Fusion Gene Studies
in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BRAF-AKAP9 (FusionGDB2 ID:HG673TG10142)

Fusion Gene Summary for BRAF-AKAP9

check button Fusion gene summary
Fusion gene informationFusion gene name: BRAF-AKAP9
Fusion gene ID: hg673tg10142
HgeneTgene
Gene symbol

BRAF

AKAP9

Gene ID

673

10142

Gene nameB-Raf proto-oncogene, serine/threonine kinaseA-kinase anchoring protein 9
SynonymsB-RAF1|B-raf|BRAF1|NS7|RAFB1AKAP-9|AKAP350|AKAP450|CG-NAP|HYPERION|LQT11|MU-RMS-40.16A|PPP1R45|PRKA9|YOTIAO
Cytomap('BRAF')('AKAP9')

7q34

7q21.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase B-raf94 kDa B-raf proteinB-Raf proto-oncogene serine/threonine-protein kinase (p94)B-Raf serine/threonine-proteinmurine sarcoma viral (v-raf) oncogene homolog B1proto-oncogene B-Rafv-raf murine sarcoma viral oncogene A-kinase anchor protein 9A kinase (PRKA) anchor protein (yotiao) 9A kinase (PRKA) anchor protein 9A-kinase anchor protein 350 kDaA-kinase anchor protein 450 kDaAKAP 120-like proteinAKAP9-BRAF fusion proteincentrosome- and Golgi-localized PKN-associ
Modification date2020032920200328
UniProtAcc

P15056

Q99996

Ensembl transtripts involved in fusion geneENST00000288602, ENST00000288602, 
Fusion gene scores* DoF score28 X 21 X 11=646811 X 17 X 7=1309
# samples 3215
** MAII scorelog2(32/6468*10)=-4.3371758685863
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1309*10)=-3.12543069144936
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BRAF [Title/Abstract] AND AKAP9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint
Anticipated loss of major functional domain due to fusion event.AKAP9-BRAF seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AKAP9-BRAF seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBRAF

GO:0000186

activation of MAPKK activity

29433126

HgeneBRAF

GO:0006468

protein phosphorylation

17563371

HgeneBRAF

GO:0010828

positive regulation of glucose transmembrane transport

23010278

HgeneBRAF

GO:0033138

positive regulation of peptidyl-serine phosphorylation

19667065

HgeneBRAF

GO:0043066

negative regulation of apoptotic process

19667065

HgeneBRAF

GO:0070374

positive regulation of ERK1 and ERK2 cascade

22065586

HgeneBRAF

GO:0071277

cellular response to calcium ion

18567582

HgeneBRAF

GO:0090150

establishment of protein localization to membrane

23010278

TgeneAKAP9

GO:0098962

regulation of postsynaptic neurotransmitter receptor activity

10390370

TgeneAKAP9

GO:1903358

regulation of Golgi organization

27666745



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerKB3..BRAFchr7

140494107

-AKAP9chr7

91641742

+


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Fusion Gene ORF analysis for BRAF-AKAP9

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000288602ENST00000394564BRAFchr7

140494107

-AKAP9chr7

91641742

+
5CDS-intronENST00000288602ENST00000491695BRAFchr7

140494107

-AKAP9chr7

91641742

+
In-frameENST00000288602ENST00000356239BRAFchr7

140494107

-AKAP9chr7

91641742

+
In-frameENST00000288602ENST00000358100BRAFchr7

140494107

-AKAP9chr7

91641742

+
In-frameENST00000288602ENST00000359028BRAFchr7

140494107

-AKAP9chr7

91641742

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000288602BRAFchr7140494107-ENST00000356239AKAP9chr791641742+1012112016196063181
ENST00000288602BRAFchr7140494107-ENST00000358100AKAP9chr791641742+993512016194203119
ENST00000288602BRAFchr7140494107-ENST00000359028AKAP9chr791641742+1009712016195823173

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for BRAF-AKAP9


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for BRAF-AKAP9


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:/chr7:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BRAF

P15056

AKAP9

Q99996

FUNCTION: Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000305}.FUNCTION: Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Required to maintain the integrity of the Golgi apparatus (PubMed:10202149, PubMed:15047863). Required for microtubule nucleation at the cis-side of the Golgi apparatus (PubMed:15047863, PubMed:19242490). Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase (PubMed:25657325). In complex with PDE4DIP isoform 13/MMG8/SMYLE, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with PDE4DIP isoform 13/MMG8/SMYLE, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension also from the centrosome to the cell periphery (PubMed:29162697). {ECO:0000269|PubMed:10202149, ECO:0000269|PubMed:15047863, ECO:0000269|PubMed:19242490, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:29162697}.; FUNCTION: [Isoform 4]: Associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations. {ECO:0000269|PubMed:9482789}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for BRAF-AKAP9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>10112_10112_1_BRAF-AKAP9_BRAF_chr7_140494107_ENST00000288602_AKAP9_chr7_91641742_ENST00000356239_length(transcript)=10121nt_BP=1201nt
CGCCTCCCTTCCCCCTCCCCGCCCGACAGCGGCCGCTCGGGCCCCGGCTCTCGGTTATAAGATGGCGGCGCTGAGCGGTGGCGGTGGTGG
CGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGCGCCGGCGCCGCGGCCTCTTCGGCTGCGGA
CCCTGCCATTCCGGAGGAGGTGTGGAATATCAAACAAATGATTAAGTTGACACAGGAACATATAGAGGCCCTATTGGACAAATTTGGTGG
GGAGCATAATCCACCATCAATATATCTGGAGGCCTATGAAGAATACACCAGCAAGCTAGATGCACTCCAACAAAGAGAACAACAGTTATT
GGAATCTCTGGGGAACGGAACTGATTTTTCTGTTTCTAGCTCTGCATCAATGGATACCGTTACATCTTCTTCCTCTTCTAGCCTTTCAGT
GCTACCTTCATCTCTTTCAGTTTTTCAAAATCCCACAGATGTGGCACGGAGCAACCCCAAGTCACCACAAAAACCTATCGTTAGAGTCTT
CCTGCCCAACAAACAGAGGACAGTGGTACCTGCAAGGTGTGGAGTTACAGTCCGAGACAGTCTAAAGAAAGCACTGATGATGAGAGGTCT
AATCCCAGAGTGCTGTGCTGTTTACAGAATTCAGGATGGAGAGAAGAAACCAATTGGTTGGGACACTGATATTTCCTGGCTTACTGGAGA
AGAATTGCATGTGGAAGTGTTGGAGAATGTTCCACTTACAACACACAACTTTGTACGAAAAACGTTTTTCACCTTAGCATTTTGTGACTT
TTGTCGAAAGCTGCTTTTCCAGGGTTTCCGCTGTCAAACATGTGGTTATAAATTTCACCAGCGTTGTAGTACAGAAGTTCCACTGATGTG
TGTTAATTATGACCAACTTGATTTGCTGTTTGTCTCCAAGTTCTTTGAACACCACCCAATACCACAGGAAGAGGCGTCCTTAGCAGAGAC
TGCCCTAACATCTGGATCATCCCCTTCCGCACCCGCCTCGGACTCTATTGGGCCCCAAATTCTCACCAGTCCGTCTCCTTCAAAATCCAT
TCCAATTCCACAGCCCTTCCGACCAGCAGATGAAGATCATCGAAATCAATTTGGGCAACGAGACCGATCCTCATCAGCTCCCAATGTGCA
TATAAACACAATAGAACCTGTCAATATTGATAATGATTTAAGGCTACAGATGGAAGCCCAACGCATTTGCCTCTCTCTGGTTTATTCAAC
TCATGTGGATCAGGTTCGTGAATATATGGAAAATGAAAAAGATAAAGCTCTTTGCAGTCTTAAAGAAGAGCTTATTTTTGCTCAAGAGGA
AAAGATCAAGGAACTTCAGAAAATACACCAGTTAGAACTACAGACTATGAAAACACAAGAAACAGGTGATGAAGGAAAGCCTTTACATCT
GCTCATTGGAAAACTTCAAAAGGCAGTGTCTGAAGAATGTTCTTATTTTTTACAGACTTTATGCAGTGTCCTTGGTGAATATTATACTCC
TGCTTTAAAATGTGAAGTAAATGCAGAAGACAAAGAGAATTCTGGTGATTACATTTCTGAAAATGAAGATCCAGAATTACAAGATTATAG
ATATGAAGTTCAAGACTTTCAAGAAAATATGCACACTCTTCTCAACAAAGTAACAGAAGAATACAACAAACTCTTGGTACTTCAAACACG
ACTAAGCAAGATCTGGGGACAGCAGACAGATGGTATGAAACTTGAATTTGGAGAAGAAAACCTTCCAAAAGAGGAAACAGAGTTTTTATC
AATCCATTCTCAGATGACCAATTTGGAAGACATTGATGTCAATCATAAAAGCAAGTTATCTTCTCTGCAAGATCTTGAAAAAACTAAACT
TGAAGAACAAGTTCAAGAATTAGAAAGCCTCATATCCTCTTTGCAGCAACAGTTGAAAGAAACTGAACAAAACTATGAGGCAGAGATCCA
CTGTTTACAGAAGAGGCTTCAAGCTGTTAGTGAGTCCACGGTTCCGCCAAGCTTACCTGTTGATTCGGTGGTAATTACAGAATCTGATGC
ACAGAGAACAATGTACCCTGGAAGTTGTGTGAAAAAGAATATTGATGGTACAATAGAGTTTTCTGGTGAATTTGGAGTGAAAGAGGAAAC
AAATATCGTTAAGTTGCTTGAAAAACAATACCAAGAACAATTAGAAGAAGAAGTAGCTAAGGTTATTGTGTCAATGAGTATAGCATTTGC
TCAACAAACTGAACTGTCTAGAATATCTGGGGGAAAAGAAAATACTGCATCATCAAAGCAAGCACATGCTGTGTGTCAGCAAGAACAACA
TTATTTTAATGAAATGAAATTATCACAGGATCAAATTGGTTTTCAGACTTTTGAGACAGTGGATGTGAAATTTAAAGAAGAATTTAAACC
ACTTAGTAAAGAGTTAGGAGAACATGGAAAGGAAATTTTATTATCAAATAGTGATCCCCATGATATACCAGAATCAAAGGACTGTGTGCT
GACTATTTCAGAAGAAATGTTCTCCAAAGATAAAACATTTATAGTTAGACAGTCTATTCATGATGAGATTTCAGTGTCAAGCATGGATGC
TTCTAGACAACTAATGTTGAATGAAGAACAGTTGGAAGATATGAGACAGGAACTTGTACGACAATACCAAGAACATCAACAGGCAACGGA
ATTGTTAAGGCAAGCACATATGCGGCAAATGGAGAGACAGCGAGAAGACCAGGAACAGCTACAAGAAGAGATTAAGAGACTTAATAGACA
ATTAGCCCAGAGATCCTCCATAGATAATGAAAACCTGGTTTCAGAGAGAGAGAGGGTGCTTTTAGAGGAGCTGGAAGCACTAAAGCAGCT
GTCTTTAGCTGGAAGAGAGAAGCTGTGTTGTGAGCTGCGCAACAGCAGTACGCAAACACAGAATGGAAATGAAAACCAAGGAGAAGTTGA
AGAACAAACATTTAAAGAAAAGGAATTAGACAGAAAACCTGAAGATGTGCCTCCTGAGATTTTGTCTAATGAAAGGTATGCACTCCAGAA
AGCTAATAATAGACTTTTGAAGATCCTCTTAGAAGTTGTAAAGACAACAGCAGCTGTTGAAGAAACAATTGGTCGCCATGTCCTTGGGAT
TCTAGATAGATCTAGTAAAAGCCAGTCATCTGCCAGCCTAATTTGGAGGTCAGAAGCAGAGGCATCTGTAAAGTCATGTGTCCATGAGGA
ACATACAAGAGTTACAGATGAATCCATTCCCTCTTATTCTGGAAGTGATATGCCAAGAAATGACATTAACATGTGGTCAAAAGTAACTGA
GGAAGGAACAGAGCTGTCACAACGACTTGTGAGGAGTGGTTTTGCTGGAACTGAAATAGACCCTGAAAATGAAGAACTTATGCTGAACAT
TAGCTCTCGACTACAAGCAGCAGTTGAAAAACTCCTAGAAGCCATAAGTGAAACTAGCAGTCAGCTTGAACATGCGAAAGTGACACAGAC
AGAGTTGATGCGTGAGTCATTTAGACAGAAACAAGAAGCAACAGAGTCCCTTAAGTGCCAAGAGGAACTTCGAGAGCGCCTTCATGAGGA
GTCCAGGGCCAGAGAACAGCTAGCTGTGGAGCTCAGTAAGGCTGAGGGCGTCATTGATGGCTATGCAGATGAAAAAACTCTTTTTGAAAG
GCAAATTCAGGAAAAAACTGATATAATAGATCGTCTTGAGCAGGAGTTGTTATGTGCAAGTAACAGGTTGCAAGAATTGGAGGCAGAGCA
ACAGCAGATCCAAGAAGAAAGAGAATTACTGTCCAGACAAAAGGAAGCTATGAAAGCAGAGGCAGGCCCAGTTGAACAACAATTACTACA
GGAGACAGAAAAATTAATGAAGGAAAAACTAGAAGTACAATGTCAAGCTGAAAAAGTACGTGATGACCTTCAAAAACAAGTGAAAGCTCT
AGAAATAGATGTGGAAGAACAAGTCAGTAGGTTTATAGAGCTGGAACAAGAAAAAAATACTGAACTAATGGATTTAAGACAGCAAAACCA
AGCATTGGAAAAGCAGTTAGAAAAAATGAGAAAATTTTTAGATGAGCAAGCCATTGACAGAGAACATGAGAGAGATGTATTCCAACAGGA
AATACAGAAACTAGAACAGCAACTTAAGGTTGTTCCTCGATTCCAGCCTATCAGTGAACATCAAACTAGAGAGGTTGAACAGTTAGCAAA
TCATCTGAAAGAAAAAACAGACAAATGCAGTGAGCTTTTGCTCTCTAAAGAGCAGCTTCAAAGGGATATACAAGAAAGGAATGAAGAAAT
AGAGAAACTGGAGTTCAGAGTAAGAGAACTGGAGCAGGCGCTTCTTGTGAGTGCAGATACTTTTCAAAAGGTAGAGGACCGAAAACACTT
TGGAGCTGTAGAAGCTAAACCAGAATTGTCCCTAGAAGTACAATTGCAGGCTGAACGAGATGCCATAGACAGAAAGGAAAAAGAGATTAC
AAACTTAGAAGAGCAATTAGAACAGTTTAGAGAAGAACTGGAAAATAAGAATGAAGAAGTTCAACAATTACATATGCAATTAGAAATACA
GAAAAAGGAATCTACTACCCGCCTACAAGAACTTGAACAGGAAAACAAATTATTTAAGGATGACATGGAGAAACTGGGACTTGCCATAAA
GGAATCTGATGCCATGTCTACTCAAGACCAACATGTGCTATTTGGGAAATTTGCTCAAATAATACAGGAAAAAGAGGTAGAAATTGACCA
ATTAAATGAACAAGTTACGAAACTCCAGCAGCAACTTAAAATTACAACAGATAACAAGGTTATTGAAGAAAAAAATGAACTGATAAGGGA
TCTTGAAACCCAAATAGAATGTTTGATGAGTGATCAAGAATGTGTGAAGAGAAATAGAGAAGAAGAAATAGAGCAGCTCAATGAAGTGAT
TGAAAAACTTCAACAGGAATTGGCAAATATTGGACAGAAGACATCAATGAATGCTCATTCCCTCTCAGAAGAAGCAGACAGTTTAAAACA
TCAATTGGATGTGGTTATAGCTGAAAAGCTGGCCTTGGAACAGCAAGTAGAAACCGCTAATGAAGAAATGACCTTCATGAAAAATGTACT
TAAAGAAACCAATTTTAAAATGAATCAGCTAACACAGGAATTATTCAGCTTAAAGAGAGAACGTGAAAGTGTGGAAAAGATTCAAAGCAT
ACCAGAGAATAGTGTTAACGTGGCTATAGATCATCTGAGCAAAGACAAACCTGAACTAGAAGTAGTCCTTACAGAGGATGCTCTTAAATC
CCTAGAAAATCAGACATACTTCAAATCTTTTGAAGAAAATGGCAAAGGTTCCATAATTAATTTGGAAACAAGGTTGCTACAACTTGAGAG
CACTGTTAGTGCAAAGGACTTAGAACTTACCCAGTGTTATAAACAAATAAAAGACATGCAAGAACAAGGCCAGTTTGAAACAGAAATGCT
TCAAAAGAAGATTGTAAACCTACAGAAAATAGTTGAAGAAAAAGTGGCTGCTGCTCTTGTCAGTCAAATCCAACTTGAGGCAGTTCAGGA
ATATGCAAAATTCTGTCAAGATAATCAAACAATTTCATCAGAACCTGAAAGAACAAATATTCAGAATTTAAATCAACTAAGAGAAGATGA
GTTGGGGTCAGATATATCAGCATTAACCTTGAGAATATCAGAATTAGAAAGCCAGGTTGTTGAAATGCATACTAGTTTGATTTTAGAAAA
AGAACAAGTAGAAATTGCAGAAAAAAATGTTTTAGAAAAAGAAAAGAAGCTGCTAGAACTACAGAAGCTATTGGAGGGCAATGAGAAAAA
ACAGAGAGAGAAAGAAAAGAAAAGAAGCCCTCAAGATGTTGAAGTTCTCAAGACAACTACTGAGCTATTTCATAGCAATGAAGAAAGTGG
ATTTTTTAATGAACTCGAGGCTCTTAGAGCTGAATCAGTGGCTACCAAAGCAGAACTTGCCAGTTATAAAGAAAAGGCTGAAAAACTTCA
AGAAGAGCTTTTGGTAAAAGAAACAAATATGACATCTCTTCAGAAAGACTTAAGCCAAGTTAGGGATCACCTCGCAGAGGCAAAAGAGAA
ATTGTCCATTTTAGAAAAAGAAGATGAGACTGAGGTACAAGAAAGCAAAAAGGCCTGCATGTTTGAGCCACTTCCTATAAAACTGAGTAA
GAGCATTGCATCCCAGACAGATGGGACTCTGAAGATCAGTAGCAGCAATCAGACTCCACAAATTCTTGTTAAAAATGCAGGAATACAAAT
TAATTTACAGAGTGAATGTTCCTCAGAAGAAGTTACTGAAATAATCAGTCAGTTTACTGAAAAAATTGAGAAGATGCAAGAACTACATGC
TGCTGAAATTTTGGACATGGAATCCAGACATATTTCAGAAACTGAAACCTTAAAGAGGGAACACTATGTTGCCGTTCAGTTACTGAAAGA
GGAATGTGGTACCTTGAAGGCAGTGATACAGTGTCTGAGAAGTAAAGAGGGATCCTCAATTCCTGAGCTAGCACATTCTGATGCTTACCA
GACTAGAGAAATATGCTCCAGTGATTCTGGATCAGACTGGGGTCAGGGAATTTATCTTACACACAGTCAGGGATTTGACATAGCATCAGA
AGGCCGAGGAGAAGAAAGTGAAAGTGCAACAGATTCCTTTCCAAAGAAAATAAAGGGATTACTGAGAGCTGTCCATAATGAAGGCATGCA
GGTGCTTTCTCTCACTGAGTCTCCCTATAGTGATGGAGAGGACCATTCTATTCAGCAGGTTTCAGAACCTTGGCTAGAAGAGAGAAAAGC
TTACATCAATACAATCTCATCTCTAAAGGATTTAATTACAAAGATGCAACTGCAAAGAGAAGCCGAGGTTTATGATAGTTCTCAATCTCA
TGAGAGCTTCTCAGACTGGCGAGGTGAACTACTGCTTGCCCTTCAACAAGTTTTCTTAGAAGAGCGTAGTGTTTTACTAGCAGCATTTCG
GACGGAGCTGACAGCTCTAGGTACTACAGATGCAGTTGGTTTACTAAACTGTTTGGAACAGAGAATACAAGAACAGGGTGTTGAATATCA
AGCAGCTATGGAATGCCTCCAGAAAGCAGATAGAAGGAGTTTGTTATCTGAAATTCAGGCACTGCATGCACAAATGAATGGTAGGAAAAT
TACTCTGAAAAGAGAACAAGAGAGTGAGAAACCAAGCCAAGAACTCTTGGAATATAATATACAGCAGAAGCAGTCTCAAATGCTGGAGAT
GCAAGTGGAGCTCAGCAGTATGAAAGACAGAGCAACGGAACTGCAGGAGCAGCTGAGTTCTGAGAAAATGGTGGTTGCTGAACTGAAGAG
TGAGCTTGCACAAACTAAATTGGAACTAGAAACAACACTCAAGGCACAGCATAAACACCTAAAAGAATTGGAGGCTTTCAGGTTGGAAGT
TAAAGATAAGACAGATGAAGTACATTTGCTTAATGACACATTAGCAAGTGAACAGAAAAAATCAAGAGAGCTCCAGTGGGCTTTGGAGAA
AGAGAAAGCCAAGTTGGGACGCAGTGAAGAACGGGATAAAGAAGAACTTGAGGATCTGAAGTTTTCACTTGAGAGTCAGAAACAAAGGAA
TCTTCAGCTAAATCTACTTTTGGAACAACAGAAACAACTACTGAACGAATCCCAGCAAAAAATAGAATCACAGAGAATGCTATATGATGC
CCAGTTGTCAGAAGAACAAGGTCGAAACTTAGAGCTTCAGGTACTTCTTGAATCTGAGAAAGTTCGAATTCGGGAAATGAGTAGTACCCT
AGATAGGGAGCGGGAATTGCACGCACAGCTGCAGAGCAGTGATGGTACTGGACAGTCTCGGCCACCCTTGCCCTCAGAGGACCTACTGAA
AGAGCTGCAGAAACAGCTAGAGGAAAAACACAGTCGCATAGTAGAATTGTTAAATGAGACTGAAAAATATAAACTGGATTCTTTGCAAAC
ACGACAGCAAATGGAAAAAGATAGGCAGGTTCACAGGAAAACACTGCAGACAGAACAGGAGGCCAACACTGAGGGACAGAAAAAAATGCA
TGAGCTCCAGTCCAAAGTGGAAGATCTTCAGCGCCAGCTGGAAGAGAAAAGACAACAAGTTTATAAGTTAGACCTTGAAGGACAGCGACT
ACAAGGAATCATGCAGGAATTCCAGAAGCAAGAACTAGAACGAGAAGAAAAACGAGAAAGTAGAAGAATTCTGTATCAGAACCTTAATGA
GCCAACCACGTGGAGCTTAACCAGTGATAGAACTAGAAATTGGGTTCTTCAACAGAAAATAGAAGGAGAAACAAAAGAATCAAACTACGC
TAAATTGATTGAAATGAATGGAGGAGGAACCGGCTGTAATCATGAATTAGAAATGATCAGACAAAAGCTTCAATGTGTAGCTTCAAAACT
ACAGGTTCTACCCCAGAAAGCCTCTGAGAGACTACAGTTTGAAACAGCAGATGATGAAGATTTCATTTGGGTTCAGGAAAATATTGATGA
AATTATTTTACAACTACAGAAATTAACTGGCCAGCAAGGTGAAGAGCCCAGCTTGGTGTCCCCAAGTACTTCTTGTGGCTCATTGACTGA
AAGACTACTGAGACAAAATGCTGAGCTGACAGGGCATATCAGTCAACTGACTGAAGAGAAGAATGACTTAAGGAACATGGTTATGAAGCT
GGAAGAGCAGATCAGGTGGTATCGACAGACAGGAGCTGGTAGAGATAATTCTTCCAGGTTTTCATTGAATGGTGGTGCCAACATTGAAGC
CATCATTGCCTCTGAAAAAGAAGTATGGAACAGAGAAAAATTGACTCTCCAGAAATCTTTGAAAAGGGCAGAGGCTGAAGTATACAAACT
GAAAGCTGAACTAAGAAATGACTCTTTACTTCAAACTCTGAGCCCTGATTCTGAACATGTCACTTTAAAGAGAATTTATGGTAAATACTT
GAGGGCAGAAAGTTTTCGAAAGGCTCTCATTTACCAGAAGAAATACCTGCTGCTGTTACTGGGTGGGTTCCAGGAATGTGAAGATGCCAC
CTTGGCCCTGCTTGCCCGGATGGGGGGGCAGCCAGCTTTCACGGATCTAGAGGTGATCACCAATCGCCCAAAGGGCTTCACCAGGTTTCG
GTCGGCCGTCAGAGTATCCATTGCAATTTCCAGAATGAAATTTTTGGTTCGACGGTGGCATCGAGTCACAGGTTCTGTTTCCATCAATAT
TAACAGAGATGGCTTTGGACTGAATCAAGGTGCAGAAAAGACTGACTCATTTTATCATTCTTCTGGTGGGCTGGAGTTATATGGAGAACC
AAGACATACTACGTATCGCTCAAGATCAGATCTGGACTATATTAGGTCCCCTTTACCATTTCAGAATAGGTACCCAGGCACTCCAGCTGA
TTTCAATCCTGGTTCTTTAGCATGTTCTCAGCTTCAGAATTACGATCCTGACAGAGCCCTAACAGATTATATCACTCGGCTAGAGGCACT
GCAAAGACGACTTGGAACTATACAGTCAGGTTCAACTACTCAATTTCATGCTGGCATGAGAAGATAATCCTTTGAAACATCATTAATTGA
AGTGATTTTAAATAGATTTCCTTTTGTAAATCAATGGTTCTTTTGTGCTTTTGTATTGTGAATATTCAATGGGACCAATATGAACACAGC
TTATGATTGTATACAAATCCCTTGCCAGCACATGAAAACAAACTGGAATTTGTATATATAAGCATTGTGTATGTATTCATGCACAATAAT
TATTGAATTACCTGTATATTTGTGGAATGCTAATTTAAAACATTAAATTATAAACCTTGTGTATTTATCAAATGGGTGAAAAGATTAAAC
TTTTACGCATTACAATACTGCTGAATGTGTAGCTCGAGGTGTCCTGCACTTTTCTTATAAGGCTACTGAAGTTACATGTTTTGCCTAATA
TATTCTACTGGTGATGAAGACAGATAATATCACTTGTAGAGACCTATTTTTGTATAATGGTAGAAGTTTTGAATTTTATGGGGTATTTTG

>10112_10112_1_BRAF-AKAP9_BRAF_chr7_140494107_ENST00000288602_AKAP9_chr7_91641742_ENST00000356239_length(amino acids)=3181AA_BP=380
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLD
ALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQ
RCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQE
TGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEE
YNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKE
TEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAK
VIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPH
DIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQL
QEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEI
LSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRN
DINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQ
EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAE
AGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDR
EHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADT
FQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKD
DMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNRE
EEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRE
RESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQ
EQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVV
EMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELA
SYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQ
ILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSI
PELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQV
SEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQ
RIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSS
EKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLK
FSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSR
PPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQV
YKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIR
QKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEK
NDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHV
TLKRIYGKYLRAESFRKALIYQKKYLLLLLGGFQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKFLVRRWH
RVTGSVSININRDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYIRSPLPFQNRYPGTPADFNPGSLACSQLQNYDPDRAL

--------------------------------------------------------------
>10112_10112_2_BRAF-AKAP9_BRAF_chr7_140494107_ENST00000288602_AKAP9_chr7_91641742_ENST00000358100_length(transcript)=9935nt_BP=1201nt
CGCCTCCCTTCCCCCTCCCCGCCCGACAGCGGCCGCTCGGGCCCCGGCTCTCGGTTATAAGATGGCGGCGCTGAGCGGTGGCGGTGGTGG
CGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGCGCCGGCGCCGCGGCCTCTTCGGCTGCGGA
CCCTGCCATTCCGGAGGAGGTGTGGAATATCAAACAAATGATTAAGTTGACACAGGAACATATAGAGGCCCTATTGGACAAATTTGGTGG
GGAGCATAATCCACCATCAATATATCTGGAGGCCTATGAAGAATACACCAGCAAGCTAGATGCACTCCAACAAAGAGAACAACAGTTATT
GGAATCTCTGGGGAACGGAACTGATTTTTCTGTTTCTAGCTCTGCATCAATGGATACCGTTACATCTTCTTCCTCTTCTAGCCTTTCAGT
GCTACCTTCATCTCTTTCAGTTTTTCAAAATCCCACAGATGTGGCACGGAGCAACCCCAAGTCACCACAAAAACCTATCGTTAGAGTCTT
CCTGCCCAACAAACAGAGGACAGTGGTACCTGCAAGGTGTGGAGTTACAGTCCGAGACAGTCTAAAGAAAGCACTGATGATGAGAGGTCT
AATCCCAGAGTGCTGTGCTGTTTACAGAATTCAGGATGGAGAGAAGAAACCAATTGGTTGGGACACTGATATTTCCTGGCTTACTGGAGA
AGAATTGCATGTGGAAGTGTTGGAGAATGTTCCACTTACAACACACAACTTTGTACGAAAAACGTTTTTCACCTTAGCATTTTGTGACTT
TTGTCGAAAGCTGCTTTTCCAGGGTTTCCGCTGTCAAACATGTGGTTATAAATTTCACCAGCGTTGTAGTACAGAAGTTCCACTGATGTG
TGTTAATTATGACCAACTTGATTTGCTGTTTGTCTCCAAGTTCTTTGAACACCACCCAATACCACAGGAAGAGGCGTCCTTAGCAGAGAC
TGCCCTAACATCTGGATCATCCCCTTCCGCACCCGCCTCGGACTCTATTGGGCCCCAAATTCTCACCAGTCCGTCTCCTTCAAAATCCAT
TCCAATTCCACAGCCCTTCCGACCAGCAGATGAAGATCATCGAAATCAATTTGGGCAACGAGACCGATCCTCATCAGCTCCCAATGTGCA
TATAAACACAATAGAACCTGTCAATATTGATAATGATTTAAGGCTACAGATGGAAGCCCAACGCATTTGCCTCTCTCTGGTTTATTCAAC
TCATGTGGATCAGGTTCGTGAATATATGGAAAATGAAAAAGATAAAGCTCTTTGCAGTCTTAAAGAAGAGCTTATTTTTGCTCAAGAGGA
AAAGATCAAGGAACTTCAGAAAATACACCAGTTAGAACTACAGACTATGAAAACACAAGAAACAGGTGATGAAGGAAAGCCTTTACATCT
GCTCATTGGAAAACTTCAAAAGGCAGTGTCTGAAGAATGTTCTTATTTTTTACAGACTTTATGCAGTGTCCTTGGTGAATATTATACTCC
TGCTTTAAAATGTGAAGTAAATGCAGAAGACAAAGAGAATTCTGGTGATTACATTTCTGAAAATGAAGATCCAGAATTACAAGATTATAG
ATATGAAGTTCAAGACTTTCAAGAAAATATGCACACTCTTCTCAACAAAGTAACAGAAGAATACAACAAACTCTTGGTACTTCAAACACG
ACTAAGCAAGATCTGGGGACAGCAGACAGATGGTATGAAACTTGAATTTGGAGAAGAAAACCTTCCAAAAGAGGAAACAGAGTTTTTATC
AATCCATTCTCAGATGACCAATTTGGAAGACATTGATGTCAATCATAAAAGCAAGTTATCTTCTCTGCAAGATCTTGAAAAAACTAAACT
TGAAGAACAAGTTCAAGAATTAGAAAGCCTCATATCCTCTTTGCAGCAACAGTTGAAAGAAACTGAACAAAACTATGAGGCAGAGATCCA
CTGTTTACAGAAGAGGCTTCAAGCTGTTAGTGAGTCCACGGTTCCGCCAAGCTTACCTGTTGATTCGGTGGTAATTACAGAATCTGATGC
ACAGAGAACAATGTACCCTGGAAGTTGTGTGAAAAAGAATATTGATGGTACAATAGAGTTTTCTGGTGAATTTGGAGTGAAAGAGGAAAC
AAATATCGTTAAGTTGCTTGAAAAACAATACCAAGAACAATTAGAAGAAGAAGTAGCTAAGGTTATTGTGTCAATGAGTATAGCATTTGC
TCAACAAACTGAACTGTCTAGAATATCTGGGGGAAAAGAAAATACTGCATCATCAAAGCAAGCACATGCTGTGTGTCAGCAAGAACAACA
TTATTTTAATGAAATGAAATTATCACAGGATCAAATTGGTTTTCAGACTTTTGAGACAGTGGATGTGAAATTTAAAGAAGAATTTAAACC
ACTTAGTAAAGAGTTAGGAGAACATGGAAAGGAAATTTTATTATCAAATAGTGATCCCCATGATATACCAGAATCAAAGGACTGTGTGCT
GACTATTTCAGAAGAAATGTTCTCCAAAGATAAAACATTTATAGTTAGACAGTCTATTCATGATGAGATTTCAGTGTCAAGCATGGATGC
TTCTAGACAACTAATGTTGAATGAAGAACAGTTGGAAGATATGAGACAGGAACTTGTACGACAATACCAAGAACATCAACAGGCAACGGA
ATTGTTAAGGCAAGCACATATGCGGCAAATGGAGAGACAGCGAGAAGACCAGGAACAGCTACAAGAAGAGATTAAGAGACTTAATAGACA
ATTAGCCCAGAGATCCTCCATAGATAATGAAAACCTGGTTTCAGAGAGAGAGAGGGTGCTTTTAGAGGAGCTGGAAGCACTAAAGCAGCT
GTCTTTAGCTGGAAGAGAGAAGCTGTGTTGTGAGCTGCGCAACAGCAGTACGCAAACACAGAATGGAAATGAAAACCAAGGAGAAGTTGA
AGAACAAACATTTAAAGAAAAGGAATTAGACAGAAAACCTGAAGATGTGCCTCCTGAGATTTTGTCTAATGAAAGGTATGCACTCCAGAA
AGCTAATAATAGACTTTTGAAGATCCTCTTAGAAGTTGTAAAGACAACAGCAGCTGTTGAAGAAACAATTGGTCGCCATGTCCTTGGGAT
TCTAGATAGATCTAGTAAAAGCCAGTCATCTGCCAGCCTAATTTGGAGGTCAGAAGCAGAGGCATCTGTAAAGTCATGTGTCCATGAGGA
ACATACAAGAGTTACAGATGAATCCATTCCCTCTTATTCTGGAAGTGATATGCCAAGAAATGACATTAACATGTGGTCAAAAGTAACTGA
GGAAGGAACAGAGCTGTCACAACGACTTGTGAGGAGTGGTTTTGCTGGAACTGAAATAGACCCTGAAAATGAAGAACTTATGCTGAACAT
TAGCTCTCGACTACAAGCAGCAGTTGAAAAACTCCTAGAAGCCATAAGTGAAACTAGCAGTCAGCTTGAACATGCGAAAGTGACACAGAC
AGAGTTGATGCGTGAGTCATTTAGACAGAAACAAGAAGCAACAGAGTCCCTTAAGTGCCAAGAGGAACTTCGAGAGCGCCTTCATGAGGA
GTCCAGGGCCAGAGAACAGCTAGCTGTGGAGCTCAGTAAGGCTGAGGGCGTCATTGATGGCTATGCAGATGAAAAAACTCTTTTTGAAAG
GCAAATTCAGGAAAAAACTGATATAATAGATCGTCTTGAGCAGGAGTTGTTATGTGCAAGTAACAGGTTGCAAGAATTGGAGGCAGAGCA
ACAGCAGATCCAAGAAGAAAGAGAATTACTGTCCAGACAAAAGGAAGCTATGAAAGCAGAGGCAGGCCCAGTTGAACAACAATTACTACA
GGAGACAGAAAAATTAATGAAGGAAAAACTAGAAGTACAATGTCAAGCTGAAAAAGTACGTGATGACCTTCAAAAACAAGTGAAAGCTCT
AGAAATAGATGTGGAAGAACAAGTCAGTAGGTTTATAGAGCTGGAACAAGAAAAAAATACTGAACTAATGGATTTAAGACAGCAAAACCA
AGCATTGGAAAAGCAGTTAGAAAAAATGAGAAAATTTTTAGATGAGCAAGCCATTGACAGAGAACATGAGAGAGATGTATTCCAACAGGA
AATACAGAAACTAGAACAGCAACTTAAGGTTGTTCCTCGATTCCAGCCTATCAGTGAACATCAAACTAGAGAGGTTGAACAGTTAGCAAA
TCATCTGAAAGAAAAAACAGACAAATGCAGTGAGCTTTTGCTCTCTAAAGAGCAGCTTCAAAGGGATATACAAGAAAGGAATGAAGAAAT
AGAGAAACTGGAGTTCAGAGTAAGAGAACTGGAGCAGGCGCTTCTTGTGAGTGCAGATACTTTTCAAAAGGTAGAGGACCGAAAACACTT
TGGAGCTGTAGAAGCTAAACCAGAATTGTCCCTAGAAGTACAATTGCAGGCTGAACGAGATGCCATAGACAGAAAGGAAAAAGAGATTAC
AAACTTAGAAGAGCAATTAGAACAGTTTAGAGAAGAACTGGAAAATAAGAATGAAGAAGTTCAACAATTACATATGCAATTAGAAATACA
GAAAAAGGAATCTACTACCCGCCTACAAGAACTTGAACAGGAAAACAAATTATTTAAGGATGACATGGAGAAACTGGGACTTGCCATAAA
GGAATCTGATGCCATGTCTACTCAAGACCAACATGTGCTATTTGGGAAATTTGCTCAAATAATACAGGAAAAAGAGGTAGAAATTGACCA
ATTAAATGAACAAGTTACGAAACTCCAGCAGCAACTTAAAATTACAACAGATAACAAGGTTATTGAAGAAAAAAATGAACTGATAAGGGA
TCTTGAAACCCAAATAGAATGTTTGATGAGTGATCAAGAATGTGTGAAGAGAAATAGAGAAGAAGAAATAGAGCAGCTCAATGAAGTGAT
TGAAAAACTTCAACAGGAATTGGCAAATATTGGACAGAAGACATCAATGAATGCTCATTCCCTCTCAGAAGAAGCAGACAGTTTAAAACA
TCAATTGGATGTGGTTATAGCTGAAAAGCTGGCCTTGGAACAGCAAGTAGAAACCGCTAATGAAGAAATGACCTTCATGAAAAATGTACT
TAAAGAAACCAATTTTAAAATGAATCAGCTAACACAGGAATTATTCAGCTTAAAGAGAGAACGTGAAAGTGTGGAAAAGATTCAAAGCAT
ACCAGAGAATAGTGTTAACGTGGCTATAGATCATCTGAGCAAAGACAAACCTGAACTAGAAGTAGTCCTTACAGAGGATGCTCTTAAATC
CCTAGAAAATCAGACATACTTCAAATCTTTTGAAGAAAATGGCAAAGGTTCCATAATTAATTTGGAAACAAGGTTGCTACAACTTGAGAG
CACTGTTAGTGCAAAGGACTTAGAACTTACCCAGTGTTATAAACAAATAAAAGACATGCAAGAACAAGGCCAGTTTGAAACAGAAATGCT
TCAAAAGAAGATTGTAAACCTACAGAAAATAGTTGAAGAAAAAGTGGCTGCTGCTCTTGTCAGTCAAATCCAACTTGAGGCAGTTCAGGA
ATATGCAAAATTCTGTCAAGATAATCAAACAATTTCATCAGAACCTGAAAGAACAAATATTCAGAATTTAAATCAACTAAGAGAAGATGA
GTTGGGGTCAGATATATCAGCATTAACCTTGAGAATATCAGAATTAGAAAGCCAGGTTGTTGAAATGCATACTAGTTTGATTTTAGAAAA
AGAACAAGTAGAAATTGCAGAAAAAAATGTTTTAGAAAAAGAAAAGAAGCTGCTAGAACTACAGAAGCTATTGGAGGGCAATGAGAAAAA
ACAGAGAGAGAAAGAAAAGAAAAGAAGCCCTCAAGATGTTGAAGTTCTCAAGACAACTACTGAGCTATTTCATAGCAATGAAGAAAGTGG
ATTTTTTAATGAACTCGAGGCTCTTAGAGCTGAATCAGTGGCTACCAAAGCAGAACTTGCCAGTTATAAAGAAAAGGCTGAAAAACTTCA
AGAAGAGCTTTTGGTAAAAGAAACAAATATGACATCTCTTCAGAAAGACTTAAGCCAAGTTAGGGATCACCTCGCAGAGGCAAAAGAGAA
ATTGTCCATTTTAGAAAAAGAAGATGAGACTGAGGTACAAGAAAGCAAAAAGGCCTGCATGTTTGAGCCACTTCCTATAAAACTGAGTAA
GAGCATTGCATCCCAGACAGATGGGACTCTGAAGATCAGTAGCAGCAATCAGACTCCACAAATTCTTGTTAAAAATGCAGGAATACAAAT
TAATTTACAGAGTGAATGTTCCTCAGAAGAAGTTACTGAAATAATCAGTCAGTTTACTGAAAAAATTGAGAAGATGCAAGAACTACATGC
TGCTGAAATTTTGGACATGGAATCCAGACATATTTCAGAAACTGAAACCTTAAAGAGGGAACACTATGTTGCCGTTCAGTTACTGAAAGA
GGAATGTGGTACCTTGAAGGCAGTGATACAGTGTCTGAGAAGTAAAGAGGGATTACTGAGAGCTGTCCATAATGAAGGCATGCAGGTGCT
TTCTCTCACTGAGTCTCCCTATAGTGATGGAGAGGACCATTCTATTCAGCAGGTTTCAGAACCTTGGCTAGAAGAGAGAAAAGCTTACAT
CAATACAATCTCATCTCTAAAGGATTTAATTACAAAGATGCAACTGCAAAGAGAAGCCGAGGTTTATGATAGTTCTCAATCTCATGAGAG
CTTCTCAGACTGGCGAGGTGAACTACTGCTTGCCCTTCAACAAGTTTTCTTAGAAGAGCGTAGTGTTTTACTAGCAGCATTTCGGACGGA
GCTGACAGCTCTAGGTACTACAGATGCAGTTGGTTTACTAAACTGTTTGGAACAGAGAATACAAGAACAGGGTGTTGAATATCAAGCAGC
TATGGAATGCCTCCAGAAAGCAGATAGAAGGAGTTTGTTATCTGAAATTCAGGCACTGCATGCACAAATGAATGGTAGGAAAATTACTCT
GAAAAGAGAACAAGAGAGTGAGAAACCAAGCCAAGAACTCTTGGAATATAATATACAGCAGAAGCAGTCTCAAATGCTGGAGATGCAAGT
GGAGCTCAGCAGTATGAAAGACAGAGCAACGGAACTGCAGGAGCAGCTGAGTTCTGAGAAAATGGTGGTTGCTGAACTGAAGAGTGAGCT
TGCACAAACTAAATTGGAACTAGAAACAACACTCAAGGCACAGCATAAACACCTAAAAGAATTGGAGGCTTTCAGGTTGGAAGTTAAAGA
TAAGACAGATGAAGTACATTTGCTTAATGACACATTAGCAAGTGAACAGAAAAAATCAAGAGAGCTCCAGTGGGCTTTGGAGAAAGAGAA
AGCCAAGTTGGGACGCAGTGAAGAACGGGATAAAGAAGAACTTGAGGATCTGAAGTTTTCACTTGAGAGTCAGAAACAAAGGAATCTTCA
GCTAAATCTACTTTTGGAACAACAGAAACAACTACTGAACGAATCCCAGCAAAAAATAGAATCACAGAGAATGCTATATGATGCCCAGTT
GTCAGAAGAACAAGGTCGAAACTTAGAGCTTCAGGTACTTCTTGAATCTGAGAAAGTTCGAATTCGGGAAATGAGTAGTACCCTAGATAG
GGAGCGGGAATTGCACGCACAGCTGCAGAGCAGTGATGGTACTGGACAGTCTCGGCCACCCTTGCCCTCAGAGGACCTACTGAAAGAGCT
GCAGAAACAGCTAGAGGAAAAACACAGTCGCATAGTAGAATTGTTAAATGAGACTGAAAAATATAAACTGGATTCTTTGCAAACACGACA
GCAAATGGAAAAAGATAGGCAGGTTCACAGGAAAACACTGCAGACAGAACAGGAGGCCAACACTGAGGGACAGAAAAAAATGCATGAGCT
CCAGTCCAAAGTGGAAGATCTTCAGCGCCAGCTGGAAGAGAAAAGACAACAAGTTTATAAGTTAGACCTTGAAGGACAGCGACTACAAGG
AATCATGCAGGAATTCCAGAAGCAAGAACTAGAACGAGAAGAAAAACGAGAAAGTAGAAGAATTCTGTATCAGAACCTTAATGAGCCAAC
CACGTGGAGCTTAACCAGTGATAGAACTAGAAATTGGGTTCTTCAACAGAAAATAGAAGGAGAAACAAAAGAATCAAACTACGCTAAATT
GATTGAAATGAATGGAGGAGGAACCGGCTGTAATCATGAATTAGAAATGATCAGACAAAAGCTTCAATGTGTAGCTTCAAAACTACAGGT
TCTACCCCAGAAAGCCTCTGAGAGACTACAGTTTGAAACAGCAGATGATGAAGATTTCATTTGGGTTCAGGAAAATATTGATGAAATTAT
TTTACAACTACAGAAATTAACTGGCCAGCAAGGTGAAGAGCCCAGCTTGGTGTCCCCAAGTACTTCTTGTGGCTCATTGACTGAAAGACT
ACTGAGACAAAATGCTGAGCTGACAGGGCATATCAGTCAACTGACTGAAGAGAAGAATGACTTAAGGAACATGGTTATGAAGCTGGAAGA
GCAGATCAGGTGGTATCGACAGACAGGAGCTGGTAGAGATAATTCTTCCAGGTTTTCATTGAATGGTGGTGCCAACATTGAAGCCATCAT
TGCCTCTGAAAAAGAAGTATGGAACAGAGAAAAATTGACTCTCCAGAAATCTTTGAAAAGGGCAGAGGCTGAAGTATACAAACTGAAAGC
TGAACTAAGAAATGACTCTTTACTTCAAACTCTGAGCCCTGATTCTGAACATGTCACTTTAAAGAGAATTTATGGTAAATACTTGAGGGC
AGAAAGTTTTCGAAAGGCTCTCATTTACCAGAAGAAATACCTGCTGCTGTTACTGGGTGGGTTCCAGGAATGTGAAGATGCCACCTTGGC
CCTGCTTGCCCGGATGGGGGGGCAGCCAGCTTTCACGGATCTAGAGGTGATCACCAATCGCCCAAAGGGCTTCACCAGGTTTCGGTCGGC
CGTCAGAGTATCCATTGCAATTTCCAGAATGAAATTTTTGGTTCGACGGTGGCATCGAGTCACAGGTTCTGTTTCCATCAATATTAACAG
AGATGGCTTTGGACTGAATCAAGGTGCAGAAAAGACTGACTCATTTTATCATTCTTCTGGTGGGCTGGAGTTATATGGAGAACCAAGACA
TACTACGTATCGCTCAAGATCAGATCTGGACTATATTAGGTCCCCTTTACCATTTCAGAATAGGTACCCAGGCACTCCAGCTGATTTCAA
TCCTGGTTCTTTAGCATGTTCTCAGCTTCAGAATTACGATCCTGACAGAGCCCTAACAGATTATATCACTCGGCTAGAGGCACTGCAAAG
ACGACTTGGAACTATACAGTCAGGTTCAACTACTCAATTTCATGCTGGCATGAGAAGATAATCCTTTGAAACATCATTAATTGAAGTGAT
TTTAAATAGATTTCCTTTTGTAAATCAATGGTTCTTTTGTGCTTTTGTATTGTGAATATTCAATGGGACCAATATGAACACAGCTTATGA
TTGTATACAAATCCCTTGCCAGCACATGAAAACAAACTGGAATTTGTATATATAAGCATTGTGTATGTATTCATGCACAATAATTATTGA
ATTACCTGTATATTTGTGGAATGCTAATTTAAAACATTAAATTATAAACCTTGTGTATTTATCAAATGGGTGAAAAGATTAAACTTTTAC
GCATTACAATACTGCTGAATGTGTAGCTCGAGGTGTCCTGCACTTTTCTTATAAGGCTACTGAAGTTACATGTTTTGCCTAATATATTCT
ACTGGTGATGAAGACAGATAATATCACTTGTAGAGACCTATTTTTGTATAATGGTAGAAGTTTTGAATTTTATGGGGTATTTTGTCAAGT

>10112_10112_2_BRAF-AKAP9_BRAF_chr7_140494107_ENST00000288602_AKAP9_chr7_91641742_ENST00000358100_length(amino acids)=3119AA_BP=380
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLD
ALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQ
RCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQE
TGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEE
YNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKE
TEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAK
VIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPH
DIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQL
QEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEI
LSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRN
DINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQ
EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAE
AGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDR
EHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADT
FQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKD
DMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNRE
EEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRE
RESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQ
EQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVV
EMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELA
SYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQ
ILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGLLR
AVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEER
SVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQ
KQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSR
ELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVR
IREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEAN
TEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEG
ETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPS
TSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKR
AEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKKYLLLLLGGFQECEDATLALLARMGGQPAFTDLEVITNR
PKGFTRFRSAVRVSIAISRMKFLVRRWHRVTGSVSININRDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYIRSPLPFQN

--------------------------------------------------------------
>10112_10112_3_BRAF-AKAP9_BRAF_chr7_140494107_ENST00000288602_AKAP9_chr7_91641742_ENST00000359028_length(transcript)=10097nt_BP=1201nt
CGCCTCCCTTCCCCCTCCCCGCCCGACAGCGGCCGCTCGGGCCCCGGCTCTCGGTTATAAGATGGCGGCGCTGAGCGGTGGCGGTGGTGG
CGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGCGCCGGCGCCGCGGCCTCTTCGGCTGCGGA
CCCTGCCATTCCGGAGGAGGTGTGGAATATCAAACAAATGATTAAGTTGACACAGGAACATATAGAGGCCCTATTGGACAAATTTGGTGG
GGAGCATAATCCACCATCAATATATCTGGAGGCCTATGAAGAATACACCAGCAAGCTAGATGCACTCCAACAAAGAGAACAACAGTTATT
GGAATCTCTGGGGAACGGAACTGATTTTTCTGTTTCTAGCTCTGCATCAATGGATACCGTTACATCTTCTTCCTCTTCTAGCCTTTCAGT
GCTACCTTCATCTCTTTCAGTTTTTCAAAATCCCACAGATGTGGCACGGAGCAACCCCAAGTCACCACAAAAACCTATCGTTAGAGTCTT
CCTGCCCAACAAACAGAGGACAGTGGTACCTGCAAGGTGTGGAGTTACAGTCCGAGACAGTCTAAAGAAAGCACTGATGATGAGAGGTCT
AATCCCAGAGTGCTGTGCTGTTTACAGAATTCAGGATGGAGAGAAGAAACCAATTGGTTGGGACACTGATATTTCCTGGCTTACTGGAGA
AGAATTGCATGTGGAAGTGTTGGAGAATGTTCCACTTACAACACACAACTTTGTACGAAAAACGTTTTTCACCTTAGCATTTTGTGACTT
TTGTCGAAAGCTGCTTTTCCAGGGTTTCCGCTGTCAAACATGTGGTTATAAATTTCACCAGCGTTGTAGTACAGAAGTTCCACTGATGTG
TGTTAATTATGACCAACTTGATTTGCTGTTTGTCTCCAAGTTCTTTGAACACCACCCAATACCACAGGAAGAGGCGTCCTTAGCAGAGAC
TGCCCTAACATCTGGATCATCCCCTTCCGCACCCGCCTCGGACTCTATTGGGCCCCAAATTCTCACCAGTCCGTCTCCTTCAAAATCCAT
TCCAATTCCACAGCCCTTCCGACCAGCAGATGAAGATCATCGAAATCAATTTGGGCAACGAGACCGATCCTCATCAGCTCCCAATGTGCA
TATAAACACAATAGAACCTGTCAATATTGATAATGATTTAAGGCTACAGATGGAAGCCCAACGCATTTGCCTCTCTCTGGTTTATTCAAC
TCATGTGGATCAGGTTCGTGAATATATGGAAAATGAAAAAGATAAAGCTCTTTGCAGTCTTAAAGAAGAGCTTATTTTTGCTCAAGAGGA
AAAGATCAAGGAACTTCAGAAAATACACCAGTTAGAACTACAGACTATGAAAACACAAGAAACAGGTGATGAAGGAAAGCCTTTACATCT
GCTCATTGGAAAACTTCAAAAGGCAGTGTCTGAAGAATGTTCTTATTTTTTACAGACTTTATGCAGTGTCCTTGGTGAATATTATACTCC
TGCTTTAAAATGTGAAGTAAATGCAGAAGACAAAGAGAATTCTGGTGATTACATTTCTGAAAATGAAGATCCAGAATTACAAGATTATAG
ATATGAAGTTCAAGACTTTCAAGAAAATATGCACACTCTTCTCAACAAAGTAACAGAAGAATACAACAAACTCTTGGTACTTCAAACACG
ACTAAGCAAGATCTGGGGACAGCAGACAGATGGTATGAAACTTGAATTTGGAGAAGAAAACCTTCCAAAAGAGGAAACAGAGTTTTTATC
AATCCATTCTCAGATGACCAATTTGGAAGACATTGATGTCAATCATAAAAGCAAGTTATCTTCTCTGCAAGATCTTGAAAAAACTAAACT
TGAAGAACAAGTTCAAGAATTAGAAAGCCTCATATCCTCTTTGCAGCAACAGTTGAAAGAAACTGAACAAAACTATGAGGCAGAGATCCA
CTGTTTACAGAAGAGGCTTCAAGCTGTTAGTGAGTCCACGGTTCCGCCAAGCTTACCTGTTGATTCGGTGGTAATTACAGAATCTGATGC
ACAGAGAACAATGTACCCTGGAAGTTGTGTGAAAAAGAATATTGATGGTACAATAGAGTTTTCTGGTGAATTTGGAGTGAAAGAGGAAAC
AAATATCGTTAAGTTGCTTGAAAAACAATACCAAGAACAATTAGAAGAAGAAGTAGCTAAGGTTATTGTGTCAATGAGTATAGCATTTGC
TCAACAAACTGAACTGTCTAGAATATCTGGGGGAAAAGAAAATACTGCATCATCAAAGCAAGCACATGCTGTGTGTCAGCAAGAACAACA
TTATTTTAATGAAATGAAATTATCACAGGATCAAATTGGTTTTCAGACTTTTGAGACAGTGGATGTGAAATTTAAAGAAGAATTTAAACC
ACTTAGTAAAGAGTTAGGAGAACATGGAAAGGAAATTTTATTATCAAATAGTGATCCCCATGATATACCAGAATCAAAGGACTGTGTGCT
GACTATTTCAGAAGAAATGTTCTCCAAAGATAAAACATTTATAGTTAGACAGTCTATTCATGATGAGATTTCAGTGTCAAGCATGGATGC
TTCTAGACAACTAATGTTGAATGAAGAACAGTTGGAAGATATGAGACAGGAACTTGTACGACAATACCAAGAACATCAACAGGCAACGGA
ATTGTTAAGGCAAGCACATATGCGGCAAATGGAGAGACAGCGAGAAGACCAGGAACAGCTACAAGAAGAGATTAAGAGACTTAATAGACA
ATTAGCCCAGAGATCCTCCATAGATAATGAAAACCTGGTTTCAGAGAGAGAGAGGGTGCTTTTAGAGGAGCTGGAAGCACTAAAGCAGCT
GTCTTTAGCTGGAAGAGAGAAGCTGTGTTGTGAGCTGCGCAACAGCAGTACGCAAACACAGAATGGAAATGAAAACCAAGGAGAAGTTGA
AGAACAAACATTTAAAGAAAAGGAATTAGACAGAAAACCTGAAGATGTGCCTCCTGAGATTTTGTCTAATGAAAGGTATGCACTCCAGAA
AGCTAATAATAGACTTTTGAAGATCCTCTTAGAAGTTGTAAAGACAACAGCAGCTGTTGAAGAAACAATTGGTCGCCATGTCCTTGGGAT
TCTAGATAGATCTAGTAAAAGCCAGTCATCTGCCAGCCTAATTTGGAGGTCAGAAGCAGAGGCATCTGTAAAGTCATGTGTCCATGAGGA
ACATACAAGAGTTACAGATGAATCCATTCCCTCTTATTCTGGAAGTGATATGCCAAGAAATGACATTAACATGTGGTCAAAAGTAACTGA
GGAAGGAACAGAGCTGTCACAACGACTTGTGAGGAGTGGTTTTGCTGGAACTGAAATAGACCCTGAAAATGAAGAACTTATGCTGAACAT
TAGCTCTCGACTACAAGCAGCAGTTGAAAAACTCCTAGAAGCCATAAGTGAAACTAGCAGTCAGCTTGAACATGCGAAAGTGACACAGAC
AGAGTTGATGCGTGAGTCATTTAGACAGAAACAAGAAGCAACAGAGTCCCTTAAGTGCCAAGAGGAACTTCGAGAGCGCCTTCATGAGGA
GTCCAGGGCCAGAGAACAGCTAGCTGTGGAGCTCAGTAAGGCTGAGGGCGTCATTGATGGCTATGCAGATGAAAAAACTCTTTTTGAAAG
GCAAATTCAGGAAAAAACTGATATAATAGATCGTCTTGAGCAGGAGTTGTTATGTGCAAGTAACAGGTTGCAAGAATTGGAGGCAGAGCA
ACAGCAGATCCAAGAAGAAAGAGAATTACTGTCCAGACAAAAGGAAGCTATGAAAGCAGAGGCAGGCCCAGTTGAACAACAATTACTACA
GGAGACAGAAAAATTAATGAAGGAAAAACTAGAAGTACAATGTCAAGCTGAAAAAGTACGTGATGACCTTCAAAAACAAGTGAAAGCTCT
AGAAATAGATGTGGAAGAACAAGTCAGTAGGTTTATAGAGCTGGAACAAGAAAAAAATACTGAACTAATGGATTTAAGACAGCAAAACCA
AGCATTGGAAAAGCAGTTAGAAAAAATGAGAAAATTTTTAGATGAGCAAGCCATTGACAGAGAACATGAGAGAGATGTATTCCAACAGGA
AATACAGAAACTAGAACAGCAACTTAAGGTTGTTCCTCGATTCCAGCCTATCAGTGAACATCAAACTAGAGAGGTTGAACAGTTAGCAAA
TCATCTGAAAGAAAAAACAGACAAATGCAGTGAGCTTTTGCTCTCTAAAGAGCAGCTTCAAAGGGATATACAAGAAAGGAATGAAGAAAT
AGAGAAACTGGAGTTCAGAGTAAGAGAACTGGAGCAGGCGCTTCTTGTGAGTGCAGATACTTTTCAAAAGGTAGAGGACCGAAAACACTT
TGGAGCTGTAGAAGCTAAACCAGAATTGTCCCTAGAAGTACAATTGCAGGCTGAACGAGATGCCATAGACAGAAAGGAAAAAGAGATTAC
AAACTTAGAAGAGCAATTAGAACAGTTTAGAGAAGAACTGGAAAATAAGAATGAAGAAGTTCAACAATTACATATGCAATTAGAAATACA
GAAAAAGGAATCTACTACCCGCCTACAAGAACTTGAACAGGAAAACAAATTATTTAAGGATGACATGGAGAAACTGGGACTTGCCATAAA
GGAATCTGATGCCATGTCTACTCAAGACCAACATGTGCTATTTGGGAAATTTGCTCAAATAATACAGGAAAAAGAGGTAGAAATTGACCA
ATTAAATGAACAAGTTACGAAACTCCAGCAGCAACTTAAAATTACAACAGATAACAAGGTTATTGAAGAAAAAAATGAACTGATAAGGGA
TCTTGAAACCCAAATAGAATGTTTGATGAGTGATCAAGAATGTGTGAAGAGAAATAGAGAAGAAGAAATAGAGCAGCTCAATGAAGTGAT
TGAAAAACTTCAACAGGAATTGGCAAATATTGGACAGAAGACATCAATGAATGCTCATTCCCTCTCAGAAGAAGCAGACAGTTTAAAACA
TCAATTGGATGTGGTTATAGCTGAAAAGCTGGCCTTGGAACAGCAAGTAGAAACCGCTAATGAAGAAATGACCTTCATGAAAAATGTACT
TAAAGAAACCAATTTTAAAATGAATCAGCTAACACAGGAATTATTCAGCTTAAAGAGAGAACGTGAAAGTGTGGAAAAGATTCAAAGCAT
ACCAGAGAATAGTGTTAACGTGGCTATAGATCATCTGAGCAAAGACAAACCTGAACTAGAAGTAGTCCTTACAGAGGATGCTCTTAAATC
CCTAGAAAATCAGACATACTTCAAATCTTTTGAAGAAAATGGCAAAGGTTCCATAATTAATTTGGAAACAAGGTTGCTACAACTTGAGAG
CACTGTTAGTGCAAAGGACTTAGAACTTACCCAGTGTTATAAACAAATAAAAGACATGCAAGAACAAGGCCAGTTTGAAACAGAAATGCT
TCAAAAGAAGATTGTAAACCTACAGAAAATAGTTGAAGAAAAAGTGGCTGCTGCTCTTGTCAGTCAAATCCAACTTGAGGCAGTTCAGGA
ATATGCAAAATTCTGTCAAGATAATCAAACAATTTCATCAGAACCTGAAAGAACAAATATTCAGAATTTAAATCAACTAAGAGAAGATGA
GTTGGGGTCAGATATATCAGCATTAACCTTGAGAATATCAGAATTAGAAAGCCAGGTTGTTGAAATGCATACTAGTTTGATTTTAGAAAA
AGAACAAGTAGAAATTGCAGAAAAAAATGTTTTAGAAAAAGAAAAGAAGCTGCTAGAACTACAGAAGCTATTGGAGGGCAATGAGAAAAA
ACAGAGAGAGAAAGAAAAGAAAAGAAGCCCTCAAGATGTTGAAGTTCTCAAGACAACTACTGAGCTATTTCATAGCAATGAAGAAAGTGG
ATTTTTTAATGAACTCGAGGCTCTTAGAGCTGAATCAGTGGCTACCAAAGCAGAACTTGCCAGTTATAAAGAAAAGGCTGAAAAACTTCA
AGAAGAGCTTTTGGTAAAAGAAACAAATATGACATCTCTTCAGAAAGACTTAAGCCAAGTTAGGGATCACCTCGCAGAGGCAAAAGAGAA
ATTGTCCATTTTAGAAAAAGAAGATGAGACTGAGGTACAAGAAAGCAAAAAGGCCTGCATGTTTGAGCCACTTCCTATAAAACTGAGTAA
GAGCATTGCATCCCAGACAGATGGGACTCTGAAGATCAGTAGCAGCAATCAGACTCCACAAATTCTTGTTAAAAATGCAGGAATACAAAT
TAATTTACAGAGTGAATGTTCCTCAGAAGAAGTTACTGAAATAATCAGTCAGTTTACTGAAAAAATTGAGAAGATGCAAGAACTACATGC
TGCTGAAATTTTGGACATGGAATCCAGACATATTTCAGAAACTGAAACCTTAAAGAGGGAACACTATGTTGCCGTTCAGTTACTGAAAGA
GGAATGTGGTACCTTGAAGGCAGTGATACAGTGTCTGAGAAGTAAAGAGGTATTTGGTTTTTATAATATGTGTTTTTCAACATTGTGTGA
TTCTGGATCAGACTGGGGTCAGGGAATTTATCTTACACACAGTCAGGGATTTGACATAGCATCAGAAGGCCGAGGAGAAGAAAGTGAAAG
TGCAACAGATTCCTTTCCAAAGAAAATAAAGGGATTACTGAGAGCTGTCCATAATGAAGGCATGCAGGTGCTTTCTCTCACTGAGTCTCC
CTATAGTGATGGAGAGGACCATTCTATTCAGCAGGTTTCAGAACCTTGGCTAGAAGAGAGAAAAGCTTACATCAATACAATCTCATCTCT
AAAGGATTTAATTACAAAGATGCAACTGCAAAGAGAAGCCGAGGTTTATGATAGTTCTCAATCTCATGAGAGCTTCTCAGACTGGCGAGG
TGAACTACTGCTTGCCCTTCAACAAGTTTTCTTAGAAGAGCGTAGTGTTTTACTAGCAGCATTTCGGACGGAGCTGACAGCTCTAGGTAC
TACAGATGCAGTTGGTTTACTAAACTGTTTGGAACAGAGAATACAAGAACAGGGTGTTGAATATCAAGCAGCTATGGAATGCCTCCAGAA
AGCAGATAGAAGGAGTTTGTTATCTGAAATTCAGGCACTGCATGCACAAATGAATGGTAGGAAAATTACTCTGAAAAGAGAACAAGAGAG
TGAGAAACCAAGCCAAGAACTCTTGGAATATAATATACAGCAGAAGCAGTCTCAAATGCTGGAGATGCAAGTGGAGCTCAGCAGTATGAA
AGACAGAGCAACGGAACTGCAGGAGCAGCTGAGTTCTGAGAAAATGGTGGTTGCTGAACTGAAGAGTGAGCTTGCACAAACTAAATTGGA
ACTAGAAACAACACTCAAGGCACAGCATAAACACCTAAAAGAATTGGAGGCTTTCAGGTTGGAAGTTAAAGATAAGACAGATGAAGTACA
TTTGCTTAATGACACATTAGCAAGTGAACAGAAAAAATCAAGAGAGCTCCAGTGGGCTTTGGAGAAAGAGAAAGCCAAGTTGGGACGCAG
TGAAGAACGGGATAAAGAAGAACTTGAGGATCTGAAGTTTTCACTTGAGAGTCAGAAACAAAGGAATCTTCAGCTAAATCTACTTTTGGA
ACAACAGAAACAACTACTGAACGAATCCCAGCAAAAAATAGAATCACAGAGAATGCTATATGATGCCCAGTTGTCAGAAGAACAAGGTCG
AAACTTAGAGCTTCAGGTACTTCTTGAATCTGAGAAAGTTCGAATTCGGGAAATGAGTAGTACCCTAGATAGGGAGCGGGAATTGCACGC
ACAGCTGCAGAGCAGTGATGGTACTGGACAGTCTCGGCCACCCTTGCCCTCAGAGGACCTACTGAAAGAGCTGCAGAAACAGCTAGAGGA
AAAACACAGTCGCATAGTAGAATTGTTAAATGAGACTGAAAAATATAAACTGGATTCTTTGCAAACACGACAGCAAATGGAAAAAGATAG
GCAGGTTCACAGGAAAACACTGCAGACAGAACAGGAGGCCAACACTGAGGGACAGAAAAAAATGCATGAGCTCCAGTCCAAAGTGGAAGA
TCTTCAGCGCCAGCTGGAAGAGAAAAGACAACAAGTTTATAAGTTAGACCTTGAAGGACAGCGACTACAAGGAATCATGCAGGAATTCCA
GAAGCAAGAACTAGAACGAGAAGAAAAACGAGAAAGTAGAAGAATTCTGTATCAGAACCTTAATGAGCCAACCACGTGGAGCTTAACCAG
TGATAGAACTAGAAATTGGGTTCTTCAACAGAAAATAGAAGGAGAAACAAAAGAATCAAACTACGCTAAATTGATTGAAATGAATGGAGG
AGGAACCGGCTGTAATCATGAATTAGAAATGATCAGACAAAAGCTTCAATGTGTAGCTTCAAAACTACAGGTTCTACCCCAGAAAGCCTC
TGAGAGACTACAGTTTGAAACAGCAGATGATGAAGATTTCATTTGGGTTCAGGAAAATATTGATGAAATTATTTTACAACTACAGAAATT
AACTGGCCAGCAAGGTGAAGAGCCCAGCTTGGTGTCCCCAAGTACTTCTTGTGGCTCATTGACTGAAAGACTACTGAGACAAAATGCTGA
GCTGACAGGGCATATCAGTCAACTGACTGAAGAGAAGAATGACTTAAGGAACATGGTTATGAAGCTGGAAGAGCAGATCAGGTGGTATCG
ACAGACAGGAGCTGGTAGAGATAATTCTTCCAGGTTTTCATTGAATGGTGGTGCCAACATTGAAGCCATCATTGCCTCTGAAAAAGAAGT
ATGGAACAGAGAAAAATTGACTCTCCAGAAATCTTTGAAAAGGGCAGAGGCTGAAGTATACAAACTGAAAGCTGAACTAAGAAATGACTC
TTTACTTCAAACTCTGAGCCCTGATTCTGAACATGTCACTTTAAAGAGAATTTATGGTAAATACTTGAGGGCAGAAAGTTTTCGAAAGGC
TCTCATTTACCAGAAGAAATACCTGCTGCTGTTACTGGGTGGGTTCCAGGAATGTGAAGATGCCACCTTGGCCCTGCTTGCCCGGATGGG
GGGGCAGCCAGCTTTCACGGATCTAGAGGTGATCACCAATCGCCCAAAGGGCTTCACCAGGTTTCGGTCGGCCGTCAGAGTATCCATTGC
AATTTCCAGAATGAAATTTTTGGTTCGACGGTGGCATCGAGTCACAGGTTCTGTTTCCATCAATATTAACAGAGATGGCTTTGGACTGAA
TCAAGGTGCAGAAAAGACTGACTCATTTTATCATTCTTCTGGTGGGCTGGAGTTATATGGAGAACCAAGACATACTACGTATCGCTCAAG
ATCAGATCTGGACTATATTAGGTCCCCTTTACCATTTCAGAATAGGTACCCAGGCACTCCAGCTGATTTCAATCCTGGTTCTTTAGCATG
TTCTCAGCTTCAGAATTACGATCCTGACAGAGCCCTAACAGATTATATCACTCGGCTAGAGGCACTGCAAAGACGACTTGGAACTATACA
GTCAGGTTCAACTACTCAATTTCATGCTGGCATGAGAAGATAATCCTTTGAAACATCATTAATTGAAGTGATTTTAAATAGATTTCCTTT
TGTAAATCAATGGTTCTTTTGTGCTTTTGTATTGTGAATATTCAATGGGACCAATATGAACACAGCTTATGATTGTATACAAATCCCTTG
CCAGCACATGAAAACAAACTGGAATTTGTATATATAAGCATTGTGTATGTATTCATGCACAATAATTATTGAATTACCTGTATATTTGTG
GAATGCTAATTTAAAACATTAAATTATAAACCTTGTGTATTTATCAAATGGGTGAAAAGATTAAACTTTTACGCATTACAATACTGCTGA
ATGTGTAGCTCGAGGTGTCCTGCACTTTTCTTATAAGGCTACTGAAGTTACATGTTTTGCCTAATATATTCTACTGGTGATGAAGACAGA
TAATATCACTTGTAGAGACCTATTTTTGTATAATGGTAGAAGTTTTGAATTTTATGGGGTATTTTGTCAAGTACTGAAATAAAAATGACT

>10112_10112_3_BRAF-AKAP9_BRAF_chr7_140494107_ENST00000288602_AKAP9_chr7_91641742_ENST00000359028_length(amino acids)=3173AA_BP=380
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLD
ALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQ
RCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQE
TGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEE
YNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKE
TEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAK
VIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPH
DIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQL
QEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEI
LSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRN
DINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQ
EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAE
AGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDR
EHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADT
FQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKD
DMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNRE
EEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRE
RESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQ
EQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVV
EMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELA
SYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQ
ILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEVFGF
YNMCFSTLCDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEER
KAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVE
YQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAEL
KSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQ
RNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDL
LKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQ
RLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVAS
KLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVM
KLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGK
YLRAESFRKALIYQKKYLLLLLGGFQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKFLVRRWHRVTGSVSI
NINRDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYIRSPLPFQNRYPGTPADFNPGSLACSQLQNYDPDRALTDYITRLE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for BRAF-AKAP9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BRAF-AKAP9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneBRAFP15056DB08881VemurafenibInhibitorSmall moleculeApproved
HgeneBRAFP15056DB08881VemurafenibInhibitorSmall moleculeApproved
HgeneBRAFP15056DB08881VemurafenibInhibitorSmall moleculeApproved
HgeneBRAFP15056DB08896RegorafenibInhibitorSmall moleculeApproved
HgeneBRAFP15056DB08896RegorafenibInhibitorSmall moleculeApproved
HgeneBRAFP15056DB08896RegorafenibInhibitorSmall moleculeApproved
HgeneBRAFP15056DB14840RipretinibInhibitorSmall moleculeApproved
HgeneBRAFP15056DB14840RipretinibInhibitorSmall moleculeApproved
HgeneBRAFP15056DB14840RipretinibInhibitorSmall moleculeApproved
HgeneBRAFP15056DB00398SorafenibInhibitorSmall moleculeApproved|Investigational
HgeneBRAFP15056DB00398SorafenibInhibitorSmall moleculeApproved|Investigational
HgeneBRAFP15056DB00398SorafenibInhibitorSmall moleculeApproved|Investigational
HgeneBRAFP15056DB08912DabrafenibAntagonist|InhibitorSmall moleculeApproved|Investigational
HgeneBRAFP15056DB08912DabrafenibAntagonist|InhibitorSmall moleculeApproved|Investigational
HgeneBRAFP15056DB08912DabrafenibAntagonist|InhibitorSmall moleculeApproved|Investigational
HgeneBRAFP15056DB11718EncorafenibInhibitorSmall moleculeApproved|Investigational
HgeneBRAFP15056DB11718EncorafenibInhibitorSmall moleculeApproved|Investigational
HgeneBRAFP15056DB11718EncorafenibInhibitorSmall moleculeApproved|Investigational
HgeneBRAFP15056DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
HgeneBRAFP15056DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
HgeneBRAFP15056DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational

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Related Diseases for BRAF-AKAP9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBRAFC0025202melanoma24CGI;CTD_human;UNIPROT
HgeneBRAFC1275081Cardio-facio-cutaneous syndrome14CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneBRAFC0009402Colorectal Carcinoma8CTD_human;UNIPROT
HgeneBRAFC0028326Noonan Syndrome8CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneBRAFC0238463Papillary thyroid carcinoma8CTD_human;ORPHANET
HgeneBRAFC0040136Thyroid Neoplasm6CGI;CTD_human
HgeneBRAFC0151468Thyroid Gland Follicular Adenoma6CTD_human
HgeneBRAFC0175704LEOPARD Syndrome6CLINGEN;GENOMICS_ENGLAND
HgeneBRAFC0549473Thyroid carcinoma6CGI;CTD_human
HgeneBRAFC3150970NOONAN SYNDROME 75CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneBRAFC0009404Colorectal Neoplasms4CTD_human
HgeneBRAFC3150971LEOPARD SYNDROME 34CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneBRAFC1519086Pilomyxoid astrocytoma3ORPHANET
HgeneBRAFC0004565Melanoma, B162CTD_human
HgeneBRAFC0009075Melanoma, Cloudman S912CTD_human
HgeneBRAFC0018598Melanoma, Harding-Passey2CTD_human
HgeneBRAFC0023443Hairy Cell Leukemia2CGI;ORPHANET
HgeneBRAFC0025205Melanoma, Experimental2CTD_human
HgeneBRAFC0033578Prostatic Neoplasms2CTD_human
HgeneBRAFC0152013Adenocarcinoma of lung (disorder)2CGI;CTD_human
HgeneBRAFC0376358Malignant neoplasm of prostate2CTD_human
HgeneBRAFC0587248Costello syndrome (disorder)2CLINGEN;CTD_human
HgeneBRAFC3501843Nonmedullary Thyroid Carcinoma2CTD_human
HgeneBRAFC3501844Familial Nonmedullary Thyroid Cancer2CTD_human
HgeneBRAFC0002448Ameloblastoma1CTD_human
HgeneBRAFC0004114Astrocytoma1CTD_human
HgeneBRAFC0010276Craniopharyngioma1CTD_human;ORPHANET
HgeneBRAFC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
HgeneBRAFC0017638Glioma1CGI;CTD_human
HgeneBRAFC0019621Histiocytosis, Langerhans-Cell1CGI;ORPHANET
HgeneBRAFC0022665Kidney Neoplasm1CTD_human
HgeneBRAFC0023903Liver neoplasms1CTD_human
HgeneBRAFC0024232Lymphatic Metastasis1CTD_human
HgeneBRAFC0024694Mandibular Neoplasms1CTD_human
HgeneBRAFC0027659Neoplasms, Experimental1CTD_human
HgeneBRAFC0027962Melanocytic nevus1GENOMICS_ENGLAND
HgeneBRAFC0036920Sezary Syndrome1CTD_human
HgeneBRAFC0041409Turner Syndrome, Male1CTD_human
HgeneBRAFC0079773Lymphoma, T-Cell, Cutaneous1CTD_human
HgeneBRAFC0205768Subependymal Giant Cell Astrocytoma1CTD_human
HgeneBRAFC0206686Adrenocortical carcinoma1CTD_human
HgeneBRAFC0206754Neuroendocrine Tumors1CTD_human
HgeneBRAFC0259783mixed gliomas1CTD_human
HgeneBRAFC0278875Adult Craniopharyngioma1CTD_human
HgeneBRAFC0280783Juvenile Pilocytic Astrocytoma1CTD_human
HgeneBRAFC0280785Diffuse Astrocytoma1CTD_human
HgeneBRAFC0334579Anaplastic astrocytoma1CGI;CTD_human
HgeneBRAFC0334580Protoplasmic astrocytoma1CTD_human
HgeneBRAFC0334581Gemistocytic astrocytoma1CTD_human
HgeneBRAFC0334582Fibrillary Astrocytoma1CTD_human
HgeneBRAFC0334583Pilocytic Astrocytoma1CGI;CTD_human
HgeneBRAFC0338070Childhood Cerebral Astrocytoma1CTD_human
HgeneBRAFC0345904Malignant neoplasm of liver1CTD_human
HgeneBRAFC0376407Granulomatous Slack Skin1CTD_human
HgeneBRAFC0406803Syringocystadenoma Papilliferum1GENOMICS_ENGLAND
HgeneBRAFC0431128Papillary craniopharyngioma1CTD_human
HgeneBRAFC0431129Adamantinous Craniopharyngioma1CTD_human
HgeneBRAFC0547065Mixed oligoastrocytoma1CTD_human
HgeneBRAFC0555198Malignant Glioma1CTD_human
HgeneBRAFC0596263Carcinogenesis1CTD_human
HgeneBRAFC0684249Carcinoma of lung1CGI;UNIPROT
HgeneBRAFC0740457Malignant neoplasm of kidney1CTD_human
HgeneBRAFC0750935Cerebral Astrocytoma1CTD_human
HgeneBRAFC0750936Intracranial Astrocytoma1CTD_human
HgeneBRAFC0751061Craniopharyngioma, Child1CTD_human
HgeneBRAFC0920269Microsatellite Instability1CTD_human
HgeneBRAFC1527404Female Pseudo-Turner Syndrome1CTD_human
HgeneBRAFC1704230Grade I Astrocytoma1CTD_human
HgeneBRAFC1721098Replication Error Phenotype1CTD_human
HgeneBRAFC2239176Liver carcinoma1CTD_human
HgeneBRAFC4551484Leopard Syndrome 11GENOMICS_ENGLAND
HgeneBRAFC4551602Noonan Syndrome 11CTD_human
HgeneBRAFC4721532Lymphoma, Non-Hodgkin, Familial1UNIPROT
HgeneBRAFC4733333familial non-medullary thyroid cancer1GENOMICS_ENGLAND
TgeneC2678483Long Qt Syndrome 114CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0035828Romano-Ward Syndrome1ORPHANET
TgeneC0037274Dermatologic disorders1CTD_human
TgeneC0274861Arsenic Poisoning, Inorganic1CTD_human
TgeneC0274862Nervous System, Organic Arsenic Poisoning1CTD_human
TgeneC0311375Arsenic Poisoning1CTD_human
TgeneC0751851Arsenic Encephalopathy1CTD_human
TgeneC0751852Arsenic Induced Polyneuropathy1CTD_human
TgeneC1142166Brugada Syndrome (disorder)1ORPHANET