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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
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Fusion gene:SMYD3-TFB2M (FusionGDB2 ID:HG64754TG64216)

Fusion Gene Summary for SMYD3-TFB2M

Fusion gene summary

Fusion gene information	Fusion gene name: SMYD3-TFB2M
	Fusion gene ID: hg64754tg64216
		Hgene	Tgene
	Gene symbol	SMYD3	TFB2M
	Gene ID	64754	64216
	Gene name	SET and MYND domain containing 3	transcription factor B2, mitochondrial
	Synonyms	KMT3E\|ZMYND1\|ZNFN3A1\|bA74P14.1	Hkp1\|mtTFB2
	Cytomap	('SMYD3')('TFB2M') 1q44	1q44
	Type of gene	protein-coding	protein-coding
	Description	histone-lysine N-methyltransferase SMYD3SET and MYND domain-containing protein 3bA74P14.1 (novel protein)zinc finger MYND domain-containing protein 1zinc finger protein, subfamily 3A (MYND domain containing), 1zinc finger, MYND domain containing 1	dimethyladenosine transferase 2, mitochondrialHCV NS5A-transactivated protein 5S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2h-mtTFBh-mtTFB2hTFB2Mhepatitis C virus NS5A-transactivated protein 5mitochondrial 12S rRNA dimethylase
	Modification date	20200320	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000388985, ENST00000403792, ENST00000490107, ENST00000541742, ENST00000366517,	ENST00000388985, ENST00000490107, ENST00000541742, ENST00000366517, ENST00000403792,
Fusion gene scores	* DoF score	22 X 13 X 10=2860	4 X 5 X 5=100
	# samples	24	5
	** MAII score	log2(24/2860*10)=-3.57490883605723 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SMYD3 [Title/Abstract] AND TFB2M [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SMYD3(246518332)-TFB2M(246720836), # samples:1 SMYD3(246670356)-TFB2M(246711909), # samples:1
Anticipated loss of major functional domain due to fusion event.	SMYD3-TFB2M seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SMYD3-TFB2M seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SMYD3-TFB2M seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SMYD3-TFB2M seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TFB2M-SMYD3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TFB2M-SMYD3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SMYD3-TFB2M seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. SMYD3-TFB2M seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. SMYD3-TFB2M seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. TFB2M-SMYD3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. TFB2M-SMYD3 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. TFB2M-SMYD3 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	TFB2M	GO:0006390	mitochondrial transcription	12068295
Tgene	TFB2M	GO:0006391	transcription initiation from mitochondrial promoter	20410300\|29149603
Tgene	TFB2M	GO:0045893	positive regulation of transcription, DNA-templated	20410300

Fusion gene breakpoints across SMYD3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TFB2M (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A2-A25B-01A	SMYD3	chr1	246670356	-	TFB2M	chr1	246711909	-
ChimerDB4	ESCA	TCGA-L5-A4OE	SMYD3	chr1	246518332	-	TFB2M	chr1	246720836	-

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Fusion Gene ORF analysis for SMYD3-TFB2M

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000388985	ENST00000544618	SMYD3	chr1	246670356	-	TFB2M	chr1	246711909	-
5CDS-3UTR	ENST00000403792	ENST00000544618	SMYD3	chr1	246670356	-	TFB2M	chr1	246711909	-
5CDS-intron	ENST00000388985	ENST00000544618	SMYD3	chr1	246518332	-	TFB2M	chr1	246720836	-
5CDS-intron	ENST00000403792	ENST00000544618	SMYD3	chr1	246518332	-	TFB2M	chr1	246720836	-
5CDS-intron	ENST00000490107	ENST00000544618	SMYD3	chr1	246518332	-	TFB2M	chr1	246720836	-
5CDS-intron	ENST00000541742	ENST00000544618	SMYD3	chr1	246518332	-	TFB2M	chr1	246720836	-
5UTR-3CDS	ENST00000490107	ENST00000366514	SMYD3	chr1	246670356	-	TFB2M	chr1	246711909	-
5UTR-3UTR	ENST00000490107	ENST00000544618	SMYD3	chr1	246670356	-	TFB2M	chr1	246711909	-
Frame-shift	ENST00000541742	ENST00000366514	SMYD3	chr1	246518332	-	TFB2M	chr1	246720836	-
In-frame	ENST00000388985	ENST00000366514	SMYD3	chr1	246670356	-	TFB2M	chr1	246711909	-
In-frame	ENST00000388985	ENST00000366514	SMYD3	chr1	246518332	-	TFB2M	chr1	246720836	-
In-frame	ENST00000403792	ENST00000366514	SMYD3	chr1	246670356	-	TFB2M	chr1	246711909	-
In-frame	ENST00000403792	ENST00000366514	SMYD3	chr1	246518332	-	TFB2M	chr1	246720836	-
In-frame	ENST00000490107	ENST00000366514	SMYD3	chr1	246518332	-	TFB2M	chr1	246720836	-
intron-3CDS	ENST00000366517	ENST00000366514	SMYD3	chr1	246670356	-	TFB2M	chr1	246711909	-
intron-3CDS	ENST00000366517	ENST00000366514	SMYD3	chr1	246518332	-	TFB2M	chr1	246720836	-
intron-3CDS	ENST00000541742	ENST00000366514	SMYD3	chr1	246670356	-	TFB2M	chr1	246711909	-
intron-3UTR	ENST00000366517	ENST00000544618	SMYD3	chr1	246670356	-	TFB2M	chr1	246711909	-
intron-3UTR	ENST00000541742	ENST00000544618	SMYD3	chr1	246670356	-	TFB2M	chr1	246711909	-
intron-intron	ENST00000366517	ENST00000544618	SMYD3	chr1	246518332	-	TFB2M	chr1	246720836	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000490107	SMYD3	chr1	246518332	-	ENST00000366514	TFB2M	chr1	246720836	-	1528	268	16	1056	346
ENST00000388985	SMYD3	chr1	246518332	-	ENST00000366514	TFB2M	chr1	246720836	-	1488	228	0	1016	338
ENST00000403792	SMYD3	chr1	246518332	-	ENST00000366514	TFB2M	chr1	246720836	-	1583	323	50	1111	353

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000490107	ENST00000366514	SMYD3	chr1	246518332	-	TFB2M	chr1	246720836	-	0.000375424	0.9996246
ENST00000388985	ENST00000366514	SMYD3	chr1	246518332	-	TFB2M	chr1	246720836	-	0.000353909	0.99964607
ENST00000403792	ENST00000366514	SMYD3	chr1	246518332	-	TFB2M	chr1	246720836	-	0.00038196	0.99961805

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Fusion Genomic Features for SMYD3-TFB2M

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

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Fusion Protein Features for SMYD3-TFB2M

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:246518332/chr1:246720836)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SMYD3

chr1:246518332

chr1:246720836

ENST00000388985

14_16

429.0

Region

S-adenosyl-L-methionine binding

Hgene

SMYD3

chr1:246518332

chr1:246720836

ENST00000490107

14_16

370.0

Region

S-adenosyl-L-methionine binding

Hgene

SMYD3

chr1:246518332

chr1:246720836

ENST00000541742

14_16

370.0

Region

S-adenosyl-L-methionine binding

Hgene

SMYD3

chr1:246670356

chr1:246711909

ENST00000388985

14_16

429.0

Region

S-adenosyl-L-methionine binding

Tgene

TFB2M

chr1:246518332

chr1:246720836

ENST00000366514

330_331

134

397.0

Region

DNA binding

Tgene

TFB2M

chr1:246670356

chr1:246711909

ENST00000366514

330_331

265

397.0

Region

DNA binding

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SMYD3

chr1:246518332

chr1:246720836

ENST00000388985

4_240

429.0

Domain

SET

Hgene

SMYD3

chr1:246518332

chr1:246720836

ENST00000490107

4_240

370.0

Domain

SET

Hgene

SMYD3

chr1:246518332

chr1:246720836

ENST00000541742

4_240

370.0

Domain

SET

Hgene

SMYD3

chr1:246670356

chr1:246711909

ENST00000388985

4_240

429.0

Domain

SET

Hgene

SMYD3

chr1:246670356

chr1:246711909

ENST00000490107

4_240

370.0

Domain

SET

Hgene

SMYD3

chr1:246670356

chr1:246711909

ENST00000541742

4_240

370.0

Domain

SET

Hgene

SMYD3

chr1:246518332

chr1:246720836

ENST00000388985

205_206

429.0

Region

S-adenosyl-L-methionine binding

Hgene

SMYD3

chr1:246518332

chr1:246720836

ENST00000490107

205_206

370.0

Region

S-adenosyl-L-methionine binding

Hgene

SMYD3

chr1:246518332

chr1:246720836

ENST00000541742

205_206

370.0

Region

S-adenosyl-L-methionine binding

Hgene

SMYD3

chr1:246670356

chr1:246711909

ENST00000388985

205_206

429.0

Region

S-adenosyl-L-methionine binding

Hgene

SMYD3

chr1:246670356

chr1:246711909

ENST00000490107

14_16

370.0

Region

S-adenosyl-L-methionine binding

Hgene

SMYD3

chr1:246670356

chr1:246711909

ENST00000490107

205_206

370.0

Region

S-adenosyl-L-methionine binding

Hgene

SMYD3

chr1:246670356

chr1:246711909

ENST00000541742

14_16

370.0

Region

S-adenosyl-L-methionine binding

Hgene

SMYD3

chr1:246670356

chr1:246711909

ENST00000541742

205_206

370.0

Region

S-adenosyl-L-methionine binding

Hgene

SMYD3

chr1:246518332

chr1:246720836

ENST00000388985

49_87

429.0

Zinc finger

MYND-type

Hgene

SMYD3

chr1:246518332

chr1:246720836

ENST00000490107

49_87

370.0

Zinc finger

MYND-type

Hgene

SMYD3

chr1:246518332

chr1:246720836

ENST00000541742

49_87

370.0

Zinc finger

MYND-type

Hgene

SMYD3

chr1:246670356

chr1:246711909

ENST00000388985

49_87

429.0

Zinc finger

MYND-type

Hgene

SMYD3

chr1:246670356

chr1:246711909

ENST00000490107

49_87

370.0

Zinc finger

MYND-type

Hgene

SMYD3

chr1:246670356

chr1:246711909

ENST00000541742

49_87

370.0

Zinc finger

MYND-type

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Fusion Gene Sequence for SMYD3-TFB2M

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>84384_84384_1_SMYD3-TFB2M_SMYD3_chr1_246518332_ENST00000388985_TFB2M_chr1_246720836_ENST00000366514_length(transcript)=1488nt_BP=228nt
ATGGAGCCGCTGAAGGTGGAAAAGTTCGCAACCGCCAAGAGGGGAAACGGGCTGCGCGCCGTGACCCCGCTGCGCCCCGGAGAGCTACTC
TTCCGCTCGGATCCCTTGGCGTACACGGTGTGCAAGGGGAGTCGTGGCGTCGTCTGCGACCGCTGCCTTCTCGGGAAGGAAAAGCTGATG
CGATGCTCTCAGTGCCGCGTCGCCAAATACTGTAGTGCTAAGTGTCAGTCCTTAGGAAAAAATCTGGATGGAAAACTACGAGTGATCCAC
TGTGACTTCTTTAAACTAGATCCTAGAAGTGGTGGAGTAATAAAACCACCTGCTATGTCTTCTCGAGGGCTCTTTAAGAATTTGGGAATA
GAAGCAGTTCCTTGGACAGCAGACATCCCTTTAAAAGTAGTTGGAATGTTCCCAAGTAGAGGTGAGAAAAGGGCACTTTGGAAACTCGCA
TATGACTTGTATTCCTGTACTTCTATATATAAATTTGGACGAATAGAAGTAAATATGTTTATTGGTGAAAAAGAATTCCAGAAACTAATG
GCAGATCCCGGAAATCCAGACTTGTATCATGTATTAAGTGTTATCTGGCAATTAGCTTGTGAGATTAAGGTTCTGCACATGGAGCCTTGG
TCATCATTTGATATATACACCCGGAAAGGGCCGCTGGAAAACCCAAAGCGTAGGGAATTATTAGACCAATTACAACAAAAGCTGTATCTT
ATTCAAATGATTCCTCGTCAAAATTTATTTACCAAGAACTTAACACCTATGAACTATAATATATTTTTTCACTTGTTAAAGCACTGTTTT
GGGAGGCGCAGCGCCACTGTAATAGACCACTTACGTTCATTGACTCCACTTGATGCGAGAGATATATTGATGCAAATAGGAAAACAGGAG
GATGAGAAAGTAGTTAACATGCACCCTCAAGACTTCAAAACACTTTTTGAAACTATAGAGCGTTCCAAAGATTGTGCTTATAAATGGCTG
TATGATGAAACCCTGGAAGATAGGTAGCAACTAGACTGTCGTTTTTGGTGGAGCGGTTCATTTATTTGGAAACTATGACATGAAAACCAA
ATTTGAAAACTCACATCCTTTCAGCAGAAGGTAACTGTTCTTGTCTTGCACAAGCCAGGCAGATCATTTCTCCTAAGCTGATATCATTGG
CTTATTGGATGAAACAGTGTCTGCTATTTTATTCACAATTGAATAAAATGAAAACTTCAATTAATTGTGGATTTGATCAGATTGAATTCG
TTTTGTTTCAGATTCCTATTTAAATATTTCACTTGTACTGTTGCTGATTTTTGCATCTTCTTGAAGAGCAAGAGTCTGTACATTATTAAG
CTTAGAAAGTAAGCAAAACTGATTTACTGGTTTGCCTTTCAGTTTGTTGAAATGTATTGTCAAGTACTGTACAATGAAATTGTTTAAATT
TTAATATGATTTAAGCTTTTTAGAAATTAAAATATTTTAAATAAGAAG

>84384_84384_1_SMYD3-TFB2M_SMYD3_chr1_246518332_ENST00000388985_TFB2M_chr1_246720836_ENST00000366514_length(amino acids)=338AA_BP=76
MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKCQSLGKNLDGKLRVIH
CDFFKLDPRSGGVIKPPAMSSRGLFKNLGIEAVPWTADIPLKVVGMFPSRGEKRALWKLAYDLYSCTSIYKFGRIEVNMFIGEKEFQKLM
ADPGNPDLYHVLSVIWQLACEIKVLHMEPWSSFDIYTRKGPLENPKRRELLDQLQQKLYLIQMIPRQNLFTKNLTPMNYNIFFHLLKHCF
GRRSATVIDHLRSLTPLDARDILMQIGKQEDEKVVNMHPQDFKTLFETIERSKDCAYKWLYDETLEDR

--------------------------------------------------------------
>84384_84384_2_SMYD3-TFB2M_SMYD3_chr1_246518332_ENST00000403792_TFB2M_chr1_246720836_ENST00000366514_length(transcript)=1583nt_BP=323nt
GTGCGCGCAGGGCGCAGGCGCGCGGGTCCCGGCAGCCCGTGAGACGCCCGCTGCTGGACGCGGGTAGCCGTCTGAGGTGCCGGAGCTGCG
GGAGGATGGAGCCGCTGAAGGTGGAAAAGTTCGCAACCGCCAAGAGGGGAAACGGGCTGCGCGCCGTGACCCCGCTGCGCCCCGGAGAGC
TACTCTTCCGCTCGGATCCCTTGGCGTACACGGTGTGCAAGGGGAGTCGTGGCGTCGTCTGCGACCGCTGCCTTCTCGGGAAGGAAAAGC
TGATGCGATGCTCTCAGTGCCGCGTCGCCAAATACTGTAGTGCTAAGTGTCAGTCCTTAGGAAAAAATCTGGATGGAAAACTACGAGTGA
TCCACTGTGACTTCTTTAAACTAGATCCTAGAAGTGGTGGAGTAATAAAACCACCTGCTATGTCTTCTCGAGGGCTCTTTAAGAATTTGG
GAATAGAAGCAGTTCCTTGGACAGCAGACATCCCTTTAAAAGTAGTTGGAATGTTCCCAAGTAGAGGTGAGAAAAGGGCACTTTGGAAAC
TCGCATATGACTTGTATTCCTGTACTTCTATATATAAATTTGGACGAATAGAAGTAAATATGTTTATTGGTGAAAAAGAATTCCAGAAAC
TAATGGCAGATCCCGGAAATCCAGACTTGTATCATGTATTAAGTGTTATCTGGCAATTAGCTTGTGAGATTAAGGTTCTGCACATGGAGC
CTTGGTCATCATTTGATATATACACCCGGAAAGGGCCGCTGGAAAACCCAAAGCGTAGGGAATTATTAGACCAATTACAACAAAAGCTGT
ATCTTATTCAAATGATTCCTCGTCAAAATTTATTTACCAAGAACTTAACACCTATGAACTATAATATATTTTTTCACTTGTTAAAGCACT
GTTTTGGGAGGCGCAGCGCCACTGTAATAGACCACTTACGTTCATTGACTCCACTTGATGCGAGAGATATATTGATGCAAATAGGAAAAC
AGGAGGATGAGAAAGTAGTTAACATGCACCCTCAAGACTTCAAAACACTTTTTGAAACTATAGAGCGTTCCAAAGATTGTGCTTATAAAT
GGCTGTATGATGAAACCCTGGAAGATAGGTAGCAACTAGACTGTCGTTTTTGGTGGAGCGGTTCATTTATTTGGAAACTATGACATGAAA
ACCAAATTTGAAAACTCACATCCTTTCAGCAGAAGGTAACTGTTCTTGTCTTGCACAAGCCAGGCAGATCATTTCTCCTAAGCTGATATC
ATTGGCTTATTGGATGAAACAGTGTCTGCTATTTTATTCACAATTGAATAAAATGAAAACTTCAATTAATTGTGGATTTGATCAGATTGA
ATTCGTTTTGTTTCAGATTCCTATTTAAATATTTCACTTGTACTGTTGCTGATTTTTGCATCTTCTTGAAGAGCAAGAGTCTGTACATTA
TTAAGCTTAGAAAGTAAGCAAAACTGATTTACTGGTTTGCCTTTCAGTTTGTTGAAATGTATTGTCAAGTACTGTACAATGAAATTGTTT
AAATTTTAATATGATTTAAGCTTTTTAGAAATTAAAATATTTTAAATAAGAAG

>84384_84384_2_SMYD3-TFB2M_SMYD3_chr1_246518332_ENST00000403792_TFB2M_chr1_246720836_ENST00000366514_length(amino acids)=353AA_BP=91
MLDAGSRLRCRSCGRMEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKC
QSLGKNLDGKLRVIHCDFFKLDPRSGGVIKPPAMSSRGLFKNLGIEAVPWTADIPLKVVGMFPSRGEKRALWKLAYDLYSCTSIYKFGRI
EVNMFIGEKEFQKLMADPGNPDLYHVLSVIWQLACEIKVLHMEPWSSFDIYTRKGPLENPKRRELLDQLQQKLYLIQMIPRQNLFTKNLT
PMNYNIFFHLLKHCFGRRSATVIDHLRSLTPLDARDILMQIGKQEDEKVVNMHPQDFKTLFETIERSKDCAYKWLYDETLEDR

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>84384_84384_3_SMYD3-TFB2M_SMYD3_chr1_246518332_ENST00000490107_TFB2M_chr1_246720836_ENST00000366514_length(transcript)=1528nt_BP=268nt
GGACGCGGGTAGCCGTCTGAGGTGCCGGAGCTGCGGGAGGATGGAGCCGCTGAAGGTGGAAAAGTTCGCAACCGCCAAGAGGGGAAACGG
GCTGCGCGCCGTGACCCCGCTGCGCCCCGGAGAGCTACTCTTCCGCTCGGATCCCTTGGCGTACACGGTGTGCAAGGGGAGTCGTGGCGT
CGTCTGCGACCGCTGCCTTCTCGGGAAGGAAAAGCTGATGCGATGCTCTCAGTGCCGCGTCGCCAAATACTGTAGTGCTAAGTGTCAGTC
CTTAGGAAAAAATCTGGATGGAAAACTACGAGTGATCCACTGTGACTTCTTTAAACTAGATCCTAGAAGTGGTGGAGTAATAAAACCACC
TGCTATGTCTTCTCGAGGGCTCTTTAAGAATTTGGGAATAGAAGCAGTTCCTTGGACAGCAGACATCCCTTTAAAAGTAGTTGGAATGTT
CCCAAGTAGAGGTGAGAAAAGGGCACTTTGGAAACTCGCATATGACTTGTATTCCTGTACTTCTATATATAAATTTGGACGAATAGAAGT
AAATATGTTTATTGGTGAAAAAGAATTCCAGAAACTAATGGCAGATCCCGGAAATCCAGACTTGTATCATGTATTAAGTGTTATCTGGCA
ATTAGCTTGTGAGATTAAGGTTCTGCACATGGAGCCTTGGTCATCATTTGATATATACACCCGGAAAGGGCCGCTGGAAAACCCAAAGCG
TAGGGAATTATTAGACCAATTACAACAAAAGCTGTATCTTATTCAAATGATTCCTCGTCAAAATTTATTTACCAAGAACTTAACACCTAT
GAACTATAATATATTTTTTCACTTGTTAAAGCACTGTTTTGGGAGGCGCAGCGCCACTGTAATAGACCACTTACGTTCATTGACTCCACT
TGATGCGAGAGATATATTGATGCAAATAGGAAAACAGGAGGATGAGAAAGTAGTTAACATGCACCCTCAAGACTTCAAAACACTTTTTGA
AACTATAGAGCGTTCCAAAGATTGTGCTTATAAATGGCTGTATGATGAAACCCTGGAAGATAGGTAGCAACTAGACTGTCGTTTTTGGTG
GAGCGGTTCATTTATTTGGAAACTATGACATGAAAACCAAATTTGAAAACTCACATCCTTTCAGCAGAAGGTAACTGTTCTTGTCTTGCA
CAAGCCAGGCAGATCATTTCTCCTAAGCTGATATCATTGGCTTATTGGATGAAACAGTGTCTGCTATTTTATTCACAATTGAATAAAATG
AAAACTTCAATTAATTGTGGATTTGATCAGATTGAATTCGTTTTGTTTCAGATTCCTATTTAAATATTTCACTTGTACTGTTGCTGATTT
TTGCATCTTCTTGAAGAGCAAGAGTCTGTACATTATTAAGCTTAGAAAGTAAGCAAAACTGATTTACTGGTTTGCCTTTCAGTTTGTTGA
AATGTATTGTCAAGTACTGTACAATGAAATTGTTTAAATTTTAATATGATTTAAGCTTTTTAGAAATTAAAATATTTTAAATAAGAAG

>84384_84384_3_SMYD3-TFB2M_SMYD3_chr1_246518332_ENST00000490107_TFB2M_chr1_246720836_ENST00000366514_length(amino acids)=346AA_BP=84
MRCRSCGRMEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKCQSLGKNL
DGKLRVIHCDFFKLDPRSGGVIKPPAMSSRGLFKNLGIEAVPWTADIPLKVVGMFPSRGEKRALWKLAYDLYSCTSIYKFGRIEVNMFIG
EKEFQKLMADPGNPDLYHVLSVIWQLACEIKVLHMEPWSSFDIYTRKGPLENPKRRELLDQLQQKLYLIQMIPRQNLFTKNLTPMNYNIF
FHLLKHCFGRRSATVIDHLRSLTPLDARDILMQIGKQEDEKVVNMHPQDFKTLFETIERSKDCAYKWLYDETLEDR

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Fusion Gene PPI Analysis for SMYD3-TFB2M

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for SMYD3-TFB2M

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for SMYD3-TFB2M

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	SMYD3	C0236733	Amphetamine-Related Disorders	1	CTD_human
Hgene	SMYD3	C0236804	Amphetamine Addiction	1	CTD_human
Hgene	SMYD3	C0236807	Amphetamine Abuse	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:SMYD3-TFB2M (FusionGDB2 ID:HG64754TG64216)

Fusion Gene Summary for SMYD3-TFB2M

Fusion Gene ORF analysis for SMYD3-TFB2M

Fusion Genomic Features for SMYD3-TFB2M

Fusion Protein Features for SMYD3-TFB2M

Fusion Gene Sequence for SMYD3-TFB2M

Fusion Gene PPI Analysis for SMYD3-TFB2M

Related Drugs for SMYD3-TFB2M

Related Diseases for SMYD3-TFB2M

Fusion Gene Studies
in Kim Lab