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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:BMP7-PARP1 (FusionGDB2 ID:HG655TG142) |
Fusion Gene Summary for BMP7-PARP1 |
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Fusion gene information | Fusion gene name: BMP7-PARP1 | Fusion gene ID: hg655tg142 | Hgene | Tgene | Gene symbol | BMP7 | PARP1 | Gene ID | 655 | 142 |
Gene name | bone morphogenetic protein 7 | poly(ADP-ribose) polymerase 1 | |
Synonyms | OP-1 | ADPRT|ADPRT 1|ADPRT1|ARTD1|PARP|PARP-1|PPOL|pADPRT-1 | |
Cytomap | ('BMP7')('PARP1') 20q13.31 | 1q42.12 | |
Type of gene | protein-coding | protein-coding | |
Description | bone morphogenetic protein 7osteogenic protein 1 | poly [ADP-ribose] polymerase 1ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)ADP-ribosyltransferase NAD(+)ADP-ribosyltransferase diphtheria toxin-like 1DNA ADP-ribosyltransferase PARP1NAD(+) ADP-ribosyltransferase 1poly (ADP-ribose) poly | |
Modification date | 20200327 | 20200329 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000395863, ENST00000395864, ENST00000450594, ENST00000460817, | ||
Fusion gene scores | * DoF score | 11 X 10 X 6=660 | 12 X 10 X 9=1080 |
# samples | 13 | 12 | |
** MAII score | log2(13/660*10)=-2.34395440121736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/1080*10)=-3.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: BMP7 [Title/Abstract] AND PARP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | BMP7(55749986)-PARP1(226579082), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | BMP7 | GO:0010628 | positive regulation of gene expression | 28124060 |
Hgene | BMP7 | GO:0010800 | positive regulation of peptidyl-threonine phosphorylation | 19736306 |
Hgene | BMP7 | GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation | 9311995|16049014|17244894|19736306 |
Hgene | BMP7 | GO:0030501 | positive regulation of bone mineralization | 18436533 |
Hgene | BMP7 | GO:0030509 | BMP signaling pathway | 16049014|18436533 |
Hgene | BMP7 | GO:0034116 | positive regulation of heterotypic cell-cell adhesion | 15100360 |
Hgene | BMP7 | GO:0034504 | protein localization to nucleus | 17244894 |
Hgene | BMP7 | GO:0042326 | negative regulation of phosphorylation | 17244894 |
Hgene | BMP7 | GO:0043407 | negative regulation of MAP kinase activity | 17244894 |
Hgene | BMP7 | GO:0045665 | negative regulation of neuron differentiation | 16325379 |
Hgene | BMP7 | GO:0045669 | positive regulation of osteoblast differentiation | 18436533 |
Hgene | BMP7 | GO:0045786 | negative regulation of cell cycle | 11502704 |
Hgene | BMP7 | GO:0045839 | negative regulation of mitotic nuclear division | 17244894 |
Hgene | BMP7 | GO:0045892 | negative regulation of transcription, DNA-templated | 15100360|17244894 |
Hgene | BMP7 | GO:0045893 | positive regulation of transcription, DNA-templated | 14517293|15100360|16049014 |
Hgene | BMP7 | GO:0048762 | mesenchymal cell differentiation | 9693150 |
Hgene | BMP7 | GO:0048812 | neuron projection morphogenesis | 16325379 |
Hgene | BMP7 | GO:0060393 | regulation of pathway-restricted SMAD protein phosphorylation | 16049014 |
Hgene | BMP7 | GO:0060395 | SMAD protein signal transduction | 17244894 |
Hgene | BMP7 | GO:0060548 | negative regulation of cell death | 12631064 |
Hgene | BMP7 | GO:0070487 | monocyte aggregation | 15100360 |
Hgene | BMP7 | GO:0072125 | negative regulation of glomerular mesangial cell proliferation | 17244894 |
Hgene | BMP7 | GO:1900006 | positive regulation of dendrite development | 11580864 |
Hgene | BMP7 | GO:1900106 | positive regulation of hyaluranon cable assembly | 15100360 |
Tgene | PARP1 | GO:0006471 | protein ADP-ribosylation | 7852410|17396150|26344098|27067600 |
Tgene | PARP1 | GO:0006915 | apoptotic process | 15565177 |
Tgene | PARP1 | GO:0018312 | peptidyl-serine ADP-ribosylation | 28190768 |
Tgene | PARP1 | GO:0018424 | peptidyl-glutamic acid poly-ADP-ribosylation | 19764761 |
Tgene | PARP1 | GO:0030592 | DNA ADP-ribosylation | 27471034 |
Tgene | PARP1 | GO:0032869 | cellular response to insulin stimulus | 19303849 |
Tgene | PARP1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 11112786 |
Tgene | PARP1 | GO:0050790 | regulation of catalytic activity | 25749521 |
Tgene | PARP1 | GO:0070212 | protein poly-ADP-ribosylation | 15674325|19470756|25043379 |
Tgene | PARP1 | GO:0070213 | protein auto-ADP-ribosylation | 19764761 |
Tgene | PARP1 | GO:1905168 | positive regulation of double-strand break repair via homologous recombination | 26344098|30356214 |
Tgene | PARP1 | GO:1990966 | ATP generation from poly-ADP-D-ribose | 27257257 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Fusion Gene ORF analysis for BMP7-PARP1 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for BMP7-PARP1 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for BMP7-PARP1 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:55749986/:226579082) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for BMP7-PARP1 |
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Fusion Gene PPI Analysis for BMP7-PARP1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for BMP7-PARP1 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for BMP7-PARP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | BMP7 | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
Hgene | BMP7 | C0376358 | Malignant neoplasm of prostate | 2 | CTD_human |
Hgene | BMP7 | C0005974 | Bone Resorption | 1 | CTD_human |
Hgene | BMP7 | C0014175 | Endometriosis | 1 | CTD_human |
Hgene | BMP7 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | BMP7 | C0024623 | Malignant neoplasm of stomach | 1 | CTD_human |
Hgene | BMP7 | C0034069 | Pulmonary Fibrosis | 1 | CTD_human |
Hgene | BMP7 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Hgene | BMP7 | C0041696 | Unipolar Depression | 1 | PSYGENET |
Hgene | BMP7 | C0269102 | Endometrioma | 1 | CTD_human |
Hgene | BMP7 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
Hgene | BMP7 | C1708349 | Hereditary Diffuse Gastric Cancer | 1 | CTD_human |
Hgene | BMP7 | C1968949 | Cakut | 1 | GENOMICS_ENGLAND |
Hgene | BMP7 | C4721507 | Alveolitis, Fibrosing | 1 | CTD_human |
Tgene | C0022658 | Kidney Diseases | 2 | CTD_human | |
Tgene | C0002170 | Alopecia | 1 | CTD_human | |
Tgene | C0002871 | Anemia | 1 | CTD_human | |
Tgene | C0004096 | Asthma | 1 | CTD_human | |
Tgene | C0004153 | Atherosclerosis | 1 | CTD_human | |
Tgene | C0006142 | Malignant neoplasm of breast | 1 | CTD_human;UNIPROT | |
Tgene | C0007786 | Brain Ischemia | 1 | CTD_human | |
Tgene | C0009402 | Colorectal Carcinoma | 1 | CTD_human | |
Tgene | C0009404 | Colorectal Neoplasms | 1 | CTD_human | |
Tgene | C0011603 | Dermatitis | 1 | CTD_human | |
Tgene | C0014518 | Toxic Epidermal Necrolysis | 1 | CTD_human | |
Tgene | C0015697 | Arterial Fatty Streak | 1 | CTD_human | |
Tgene | C0019158 | Hepatitis | 1 | CTD_human | |
Tgene | C0020796 | Profound Mental Retardation | 1 | CTD_human | |
Tgene | C0021368 | Inflammation | 1 | CTD_human | |
Tgene | C0022821 | Kyphosis deformity of spine | 1 | CTD_human | |
Tgene | C0025202 | melanoma | 1 | CTD_human | |
Tgene | C0025363 | Mental Retardation, Psychosocial | 1 | CTD_human | |
Tgene | C0026764 | Multiple Myeloma | 1 | CTD_human | |
Tgene | C0028754 | Obesity | 1 | CTD_human | |
Tgene | C0032285 | Pneumonia | 1 | CTD_human | |
Tgene | C0032300 | Lobar Pneumonia | 1 | CTD_human | |
Tgene | C0033141 | Cardiomyopathies, Primary | 1 | CTD_human | |
Tgene | C0033578 | Prostatic Neoplasms | 1 | CTD_human | |
Tgene | C0034069 | Pulmonary Fibrosis | 1 | CTD_human | |
Tgene | C0036529 | Myocardial Diseases, Secondary | 1 | CTD_human | |
Tgene | C0038325 | Stevens-Johnson Syndrome | 1 | CTD_human | |
Tgene | C0042842 | Vitamin A Deficiency | 1 | CTD_human | |
Tgene | C0086873 | Pseudopelade | 1 | CTD_human | |
Tgene | C0162311 | Androgenetic Alopecia | 1 | CTD_human | |
Tgene | C0242422 | Parkinsonian Disorders | 1 | CTD_human | |
Tgene | C0242423 | Ramsay Hunt Paralysis Syndrome | 1 | CTD_human | |
Tgene | C0263477 | Female pattern alopecia (disorder) | 1 | CTD_human | |
Tgene | C0264956 | Atheroma | 1 | CTD_human | |
Tgene | C0345967 | Malignant mesothelioma | 1 | CTD_human | |
Tgene | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human | |
Tgene | C0678222 | Breast Carcinoma | 1 | CTD_human | |
Tgene | C0752097 | Autosomal Dominant Juvenile Parkinson Disease | 1 | CTD_human | |
Tgene | C0752098 | Autosomal Dominant Parkinsonism | 1 | CTD_human | |
Tgene | C0752100 | Autosomal Recessive Parkinsonism | 1 | CTD_human | |
Tgene | C0752101 | Parkinsonism, Experimental | 1 | CTD_human | |
Tgene | C0752104 | Familial Juvenile Parkinsonism | 1 | CTD_human | |
Tgene | C0752105 | Parkinsonism, Juvenile | 1 | CTD_human | |
Tgene | C0878544 | Cardiomyopathies | 1 | CTD_human | |
Tgene | C0887898 | Experimental Lung Inflammation | 1 | CTD_human | |
Tgene | C0917798 | Cerebral Ischemia | 1 | CTD_human | |
Tgene | C0917816 | Mental deficiency | 1 | CTD_human | |
Tgene | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human | |
Tgene | C1274933 | Drug-Induced Stevens Johnson Syndrome | 1 | CTD_human | |
Tgene | C1458155 | Mammary Neoplasms | 1 | CTD_human | |
Tgene | C1563937 | Atherogenesis | 1 | CTD_human | |
Tgene | C1868675 | PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE | 1 | CTD_human | |
Tgene | C2931673 | Ceroid lipofuscinosis, neuronal 1, infantile | 1 | CTD_human | |
Tgene | C2936350 | Plaque, Atherosclerotic | 1 | CTD_human | |
Tgene | C2936351 | Fibroatheroma | 1 | CTD_human | |
Tgene | C3658301 | Mycoplasma-Induced Stevens-Johnson Syndrome | 1 | CTD_human | |
Tgene | C3658302 | Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum | 1 | CTD_human | |
Tgene | C3714636 | Pneumonitis | 1 | CTD_human | |
Tgene | C3714756 | Intellectual Disability | 1 | CTD_human | |
Tgene | C4083212 | Alopecia, Male Pattern | 1 | CTD_human | |
Tgene | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human | |
Tgene | C4721507 | Alveolitis, Fibrosing | 1 | CTD_human |