Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:TROVE2-CDC73 (FusionGDB2 ID:HG6738TG79577)

Fusion Gene Summary for TROVE2-CDC73

check button Fusion gene summary
Fusion gene informationFusion gene name: TROVE2-CDC73
Fusion gene ID: hg6738tg79577
HgeneTgene
Gene symbol

TROVE2

CDC73

Gene ID

6738

79577

Gene nameRo60, Y RNA binding proteincell division cycle 73
SynonymsRORNP|SSA2|TROVE2C1orf28|FIHP|HPTJT|HRPT1|HRPT2|HYX
Cytomap('TROVE2')('CDC73')

1q31.2

1q31.2

Type of geneprotein-codingprotein-coding
Description60 kDa SS-A/Ro ribonucleoprotein60 kDa ribonucleoprotein RoRo/SSA 60kDaSjogren syndrome antigen A2 (60kD, ribonucleoprotein autoantigen SS-A/Ro)TROVE domain family member 2gastric cancer multi-drug resistance proteinro60 autoantigensjoegren syndromparafibrominFamilial isolated hyperparathyroidismPaf1/RNA polymerase II complex componentcell division cycle 73 Paf1/RNA polymerase II complex component-like proteincell division cycle 73, Paf1/RNA polymerase II complex component, homologcell divisio
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000460715, ENST00000367441, 
ENST00000367443, ENST00000367444, 
ENST00000367445, ENST00000367446, 
ENST00000400968, ENST00000416058, 
ENST00000432079, 		ENST00000367443, 
ENST00000367441, ENST00000367444, 
ENST00000367445, ENST00000367446, 
ENST00000400968, ENST00000416058, 
ENST00000432079, ENST00000460715, 
Fusion gene scores* DoF score2 X 3 X 2=127 X 7 X 4=196
# samples 27
** MAII scorelog2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TROVE2 [Title/Abstract] AND CDC73 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTROVE2(193053785)-CDC73(193218858), # samples:1
TROVE2(193053787)-CDC73(193218860), # samples:1
Anticipated loss of major functional domain due to fusion event.TROVE2-CDC73 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TROVE2-CDC73 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TROVE2-CDC73 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TROVE2-CDC73 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TROVE2-CDC73 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
TROVE2-CDC73 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
TROVE2-CDC73 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
TROVE2-CDC73 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTROVE2

GO:0010468

regulation of gene expression

26382853

HgeneTROVE2

GO:0035457

cellular response to interferon-alpha

26382853

TgeneCDC73

GO:0008285

negative regulation of cell proliferation

16989776

TgeneCDC73

GO:0010390

histone monoubiquitination

16307923

TgeneCDC73

GO:0030177

positive regulation of Wnt signaling pathway

16630820

TgeneCDC73

GO:0032968

positive regulation of transcription elongation from RNA polymerase II promoter

20178742

TgeneCDC73

GO:0033523

histone H2B ubiquitination

16307923

TgeneCDC73

GO:0045638

negative regulation of myeloid cell differentiation

20541477

TgeneCDC73

GO:0045944

positive regulation of transcription by RNA polymerase II

20178742

TgeneCDC73

GO:2000134

negative regulation of G1/S transition of mitotic cell cycle

16989776


check buttonFusion gene breakpoints across TROVE2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CDC73 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-D9-A4Z3-01ATROVE2chr1

193053785

+CDC73chr1

193218858

+
ChimerDB4SKCMTCGA-D9-A4Z3-01ATROVE2chr1

193053787

+CDC73chr1

193218860

+


Top

Fusion Gene ORF analysis for TROVE2-CDC73

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000460715ENST00000367435TROVE2chr1

193053785

+CDC73chr1

193218858

+
3UTR-3CDSENST00000460715ENST00000367435TROVE2chr1

193053787

+CDC73chr1

193218860

+
3UTR-3UTRENST00000460715ENST00000477868TROVE2chr1

193053785

+CDC73chr1

193218858

+
3UTR-3UTRENST00000460715ENST00000477868TROVE2chr1

193053787

+CDC73chr1

193218860

+
5CDS-3UTRENST00000367441ENST00000477868TROVE2chr1

193053785

+CDC73chr1

193218858

+
5CDS-3UTRENST00000367441ENST00000477868TROVE2chr1

193053787

+CDC73chr1

193218860

+
5CDS-3UTRENST00000367443ENST00000477868TROVE2chr1

193053785

+CDC73chr1

193218858

+
5CDS-3UTRENST00000367443ENST00000477868TROVE2chr1

193053787

+CDC73chr1

193218860

+
5CDS-3UTRENST00000367444ENST00000477868TROVE2chr1

193053785

+CDC73chr1

193218858

+
5CDS-3UTRENST00000367444ENST00000477868TROVE2chr1

193053787

+CDC73chr1

193218860

+
5CDS-3UTRENST00000367445ENST00000477868TROVE2chr1

193053785

+CDC73chr1

193218858

+
5CDS-3UTRENST00000367445ENST00000477868TROVE2chr1

193053787

+CDC73chr1

193218860

+
5CDS-3UTRENST00000367446ENST00000477868TROVE2chr1

193053785

+CDC73chr1

193218858

+
5CDS-3UTRENST00000367446ENST00000477868TROVE2chr1

193053787

+CDC73chr1

193218860

+
5CDS-3UTRENST00000400968ENST00000477868TROVE2chr1

193053785

+CDC73chr1

193218858

+
5CDS-3UTRENST00000400968ENST00000477868TROVE2chr1

193053787

+CDC73chr1

193218860

+
5CDS-3UTRENST00000416058ENST00000477868TROVE2chr1

193053785

+CDC73chr1

193218858

+
5CDS-3UTRENST00000416058ENST00000477868TROVE2chr1

193053787

+CDC73chr1

193218860

+
5CDS-3UTRENST00000432079ENST00000477868TROVE2chr1

193053785

+CDC73chr1

193218858

+
5CDS-3UTRENST00000432079ENST00000477868TROVE2chr1

193053787

+CDC73chr1

193218860

+
Frame-shiftENST00000367441ENST00000367435TROVE2chr1

193053785

+CDC73chr1

193218858

+
Frame-shiftENST00000367441ENST00000367435TROVE2chr1

193053787

+CDC73chr1

193218860

+
Frame-shiftENST00000367445ENST00000367435TROVE2chr1

193053785

+CDC73chr1

193218858

+
Frame-shiftENST00000367445ENST00000367435TROVE2chr1

193053787

+CDC73chr1

193218860

+
Frame-shiftENST00000367446ENST00000367435TROVE2chr1

193053785

+CDC73chr1

193218858

+
Frame-shiftENST00000367446ENST00000367435TROVE2chr1

193053787

+CDC73chr1

193218860

+
Frame-shiftENST00000400968ENST00000367435TROVE2chr1

193053785

+CDC73chr1

193218858

+
Frame-shiftENST00000400968ENST00000367435TROVE2chr1

193053787

+CDC73chr1

193218860

+
Frame-shiftENST00000416058ENST00000367435TROVE2chr1

193053785

+CDC73chr1

193218858

+
Frame-shiftENST00000416058ENST00000367435TROVE2chr1

193053787

+CDC73chr1

193218860

+
Frame-shiftENST00000432079ENST00000367435TROVE2chr1

193053785

+CDC73chr1

193218858

+
Frame-shiftENST00000432079ENST00000367435TROVE2chr1

193053787

+CDC73chr1

193218860

+
In-frameENST00000367443ENST00000367435TROVE2chr1

193053785

+CDC73chr1

193218858

+
In-frameENST00000367443ENST00000367435TROVE2chr1

193053787

+CDC73chr1

193218860

+
In-frameENST00000367444ENST00000367435TROVE2chr1

193053785

+CDC73chr1

193218858

+
In-frameENST00000367444ENST00000367435TROVE2chr1

193053787

+CDC73chr1

193218860

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000367444TROVE2chr1193053785+ENST00000367435CDC73chr1193218858+509817301871908573
ENST00000367443TROVE2chr1193053785+ENST00000367435CDC73chr1193218858+509817301871908573
ENST00000367444TROVE2chr1193053787+ENST00000367435CDC73chr1193218860+509817301871908573
ENST00000367443TROVE2chr1193053787+ENST00000367435CDC73chr1193218860+509817301871908573

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000367444ENST00000367435TROVE2chr1193053785+CDC73chr1193218858+0.0001801680.9998198
ENST00000367443ENST00000367435TROVE2chr1193053785+CDC73chr1193218858+0.0001801680.9998198
ENST00000367444ENST00000367435TROVE2chr1193053787+CDC73chr1193218860+0.0001801680.9998198
ENST00000367443ENST00000367435TROVE2chr1193053787+CDC73chr1193218860+0.0001801680.9998198

Top

Fusion Genomic Features for TROVE2-CDC73


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TROVE2chr1193053787+CDC73chr1193218859+0.031974410.9680256
TROVE2chr1193053787+CDC73chr1193218859+0.031974410.9680256

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for TROVE2-CDC73


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:193053785/chr1:193218858)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTROVE2chr1:193053785chr1:193218858ENST00000367443+91116_369514506.0DomainTROVE
HgeneTROVE2chr1:193053787chr1:193218860ENST00000367443+91116_369514506.0DomainTROVE
HgeneTROVE2chr1:193053785chr1:193218858ENST00000367443+911120_284514506.0RegionRNA-binding
HgeneTROVE2chr1:193053785chr1:193218858ENST00000367443+911361_538514506.0RegionVWFA-like domain
HgeneTROVE2chr1:193053787chr1:193218860ENST00000367443+911120_284514506.0RegionRNA-binding
HgeneTROVE2chr1:193053787chr1:193218860ENST00000367443+911361_538514506.0RegionVWFA-like domain

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTROVE2chr1:193053785chr1:193218858ENST00000367441+1816_3690539.0DomainTROVE
HgeneTROVE2chr1:193053785chr1:193218858ENST00000367445+11016_3690535.0DomainTROVE
HgeneTROVE2chr1:193053785chr1:193218858ENST00000367446+1916_3690539.0DomainTROVE
HgeneTROVE2chr1:193053785chr1:193218858ENST00000400968+1916_3690539.0DomainTROVE
HgeneTROVE2chr1:193053787chr1:193218860ENST00000367441+1816_3690539.0DomainTROVE
HgeneTROVE2chr1:193053787chr1:193218860ENST00000367445+11016_3690535.0DomainTROVE
HgeneTROVE2chr1:193053787chr1:193218860ENST00000367446+1916_3690539.0DomainTROVE
HgeneTROVE2chr1:193053787chr1:193218860ENST00000400968+1916_3690539.0DomainTROVE
HgeneTROVE2chr1:193053785chr1:193218858ENST00000367441+18120_2840539.0RegionRNA-binding
HgeneTROVE2chr1:193053785chr1:193218858ENST00000367441+18361_5380539.0RegionVWFA-like domain
HgeneTROVE2chr1:193053785chr1:193218858ENST00000367445+110120_2840535.0RegionRNA-binding
HgeneTROVE2chr1:193053785chr1:193218858ENST00000367445+110361_5380535.0RegionVWFA-like domain
HgeneTROVE2chr1:193053785chr1:193218858ENST00000367446+19120_2840539.0RegionRNA-binding
HgeneTROVE2chr1:193053785chr1:193218858ENST00000367446+19361_5380539.0RegionVWFA-like domain
HgeneTROVE2chr1:193053785chr1:193218858ENST00000400968+19120_2840539.0RegionRNA-binding
HgeneTROVE2chr1:193053785chr1:193218858ENST00000400968+19361_5380539.0RegionVWFA-like domain
HgeneTROVE2chr1:193053787chr1:193218860ENST00000367441+18120_2840539.0RegionRNA-binding
HgeneTROVE2chr1:193053787chr1:193218860ENST00000367441+18361_5380539.0RegionVWFA-like domain
HgeneTROVE2chr1:193053787chr1:193218860ENST00000367445+110120_2840535.0RegionRNA-binding
HgeneTROVE2chr1:193053787chr1:193218860ENST00000367445+110361_5380535.0RegionVWFA-like domain
HgeneTROVE2chr1:193053787chr1:193218860ENST00000367446+19120_2840539.0RegionRNA-binding
HgeneTROVE2chr1:193053787chr1:193218860ENST00000367446+19361_5380539.0RegionVWFA-like domain
HgeneTROVE2chr1:193053787chr1:193218860ENST00000400968+19120_2840539.0RegionRNA-binding
HgeneTROVE2chr1:193053787chr1:193218860ENST00000400968+19361_5380539.0RegionVWFA-like domain
TgeneCDC73chr1:193053785chr1:193218858ENST000003674351417361_364472532.0Compositional biasNote=Poly-Ile
TgeneCDC73chr1:193053787chr1:193218860ENST000003674351417361_364472532.0Compositional biasNote=Poly-Ile
TgeneCDC73chr1:193053785chr1:193218858ENST000003674351417125_139472532.0MotifNote=Nuclear localization signal
TgeneCDC73chr1:193053787chr1:193218860ENST000003674351417125_139472532.0MotifNote=Nuclear localization signal


Top

Fusion Gene Sequence for TROVE2-CDC73


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>94333_94333_1_TROVE2-CDC73_TROVE2_chr1_193053785_ENST00000367443_CDC73_chr1_193218858_ENST00000367435_length(transcript)=5098nt_BP=1730nt
CACAGGCCGACGTCGAGAGGGCCTGCTTTACTCCTCCTCTTTCTCCTCCTTCTCCCGCGGCTTCTGCGCGGAGAGGCGTCGCCCGGGATC
TGGGTTTTGGAAGAAGGATCTTTGTGGGAAGACAGGGTGAATTTATCACAGAGGAATAACGAGGGAGAGGAGAAAGGTTTCCTAAAGACA
AAAAAAAATGGAGGAATCTGTAAACCAAATGCAGCCACTGAATGAGAAGCAGATAGCCAATTCTCAGGATGGATATGTATGGCAAGTCAC
TGACATGAATCGACTACACCGGTTCTTATGTTTCGGTTCTGAAGGTGGGACTTATTATATCAAAGAACAGAAGTTGGGCCTTGAAAATGC
TGAAGCTTTAATTAGATTGATTGAAGATGGCAGAGGATGTGAAGTGATACAAGAAATAAAGTCATTTAGTCAAGAAGGCAGAACCACAAA
GCAAGAGCCTATGCTCTTTGCACTTGCCATTTGTTCCCAGTGCTCCGACATAAGCACAAAACAAGCAGCATTTAAAGCTGTTTCTGAAGT
TTGTCGCATTCCTACCCATCTCTTTACTTTTATCCAGTTTAAGAAAGATCTGAAGGAAAGCATGAAATGTGGCATGTGGGGTCGTGCCCT
CCGGAAGGCTATAGCGGACTGGTACAATGAGAAAGGTGGCATGGCCCTTGCTCTGGCAGTTACAAAATATAAACAGAGAAATGGCTGGTC
TCACAAAGATCTATTAAGATTGTCACATCTTAAACCTTCCAGTGAAGGACTTGCAATTGTGACCAAATATATTACAAAGGGCTGGAAAGA
AGTTCATGAATTGTATAAAGAAAAAGCACTCTCTGTGGAGACTGAAAAATTATTAAAGTATCTGGAGGCTGTAGAGAAAGTGAAGCGCAC
AAGAGATGAGCTAGAAGTCATTCATCTAATAGAAGAACATAGATTAGTTAGAGAACATCTTTTAACAAATCACTTAAAGTCTAAAGAGGT
ATGGAAGGCTTTGTTACAAGAAATGCCGCTTACTGCATTACTAAGGAATCTAGGAAAGATGACTGCTAATTCAGTACTTGAACCAGGAAA
TTCAGAAGTATCTTTAGTATGTGAAAAACTGTGTAATGAAAAACTATTAAAAAAGGCTCGTATACATCCATTTCATATTTTGATCGCATT
AGAAACTTACAAGACAGGTCATGGTCTCAGAGGGAAACTGAAGTGGCGCCCTGATGAAGAAATTTTGAAAGCATTGGATGCTGCTTTTTA
TAAAACATTTAAGACAGTTGAACCAACTGGAAAACGTTTCTTACTAGCTGTTGATGTCAGTGCTTCTATGAACCAAAGAGTTTTGGGTAG
TATACTCAACGCTAGTACAGTTGCTGCAGCAATGTGCATGGTTGTCACACGAACAGAAAAAGATTCTTATGTAGTTGCTTTTTCCGATGA
AATGGTACCATGTCCAGTGACTACAGATATGACCTTACAACAGGTTTTAATGGCTATGAGTCAGATCCCAGCAGGTGGAACTGATTGCTC
TCTTCCAATGATCTGGGCTCAGAAGACAAACACACCTGCTGATGTCTTCATTGTATTCACTGATAATGAGACCTTTGCTGGAGGTGTCCA
TCCTGCTATTGCTCTGAGGGAGTATCGAAAGAAAATGGATATTCCAGCTAAATTGATTGTTTGTGGAATGACATCAAATGGTTTCACCAT
TGCAGACCCAGATGATAGAGTTAAAGCCTTCCATCTGAAGTATGATGAAGTTCGTCTGGATCCAAATGTTCAGAAATGGGATGTAACAGT
ATTAGAACTCAGCTATCACAAACGTCATTTGGATAGACCAGTGTTCTTACGGTTTTGGGAAACATTGGACAGGTACATGGTAAAGCATAA
ATCGCACTTGAGATTCTGAATTATTTGGCTCCTCCATTTCTGGAAATTGAGACTCAAGCTTTATGAATTTATCAAGAACTTAAAAATGAA
GAAGGTCACAGATTGATCTTTTATAAGACCTTATTTGATGCTTTGTGCTTCAAGGAGATGATACCTGTCATCCATATAAGCAAACTTTTT
GGCTTACAACTATTTTTTTAATATTAGCCTTCTAGTCTGTAATGGAAATTGTATATTTTGATAGAAGTTTTTTCTCCATTGGTTAAATTA
GCATTACTTAAAATTTGTTTCTTTAGAAAATAAATGCAGGTTATAAATGTGTGTATATTTAGAGATTATAAGGCTCTCTGAGCCATCTTC
TGATTTTTCATTGCTCTATAATTCTTTTTACTGAAAATACTATGTTATGAATGGTATTAAATTTTAGTCTCTGGAACATCCAAAACCAAG
CAAAGGGATGTGACTATTTTGAATGAATCAGAATGTCAACTTGTATGTACACTATATCTACACTTACTCATTATTTAAAAAGAATAATGA
AAAATCTAGATCAATTCTTCAATTTGATTGAACTGTTCAGCCTTTTCAAGATTTCTTTATTTACAAATGATTACATTTAAATGAATGTAC
ATTCTTCTCACTGACTTTGGTGATTTTGAAACCTAGAATGATGTGTTTCTATCTGTAATATCTTTCCATTTGAAAAAAATCTCAAAACAC
AGATTAAAACCACAATAGGCTGTAGTATTTTTTATTTTGGGAGCCAGAGTATGATTTGGGGGAAGAATATGTATCAGCCCTATTGCAGTA
TAACTTTAAGCTCCTTTTCTCTTTAGTCCACTTTTGATTGTAATTTTTATGGTATAGGATTTTGAATCTTCTATTTTAGGCTTGTCAGTC
TTGGAGTTCTTATCTTCCATTATCCCTAAATATTGATAAACTCCCAGGCACCAAAGAAAACATTTGCTTAATTGTCTGAAAAGAAACAAG
AGAAAAACACTGGTATTTTTATGTCTGTATTCAATATGGTATAAAATATAAAAACTATATTTTAACTTAGTGAAATATTTTACTATTTCT
CTACTTCAGACAAAATGTTGCATCCAAGGTACATCAAGTGACCATTTGCCTTGAACCTTGATTTCACTTTGTTTTTTTTTTTTCCTTAAA
GGCAACTAGGAAGCTTTACTTTCCTAAAGTGTTTTTGCCATTGGAATTTTTGCTGATCACAGTCTTATGTCATTTTTTTCTCTGTTTTTA
TTCCCAGCAATTTTCTCCTAGGTTAACATATTTTTGGTGAACGTTTAGGCCTTTCATAGGTATTAAGCTGACATTATCTAGCTTCTTAAT
GAAATTTAACACTGTCACAAAAATGAGAAGTTATTATTTTTTAAGTGATCACATAGTTCATACCACTAGTAACTAGAAAAGATATTTATT
CACATGATATTTACAAGGCTCTTCAGAAGGGAACAGTCAGCATTTTAAATTACTAGATTTTAGCATACTTAACAAGGTTTGAACAGATTC
TACCCCTATTTTCCTCCCTTTTTAGCGTCTTCTTTCCTTAAAGATAAAAGAAAACTCAAATTTGTTTACATTAGGCTTTCTTAGCATATA
AATATATTTCCAAAATAAATTACATGTTGTGTAAACTTTCTCCATGATGAAATAGTCAAGGACCAGAATCTGTAATATTTTTATGTAAGA
TTACTTGTCAAGACTACTACAAGTCAGTATGAACTACCTTCCCATAAAGATTTTTGGTATTTGTACTTATTTATGAACTTTACTTGAGAC
AGAATATGGTTAAAATTAGGAACATCTACTTTGAATGAGGTTTATTTTTCTATTTTGAATTTGCCTTATGTATATTCAAAGGCTTATGGA
AATACTGTAAAGGAACATTAGGAAAAGGACAAATAGGCTATAACCATCTATCTTAAAATCAGACCCTTAGTATAAGCACCTCTTTTTCTT
TTCCTCTTTGACAATTTAGTCTCTTATTTAGGTCCATGTAATTAATTTCATTCCATTATTTTTTAGCTGTTTATTCTAAAAAACAAAAAT
TTTCAGCCACTCCCATTTATTCTCCCATGACATGGTCCTATATAGCAGTACTTAACACAGTGCCTTGCACATAGTAGGCATTCAGTAAAT
ACTTACATGCATGAATGAATAATGTATTTTCAGTGTAACAAATTTATTATAAAAGTGTAGTTCGACTCTTCTTGGTCTTGGAGTTTGAGA
GTACAGAATTACAGGGAATGAAGAGAGGTATAAGTAGATATTTTAATGGAAATGAAGTATAAATTAATAACTTGACTTACCCCTCCATAA
GTTACTGCTAACTGGAGATACCCTTGTATGCCCAACCTGTAAAGGAAAAAGTTCTATTTCTATATTTATAGGACATTCTTCTCAGTCAAG
GAACAGTAAGAAATATGTAGGTTTCAATCAGTTGCTCTCAACCCTGACTGCATTTTAGAATCATTTGGAGAGTTTTTAAAAATATCCATG
CCTGAATCTTGATTCCCATTTTCATGTAATTTGAGACAAGACCTGGTCATCAGTATTTTTTTTAAAGTTCTCCAGGTAATTTGAATGTGC
AGGAAGGATTCAGAATCACTGGTTTAATTTGTTATTGAAAACAGTACCAGTATTAAATGTGTTTCCTCTTCCTTCTTTTCTGTATGTATG
TGTGGTTTTTGATTTTTTGTTGTTGTTGTTGTTTTGTGGCCACCCTTTGCACTAGACCATCCCTTTTATTGGTGGTATTGGCCTATATTC
CCATTGACAAATGCAATTTTTAATTATTTATTTAATATAGGAGTATTTTACTGTTTAATATTTAAACAATGTTTAATGTATTTCATTATT
AACTAGTATTATAGTTTGTTTTTTTCCCATGTCTCCATAACTTTTACTAACATTTGTTTTTAGCAGCACAACAGTAATCCATATAAAAAC
AACTAATTCATAATGAGGAAAATCTCATAATTTTTAAGGCAGAAAGAAGTATTAATTTTTGATCTGCCATGTAGAATGAGACAAATACAG
TTTGCTTATGAAAGGAAAGTGGCATACTTTTAAATTGGTCTACACAGAAAAGTAAAAGTAAACTATTCATTTAAATAAGATTCATTATCT

>94333_94333_1_TROVE2-CDC73_TROVE2_chr1_193053785_ENST00000367443_CDC73_chr1_193218858_ENST00000367435_length(amino acids)=573AA_BP=0
MEESVNQMQPLNEKQIANSQDGYVWQVTDMNRLHRFLCFGSEGGTYYIKEQKLGLENAEALIRLIEDGRGCEVIQEIKSFSQEGRTTKQE
PMLFALAICSQCSDISTKQAAFKAVSEVCRIPTHLFTFIQFKKDLKESMKCGMWGRALRKAIADWYNEKGGMALALAVTKYKQRNGWSHK
DLLRLSHLKPSSEGLAIVTKYITKGWKEVHELYKEKALSVETEKLLKYLEAVEKVKRTRDELEVIHLIEEHRLVREHLLTNHLKSKEVWK
ALLQEMPLTALLRNLGKMTANSVLEPGNSEVSLVCEKLCNEKLLKKARIHPFHILIALETYKTGHGLRGKLKWRPDEEILKALDAAFYKT
FKTVEPTGKRFLLAVDVSASMNQRVLGSILNASTVAAAMCMVVTRTEKDSYVVAFSDEMVPCPVTTDMTLQQVLMAMSQIPAGGTDCSLP
MIWAQKTNTPADVFIVFTDNETFAGGVHPAIALREYRKKMDIPAKLIVCGMTSNGFTIADPDDRVKAFHLKYDEVRLDPNVQKWDVTVLE

--------------------------------------------------------------
>94333_94333_2_TROVE2-CDC73_TROVE2_chr1_193053785_ENST00000367444_CDC73_chr1_193218858_ENST00000367435_length(transcript)=5098nt_BP=1730nt
CACAGGCCGACGTCGAGAGGGCCTGCTTTACTCCTCCTCTTTCTCCTCCTTCTCCCGCGGCTTCTGCGCGGAGAGGCGTCGCCCGGGATC
TGGGTTTTGGAAGAAGGATCTTTGTGGGAAGACAGGGTGAATTTATCACAGAGGAATAACGAGGGAGAGGAGAAAGGTTTCCTAAAGACA
AAAAAAAATGGAGGAATCTGTAAACCAAATGCAGCCACTGAATGAGAAGCAGATAGCCAATTCTCAGGATGGATATGTATGGCAAGTCAC
TGACATGAATCGACTACACCGGTTCTTATGTTTCGGTTCTGAAGGTGGGACTTATTATATCAAAGAACAGAAGTTGGGCCTTGAAAATGC
TGAAGCTTTAATTAGATTGATTGAAGATGGCAGAGGATGTGAAGTGATACAAGAAATAAAGTCATTTAGTCAAGAAGGCAGAACCACAAA
GCAAGAGCCTATGCTCTTTGCACTTGCCATTTGTTCCCAGTGCTCCGACATAAGCACAAAACAAGCAGCATTTAAAGCTGTTTCTGAAGT
TTGTCGCATTCCTACCCATCTCTTTACTTTTATCCAGTTTAAGAAAGATCTGAAGGAAAGCATGAAATGTGGCATGTGGGGTCGTGCCCT
CCGGAAGGCTATAGCGGACTGGTACAATGAGAAAGGTGGCATGGCCCTTGCTCTGGCAGTTACAAAATATAAACAGAGAAATGGCTGGTC
TCACAAAGATCTATTAAGATTGTCACATCTTAAACCTTCCAGTGAAGGACTTGCAATTGTGACCAAATATATTACAAAGGGCTGGAAAGA
AGTTCATGAATTGTATAAAGAAAAAGCACTCTCTGTGGAGACTGAAAAATTATTAAAGTATCTGGAGGCTGTAGAGAAAGTGAAGCGCAC
AAGAGATGAGCTAGAAGTCATTCATCTAATAGAAGAACATAGATTAGTTAGAGAACATCTTTTAACAAATCACTTAAAGTCTAAAGAGGT
ATGGAAGGCTTTGTTACAAGAAATGCCGCTTACTGCATTACTAAGGAATCTAGGAAAGATGACTGCTAATTCAGTACTTGAACCAGGAAA
TTCAGAAGTATCTTTAGTATGTGAAAAACTGTGTAATGAAAAACTATTAAAAAAGGCTCGTATACATCCATTTCATATTTTGATCGCATT
AGAAACTTACAAGACAGGTCATGGTCTCAGAGGGAAACTGAAGTGGCGCCCTGATGAAGAAATTTTGAAAGCATTGGATGCTGCTTTTTA
TAAAACATTTAAGACAGTTGAACCAACTGGAAAACGTTTCTTACTAGCTGTTGATGTCAGTGCTTCTATGAACCAAAGAGTTTTGGGTAG
TATACTCAACGCTAGTACAGTTGCTGCAGCAATGTGCATGGTTGTCACACGAACAGAAAAAGATTCTTATGTAGTTGCTTTTTCCGATGA
AATGGTACCATGTCCAGTGACTACAGATATGACCTTACAACAGGTTTTAATGGCTATGAGTCAGATCCCAGCAGGTGGAACTGATTGCTC
TCTTCCAATGATCTGGGCTCAGAAGACAAACACACCTGCTGATGTCTTCATTGTATTCACTGATAATGAGACCTTTGCTGGAGGTGTCCA
TCCTGCTATTGCTCTGAGGGAGTATCGAAAGAAAATGGATATTCCAGCTAAATTGATTGTTTGTGGAATGACATCAAATGGTTTCACCAT
TGCAGACCCAGATGATAGAGTTAAAGCCTTCCATCTGAAGTATGATGAAGTTCGTCTGGATCCAAATGTTCAGAAATGGGATGTAACAGT
ATTAGAACTCAGCTATCACAAACGTCATTTGGATAGACCAGTGTTCTTACGGTTTTGGGAAACATTGGACAGGTACATGGTAAAGCATAA
ATCGCACTTGAGATTCTGAATTATTTGGCTCCTCCATTTCTGGAAATTGAGACTCAAGCTTTATGAATTTATCAAGAACTTAAAAATGAA
GAAGGTCACAGATTGATCTTTTATAAGACCTTATTTGATGCTTTGTGCTTCAAGGAGATGATACCTGTCATCCATATAAGCAAACTTTTT
GGCTTACAACTATTTTTTTAATATTAGCCTTCTAGTCTGTAATGGAAATTGTATATTTTGATAGAAGTTTTTTCTCCATTGGTTAAATTA
GCATTACTTAAAATTTGTTTCTTTAGAAAATAAATGCAGGTTATAAATGTGTGTATATTTAGAGATTATAAGGCTCTCTGAGCCATCTTC
TGATTTTTCATTGCTCTATAATTCTTTTTACTGAAAATACTATGTTATGAATGGTATTAAATTTTAGTCTCTGGAACATCCAAAACCAAG
CAAAGGGATGTGACTATTTTGAATGAATCAGAATGTCAACTTGTATGTACACTATATCTACACTTACTCATTATTTAAAAAGAATAATGA
AAAATCTAGATCAATTCTTCAATTTGATTGAACTGTTCAGCCTTTTCAAGATTTCTTTATTTACAAATGATTACATTTAAATGAATGTAC
ATTCTTCTCACTGACTTTGGTGATTTTGAAACCTAGAATGATGTGTTTCTATCTGTAATATCTTTCCATTTGAAAAAAATCTCAAAACAC
AGATTAAAACCACAATAGGCTGTAGTATTTTTTATTTTGGGAGCCAGAGTATGATTTGGGGGAAGAATATGTATCAGCCCTATTGCAGTA
TAACTTTAAGCTCCTTTTCTCTTTAGTCCACTTTTGATTGTAATTTTTATGGTATAGGATTTTGAATCTTCTATTTTAGGCTTGTCAGTC
TTGGAGTTCTTATCTTCCATTATCCCTAAATATTGATAAACTCCCAGGCACCAAAGAAAACATTTGCTTAATTGTCTGAAAAGAAACAAG
AGAAAAACACTGGTATTTTTATGTCTGTATTCAATATGGTATAAAATATAAAAACTATATTTTAACTTAGTGAAATATTTTACTATTTCT
CTACTTCAGACAAAATGTTGCATCCAAGGTACATCAAGTGACCATTTGCCTTGAACCTTGATTTCACTTTGTTTTTTTTTTTTCCTTAAA
GGCAACTAGGAAGCTTTACTTTCCTAAAGTGTTTTTGCCATTGGAATTTTTGCTGATCACAGTCTTATGTCATTTTTTTCTCTGTTTTTA
TTCCCAGCAATTTTCTCCTAGGTTAACATATTTTTGGTGAACGTTTAGGCCTTTCATAGGTATTAAGCTGACATTATCTAGCTTCTTAAT
GAAATTTAACACTGTCACAAAAATGAGAAGTTATTATTTTTTAAGTGATCACATAGTTCATACCACTAGTAACTAGAAAAGATATTTATT
CACATGATATTTACAAGGCTCTTCAGAAGGGAACAGTCAGCATTTTAAATTACTAGATTTTAGCATACTTAACAAGGTTTGAACAGATTC
TACCCCTATTTTCCTCCCTTTTTAGCGTCTTCTTTCCTTAAAGATAAAAGAAAACTCAAATTTGTTTACATTAGGCTTTCTTAGCATATA
AATATATTTCCAAAATAAATTACATGTTGTGTAAACTTTCTCCATGATGAAATAGTCAAGGACCAGAATCTGTAATATTTTTATGTAAGA
TTACTTGTCAAGACTACTACAAGTCAGTATGAACTACCTTCCCATAAAGATTTTTGGTATTTGTACTTATTTATGAACTTTACTTGAGAC
AGAATATGGTTAAAATTAGGAACATCTACTTTGAATGAGGTTTATTTTTCTATTTTGAATTTGCCTTATGTATATTCAAAGGCTTATGGA
AATACTGTAAAGGAACATTAGGAAAAGGACAAATAGGCTATAACCATCTATCTTAAAATCAGACCCTTAGTATAAGCACCTCTTTTTCTT
TTCCTCTTTGACAATTTAGTCTCTTATTTAGGTCCATGTAATTAATTTCATTCCATTATTTTTTAGCTGTTTATTCTAAAAAACAAAAAT
TTTCAGCCACTCCCATTTATTCTCCCATGACATGGTCCTATATAGCAGTACTTAACACAGTGCCTTGCACATAGTAGGCATTCAGTAAAT
ACTTACATGCATGAATGAATAATGTATTTTCAGTGTAACAAATTTATTATAAAAGTGTAGTTCGACTCTTCTTGGTCTTGGAGTTTGAGA
GTACAGAATTACAGGGAATGAAGAGAGGTATAAGTAGATATTTTAATGGAAATGAAGTATAAATTAATAACTTGACTTACCCCTCCATAA
GTTACTGCTAACTGGAGATACCCTTGTATGCCCAACCTGTAAAGGAAAAAGTTCTATTTCTATATTTATAGGACATTCTTCTCAGTCAAG
GAACAGTAAGAAATATGTAGGTTTCAATCAGTTGCTCTCAACCCTGACTGCATTTTAGAATCATTTGGAGAGTTTTTAAAAATATCCATG
CCTGAATCTTGATTCCCATTTTCATGTAATTTGAGACAAGACCTGGTCATCAGTATTTTTTTTAAAGTTCTCCAGGTAATTTGAATGTGC
AGGAAGGATTCAGAATCACTGGTTTAATTTGTTATTGAAAACAGTACCAGTATTAAATGTGTTTCCTCTTCCTTCTTTTCTGTATGTATG
TGTGGTTTTTGATTTTTTGTTGTTGTTGTTGTTTTGTGGCCACCCTTTGCACTAGACCATCCCTTTTATTGGTGGTATTGGCCTATATTC
CCATTGACAAATGCAATTTTTAATTATTTATTTAATATAGGAGTATTTTACTGTTTAATATTTAAACAATGTTTAATGTATTTCATTATT
AACTAGTATTATAGTTTGTTTTTTTCCCATGTCTCCATAACTTTTACTAACATTTGTTTTTAGCAGCACAACAGTAATCCATATAAAAAC
AACTAATTCATAATGAGGAAAATCTCATAATTTTTAAGGCAGAAAGAAGTATTAATTTTTGATCTGCCATGTAGAATGAGACAAATACAG
TTTGCTTATGAAAGGAAAGTGGCATACTTTTAAATTGGTCTACACAGAAAAGTAAAAGTAAACTATTCATTTAAATAAGATTCATTATCT

>94333_94333_2_TROVE2-CDC73_TROVE2_chr1_193053785_ENST00000367444_CDC73_chr1_193218858_ENST00000367435_length(amino acids)=573AA_BP=0
MEESVNQMQPLNEKQIANSQDGYVWQVTDMNRLHRFLCFGSEGGTYYIKEQKLGLENAEALIRLIEDGRGCEVIQEIKSFSQEGRTTKQE
PMLFALAICSQCSDISTKQAAFKAVSEVCRIPTHLFTFIQFKKDLKESMKCGMWGRALRKAIADWYNEKGGMALALAVTKYKQRNGWSHK
DLLRLSHLKPSSEGLAIVTKYITKGWKEVHELYKEKALSVETEKLLKYLEAVEKVKRTRDELEVIHLIEEHRLVREHLLTNHLKSKEVWK
ALLQEMPLTALLRNLGKMTANSVLEPGNSEVSLVCEKLCNEKLLKKARIHPFHILIALETYKTGHGLRGKLKWRPDEEILKALDAAFYKT
FKTVEPTGKRFLLAVDVSASMNQRVLGSILNASTVAAAMCMVVTRTEKDSYVVAFSDEMVPCPVTTDMTLQQVLMAMSQIPAGGTDCSLP
MIWAQKTNTPADVFIVFTDNETFAGGVHPAIALREYRKKMDIPAKLIVCGMTSNGFTIADPDDRVKAFHLKYDEVRLDPNVQKWDVTVLE

--------------------------------------------------------------
>94333_94333_3_TROVE2-CDC73_TROVE2_chr1_193053787_ENST00000367443_CDC73_chr1_193218860_ENST00000367435_length(transcript)=5098nt_BP=1730nt
CACAGGCCGACGTCGAGAGGGCCTGCTTTACTCCTCCTCTTTCTCCTCCTTCTCCCGCGGCTTCTGCGCGGAGAGGCGTCGCCCGGGATC
TGGGTTTTGGAAGAAGGATCTTTGTGGGAAGACAGGGTGAATTTATCACAGAGGAATAACGAGGGAGAGGAGAAAGGTTTCCTAAAGACA
AAAAAAAATGGAGGAATCTGTAAACCAAATGCAGCCACTGAATGAGAAGCAGATAGCCAATTCTCAGGATGGATATGTATGGCAAGTCAC
TGACATGAATCGACTACACCGGTTCTTATGTTTCGGTTCTGAAGGTGGGACTTATTATATCAAAGAACAGAAGTTGGGCCTTGAAAATGC
TGAAGCTTTAATTAGATTGATTGAAGATGGCAGAGGATGTGAAGTGATACAAGAAATAAAGTCATTTAGTCAAGAAGGCAGAACCACAAA
GCAAGAGCCTATGCTCTTTGCACTTGCCATTTGTTCCCAGTGCTCCGACATAAGCACAAAACAAGCAGCATTTAAAGCTGTTTCTGAAGT
TTGTCGCATTCCTACCCATCTCTTTACTTTTATCCAGTTTAAGAAAGATCTGAAGGAAAGCATGAAATGTGGCATGTGGGGTCGTGCCCT
CCGGAAGGCTATAGCGGACTGGTACAATGAGAAAGGTGGCATGGCCCTTGCTCTGGCAGTTACAAAATATAAACAGAGAAATGGCTGGTC
TCACAAAGATCTATTAAGATTGTCACATCTTAAACCTTCCAGTGAAGGACTTGCAATTGTGACCAAATATATTACAAAGGGCTGGAAAGA
AGTTCATGAATTGTATAAAGAAAAAGCACTCTCTGTGGAGACTGAAAAATTATTAAAGTATCTGGAGGCTGTAGAGAAAGTGAAGCGCAC
AAGAGATGAGCTAGAAGTCATTCATCTAATAGAAGAACATAGATTAGTTAGAGAACATCTTTTAACAAATCACTTAAAGTCTAAAGAGGT
ATGGAAGGCTTTGTTACAAGAAATGCCGCTTACTGCATTACTAAGGAATCTAGGAAAGATGACTGCTAATTCAGTACTTGAACCAGGAAA
TTCAGAAGTATCTTTAGTATGTGAAAAACTGTGTAATGAAAAACTATTAAAAAAGGCTCGTATACATCCATTTCATATTTTGATCGCATT
AGAAACTTACAAGACAGGTCATGGTCTCAGAGGGAAACTGAAGTGGCGCCCTGATGAAGAAATTTTGAAAGCATTGGATGCTGCTTTTTA
TAAAACATTTAAGACAGTTGAACCAACTGGAAAACGTTTCTTACTAGCTGTTGATGTCAGTGCTTCTATGAACCAAAGAGTTTTGGGTAG
TATACTCAACGCTAGTACAGTTGCTGCAGCAATGTGCATGGTTGTCACACGAACAGAAAAAGATTCTTATGTAGTTGCTTTTTCCGATGA
AATGGTACCATGTCCAGTGACTACAGATATGACCTTACAACAGGTTTTAATGGCTATGAGTCAGATCCCAGCAGGTGGAACTGATTGCTC
TCTTCCAATGATCTGGGCTCAGAAGACAAACACACCTGCTGATGTCTTCATTGTATTCACTGATAATGAGACCTTTGCTGGAGGTGTCCA
TCCTGCTATTGCTCTGAGGGAGTATCGAAAGAAAATGGATATTCCAGCTAAATTGATTGTTTGTGGAATGACATCAAATGGTTTCACCAT
TGCAGACCCAGATGATAGAGTTAAAGCCTTCCATCTGAAGTATGATGAAGTTCGTCTGGATCCAAATGTTCAGAAATGGGATGTAACAGT
ATTAGAACTCAGCTATCACAAACGTCATTTGGATAGACCAGTGTTCTTACGGTTTTGGGAAACATTGGACAGGTACATGGTAAAGCATAA
ATCGCACTTGAGATTCTGAATTATTTGGCTCCTCCATTTCTGGAAATTGAGACTCAAGCTTTATGAATTTATCAAGAACTTAAAAATGAA
GAAGGTCACAGATTGATCTTTTATAAGACCTTATTTGATGCTTTGTGCTTCAAGGAGATGATACCTGTCATCCATATAAGCAAACTTTTT
GGCTTACAACTATTTTTTTAATATTAGCCTTCTAGTCTGTAATGGAAATTGTATATTTTGATAGAAGTTTTTTCTCCATTGGTTAAATTA
GCATTACTTAAAATTTGTTTCTTTAGAAAATAAATGCAGGTTATAAATGTGTGTATATTTAGAGATTATAAGGCTCTCTGAGCCATCTTC
TGATTTTTCATTGCTCTATAATTCTTTTTACTGAAAATACTATGTTATGAATGGTATTAAATTTTAGTCTCTGGAACATCCAAAACCAAG
CAAAGGGATGTGACTATTTTGAATGAATCAGAATGTCAACTTGTATGTACACTATATCTACACTTACTCATTATTTAAAAAGAATAATGA
AAAATCTAGATCAATTCTTCAATTTGATTGAACTGTTCAGCCTTTTCAAGATTTCTTTATTTACAAATGATTACATTTAAATGAATGTAC
ATTCTTCTCACTGACTTTGGTGATTTTGAAACCTAGAATGATGTGTTTCTATCTGTAATATCTTTCCATTTGAAAAAAATCTCAAAACAC
AGATTAAAACCACAATAGGCTGTAGTATTTTTTATTTTGGGAGCCAGAGTATGATTTGGGGGAAGAATATGTATCAGCCCTATTGCAGTA
TAACTTTAAGCTCCTTTTCTCTTTAGTCCACTTTTGATTGTAATTTTTATGGTATAGGATTTTGAATCTTCTATTTTAGGCTTGTCAGTC
TTGGAGTTCTTATCTTCCATTATCCCTAAATATTGATAAACTCCCAGGCACCAAAGAAAACATTTGCTTAATTGTCTGAAAAGAAACAAG
AGAAAAACACTGGTATTTTTATGTCTGTATTCAATATGGTATAAAATATAAAAACTATATTTTAACTTAGTGAAATATTTTACTATTTCT
CTACTTCAGACAAAATGTTGCATCCAAGGTACATCAAGTGACCATTTGCCTTGAACCTTGATTTCACTTTGTTTTTTTTTTTTCCTTAAA
GGCAACTAGGAAGCTTTACTTTCCTAAAGTGTTTTTGCCATTGGAATTTTTGCTGATCACAGTCTTATGTCATTTTTTTCTCTGTTTTTA
TTCCCAGCAATTTTCTCCTAGGTTAACATATTTTTGGTGAACGTTTAGGCCTTTCATAGGTATTAAGCTGACATTATCTAGCTTCTTAAT
GAAATTTAACACTGTCACAAAAATGAGAAGTTATTATTTTTTAAGTGATCACATAGTTCATACCACTAGTAACTAGAAAAGATATTTATT
CACATGATATTTACAAGGCTCTTCAGAAGGGAACAGTCAGCATTTTAAATTACTAGATTTTAGCATACTTAACAAGGTTTGAACAGATTC
TACCCCTATTTTCCTCCCTTTTTAGCGTCTTCTTTCCTTAAAGATAAAAGAAAACTCAAATTTGTTTACATTAGGCTTTCTTAGCATATA
AATATATTTCCAAAATAAATTACATGTTGTGTAAACTTTCTCCATGATGAAATAGTCAAGGACCAGAATCTGTAATATTTTTATGTAAGA
TTACTTGTCAAGACTACTACAAGTCAGTATGAACTACCTTCCCATAAAGATTTTTGGTATTTGTACTTATTTATGAACTTTACTTGAGAC
AGAATATGGTTAAAATTAGGAACATCTACTTTGAATGAGGTTTATTTTTCTATTTTGAATTTGCCTTATGTATATTCAAAGGCTTATGGA
AATACTGTAAAGGAACATTAGGAAAAGGACAAATAGGCTATAACCATCTATCTTAAAATCAGACCCTTAGTATAAGCACCTCTTTTTCTT
TTCCTCTTTGACAATTTAGTCTCTTATTTAGGTCCATGTAATTAATTTCATTCCATTATTTTTTAGCTGTTTATTCTAAAAAACAAAAAT
TTTCAGCCACTCCCATTTATTCTCCCATGACATGGTCCTATATAGCAGTACTTAACACAGTGCCTTGCACATAGTAGGCATTCAGTAAAT
ACTTACATGCATGAATGAATAATGTATTTTCAGTGTAACAAATTTATTATAAAAGTGTAGTTCGACTCTTCTTGGTCTTGGAGTTTGAGA
GTACAGAATTACAGGGAATGAAGAGAGGTATAAGTAGATATTTTAATGGAAATGAAGTATAAATTAATAACTTGACTTACCCCTCCATAA
GTTACTGCTAACTGGAGATACCCTTGTATGCCCAACCTGTAAAGGAAAAAGTTCTATTTCTATATTTATAGGACATTCTTCTCAGTCAAG
GAACAGTAAGAAATATGTAGGTTTCAATCAGTTGCTCTCAACCCTGACTGCATTTTAGAATCATTTGGAGAGTTTTTAAAAATATCCATG
CCTGAATCTTGATTCCCATTTTCATGTAATTTGAGACAAGACCTGGTCATCAGTATTTTTTTTAAAGTTCTCCAGGTAATTTGAATGTGC
AGGAAGGATTCAGAATCACTGGTTTAATTTGTTATTGAAAACAGTACCAGTATTAAATGTGTTTCCTCTTCCTTCTTTTCTGTATGTATG
TGTGGTTTTTGATTTTTTGTTGTTGTTGTTGTTTTGTGGCCACCCTTTGCACTAGACCATCCCTTTTATTGGTGGTATTGGCCTATATTC
CCATTGACAAATGCAATTTTTAATTATTTATTTAATATAGGAGTATTTTACTGTTTAATATTTAAACAATGTTTAATGTATTTCATTATT
AACTAGTATTATAGTTTGTTTTTTTCCCATGTCTCCATAACTTTTACTAACATTTGTTTTTAGCAGCACAACAGTAATCCATATAAAAAC
AACTAATTCATAATGAGGAAAATCTCATAATTTTTAAGGCAGAAAGAAGTATTAATTTTTGATCTGCCATGTAGAATGAGACAAATACAG
TTTGCTTATGAAAGGAAAGTGGCATACTTTTAAATTGGTCTACACAGAAAAGTAAAAGTAAACTATTCATTTAAATAAGATTCATTATCT

>94333_94333_3_TROVE2-CDC73_TROVE2_chr1_193053787_ENST00000367443_CDC73_chr1_193218860_ENST00000367435_length(amino acids)=573AA_BP=0
MEESVNQMQPLNEKQIANSQDGYVWQVTDMNRLHRFLCFGSEGGTYYIKEQKLGLENAEALIRLIEDGRGCEVIQEIKSFSQEGRTTKQE
PMLFALAICSQCSDISTKQAAFKAVSEVCRIPTHLFTFIQFKKDLKESMKCGMWGRALRKAIADWYNEKGGMALALAVTKYKQRNGWSHK
DLLRLSHLKPSSEGLAIVTKYITKGWKEVHELYKEKALSVETEKLLKYLEAVEKVKRTRDELEVIHLIEEHRLVREHLLTNHLKSKEVWK
ALLQEMPLTALLRNLGKMTANSVLEPGNSEVSLVCEKLCNEKLLKKARIHPFHILIALETYKTGHGLRGKLKWRPDEEILKALDAAFYKT
FKTVEPTGKRFLLAVDVSASMNQRVLGSILNASTVAAAMCMVVTRTEKDSYVVAFSDEMVPCPVTTDMTLQQVLMAMSQIPAGGTDCSLP
MIWAQKTNTPADVFIVFTDNETFAGGVHPAIALREYRKKMDIPAKLIVCGMTSNGFTIADPDDRVKAFHLKYDEVRLDPNVQKWDVTVLE

--------------------------------------------------------------
>94333_94333_4_TROVE2-CDC73_TROVE2_chr1_193053787_ENST00000367444_CDC73_chr1_193218860_ENST00000367435_length(transcript)=5098nt_BP=1730nt
CACAGGCCGACGTCGAGAGGGCCTGCTTTACTCCTCCTCTTTCTCCTCCTTCTCCCGCGGCTTCTGCGCGGAGAGGCGTCGCCCGGGATC
TGGGTTTTGGAAGAAGGATCTTTGTGGGAAGACAGGGTGAATTTATCACAGAGGAATAACGAGGGAGAGGAGAAAGGTTTCCTAAAGACA
AAAAAAAATGGAGGAATCTGTAAACCAAATGCAGCCACTGAATGAGAAGCAGATAGCCAATTCTCAGGATGGATATGTATGGCAAGTCAC
TGACATGAATCGACTACACCGGTTCTTATGTTTCGGTTCTGAAGGTGGGACTTATTATATCAAAGAACAGAAGTTGGGCCTTGAAAATGC
TGAAGCTTTAATTAGATTGATTGAAGATGGCAGAGGATGTGAAGTGATACAAGAAATAAAGTCATTTAGTCAAGAAGGCAGAACCACAAA
GCAAGAGCCTATGCTCTTTGCACTTGCCATTTGTTCCCAGTGCTCCGACATAAGCACAAAACAAGCAGCATTTAAAGCTGTTTCTGAAGT
TTGTCGCATTCCTACCCATCTCTTTACTTTTATCCAGTTTAAGAAAGATCTGAAGGAAAGCATGAAATGTGGCATGTGGGGTCGTGCCCT
CCGGAAGGCTATAGCGGACTGGTACAATGAGAAAGGTGGCATGGCCCTTGCTCTGGCAGTTACAAAATATAAACAGAGAAATGGCTGGTC
TCACAAAGATCTATTAAGATTGTCACATCTTAAACCTTCCAGTGAAGGACTTGCAATTGTGACCAAATATATTACAAAGGGCTGGAAAGA
AGTTCATGAATTGTATAAAGAAAAAGCACTCTCTGTGGAGACTGAAAAATTATTAAAGTATCTGGAGGCTGTAGAGAAAGTGAAGCGCAC
AAGAGATGAGCTAGAAGTCATTCATCTAATAGAAGAACATAGATTAGTTAGAGAACATCTTTTAACAAATCACTTAAAGTCTAAAGAGGT
ATGGAAGGCTTTGTTACAAGAAATGCCGCTTACTGCATTACTAAGGAATCTAGGAAAGATGACTGCTAATTCAGTACTTGAACCAGGAAA
TTCAGAAGTATCTTTAGTATGTGAAAAACTGTGTAATGAAAAACTATTAAAAAAGGCTCGTATACATCCATTTCATATTTTGATCGCATT
AGAAACTTACAAGACAGGTCATGGTCTCAGAGGGAAACTGAAGTGGCGCCCTGATGAAGAAATTTTGAAAGCATTGGATGCTGCTTTTTA
TAAAACATTTAAGACAGTTGAACCAACTGGAAAACGTTTCTTACTAGCTGTTGATGTCAGTGCTTCTATGAACCAAAGAGTTTTGGGTAG
TATACTCAACGCTAGTACAGTTGCTGCAGCAATGTGCATGGTTGTCACACGAACAGAAAAAGATTCTTATGTAGTTGCTTTTTCCGATGA
AATGGTACCATGTCCAGTGACTACAGATATGACCTTACAACAGGTTTTAATGGCTATGAGTCAGATCCCAGCAGGTGGAACTGATTGCTC
TCTTCCAATGATCTGGGCTCAGAAGACAAACACACCTGCTGATGTCTTCATTGTATTCACTGATAATGAGACCTTTGCTGGAGGTGTCCA
TCCTGCTATTGCTCTGAGGGAGTATCGAAAGAAAATGGATATTCCAGCTAAATTGATTGTTTGTGGAATGACATCAAATGGTTTCACCAT
TGCAGACCCAGATGATAGAGTTAAAGCCTTCCATCTGAAGTATGATGAAGTTCGTCTGGATCCAAATGTTCAGAAATGGGATGTAACAGT
ATTAGAACTCAGCTATCACAAACGTCATTTGGATAGACCAGTGTTCTTACGGTTTTGGGAAACATTGGACAGGTACATGGTAAAGCATAA
ATCGCACTTGAGATTCTGAATTATTTGGCTCCTCCATTTCTGGAAATTGAGACTCAAGCTTTATGAATTTATCAAGAACTTAAAAATGAA
GAAGGTCACAGATTGATCTTTTATAAGACCTTATTTGATGCTTTGTGCTTCAAGGAGATGATACCTGTCATCCATATAAGCAAACTTTTT
GGCTTACAACTATTTTTTTAATATTAGCCTTCTAGTCTGTAATGGAAATTGTATATTTTGATAGAAGTTTTTTCTCCATTGGTTAAATTA
GCATTACTTAAAATTTGTTTCTTTAGAAAATAAATGCAGGTTATAAATGTGTGTATATTTAGAGATTATAAGGCTCTCTGAGCCATCTTC
TGATTTTTCATTGCTCTATAATTCTTTTTACTGAAAATACTATGTTATGAATGGTATTAAATTTTAGTCTCTGGAACATCCAAAACCAAG
CAAAGGGATGTGACTATTTTGAATGAATCAGAATGTCAACTTGTATGTACACTATATCTACACTTACTCATTATTTAAAAAGAATAATGA
AAAATCTAGATCAATTCTTCAATTTGATTGAACTGTTCAGCCTTTTCAAGATTTCTTTATTTACAAATGATTACATTTAAATGAATGTAC
ATTCTTCTCACTGACTTTGGTGATTTTGAAACCTAGAATGATGTGTTTCTATCTGTAATATCTTTCCATTTGAAAAAAATCTCAAAACAC
AGATTAAAACCACAATAGGCTGTAGTATTTTTTATTTTGGGAGCCAGAGTATGATTTGGGGGAAGAATATGTATCAGCCCTATTGCAGTA
TAACTTTAAGCTCCTTTTCTCTTTAGTCCACTTTTGATTGTAATTTTTATGGTATAGGATTTTGAATCTTCTATTTTAGGCTTGTCAGTC
TTGGAGTTCTTATCTTCCATTATCCCTAAATATTGATAAACTCCCAGGCACCAAAGAAAACATTTGCTTAATTGTCTGAAAAGAAACAAG
AGAAAAACACTGGTATTTTTATGTCTGTATTCAATATGGTATAAAATATAAAAACTATATTTTAACTTAGTGAAATATTTTACTATTTCT
CTACTTCAGACAAAATGTTGCATCCAAGGTACATCAAGTGACCATTTGCCTTGAACCTTGATTTCACTTTGTTTTTTTTTTTTCCTTAAA
GGCAACTAGGAAGCTTTACTTTCCTAAAGTGTTTTTGCCATTGGAATTTTTGCTGATCACAGTCTTATGTCATTTTTTTCTCTGTTTTTA
TTCCCAGCAATTTTCTCCTAGGTTAACATATTTTTGGTGAACGTTTAGGCCTTTCATAGGTATTAAGCTGACATTATCTAGCTTCTTAAT
GAAATTTAACACTGTCACAAAAATGAGAAGTTATTATTTTTTAAGTGATCACATAGTTCATACCACTAGTAACTAGAAAAGATATTTATT
CACATGATATTTACAAGGCTCTTCAGAAGGGAACAGTCAGCATTTTAAATTACTAGATTTTAGCATACTTAACAAGGTTTGAACAGATTC
TACCCCTATTTTCCTCCCTTTTTAGCGTCTTCTTTCCTTAAAGATAAAAGAAAACTCAAATTTGTTTACATTAGGCTTTCTTAGCATATA
AATATATTTCCAAAATAAATTACATGTTGTGTAAACTTTCTCCATGATGAAATAGTCAAGGACCAGAATCTGTAATATTTTTATGTAAGA
TTACTTGTCAAGACTACTACAAGTCAGTATGAACTACCTTCCCATAAAGATTTTTGGTATTTGTACTTATTTATGAACTTTACTTGAGAC
AGAATATGGTTAAAATTAGGAACATCTACTTTGAATGAGGTTTATTTTTCTATTTTGAATTTGCCTTATGTATATTCAAAGGCTTATGGA
AATACTGTAAAGGAACATTAGGAAAAGGACAAATAGGCTATAACCATCTATCTTAAAATCAGACCCTTAGTATAAGCACCTCTTTTTCTT
TTCCTCTTTGACAATTTAGTCTCTTATTTAGGTCCATGTAATTAATTTCATTCCATTATTTTTTAGCTGTTTATTCTAAAAAACAAAAAT
TTTCAGCCACTCCCATTTATTCTCCCATGACATGGTCCTATATAGCAGTACTTAACACAGTGCCTTGCACATAGTAGGCATTCAGTAAAT
ACTTACATGCATGAATGAATAATGTATTTTCAGTGTAACAAATTTATTATAAAAGTGTAGTTCGACTCTTCTTGGTCTTGGAGTTTGAGA
GTACAGAATTACAGGGAATGAAGAGAGGTATAAGTAGATATTTTAATGGAAATGAAGTATAAATTAATAACTTGACTTACCCCTCCATAA
GTTACTGCTAACTGGAGATACCCTTGTATGCCCAACCTGTAAAGGAAAAAGTTCTATTTCTATATTTATAGGACATTCTTCTCAGTCAAG
GAACAGTAAGAAATATGTAGGTTTCAATCAGTTGCTCTCAACCCTGACTGCATTTTAGAATCATTTGGAGAGTTTTTAAAAATATCCATG
CCTGAATCTTGATTCCCATTTTCATGTAATTTGAGACAAGACCTGGTCATCAGTATTTTTTTTAAAGTTCTCCAGGTAATTTGAATGTGC
AGGAAGGATTCAGAATCACTGGTTTAATTTGTTATTGAAAACAGTACCAGTATTAAATGTGTTTCCTCTTCCTTCTTTTCTGTATGTATG
TGTGGTTTTTGATTTTTTGTTGTTGTTGTTGTTTTGTGGCCACCCTTTGCACTAGACCATCCCTTTTATTGGTGGTATTGGCCTATATTC
CCATTGACAAATGCAATTTTTAATTATTTATTTAATATAGGAGTATTTTACTGTTTAATATTTAAACAATGTTTAATGTATTTCATTATT
AACTAGTATTATAGTTTGTTTTTTTCCCATGTCTCCATAACTTTTACTAACATTTGTTTTTAGCAGCACAACAGTAATCCATATAAAAAC
AACTAATTCATAATGAGGAAAATCTCATAATTTTTAAGGCAGAAAGAAGTATTAATTTTTGATCTGCCATGTAGAATGAGACAAATACAG
TTTGCTTATGAAAGGAAAGTGGCATACTTTTAAATTGGTCTACACAGAAAAGTAAAAGTAAACTATTCATTTAAATAAGATTCATTATCT

>94333_94333_4_TROVE2-CDC73_TROVE2_chr1_193053787_ENST00000367444_CDC73_chr1_193218860_ENST00000367435_length(amino acids)=573AA_BP=0
MEESVNQMQPLNEKQIANSQDGYVWQVTDMNRLHRFLCFGSEGGTYYIKEQKLGLENAEALIRLIEDGRGCEVIQEIKSFSQEGRTTKQE
PMLFALAICSQCSDISTKQAAFKAVSEVCRIPTHLFTFIQFKKDLKESMKCGMWGRALRKAIADWYNEKGGMALALAVTKYKQRNGWSHK
DLLRLSHLKPSSEGLAIVTKYITKGWKEVHELYKEKALSVETEKLLKYLEAVEKVKRTRDELEVIHLIEEHRLVREHLLTNHLKSKEVWK
ALLQEMPLTALLRNLGKMTANSVLEPGNSEVSLVCEKLCNEKLLKKARIHPFHILIALETYKTGHGLRGKLKWRPDEEILKALDAAFYKT
FKTVEPTGKRFLLAVDVSASMNQRVLGSILNASTVAAAMCMVVTRTEKDSYVVAFSDEMVPCPVTTDMTLQQVLMAMSQIPAGGTDCSLP
MIWAQKTNTPADVFIVFTDNETFAGGVHPAIALREYRKKMDIPAKLIVCGMTSNGFTIADPDDRVKAFHLKYDEVRLDPNVQKWDVTVLE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for TROVE2-CDC73


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneCDC73chr1:193053785chr1:193218858ENST000003674351417200_250472.3333333333333532.0CTNNB1
TgeneCDC73chr1:193053787chr1:193218860ENST000003674351417200_250472.3333333333333532.0CTNNB1
TgeneCDC73chr1:193053785chr1:193218858ENST000003674351417200_531472.3333333333333532.0POLR2A and PAF1
TgeneCDC73chr1:193053787chr1:193218860ENST000003674351417200_531472.3333333333333532.0POLR2A and PAF1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for TROVE2-CDC73


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for TROVE2-CDC73


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC1704981Hyperparathyroidism-Jaw Tumor Syndrome9CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC1840402HYPERPARATHYROIDISM 16CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0687150Parathyroid Gland Adenocarcinoma2CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneC4551961Familial Isolated Hyperparathyroidism1CTD_human;ORPHANET