEPFVKYGNFSSSTPTYPVGTTVEFSCDPGYTLEQGSIIIECVDPH
DPQWNETEPACRAVCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPGDVLTFYDGDDLTARVLGQYSGPRSH
FKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTW
SEDLPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHDRQAGSPKWSDRAPKCLLEQLKPCHGLSAPENGA
RSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGHPSHWSDPPPICRAASLDGFYNSRSLDVAKAPAASSTLDAAHIAAAIFLPLVAMV

--------------------------------------------------------------
>6278_6278_22_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000545377_SEZ6_chr17_27296970_ENST00000335960_length(transcript)=878nt_BP=209nt
AAACCTTGGCTTCAGCCCGGCCGCCGCCAGGCGTTGGCATCGCCGGGGAGAGCCTTCCGGACTCCGGGCGGCGGCTGGCTGGGGGCGCGT
TCCGAGGCGCCCTCAGGCAGGGCGCGGGGGCAGAGCCTCGCCTGGGTTCTGGAGGCTGCGGGGCCATCGCTCCAGATGCGAAAGCCATGG
AGTTGAGCTGCAGCGAAGCACCTCTTTACGTCCAGAATATCAGCCTCCGGGAAGGGGAGACAGTGACTGTGGAAGGCCTGGGGGGGCCTG
ACCCACTGCCCCTGGCCAACCAGTCTTTCCTGCTGCGGGGCCAAGTCATCCGCAGCCCCACCCACCAAGCGGCCCTGAGGTTCCAGAGCC
TCCCGCCACCGGCTGGCCCTGGCACCTTCCATTTCCATTACCAAGCCTATCTCCTGAGCTGCCACTTTCCCCGTCGTCCAGCTTATGGAG
ATGTGACTGTCACCAGCCTCCACCCAGGGGGTAGTGCCCGCTTCCATTGTGCCACTGGCTACCAGCTGAAGGGCGCCAGGCATCTCACCT
GTCTCAATGCCACCCAGCCCTTCTGGGATTCAAAGGAGCCCGTCTGCATCGCTGCTTGCGGCGGAGTGATCCGCAATGCCACCACCGGCC
GCATCGTCTCTCCAGGCTTCCCGGGCAACTACAGCAACAACCTCACCTGTCACTGGCTGCTTGAGGCTCCTGAGGGCCAGCGGCTACACC
TGCACTTTGAGAAGGTTTCCCTGGCAGAGGATGATGACAGGCTCATCATTCGCAATGGGGACAACGTGGAGGCCCCACCAGTGTATGATT

>6278_6278_22_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000545377_SEZ6_chr17_27296970_ENST00000335960_length(amino acids)=291AA_BP=68
MASARPPPGVGIAGESLPDSGRRLAGGAFRGALRQGAGAEPRLGSGGCGAIAPDAKAMELSCSEAPLYVQNISLREGETVTVEGLGGPDP
LPLANQSFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLSCHFPRRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCL
NATQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSY

--------------------------------------------------------------
>6278_6278_23_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000545377_SEZ6_chr17_27296970_ENST00000360295_length(transcript)=3381nt_BP=209nt
AAACCTTGGCTTCAGCCCGGCCGCCGCCAGGCGTTGGCATCGCCGGGGAGAGCCTTCCGGACTCCGGGCGGCGGCTGGCTGGGGGCGCGT
TCCGAGGCGCCCTCAGGCAGGGCGCGGGGGCAGAGCCTCGCCTGGGTTCTGGAGGCTGCGGGGCCATCGCTCCAGATGCGAAAGCCATGG
AGTTGAGCTGCAGCGAAGCACCTCTTTACGTCCAGAATATCAGCCTCCGGGAAGGGGAGACAGTGACTGTGGAAGGCCTGGGGGGGCCTG
ACCCACTGCCCCTGGCCAACCAGTCTTTCCTGCTGCGGGGCCAAGTCATCCGCAGCCCCACCCACCAAGCGGCCCTGAGGTTCCAGAGCC
TCCCGCCACCGGCTGGCCCTGGCACCTTCCATTTCCATTACCAAGCCTATCTCCTGAGCTGCCACTTTCCCCGTCGTCCAGCTTATGGAG
ATGTGACTGTCACCAGCCTCCACCCAGGGGGTAGTGCCCGCTTCCATTGTGCCACTGGCTACCAGCTGAAGGGCGCCAGGCATCTCACCT
GTCTCAATGCCACCCAGCCCTTCTGGGATTCAAAGGAGCCCGTCTGCATCGCTGCTTGCGGCGGAGTGATCCGCAATGCCACCACCGGCC
GCATCGTCTCTCCAGGCTTCCCGGGCAACTACAGCAACAACCTCACCTGTCACTGGCTGCTTGAGGCTCCTGAGGGCCAGCGGCTACACC
TGCACTTTGAGAAGGTTTCCCTGGCAGAGGATGATGACAGGCTCATCATTCGCAATGGGGACAACGTGGAGGCCCCACCAGTGTATGATT
CCTATGAGGTGGAATACCTGCCCATTGAGGGCCTGCTCAGCTCTGGCAAACACTTCTTTGTTGAGCTCAGTACTGACAGCAGCGGGGCAG
CTGCAGGCATGGCCCTGCGCTATGAGGCCTTCCAGCAGGGCCATTGCTATGAGCCCTTTGTCAAATACGGTAACTTCAGCAGCAGCACAC
CCACCTACCCTGTGGGTACCACTGTGGAGTTCAGCTGCGACCCTGGCTACACCCTGGAGCAGGGCTCCATCATCATCGAGTGTGTTGACC
CCCACGACCCCCAGTGGAATGAGACAGAGCCAGCCTGCCGAGCCGTGTGCAGCGGGGAGATCACAGACTCGGCTGGCGTGGTACTCTCTC
CCAACTGGCCAGAGCCCTACGGTCGTGGGCAGGATTGTATCTGGGGTGTGCATGTGGAAGAGGACAAGCGCATCATGCTGGACATCCGAG
TGCTGCGCATAGGCCCTGGTGATGTGCTTACCTTCTATGATGGGGATGACCTGACGGCCCGGGTTCTGGGCCAGTACTCAGGGCCCCGTA
GCCACTTCAAGCTCTTTACCTCCATGGCTGATGTCACCATTCAGTTCCAGTCGGACCCCGGGACCTCAGTGCTGGGCTACCAGCAGGGCT
TCGTCATCCACTTCTTTGAGGTGCCCCGCAATGACACATGTCCGGAGCTGCCTGAGATCCCCAATGGCTGGAAGAGCCCATCGCAGCCTG
AGCTAGTGCACGGCACCGTGGTCACTTACCAGTGCTACCCTGGCTACCAGGTAGTGGGATCCAGTGTCCTCATGTGCCAGTGGGACCTAA
CTTGGAGTGAGGACCTGCCCTCATGCCAGAGGGTGACTTCCTGCCACGATCCTGGAGATGTGGAGCACAGCCGACGCCTCATATCCAGCC
CCAAGTTTCCCGTGGGGGCCACCGTGCAATATATCTGTGACCAGGGTTTTGTGCTGATGGGCAGCTCCATCCTCACCTGCCATGATCGCC
AGGCTGGCAGCCCCAAGTGGAGTGACCGGGCCCCTAAATGTCTCCTGGAACAGCTCAAGCCATGCCATGGTCTCAGTGCCCCTGAGAATG
GTGCCCGAAGTCCTGAGAAGCAGCTACACCCAGCAGGGGCCACCATCCACTTCTCGTGTGCCCCTGGCTATGTGCTGAAGGGCCAGGCCA
GCATCAAGTGTGTGCCTGGGCACCCCTCGCATTGGAGTGACCCCCCACCCATCTGTAGGGCTGCCTCTCTGGATGGGTTCTACAACAGTC
GCAGCCTGGATGTTGCCAAGGCACCTGCTGCCTCCAGCACCCTGGATGCTGCCCACATTGCAGCTGCCATCTTCTTGCCACTGGTGGCGA
TGGTGTTGTTGGTAGGAGGTGTATACTTCTACTTCTCCAGGCTCCAGGGAAAAAGCTCCCTGCAGCTGCCCCGCCCCCGCCCCCGCCCCT
ACAACCGCATTACCATAGAGTCAGCGTTTGACAATCCAACTTACGAGACTGGAGAGACGAGAGAATATGAAGTCTCCATCTAGGTGGGGG
CAGTCTAGGGAAGTCAACTCAGACTTGCACCACAGTCCAGCAGCAAGGCTCCTTGCTTCCTGCTGTCCCTCCACCTCCTGTATATACCAC
CTAGGAGGAGATGCCACCAAGCCCTCAAGAAGTTGTGCCCTTCCCCGCCTGCGATGCCCACCATGGCCTATTTTCTTGGTGTCATTGCCC
ACTTGGGGCCCTTCATTGGGCCCATGTCAGGGGGCATCTACCTGTGGGAAGAACATAGCTGGAGCACAAGCATCAACAGCCAGCATCCTG
AGCCTCCTCATGCCCTGGACCAGCCTGGAACACACTAGCAGAGCAGGAGTACCTTTCTCCACATGACCACCATCCCGCCCTGGCATGGCA
ACCTGCAGCAGGATTAACTTGACCATGGTGGGAACTGCACCAGGGTACTCCTCACAGCGCCATCACCAATGGCCAAAACTCCTCTCAACG
GTGACCTCTGGGTAGTCCTGGCATGCCAACATCAGCCTCTTGGGAGGTCTCTAGTTCTCTAAAGTTCTGGACAGTTCTGCCTCCTGCCCT
GTCCCAGTGGAGGCAGTAATTCTAGGAGATCCTAAGGGGTTCAGGGGGACCCTACCCCCACCTCAGGTTGGGCTTCCCTGGGCACTCATG
CTCCACACCAAAGCAGGACACGCCATTTTCCACTGACCACCCTATACCCTGAGGAAAGGGAGACTTTCCTCCGATGTTTATTTAGCTGTT
GCAAACATCTTCACCCTAATAGTCCCTCCTCCAATTCCAGCCACTTGTCAGGCTCTCCTCTTGACCACTGTGTTATGGGATAAGGGGAGG
GGGTGGGCATATTCTGGAGAGGAGCAGAGGTCCAAGGACCCAGGAATTTGGCATGGAACAGGTGGTAGGAGAGCCCCAGGGAGACGCCCA
GGAGCTGGCTGAAAGCCACTTTGTACATGTAATGTATTATATGGGGTCTGGGCTCCAGCCAGAGAACAATCTTTTATTTCTGTTGTTTCC

>6278_6278_23_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000545377_SEZ6_chr17_27296970_ENST00000360295_length(amino acids)=775AA_BP=68
MASARPPPGVGIAGESLPDSGRRLAGGAFRGALRQGAGAEPRLGSGGCGAIAPDAKAMELSCSEAPLYVQNISLREGETVTVEGLGGPDP
LPLANQSFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLSCHFPRRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCL
NATQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSY
EVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEPFVKYGNFSSSTPTYPVGTTVEFSCDPGYTLEQGSIIIECVDPH
DPQWNETEPACRAVCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPGDVLTFYDGDDLTARVLGQYSGPRSH
FKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTW
SEDLPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHDRQAGSPKWSDRAPKCLLEQLKPCHGLSAPENGA
RSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGHPSHWSDPPPICRAASLDGFYNSRSLDVAKAPAASSTLDAAHIAAAIFLPLVAMV

--------------------------------------------------------------
>6278_6278_24_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000545377_SEZ6_chr17_27296970_ENST00000442608_length(transcript)=3112nt_BP=209nt
AAACCTTGGCTTCAGCCCGGCCGCCGCCAGGCGTTGGCATCGCCGGGGAGAGCCTTCCGGACTCCGGGCGGCGGCTGGCTGGGGGCGCGT
TCCGAGGCGCCCTCAGGCAGGGCGCGGGGGCAGAGCCTCGCCTGGGTTCTGGAGGCTGCGGGGCCATCGCTCCAGATGCGAAAGCCATGG
AGTTGAGCTGCAGCGAAGCACCTCTTTACGTCCAGAATATCAGCCTCCGGGAAGGGGAGACAGTGACTGTGGAAGGCCTGGGGGGGCCTG
ACCCACTGCCCCTGGCCAACCAGTCTTTCCTGCTGCGGGGCCAAGTCATCCGCAGCCCCACCCACCAAGCGGCCCTGAGGTTCCAGAGCC
TCCCGCCACCGGCTGGCCCTGGCACCTTCCATTTCCATTACCAAGCCTATCTCCTGAGCTGCCACTTTCCCCGTCGTCCAGCTTATGGAG
ATGTGACTGTCACCAGCCTCCACCCAGGGGGTAGTGCCCGCTTCCATTGTGCCACTGGCTACCAGCTGAAGGGCGCCAGGCATCTCACCT
GTCTCAATGCCACCCAGCCCTTCTGGGATTCAAAGGAGCCCGTCTGCATCGCTGCTTGCGGCGGAGTGATCCGCAATGCCACCACCGGCC
GCATCGTCTCTCCAGGCTTCCCGGGCAACTACAGCAACAACCTCACCTGTCACTGGCTGCTTGAGGCTCCTGAGGGCCAGCGGCTACACC
TGCACTTTGAGAAGGTTTCCCTGGCAGAGGATGATGACAGGCTCATCATTCGCAATGGGGACAACGTGGAGGCCCCACCAGTGTATGATT
CCTATGAGGTGGAATACCTGCCCATTGAGGGCCTGCTCAGCTCTGGCAAACACTTCTTTGTTGAGCTCAGTACTGACAGCAGCGGGGCAG
CTGCAGGCATGGCCCTGCGCTATGAGGCCTTCCAGCAGGGCCATTGCTATGAGCCCTTTGTCAAATACGGTAACTTCAGCAGCAGCACAC
CCACCTACCCTGTGGGTACCACTGTGGAGTTCAGCTGCGACCCTGGCTACACCCTGGAGCAGGGCTCCATCATCATCGAGTGTGTTGACC
CCCACGACCCCCAGTGGAATGAGACAGAGCCAGCCTGCCGAGCCGTGTGCAGCGGGGAGATCACAGACTCGGCTGGCGTGGTACTCTCTC
CCAACTGGCCAGAGCCCTACGGTCGTGGGCAGGATTGTATCTGGGGTGTGCATGTGGAAGAGGACAAGCGCATCATGCTGGACATCCGAG
TGCTGCGCATAGGCCCTGGTGATGTGCTTACCTTCTATGATGGGGATGACCTGACGGCCCGGGTTCTGGGCCAGTACTCAGGGCCCCGTA
GCCACTTCAAGCTCTTTACCTCCATGGCTGATGTCACCATTCAGTTCCAGTCGGACCCCGGGACCTCAGTGCTGGGCTACCAGCAGGGCT
TCGTCATCCACTTCTTTGAGGTGCCCCGCAATGACACATGTCCGGAGCTGCCTGAGATCCCCAATGGCTGGAAGAGCCCATCGCAGCCTG
AGCTAGTGCACGGCACCGTGGTCACTTACCAGTGCTACCCTGGCTACCAGGTAGTGGGATCCAGTGTCCTCATGTGCCAGTGGGACCTAA
CTTGGAGTGAGGACCTGCCCTCATGCCAGAGGGTGACTTCCTGCCACGATCCTGGAGATGTGGAGCACAGCCGACGCCTCATATCCAGCC
CCAAGTTTCCCGTGGGGGCCACCGTGCAATATATCTGTGACCAGGGTTTTGTGCTGATGGGCAGCTCCATCCTCACCTGCCATGATCGCC
AGGCTGGCAGCCCCAAGTGGAGTGACCGGGCCCCTAAATGTCTCCTGGAACAGCTCAAGCCATGCCATGGTCTCAGTGCCCCTGAGAATG
GTGCCCGAAGTCCTGAGAAGCAGCTACACCCAGCAGGGGCCACCATCCACTTCTCGTGTGCCCCTGGCTATGTGCTGAAGGGCCAGGCCA
GCATCAAGTGTGTGCCTGGGCACCCCTCGCATTGGAGTGACCCCCCACCCATCTGTAGGGCTGTTGCCAAGGCACCTGCTGCCTCCAGCA
CCCTGGATGCTGCCCACATTGCAGCTGCCATCTTCTTGCCACTGGTGGCGATGGTGTTGTTGGTAGGAGGTGTATACTTCTACTTCTCCA
GGCTCCAGGGAAAAAGCTCCCTGCAGCTGCCCCGCCCCCGCCCCCGCCCCTACAACCGCATTACCATAGAGTCAGCGTTTGACAATCCAA
CTTACGAGACTGGAGAGACGAGAGAATATGAAGTCTCCATCTAGGTGGGGGCAGTCTAGGGAAGTCAACTCAGACTTGCACCACAGTCCA
GCAGCAAGGCTCCTTGCTTCCTGCTGTCCCTCCACCTCCTGTATATACCACCTAGGAGGAGATGCCACCAAGCCCTCAAGAAGTTGTGCC
CTTCCCCGCCTGCGATGCCCACCATGGCCTATTTTCTTGGTGTCATTGCCCACTTGGGGCCCTTCATTGGGCCCATGTCAGGGGGCATCT
ACCTGTGGGAAGAACATAGCTGGAGCACAAGCATCAACAGCCAGCATCCTGAGCCTCCTCATGCCCTGGACCAGCCTGGAACACACTAGC
AGAGCAGGAGTACCTTTCTCCACATGACCACCATCCCGCCCTGGCATGGCAACCTGCAGCAGGATTAACTTGACCATGGTGGGAACTGCA
CCAGGGTACTCCTCACAGCGCCATCACCAATGGCCAAAACTCCTCTCAACGGTGACCTCTGGGTAGTCCTGGCATGCCAACATCAGCCTC
TTGGGAGGTCTCTAGTTCTCTAAAGTTCTGGACAGTTCTGCCTCCTGCCCTGTCCCAGTGGAGGCAGTAATTCTAGGAGATCCTAAGGGG
TTCAGGGGGACCCTACCCCCACCTCAGGTTGGGCTTCCCTGGGCACTCATGCTCCACACCAAAGCAGGACACGCCATTTTCCACTGACCA
CCCTATACCCTGAGGAAAGGGAGACTTTCCTCCGATGTTTATTTAGCTGTTGCAAACATCTTCACCCTAATAGTCCCTCCTCCAATTCCA

>6278_6278_24_ARHGEF28-SEZ6_ARHGEF28_chr5_72980709_ENST00000545377_SEZ6_chr17_27296970_ENST00000442608_length(amino acids)=762AA_BP=68
MASARPPPGVGIAGESLPDSGRRLAGGAFRGALRQGAGAEPRLGSGGCGAIAPDAKAMELSCSEAPLYVQNISLREGETVTVEGLGGPDP
LPLANQSFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLSCHFPRRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCL
NATQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSY
EVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEPFVKYGNFSSSTPTYPVGTTVEFSCDPGYTLEQGSIIIECVDPH
DPQWNETEPACRAVCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPGDVLTFYDGDDLTARVLGQYSGPRSH
FKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTW
SEDLPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHDRQAGSPKWSDRAPKCLLEQLKPCHGLSAPENGA
RSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGHPSHWSDPPPICRAVAKAPAASSTLDAAHIAAAIFLPLVAMVLLVGGVYFYFSRL

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Fusion Gene PPI Analysis for RGNEF-SEZ6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000287898+2361425_170511.01688.0microtubules
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000296794+2351425_170511.01652.0microtubules
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000296799+1281425_170501393.0microtubules
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000426542+1351425_170511.01706.0microtubules
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000437974+1361425_170511.01732.0microtubules
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000513042+2361425_170511.01706.0microtubules
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000545377+2371425_170511.01732.0microtubules
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000287898+2361295_130411.01688.0PTK2/FAK1%3B required for regulation of axonal branching and synapse formation
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000296794+2351295_130411.01652.0PTK2/FAK1%3B required for regulation of axonal branching and synapse formation
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000296799+1281295_130401393.0PTK2/FAK1%3B required for regulation of axonal branching and synapse formation
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000426542+1351295_130411.01706.0PTK2/FAK1%3B required for regulation of axonal branching and synapse formation
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000437974+1361295_130411.01732.0PTK2/FAK1%3B required for regulation of axonal branching and synapse formation
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000513042+2361295_130411.01706.0PTK2/FAK1%3B required for regulation of axonal branching and synapse formation
HgeneARHGEF28chr5:72980709chr17:27296970ENST00000545377+2371295_130411.01732.0PTK2/FAK1%3B required for regulation of axonal branching and synapse formation


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RGNEF-SEZ6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RGNEF-SEZ6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARHGEF28C0002736Amyotrophic Lateral Sclerosis1GENOMICS_ENGLAND
TgeneC0023893Liver Cirrhosis, Experimental1CTD_human