Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:CEP85-CLIC4 (FusionGDB2 ID:HG64793TG25932)

Fusion Gene Summary for CEP85-CLIC4

check button Fusion gene summary
Fusion gene informationFusion gene name: CEP85-CLIC4
Fusion gene ID: hg64793tg25932
HgeneTgene
Gene symbol

CEP85

CLIC4

Gene ID

64793

25932

Gene namecentrosomal protein 85chloride intracellular channel 4
SynonymsCCDC21CLIC4L|H1|MTCLIC|huH1|p64H1
Cytomap('CEP85')('CLIC4')

1p36.11

1p36.11

Type of geneprotein-codingprotein-coding
Descriptioncentrosomal protein of 85 kDacentrosomal protein 85kDacoiled-coil domain-containing protein 21chloride intracellular channel protein 4chloride intracellular channel 4 likeepididymis secretory sperm binding proteinintracellular chloride ion channel protein p64H1
Modification date2020032020200313
UniProtAcc.

Q9Y696

Ensembl transtripts involved in fusion geneENST00000252992, ENST00000451429, 
ENST00000469609, 
Fusion gene scores* DoF score5 X 4 X 5=10012 X 10 X 5=600
# samples 512
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(12/600*10)=-2.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CEP85 [Title/Abstract] AND CLIC4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCEP85(26566329)-CLIC4(25166351), # samples:2
Anticipated loss of major functional domain due to fusion event.CEP85-CLIC4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CEP85-CLIC4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCLIC4

GO:0030336

negative regulation of cell migration

12163372


check buttonFusion gene breakpoints across CEP85 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CLIC4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-DD-AACD-01ACEP85chr1

26566329

+CLIC4chr1

25166351

+
ChimerDB4LIHCTCGA-DD-AACDCEP85chr1

26566329

+CLIC4chr1

25166351

+


Top

Fusion Gene ORF analysis for CEP85-CLIC4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000252992ENST00000497755CEP85chr1

26566329

+CLIC4chr1

25166351

+
5CDS-3UTRENST00000451429ENST00000497755CEP85chr1

26566329

+CLIC4chr1

25166351

+
In-frameENST00000252992ENST00000374379CEP85chr1

26566329

+CLIC4chr1

25166351

+
In-frameENST00000451429ENST00000374379CEP85chr1

26566329

+CLIC4chr1

25166351

+
intron-3CDSENST00000469609ENST00000374379CEP85chr1

26566329

+CLIC4chr1

25166351

+
intron-3UTRENST00000469609ENST00000497755CEP85chr1

26566329

+CLIC4chr1

25166351

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000451429CEP85chr126566329+ENST00000374379CLIC4chr125166351+392218834052962147
ENST00000252992CEP85chr126566329+ENST00000374379CLIC4chr125166351+392018634032960147

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000451429ENST00000374379CEP85chr126566329+CLIC4chr125166351+0.0049296170.99507046
ENST00000252992ENST00000374379CEP85chr126566329+CLIC4chr125166351+0.0049329670.995067

Top

Fusion Genomic Features for CEP85-CLIC4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CEP85chr126566329+CLIC4chr125166350+1.22E-101
CEP85chr126566329+CLIC4chr125166350+1.22E-101
CEP85chr126566329+CLIC4chr125166350+1.22E-101
CEP85chr126566329+CLIC4chr125166350+1.22E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for CEP85-CLIC4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:26566329/chr1:25166351)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CLIC4

Q9Y696

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). {ECO:0000269|PubMed:12163372, ECO:0000269|PubMed:14569596, ECO:0000269|PubMed:16176272, ECO:0000269|PubMed:16239224, ECO:0000269|PubMed:18302930, ECO:0000269|PubMed:19247789}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCEP85chr1:26566329chr1:25166351ENST00000252992+214334_65718763.0Coiled coilOntology_term=ECO:0000255
HgeneCEP85chr1:26566329chr1:25166351ENST00000252992+214723_75018763.0Coiled coilOntology_term=ECO:0000255
HgeneCEP85chr1:26566329chr1:25166351ENST00000252992+214434_47618763.0RegionRequired for centrosome localization and for its function in the suppression of centrosome disjunction
TgeneCLIC4chr1:26566329chr1:25166351ENST0000037437936104_244138254.0DomainNote=GST C-terminal
TgeneCLIC4chr1:26566329chr1:25166351ENST00000374379362_101138254.0RegionRequired for insertion into the membrane
TgeneCLIC4chr1:26566329chr1:25166351ENST000003743793637_57138254.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane


Top

Fusion Gene Sequence for CEP85-CLIC4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>15906_15906_1_CEP85-CLIC4_CEP85_chr1_26566329_ENST00000252992_CLIC4_chr1_25166351_ENST00000374379_length(transcript)=3920nt_BP=186nt
GCAACGGCCGTTAGAGGAGCTGAGGGAGGGAACCACCGCTCACCGCAGACGTGGTGGCTGCAGTCAGTCTTCCCGAGTGAGGGATTTCGC
CGCCCGCTTTCAGGCCCGTTTGGCTTAAATAACTGTGATTGATGGCCATGCAGGAGAAATATCCAACTGAGGGGATCTCTCACGTCACTT
CACCGACACTGGAGAGGGGTCTCCTGAAAACCCTGCAGAAACTGGATGAATATCTGAATTCTCCTCTCCCTGATGAAATTGATGAAAATA
GTATGGAGGACATAAAGTTTTCTACACGTAAATTTCTGGATGGCAATGAAATGACATTAGCTGATTGCAACCTGCTGCCCAAACTGCATA
TTGTCAAGGTGGTGGCCAAAAAATATCGCAACTTTGATATTCCAAAAGAAATGACTGGCATCTGGAGATACCTAACTAATGCATACAGTA
GGGACGAGTTCACCAATACCTGTCCCAGTGATAAGGAGGTTGAAATAGCATATAGTGATGTAGCCAAAAGACTCACCAAGTAAAATCGCG
TTTGTAAAAGAGATGTCTTCATGTCTTCCCCTAAGAATACGCTTTTCCTAACAGGCTACTCCTTCCTGTAGAGCAGAAATTGTATTTTGC
ACGAACATGCAGTTATTGAAGATTAGGATCAAGGATAGACAAGGTATAGTAGTTATCTTAAAATATACACTCCTAAGCAGTATTATTTTA
AAATCCTTTACCCTGGCTACCTCCCCTACCCGGGTTCCCCTCTCTTTAATTTGGAGACACTCCACCACAAACTTTTCACTTTAGAGGTAG
CTTGCCATCTCTCAGGAGCCCTCACCATTGTGTCCATTCACTGTGTATAGATGGCAGAACTTTTGAGGTGCAATGTTTAATTGTTAAAAA
TAGTAGCCACGACTTTATCAGGCAGCCCCAAACTGGTGCATAATGCATGGTACAAGAAATATTTATGTATTTTTTGGAATTTTGTAATAT
TTAGTAAGAGTATATGAAAGGATTGCTACTGTATCAGAAATATTGTTTCAATTTAGTCTATCCTGGATATGTACTAACGAATATTACCAC
CAGAGAAGAGAGCTTTCTACAAAAGTCACTACAGATTTTGCTATATTGCTTTGTAGATAGATTTTTACTTTTGCCTAAAAGCATTTATCC
TTCATACCAATTGTAACATCTGACACCATGTAGAAGCTAAAAGTTTAGAGGGAGTGAGGGTTTTCTCAAGACCTTCCTCAAGCATTTTAT
CTTTAGAAGAGAAACTGATGGGCACCTGATACTCTGTCTAAATACGTTTGTTATATGTGTTTTGCCCTGTGCCATTCATTTGGAACTTTA
TTGCATTCTTTATTTTAAAAAGCTTGTTTTTACGTAATCATAGAGCTTGCTATTTGTACATCTGTTGAGCAACACTACATAACTGATTTT
TAGTTGACTTAGCTATAGCAGTACAATGATTAGTAATGTAAAAATTAACACAGAAATTAACCTAAGGAATGAAGGGTGGGTTTGTCAAAA
TATCAAGTAAATTTTTGTTTCTAAAGTACATTTAATGTAGATGACCTAAAGAATGCGTTATCCATCCTATATAAAAGAAAGATAAAACAC
AGGTCACCAATTTTCTCATTTCACCCCATTTACCTTGTATAGAGGATTGTTCATTCCTTTGGGACTAAGTTATAGTTATGGTGAGTGTGT
ATTTACTGTAGTTTTGCCTGATCTCACTCATTGCACTTCCTGGAGTTAAATTTTCCAACAGCCATGTTGAGGAATAGCACTCTGCATGTT
TTTGTTTTGTTTTTCGGGGTTTTTTTTAATTGAAGCCCTAAACCAGGAATTATTTGTGTTCTAACAGGAGGATGAACTTGCTGAAAATAA
AACTTTGCTATGTATTTACTCTTTTTTAAAAGACAAAAGCAAAACCAGACTTTCTACGTACTACTCCAAAGACTGTGATTGTGACTATAA
TACATTTTTGGTAATTTTTTTATACCTAATTTGTATAGGAAGTGCTATTTCTCATAGGCTGTTTCTTGAAATTTTAAGTTTATTGCTTTA
AAATGGCAGTGTTTCTCCCACTTTGATATGCTAACATTTAGTAAGCACTGGCTTTATGAAAGCGGCTTTTTATAAGTATACTGCATTTTT
TGAGCCTATCATTAATTAGCTTAGTATGAAAGATAAGAAAATCTCCATGTTGTATCCATTTGGCTCAGGAAGATTCTTTGCCTTACCTTT
CTTAGAACTCTTTATTGCTTATCAAAAGTTTGAGTACCCGCTTGGTTTTTTTTTGGTAATTAAATATTGTATGATTTATCTGGTTCAAGG
AAGATGCACTATTCAGTTATCTATTGAGAAATTATTTTGCAGTGGTTTTAGTGGGTGAAAATGTCCCATCTGCACCAGTACACAGGCAGG
CATTATCATTCTTCACCTACTTTTTAAATAGTGGCAACTTGGGATTCATTCTGGTGATTCTGAACCTTGCCTCATAGCTTAAAGTATAAA
AAAGATTCAAGAGCAGTGAGGTTTGTTCTTTCCAGTGAATGGTGGACTGAGTGGTGCGAGGTGGAGGGCTAACAAGAGGAAAGAACTACA
TTCTTCAGAATACAGTGATGAAAATTCATTTTGAAACTCAAATATTTTCATTTTGGATATTCTCCTGTTTTTATTAAACCAGTGATTACA
CCTGGCCATCCCTCTAAATGTTCTAGGAAGGCATGTCTATTGTGATTTTGATGAAGACAGAATTATTTTTCTCTGTAGAAACACAGATAC
CACTTTATCAGGGAAGTTAGTCAAATGAAATGGAAATTGGTAAATGGACAAAAGCTAGCTAGTAAAAAGGACGACCCAGCAACATGCTTT
AACCCCATTGTATGTTTGTGGAAAGAGCATAGTTTAACATCTTGAGAAATTTGGGACATAAAGTTTTCATGGTAGACAGTTCATGCAGTA
TATGAATTGCCATAATGGAAATAATCTGATTTTATTTTTACAACTAACATCCATTCCCCTTCATTTAAACACCTTTTGTGTTTTACTTCA
GTGAGGAGATTGGAGTCTGAATGGATCTGTTTTCCAAGAGATTCTGAGAAATTTTTGTATTCAGCAGTTGGAAAGCTCTCTATTCTAGTT
GATAAAACTTCCCTTTTTTGATGTAGATGCAGATATTCTATACAGTTCTGTTGTCTTTTACTAGGACTGTAAACTTTTGTGATAAAATTC
AAATAAGATTTTATTTCTTGGTAATTTTGGCTTTCACAATTTATCTTTAAATCCTTGAGCAATCTGTATACAATTAAGAGATTTCTGACA
TTTATTCTTACACTAAATGGATCAACTCTAGGATTTAGGCATGTTAACTTCTGTTGTGTTTTGAATCTCTCCAGAGTTGCATGTAGATAG
CATTTATTTCTGTGCCCTTAAACCCATTTAGAAAATAACTACAAAGTAAAAATGTAGAGGAAATAGAAATGTATTTTTTCATGAACATTT
TGATACAAATTTCATCATTTAATGATTCACCAATTTCTTGCATTAATTTGAATTTAAGCATTTAATTCAAAGAGAGGGGAGCATCCATTA
TTGATACATGTGGGCTTTTAAAAACTCCATCCTTTATAAATAGTCAAGGTTTGGGCCACACAAAGTATATTTTTATCATGGAAAAATTTC
AACTCCTCAAGCCGTAATGTTGAACAGAATTGGAGTATTTTCTTTATAATTTCTTGAACAGGCAAATGAAAGCTTATTATAGAATGCATG
TATTTTCTTTTATCTTTGGAACATCAGCACCAGTATATTGCTGGCAGCTATTGTATTAAAAAATAAAGTATATTTTCACTATCATAAAGG

>15906_15906_1_CEP85-CLIC4_CEP85_chr1_26566329_ENST00000252992_CLIC4_chr1_25166351_ENST00000374379_length(amino acids)=147AA_BP=
MERFKTQQKLTCLNPRVDPFSVRINVRNLLIVYRLLKDLKINCESQNYQEIKSYLNFITKVYSPSKRQQNCIEYLHLHQKREVLSTRIES

--------------------------------------------------------------
>15906_15906_2_CEP85-CLIC4_CEP85_chr1_26566329_ENST00000451429_CLIC4_chr1_25166351_ENST00000374379_length(transcript)=3922nt_BP=188nt
GTGCAACGGCCGTTAGAGGAGCTGAGGGAGGGAACCACCGCTCACCGCAGACGTGGTGGCTGCAGTCAGTCTTCCCGAGTGAGGGATTTC
GCCGCCCGCTTTCAGGCCCGTTTGGCTTAAATAACTGTGATTGATGGCCATGCAGGAGAAATATCCAACTGAGGGGATCTCTCACGTCAC
TTCACCGACACTGGAGAGGGGTCTCCTGAAAACCCTGCAGAAACTGGATGAATATCTGAATTCTCCTCTCCCTGATGAAATTGATGAAAA
TAGTATGGAGGACATAAAGTTTTCTACACGTAAATTTCTGGATGGCAATGAAATGACATTAGCTGATTGCAACCTGCTGCCCAAACTGCA
TATTGTCAAGGTGGTGGCCAAAAAATATCGCAACTTTGATATTCCAAAAGAAATGACTGGCATCTGGAGATACCTAACTAATGCATACAG
TAGGGACGAGTTCACCAATACCTGTCCCAGTGATAAGGAGGTTGAAATAGCATATAGTGATGTAGCCAAAAGACTCACCAAGTAAAATCG
CGTTTGTAAAAGAGATGTCTTCATGTCTTCCCCTAAGAATACGCTTTTCCTAACAGGCTACTCCTTCCTGTAGAGCAGAAATTGTATTTT
GCACGAACATGCAGTTATTGAAGATTAGGATCAAGGATAGACAAGGTATAGTAGTTATCTTAAAATATACACTCCTAAGCAGTATTATTT
TAAAATCCTTTACCCTGGCTACCTCCCCTACCCGGGTTCCCCTCTCTTTAATTTGGAGACACTCCACCACAAACTTTTCACTTTAGAGGT
AGCTTGCCATCTCTCAGGAGCCCTCACCATTGTGTCCATTCACTGTGTATAGATGGCAGAACTTTTGAGGTGCAATGTTTAATTGTTAAA
AATAGTAGCCACGACTTTATCAGGCAGCCCCAAACTGGTGCATAATGCATGGTACAAGAAATATTTATGTATTTTTTGGAATTTTGTAAT
ATTTAGTAAGAGTATATGAAAGGATTGCTACTGTATCAGAAATATTGTTTCAATTTAGTCTATCCTGGATATGTACTAACGAATATTACC
ACCAGAGAAGAGAGCTTTCTACAAAAGTCACTACAGATTTTGCTATATTGCTTTGTAGATAGATTTTTACTTTTGCCTAAAAGCATTTAT
CCTTCATACCAATTGTAACATCTGACACCATGTAGAAGCTAAAAGTTTAGAGGGAGTGAGGGTTTTCTCAAGACCTTCCTCAAGCATTTT
ATCTTTAGAAGAGAAACTGATGGGCACCTGATACTCTGTCTAAATACGTTTGTTATATGTGTTTTGCCCTGTGCCATTCATTTGGAACTT
TATTGCATTCTTTATTTTAAAAAGCTTGTTTTTACGTAATCATAGAGCTTGCTATTTGTACATCTGTTGAGCAACACTACATAACTGATT
TTTAGTTGACTTAGCTATAGCAGTACAATGATTAGTAATGTAAAAATTAACACAGAAATTAACCTAAGGAATGAAGGGTGGGTTTGTCAA
AATATCAAGTAAATTTTTGTTTCTAAAGTACATTTAATGTAGATGACCTAAAGAATGCGTTATCCATCCTATATAAAAGAAAGATAAAAC
ACAGGTCACCAATTTTCTCATTTCACCCCATTTACCTTGTATAGAGGATTGTTCATTCCTTTGGGACTAAGTTATAGTTATGGTGAGTGT
GTATTTACTGTAGTTTTGCCTGATCTCACTCATTGCACTTCCTGGAGTTAAATTTTCCAACAGCCATGTTGAGGAATAGCACTCTGCATG
TTTTTGTTTTGTTTTTCGGGGTTTTTTTTAATTGAAGCCCTAAACCAGGAATTATTTGTGTTCTAACAGGAGGATGAACTTGCTGAAAAT
AAAACTTTGCTATGTATTTACTCTTTTTTAAAAGACAAAAGCAAAACCAGACTTTCTACGTACTACTCCAAAGACTGTGATTGTGACTAT
AATACATTTTTGGTAATTTTTTTATACCTAATTTGTATAGGAAGTGCTATTTCTCATAGGCTGTTTCTTGAAATTTTAAGTTTATTGCTT
TAAAATGGCAGTGTTTCTCCCACTTTGATATGCTAACATTTAGTAAGCACTGGCTTTATGAAAGCGGCTTTTTATAAGTATACTGCATTT
TTTGAGCCTATCATTAATTAGCTTAGTATGAAAGATAAGAAAATCTCCATGTTGTATCCATTTGGCTCAGGAAGATTCTTTGCCTTACCT
TTCTTAGAACTCTTTATTGCTTATCAAAAGTTTGAGTACCCGCTTGGTTTTTTTTTGGTAATTAAATATTGTATGATTTATCTGGTTCAA
GGAAGATGCACTATTCAGTTATCTATTGAGAAATTATTTTGCAGTGGTTTTAGTGGGTGAAAATGTCCCATCTGCACCAGTACACAGGCA
GGCATTATCATTCTTCACCTACTTTTTAAATAGTGGCAACTTGGGATTCATTCTGGTGATTCTGAACCTTGCCTCATAGCTTAAAGTATA
AAAAAGATTCAAGAGCAGTGAGGTTTGTTCTTTCCAGTGAATGGTGGACTGAGTGGTGCGAGGTGGAGGGCTAACAAGAGGAAAGAACTA
CATTCTTCAGAATACAGTGATGAAAATTCATTTTGAAACTCAAATATTTTCATTTTGGATATTCTCCTGTTTTTATTAAACCAGTGATTA
CACCTGGCCATCCCTCTAAATGTTCTAGGAAGGCATGTCTATTGTGATTTTGATGAAGACAGAATTATTTTTCTCTGTAGAAACACAGAT
ACCACTTTATCAGGGAAGTTAGTCAAATGAAATGGAAATTGGTAAATGGACAAAAGCTAGCTAGTAAAAAGGACGACCCAGCAACATGCT
TTAACCCCATTGTATGTTTGTGGAAAGAGCATAGTTTAACATCTTGAGAAATTTGGGACATAAAGTTTTCATGGTAGACAGTTCATGCAG
TATATGAATTGCCATAATGGAAATAATCTGATTTTATTTTTACAACTAACATCCATTCCCCTTCATTTAAACACCTTTTGTGTTTTACTT
CAGTGAGGAGATTGGAGTCTGAATGGATCTGTTTTCCAAGAGATTCTGAGAAATTTTTGTATTCAGCAGTTGGAAAGCTCTCTATTCTAG
TTGATAAAACTTCCCTTTTTTGATGTAGATGCAGATATTCTATACAGTTCTGTTGTCTTTTACTAGGACTGTAAACTTTTGTGATAAAAT
TCAAATAAGATTTTATTTCTTGGTAATTTTGGCTTTCACAATTTATCTTTAAATCCTTGAGCAATCTGTATACAATTAAGAGATTTCTGA
CATTTATTCTTACACTAAATGGATCAACTCTAGGATTTAGGCATGTTAACTTCTGTTGTGTTTTGAATCTCTCCAGAGTTGCATGTAGAT
AGCATTTATTTCTGTGCCCTTAAACCCATTTAGAAAATAACTACAAAGTAAAAATGTAGAGGAAATAGAAATGTATTTTTTCATGAACAT
TTTGATACAAATTTCATCATTTAATGATTCACCAATTTCTTGCATTAATTTGAATTTAAGCATTTAATTCAAAGAGAGGGGAGCATCCAT
TATTGATACATGTGGGCTTTTAAAAACTCCATCCTTTATAAATAGTCAAGGTTTGGGCCACACAAAGTATATTTTTATCATGGAAAAATT
TCAACTCCTCAAGCCGTAATGTTGAACAGAATTGGAGTATTTTCTTTATAATTTCTTGAACAGGCAAATGAAAGCTTATTATAGAATGCA
TGTATTTTCTTTTATCTTTGGAACATCAGCACCAGTATATTGCTGGCAGCTATTGTATTAAAAAATAAAGTATATTTTCACTATCATAAA

>15906_15906_2_CEP85-CLIC4_CEP85_chr1_26566329_ENST00000451429_CLIC4_chr1_25166351_ENST00000374379_length(amino acids)=147AA_BP=
MERFKTQQKLTCLNPRVDPFSVRINVRNLLIVYRLLKDLKINCESQNYQEIKSYLNFITKVYSPSKRQQNCIEYLHLHQKREVLSTRIES

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CEP85-CLIC4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for CEP85-CLIC4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for CEP85-CLIC4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0029408Degenerative polyarthritis1CTD_human
TgeneC0033578Prostatic Neoplasms1CTD_human
TgeneC0043094Weight Gain1CTD_human
TgeneC0086743Osteoarthrosis Deformans1CTD_human
TgeneC0376358Malignant neoplasm of prostate1CTD_human