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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BNIP3L-XPA (FusionGDB2 ID:HG665TG7507)

Fusion Gene Summary for BNIP3L-XPA

check button Fusion gene summary
Fusion gene informationFusion gene name: BNIP3L-XPA
Fusion gene ID: hg665tg7507
HgeneTgene
Gene symbol

BNIP3L

XPA

Gene ID

665

7507

Gene nameBCL2 interacting protein 3 likeXPA, DNA damage recognition and repair factor
SynonymsBNIP3a|NIXXP1|XPAC
Cytomap('BNIP3L')('XPA')

8p21.2

9q22.33

Type of geneprotein-codingprotein-coding
DescriptionBCL2/adenovirus E1B 19 kDa protein-interacting protein 3-likeBCL2/adenovirus E1B 19 kDa protein-interacting protein 3ABCL2/adenovirus E1B 19-kd protein-interacting protein 3aBCL2/adenovirus E1B 19kDa interacting protein 3 likeNIP-3-like protein XNIP3DNA repair protein complementing XP-A cellsxeroderma pigmentosum group A-complementing proteinxeroderma pigmentosum, complementation group A
Modification date2020031320200322
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000521254, ENST00000380629, 
ENST00000518611, ENST00000520409, 
ENST00000523515, 
Fusion gene scores* DoF score7 X 7 X 2=985 X 5 X 2=50
# samples 95
** MAII scorelog2(9/98*10)=-0.122856747785533
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/50*10)=0
Context

PubMed: BNIP3L [Title/Abstract] AND XPA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBNIP3L(26265892)-XPA(100437869), # samples:1
Anticipated loss of major functional domain due to fusion event.BNIP3L-XPA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BNIP3L-XPA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BNIP3L-XPA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BNIP3L-XPA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBNIP3L

GO:0043065

positive regulation of apoptotic process

9973195

HgeneBNIP3L

GO:0043066

negative regulation of apoptotic process

10381623

HgeneBNIP3L

GO:0051607

defense response to virus

9973195

TgeneXPA

GO:0006281

DNA repair

1601884

TgeneXPA

GO:0009650

UV protection

1601884


check buttonFusion gene breakpoints across BNIP3L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across XPA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-BP-4344-01ABNIP3Lchr8

26265892

+XPAchr9

100437869

-


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Fusion Gene ORF analysis for BNIP3L-XPA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000521254ENST00000375128BNIP3Lchr8

26265892

+XPAchr9

100437869

-
3UTR-5UTRENST00000521254ENST00000485042BNIP3Lchr8

26265892

+XPAchr9

100437869

-
5CDS-5UTRENST00000380629ENST00000485042BNIP3Lchr8

26265892

+XPAchr9

100437869

-
5CDS-5UTRENST00000518611ENST00000485042BNIP3Lchr8

26265892

+XPAchr9

100437869

-
5CDS-5UTRENST00000520409ENST00000485042BNIP3Lchr8

26265892

+XPAchr9

100437869

-
5CDS-5UTRENST00000523515ENST00000485042BNIP3Lchr8

26265892

+XPAchr9

100437869

-
In-frameENST00000380629ENST00000375128BNIP3Lchr8

26265892

+XPAchr9

100437869

-
In-frameENST00000518611ENST00000375128BNIP3Lchr8

26265892

+XPAchr9

100437869

-
In-frameENST00000520409ENST00000375128BNIP3Lchr8

26265892

+XPAchr9

100437869

-
In-frameENST00000523515ENST00000375128BNIP3Lchr8

26265892

+XPAchr9

100437869

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000380629BNIP3Lchr826265892+ENST00000375128XPAchr9100437869-152384471904277
ENST00000523515BNIP3Lchr826265892+ENST00000375128XPAchr9100437869-129161219672217
ENST00000520409BNIP3Lchr826265892+ENST00000375128XPAchr9100437869-127259312653213
ENST00000518611BNIP3Lchr826265892+ENST00000375128XPAchr9100437869-1346667176727183

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000380629ENST00000375128BNIP3Lchr826265892+XPAchr9100437869-0.0017586010.9982414
ENST00000523515ENST00000375128BNIP3Lchr826265892+XPAchr9100437869-0.0037722260.99622774
ENST00000520409ENST00000375128BNIP3Lchr826265892+XPAchr9100437869-0.0043205270.99567956
ENST00000518611ENST00000375128BNIP3Lchr826265892+XPAchr9100437869-0.0061523660.99384767

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Fusion Genomic Features for BNIP3L-XPA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for BNIP3L-XPA


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:26265892/chr9:100437869)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBNIP3Lchr8:26265892chr9:100437869ENST00000380629+56126_148203220.0MotifNote=BH3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBNIP3Lchr8:26265892chr9:100437869ENST00000380629+56188_208203220.0TransmembraneHelical
TgeneXPAchr8:26265892chr9:100437869ENST000003751284678_84224274.0Compositional biasNote=Poly-Glu
TgeneXPAchr8:26265892chr9:100437869ENST000003751284626_47224274.0MotifNuclear localization signal
TgeneXPAchr8:26265892chr9:100437869ENST0000037512846105_129224274.0Zinc finger.


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Fusion Gene Sequence for BNIP3L-XPA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>9994_9994_1_BNIP3L-XPA_BNIP3L_chr8_26265892_ENST00000380629_XPA_chr9_100437869_ENST00000375128_length(transcript)=1523nt_BP=844nt
GCGCGTCAGCCTGACTCGAGCGTCTCCACGTCCGGGGCCCGCAGGGGAGCGCCCCTGCCCCGTCCGGTCGCTTGTTGTGTTGTCATCACG
TGGCCTGGGCGGGCCCTGACGTCAGGGGCAGGGGAGGGACGGCGCAGGCGCAGAAAAGGGGGCGGCGGACTCGGCTTGTTGTGTTGCTGC
CTGAGTGCCGGAGACGGTCCTGCTGCTGCCGCAGTCCTGCCAGCTGTCCGACAATGTCGTCCCACCTAGTCGAGCCGCCGCCGCCCCTGC
ACAACAACAACAACAACTGCGAGGAAAATGAGCAGTCTCTGCCCCCGCCGGCCGGCCTCAACAGTTCCTGGGTGGAGCTACCCATGAACA
GCAGCAATGGCAATGATAATGGCAATGGGAAAAATGGGGGGCTGGAACACGTACCATCCTCATCCTCCATCCACAATGGAGACATGGAGA
AGATTCTTTTGGATGCACAACATGAATCAGGACAGAGTAGTTCCAGAGGCAGTTCTCACTGTGACAGCCCTTCGCCACAAGAAGATGGGC
AGATCATGTTTGATGTGGAAATGCACACCAGCAGGGACCATAGCTCTCAGTCAGAAGAAGAAGTTGTAGAAGGAGAGAAGGAAGTCGAGG
CTTTGAAGAAAAGTGCGGACTGGGTATCAGACTGGTCCAGTAGACCCGAAAACATTCCACCCAAGGAGTTCCACTTCAGACACCCTAAAC
GTTCTGTGTCTTTAAGCATGAGGAAAAGTGGAGCCATGAAGAAAGGGGGTATTTTCTCCGCAGAATTTCTGAAGGTGTTCATTCCATCTC
TCTTCCTTTCTCATGTTTTGGCTTTGGGGCTAGGAATTGCGGCGAGCAGTAAGAAGCAGCGTGTGGAAAAGGGAGACGATTGTTCATCAA
CATGAGTATGGACCAGAAGAAAACCTAGAAGATGACATGTACCGTAAGACTTGTACTATGTGTGGCCATGAACTGACATATGAAAAAATG
TGATTTTTTAGTTCAGTGACCTGTTTTATAGAATTTTATATTTAAATAAAGGAAATTTAGATTGGTCCTTTTCAAAATTCAAAAAAAAAA
GCAACATCTTCATAGATGAATGAAACCCTTGTATAAGTAATACTTCAGTAATAATTATGTATGTTATGGCTTAAAAGCAAGTTTCAGTGA
AGGTCACCTGGCCTGGTTGTGTGCACAATGTCATGTCTGTGATTGCCTTCTTACAACAGAGATGGGAGCTGAGTGCTAGAGTAGGTGCAG
AAGTGGTAGGTCAGCTACAAATTTGAGGACAAGATACCAAGGCAAACCCTAGATTGGGGTAGAGGGAAAAGGGTTCAACAAAGGCTGAAC
TGGATTCTTAACCAAGAAACAAATAATAGCAATGGTGGTGCACCACTGTACCCCAGGTTCTAGTCATGTGTTTTTTAGGACGATTTCTGT
CTCCACGATGGTGGAAACAGTGGGGAACTACTGCTGGAAAAAGCCCTAATAGCAGAAATAAACATTGAGTTGTACGAGTCTGA

>9994_9994_1_BNIP3L-XPA_BNIP3L_chr8_26265892_ENST00000380629_XPA_chr9_100437869_ENST00000375128_length(amino acids)=277AA_BP=251
MLCCHHVAWAGPDVRGRGGTAQAQKRGRRTRLVVLLPECRRRSCCCRSPASCPTMSSHLVEPPPPLHNNNNNCEENEQSLPPPAGLNSSW
VELPMNSSNGNDNGNGKNGGLEHVPSSSSIHNGDMEKILLDAQHESGQSSSRGSSHCDSPSPQEDGQIMFDVEMHTSRDHSSQSEEEVVE
GEKEVEALKKSADWVSDWSSRPENIPPKEFHFRHPKRSVSLSMRKSGAMKKGGIFSAEFLKVFIPSLFLSHVLALGLGIAASSKKQRVEK
GDDCSST

--------------------------------------------------------------
>9994_9994_2_BNIP3L-XPA_BNIP3L_chr8_26265892_ENST00000518611_XPA_chr9_100437869_ENST00000375128_length(transcript)=1346nt_BP=667nt
GTGGCTCCACCCCTTCAACTTTTTGTCCAAGAAAACTTTTCGTGTTTGCCTGTAGCTGATGTGCAGTTGTTTCTGCTCCCAAATCAACAG
GGTTTAATGAAAACCCTAGAAAGTAGAAACCCGTGGGAGAGAAAAGAAAAAAGACAAGTTCACAAGGTTCCTGGGTGGAGCTACCCATGA
ACAGCAGCAATGGCAATGATAATGGCAATGGGAAAAATGGGGGGCTGGAACACGTACCATCCTCATCCTCCATCCACAATGGAGACATGG
AGAAGATTCTTTTGGATGCACAACATGAATCAGGACAGAGTAGTTCCAGAGGCAGTTCTCACTGTGACAGCCCTTCGCCACAAGAAGATG
GGCAGATCATGTTTGATGTGGAAATGCACACCAGCAGGGACCATAGCTCTCAGTCAGAAGAAGAAGTTGTAGAAGGAGAGAAGGAAGTCG
AGGCTTTGAAGAAAAGTGCGGACTGGGTATCAGACTGGTCCAGTAGACCCGAAAACATTCCACCCAAGGAGTTCCACTTCAGACACCCTA
AACGTTCTGTGTCTTTAAGCATGAGGAAAAGTGGAGCCATGAAGAAAGGGGGTATTTTCTCCGCAGAATTTCTGAAGGTGTTCATTCCAT
CTCTCTTCCTTTCTCATGTTTTGGCTTTGGGGCTAGGAATTGCGGCGAGCAGTAAGAAGCAGCGTGTGGAAAAGGGAGACGATTGTTCAT
CAACATGAGTATGGACCAGAAGAAAACCTAGAAGATGACATGTACCGTAAGACTTGTACTATGTGTGGCCATGAACTGACATATGAAAAA
ATGTGATTTTTTAGTTCAGTGACCTGTTTTATAGAATTTTATATTTAAATAAAGGAAATTTAGATTGGTCCTTTTCAAAATTCAAAAAAA
AAAGCAACATCTTCATAGATGAATGAAACCCTTGTATAAGTAATACTTCAGTAATAATTATGTATGTTATGGCTTAAAAGCAAGTTTCAG
TGAAGGTCACCTGGCCTGGTTGTGTGCACAATGTCATGTCTGTGATTGCCTTCTTACAACAGAGATGGGAGCTGAGTGCTAGAGTAGGTG
CAGAAGTGGTAGGTCAGCTACAAATTTGAGGACAAGATACCAAGGCAAACCCTAGATTGGGGTAGAGGGAAAAGGGTTCAACAAAGGCTG
AACTGGATTCTTAACCAAGAAACAAATAATAGCAATGGTGGTGCACCACTGTACCCCAGGTTCTAGTCATGTGTTTTTTAGGACGATTTC
TGTCTCCACGATGGTGGAAACAGTGGGGAACTACTGCTGGAAAAAGCCCTAATAGCAGAAATAAACATTGAGTTGTACGAGTCTGA

>9994_9994_2_BNIP3L-XPA_BNIP3L_chr8_26265892_ENST00000518611_XPA_chr9_100437869_ENST00000375128_length(amino acids)=183AA_BP=157
MNSSNGNDNGNGKNGGLEHVPSSSSIHNGDMEKILLDAQHESGQSSSRGSSHCDSPSPQEDGQIMFDVEMHTSRDHSSQSEEEVVEGEKE
VEALKKSADWVSDWSSRPENIPPKEFHFRHPKRSVSLSMRKSGAMKKGGIFSAEFLKVFIPSLFLSHVLALGLGIAASSKKQRVEKGDDC
SST

--------------------------------------------------------------
>9994_9994_3_BNIP3L-XPA_BNIP3L_chr8_26265892_ENST00000520409_XPA_chr9_100437869_ENST00000375128_length(transcript)=1272nt_BP=593nt
CTCTGTTGCCTCCTGGGGTCTTGGGCCCGGGGCCGTTTGGGCTCGCGGTCCGGGAGCGGCGCGGGTAGCGCGGATCCCCCTGGTTCCTGG
GTGGAGCTACCCATGAACAGCAGCAATGGCAATGATAATGGCAATGGGAAAAATGGGGGGCTGGAACACGTACCATCCTCATCCTCCATC
CACAATGGAGACATGGAGAAGATTCTTTTGGATGCACAACATGAATCAGGACAGAGTAGTTCCAGAGGCAGTTCTCACTGTGACAGCCCT
TCGCCACAAGAAGATGGGCAGATCATGTTTGATGTGGAAATGCACACCAGCAGGGACCATAGCTCTCAGTCAGAAGAAGAAGTTGTAGAA
GGAGAGAAGGAAGTCGAGGCTTTGAAGAAAAGTGCGGACTGGGTATCAGACTGGTCCAGTAGACCCGAAAACATTCCACCCAAGGAGTTC
CACTTCAGACACCCTAAACGTTCTGTGTCTTTAAGCATGAGGAAAAGTGGAGCCATGAAGAAAGGGGGTATTTTCTCCGCAGAATTTCTG
AAGGTGTTCATTCCATCTCTCTTCCTTTCTCATGTTTTGGCTTTGGGGCTAGGAATTGCGGCGAGCAGTAAGAAGCAGCGTGTGGAAAAG
GGAGACGATTGTTCATCAACATGAGTATGGACCAGAAGAAAACCTAGAAGATGACATGTACCGTAAGACTTGTACTATGTGTGGCCATGA
ACTGACATATGAAAAAATGTGATTTTTTAGTTCAGTGACCTGTTTTATAGAATTTTATATTTAAATAAAGGAAATTTAGATTGGTCCTTT
TCAAAATTCAAAAAAAAAAGCAACATCTTCATAGATGAATGAAACCCTTGTATAAGTAATACTTCAGTAATAATTATGTATGTTATGGCT
TAAAAGCAAGTTTCAGTGAAGGTCACCTGGCCTGGTTGTGTGCACAATGTCATGTCTGTGATTGCCTTCTTACAACAGAGATGGGAGCTG
AGTGCTAGAGTAGGTGCAGAAGTGGTAGGTCAGCTACAAATTTGAGGACAAGATACCAAGGCAAACCCTAGATTGGGGTAGAGGGAAAAG
GGTTCAACAAAGGCTGAACTGGATTCTTAACCAAGAAACAAATAATAGCAATGGTGGTGCACCACTGTACCCCAGGTTCTAGTCATGTGT
TTTTTAGGACGATTTCTGTCTCCACGATGGTGGAAACAGTGGGGAACTACTGCTGGAAAAAGCCCTAATAGCAGAAATAAACATTGAGTT
GTACGAGTCTGA

>9994_9994_3_BNIP3L-XPA_BNIP3L_chr8_26265892_ENST00000520409_XPA_chr9_100437869_ENST00000375128_length(amino acids)=213AA_BP=187
MGSWARGRLGSRSGSGAGSADPPGSWVELPMNSSNGNDNGNGKNGGLEHVPSSSSIHNGDMEKILLDAQHESGQSSSRGSSHCDSPSPQE
DGQIMFDVEMHTSRDHSSQSEEEVVEGEKEVEALKKSADWVSDWSSRPENIPPKEFHFRHPKRSVSLSMRKSGAMKKGGIFSAEFLKVFI
PSLFLSHVLALGLGIAASSKKQRVEKGDDCSST

--------------------------------------------------------------
>9994_9994_4_BNIP3L-XPA_BNIP3L_chr8_26265892_ENST00000523515_XPA_chr9_100437869_ENST00000375128_length(transcript)=1291nt_BP=612nt
CTGTCAAGAGGAGGGGCGCCTGCCTTGCTCCGGGCCTCTCTGTTGCCTCCTGGGGTCTTGGGCCCGGGGCCGTTTGGGCTCGCGGTCCGG
GAGCGGCGCGGGTTCCTGGGTGGAGCTACCCATGAACAGCAGCAATGGCAATGATAATGGCAATGGGAAAAATGGGGGGCTGGAACACGT
ACCATCCTCATCCTCCATCCACAATGGAGACATGGAGAAGATTCTTTTGGATGCACAACATGAATCAGGACAGAGTAGTTCCAGAGGCAG
TTCTCACTGTGACAGCCCTTCGCCACAAGAAGATGGGCAGATCATGTTTGATGTGGAAATGCACACCAGCAGGGACCATAGCTCTCAGTC
AGAAGAAGAAGTTGTAGAAGGAGAGAAGGAAGTCGAGGCTTTGAAGAAAAGTGCGGACTGGGTATCAGACTGGTCCAGTAGACCCGAAAA
CATTCCACCCAAGGAGTTCCACTTCAGACACCCTAAACGTTCTGTGTCTTTAAGCATGAGGAAAAGTGGAGCCATGAAGAAAGGGGGTAT
TTTCTCCGCAGAATTTCTGAAGGTGTTCATTCCATCTCTCTTCCTTTCTCATGTTTTGGCTTTGGGGCTAGGAATTGCGGCGAGCAGTAA
GAAGCAGCGTGTGGAAAAGGGAGACGATTGTTCATCAACATGAGTATGGACCAGAAGAAAACCTAGAAGATGACATGTACCGTAAGACTT
GTACTATGTGTGGCCATGAACTGACATATGAAAAAATGTGATTTTTTAGTTCAGTGACCTGTTTTATAGAATTTTATATTTAAATAAAGG
AAATTTAGATTGGTCCTTTTCAAAATTCAAAAAAAAAAGCAACATCTTCATAGATGAATGAAACCCTTGTATAAGTAATACTTCAGTAAT
AATTATGTATGTTATGGCTTAAAAGCAAGTTTCAGTGAAGGTCACCTGGCCTGGTTGTGTGCACAATGTCATGTCTGTGATTGCCTTCTT
ACAACAGAGATGGGAGCTGAGTGCTAGAGTAGGTGCAGAAGTGGTAGGTCAGCTACAAATTTGAGGACAAGATACCAAGGCAAACCCTAG
ATTGGGGTAGAGGGAAAAGGGTTCAACAAAGGCTGAACTGGATTCTTAACCAAGAAACAAATAATAGCAATGGTGGTGCACCACTGTACC
CCAGGTTCTAGTCATGTGTTTTTTAGGACGATTTCTGTCTCCACGATGGTGGAAACAGTGGGGAACTACTGCTGGAAAAAGCCCTAATAG
CAGAAATAAACATTGAGTTGTACGAGTCTGA

>9994_9994_4_BNIP3L-XPA_BNIP3L_chr8_26265892_ENST00000523515_XPA_chr9_100437869_ENST00000375128_length(amino acids)=217AA_BP=191
MPCSGPLCCLLGSWARGRLGSRSGSGAGSWVELPMNSSNGNDNGNGKNGGLEHVPSSSSIHNGDMEKILLDAQHESGQSSSRGSSHCDSP
SPQEDGQIMFDVEMHTSRDHSSQSEEEVVEGEKEVEALKKSADWVSDWSSRPENIPPKEFHFRHPKRSVSLSMRKSGAMKKGGIFSAEFL
KVFIPSLFLSHVLALGLGIAASSKKQRVEKGDDCSST

--------------------------------------------------------------

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Fusion Gene PPI Analysis for BNIP3L-XPA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneXPAchr8:26265892chr9:100437869ENST00000375128464_97224.33333333333334274.0CEP164 and required for UV resistance


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BNIP3L-XPA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BNIP3L-XPA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0268135Xeroderma pigmentosum, group A17CLINGEN;GENOMICS_ENGLAND;UNIPROT
TgeneC0007114Malignant neoplasm of skin2CTD_human
TgeneC0037286Skin Neoplasms2CTD_human
TgeneC1449861Micronuclei, Chromosome-Defective2CTD_human
TgeneC1449862Micronuclei, Genotoxicant-Induced2CTD_human
TgeneC0021841Intestinal Neoplasms1CTD_human
TgeneC0023903Liver neoplasms1CTD_human
TgeneC0043346Xeroderma Pigmentosum1CTD_human
TgeneC0345904Malignant neoplasm of liver1CTD_human
TgeneC0346627Intestinal Cancer1CTD_human
TgeneC1368275Pigmented Basal Cell Carcinoma1CTD_human
TgeneC3714756Intellectual Disability1GENOMICS_ENGLAND
TgeneC4721806Carcinoma, Basal Cell1CTD_human