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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:BRAF-CUX1 (FusionGDB2 ID:HG673TG1523) |
Fusion Gene Summary for BRAF-CUX1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BRAF-CUX1 | Fusion gene ID: hg673tg1523 | Hgene | Tgene | Gene symbol | BRAF | CUX1 | Gene ID | 673 | 1523 |
| Gene name | B-Raf proto-oncogene, serine/threonine kinase | cut like homeobox 1 | |
| Synonyms | B-RAF1|B-raf|BRAF1|NS7|RAFB1 | CASP|CDP|CDP/Cut|CDP1|COY1|CUTL1|CUX|Clox|Cux/CDP|GDDI|GOLIM6|Nbla10317|p100|p110|p200|p75 | |
| Cytomap | ('BRAF')('CUX1') 7q34 | 7q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase B-raf94 kDa B-raf proteinB-Raf proto-oncogene serine/threonine-protein kinase (p94)B-Raf serine/threonine-proteinmurine sarcoma viral (v-raf) oncogene homolog B1proto-oncogene B-Rafv-raf murine sarcoma viral oncogene | protein CASPHomeobox protein cut-like 1CCAAT displacement proteinCUX1 gene Alternatively Spliced Productcut homologgolgi integral membrane protein 6homeobox protein cux-1putative protein product of Nbla10317 | |
| Modification date | 20200329 | 20200320 | |
| UniProtAcc | P15056 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000288602, | ENST00000288602, | |
| Fusion gene scores | * DoF score | 28 X 21 X 11=6468 | 26 X 23 X 9=5382 |
| # samples | 32 | 29 | |
| ** MAII score | log2(32/6468*10)=-4.3371758685863 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(29/5382*10)=-4.21401758562548 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: BRAF [Title/Abstract] AND CUX1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | BRAF(140500162)-CUX1(101801840), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | BRAF-CUX1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BRAF-CUX1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BRAF-CUX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. BRAF-CUX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CUX1-BRAF seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CUX1-BRAF seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | BRAF | GO:0000186 | activation of MAPKK activity | 29433126 |
| Hgene | BRAF | GO:0006468 | protein phosphorylation | 17563371 |
| Hgene | BRAF | GO:0010828 | positive regulation of glucose transmembrane transport | 23010278 |
| Hgene | BRAF | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 19667065 |
| Hgene | BRAF | GO:0043066 | negative regulation of apoptotic process | 19667065 |
| Hgene | BRAF | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 22065586 |
| Hgene | BRAF | GO:0071277 | cellular response to calcium ion | 18567582 |
| Hgene | BRAF | GO:0090150 | establishment of protein localization to membrane | 23010278 |
| Fusion gene breakpoints across BRAF (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across CUX1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | PAAD | TCGA-F2-A44H-01A | BRAF | chr7 | 140500162 | - | CUX1 | chr7 | 101801840 | + |
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Fusion Gene ORF analysis for BRAF-CUX1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000288602 | ENST00000560541 | BRAF | chr7 | 140500162 | - | CUX1 | chr7 | 101801840 | + |
| In-frame | ENST00000288602 | ENST00000292535 | BRAF | chr7 | 140500162 | - | CUX1 | chr7 | 101801840 | + |
| In-frame | ENST00000288602 | ENST00000292538 | BRAF | chr7 | 140500162 | - | CUX1 | chr7 | 101801840 | + |
| In-frame | ENST00000288602 | ENST00000360264 | BRAF | chr7 | 140500162 | - | CUX1 | chr7 | 101801840 | + |
| In-frame | ENST00000288602 | ENST00000393824 | BRAF | chr7 | 140500162 | - | CUX1 | chr7 | 101801840 | + |
| In-frame | ENST00000288602 | ENST00000425244 | BRAF | chr7 | 140500162 | - | CUX1 | chr7 | 101801840 | + |
| In-frame | ENST00000288602 | ENST00000437600 | BRAF | chr7 | 140500162 | - | CUX1 | chr7 | 101801840 | + |
| In-frame | ENST00000288602 | ENST00000546411 | BRAF | chr7 | 140500162 | - | CUX1 | chr7 | 101801840 | + |
| In-frame | ENST00000288602 | ENST00000547394 | BRAF | chr7 | 140500162 | - | CUX1 | chr7 | 101801840 | + |
| In-frame | ENST00000288602 | ENST00000549414 | BRAF | chr7 | 140500162 | - | CUX1 | chr7 | 101801840 | + |
| In-frame | ENST00000288602 | ENST00000550008 | BRAF | chr7 | 140500162 | - | CUX1 | chr7 | 101801840 | + |
| In-frame | ENST00000288602 | ENST00000556210 | BRAF | chr7 | 140500162 | - | CUX1 | chr7 | 101801840 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000288602 | BRAF | chr7 | 140500162 | - | ENST00000437600 | CUX1 | chr7 | 101801840 | + | 3232 | 1041 | 61 | 2364 | 767 |
| ENST00000288602 | BRAF | chr7 | 140500162 | - | ENST00000292538 | CUX1 | chr7 | 101801840 | + | 3238 | 1041 | 61 | 2370 | 769 |
| ENST00000288602 | BRAF | chr7 | 140500162 | - | ENST00000393824 | CUX1 | chr7 | 101801840 | + | 2753 | 1041 | 61 | 2364 | 767 |
| ENST00000288602 | BRAF | chr7 | 140500162 | - | ENST00000547394 | CUX1 | chr7 | 101801840 | + | 3238 | 1041 | 61 | 2370 | 769 |
| ENST00000288602 | BRAF | chr7 | 140500162 | - | ENST00000360264 | CUX1 | chr7 | 101801840 | + | 14076 | 1041 | 61 | 4884 | 1607 |
| ENST00000288602 | BRAF | chr7 | 140500162 | - | ENST00000425244 | CUX1 | chr7 | 101801840 | + | 3238 | 1041 | 61 | 2370 | 769 |
| ENST00000288602 | BRAF | chr7 | 140500162 | - | ENST00000292535 | CUX1 | chr7 | 101801840 | + | 14076 | 1041 | 61 | 4884 | 1607 |
| ENST00000288602 | BRAF | chr7 | 140500162 | - | ENST00000549414 | CUX1 | chr7 | 101801840 | + | 4819 | 1041 | 61 | 4818 | 1586 |
| ENST00000288602 | BRAF | chr7 | 140500162 | - | ENST00000556210 | CUX1 | chr7 | 101801840 | + | 4411 | 1041 | 61 | 4410 | 1450 |
| ENST00000288602 | BRAF | chr7 | 140500162 | - | ENST00000550008 | CUX1 | chr7 | 101801840 | + | 4717 | 1041 | 61 | 4716 | 1552 |
| ENST00000288602 | BRAF | chr7 | 140500162 | - | ENST00000546411 | CUX1 | chr7 | 101801840 | + | 4579 | 1041 | 61 | 4578 | 1506 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000288602 | ENST00000437600 | BRAF | chr7 | 140500162 | - | CUX1 | chr7 | 101801840 | + | 0.008954197 | 0.9910458 |
| ENST00000288602 | ENST00000292538 | BRAF | chr7 | 140500162 | - | CUX1 | chr7 | 101801840 | + | 0.009490056 | 0.9905099 |
| ENST00000288602 | ENST00000393824 | BRAF | chr7 | 140500162 | - | CUX1 | chr7 | 101801840 | + | 0.00824429 | 0.9917557 |
| ENST00000288602 | ENST00000547394 | BRAF | chr7 | 140500162 | - | CUX1 | chr7 | 101801840 | + | 0.009490056 | 0.9905099 |
| ENST00000288602 | ENST00000360264 | BRAF | chr7 | 140500162 | - | CUX1 | chr7 | 101801840 | + | 0.000201918 | 0.9997981 |
| ENST00000288602 | ENST00000425244 | BRAF | chr7 | 140500162 | - | CUX1 | chr7 | 101801840 | + | 0.009490056 | 0.9905099 |
| ENST00000288602 | ENST00000292535 | BRAF | chr7 | 140500162 | - | CUX1 | chr7 | 101801840 | + | 0.000201918 | 0.9997981 |
| ENST00000288602 | ENST00000549414 | BRAF | chr7 | 140500162 | - | CUX1 | chr7 | 101801840 | + | 0.004669635 | 0.99533033 |
| ENST00000288602 | ENST00000556210 | BRAF | chr7 | 140500162 | - | CUX1 | chr7 | 101801840 | + | 0.004534435 | 0.9954656 |
| ENST00000288602 | ENST00000550008 | BRAF | chr7 | 140500162 | - | CUX1 | chr7 | 101801840 | + | 0.00410532 | 0.9958947 |
| ENST00000288602 | ENST00000546411 | BRAF | chr7 | 140500162 | - | CUX1 | chr7 | 101801840 | + | 0.004225296 | 0.9957747 |
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Fusion Genomic Features for BRAF-CUX1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| BRAF | chr7 | 140500161 | - | CUX1 | chr7 | 101801839 | + | 1.13E-06 | 0.9999989 |
| BRAF | chr7 | 140500161 | - | CUX1 | chr7 | 101801839 | + | 1.13E-06 | 0.9999989 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for BRAF-CUX1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:140500162/chr7:101801840) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BRAF | . |
| FUNCTION: Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000305}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | BRAF | chr7:140500162 | chr7:101801840 | ENST00000288602 | - | 7 | 18 | 122_129 | 326 | 767.0 | Compositional bias | Note=Poly-Ser |
| Hgene | BRAF | chr7:140500162 | chr7:101801840 | ENST00000288602 | - | 7 | 18 | 6_11 | 326 | 767.0 | Compositional bias | Note=Poly-Gly |
| Hgene | BRAF | chr7:140500162 | chr7:101801840 | ENST00000288602 | - | 7 | 18 | 155_227 | 326 | 767.0 | Domain | RBD |
| Hgene | BRAF | chr7:140500162 | chr7:101801840 | ENST00000288602 | - | 7 | 18 | 234_280 | 326 | 767.0 | Zinc finger | Phorbol-ester/DAG-type |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000292538 | 7 | 23 | 502_556 | 235 | 679.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000393824 | 6 | 22 | 502_556 | 198 | 640.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000437600 | 7 | 23 | 502_556 | 235 | 677.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000547394 | 6 | 22 | 502_556 | 219 | 663.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000292535 | 7 | 24 | 1406_1438 | 224 | 1506.0 | Compositional bias | Note=Ala-rich | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000360264 | 7 | 24 | 1406_1438 | 235 | 1517.0 | Compositional bias | Note=Ala-rich | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000425244 | 6 | 22 | 1406_1438 | 189 | 633.0 | Compositional bias | Note=Ala-rich | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000546411 | 7 | 24 | 1406_1438 | 224 | 1404.0 | Compositional bias | Note=Ala-rich | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000549414 | 7 | 23 | 1406_1438 | 224 | 1484.0 | Compositional bias | Note=Ala-rich | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000550008 | 7 | 22 | 1406_1438 | 224 | 1450.0 | Compositional bias | Note=Ala-rich | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000556210 | 7 | 22 | 1406_1438 | 224 | 1348.0 | Compositional bias | Note=Ala-rich | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000292535 | 7 | 24 | 1117_1204 | 224 | 1506.0 | DNA binding | CUT 3 | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000292535 | 7 | 24 | 1244_1303 | 224 | 1506.0 | DNA binding | Homeobox | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000292535 | 7 | 24 | 542_629 | 224 | 1506.0 | DNA binding | CUT 1 | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000292535 | 7 | 24 | 934_1021 | 224 | 1506.0 | DNA binding | CUT 2 | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000360264 | 7 | 24 | 1117_1204 | 235 | 1517.0 | DNA binding | CUT 3 | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000360264 | 7 | 24 | 1244_1303 | 235 | 1517.0 | DNA binding | Homeobox | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000360264 | 7 | 24 | 542_629 | 235 | 1517.0 | DNA binding | CUT 1 | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000360264 | 7 | 24 | 934_1021 | 235 | 1517.0 | DNA binding | CUT 2 | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000425244 | 6 | 22 | 1117_1204 | 189 | 633.0 | DNA binding | CUT 3 | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000425244 | 6 | 22 | 1244_1303 | 189 | 633.0 | DNA binding | Homeobox | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000425244 | 6 | 22 | 542_629 | 189 | 633.0 | DNA binding | CUT 1 | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000425244 | 6 | 22 | 934_1021 | 189 | 633.0 | DNA binding | CUT 2 | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000546411 | 7 | 24 | 1117_1204 | 224 | 1404.0 | DNA binding | CUT 3 | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000546411 | 7 | 24 | 1244_1303 | 224 | 1404.0 | DNA binding | Homeobox | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000546411 | 7 | 24 | 542_629 | 224 | 1404.0 | DNA binding | CUT 1 | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000546411 | 7 | 24 | 934_1021 | 224 | 1404.0 | DNA binding | CUT 2 | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000549414 | 7 | 23 | 1117_1204 | 224 | 1484.0 | DNA binding | CUT 3 | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000549414 | 7 | 23 | 1244_1303 | 224 | 1484.0 | DNA binding | Homeobox | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000549414 | 7 | 23 | 542_629 | 224 | 1484.0 | DNA binding | CUT 1 | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000549414 | 7 | 23 | 934_1021 | 224 | 1484.0 | DNA binding | CUT 2 | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000550008 | 7 | 22 | 1117_1204 | 224 | 1450.0 | DNA binding | CUT 3 | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000550008 | 7 | 22 | 1244_1303 | 224 | 1450.0 | DNA binding | Homeobox | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000550008 | 7 | 22 | 542_629 | 224 | 1450.0 | DNA binding | CUT 1 | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000550008 | 7 | 22 | 934_1021 | 224 | 1450.0 | DNA binding | CUT 2 | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000556210 | 7 | 22 | 1117_1204 | 224 | 1348.0 | DNA binding | CUT 3 | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000556210 | 7 | 22 | 1244_1303 | 224 | 1348.0 | DNA binding | Homeobox | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000556210 | 7 | 22 | 542_629 | 224 | 1348.0 | DNA binding | CUT 1 | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000556210 | 7 | 22 | 934_1021 | 224 | 1348.0 | DNA binding | CUT 2 | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000292538 | 7 | 23 | 641_678 | 235 | 679.0 | Topological domain | Lumenal | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000393824 | 6 | 22 | 641_678 | 198 | 640.0 | Topological domain | Lumenal | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000437600 | 7 | 23 | 641_678 | 235 | 677.0 | Topological domain | Lumenal | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000547394 | 6 | 22 | 641_678 | 219 | 663.0 | Topological domain | Lumenal | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000292538 | 7 | 23 | 620_640 | 235 | 679.0 | Transmembrane | Helical%3B Anchor for type IV membrane protein | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000393824 | 6 | 22 | 620_640 | 198 | 640.0 | Transmembrane | Helical%3B Anchor for type IV membrane protein | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000437600 | 7 | 23 | 620_640 | 235 | 677.0 | Transmembrane | Helical%3B Anchor for type IV membrane protein | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000547394 | 6 | 22 | 620_640 | 219 | 663.0 | Transmembrane | Helical%3B Anchor for type IV membrane protein |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | BRAF | chr7:140500162 | chr7:101801840 | ENST00000288602 | - | 7 | 18 | 428_432 | 326 | 767.0 | Compositional bias | Note=Poly-Ser |
| Hgene | BRAF | chr7:140500162 | chr7:101801840 | ENST00000288602 | - | 7 | 18 | 457_717 | 326 | 767.0 | Domain | Protein kinase |
| Hgene | BRAF | chr7:140500162 | chr7:101801840 | ENST00000288602 | - | 7 | 18 | 463_471 | 326 | 767.0 | Nucleotide binding | ATP |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000292535 | 7 | 24 | 56_407 | 224 | 1506.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000292538 | 7 | 23 | 67_450 | 235 | 679.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000360264 | 7 | 24 | 56_407 | 235 | 1517.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000393824 | 6 | 22 | 67_450 | 198 | 640.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000425244 | 6 | 22 | 56_407 | 189 | 633.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000437600 | 7 | 23 | 67_450 | 235 | 677.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000546411 | 7 | 24 | 56_407 | 224 | 1404.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000547394 | 6 | 22 | 67_450 | 219 | 663.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000549414 | 7 | 23 | 56_407 | 224 | 1484.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000550008 | 7 | 22 | 56_407 | 224 | 1450.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000556210 | 7 | 22 | 56_407 | 224 | 1348.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000292538 | 7 | 23 | 1_619 | 235 | 679.0 | Topological domain | Cytoplasmic | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000393824 | 6 | 22 | 1_619 | 198 | 640.0 | Topological domain | Cytoplasmic | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000437600 | 7 | 23 | 1_619 | 235 | 677.0 | Topological domain | Cytoplasmic | |
| Tgene | CUX1 | chr7:140500162 | chr7:101801840 | ENST00000547394 | 6 | 22 | 1_619 | 219 | 663.0 | Topological domain | Cytoplasmic |
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Fusion Gene Sequence for BRAF-CUX1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >10121_10121_1_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000292535_length(transcript)=14076nt_BP=1041nt CGCCTCCCTTCCCCCTCCCCGCCCGACAGCGGCCGCTCGGGCCCCGGCTCTCGGTTATAAGATGGCGGCGCTGAGCGGTGGCGGTGGTGG CGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGCGCCGGCGCCGCGGCCTCTTCGGCTGCGGA CCCTGCCATTCCGGAGGAGGTGTGGAATATCAAACAAATGATTAAGTTGACACAGGAACATATAGAGGCCCTATTGGACAAATTTGGTGG GGAGCATAATCCACCATCAATATATCTGGAGGCCTATGAAGAATACACCAGCAAGCTAGATGCACTCCAACAAAGAGAACAACAGTTATT GGAATCTCTGGGGAACGGAACTGATTTTTCTGTTTCTAGCTCTGCATCAATGGATACCGTTACATCTTCTTCCTCTTCTAGCCTTTCAGT GCTACCTTCATCTCTTTCAGTTTTTCAAAATCCCACAGATGTGGCACGGAGCAACCCCAAGTCACCACAAAAACCTATCGTTAGAGTCTT CCTGCCCAACAAACAGAGGACAGTGGTACCTGCAAGGTGTGGAGTTACAGTCCGAGACAGTCTAAAGAAAGCACTGATGATGAGAGGTCT AATCCCAGAGTGCTGTGCTGTTTACAGAATTCAGGATGGAGAGAAGAAACCAATTGGTTGGGACACTGATATTTCCTGGCTTACTGGAGA AGAATTGCATGTGGAAGTGTTGGAGAATGTTCCACTTACAACACACAACTTTGTACGAAAAACGTTTTTCACCTTAGCATTTTGTGACTT TTGTCGAAAGCTGCTTTTCCAGGGTTTCCGCTGTCAAACATGTGGTTATAAATTTCACCAGCGTTGTAGTACAGAAGTTCCACTGATGTG TGTTAATTATGACCAACTTGATTTGCTGTTTGTCTCCAAGTTCTTTGAACACCACCCAATACCACAGGAAGAGGCGTCCTTAGCAGAGAC TGCCCTAACATCTGGATCATCCCCTTCCGCACCCGCCTCGGACTCTATTGGGGCCGACGAGATTGAAATGATCATGACGGACCTTGAAAG GGCAAACCAGAGGGCAGAGGTGGCTCAGAGAGAGGCGGAGACCTTAAGGGAACAGCTCTCATCGGCCAATCACTCCCTCCAGCTGGCCTC ACAGATCCAGAAGGCACCAGACGTGGAGCAGGCCATAGAGGTGCTGACCCGCTCCAGCCTAGAAGTTGAGTTGGCCGCCAAGGAGCGGGA GATCGCACAGCTGGTGGAGGACGTGCAGAGACTCCAGGCCAGCCTCACCAAGCTGCGGGAGAATTCGGCCAGCCAGATCTCACAGCTTGA GCAGCAGCTGAGCGCCAAAAACAGCACACTCAAACAACTGGAAGAAAAACTCAAAGGCCAGGCTGACTATGAAGAGGTGAAGAAAGAGCT GAACATTCTGAAGTCCATGGAGTTTGCACCGTCCGAGGGCGCTGGGACACAGGATGCGGCCAAGCCCCTGGAGGTGCTGTTGCTGGAGAA GAACCGCTCGCTGCAGTCCGAGAACGCCGCGCTGCGCATCTCCAACAGCGACCTGAGCGGGTCAGCCAGGAGGAAAGGGAAAGACCAGCC TGAAAGTCGGCGCCCGGGATCTTTGCCGGCCCCCCCTCCTTCTCAGTTGCCCCGCAACCCGGGGGAGCAGGCTTCCAATACTAATGGTAC ACACCAGTTCTCACCAGCGGGGTTAAGTCAAGACTTTTTCAGCTCATCCCTGGCAAGCCCCAGCCTACCCCTGGCTTCTACAGGAAAATT TGCACTAAACTCTCTTCTCCAGCGGCAGCTAATGCAGTCCTTCTACTCCAAGGCTATGCAGGAAGCCGGAAGCACAAGCATGATTTTTTC AACAGGTCCATACAGCACAAACTCCATATCTTCCCAAAGTCCATTACAACAAAGCCCAGATGTCAATGGCATGGCCCCATCCCCCAGCCA GTCAGAAAGTGCTGGGAGCGTCTCCGAGGGCGAGGAGATGGACACTGCAGAAATCGCCCGGCAGGTCAAAGAGCAGCTGATTAAGCACAA TATCGGACAACGTATTTTCGGACATTATGTGTTGGGACTGTCTCAAGGGTCCGTGAGCGAGATTCTGGCCCGGCCCAAGCCATGGAATAA ACTGACTGTTCGTGGCAAGGAGCCATTTCACAAGATGAAACAGTTCCTCTCCGATGAGCAGAACATCCTGGCCCTCCGTAGCATCCAAGG CAGACAAAGAGAGAATCCAGGCCAGAGCCTGAACAGACTATTTCAGGAAGTACCGAAACGAAGAAATGGGTCTGAAGGTAACATCACCAC CCGGATCCGAGCCTCGGAGACTGGCTCTGATGAAGCCATCAAGTCCATCCTAGAGCAAGCCAAGAGGGAGCTCCAAGTGCAGAAAACTGC AGAGCCGGCCCAGCCTTCCTCCGCATCCGGCAGCGGGAACTCTGATGACGCCATCCGCTCCATCCTGCAGCAAGCCCGCCGGGAGATGGA GGCCCAGCAGGCTGCCCTCGACCCTGCCTTAAAGCAGGCACCACTGTCCCAGAGTGACATCACCATCCTCACCCCCAAGCTTCTGTCCAC CTCGCCCATGCCCACCGTGTCCAGCTACCCACCTCTCGCCATCTCCCTGAAGAAGCCCTCCGCAGCTCCTGAGGCCGGTGCCTCTGCTCT GCCGAACCCCCCGGCCCTCAAAAAGGAGGCCCAGGACGCCCCCGGGCTGGACCCCCAGGGAGCAGCCGATTGTGCACAAGGGGTCCTGAG ACAGGTGAAAAATGAGGTGGGCCGCAGCGGTGCCTGGAAGGACCACTGGTGGAGCGCGGTGCAGCCGGAGAGAAGAAATGCCGCCTCCTC CGAGGAGGCCAAGGCCGAAGAAACGGGCGGCGGGAAAGAGAAGGGCAGCGGTGGCAGCGGAGGTGGCAGCCAGCCTCGGGCCGAGCGCAG TCAGCTCCAGGGACCCTCGTCGTCAGAGTACTGGAAGGAGTGGCCCAGCGCTGAGTCCCCATACTCCCAGAGCTCAGAGCTGAGTCTGAC CGGGGCCAGCCGCAGCGAGACACCACAGAACAGCCCCCTGCCATCCTCCCCGATCGTGCCCATGTCCAAGCCCACCAAGCCCTCGGTCCC CCCGCTGACCCCCGAGCAGTACGAGGTCTACATGTACCAGGAGGTGGACACCATCGAGCTCACCCGGCAGGTTAAGGAAAAGCTGGCCAA GAACGGCATCTGCCAGAGAATCTTCGGGGAGAAGGTGCTGGGCCTGTCCCAGGGCAGCGTCAGCGACATGCTGTCCCGACCGAAGCCATG GAGCAAGCTGACGCAGAAAGGCCGAGAACCCTTCATCCGGATGCAGCTCTGGCTGAACGGCGAGCTAGGCCAGGGTGTTCTACCCGTCCA GGGCCAGCAGCAAGGGCCAGTCCTCCACTCCGTGACATCGCTCCAGGACCCGCTGCAGCAGGGCTGTGTGAGCTCAGAAAGCACTCCAAA GACCTCCGCCAGCTGCAGCCCTGCCCCTGAGTCCCCGATGAGTTCCAGTGAGTCGGTGAAGAGCCTGACCGAGCTGGTCCAGCAGCCCTG TCCCCCCATCGAGGCGAGCAAGGACAGCAAGCCACCAGAGCCCAGTGACCCGCCAGCATCCGACTCCCAGCCCACAACCCCGCTGCCTCT CTCCGGACACTCGGCCCTCAGCATCCAAGAATTAGTAGCCATGTCCCCGGAGCTGGACACCTACGGCATAACCAAGCGGGTGAAGGAGGT GCTGACGGACAACAACCTCGGCCAGCGCTTATTTGGGGAGACCATCTTAGGGCTCACCCAAGGCTCTGTCTCTGACCTCCTTGCCCGCCC CAAACCCTGGCATAAGCTCAGTCTGAAAGGACGAGAGCCCTTCGTCCGGATGCAGCTGTGGCTGAACGACCCCAACAATGTGGAGAAGCT GATGGACATGAAACGGATGGAGAAGAAAGCCTACATGAAGCGGCGGCACAGCTCAGTCAGTGACAGCCAGCCCTGCGAACCGCCCTCTGT CGGCACCGAGTACAGCCAGGGCGCCAGCCCCCAGCCCCAGCACCAGCTGAAGAAACCCCGGGTGGTGCTGGCTCCGGAGGAGAAGGAGGC GCTGAAACGAGCGTATCAGCAAAAGCCATACCCGTCACCAAAAACCATCGAAGACCTCGCCACCCAGCTCAACCTGAAAACCAGCACCGT CATCAACTGGTTCCACAACTACAGGTCTCGGATCCGCAGAGAACTGTTCATTGAGGAAATTCAGGCCGGGAGTCAGGGCCAGGCGGGCGC CAGCGACTCACCCTCGGCCCGCAGCGGCCGGGCGGCGCCCAGCTCGGAGGGCGACAGCTGCGACGGCGTGGAGGCCACTGAGGGCCCAGG CAGCGCCGACACCGAGGAGCCCAAGTCTCAGGGAGAGGCCGAGCGGGAGGAGGTGCCGCGGCCGGCGGAGCAGACGGAGCCGCCGCCCTC GGGGACCCCGGGCCCGGACGACGCCCGCGACGACGACCACGAGGGAGGCCCCGTGGAAGGCCCGGGGCCCCTGCCCAGCCCCGCCTCCGC GACCGCCACCGCCGCGCCCGCGGCCCCCGAGGACGCCGCTACCTCAGCCGCCGCCGCGCCGGGGGAGGGCCCCGCGGCCCCGAGCTCCGC GCCGCCGCCCAGCAACAGCAGCAGCAGCAGCGCCCCCCGCAGGCCCAGCTCGCTGCAGAGCCTTTTCGGCCTCCCCGAGGCCGCGGGCGC CCGGGACTCGCGCGACAACCCCCTGCGCAAGAAGAAGGCCGCGAACTTGAACAGCATCATCCACCGCCTGGAGAAGGCCGCCAGCCGGGA GGAACCTATCGAATGGGAGTTCTGAGGGGCCGCGGCCCTGGGGCGGGCAGCCAGGCTGGGCCGCAAGGGCCTGGACGGGGTCGGACGGGG CAGGCGCTGCGGACACCGTGGCCTGGGCTTGGCCCGCGGCCTGCACCGACCCCGGGCCGGACCTGAGCCCGCAGCCCAGACCCCCTCCAC GGTCCGCGGCCTGCACCGACCCGAGGCCCAGATCCAAGGCCGCGGCCCAGACCCACTCTGCGGCCCGGGCCGACCCTGCGGCCTCCACCA ACCCCGCGGCCCAGACCCAGCCCGCGGCCTGGACCCCTGGACCGCTTTGCGCACTTACCGCCCTGCGGGCCACAGGGCAAAATCGCCATA GGCCAAGGTGCATATAGAAAACAAAGGAGCATTAAGCCCAATCTATGTCGTGTTTTCAAGGAAGAAAACGGAAATGTGTGGTCGAGCTTT TTTGTACCCTGAAGTGTTTTTTTTATTGCCCTAAGTGATTTCCACAGGTTCTGGAATAACTCTTACAGCTTTGCCTTGTGTCCTCCTGTT CCGTGTGGGCTTTAAAAGAAAAAAAATCAAACCCACATATTAAAAGGGGGCTTTTTATCTGCCATCTAATGGCTTCAGAGCGATAATACA CTATTATCTTCTTAAACCAGGAAAAAATAAAAGGGGGGGTGGGATTTTTCAGAAAAATTAAAAAAGAAAGTTTTTGTAGCTGTTCAGTTG CCACTAAGAGATTGCACAGTCAAAACGACTCTAAACACACTAGTTTGGATTCCTAAATATTTTCAAGAAAAGAATCTTCTCGTTTGAAAC TTTGAATTAAAATAAAACACATTTACTCCACATATTTTTTAACAAAAAGAAAACGTCACATCAGGAAACTCTGATTTTGTGGTAGCTGAC ATAGTGTTTTCTTGTACGTGAATAGAATCCTGACATGTAGTGCACATTGATGTATAGCTTTAACTGACCCTGGGTTTTGCAGACCAGGGT TTGTTTAATACACTCCATTCTAGGCCAAATCAGGACAAAAAAAAGAAAAAAAAAGAAAAAAAAAAAAGAAAAGATCCGAATCTAGGTATT TTATAATCTGCTTTTTAACCTCTAACCGCAGAGCACGCTGATCAGACCTCATATCTTGGAGGTTTAGGAGACAAGTTAGAACTGTAGCAT GTACCTGTTAATTTTGTTTAATTTATGGTGTCTCAATCTGTCTGTGCGTCTGCACGTGTGCAAGCATTGAAAGAAAGGAGAGAGTAGTCC GGGCGAGCACAGCAGGCAGTTCCAGGGCCAGACGGGCCCATCCCCAAGTAGATAGCAGTCTACGGATCTCTCTCTGGCACAGAAGGCACC TCACCTCACACCACTCTCCTGGATACCTGATGAACTGAGCCCTCCCAGGGGAAGACACTCCCCAGGCCTGGGCAGGGCTTACACGCGCAC TCTCTCTCTTCTTTCCCTTTTTCTTCCCACCGCAAGCACTGATGACCCTGTTGAACTCGTGGGAAACTTCCTTTCTCTGCAGGAGAGAGA ACGTGGCATTCTGGGCTCCCCACTCCCATCCCTGTAGAAATGGCCCAAACTCACACCAAAACGTGGATGCTCTTCAACTTCCAAACCTAC CATTTGCCCTTCTTTCATTTCGCCTCTTAGTTCTTTTTATGCACAGTTTTAGGGCAGTCTAAGTACAAACTGAAAGTCTAACTTGTCTCT GATTCCTCCCTTGTCTATGTGTATATGCGTGAGAATAGAGGCGGGTGAGAGTGTGCGTGCGTGTGCGTGTGTGCAATTTTATACGTCTGT GTATTTTCTTAAGTACCTGTGCACACGTAGAGTGCATTACTGCCACCTTTTTCAATAAGCTGTTTTATCAGTTACGGCTTCTACAAGTTT GCTAATTTAGACTTCTTTATTGCCATATCTTTAAACTAACAATAGATGATTTCGGTATATATATATATTTTTTTTTGCTTATTTATAGGT GCTGTATTTTATTATCTGATTGTTAGGAAGGGATGAAAGGGGCAAATATTCTTTAGAGGGATAGACTGCCGGCAGTATTGGGTATAATTT ACAAGATGTAGTTGTCATACTGTATATTACTGATTGAAAACTTTTTGACCGTATTGTGTATCATTGAAACCTTTGTCTTAGGTCAACATC TTTGGATGACATTTTAATGGTGCATTCATTATTTCTTAAGTTTAATTAATATTACTTTTTTTTTTATTTGGGGGGTGGGAGGGAGTTATA ATTTTAAAGGTATGCTCTGGCTGTTCCACCTCCGTGTGCTTGTTAATTAACTTGTAGGACTTTGACTGTAAGATGTGAAACCACGTTTCT TGCATGATGTTTTAGAGATTATTTCATTTACAGTCTTTTAACCTGCAGCTGCAGCACTTAGTTCACGTTTTCACAAATTTCAAGAGTCAC TACACTAAAGACAATGCCTTTTCATGAATAAGAAGTTTTCAGAAGGCTCTAGGGGGCTGGGAGGCAGGCTGTTCGTTTGTCTTTTGTTGG GGGTATCATTTCTGAACTTGAAATCCAGTTCAGGGAGAAGAGAATTCAAAATTAGAGGAGCTTAAGGGGACACGGGTCAACATCTAGCTC GATTCAGGTGCATTGAGAAGAGTGAGTTCACATCGGTGACCCTTAGGACAGTGAGTGGCAGAGCCCTGACGACTGTGGTGTCCTCTCCAC AAAACCCTCAAGGGACTTTTGTCATCATGTGTGATGAATCTTTAAATATCGTCTAATTTTCATAAGAATGAAAAGAAGTTAACAGGAAAT AGTAGGCTAGGGTTTAGTTTTAAAGGCATGACTGTTATTTACAAAGGTGTTAAATCTGAGGAAATTGACAAATACAGATTTGTCCATTCT AGTGGCCAAACAGTAACAGTCTAAAATGCAGTCATTTTGACCCTCCCAAGCAATTTAGTCATATGTGTTGTTTTCTCTTTTCTGTTTTTA CTTCTTAGATTTTTAACTAGGTTACTGTTGGTTCCCATTCTGTCTTTTTTGCCAGACTTACATCTGGTGCCAGATACAATCAGTTGGTTA AATTTTGCTTGCAGTTCTGTGTATTTTTTTTCCTCTATTATTTATTTTTTTAAAAAAAATAGAGATCCTAACCTTAGATCTTTGATGTGA AGCTAGCACTGTCTGTAATACTTCTAAGAGCTGCCACTAAAATAATACAGCAATCCGTGGCCAGGGGAGCACCCCCTCCTGGTTGGGCCC CTCAGTTGGAGTCTAAGGGTTAATCTCTCATCTTGCTAAGCAGTATTCAAGTGCCTTGAACAGTGTCCCCTCGGCATGGCTCCCCTTCAG CAGGCTGGCATTCCAAGCAGTGGCCCCCGCAGGCAGCCGACCCCCTTCCTCTTCACGCTCTATGAGTTTAAAAAGCTGATTTGTACCTCT CCCCTGGGGGAAACGGTTCCATATAAAACACTAACACTTAATTACAAGCTCCATTATGCCATTTTAAATGGCTTCTTTTTGTTAATTGGA GGCATTGTTCATAACTTAAGGCTTTTGCCATTAACTTAGCTGGCTAAGCAGAGGCTCGGGGTAAAATCAGTGTTTGCATTTAGCCTCTTG ACCCGGAGTTCCGGCCCAAGCTCCCTTGTGATAGCCGAGATGGCAGGTGTGTGAGTTCTGTCCTAGACCTGTGCCCAACTCACTTCCACC CCAGAGGAGTCTTCTGTCCTCCTCCCCAACCCCCGAGCTCCCTGGTAACCTCCTCTTGAACTTCTGTATCAGTGAAGACATCTGTGGTTT CTGCTCACCAGACCTCTCTTTAGAAAGGGTTATCAGAGCCATGGAGCTTAGCTCAATTGGATTCTTCTAGACGATCTTAGGAGGCATCTT GGCATGAGGCAGCTTCTAAGCGTCTCCTGGGACAGGATTGGGGTGACAGCCCAGGGATGCATGCATGGGAGAACTCTCTGAGAAATGCCA GGATCGTGGCTCACAGGGACCCACCATCAAAACCTGCTACTTTGTGCAAGTAATTGAGGCAAAAGATACCAGTCGACAGCCTCCCTGGGG TAGATCCCTTGTACCTCCAAAGTACAAATACCTCCCTGCTCAGTTTCCTTCCTGTCGCCATCTTTGTTTTCTTCCCATTGAAAAACCATC CTGTCTGATGTGGACGTTCAGGTCTGCTGGTTGGCGGTCCGGGCCCAGAGTGCAGCAGAGCTCTGGGTTAAATATTCCTTTCTGGCCACC GCCCAAGCCCAGGTGGCCAGCTCTCATACCCCATCTCCCTCCTTGGCCAGGGCCAGCATCAGGCGTGCAGCTCATGACCAGTTTACACAG GCTGCAAAGAGATCGCTGTGGGCCTCGGCTGACTACTTTAAGATTATGCCACAGCCAGGCCCTAAAAAGAGAGGGGAACAGGAGTCCCCA GGTGAGCTCTCTGACGGGCAGGTGCCTTCCCGACTAAGGTTGGACTGGATGACTTTGTTCCTCCTGCATGCATGTCCTTTGATGCAAGGG TGATCAATGAACTCTGTTGACATTCTATGCAATGTTTTTCATTCCTCTGATTTTAGCAAAGCAAATCTTACTGAAAAATAGCAGAGCCAG GGGAACAGACGCATGTCCTTCTGGGAGTCACACAAAAGCAGAGAGATTTTGAACTGAGGGGCGACAGCCTTTGCCTTAAATGCAGTATGA CAGGCGCTTCTTGGCAGACCAGTAAAAACAAAAGCCCATAGACCTTACTCATCCCAAGGCCGACAAGCCAGCTGTACAGGGCGAGATGTA GCAACACGGGGCATGAGCGGTGGGCGTGCTGGGCTATTTGCTGTGGTACTTTAGGCTGGAGGTTTGGCTCCTGTGCTGCCGGTGGGGGGC CCTGTCCCTCCCCAGATGTCCTCCCTCTTCTTCACACTCCTCATTGTCCCTTCTACCTCACTAACCTGTCTTCTCCATCTGATGTCACCC AGAACCACACCCCACAGAACTGTGAGGCACGTGGGCTGGAGAGAGCAGAAAAGCTGCCAGCGCAGCAGACACGAACATCCCTCTGCCTGG TGGGCCGGCTTTGTGTGTCTCTCCTTTTGTGAGCGCAACACGGACAAACAGCTGTGCTCTGCAAGGCACACGGATGTTTCCCTTCCACCT GTTCCCAAAGCTCCAGCAGCTGTTTCTTTTGCAGGCAGGGCGTGGTCTCGGGGCTCCGAGGGTCTTGTCTTTGGTCCGCCTTCCTTTCTG TCCAGTCCTGCTCAGCTGTTAAGATCCATCATGGCCATTATCCTTGTCCCGGACTGCCCCAAAGTTCCCAGCTGGCTTTGGGGAACACTG TAGCTCTTGGGTGTCTCTTGTCTCTGGCATGGTTTTAGCGTCACTGCGAACACTCCTTTGCAAACATCAAACATCTCAAAGACGGAAAAG GATAGATGGCTTCCTCCAGCCTACACGCCCCGTCCACAGTGGCATCACCCTCTTATCCCAAAAGAATATGCCAGTTCCCATCCAGCACCG AAGAAAATCAGCTCCTGGGGCTGGTGGTTGGAGGTGGGTCTGTCCACTGTGGGGGCCAAAGTGTTCCCCTGCTGGAGACAGTTTGCAAGT AAGAACCTAAGGATGGGGACAGCATCCTGTGCTTGGGCATTGACCAGCCAAAGCTCACATTTAGAAAGCCCTCAGTGCTTCTGTGGTTTC ACCTGGGCATCGACGACATTAGGGAAGCCTTTGTGACCACAAGGGCAGGGCTTGTGCCCTGAGTGGCGAGGTGGTGACCTGAGGCCAGTG TGATGTGGTTGGATCTCAGCGTGTACTGAATGCCAGTCTGGCCGGCACACTCGAACGCTAAGAGAATGGTCCAATTTGATGATCTTATTT CTATTTCGATCAGGTTTTGACTTTTTGTAGATGAAAACTACCAGGGAAAAGGGGAAGCAGGTACCCAATAAAGTTTAGAAAGATCCAGTC TGTGAAACCCTTAGAGATGGGCTGAAAGTTAAGTCCACCAACCCTTGGGCTTAATCAGGACGGAAGAGGAGGGGGTGTGGGGGGCAGAGC GTAAAACAAGCCCCAGCCCTACTCCCGGCCCCCCAGCCCAGTCTTCCCAATCCCAGAGGCCCCGGCGGCCTGTGCTCCTCACCACCCTGG TCAGGGGAATAGAAGGAAATGCAATTTCCGCCTGTCTGCCCGACTTCCAAAAACTGCCTCCTCCTGCCCAGGCCTCTCCCACCACCACCT TCCCTCCAAAGATAACCGTGTCCATGCCATCCGTGGCATCATCTCGAGTTTTCATTTTTGGATGAAGTGACATTTAGCTTTAACAAGACA TTTCCAAAGCGCCTAGTCTCCTCCAAAATGCTAACTTTAAAAGTTGGGCATTGTAGGCGAAAAATCCCAAAAAAAAAAAAAGACAAAAAA AAAAGGCTGGCGAGAGAAAGACATTTGGCTATGCATAAATGTGCACTTCCCCCATGCCCCCGTTCTTAAACTCTTAAGATGCCTTTGAGT TGCTTTTCATGAATCCTTTTAGTTTACCCGATAATGTTAAGAAAGCATTAGTCTACGTTACTGTAATTTCTGTAGTGTTTACGCTTTAAT TTCTACCACAAAATATGCTATATGCTATGTATCAAGCTTTCTGTAATCAGAAAGAAAAGGTGCCTTATATCCCAATGTCACGGCTACATC CCTATGGAAATTAATCAGAAGCACAGTGTGTACGGAAGCATTGGGACTTCTGCTGGTGAAACAAGAGACCATTCAGCAAGACACATTGAA GTGGCACGGAGCTGCTTTTGTTTTATAATTCTTTTTTCCCCCCTTTTCCTTCTTCTTTTTTATTATTTTATTATTTTTTTTGTACTTTGC TTTAAACGGAAAGCACTTAAATAGATGACTATGTGTAAAAGCTCTGTGCAATTGAAATCATTTTTCTTCATTTTAAAAAAATAACGTATT GCACACCAAATGAACTCAAAGTAAGCTTTAGACCAGGACGATTCAGGTTATGAATGAGTTTGTTCACTGTAGTTCCGTTTGTTCATGAAC CGAAGGGAAAACAGGCCTCCCCGACTCCCTCCAGTCTCCCAGCCTGCCTCTTGGTGACCACTGTGCTGGGCGTGCAGGGCCCGCGGGCTC TGGCCGGAGCCGCTGGCCTGACGAGGCAGGATAGGGAGTATCCGTGATTCAGAAGCTGAGACCCTTCCCCAGTGTCTGAGGCCACAGCCA TCCCTTCCAGCACTTAATCTTGTCTTGTTGAAATGGACTGACTGCTACTGACCTGCCGGCGTGCGTGAGGGTGATTATAAAAGGATGTTT CCTTGAGAAAAAAAAAATTATTTCTATCCTCTTCTATTTATTATTAGGTTAATCATTTAAGTACTTATCAGGAGTGTATTGTTATTTTGT GTTTTGTTGTCATAAATGCTTTTTGCTGTCACTCTAGTGGTTACTATCCTCTGCCTTCCTCTCCTCCCCTACTCCCCCAGAGAACCAAGG CGTCTGGGGGATTGACTGGGGGGCAGAGGGGGTTTCCCCAGCAAAATCAAACACCTGTCTCCAGAGTAGCCACTCAAAAACTGGTGGTCT CTATGTGTCTAACTTTTTAAATGAGAGTGTTTATGAACAAAAAAATTTACCAACGTGTGAGGGAGTTGCTGAGTTGAAGAATGCTCGCTT GAGGAGCTTCAGAGGAATCTTAGCAAAGCCAAGTTCAGTTCCCCAAAGCCTCCTAGAGCCTCTGGTAAGACTTCTGGGTTCATGAAGTTT CGGCGAGCCGTGGTCAGAGAGGGCGCGGTGGCCTGGCCAAGACTTTACCTCCAAGCGAGAGAGTGATTTCTTGCAAGGCCCGCATGGGTT GATACGTTTTGGTTGGTTTTTTGTTGTTGTTTTTCTTGCGTACAAAGTTGGTCAAAACCATCTTTCAAAGCAACAGTGTTTTGTAGTACC AGGCTGTGGCTTGAGGGCTCACCTAGGAGATCATAGGCAGAGGGCCCCTTTCCCCTATAGGTGGTTCAACGTGGAGGAAGGTTGGGTGTG GAGATTGCTTGCTGTGGCCCCAAGCTCAGCCAGCAGGACACCCAGTTGTTGCCAATCAGGTGTGAAGGTGAGGCGCCCTGCCTTGATCCC ATGGGCCCAGCAGAAGGAAACTTACCCCAGGCCAAGGCAAGGGCCCTGCTCACCCCAAGGTAGGCTGGGAAGAGCATCTCTTTCCATATC ATCACCTCCCCTTCTCCAAGATTGCCGGGGGCCCTGATTTTGTTCTCTCTTTGAAAGAAACCCTCCACCGAAACAATGGTCCCCATCTCC CCAGAAGCCTTTTTTTTTTTCATTTTTCTCTAATTAGTCTATGCATTTCTCTCTCTCAAACCATCTTCTGCCTCTTCCCTTGAGAAAACG GGCATCTCACGTACCCCCATCTGAGACCTCTTGGAAAAAAAAAATCCCGTGTATTCTGGAGATGTGAGAATTCACCCAAAATTCTTAAAA CATTGGAGAATAGCTTGTTATAAAATAAAAGTGGGGGTAAAAAGAAGGTGGTTTTCCCCACATCCCTTTGCATTGAATAAGAGACCTAGT TCTTTGCGTTTGTGCAATAACTCTTTGCTGCTTGCCTTGAGAGCGGGTAGCACCACGCTCCTGTCCAGACTACTAACAGCACAAGACGCA CTCACAGGGTGGCGGAATCTTCCGGAAAACTCTCTATAAGCTCAGCTCCCCCCACCCCACCCCCACTCTAGCGTTTTGTCACGTCTTACA TTTTAGCAGTATTTTATATTTTCTGTAACGCACCAAGTCTTAGATCTTTCTAGAGCTTGTTTGTTCATCCTCACAATCACAGATTTTTTT CTCCAATCCTCACAGAGACCCAATTGACCAAAAAAGAAAAAAGGAAAAAAAAAAAGTCGTCTTTTTTTTTTTTTTTTGTACAAATCGCTT TGAGATGCCTCTGGTGTGTTGCTGTGTGACATCTCTCTGGTAACATTTTATTTCTTGCTATTTGTTTTTCTACATTAAGAGTCAAAGTTG ACCTGGCTGGCGTGGGGGTGGGGGAGGCACCCGTCGGCCCCTTGGTGTTGTCCCTCTGTCTTTGGTTAGCCATACGATGTTTGTTCTCAG CACTGTACAACGGTCCCTATATAATACGGAGAAGCAATATCACTGTATGAGACTCACACCATGTATTATTATTCACTAGCACCCTAGGTG >10121_10121_1_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000292535_length(amino acids)=1607AA_BP=327 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLD ALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQ RCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGADEIEMIMTDLERANQRAEVAQREAETLREQLS SANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQ ADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPESRRPGSLPAPPPSQLPRNP GEQASNTNGTHQFSPAGLSQDFFSSSLASPSLPLASTGKFALNSLLQRQLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQQSPD VNGMAPSPSQSESAGSVSEGEEMDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQ NILALRSIQGRQRENPGQSLNRLFQEVPKRRNGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSDDAIRS ILQQARREMEAQQAALDPALKQAPLSQSDITILTPKLLSTSPMPTVSSYPPLAISLKKPSAAPEAGASALPNPPALKKEAQDAPGLDPQG AADCAQGVLRQVKNEVGRSGAWKDHWWSAVQPERRNAASSEEAKAEETGGGKEKGSGGSGGGSQPRAERSQLQGPSSSEYWKEWPSAESP YSQSSELSLTGASRSETPQNSPLPSSPIVPMSKPTKPSVPPLTPEQYEVYMYQEVDTIELTRQVKEKLAKNGICQRIFGEKVLGLSQGSV SDMLSRPKPWSKLTQKGREPFIRMQLWLNGELGQGVLPVQGQQQGPVLHSVTSLQDPLQQGCVSSESTPKTSASCSPAPESPMSSSESVK SLTELVQQPCPPIEASKDSKPPEPSDPPASDSQPTTPLPLSGHSALSIQELVAMSPELDTYGITKRVKEVLTDNNLGQRLFGETILGLTQ GSVSDLLARPKPWHKLSLKGREPFVRMQLWLNDPNNVEKLMDMKRMEKKAYMKRRHSSVSDSQPCEPPSVGTEYSQGASPQPQHQLKKPR VVLAPEEKEALKRAYQQKPYPSPKTIEDLATQLNLKTSTVINWFHNYRSRIRRELFIEEIQAGSQGQAGASDSPSARSGRAAPSSEGDSC DGVEATEGPGSADTEEPKSQGEAEREEVPRPAEQTEPPPSGTPGPDDARDDDHEGGPVEGPGPLPSPASATATAAPAAPEDAATSAAAAP -------------------------------------------------------------- >10121_10121_2_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000292538_length(transcript)=3238nt_BP=1041nt CGCCTCCCTTCCCCCTCCCCGCCCGACAGCGGCCGCTCGGGCCCCGGCTCTCGGTTATAAGATGGCGGCGCTGAGCGGTGGCGGTGGTGG CGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGCGCCGGCGCCGCGGCCTCTTCGGCTGCGGA CCCTGCCATTCCGGAGGAGGTGTGGAATATCAAACAAATGATTAAGTTGACACAGGAACATATAGAGGCCCTATTGGACAAATTTGGTGG GGAGCATAATCCACCATCAATATATCTGGAGGCCTATGAAGAATACACCAGCAAGCTAGATGCACTCCAACAAAGAGAACAACAGTTATT GGAATCTCTGGGGAACGGAACTGATTTTTCTGTTTCTAGCTCTGCATCAATGGATACCGTTACATCTTCTTCCTCTTCTAGCCTTTCAGT GCTACCTTCATCTCTTTCAGTTTTTCAAAATCCCACAGATGTGGCACGGAGCAACCCCAAGTCACCACAAAAACCTATCGTTAGAGTCTT CCTGCCCAACAAACAGAGGACAGTGGTACCTGCAAGGTGTGGAGTTACAGTCCGAGACAGTCTAAAGAAAGCACTGATGATGAGAGGTCT AATCCCAGAGTGCTGTGCTGTTTACAGAATTCAGGATGGAGAGAAGAAACCAATTGGTTGGGACACTGATATTTCCTGGCTTACTGGAGA AGAATTGCATGTGGAAGTGTTGGAGAATGTTCCACTTACAACACACAACTTTGTACGAAAAACGTTTTTCACCTTAGCATTTTGTGACTT TTGTCGAAAGCTGCTTTTCCAGGGTTTCCGCTGTCAAACATGTGGTTATAAATTTCACCAGCGTTGTAGTACAGAAGTTCCACTGATGTG TGTTAATTATGACCAACTTGATTTGCTGTTTGTCTCCAAGTTCTTTGAACACCACCCAATACCACAGGAAGAGGCGTCCTTAGCAGAGAC TGCCCTAACATCTGGATCATCCCCTTCCGCACCCGCCTCGGACTCTATTGGGGCCGACGAGATTGAAATGATCATGACGGACCTTGAAAG GGCAAACCAGAGGGCAGAGGTGGCTCAGAGAGAGGCGGAGACCTTAAGGGAACAGCTCTCATCGGCCAATCACTCCCTCCAGCTGGCCTC ACAGATCCAGAAGGCACCAGACGTGGAGCAGGCCATAGAGGTGCTGACCCGCTCCAGCCTAGAAGTTGAGTTGGCCGCCAAGGAGCGGGA GATCGCACAGCTGGTGGAGGACGTGCAGAGACTCCAGGCCAGCCTCACCAAGCTGCGGGAGAATTCGGCCAGCCAGATCTCACAGCTTGA GCAGCAGCTGAGCGCCAAAAACAGCACACTCAAACAACTGGAAGAAAAACTCAAAGGCCAGGCTGACTATGAAGAGGTGAAGAAAGAGCT GAACATTCTGAAGTCCATGGAGTTTGCACCGTCCGAGGGCGCTGGGACACAGGATGCGGCCAAGCCCCTGGAGGTGCTGTTGCTGGAGAA GAACCGCTCGCTGCAGTCCGAGAACGCCGCGCTGCGCATCTCCAACAGCGACCTGAGCGGACGCTGTGCAGAGCTGCAAGTCCGTATCAC TGAGGCTGTGGCCACAGCCACTGAGCAGAGAGAGCTGATCGCCCGCCTGGAGCAGGACCTGAGCATCATTCAGTCCATCCAGCGGCCCGA TGCCGAGGGTGCCGCTGAGCACCGCCTGGAGAAGATCCCAGAGCCCATCAAAGAGGCCACTGCCCTATTCTACGGACCTGCAGCACCAGC CAGCGGTGCCCTCCCAGAGGGCCAGGTGGATTCACTGCTTTCCATCATCTCCAGCCAGAGGGAGCGCTTCCGTGCCCGGAACCAGGAGCT TGAGGCCGAGAACCGCCTGGCCCAGCACACCCTCCAGGCCCTGCAGAGTGAGCTGGACAGCCTGCGCGCCGACAACATCAAGCTCTTTGA GAAGATCAAGTTCCTGCAGAGCTACCCTGGCCGGGGCAGCGGCAGTGATGACACGGAGCTGCGGTACTCGTCCCAGTACGAGGAGCGCCT GGACCCCTTCTCCTCCTTCAGCAAGCGGGAGCGGCAGAGGAAGTACCTGAGCTTGAGTCCCTGGGACAAGGCCACCCTCAGCATGGGGCG TCTGGTTCTCTCCAACAAGATGGCGCGCACCATCGGCTTCTTCTACACACTGTTCCTGCACTGCCTGGTCTTCCTGGTGCTCTACAAGCT GGCATGGAGCGAGAGCATGGAGAGGGACTGTGCCACCTTCTGCGCCAAGAAGTTCGCTGACCACCTGCACAAGTTCCACGAGAATGACAA CGGGGCTGCGGCTGGTGACTTGTGGCAGTGATACCCCGGGGCCTCCCCCGTGACAGTGACGGCTGCGCCTCCACCCCGACTGCTCAGTGC ATCTAATCACTTAGACTCCCCTGAAGAATCCCCCATGGAAACTGCCCTTATCCGCTGTCCAGCAGCTGCCAGAGGCCCCAGGTCACCTCG GGTCCCCTTGAAAGAATGTCTCGGTCACATCAGGCCCGCTAGGTCCAGAGAGCGAGCCCCCAATGCCCGGCCAGGCTAAGCCGCAGAGAC CCTCTCAGCCCCCACCTCAGGTTAGGGCTCTGCCCGCAGCCTGACCTCTAGCCCTGGTGGCAGAGGTCCCTCAGCTGCGAGGCTAATTGG GTGACCACCGATTCCAGCTGCGGTTAATCCAGCTTGGGCCTGTCTGCACTGCGATCCTCTTGGGCTCTCCTAGGATCCCCCCATGCCCCG TAAGAGGTGGAAGACGCTTCCTTCCAGGACAGCAGGCTTTGAGTCCAGCACCCCCAGCCTGCCTTTGCCACCAGCCCCACCCTGCAGAGT ATATGAGGCTTGACAGAGTCTGCCCCCTCCCCCACTGCACCCCAAGAGAGAGAGCCCCAGCCAGCGGAACAGTTTCTATTACCCCCTCCC TGCCCCCAGACCCATGTGATTTCTGCTTTCTTCTTTAGCAAGATATTCTGGTTTCTAGATAAGGAAGAGTCTCTAATGAGCCCCCGAGCC CCAGTCTCTTCAGACTCATGGATTGGTCTGAGGGGTCTGAACGTCTCCTAGCCAATCAGAACTGGCTGTGGACCACCCTAGCACGGCCAC >10121_10121_2_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000292538_length(amino acids)=769AA_BP=327 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLD ALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQ RCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGADEIEMIMTDLERANQRAEVAQREAETLREQLS SANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQ ADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDL SIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDS LRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMARTIGFFYTLFLH -------------------------------------------------------------- >10121_10121_3_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000360264_length(transcript)=14076nt_BP=1041nt CGCCTCCCTTCCCCCTCCCCGCCCGACAGCGGCCGCTCGGGCCCCGGCTCTCGGTTATAAGATGGCGGCGCTGAGCGGTGGCGGTGGTGG CGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGCGCCGGCGCCGCGGCCTCTTCGGCTGCGGA CCCTGCCATTCCGGAGGAGGTGTGGAATATCAAACAAATGATTAAGTTGACACAGGAACATATAGAGGCCCTATTGGACAAATTTGGTGG GGAGCATAATCCACCATCAATATATCTGGAGGCCTATGAAGAATACACCAGCAAGCTAGATGCACTCCAACAAAGAGAACAACAGTTATT GGAATCTCTGGGGAACGGAACTGATTTTTCTGTTTCTAGCTCTGCATCAATGGATACCGTTACATCTTCTTCCTCTTCTAGCCTTTCAGT GCTACCTTCATCTCTTTCAGTTTTTCAAAATCCCACAGATGTGGCACGGAGCAACCCCAAGTCACCACAAAAACCTATCGTTAGAGTCTT CCTGCCCAACAAACAGAGGACAGTGGTACCTGCAAGGTGTGGAGTTACAGTCCGAGACAGTCTAAAGAAAGCACTGATGATGAGAGGTCT AATCCCAGAGTGCTGTGCTGTTTACAGAATTCAGGATGGAGAGAAGAAACCAATTGGTTGGGACACTGATATTTCCTGGCTTACTGGAGA AGAATTGCATGTGGAAGTGTTGGAGAATGTTCCACTTACAACACACAACTTTGTACGAAAAACGTTTTTCACCTTAGCATTTTGTGACTT TTGTCGAAAGCTGCTTTTCCAGGGTTTCCGCTGTCAAACATGTGGTTATAAATTTCACCAGCGTTGTAGTACAGAAGTTCCACTGATGTG TGTTAATTATGACCAACTTGATTTGCTGTTTGTCTCCAAGTTCTTTGAACACCACCCAATACCACAGGAAGAGGCGTCCTTAGCAGAGAC TGCCCTAACATCTGGATCATCCCCTTCCGCACCCGCCTCGGACTCTATTGGGGCCGACGAGATTGAAATGATCATGACGGACCTTGAAAG GGCAAACCAGAGGGCAGAGGTGGCTCAGAGAGAGGCGGAGACCTTAAGGGAACAGCTCTCATCGGCCAATCACTCCCTCCAGCTGGCCTC ACAGATCCAGAAGGCACCAGACGTGGAGCAGGCCATAGAGGTGCTGACCCGCTCCAGCCTAGAAGTTGAGTTGGCCGCCAAGGAGCGGGA GATCGCACAGCTGGTGGAGGACGTGCAGAGACTCCAGGCCAGCCTCACCAAGCTGCGGGAGAATTCGGCCAGCCAGATCTCACAGCTTGA GCAGCAGCTGAGCGCCAAAAACAGCACACTCAAACAACTGGAAGAAAAACTCAAAGGCCAGGCTGACTATGAAGAGGTGAAGAAAGAGCT GAACATTCTGAAGTCCATGGAGTTTGCACCGTCCGAGGGCGCTGGGACACAGGATGCGGCCAAGCCCCTGGAGGTGCTGTTGCTGGAGAA GAACCGCTCGCTGCAGTCCGAGAACGCCGCGCTGCGCATCTCCAACAGCGACCTGAGCGGGTCAGCCAGGAGGAAAGGGAAAGACCAGCC TGAAAGTCGGCGCCCGGGATCTTTGCCGGCCCCCCCTCCTTCTCAGTTGCCCCGCAACCCGGGGGAGCAGGCTTCCAATACTAATGGTAC ACACCAGTTCTCACCAGCGGGGTTAAGTCAAGACTTTTTCAGCTCATCCCTGGCAAGCCCCAGCCTACCCCTGGCTTCTACAGGAAAATT TGCACTAAACTCTCTTCTCCAGCGGCAGCTAATGCAGTCCTTCTACTCCAAGGCTATGCAGGAAGCCGGAAGCACAAGCATGATTTTTTC AACAGGTCCATACAGCACAAACTCCATATCTTCCCAAAGTCCATTACAACAAAGCCCAGATGTCAATGGCATGGCCCCATCCCCCAGCCA GTCAGAAAGTGCTGGGAGCGTCTCCGAGGGCGAGGAGATGGACACTGCAGAAATCGCCCGGCAGGTCAAAGAGCAGCTGATTAAGCACAA TATCGGACAACGTATTTTCGGACATTATGTGTTGGGACTGTCTCAAGGGTCCGTGAGCGAGATTCTGGCCCGGCCCAAGCCATGGAATAA ACTGACTGTTCGTGGCAAGGAGCCATTTCACAAGATGAAACAGTTCCTCTCCGATGAGCAGAACATCCTGGCCCTCCGTAGCATCCAAGG CAGACAAAGAGAGAATCCAGGCCAGAGCCTGAACAGACTATTTCAGGAAGTACCGAAACGAAGAAATGGGTCTGAAGGTAACATCACCAC CCGGATCCGAGCCTCGGAGACTGGCTCTGATGAAGCCATCAAGTCCATCCTAGAGCAAGCCAAGAGGGAGCTCCAAGTGCAGAAAACTGC AGAGCCGGCCCAGCCTTCCTCCGCATCCGGCAGCGGGAACTCTGATGACGCCATCCGCTCCATCCTGCAGCAAGCCCGCCGGGAGATGGA GGCCCAGCAGGCTGCCCTCGACCCTGCCTTAAAGCAGGCACCACTGTCCCAGAGTGACATCACCATCCTCACCCCCAAGCTTCTGTCCAC CTCGCCCATGCCCACCGTGTCCAGCTACCCACCTCTCGCCATCTCCCTGAAGAAGCCCTCCGCAGCTCCTGAGGCCGGTGCCTCTGCTCT GCCGAACCCCCCGGCCCTCAAAAAGGAGGCCCAGGACGCCCCCGGGCTGGACCCCCAGGGAGCAGCCGATTGTGCACAAGGGGTCCTGAG ACAGGTGAAAAATGAGGTGGGCCGCAGCGGTGCCTGGAAGGACCACTGGTGGAGCGCGGTGCAGCCGGAGAGAAGAAATGCCGCCTCCTC CGAGGAGGCCAAGGCCGAAGAAACGGGCGGCGGGAAAGAGAAGGGCAGCGGTGGCAGCGGAGGTGGCAGCCAGCCTCGGGCCGAGCGCAG TCAGCTCCAGGGACCCTCGTCGTCAGAGTACTGGAAGGAGTGGCCCAGCGCTGAGTCCCCATACTCCCAGAGCTCAGAGCTGAGTCTGAC CGGGGCCAGCCGCAGCGAGACACCACAGAACAGCCCCCTGCCATCCTCCCCGATCGTGCCCATGTCCAAGCCCACCAAGCCCTCGGTCCC CCCGCTGACCCCCGAGCAGTACGAGGTCTACATGTACCAGGAGGTGGACACCATCGAGCTCACCCGGCAGGTTAAGGAAAAGCTGGCCAA GAACGGCATCTGCCAGAGAATCTTCGGGGAGAAGGTGCTGGGCCTGTCCCAGGGCAGCGTCAGCGACATGCTGTCCCGACCGAAGCCATG GAGCAAGCTGACGCAGAAAGGCCGAGAACCCTTCATCCGGATGCAGCTCTGGCTGAACGGCGAGCTAGGCCAGGGTGTTCTACCCGTCCA GGGCCAGCAGCAAGGGCCAGTCCTCCACTCCGTGACATCGCTCCAGGACCCGCTGCAGCAGGGCTGTGTGAGCTCAGAAAGCACTCCAAA GACCTCCGCCAGCTGCAGCCCTGCCCCTGAGTCCCCGATGAGTTCCAGTGAGTCGGTGAAGAGCCTGACCGAGCTGGTCCAGCAGCCCTG TCCCCCCATCGAGGCGAGCAAGGACAGCAAGCCACCAGAGCCCAGTGACCCGCCAGCATCCGACTCCCAGCCCACAACCCCGCTGCCTCT CTCCGGACACTCGGCCCTCAGCATCCAAGAATTAGTAGCCATGTCCCCGGAGCTGGACACCTACGGCATAACCAAGCGGGTGAAGGAGGT GCTGACGGACAACAACCTCGGCCAGCGCTTATTTGGGGAGACCATCTTAGGGCTCACCCAAGGCTCTGTCTCTGACCTCCTTGCCCGCCC CAAACCCTGGCATAAGCTCAGTCTGAAAGGACGAGAGCCCTTCGTCCGGATGCAGCTGTGGCTGAACGACCCCAACAATGTGGAGAAGCT GATGGACATGAAACGGATGGAGAAGAAAGCCTACATGAAGCGGCGGCACAGCTCAGTCAGTGACAGCCAGCCCTGCGAACCGCCCTCTGT CGGCACCGAGTACAGCCAGGGCGCCAGCCCCCAGCCCCAGCACCAGCTGAAGAAACCCCGGGTGGTGCTGGCTCCGGAGGAGAAGGAGGC GCTGAAACGAGCGTATCAGCAAAAGCCATACCCGTCACCAAAAACCATCGAAGACCTCGCCACCCAGCTCAACCTGAAAACCAGCACCGT CATCAACTGGTTCCACAACTACAGGTCTCGGATCCGCAGAGAACTGTTCATTGAGGAAATTCAGGCCGGGAGTCAGGGCCAGGCGGGCGC CAGCGACTCACCCTCGGCCCGCAGCGGCCGGGCGGCGCCCAGCTCGGAGGGCGACAGCTGCGACGGCGTGGAGGCCACTGAGGGCCCAGG CAGCGCCGACACCGAGGAGCCCAAGTCTCAGGGAGAGGCCGAGCGGGAGGAGGTGCCGCGGCCGGCGGAGCAGACGGAGCCGCCGCCCTC GGGGACCCCGGGCCCGGACGACGCCCGCGACGACGACCACGAGGGAGGCCCCGTGGAAGGCCCGGGGCCCCTGCCCAGCCCCGCCTCCGC GACCGCCACCGCCGCGCCCGCGGCCCCCGAGGACGCCGCTACCTCAGCCGCCGCCGCGCCGGGGGAGGGCCCCGCGGCCCCGAGCTCCGC GCCGCCGCCCAGCAACAGCAGCAGCAGCAGCGCCCCCCGCAGGCCCAGCTCGCTGCAGAGCCTTTTCGGCCTCCCCGAGGCCGCGGGCGC CCGGGACTCGCGCGACAACCCCCTGCGCAAGAAGAAGGCCGCGAACTTGAACAGCATCATCCACCGCCTGGAGAAGGCCGCCAGCCGGGA GGAACCTATCGAATGGGAGTTCTGAGGGGCCGCGGCCCTGGGGCGGGCAGCCAGGCTGGGCCGCAAGGGCCTGGACGGGGTCGGACGGGG CAGGCGCTGCGGACACCGTGGCCTGGGCTTGGCCCGCGGCCTGCACCGACCCCGGGCCGGACCTGAGCCCGCAGCCCAGACCCCCTCCAC GGTCCGCGGCCTGCACCGACCCGAGGCCCAGATCCAAGGCCGCGGCCCAGACCCACTCTGCGGCCCGGGCCGACCCTGCGGCCTCCACCA ACCCCGCGGCCCAGACCCAGCCCGCGGCCTGGACCCCTGGACCGCTTTGCGCACTTACCGCCCTGCGGGCCACAGGGCAAAATCGCCATA GGCCAAGGTGCATATAGAAAACAAAGGAGCATTAAGCCCAATCTATGTCGTGTTTTCAAGGAAGAAAACGGAAATGTGTGGTCGAGCTTT TTTGTACCCTGAAGTGTTTTTTTTATTGCCCTAAGTGATTTCCACAGGTTCTGGAATAACTCTTACAGCTTTGCCTTGTGTCCTCCTGTT CCGTGTGGGCTTTAAAAGAAAAAAAATCAAACCCACATATTAAAAGGGGGCTTTTTATCTGCCATCTAATGGCTTCAGAGCGATAATACA CTATTATCTTCTTAAACCAGGAAAAAATAAAAGGGGGGGTGGGATTTTTCAGAAAAATTAAAAAAGAAAGTTTTTGTAGCTGTTCAGTTG CCACTAAGAGATTGCACAGTCAAAACGACTCTAAACACACTAGTTTGGATTCCTAAATATTTTCAAGAAAAGAATCTTCTCGTTTGAAAC TTTGAATTAAAATAAAACACATTTACTCCACATATTTTTTAACAAAAAGAAAACGTCACATCAGGAAACTCTGATTTTGTGGTAGCTGAC ATAGTGTTTTCTTGTACGTGAATAGAATCCTGACATGTAGTGCACATTGATGTATAGCTTTAACTGACCCTGGGTTTTGCAGACCAGGGT TTGTTTAATACACTCCATTCTAGGCCAAATCAGGACAAAAAAAAGAAAAAAAAAGAAAAAAAAAAAAGAAAAGATCCGAATCTAGGTATT TTATAATCTGCTTTTTAACCTCTAACCGCAGAGCACGCTGATCAGACCTCATATCTTGGAGGTTTAGGAGACAAGTTAGAACTGTAGCAT GTACCTGTTAATTTTGTTTAATTTATGGTGTCTCAATCTGTCTGTGCGTCTGCACGTGTGCAAGCATTGAAAGAAAGGAGAGAGTAGTCC GGGCGAGCACAGCAGGCAGTTCCAGGGCCAGACGGGCCCATCCCCAAGTAGATAGCAGTCTACGGATCTCTCTCTGGCACAGAAGGCACC TCACCTCACACCACTCTCCTGGATACCTGATGAACTGAGCCCTCCCAGGGGAAGACACTCCCCAGGCCTGGGCAGGGCTTACACGCGCAC TCTCTCTCTTCTTTCCCTTTTTCTTCCCACCGCAAGCACTGATGACCCTGTTGAACTCGTGGGAAACTTCCTTTCTCTGCAGGAGAGAGA ACGTGGCATTCTGGGCTCCCCACTCCCATCCCTGTAGAAATGGCCCAAACTCACACCAAAACGTGGATGCTCTTCAACTTCCAAACCTAC CATTTGCCCTTCTTTCATTTCGCCTCTTAGTTCTTTTTATGCACAGTTTTAGGGCAGTCTAAGTACAAACTGAAAGTCTAACTTGTCTCT GATTCCTCCCTTGTCTATGTGTATATGCGTGAGAATAGAGGCGGGTGAGAGTGTGCGTGCGTGTGCGTGTGTGCAATTTTATACGTCTGT GTATTTTCTTAAGTACCTGTGCACACGTAGAGTGCATTACTGCCACCTTTTTCAATAAGCTGTTTTATCAGTTACGGCTTCTACAAGTTT GCTAATTTAGACTTCTTTATTGCCATATCTTTAAACTAACAATAGATGATTTCGGTATATATATATATTTTTTTTTGCTTATTTATAGGT GCTGTATTTTATTATCTGATTGTTAGGAAGGGATGAAAGGGGCAAATATTCTTTAGAGGGATAGACTGCCGGCAGTATTGGGTATAATTT ACAAGATGTAGTTGTCATACTGTATATTACTGATTGAAAACTTTTTGACCGTATTGTGTATCATTGAAACCTTTGTCTTAGGTCAACATC TTTGGATGACATTTTAATGGTGCATTCATTATTTCTTAAGTTTAATTAATATTACTTTTTTTTTTATTTGGGGGGTGGGAGGGAGTTATA ATTTTAAAGGTATGCTCTGGCTGTTCCACCTCCGTGTGCTTGTTAATTAACTTGTAGGACTTTGACTGTAAGATGTGAAACCACGTTTCT TGCATGATGTTTTAGAGATTATTTCATTTACAGTCTTTTAACCTGCAGCTGCAGCACTTAGTTCACGTTTTCACAAATTTCAAGAGTCAC TACACTAAAGACAATGCCTTTTCATGAATAAGAAGTTTTCAGAAGGCTCTAGGGGGCTGGGAGGCAGGCTGTTCGTTTGTCTTTTGTTGG GGGTATCATTTCTGAACTTGAAATCCAGTTCAGGGAGAAGAGAATTCAAAATTAGAGGAGCTTAAGGGGACACGGGTCAACATCTAGCTC GATTCAGGTGCATTGAGAAGAGTGAGTTCACATCGGTGACCCTTAGGACAGTGAGTGGCAGAGCCCTGACGACTGTGGTGTCCTCTCCAC AAAACCCTCAAGGGACTTTTGTCATCATGTGTGATGAATCTTTAAATATCGTCTAATTTTCATAAGAATGAAAAGAAGTTAACAGGAAAT AGTAGGCTAGGGTTTAGTTTTAAAGGCATGACTGTTATTTACAAAGGTGTTAAATCTGAGGAAATTGACAAATACAGATTTGTCCATTCT AGTGGCCAAACAGTAACAGTCTAAAATGCAGTCATTTTGACCCTCCCAAGCAATTTAGTCATATGTGTTGTTTTCTCTTTTCTGTTTTTA CTTCTTAGATTTTTAACTAGGTTACTGTTGGTTCCCATTCTGTCTTTTTTGCCAGACTTACATCTGGTGCCAGATACAATCAGTTGGTTA AATTTTGCTTGCAGTTCTGTGTATTTTTTTTCCTCTATTATTTATTTTTTTAAAAAAAATAGAGATCCTAACCTTAGATCTTTGATGTGA AGCTAGCACTGTCTGTAATACTTCTAAGAGCTGCCACTAAAATAATACAGCAATCCGTGGCCAGGGGAGCACCCCCTCCTGGTTGGGCCC CTCAGTTGGAGTCTAAGGGTTAATCTCTCATCTTGCTAAGCAGTATTCAAGTGCCTTGAACAGTGTCCCCTCGGCATGGCTCCCCTTCAG CAGGCTGGCATTCCAAGCAGTGGCCCCCGCAGGCAGCCGACCCCCTTCCTCTTCACGCTCTATGAGTTTAAAAAGCTGATTTGTACCTCT CCCCTGGGGGAAACGGTTCCATATAAAACACTAACACTTAATTACAAGCTCCATTATGCCATTTTAAATGGCTTCTTTTTGTTAATTGGA GGCATTGTTCATAACTTAAGGCTTTTGCCATTAACTTAGCTGGCTAAGCAGAGGCTCGGGGTAAAATCAGTGTTTGCATTTAGCCTCTTG ACCCGGAGTTCCGGCCCAAGCTCCCTTGTGATAGCCGAGATGGCAGGTGTGTGAGTTCTGTCCTAGACCTGTGCCCAACTCACTTCCACC CCAGAGGAGTCTTCTGTCCTCCTCCCCAACCCCCGAGCTCCCTGGTAACCTCCTCTTGAACTTCTGTATCAGTGAAGACATCTGTGGTTT CTGCTCACCAGACCTCTCTTTAGAAAGGGTTATCAGAGCCATGGAGCTTAGCTCAATTGGATTCTTCTAGACGATCTTAGGAGGCATCTT GGCATGAGGCAGCTTCTAAGCGTCTCCTGGGACAGGATTGGGGTGACAGCCCAGGGATGCATGCATGGGAGAACTCTCTGAGAAATGCCA GGATCGTGGCTCACAGGGACCCACCATCAAAACCTGCTACTTTGTGCAAGTAATTGAGGCAAAAGATACCAGTCGACAGCCTCCCTGGGG TAGATCCCTTGTACCTCCAAAGTACAAATACCTCCCTGCTCAGTTTCCTTCCTGTCGCCATCTTTGTTTTCTTCCCATTGAAAAACCATC CTGTCTGATGTGGACGTTCAGGTCTGCTGGTTGGCGGTCCGGGCCCAGAGTGCAGCAGAGCTCTGGGTTAAATATTCCTTTCTGGCCACC GCCCAAGCCCAGGTGGCCAGCTCTCATACCCCATCTCCCTCCTTGGCCAGGGCCAGCATCAGGCGTGCAGCTCATGACCAGTTTACACAG GCTGCAAAGAGATCGCTGTGGGCCTCGGCTGACTACTTTAAGATTATGCCACAGCCAGGCCCTAAAAAGAGAGGGGAACAGGAGTCCCCA GGTGAGCTCTCTGACGGGCAGGTGCCTTCCCGACTAAGGTTGGACTGGATGACTTTGTTCCTCCTGCATGCATGTCCTTTGATGCAAGGG TGATCAATGAACTCTGTTGACATTCTATGCAATGTTTTTCATTCCTCTGATTTTAGCAAAGCAAATCTTACTGAAAAATAGCAGAGCCAG GGGAACAGACGCATGTCCTTCTGGGAGTCACACAAAAGCAGAGAGATTTTGAACTGAGGGGCGACAGCCTTTGCCTTAAATGCAGTATGA CAGGCGCTTCTTGGCAGACCAGTAAAAACAAAAGCCCATAGACCTTACTCATCCCAAGGCCGACAAGCCAGCTGTACAGGGCGAGATGTA GCAACACGGGGCATGAGCGGTGGGCGTGCTGGGCTATTTGCTGTGGTACTTTAGGCTGGAGGTTTGGCTCCTGTGCTGCCGGTGGGGGGC CCTGTCCCTCCCCAGATGTCCTCCCTCTTCTTCACACTCCTCATTGTCCCTTCTACCTCACTAACCTGTCTTCTCCATCTGATGTCACCC AGAACCACACCCCACAGAACTGTGAGGCACGTGGGCTGGAGAGAGCAGAAAAGCTGCCAGCGCAGCAGACACGAACATCCCTCTGCCTGG TGGGCCGGCTTTGTGTGTCTCTCCTTTTGTGAGCGCAACACGGACAAACAGCTGTGCTCTGCAAGGCACACGGATGTTTCCCTTCCACCT GTTCCCAAAGCTCCAGCAGCTGTTTCTTTTGCAGGCAGGGCGTGGTCTCGGGGCTCCGAGGGTCTTGTCTTTGGTCCGCCTTCCTTTCTG TCCAGTCCTGCTCAGCTGTTAAGATCCATCATGGCCATTATCCTTGTCCCGGACTGCCCCAAAGTTCCCAGCTGGCTTTGGGGAACACTG TAGCTCTTGGGTGTCTCTTGTCTCTGGCATGGTTTTAGCGTCACTGCGAACACTCCTTTGCAAACATCAAACATCTCAAAGACGGAAAAG GATAGATGGCTTCCTCCAGCCTACACGCCCCGTCCACAGTGGCATCACCCTCTTATCCCAAAAGAATATGCCAGTTCCCATCCAGCACCG AAGAAAATCAGCTCCTGGGGCTGGTGGTTGGAGGTGGGTCTGTCCACTGTGGGGGCCAAAGTGTTCCCCTGCTGGAGACAGTTTGCAAGT AAGAACCTAAGGATGGGGACAGCATCCTGTGCTTGGGCATTGACCAGCCAAAGCTCACATTTAGAAAGCCCTCAGTGCTTCTGTGGTTTC ACCTGGGCATCGACGACATTAGGGAAGCCTTTGTGACCACAAGGGCAGGGCTTGTGCCCTGAGTGGCGAGGTGGTGACCTGAGGCCAGTG TGATGTGGTTGGATCTCAGCGTGTACTGAATGCCAGTCTGGCCGGCACACTCGAACGCTAAGAGAATGGTCCAATTTGATGATCTTATTT CTATTTCGATCAGGTTTTGACTTTTTGTAGATGAAAACTACCAGGGAAAAGGGGAAGCAGGTACCCAATAAAGTTTAGAAAGATCCAGTC TGTGAAACCCTTAGAGATGGGCTGAAAGTTAAGTCCACCAACCCTTGGGCTTAATCAGGACGGAAGAGGAGGGGGTGTGGGGGGCAGAGC GTAAAACAAGCCCCAGCCCTACTCCCGGCCCCCCAGCCCAGTCTTCCCAATCCCAGAGGCCCCGGCGGCCTGTGCTCCTCACCACCCTGG TCAGGGGAATAGAAGGAAATGCAATTTCCGCCTGTCTGCCCGACTTCCAAAAACTGCCTCCTCCTGCCCAGGCCTCTCCCACCACCACCT TCCCTCCAAAGATAACCGTGTCCATGCCATCCGTGGCATCATCTCGAGTTTTCATTTTTGGATGAAGTGACATTTAGCTTTAACAAGACA TTTCCAAAGCGCCTAGTCTCCTCCAAAATGCTAACTTTAAAAGTTGGGCATTGTAGGCGAAAAATCCCAAAAAAAAAAAAAGACAAAAAA AAAAGGCTGGCGAGAGAAAGACATTTGGCTATGCATAAATGTGCACTTCCCCCATGCCCCCGTTCTTAAACTCTTAAGATGCCTTTGAGT TGCTTTTCATGAATCCTTTTAGTTTACCCGATAATGTTAAGAAAGCATTAGTCTACGTTACTGTAATTTCTGTAGTGTTTACGCTTTAAT TTCTACCACAAAATATGCTATATGCTATGTATCAAGCTTTCTGTAATCAGAAAGAAAAGGTGCCTTATATCCCAATGTCACGGCTACATC CCTATGGAAATTAATCAGAAGCACAGTGTGTACGGAAGCATTGGGACTTCTGCTGGTGAAACAAGAGACCATTCAGCAAGACACATTGAA GTGGCACGGAGCTGCTTTTGTTTTATAATTCTTTTTTCCCCCCTTTTCCTTCTTCTTTTTTATTATTTTATTATTTTTTTTGTACTTTGC TTTAAACGGAAAGCACTTAAATAGATGACTATGTGTAAAAGCTCTGTGCAATTGAAATCATTTTTCTTCATTTTAAAAAAATAACGTATT GCACACCAAATGAACTCAAAGTAAGCTTTAGACCAGGACGATTCAGGTTATGAATGAGTTTGTTCACTGTAGTTCCGTTTGTTCATGAAC CGAAGGGAAAACAGGCCTCCCCGACTCCCTCCAGTCTCCCAGCCTGCCTCTTGGTGACCACTGTGCTGGGCGTGCAGGGCCCGCGGGCTC TGGCCGGAGCCGCTGGCCTGACGAGGCAGGATAGGGAGTATCCGTGATTCAGAAGCTGAGACCCTTCCCCAGTGTCTGAGGCCACAGCCA TCCCTTCCAGCACTTAATCTTGTCTTGTTGAAATGGACTGACTGCTACTGACCTGCCGGCGTGCGTGAGGGTGATTATAAAAGGATGTTT CCTTGAGAAAAAAAAAATTATTTCTATCCTCTTCTATTTATTATTAGGTTAATCATTTAAGTACTTATCAGGAGTGTATTGTTATTTTGT GTTTTGTTGTCATAAATGCTTTTTGCTGTCACTCTAGTGGTTACTATCCTCTGCCTTCCTCTCCTCCCCTACTCCCCCAGAGAACCAAGG CGTCTGGGGGATTGACTGGGGGGCAGAGGGGGTTTCCCCAGCAAAATCAAACACCTGTCTCCAGAGTAGCCACTCAAAAACTGGTGGTCT CTATGTGTCTAACTTTTTAAATGAGAGTGTTTATGAACAAAAAAATTTACCAACGTGTGAGGGAGTTGCTGAGTTGAAGAATGCTCGCTT GAGGAGCTTCAGAGGAATCTTAGCAAAGCCAAGTTCAGTTCCCCAAAGCCTCCTAGAGCCTCTGGTAAGACTTCTGGGTTCATGAAGTTT CGGCGAGCCGTGGTCAGAGAGGGCGCGGTGGCCTGGCCAAGACTTTACCTCCAAGCGAGAGAGTGATTTCTTGCAAGGCCCGCATGGGTT GATACGTTTTGGTTGGTTTTTTGTTGTTGTTTTTCTTGCGTACAAAGTTGGTCAAAACCATCTTTCAAAGCAACAGTGTTTTGTAGTACC AGGCTGTGGCTTGAGGGCTCACCTAGGAGATCATAGGCAGAGGGCCCCTTTCCCCTATAGGTGGTTCAACGTGGAGGAAGGTTGGGTGTG GAGATTGCTTGCTGTGGCCCCAAGCTCAGCCAGCAGGACACCCAGTTGTTGCCAATCAGGTGTGAAGGTGAGGCGCCCTGCCTTGATCCC ATGGGCCCAGCAGAAGGAAACTTACCCCAGGCCAAGGCAAGGGCCCTGCTCACCCCAAGGTAGGCTGGGAAGAGCATCTCTTTCCATATC ATCACCTCCCCTTCTCCAAGATTGCCGGGGGCCCTGATTTTGTTCTCTCTTTGAAAGAAACCCTCCACCGAAACAATGGTCCCCATCTCC CCAGAAGCCTTTTTTTTTTTCATTTTTCTCTAATTAGTCTATGCATTTCTCTCTCTCAAACCATCTTCTGCCTCTTCCCTTGAGAAAACG GGCATCTCACGTACCCCCATCTGAGACCTCTTGGAAAAAAAAAATCCCGTGTATTCTGGAGATGTGAGAATTCACCCAAAATTCTTAAAA CATTGGAGAATAGCTTGTTATAAAATAAAAGTGGGGGTAAAAAGAAGGTGGTTTTCCCCACATCCCTTTGCATTGAATAAGAGACCTAGT TCTTTGCGTTTGTGCAATAACTCTTTGCTGCTTGCCTTGAGAGCGGGTAGCACCACGCTCCTGTCCAGACTACTAACAGCACAAGACGCA CTCACAGGGTGGCGGAATCTTCCGGAAAACTCTCTATAAGCTCAGCTCCCCCCACCCCACCCCCACTCTAGCGTTTTGTCACGTCTTACA TTTTAGCAGTATTTTATATTTTCTGTAACGCACCAAGTCTTAGATCTTTCTAGAGCTTGTTTGTTCATCCTCACAATCACAGATTTTTTT CTCCAATCCTCACAGAGACCCAATTGACCAAAAAAGAAAAAAGGAAAAAAAAAAAGTCGTCTTTTTTTTTTTTTTTTGTACAAATCGCTT TGAGATGCCTCTGGTGTGTTGCTGTGTGACATCTCTCTGGTAACATTTTATTTCTTGCTATTTGTTTTTCTACATTAAGAGTCAAAGTTG ACCTGGCTGGCGTGGGGGTGGGGGAGGCACCCGTCGGCCCCTTGGTGTTGTCCCTCTGTCTTTGGTTAGCCATACGATGTTTGTTCTCAG CACTGTACAACGGTCCCTATATAATACGGAGAAGCAATATCACTGTATGAGACTCACACCATGTATTATTATTCACTAGCACCCTAGGTG >10121_10121_3_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000360264_length(amino acids)=1607AA_BP=327 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLD ALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQ RCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGADEIEMIMTDLERANQRAEVAQREAETLREQLS SANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQ ADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPESRRPGSLPAPPPSQLPRNP GEQASNTNGTHQFSPAGLSQDFFSSSLASPSLPLASTGKFALNSLLQRQLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQQSPD VNGMAPSPSQSESAGSVSEGEEMDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQ NILALRSIQGRQRENPGQSLNRLFQEVPKRRNGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSDDAIRS ILQQARREMEAQQAALDPALKQAPLSQSDITILTPKLLSTSPMPTVSSYPPLAISLKKPSAAPEAGASALPNPPALKKEAQDAPGLDPQG AADCAQGVLRQVKNEVGRSGAWKDHWWSAVQPERRNAASSEEAKAEETGGGKEKGSGGSGGGSQPRAERSQLQGPSSSEYWKEWPSAESP YSQSSELSLTGASRSETPQNSPLPSSPIVPMSKPTKPSVPPLTPEQYEVYMYQEVDTIELTRQVKEKLAKNGICQRIFGEKVLGLSQGSV SDMLSRPKPWSKLTQKGREPFIRMQLWLNGELGQGVLPVQGQQQGPVLHSVTSLQDPLQQGCVSSESTPKTSASCSPAPESPMSSSESVK SLTELVQQPCPPIEASKDSKPPEPSDPPASDSQPTTPLPLSGHSALSIQELVAMSPELDTYGITKRVKEVLTDNNLGQRLFGETILGLTQ GSVSDLLARPKPWHKLSLKGREPFVRMQLWLNDPNNVEKLMDMKRMEKKAYMKRRHSSVSDSQPCEPPSVGTEYSQGASPQPQHQLKKPR VVLAPEEKEALKRAYQQKPYPSPKTIEDLATQLNLKTSTVINWFHNYRSRIRRELFIEEIQAGSQGQAGASDSPSARSGRAAPSSEGDSC DGVEATEGPGSADTEEPKSQGEAEREEVPRPAEQTEPPPSGTPGPDDARDDDHEGGPVEGPGPLPSPASATATAAPAAPEDAATSAAAAP -------------------------------------------------------------- >10121_10121_4_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000393824_length(transcript)=2753nt_BP=1041nt CGCCTCCCTTCCCCCTCCCCGCCCGACAGCGGCCGCTCGGGCCCCGGCTCTCGGTTATAAGATGGCGGCGCTGAGCGGTGGCGGTGGTGG CGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGCGCCGGCGCCGCGGCCTCTTCGGCTGCGGA CCCTGCCATTCCGGAGGAGGTGTGGAATATCAAACAAATGATTAAGTTGACACAGGAACATATAGAGGCCCTATTGGACAAATTTGGTGG GGAGCATAATCCACCATCAATATATCTGGAGGCCTATGAAGAATACACCAGCAAGCTAGATGCACTCCAACAAAGAGAACAACAGTTATT GGAATCTCTGGGGAACGGAACTGATTTTTCTGTTTCTAGCTCTGCATCAATGGATACCGTTACATCTTCTTCCTCTTCTAGCCTTTCAGT GCTACCTTCATCTCTTTCAGTTTTTCAAAATCCCACAGATGTGGCACGGAGCAACCCCAAGTCACCACAAAAACCTATCGTTAGAGTCTT CCTGCCCAACAAACAGAGGACAGTGGTACCTGCAAGGTGTGGAGTTACAGTCCGAGACAGTCTAAAGAAAGCACTGATGATGAGAGGTCT AATCCCAGAGTGCTGTGCTGTTTACAGAATTCAGGATGGAGAGAAGAAACCAATTGGTTGGGACACTGATATTTCCTGGCTTACTGGAGA AGAATTGCATGTGGAAGTGTTGGAGAATGTTCCACTTACAACACACAACTTTGTACGAAAAACGTTTTTCACCTTAGCATTTTGTGACTT TTGTCGAAAGCTGCTTTTCCAGGGTTTCCGCTGTCAAACATGTGGTTATAAATTTCACCAGCGTTGTAGTACAGAAGTTCCACTGATGTG TGTTAATTATGACCAACTTGATTTGCTGTTTGTCTCCAAGTTCTTTGAACACCACCCAATACCACAGGAAGAGGCGTCCTTAGCAGAGAC TGCCCTAACATCTGGATCATCCCCTTCCGCACCCGCCTCGGACTCTATTGGGGCCGACGAGATTGAAATGATCATGACGGACCTTGAAAG GGCAAACCAGAGGGCAGAGGTGGCTCAGAGAGAGGCGGAGACCTTAAGGGAACAGCTCTCATCGGCCAATCACTCCCTCCAGCTGGCCTC ACAGATCCAGAAGGCACCAGACGTGGCCATAGAGGTGCTGACCCGCTCCAGCCTAGAAGTTGAGTTGGCCGCCAAGGAGCGGGAGATCGC ACAGCTGGTGGAGGACGTGCAGAGACTCCAGGCCAGCCTCACCAAGCTGCGGGAGAATTCGGCCAGCCAGATCTCACAGCTTGAGCAGCA GCTGAGCGCCAAAAACAGCACACTCAAACAACTGGAAGAAAAACTCAAAGGCCAGGCTGACTATGAAGAGGTGAAGAAAGAGCTGAACAT TCTGAAGTCCATGGAGTTTGCACCGTCCGAGGGCGCTGGGACACAGGATGCGGCCAAGCCCCTGGAGGTGCTGTTGCTGGAGAAGAACCG CTCGCTGCAGTCCGAGAACGCCGCGCTGCGCATCTCCAACAGCGACCTGAGCGGACGCTGTGCAGAGCTGCAAGTCCGTATCACTGAGGC TGTGGCCACAGCCACTGAGCAGAGAGAGCTGATCGCCCGCCTGGAGCAGGACCTGAGCATCATTCAGTCCATCCAGCGGCCCGATGCCGA GGGTGCCGCTGAGCACCGCCTGGAGAAGATCCCAGAGCCCATCAAAGAGGCCACTGCCCTATTCTACGGACCTGCAGCACCAGCCAGCGG TGCCCTCCCAGAGGGCCAGGTGGATTCACTGCTTTCCATCATCTCCAGCCAGAGGGAGCGCTTCCGTGCCCGGAACCAGGAGCTTGAGGC CGAGAACCGCCTGGCCCAGCACACCCTCCAGGCCCTGCAGAGTGAGCTGGACAGCCTGCGCGCCGACAACATCAAGCTCTTTGAGAAGAT CAAGTTCCTGCAGAGCTACCCTGGCCGGGGCAGCGGCAGTGATGACACGGAGCTGCGGTACTCGTCCCAGTACGAGGAGCGCCTGGACCC CTTCTCCTCCTTCAGCAAGCGGGAGCGGCAGAGGAAGTACCTGAGCTTGAGTCCCTGGGACAAGGCCACCCTCAGCATGGGGCGTCTGGT TCTCTCCAACAAGATGGCGCGCACCATCGGCTTCTTCTACACACTGTTCCTGCACTGCCTGGTCTTCCTGGTGCTCTACAAGCTGGCATG GAGCGAGAGCATGGAGAGGGACTGTGCCACCTTCTGCGCCAAGAAGTTCGCTGACCACCTGCACAAGTTCCACGAGAATGACAACGGGGC TGCGGCTGGTGACTTGTGGCAGTGATACCCCGGGGCCTCCCCCGTGACAGTGACGGCTGCGCCTCCACCCCGACTGCTCAGTGCATCTAA TCACTTAGACTCCCCTGAAGAATCCCCCATGGAAACTGCCCTTATCCGCTGTCCAGCAGCTGCCAGAGGCCCCAGGTCACCTCGGGTCCC CTTGAAAGAATGTCTCGGTCACATCAGGCCCGCTAGGTCCAGAGAGCGAGCCCCCAATGCCCGGCCAGGCTAAGCCGCAGAGACCCTCTC AGCCCCCACCTCAGGTTAGGGCTCTGCCCGCAGCCTGACCTCTAGCCCTGGTGGCAGAGGTCCCTCAGCTGCGAGGCTAATTGGGTGACC >10121_10121_4_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000393824_length(amino acids)=767AA_BP=327 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLD ALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQ RCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGADEIEMIMTDLERANQRAEVAQREAETLREQLS SANHSLQLASQIQKAPDVAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQAD YEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSI IQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLR ADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMARTIGFFYTLFLHCL -------------------------------------------------------------- >10121_10121_5_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000425244_length(transcript)=3238nt_BP=1041nt CGCCTCCCTTCCCCCTCCCCGCCCGACAGCGGCCGCTCGGGCCCCGGCTCTCGGTTATAAGATGGCGGCGCTGAGCGGTGGCGGTGGTGG CGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGCGCCGGCGCCGCGGCCTCTTCGGCTGCGGA CCCTGCCATTCCGGAGGAGGTGTGGAATATCAAACAAATGATTAAGTTGACACAGGAACATATAGAGGCCCTATTGGACAAATTTGGTGG GGAGCATAATCCACCATCAATATATCTGGAGGCCTATGAAGAATACACCAGCAAGCTAGATGCACTCCAACAAAGAGAACAACAGTTATT GGAATCTCTGGGGAACGGAACTGATTTTTCTGTTTCTAGCTCTGCATCAATGGATACCGTTACATCTTCTTCCTCTTCTAGCCTTTCAGT GCTACCTTCATCTCTTTCAGTTTTTCAAAATCCCACAGATGTGGCACGGAGCAACCCCAAGTCACCACAAAAACCTATCGTTAGAGTCTT CCTGCCCAACAAACAGAGGACAGTGGTACCTGCAAGGTGTGGAGTTACAGTCCGAGACAGTCTAAAGAAAGCACTGATGATGAGAGGTCT AATCCCAGAGTGCTGTGCTGTTTACAGAATTCAGGATGGAGAGAAGAAACCAATTGGTTGGGACACTGATATTTCCTGGCTTACTGGAGA AGAATTGCATGTGGAAGTGTTGGAGAATGTTCCACTTACAACACACAACTTTGTACGAAAAACGTTTTTCACCTTAGCATTTTGTGACTT TTGTCGAAAGCTGCTTTTCCAGGGTTTCCGCTGTCAAACATGTGGTTATAAATTTCACCAGCGTTGTAGTACAGAAGTTCCACTGATGTG TGTTAATTATGACCAACTTGATTTGCTGTTTGTCTCCAAGTTCTTTGAACACCACCCAATACCACAGGAAGAGGCGTCCTTAGCAGAGAC TGCCCTAACATCTGGATCATCCCCTTCCGCACCCGCCTCGGACTCTATTGGGGCCGACGAGATTGAAATGATCATGACGGACCTTGAAAG GGCAAACCAGAGGGCAGAGGTGGCTCAGAGAGAGGCGGAGACCTTAAGGGAACAGCTCTCATCGGCCAATCACTCCCTCCAGCTGGCCTC ACAGATCCAGAAGGCACCAGACGTGGAGCAGGCCATAGAGGTGCTGACCCGCTCCAGCCTAGAAGTTGAGTTGGCCGCCAAGGAGCGGGA GATCGCACAGCTGGTGGAGGACGTGCAGAGACTCCAGGCCAGCCTCACCAAGCTGCGGGAGAATTCGGCCAGCCAGATCTCACAGCTTGA GCAGCAGCTGAGCGCCAAAAACAGCACACTCAAACAACTGGAAGAAAAACTCAAAGGCCAGGCTGACTATGAAGAGGTGAAGAAAGAGCT GAACATTCTGAAGTCCATGGAGTTTGCACCGTCCGAGGGCGCTGGGACACAGGATGCGGCCAAGCCCCTGGAGGTGCTGTTGCTGGAGAA GAACCGCTCGCTGCAGTCCGAGAACGCCGCGCTGCGCATCTCCAACAGCGACCTGAGCGGACGCTGTGCAGAGCTGCAAGTCCGTATCAC TGAGGCTGTGGCCACAGCCACTGAGCAGAGAGAGCTGATCGCCCGCCTGGAGCAGGACCTGAGCATCATTCAGTCCATCCAGCGGCCCGA TGCCGAGGGTGCCGCTGAGCACCGCCTGGAGAAGATCCCAGAGCCCATCAAAGAGGCCACTGCCCTATTCTACGGACCTGCAGCACCAGC CAGCGGTGCCCTCCCAGAGGGCCAGGTGGATTCACTGCTTTCCATCATCTCCAGCCAGAGGGAGCGCTTCCGTGCCCGGAACCAGGAGCT TGAGGCCGAGAACCGCCTGGCCCAGCACACCCTCCAGGCCCTGCAGAGTGAGCTGGACAGCCTGCGCGCCGACAACATCAAGCTCTTTGA GAAGATCAAGTTCCTGCAGAGCTACCCTGGCCGGGGCAGCGGCAGTGATGACACGGAGCTGCGGTACTCGTCCCAGTACGAGGAGCGCCT GGACCCCTTCTCCTCCTTCAGCAAGCGGGAGCGGCAGAGGAAGTACCTGAGCTTGAGTCCCTGGGACAAGGCCACCCTCAGCATGGGGCG TCTGGTTCTCTCCAACAAGATGGCGCGCACCATCGGCTTCTTCTACACACTGTTCCTGCACTGCCTGGTCTTCCTGGTGCTCTACAAGCT GGCATGGAGCGAGAGCATGGAGAGGGACTGTGCCACCTTCTGCGCCAAGAAGTTCGCTGACCACCTGCACAAGTTCCACGAGAATGACAA CGGGGCTGCGGCTGGTGACTTGTGGCAGTGATACCCCGGGGCCTCCCCCGTGACAGTGACGGCTGCGCCTCCACCCCGACTGCTCAGTGC ATCTAATCACTTAGACTCCCCTGAAGAATCCCCCATGGAAACTGCCCTTATCCGCTGTCCAGCAGCTGCCAGAGGCCCCAGGTCACCTCG GGTCCCCTTGAAAGAATGTCTCGGTCACATCAGGCCCGCTAGGTCCAGAGAGCGAGCCCCCAATGCCCGGCCAGGCTAAGCCGCAGAGAC CCTCTCAGCCCCCACCTCAGGTTAGGGCTCTGCCCGCAGCCTGACCTCTAGCCCTGGTGGCAGAGGTCCCTCAGCTGCGAGGCTAATTGG GTGACCACCGATTCCAGCTGCGGTTAATCCAGCTTGGGCCTGTCTGCACTGCGATCCTCTTGGGCTCTCCTAGGATCCCCCCATGCCCCG TAAGAGGTGGAAGACGCTTCCTTCCAGGACAGCAGGCTTTGAGTCCAGCACCCCCAGCCTGCCTTTGCCACCAGCCCCACCCTGCAGAGT ATATGAGGCTTGACAGAGTCTGCCCCCTCCCCCACTGCACCCCAAGAGAGAGAGCCCCAGCCAGCGGAACAGTTTCTATTACCCCCTCCC TGCCCCCAGACCCATGTGATTTCTGCTTTCTTCTTTAGCAAGATATTCTGGTTTCTAGATAAGGAAGAGTCTCTAATGAGCCCCCGAGCC CCAGTCTCTTCAGACTCATGGATTGGTCTGAGGGGTCTGAACGTCTCCTAGCCAATCAGAACTGGCTGTGGACCACCCTAGCACGGCCAC >10121_10121_5_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000425244_length(amino acids)=769AA_BP=327 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLD ALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQ RCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGADEIEMIMTDLERANQRAEVAQREAETLREQLS SANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQ ADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDL SIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDS LRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMARTIGFFYTLFLH -------------------------------------------------------------- >10121_10121_6_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000437600_length(transcript)=3232nt_BP=1041nt CGCCTCCCTTCCCCCTCCCCGCCCGACAGCGGCCGCTCGGGCCCCGGCTCTCGGTTATAAGATGGCGGCGCTGAGCGGTGGCGGTGGTGG CGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGCGCCGGCGCCGCGGCCTCTTCGGCTGCGGA CCCTGCCATTCCGGAGGAGGTGTGGAATATCAAACAAATGATTAAGTTGACACAGGAACATATAGAGGCCCTATTGGACAAATTTGGTGG GGAGCATAATCCACCATCAATATATCTGGAGGCCTATGAAGAATACACCAGCAAGCTAGATGCACTCCAACAAAGAGAACAACAGTTATT GGAATCTCTGGGGAACGGAACTGATTTTTCTGTTTCTAGCTCTGCATCAATGGATACCGTTACATCTTCTTCCTCTTCTAGCCTTTCAGT GCTACCTTCATCTCTTTCAGTTTTTCAAAATCCCACAGATGTGGCACGGAGCAACCCCAAGTCACCACAAAAACCTATCGTTAGAGTCTT CCTGCCCAACAAACAGAGGACAGTGGTACCTGCAAGGTGTGGAGTTACAGTCCGAGACAGTCTAAAGAAAGCACTGATGATGAGAGGTCT AATCCCAGAGTGCTGTGCTGTTTACAGAATTCAGGATGGAGAGAAGAAACCAATTGGTTGGGACACTGATATTTCCTGGCTTACTGGAGA AGAATTGCATGTGGAAGTGTTGGAGAATGTTCCACTTACAACACACAACTTTGTACGAAAAACGTTTTTCACCTTAGCATTTTGTGACTT TTGTCGAAAGCTGCTTTTCCAGGGTTTCCGCTGTCAAACATGTGGTTATAAATTTCACCAGCGTTGTAGTACAGAAGTTCCACTGATGTG TGTTAATTATGACCAACTTGATTTGCTGTTTGTCTCCAAGTTCTTTGAACACCACCCAATACCACAGGAAGAGGCGTCCTTAGCAGAGAC TGCCCTAACATCTGGATCATCCCCTTCCGCACCCGCCTCGGACTCTATTGGGGCCGACGAGATTGAAATGATCATGACGGACCTTGAAAG GGCAAACCAGAGGGCAGAGGTGGCTCAGAGAGAGGCGGAGACCTTAAGGGAACAGCTCTCATCGGCCAATCACTCCCTCCAGCTGGCCTC ACAGATCCAGAAGGCACCAGACGTGGCCATAGAGGTGCTGACCCGCTCCAGCCTAGAAGTTGAGTTGGCCGCCAAGGAGCGGGAGATCGC ACAGCTGGTGGAGGACGTGCAGAGACTCCAGGCCAGCCTCACCAAGCTGCGGGAGAATTCGGCCAGCCAGATCTCACAGCTTGAGCAGCA GCTGAGCGCCAAAAACAGCACACTCAAACAACTGGAAGAAAAACTCAAAGGCCAGGCTGACTATGAAGAGGTGAAGAAAGAGCTGAACAT TCTGAAGTCCATGGAGTTTGCACCGTCCGAGGGCGCTGGGACACAGGATGCGGCCAAGCCCCTGGAGGTGCTGTTGCTGGAGAAGAACCG CTCGCTGCAGTCCGAGAACGCCGCGCTGCGCATCTCCAACAGCGACCTGAGCGGACGCTGTGCAGAGCTGCAAGTCCGTATCACTGAGGC TGTGGCCACAGCCACTGAGCAGAGAGAGCTGATCGCCCGCCTGGAGCAGGACCTGAGCATCATTCAGTCCATCCAGCGGCCCGATGCCGA GGGTGCCGCTGAGCACCGCCTGGAGAAGATCCCAGAGCCCATCAAAGAGGCCACTGCCCTATTCTACGGACCTGCAGCACCAGCCAGCGG TGCCCTCCCAGAGGGCCAGGTGGATTCACTGCTTTCCATCATCTCCAGCCAGAGGGAGCGCTTCCGTGCCCGGAACCAGGAGCTTGAGGC CGAGAACCGCCTGGCCCAGCACACCCTCCAGGCCCTGCAGAGTGAGCTGGACAGCCTGCGCGCCGACAACATCAAGCTCTTTGAGAAGAT CAAGTTCCTGCAGAGCTACCCTGGCCGGGGCAGCGGCAGTGATGACACGGAGCTGCGGTACTCGTCCCAGTACGAGGAGCGCCTGGACCC CTTCTCCTCCTTCAGCAAGCGGGAGCGGCAGAGGAAGTACCTGAGCTTGAGTCCCTGGGACAAGGCCACCCTCAGCATGGGGCGTCTGGT TCTCTCCAACAAGATGGCGCGCACCATCGGCTTCTTCTACACACTGTTCCTGCACTGCCTGGTCTTCCTGGTGCTCTACAAGCTGGCATG GAGCGAGAGCATGGAGAGGGACTGTGCCACCTTCTGCGCCAAGAAGTTCGCTGACCACCTGCACAAGTTCCACGAGAATGACAACGGGGC TGCGGCTGGTGACTTGTGGCAGTGATACCCCGGGGCCTCCCCCGTGACAGTGACGGCTGCGCCTCCACCCCGACTGCTCAGTGCATCTAA TCACTTAGACTCCCCTGAAGAATCCCCCATGGAAACTGCCCTTATCCGCTGTCCAGCAGCTGCCAGAGGCCCCAGGTCACCTCGGGTCCC CTTGAAAGAATGTCTCGGTCACATCAGGCCCGCTAGGTCCAGAGAGCGAGCCCCCAATGCCCGGCCAGGCTAAGCCGCAGAGACCCTCTC AGCCCCCACCTCAGGTTAGGGCTCTGCCCGCAGCCTGACCTCTAGCCCTGGTGGCAGAGGTCCCTCAGCTGCGAGGCTAATTGGGTGACC ACCGATTCCAGCTGCGGTTAATCCAGCTTGGGCCTGTCTGCACTGCGATCCTCTTGGGCTCTCCTAGGATCCCCCCATGCCCCGTAAGAG GTGGAAGACGCTTCCTTCCAGGACAGCAGGCTTTGAGTCCAGCACCCCCAGCCTGCCTTTGCCACCAGCCCCACCCTGCAGAGTATATGA GGCTTGACAGAGTCTGCCCCCTCCCCCACTGCACCCCAAGAGAGAGAGCCCCAGCCAGCGGAACAGTTTCTATTACCCCCTCCCTGCCCC CAGACCCATGTGATTTCTGCTTTCTTCTTTAGCAAGATATTCTGGTTTCTAGATAAGGAAGAGTCTCTAATGAGCCCCCGAGCCCCAGTC TCTTCAGACTCATGGATTGGTCTGAGGGGTCTGAACGTCTCCTAGCCAATCAGAACTGGCTGTGGACCACCCTAGCACGGCCACCTCTCA >10121_10121_6_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000437600_length(amino acids)=767AA_BP=327 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLD ALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQ RCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGADEIEMIMTDLERANQRAEVAQREAETLREQLS SANHSLQLASQIQKAPDVAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQAD YEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSI IQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLR ADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMARTIGFFYTLFLHCL -------------------------------------------------------------- >10121_10121_7_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000546411_length(transcript)=4579nt_BP=1041nt CGCCTCCCTTCCCCCTCCCCGCCCGACAGCGGCCGCTCGGGCCCCGGCTCTCGGTTATAAGATGGCGGCGCTGAGCGGTGGCGGTGGTGG CGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGCGCCGGCGCCGCGGCCTCTTCGGCTGCGGA CCCTGCCATTCCGGAGGAGGTGTGGAATATCAAACAAATGATTAAGTTGACACAGGAACATATAGAGGCCCTATTGGACAAATTTGGTGG GGAGCATAATCCACCATCAATATATCTGGAGGCCTATGAAGAATACACCAGCAAGCTAGATGCACTCCAACAAAGAGAACAACAGTTATT GGAATCTCTGGGGAACGGAACTGATTTTTCTGTTTCTAGCTCTGCATCAATGGATACCGTTACATCTTCTTCCTCTTCTAGCCTTTCAGT GCTACCTTCATCTCTTTCAGTTTTTCAAAATCCCACAGATGTGGCACGGAGCAACCCCAAGTCACCACAAAAACCTATCGTTAGAGTCTT CCTGCCCAACAAACAGAGGACAGTGGTACCTGCAAGGTGTGGAGTTACAGTCCGAGACAGTCTAAAGAAAGCACTGATGATGAGAGGTCT AATCCCAGAGTGCTGTGCTGTTTACAGAATTCAGGATGGAGAGAAGAAACCAATTGGTTGGGACACTGATATTTCCTGGCTTACTGGAGA AGAATTGCATGTGGAAGTGTTGGAGAATGTTCCACTTACAACACACAACTTTGTACGAAAAACGTTTTTCACCTTAGCATTTTGTGACTT TTGTCGAAAGCTGCTTTTCCAGGGTTTCCGCTGTCAAACATGTGGTTATAAATTTCACCAGCGTTGTAGTACAGAAGTTCCACTGATGTG TGTTAATTATGACCAACTTGATTTGCTGTTTGTCTCCAAGTTCTTTGAACACCACCCAATACCACAGGAAGAGGCGTCCTTAGCAGAGAC TGCCCTAACATCTGGATCATCCCCTTCCGCACCCGCCTCGGACTCTATTGGGGCCGACGAGATTGAAATGATCATGACGGACCTTGAAAG GGCAAACCAGAGGGCAGAGGTGGCTCAGAGAGAGGCGGAGACCTTAAGGGAACAGCTCTCATCGGCCAATCACTCCCTCCAGCTGGCCTC ACAGATCCAGAAGGCACCAGACGTGGAGCAGGCCATAGAGGTGCTGACCCGCTCCAGCCTAGAAGTTGAGTTGGCCGCCAAGGAGCGGGA GATCGCACAGCTGGTGGAGGACGTGCAGAGACTCCAGGCCAGCCTCACCAAGCTGCGGGAGAATTCGGCCAGCCAGATCTCACAGCTTGA GCAGCAGCTGAGCGCCAAAAACAGCACACTCAAACAACTGGAAGAAAAACTCAAAGGCCAGGCTGACTATGAAGAGGTGAAGAAAGAGCT GAACATTCTGAAGTCCATGGAGTTTGCACCGTCCGAGGGCGCTGGGACACAGGATGCGGCCAAGCCCCTGGAGGTGCTGTTGCTGGAGAA GAACCGCTCGCTGCAGTCCGAGAACGCCGCGCTGCGCATCTCCAACAGCGACCTGAGCGGTCCATACAGCACAAACTCCATATCTTCCCA AAGTCCATTACAACAAAGCCCAGATGTCAATGGCATGGCCCCATCCCCCAGCCAGTCAGAAAGTGCTGGGAGCGTCTCCGAGGGCGAGGA GATGGACACTGCAGAAATCGCCCGGCAGGTCAAAGAGCAGCTGATTAAGCACAATATCGGACAACGTATTTTCGGACATTATGTGTTGGG ACTGTCTCAAGGGTCCGTGAGCGAGATTCTGGCCCGGCCCAAGCCATGGAATAAACTGACTGTTCGTGGCAAGGAGCCATTTCACAAGAT GAAACAGTTCCTCTCCGATGAGCAGAACATCCTGGCCCTCCGTAGCATCCAAGGCAGACAAAGAGAGAATCCAGGCCAGAGCCTGAACAG ACTATTTCAGGAAGTACCGAAACGAAGAAATGGGTCTGAAGGTAACATCACCACCCGGATCCGAGCCTCGGAGACTGGCTCTGATGAAGC CATCAAGTCCATCCTAGAGCAAGCCAAGAGGGAGCTCCAAGTGCAGAAAACTGCAGAGCCGGCCCAGCCTTCCTCCGCATCCGGCAGCGG GAACTCTGATGACGCCATCCGCTCCATCCTGCAGCAAGCCCGCCGGGAGATGGAGGCCCAGCAGGCTGCCCTCGACCCTGCCTTAAAGCA GGCACCACTGTCCCAGAGTGACATCACCATCCTCACCCCCAAGCTTCTGTCCACCTCGCCCATGCCCACCGTGTCCAGCTACCCACCTCT CGCCATCTCCCTGAAGAAGCCCTCCGCAGCTCCTGAGGCCGGTGCCTCTGCTCTGCCGAACCCCCCGGCCCTCAAAAAGGAGGCCCAGGA CGCCCCCGGGCTGGACCCCCAGGGAGCAGCCGATTGTGCACAAGGGGTCCTGAGACAGGTGAAAAATGAGGTGGGCCGCAGCGGTGCCTG GAAGGACCACTGGTGGAGCGCGGTGCAGCCGGAGAGAAGAAATGCCGCCTCCTCCGAGGAGGCCAAGGCCGAAGAAACGGGCGGCGGGAA AGAGAAGGGCAGCGGTGGCAGCGGAGGTGGCAGCCAGCCTCGGGCCGAGCGCAGTCAGCTCCAGGGACCCTCGTCGTCAGAGTACTGGAA GGAGTGGCCCAGCGCTGAGTCCCCATACTCCCAGAGCTCAGAGCTGAGTCTGACCGGGGCCAGCCGCAGCGAGACACCACAGAACAGCCC CCTGCCATCCTCCCCGATCGTGCCCATGTCCAAGCCCACCAAGCCCTCGGTCCCCCCGCTGACCCCCGAGCAGTACGAGGTCTACATGTA CCAGGAGGTGGACACCATCGAGCTCACCCGGCAGGTTAAGGAAAAGCTGGCCAAGAACGGCATCTGCCAGAGAATCTTCGGGGAGAAGGT GCTGGGCCTGTCCCAGGGCAGCGTCAGCGACATGCTGTCCCGACCGAAGCCATGGAGCAAGCTGACGCAGAAAGGCCGAGAACCCTTCAT CCGGATGCAGCTCTGGCTGAACGGCGAGCTAGGCCAGGGTGTTCTACCCGTCCAGGGCCAGCAGCAAGGGCCAGTCCTCCACTCCGTGAC ATCGCTCCAGGACCCGCTGCAGCAGGGCTGTGTGAGCTCAGAAAGCACTCCAAAGACCTCCGCCAGCTGCAGCCCTGCCCCTGAGTCCCC GATGAGTTCCAGTGAGTCGGTGAAGAGCCTGACCGAGCTGGTCCAGCAGCCCTGTCCCCCCATCGAGGCGAGCAAGGACAGCAAGCCACC AGAGCCCAGTGACCCGCCAGCATCCGACTCCCAGCCCACAACCCCGCTGCCTCTCTCCGGACACTCGGCCCTCAGCATCCAAGAATTAGT AGCCATGTCCCCGGAGCTGGACACCTACGGCATAACCAAGCGGGTGAAGGAGGTGCTGACGGACAACAACCTCGGCCAGCGCTTATTTGG GGAGACCATCTTAGGGCTCACCCAAGGCTCTGTCTCTGACCTCCTTGCCCGCCCCAAACCCTGGCATAAGCTCAGTCTGAAAGGACGAGA GCCCTTCGTCCGGATGCAGCTGTGGCTGAACGACCCCAACAATGTGGAGAAGCTGATGGACATGAAACGGATGGAGAAGAAAGCCTACAT GAAGCGGCGGCACAGCTCAGTCAGTGACAGCCAGCCCTGCGAACCGCCCTCTGTCGGCACCGAGTACAGCCAGGGCGCCAGCCCCCAGCC CCAGCACCAGCTGAAGAAACCCCGGGTGGTGCTGGCTCCGGAGGAGAAGGAGGCGCTGAAACGAGCGTATCAGCAAAAGCCATACCCGTC ACCAAAAACCATCGAAGACCTCGCCACCCAGCTCAACCTGAAAACCAGCACCGTCATCAACTGGTTCCACAACTACAGGTCTCGGATCCG CAGAGAACTGTTCATTGAGGAAATTCAGGCCGGGAGTCAGGGCCAGGCGGGCGCCAGCGACTCACCCTCGGCCCGCAGCGGCCGGGCGGC GCCCAGCTCGGAGGGCGACAGCTGCGACGGCGTGGAGGCCACTGAGGGCCCAGGCAGCGCCGACACCGAGGAGCCCAAGTCTCAGGGAGA GGCCGAGCGGGAGGAGGTGCCGCGGCCGGCGGAGCAGACGGAGCCGCCGCCCTCGGGGACCCCGGGCCCGGACGACGCCCGCGACGACGA CCACGAGGGAGGCCCCGTGGAAGGCCCGGGGCCCCTGCCCAGCCCCGCCTCCGCGACCGCCACCGCCGCGCCCGCGGCCCCCGAGGACGC CGCTACCTCAGCCGCCGCCGCGCCGGGGGAGGGCCCCGCGGCCCCGAGCTCCGCGCCGCCGCCCAGCAACAGCAGCAGCAGCAGCGCCCC CCGCAGGCCCAGCTCGCTGCAGAGCCTTTTCGGCCTCCCCGAGGCCGCGGGCGCCCGGGACTCGCGCGACAACCCCCTGCGCAAGAAGAA >10121_10121_7_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000546411_length(amino acids)=1506AA_BP=327 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLD ALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQ RCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGADEIEMIMTDLERANQRAEVAQREAETLREQLS SANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQ ADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGPYSTNSISSQSPLQQSPDVNGMAPSPSQSE SAGSVSEGEEMDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQ RENPGQSLNRLFQEVPKRRNGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSDDAIRSILQQARREMEAQ QAALDPALKQAPLSQSDITILTPKLLSTSPMPTVSSYPPLAISLKKPSAAPEAGASALPNPPALKKEAQDAPGLDPQGAADCAQGVLRQV KNEVGRSGAWKDHWWSAVQPERRNAASSEEAKAEETGGGKEKGSGGSGGGSQPRAERSQLQGPSSSEYWKEWPSAESPYSQSSELSLTGA SRSETPQNSPLPSSPIVPMSKPTKPSVPPLTPEQYEVYMYQEVDTIELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSK LTQKGREPFIRMQLWLNGELGQGVLPVQGQQQGPVLHSVTSLQDPLQQGCVSSESTPKTSASCSPAPESPMSSSESVKSLTELVQQPCPP IEASKDSKPPEPSDPPASDSQPTTPLPLSGHSALSIQELVAMSPELDTYGITKRVKEVLTDNNLGQRLFGETILGLTQGSVSDLLARPKP WHKLSLKGREPFVRMQLWLNDPNNVEKLMDMKRMEKKAYMKRRHSSVSDSQPCEPPSVGTEYSQGASPQPQHQLKKPRVVLAPEEKEALK RAYQQKPYPSPKTIEDLATQLNLKTSTVINWFHNYRSRIRRELFIEEIQAGSQGQAGASDSPSARSGRAAPSSEGDSCDGVEATEGPGSA DTEEPKSQGEAEREEVPRPAEQTEPPPSGTPGPDDARDDDHEGGPVEGPGPLPSPASATATAAPAAPEDAATSAAAAPGEGPAAPSSAPP -------------------------------------------------------------- >10121_10121_8_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000547394_length(transcript)=3238nt_BP=1041nt CGCCTCCCTTCCCCCTCCCCGCCCGACAGCGGCCGCTCGGGCCCCGGCTCTCGGTTATAAGATGGCGGCGCTGAGCGGTGGCGGTGGTGG CGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGCGCCGGCGCCGCGGCCTCTTCGGCTGCGGA CCCTGCCATTCCGGAGGAGGTGTGGAATATCAAACAAATGATTAAGTTGACACAGGAACATATAGAGGCCCTATTGGACAAATTTGGTGG GGAGCATAATCCACCATCAATATATCTGGAGGCCTATGAAGAATACACCAGCAAGCTAGATGCACTCCAACAAAGAGAACAACAGTTATT GGAATCTCTGGGGAACGGAACTGATTTTTCTGTTTCTAGCTCTGCATCAATGGATACCGTTACATCTTCTTCCTCTTCTAGCCTTTCAGT GCTACCTTCATCTCTTTCAGTTTTTCAAAATCCCACAGATGTGGCACGGAGCAACCCCAAGTCACCACAAAAACCTATCGTTAGAGTCTT CCTGCCCAACAAACAGAGGACAGTGGTACCTGCAAGGTGTGGAGTTACAGTCCGAGACAGTCTAAAGAAAGCACTGATGATGAGAGGTCT AATCCCAGAGTGCTGTGCTGTTTACAGAATTCAGGATGGAGAGAAGAAACCAATTGGTTGGGACACTGATATTTCCTGGCTTACTGGAGA AGAATTGCATGTGGAAGTGTTGGAGAATGTTCCACTTACAACACACAACTTTGTACGAAAAACGTTTTTCACCTTAGCATTTTGTGACTT TTGTCGAAAGCTGCTTTTCCAGGGTTTCCGCTGTCAAACATGTGGTTATAAATTTCACCAGCGTTGTAGTACAGAAGTTCCACTGATGTG TGTTAATTATGACCAACTTGATTTGCTGTTTGTCTCCAAGTTCTTTGAACACCACCCAATACCACAGGAAGAGGCGTCCTTAGCAGAGAC TGCCCTAACATCTGGATCATCCCCTTCCGCACCCGCCTCGGACTCTATTGGGGCCGACGAGATTGAAATGATCATGACGGACCTTGAAAG GGCAAACCAGAGGGCAGAGGTGGCTCAGAGAGAGGCGGAGACCTTAAGGGAACAGCTCTCATCGGCCAATCACTCCCTCCAGCTGGCCTC ACAGATCCAGAAGGCACCAGACGTGGAGCAGGCCATAGAGGTGCTGACCCGCTCCAGCCTAGAAGTTGAGTTGGCCGCCAAGGAGCGGGA GATCGCACAGCTGGTGGAGGACGTGCAGAGACTCCAGGCCAGCCTCACCAAGCTGCGGGAGAATTCGGCCAGCCAGATCTCACAGCTTGA GCAGCAGCTGAGCGCCAAAAACAGCACACTCAAACAACTGGAAGAAAAACTCAAAGGCCAGGCTGACTATGAAGAGGTGAAGAAAGAGCT GAACATTCTGAAGTCCATGGAGTTTGCACCGTCCGAGGGCGCTGGGACACAGGATGCGGCCAAGCCCCTGGAGGTGCTGTTGCTGGAGAA GAACCGCTCGCTGCAGTCCGAGAACGCCGCGCTGCGCATCTCCAACAGCGACCTGAGCGGACGCTGTGCAGAGCTGCAAGTCCGTATCAC TGAGGCTGTGGCCACAGCCACTGAGCAGAGAGAGCTGATCGCCCGCCTGGAGCAGGACCTGAGCATCATTCAGTCCATCCAGCGGCCCGA TGCCGAGGGTGCCGCTGAGCACCGCCTGGAGAAGATCCCAGAGCCCATCAAAGAGGCCACTGCCCTATTCTACGGACCTGCAGCACCAGC CAGCGGTGCCCTCCCAGAGGGCCAGGTGGATTCACTGCTTTCCATCATCTCCAGCCAGAGGGAGCGCTTCCGTGCCCGGAACCAGGAGCT TGAGGCCGAGAACCGCCTGGCCCAGCACACCCTCCAGGCCCTGCAGAGTGAGCTGGACAGCCTGCGCGCCGACAACATCAAGCTCTTTGA GAAGATCAAGTTCCTGCAGAGCTACCCTGGCCGGGGCAGCGGCAGTGATGACACGGAGCTGCGGTACTCGTCCCAGTACGAGGAGCGCCT GGACCCCTTCTCCTCCTTCAGCAAGCGGGAGCGGCAGAGGAAGTACCTGAGCTTGAGTCCCTGGGACAAGGCCACCCTCAGCATGGGGCG TCTGGTTCTCTCCAACAAGATGGCGCGCACCATCGGCTTCTTCTACACACTGTTCCTGCACTGCCTGGTCTTCCTGGTGCTCTACAAGCT GGCATGGAGCGAGAGCATGGAGAGGGACTGTGCCACCTTCTGCGCCAAGAAGTTCGCTGACCACCTGCACAAGTTCCACGAGAATGACAA CGGGGCTGCGGCTGGTGACTTGTGGCAGTGATACCCCGGGGCCTCCCCCGTGACAGTGACGGCTGCGCCTCCACCCCGACTGCTCAGTGC ATCTAATCACTTAGACTCCCCTGAAGAATCCCCCATGGAAACTGCCCTTATCCGCTGTCCAGCAGCTGCCAGAGGCCCCAGGTCACCTCG GGTCCCCTTGAAAGAATGTCTCGGTCACATCAGGCCCGCTAGGTCCAGAGAGCGAGCCCCCAATGCCCGGCCAGGCTAAGCCGCAGAGAC CCTCTCAGCCCCCACCTCAGGTTAGGGCTCTGCCCGCAGCCTGACCTCTAGCCCTGGTGGCAGAGGTCCCTCAGCTGCGAGGCTAATTGG GTGACCACCGATTCCAGCTGCGGTTAATCCAGCTTGGGCCTGTCTGCACTGCGATCCTCTTGGGCTCTCCTAGGATCCCCCCATGCCCCG TAAGAGGTGGAAGACGCTTCCTTCCAGGACAGCAGGCTTTGAGTCCAGCACCCCCAGCCTGCCTTTGCCACCAGCCCCACCCTGCAGAGT ATATGAGGCTTGACAGAGTCTGCCCCCTCCCCCACTGCACCCCAAGAGAGAGAGCCCCAGCCAGCGGAACAGTTTCTATTACCCCCTCCC TGCCCCCAGACCCATGTGATTTCTGCTTTCTTCTTTAGCAAGATATTCTGGTTTCTAGATAAGGAAGAGTCTCTAATGAGCCCCCGAGCC CCAGTCTCTTCAGACTCATGGATTGGTCTGAGGGGTCTGAACGTCTCCTAGCCAATCAGAACTGGCTGTGGACCACCCTAGCACGGCCAC >10121_10121_8_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000547394_length(amino acids)=769AA_BP=327 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLD ALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQ RCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGADEIEMIMTDLERANQRAEVAQREAETLREQLS SANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQ ADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDL SIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDS LRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMARTIGFFYTLFLH -------------------------------------------------------------- >10121_10121_9_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000549414_length(transcript)=4819nt_BP=1041nt CGCCTCCCTTCCCCCTCCCCGCCCGACAGCGGCCGCTCGGGCCCCGGCTCTCGGTTATAAGATGGCGGCGCTGAGCGGTGGCGGTGGTGG CGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGCGCCGGCGCCGCGGCCTCTTCGGCTGCGGA CCCTGCCATTCCGGAGGAGGTGTGGAATATCAAACAAATGATTAAGTTGACACAGGAACATATAGAGGCCCTATTGGACAAATTTGGTGG GGAGCATAATCCACCATCAATATATCTGGAGGCCTATGAAGAATACACCAGCAAGCTAGATGCACTCCAACAAAGAGAACAACAGTTATT GGAATCTCTGGGGAACGGAACTGATTTTTCTGTTTCTAGCTCTGCATCAATGGATACCGTTACATCTTCTTCCTCTTCTAGCCTTTCAGT GCTACCTTCATCTCTTTCAGTTTTTCAAAATCCCACAGATGTGGCACGGAGCAACCCCAAGTCACCACAAAAACCTATCGTTAGAGTCTT CCTGCCCAACAAACAGAGGACAGTGGTACCTGCAAGGTGTGGAGTTACAGTCCGAGACAGTCTAAAGAAAGCACTGATGATGAGAGGTCT AATCCCAGAGTGCTGTGCTGTTTACAGAATTCAGGATGGAGAGAAGAAACCAATTGGTTGGGACACTGATATTTCCTGGCTTACTGGAGA AGAATTGCATGTGGAAGTGTTGGAGAATGTTCCACTTACAACACACAACTTTGTACGAAAAACGTTTTTCACCTTAGCATTTTGTGACTT TTGTCGAAAGCTGCTTTTCCAGGGTTTCCGCTGTCAAACATGTGGTTATAAATTTCACCAGCGTTGTAGTACAGAAGTTCCACTGATGTG TGTTAATTATGACCAACTTGATTTGCTGTTTGTCTCCAAGTTCTTTGAACACCACCCAATACCACAGGAAGAGGCGTCCTTAGCAGAGAC TGCCCTAACATCTGGATCATCCCCTTCCGCACCCGCCTCGGACTCTATTGGGGCCGACGAGATTGAAATGATCATGACGGACCTTGAAAG GGCAAACCAGAGGGCAGAGGTGGCTCAGAGAGAGGCGGAGACCTTAAGGGAACAGCTCTCATCGGCCAATCACTCCCTCCAGCTGGCCTC ACAGATCCAGAAGGCACCAGACGTGGAGCAGGCCATAGAGGTGCTGACCCGCTCCAGCCTAGAAGTTGAGTTGGCCGCCAAGGAGCGGGA GATCGCACAGCTGGTGGAGGACGTGCAGAGACTCCAGGCCAGCCTCACCAAGCTGCGGGAGAATTCGGCCAGCCAGATCTCACAGCTTGA GCAGCAGCTGAGCGCCAAAAACAGCACACTCAAACAACTGGAAGAAAAACTCAAAGGCCAGGCTGACTATGAAGAGGTGAAGAAAGAGCT GAACATTCTGAAGTCCATGGAGTTTGCACCGTCCGAGGGCGCTGGGACACAGGATGCGGCCAAGCCCCTGGAGGTGCTGTTGCTGGAGAA GAACCGCTCGCTGCAGTCCGAGAACGCCGCGCTGCGCATCTCCAACAGCGACCTGAGCGGGTCAGCCAGGAGGAAAGGGAAAGACCAGCC TGAAAGTCGGCGCCCGGGATCTTTGCCGGCCCCCCCTCCTTCTCAGTTGCCCCGCAACCCGGGGGAGCAGGCTTCCAATACTAATGGTAC ACACCAGTTCTCACCAGCGGGGTTAAGTCAAGACTTTTTCAGCTCATCCCTGGCAAGCCCCAGCCTACCCCTGGCTTCTACAGGAAAATT TGCACTAAACTCTCTTCTCCAGCGGCAGCTAATGCAGTCCTTCTACTCCAAGGCTATGCAGGAAGCCGGAAGCACAAGCATGATTTTTTC AACAGGTCCATACAGCACAAACTCCATATCTTCCCAAAGTCCATTACAACAAAGCCCAGATGTCAATGGCATGGCCCCATCCCCCAGCCA GTCAGAAAGTGCTGGGAGCGTCTCCGAGGGCGAGGAGATGGACACTGCAGAAATCGCCCGGCAGGTCAAAGAGCAGCTGATTAAGCACAA TATCGGACAACGTATTTTCGGACATTATGTGTTGGGACTGTCTCAAGGGTCCGTGAGCGAGATTCTGGCCCGGCCCAAGCCATGGAATAA ACTGACTGTTCGTGGCAAGGAGCCATTTCACAAGATGAAACAGTTCCTCTCCGATGAGCAGAACATCCTGGCCCTCCGTAGCATCCAAGG CAGACAAAGAGGTAACATCACCACCCGGATCCGAGCCTCGGAGACTGGCTCTGATGAAGCCATCAAGTCCATCCTAGAGCAAGCCAAGAG GGAGCTCCAAGTGCAGAAAACTGCAGAGCCGGCCCAGCCTTCCTCCGCATCCGGCAGCGGGAACTCTGATGACGCCATCCGCTCCATCCT GCAGCAAGCCCGCCGGGAGATGGAGGCCCAGCAGGCTGCCCTCGACCCTGCCTTAAAGCAGGCACCACTGTCCCAGAGTGACATCACCAT CCTCACCCCCAAGCTTCTGTCCACCTCGCCCATGCCCACCGTGTCCAGCTACCCACCTCTCGCCATCTCCCTGAAGAAGCCCTCCGCAGC TCCTGAGGCCGGTGCCTCTGCTCTGCCGAACCCCCCGGCCCTCAAAAAGGAGGCCCAGGACGCCCCCGGGCTGGACCCCCAGGGAGCAGC CGATTGTGCACAAGGGGTCCTGAGACAGGTGAAAAATGAGGTGGGCCGCAGCGGTGCCTGGAAGGACCACTGGTGGAGCGCGGTGCAGCC GGAGAGAAGAAATGCCGCCTCCTCCGAGGAGGCCAAGGCCGAAGAAACGGGCGGCGGGAAAGAGAAGGGCAGCGGTGGCAGCGGAGGTGG CAGCCAGCCTCGGGCCGAGCGCAGTCAGCTCCAGGGACCCTCGTCGTCAGAGTACTGGAAGGAGTGGCCCAGCGCTGAGTCCCCATACTC CCAGAGCTCAGAGCTGAGTCTGACCGGGGCCAGCCGCAGCGAGACACCACAGAACAGCCCCCTGCCATCCTCCCCGATCGTGCCCATGTC CAAGCCCACCAAGCCCTCGGTCCCCCCGCTGACCCCCGAGCAGTACGAGGTCTACATGTACCAGGAGGTGGACACCATCGAGCTCACCCG GCAGGTTAAGGAAAAGCTGGCCAAGAACGGCATCTGCCAGAGAATCTTCGGGGAGAAGGTGCTGGGCCTGTCCCAGGGCAGCGTCAGCGA CATGCTGTCCCGACCGAAGCCATGGAGCAAGCTGACGCAGAAAGGCCGAGAACCCTTCATCCGGATGCAGCTCTGGCTGAACGGCGAGCT AGGCCAGGGTGTTCTACCCGTCCAGGGCCAGCAGCAAGGGCCAGTCCTCCACTCCGTGACATCGCTCCAGGACCCGCTGCAGCAGGGCTG TGTGAGCTCAGAAAGCACTCCAAAGACCTCCGCCAGCTGCAGCCCTGCCCCTGAGTCCCCGATGAGTTCCAGTGAGTCGGTGAAGAGCCT GACCGAGCTGGTCCAGCAGCCCTGTCCCCCCATCGAGGCGAGCAAGGACAGCAAGCCACCAGAGCCCAGTGACCCGCCAGCATCCGACTC CCAGCCCACAACCCCGCTGCCTCTCTCCGGACACTCGGCCCTCAGCATCCAAGAATTAGTAGCCATGTCCCCGGAGCTGGACACCTACGG CATAACCAAGCGGGTGAAGGAGGTGCTGACGGACAACAACCTCGGCCAGCGCTTATTTGGGGAGACCATCTTAGGGCTCACCCAAGGCTC TGTCTCTGACCTCCTTGCCCGCCCCAAACCCTGGCATAAGCTCAGTCTGAAAGGACGAGAGCCCTTCGTCCGGATGCAGCTGTGGCTGAA CGACCCCAACAATGTGGAGAAGCTGATGGACATGAAACGGATGGAGAAGAAAGCCTACATGAAGCGGCGGCACAGCTCAGTCAGTGACAG CCAGCCCTGCGAACCGCCCTCTGTCGGCACCGAGTACAGCCAGGGCGCCAGCCCCCAGCCCCAGCACCAGCTGAAGAAACCCCGGGTGGT GCTGGCTCCGGAGGAGAAGGAGGCGCTGAAACGAGCGTATCAGCAAAAGCCATACCCGTCACCAAAAACCATCGAAGACCTCGCCACCCA GCTCAACCTGAAAACCAGCACCGTCATCAACTGGTTCCACAACTACAGGTCTCGGATCCGCAGAGAACTGTTCATTGAGGAAATTCAGGC CGGGAGTCAGGGCCAGGCGGGCGCCAGCGACTCACCCTCGGCCCGCAGCGGCCGGGCGGCGCCCAGCTCGGAGGGCGACAGCTGCGACGG CGTGGAGGCCACTGAGGGCCCAGGCAGCGCCGACACCGAGGAGCCCAAGTCTCAGGGAGAGGCCGAGCGGGAGGAGGTGCCGCGGCCGGC GGAGCAGACGGAGCCGCCGCCCTCGGGGACCCCGGGCCCGGACGACGCCCGCGACGACGACCACGAGGGAGGCCCCGTGGAAGGCCCGGG GCCCCTGCCCAGCCCCGCCTCCGCGACCGCCACCGCCGCGCCCGCGGCCCCCGAGGACGCCGCTACCTCAGCCGCCGCCGCGCCGGGGGA GGGCCCCGCGGCCCCGAGCTCCGCGCCGCCGCCCAGCAACAGCAGCAGCAGCAGCGCCCCCCGCAGGCCCAGCTCGCTGCAGAGCCTTTT CGGCCTCCCCGAGGCCGCGGGCGCCCGGGACTCGCGCGACAACCCCCTGCGCAAGAAGAAGGCCGCGAACTTGAACAGCATCATCCACCG >10121_10121_9_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000549414_length(amino acids)=1586AA_BP=327 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLD ALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQ RCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGADEIEMIMTDLERANQRAEVAQREAETLREQLS SANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQ ADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPESRRPGSLPAPPPSQLPRNP GEQASNTNGTHQFSPAGLSQDFFSSSLASPSLPLASTGKFALNSLLQRQLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQQSPD VNGMAPSPSQSESAGSVSEGEEMDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQ NILALRSIQGRQRGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSDDAIRSILQQARREMEAQQAALDPALKQ APLSQSDITILTPKLLSTSPMPTVSSYPPLAISLKKPSAAPEAGASALPNPPALKKEAQDAPGLDPQGAADCAQGVLRQVKNEVGRSGAW KDHWWSAVQPERRNAASSEEAKAEETGGGKEKGSGGSGGGSQPRAERSQLQGPSSSEYWKEWPSAESPYSQSSELSLTGASRSETPQNSP LPSSPIVPMSKPTKPSVPPLTPEQYEVYMYQEVDTIELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFI RMQLWLNGELGQGVLPVQGQQQGPVLHSVTSLQDPLQQGCVSSESTPKTSASCSPAPESPMSSSESVKSLTELVQQPCPPIEASKDSKPP EPSDPPASDSQPTTPLPLSGHSALSIQELVAMSPELDTYGITKRVKEVLTDNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGRE PFVRMQLWLNDPNNVEKLMDMKRMEKKAYMKRRHSSVSDSQPCEPPSVGTEYSQGASPQPQHQLKKPRVVLAPEEKEALKRAYQQKPYPS PKTIEDLATQLNLKTSTVINWFHNYRSRIRRELFIEEIQAGSQGQAGASDSPSARSGRAAPSSEGDSCDGVEATEGPGSADTEEPKSQGE AEREEVPRPAEQTEPPPSGTPGPDDARDDDHEGGPVEGPGPLPSPASATATAAPAAPEDAATSAAAAPGEGPAAPSSAPPPSNSSSSSAP -------------------------------------------------------------- >10121_10121_10_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000550008_length(transcript)=4717nt_BP=1041nt CGCCTCCCTTCCCCCTCCCCGCCCGACAGCGGCCGCTCGGGCCCCGGCTCTCGGTTATAAGATGGCGGCGCTGAGCGGTGGCGGTGGTGG CGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGCGCCGGCGCCGCGGCCTCTTCGGCTGCGGA CCCTGCCATTCCGGAGGAGGTGTGGAATATCAAACAAATGATTAAGTTGACACAGGAACATATAGAGGCCCTATTGGACAAATTTGGTGG GGAGCATAATCCACCATCAATATATCTGGAGGCCTATGAAGAATACACCAGCAAGCTAGATGCACTCCAACAAAGAGAACAACAGTTATT GGAATCTCTGGGGAACGGAACTGATTTTTCTGTTTCTAGCTCTGCATCAATGGATACCGTTACATCTTCTTCCTCTTCTAGCCTTTCAGT GCTACCTTCATCTCTTTCAGTTTTTCAAAATCCCACAGATGTGGCACGGAGCAACCCCAAGTCACCACAAAAACCTATCGTTAGAGTCTT CCTGCCCAACAAACAGAGGACAGTGGTACCTGCAAGGTGTGGAGTTACAGTCCGAGACAGTCTAAAGAAAGCACTGATGATGAGAGGTCT AATCCCAGAGTGCTGTGCTGTTTACAGAATTCAGGATGGAGAGAAGAAACCAATTGGTTGGGACACTGATATTTCCTGGCTTACTGGAGA AGAATTGCATGTGGAAGTGTTGGAGAATGTTCCACTTACAACACACAACTTTGTACGAAAAACGTTTTTCACCTTAGCATTTTGTGACTT TTGTCGAAAGCTGCTTTTCCAGGGTTTCCGCTGTCAAACATGTGGTTATAAATTTCACCAGCGTTGTAGTACAGAAGTTCCACTGATGTG TGTTAATTATGACCAACTTGATTTGCTGTTTGTCTCCAAGTTCTTTGAACACCACCCAATACCACAGGAAGAGGCGTCCTTAGCAGAGAC TGCCCTAACATCTGGATCATCCCCTTCCGCACCCGCCTCGGACTCTATTGGGGCCGACGAGATTGAAATGATCATGACGGACCTTGAAAG GGCAAACCAGAGGGCAGAGGTGGCTCAGAGAGAGGCGGAGACCTTAAGGGAACAGCTCTCATCGGCCAATCACTCCCTCCAGCTGGCCTC ACAGATCCAGAAGGCACCAGACGTGGAGCAGGCCATAGAGGTGCTGACCCGCTCCAGCCTAGAAGTTGAGTTGGCCGCCAAGGAGCGGGA GATCGCACAGCTGGTGGAGGACGTGCAGAGACTCCAGGCCAGCCTCACCAAGCTGCGGGAGAATTCGGCCAGCCAGATCTCACAGCTTGA GCAGCAGCTGAGCGCCAAAAACAGCACACTCAAACAACTGGAAGAAAAACTCAAAGGCCAGGCTGACTATGAAGAGGTGAAGAAAGAGCT GAACATTCTGAAGTCCATGGAGTTTGCACCGTCCGAGGGCGCTGGGACACAGGATGCGGCCAAGCCCCTGGAGGTGCTGTTGCTGGAGAA GAACCGCTCGCTGCAGTCCGAGAACGCCGCGCTGCGCATCTCCAACAGCGACCTGAGCGGGTCAGCCAGGAGGAAAGGGAAAGACCAGCC TGAAAGTCGGCGCCCGGGATCTTTGCCGGCCCCCCCTCCTTCTCAGTTGCCCCGCAACCCGGGGGAGCAGGCTTCCAATACTAATGGTAC ACACCAGTTCTCACCAGCGGGGTTAAGTCAAGACTTTTTCAGCTCATCCCTGGCAAGCCCCAGCCTACCCCTGGCTTCTACAGGAAAATT TGCACTAAACTCTCTTCTCCAGCGGCAGCTAATGCAGTCCTTCTACTCCAAGGCTATGCAGGAAGCCGGAAGCACAAGCATGATTTTTTC AACAGGTCCATACAGCACAAACTCCATATCTTCCCAAAGTCCATTACAACAAAGCCCAGATGTCAATGGCATGGCCCCATCCCCCAGCCA GTCAGAAAGTGCTGGGAGCGTCTCCGAGGGCGAGGAGATGGACACTGCAGAAATCGCCCGGCAGGTCAAAGAGCAGCTGATTAAGCACAA TATCGGACAACGTATTTTCGGACATTATGTGTTGGGACTGTCTCAAGGGTCCGTGAGCGAGATTCTGGCCCGGCCCAAGCCATGGAATAA ACTGACTGTTCGTGGCAAGGAGCCATTTCACAAGATGAAACAGTTCCTCTCCGATGAGCAGAACATCCTGGCCCTCCGTAGCATCCAAGG CAGACAAAGAGCAGAGCCGGCCCAGCCTTCCTCCGCATCCGGCAGCGGGAACTCTGATGACGCCATCCGCTCCATCCTGCAGCAAGCCCG CCGGGAGATGGAGGCCCAGCAGGCTGCCCTCGACCCTGCCTTAAAGCAGGCACCACTGTCCCAGAGTGACATCACCATCCTCACCCCCAA GCTTCTGTCCACCTCGCCCATGCCCACCGTGTCCAGCTACCCACCTCTCGCCATCTCCCTGAAGAAGCCCTCCGCAGCTCCTGAGGCCGG TGCCTCTGCTCTGCCGAACCCCCCGGCCCTCAAAAAGGAGGCCCAGGACGCCCCCGGGCTGGACCCCCAGGGAGCAGCCGATTGTGCACA AGGGGTCCTGAGACAGGTGAAAAATGAGGTGGGCCGCAGCGGTGCCTGGAAGGACCACTGGTGGAGCGCGGTGCAGCCGGAGAGAAGAAA TGCCGCCTCCTCCGAGGAGGCCAAGGCCGAAGAAACGGGCGGCGGGAAAGAGAAGGGCAGCGGTGGCAGCGGAGGTGGCAGCCAGCCTCG GGCCGAGCGCAGTCAGCTCCAGGGACCCTCGTCGTCAGAGTACTGGAAGGAGTGGCCCAGCGCTGAGTCCCCATACTCCCAGAGCTCAGA GCTGAGTCTGACCGGGGCCAGCCGCAGCGAGACACCACAGAACAGCCCCCTGCCATCCTCCCCGATCGTGCCCATGTCCAAGCCCACCAA GCCCTCGGTCCCCCCGCTGACCCCCGAGCAGTACGAGGTCTACATGTACCAGGAGGTGGACACCATCGAGCTCACCCGGCAGGTTAAGGA AAAGCTGGCCAAGAACGGCATCTGCCAGAGAATCTTCGGGGAGAAGGTGCTGGGCCTGTCCCAGGGCAGCGTCAGCGACATGCTGTCCCG ACCGAAGCCATGGAGCAAGCTGACGCAGAAAGGCCGAGAACCCTTCATCCGGATGCAGCTCTGGCTGAACGGCGAGCTAGGCCAGGGTGT TCTACCCGTCCAGGGCCAGCAGCAAGGGCCAGTCCTCCACTCCGTGACATCGCTCCAGGACCCGCTGCAGCAGGGCTGTGTGAGCTCAGA AAGCACTCCAAAGACCTCCGCCAGCTGCAGCCCTGCCCCTGAGTCCCCGATGAGTTCCAGTGAGTCGGTGAAGAGCCTGACCGAGCTGGT CCAGCAGCCCTGTCCCCCCATCGAGGCGAGCAAGGACAGCAAGCCACCAGAGCCCAGTGACCCGCCAGCATCCGACTCCCAGCCCACAAC CCCGCTGCCTCTCTCCGGACACTCGGCCCTCAGCATCCAAGAATTAGTAGCCATGTCCCCGGAGCTGGACACCTACGGCATAACCAAGCG GGTGAAGGAGGTGCTGACGGACAACAACCTCGGCCAGCGCTTATTTGGGGAGACCATCTTAGGGCTCACCCAAGGCTCTGTCTCTGACCT CCTTGCCCGCCCCAAACCCTGGCATAAGCTCAGTCTGAAAGGACGAGAGCCCTTCGTCCGGATGCAGCTGTGGCTGAACGACCCCAACAA TGTGGAGAAGCTGATGGACATGAAACGGATGGAGAAGAAAGCCTACATGAAGCGGCGGCACAGCTCAGTCAGTGACAGCCAGCCCTGCGA ACCGCCCTCTGTCGGCACCGAGTACAGCCAGGGCGCCAGCCCCCAGCCCCAGCACCAGCTGAAGAAACCCCGGGTGGTGCTGGCTCCGGA GGAGAAGGAGGCGCTGAAACGAGCGTATCAGCAAAAGCCATACCCGTCACCAAAAACCATCGAAGACCTCGCCACCCAGCTCAACCTGAA AACCAGCACCGTCATCAACTGGTTCCACAACTACAGGTCTCGGATCCGCAGAGAACTGTTCATTGAGGAAATTCAGGCCGGGAGTCAGGG CCAGGCGGGCGCCAGCGACTCACCCTCGGCCCGCAGCGGCCGGGCGGCGCCCAGCTCGGAGGGCGACAGCTGCGACGGCGTGGAGGCCAC TGAGGGCCCAGGCAGCGCCGACACCGAGGAGCCCAAGTCTCAGGGAGAGGCCGAGCGGGAGGAGGTGCCGCGGCCGGCGGAGCAGACGGA GCCGCCGCCCTCGGGGACCCCGGGCCCGGACGACGCCCGCGACGACGACCACGAGGGAGGCCCCGTGGAAGGCCCGGGGCCCCTGCCCAG CCCCGCCTCCGCGACCGCCACCGCCGCGCCCGCGGCCCCCGAGGACGCCGCTACCTCAGCCGCCGCCGCGCCGGGGGAGGGCCCCGCGGC CCCGAGCTCCGCGCCGCCGCCCAGCAACAGCAGCAGCAGCAGCGCCCCCCGCAGGCCCAGCTCGCTGCAGAGCCTTTTCGGCCTCCCCGA GGCCGCGGGCGCCCGGGACTCGCGCGACAACCCCCTGCGCAAGAAGAAGGCCGCGAACTTGAACAGCATCATCCACCGCCTGGAGAAGGC >10121_10121_10_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000550008_length(amino acids)=1552AA_BP=327 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLD ALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQ RCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGADEIEMIMTDLERANQRAEVAQREAETLREQLS SANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQ ADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPESRRPGSLPAPPPSQLPRNP GEQASNTNGTHQFSPAGLSQDFFSSSLASPSLPLASTGKFALNSLLQRQLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQQSPD VNGMAPSPSQSESAGSVSEGEEMDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQ NILALRSIQGRQRAEPAQPSSASGSGNSDDAIRSILQQARREMEAQQAALDPALKQAPLSQSDITILTPKLLSTSPMPTVSSYPPLAISL KKPSAAPEAGASALPNPPALKKEAQDAPGLDPQGAADCAQGVLRQVKNEVGRSGAWKDHWWSAVQPERRNAASSEEAKAEETGGGKEKGS GGSGGGSQPRAERSQLQGPSSSEYWKEWPSAESPYSQSSELSLTGASRSETPQNSPLPSSPIVPMSKPTKPSVPPLTPEQYEVYMYQEVD TIELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLNGELGQGVLPVQGQQQGPVLHSVTSLQD PLQQGCVSSESTPKTSASCSPAPESPMSSSESVKSLTELVQQPCPPIEASKDSKPPEPSDPPASDSQPTTPLPLSGHSALSIQELVAMSP ELDTYGITKRVKEVLTDNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGREPFVRMQLWLNDPNNVEKLMDMKRMEKKAYMKRRH SSVSDSQPCEPPSVGTEYSQGASPQPQHQLKKPRVVLAPEEKEALKRAYQQKPYPSPKTIEDLATQLNLKTSTVINWFHNYRSRIRRELF IEEIQAGSQGQAGASDSPSARSGRAAPSSEGDSCDGVEATEGPGSADTEEPKSQGEAEREEVPRPAEQTEPPPSGTPGPDDARDDDHEGG PVEGPGPLPSPASATATAAPAAPEDAATSAAAAPGEGPAAPSSAPPPSNSSSSSAPRRPSSLQSLFGLPEAAGARDSRDNPLRKKKAANL -------------------------------------------------------------- >10121_10121_11_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000556210_length(transcript)=4411nt_BP=1041nt CGCCTCCCTTCCCCCTCCCCGCCCGACAGCGGCCGCTCGGGCCCCGGCTCTCGGTTATAAGATGGCGGCGCTGAGCGGTGGCGGTGGTGG CGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGCGCCGGCGCCGCGGCCTCTTCGGCTGCGGA CCCTGCCATTCCGGAGGAGGTGTGGAATATCAAACAAATGATTAAGTTGACACAGGAACATATAGAGGCCCTATTGGACAAATTTGGTGG GGAGCATAATCCACCATCAATATATCTGGAGGCCTATGAAGAATACACCAGCAAGCTAGATGCACTCCAACAAAGAGAACAACAGTTATT GGAATCTCTGGGGAACGGAACTGATTTTTCTGTTTCTAGCTCTGCATCAATGGATACCGTTACATCTTCTTCCTCTTCTAGCCTTTCAGT GCTACCTTCATCTCTTTCAGTTTTTCAAAATCCCACAGATGTGGCACGGAGCAACCCCAAGTCACCACAAAAACCTATCGTTAGAGTCTT CCTGCCCAACAAACAGAGGACAGTGGTACCTGCAAGGTGTGGAGTTACAGTCCGAGACAGTCTAAAGAAAGCACTGATGATGAGAGGTCT AATCCCAGAGTGCTGTGCTGTTTACAGAATTCAGGATGGAGAGAAGAAACCAATTGGTTGGGACACTGATATTTCCTGGCTTACTGGAGA AGAATTGCATGTGGAAGTGTTGGAGAATGTTCCACTTACAACACACAACTTTGTACGAAAAACGTTTTTCACCTTAGCATTTTGTGACTT TTGTCGAAAGCTGCTTTTCCAGGGTTTCCGCTGTCAAACATGTGGTTATAAATTTCACCAGCGTTGTAGTACAGAAGTTCCACTGATGTG TGTTAATTATGACCAACTTGATTTGCTGTTTGTCTCCAAGTTCTTTGAACACCACCCAATACCACAGGAAGAGGCGTCCTTAGCAGAGAC TGCCCTAACATCTGGATCATCCCCTTCCGCACCCGCCTCGGACTCTATTGGGGCCGACGAGATTGAAATGATCATGACGGACCTTGAAAG GGCAAACCAGAGGGCAGAGGTGGCTCAGAGAGAGGCGGAGACCTTAAGGGAACAGCTCTCATCGGCCAATCACTCCCTCCAGCTGGCCTC ACAGATCCAGAAGGCACCAGACGTGGAGCAGGCCATAGAGGTGCTGACCCGCTCCAGCCTAGAAGTTGAGTTGGCCGCCAAGGAGCGGGA GATCGCACAGCTGGTGGAGGACGTGCAGAGACTCCAGGCCAGCCTCACCAAGCTGCGGGAGAATTCGGCCAGCCAGATCTCACAGCTTGA GCAGCAGCTGAGCGCCAAAAACAGCACACTCAAACAACTGGAAGAAAAACTCAAAGGCCAGGCTGACTATGAAGAGGTGAAGAAAGAGCT GAACATTCTGAAGTCCATGGAGTTTGCACCGTCCGAGGGCGCTGGGACACAGGATGCGGCCAAGCCCCTGGAGGTGCTGTTGCTGGAGAA GAACCGCTCGCTGCAGTCCGAGAACGCCGCGCTGCGCATCTCCAACAGCGACCTGAGCGGTCCATACAGCACAAACTCCATATCTTCCCA AAGTCCATTACAACAAAGCCCAGATGTCAATGGCATGGCCCCATCCCCCAGCCAGTCAGAAAGTGCTGGGAGCGTCTCCGAGGGCGAGGA GATGGACACTGCAGAAATCGCCCGGCAGGTCAAAGAGCAGCTGATTAAGCACAATATCGGACAACGTATTTTCGGACATTATGTGTTGGG ACTGTCTCAAGGGTCCGTGAGCGAGATTCTGGCCCGGCCCAAGCCATGGAATAAACTGACTGTTCGTGGCAAGGAGCCATTTCACAAGAT GAAACAGTTCCTCTCCGATGAGCAGAACATCCTGGCCCTCCGTAGCATCCAAGGCAGACAAAGAGCAGAGCCGGCCCAGCCTTCCTCCGC ATCCGGCAGCGGGAACTCTGATGACGCCATCCGCTCCATCCTGCAGCAAGCCCGCCGGGAGATGGAGGCCCAGCAGGCTGCCCTCGACCC TGCCTTAAAGCAGGCACCACTGTCCCAGAGTGACATCACCATCCTCACCCCCAAGCTTCTGTCCACCTCGCCCATGCCCACCGTGTCCAG CTACCCACCTCTCGCCATCTCCCTGAAGAAGCCCTCCGCAGCTCCTGAGGCCGGTGCCTCTGCTCTGCCGAACCCCCCGGCCCTCAAAAA GGAGGCCCAGGACGCCCCCGGGCTGGACCCCCAGGGAGCAGCCGATTGTGCACAAGGGGTCCTGAGACAGGTGAAAAATGAGGTGGGCCG CAGCGGTGCCTGGAAGGACCACTGGTGGAGCGCGGTGCAGCCGGAGAGAAGAAATGCCGCCTCCTCCGAGGAGGCCAAGGCCGAAGAAAC GGGCGGCGGGAAAGAGAAGGGCAGCGGTGGCAGCGGAGGTGGCAGCCAGCCTCGGGCCGAGCGCAGTCAGCTCCAGGGACCCTCGTCGTC AGAGTACTGGAAGGAGTGGCCCAGCGCTGAGTCCCCATACTCCCAGAGCTCAGAGCTGAGTCTGACCGGGGCCAGCCGCAGCGAGACACC ACAGAACAGCCCCCTGCCATCCTCCCCGATCGTGCCCATGTCCAAGCCCACCAAGCCCTCGGTCCCCCCGCTGACCCCCGAGCAGTACGA GGTCTACATGTACCAGGAGGTGGACACCATCGAGCTCACCCGGCAGGTTAAGGAAAAGCTGGCCAAGAACGGCATCTGCCAGAGAATCTT CGGGGAGAAGGTGCTGGGCCTGTCCCAGGGCAGCGTCAGCGACATGCTGTCCCGACCGAAGCCATGGAGCAAGCTGACGCAGAAAGGCCG AGAACCCTTCATCCGGATGCAGCTCTGGCTGAACGGCGAGCTAGGCCAGGGTGTTCTACCCGTCCAGGGCCAGCAGCAAGGGCCAGTCCT CCACTCCGTGACATCGCTCCAGGACCCGCTGCAGCAGGGCTGTGTGAGCTCAGAAAGCACTCCAAAGACCTCCGCCAGCTGCAGCCCTGC CCCTGAGTCCCCGATGAGTTCCAGTGAGTCGGTGAAGAGCCTGACCGAGCTGGTCCAGCAGCCCTGTCCCCCCATCGAGGCGAGCAAGGA CAGCAAGCCACCAGAGCCCAGTGACCCGCCAGCATCCGACTCCCAGCCCACAACCCCGCTGCCTCTCTCCGGACACTCGGCCCTCAGCAT CCAAGAATTAGTAGCCATGTCCCCGGAGCTGGACACCTACGGCATAACCAAGCGGGTGAAGGAGGTGCTGACGGACAACAACCTCGGCCA GCGCTTATTTGGGGAGACCATCTTAGGGCTCACCCAAGGCTCTGTCTCTGACCTCCTTGCCCGCCCCAAACCCTGGCATAAGCTCAGTCT GAAAGGACGAGAGCCCTTCGTCCGGATGCAGCTGTGGCTGAACGACCCCAACAATGTGGAGAAGCTGATGGACATGAAACGGATGGAGAA GAAAGCCTACATGAAGCGGCGGCACAGCTCAGTCAGTGACAGCCAGCCCTGCGAACCGCCCTCTGTCGGCACCGAGTACAGCCAGGGCGC CAGCCCCCAGCCCCAGCACCAGCTGAAGAAACCCCGGGTGGTGCTGGCTCCGGAGGAGAAGGAGGCGCTGAAACGAGCGTATCAGCAAAA GCCATACCCGTCACCAAAAACCATCGAAGACCTCGCCACCCAGCTCAACCTGAAAACCAGCACCGTCATCAACTGGTTCCACAACTACAG GTCTCGGATCCGCAGAGAACTGTTCATTGAGGAAATTCAGGCCGGGAGTCAGGGCCAGGCGGGCGCCAGCGACTCACCCTCGGCCCGCAG CGGCCGGGCGGCGCCCAGCTCGGAGGGCGACAGCTGCGACGGCGTGGAGGCCACTGAGGGCCCAGGCAGCGCCGACACCGAGGAGCCCAA GTCTCAGGGAGAGGCCGAGCGGGAGGAGGTGCCGCGGCCGGCGGAGCAGACGGAGCCGCCGCCCTCGGGGACCCCGGGCCCGGACGACGC CCGCGACGACGACCACGAGGGAGGCCCCGTGGAAGGCCCGGGGCCCCTGCCCAGCCCCGCCTCCGCGACCGCCACCGCCGCGCCCGCGGC CCCCGAGGACGCCGCTACCTCAGCCGCCGCCGCGCCGGGGGAGGGCCCCGCGGCCCCGAGCTCCGCGCCGCCGCCCAGCAACAGCAGCAG CAGCAGCGCCCCCCGCAGGCCCAGCTCGCTGCAGAGCCTTTTCGGCCTCCCCGAGGCCGCGGGCGCCCGGGACTCGCGCGACAACCCCCT GCGCAAGAAGAAGGCCGCGAACTTGAACAGCATCATCCACCGCCTGGAGAAGGCCGCCAGCCGGGAGGAACCTATCGAATGGGAGTTCTG >10121_10121_11_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000556210_length(amino acids)=1450AA_BP=327 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLD ALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQ RCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGADEIEMIMTDLERANQRAEVAQREAETLREQLS SANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQ ADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGPYSTNSISSQSPLQQSPDVNGMAPSPSQSE SAGSVSEGEEMDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQ RAEPAQPSSASGSGNSDDAIRSILQQARREMEAQQAALDPALKQAPLSQSDITILTPKLLSTSPMPTVSSYPPLAISLKKPSAAPEAGAS ALPNPPALKKEAQDAPGLDPQGAADCAQGVLRQVKNEVGRSGAWKDHWWSAVQPERRNAASSEEAKAEETGGGKEKGSGGSGGGSQPRAE RSQLQGPSSSEYWKEWPSAESPYSQSSELSLTGASRSETPQNSPLPSSPIVPMSKPTKPSVPPLTPEQYEVYMYQEVDTIELTRQVKEKL AKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLNGELGQGVLPVQGQQQGPVLHSVTSLQDPLQQGCVSSEST PKTSASCSPAPESPMSSSESVKSLTELVQQPCPPIEASKDSKPPEPSDPPASDSQPTTPLPLSGHSALSIQELVAMSPELDTYGITKRVK EVLTDNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGREPFVRMQLWLNDPNNVEKLMDMKRMEKKAYMKRRHSSVSDSQPCEPP SVGTEYSQGASPQPQHQLKKPRVVLAPEEKEALKRAYQQKPYPSPKTIEDLATQLNLKTSTVINWFHNYRSRIRRELFIEEIQAGSQGQA GASDSPSARSGRAAPSSEGDSCDGVEATEGPGSADTEEPKSQGEAEREEVPRPAEQTEPPPSGTPGPDDARDDDHEGGPVEGPGPLPSPA SATATAAPAAPEDAATSAAAAPGEGPAAPSSAPPPSNSSSSSAPRRPSSLQSLFGLPEAAGARDSRDNPLRKKKAANLNSIIHRLEKAAS -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for BRAF-CUX1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for BRAF-CUX1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | BRAF | P15056 | DB08881 | Vemurafenib | Inhibitor | Small molecule | Approved |
| Hgene | BRAF | P15056 | DB08881 | Vemurafenib | Inhibitor | Small molecule | Approved |
| Hgene | BRAF | P15056 | DB08881 | Vemurafenib | Inhibitor | Small molecule | Approved |
| Hgene | BRAF | P15056 | DB08896 | Regorafenib | Inhibitor | Small molecule | Approved |
| Hgene | BRAF | P15056 | DB08896 | Regorafenib | Inhibitor | Small molecule | Approved |
| Hgene | BRAF | P15056 | DB08896 | Regorafenib | Inhibitor | Small molecule | Approved |
| Hgene | BRAF | P15056 | DB14840 | Ripretinib | Inhibitor | Small molecule | Approved |
| Hgene | BRAF | P15056 | DB14840 | Ripretinib | Inhibitor | Small molecule | Approved |
| Hgene | BRAF | P15056 | DB14840 | Ripretinib | Inhibitor | Small molecule | Approved |
| Hgene | BRAF | P15056 | DB00398 | Sorafenib | Inhibitor | Small molecule | Approved|Investigational |
| Hgene | BRAF | P15056 | DB00398 | Sorafenib | Inhibitor | Small molecule | Approved|Investigational |
| Hgene | BRAF | P15056 | DB00398 | Sorafenib | Inhibitor | Small molecule | Approved|Investigational |
| Hgene | BRAF | P15056 | DB08912 | Dabrafenib | Antagonist|Inhibitor | Small molecule | Approved|Investigational |
| Hgene | BRAF | P15056 | DB08912 | Dabrafenib | Antagonist|Inhibitor | Small molecule | Approved|Investigational |
| Hgene | BRAF | P15056 | DB08912 | Dabrafenib | Antagonist|Inhibitor | Small molecule | Approved|Investigational |
| Hgene | BRAF | P15056 | DB11718 | Encorafenib | Inhibitor | Small molecule | Approved|Investigational |
| Hgene | BRAF | P15056 | DB11718 | Encorafenib | Inhibitor | Small molecule | Approved|Investigational |
| Hgene | BRAF | P15056 | DB11718 | Encorafenib | Inhibitor | Small molecule | Approved|Investigational |
| Hgene | BRAF | P15056 | DB12010 | Fostamatinib | Inhibitor | Small molecule | Approved|Investigational |
| Hgene | BRAF | P15056 | DB12010 | Fostamatinib | Inhibitor | Small molecule | Approved|Investigational |
| Hgene | BRAF | P15056 | DB12010 | Fostamatinib | Inhibitor | Small molecule | Approved|Investigational |
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Related Diseases for BRAF-CUX1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | BRAF | C0025202 | melanoma | 24 | CGI;CTD_human;UNIPROT |
| Hgene | BRAF | C1275081 | Cardio-facio-cutaneous syndrome | 14 | CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
| Hgene | BRAF | C0009402 | Colorectal Carcinoma | 8 | CTD_human;UNIPROT |
| Hgene | BRAF | C0028326 | Noonan Syndrome | 8 | CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET |
| Hgene | BRAF | C0238463 | Papillary thyroid carcinoma | 8 | CTD_human;ORPHANET |
| Hgene | BRAF | C0040136 | Thyroid Neoplasm | 6 | CGI;CTD_human |
| Hgene | BRAF | C0151468 | Thyroid Gland Follicular Adenoma | 6 | CTD_human |
| Hgene | BRAF | C0175704 | LEOPARD Syndrome | 6 | CLINGEN;GENOMICS_ENGLAND |
| Hgene | BRAF | C0549473 | Thyroid carcinoma | 6 | CGI;CTD_human |
| Hgene | BRAF | C3150970 | NOONAN SYNDROME 7 | 5 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
| Hgene | BRAF | C0009404 | Colorectal Neoplasms | 4 | CTD_human |
| Hgene | BRAF | C3150971 | LEOPARD SYNDROME 3 | 4 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
| Hgene | BRAF | C1519086 | Pilomyxoid astrocytoma | 3 | ORPHANET |
| Hgene | BRAF | C0004565 | Melanoma, B16 | 2 | CTD_human |
| Hgene | BRAF | C0009075 | Melanoma, Cloudman S91 | 2 | CTD_human |
| Hgene | BRAF | C0018598 | Melanoma, Harding-Passey | 2 | CTD_human |
| Hgene | BRAF | C0023443 | Hairy Cell Leukemia | 2 | CGI;ORPHANET |
| Hgene | BRAF | C0025205 | Melanoma, Experimental | 2 | CTD_human |
| Hgene | BRAF | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
| Hgene | BRAF | C0152013 | Adenocarcinoma of lung (disorder) | 2 | CGI;CTD_human |
| Hgene | BRAF | C0376358 | Malignant neoplasm of prostate | 2 | CTD_human |
| Hgene | BRAF | C0587248 | Costello syndrome (disorder) | 2 | CLINGEN;CTD_human |
| Hgene | BRAF | C3501843 | Nonmedullary Thyroid Carcinoma | 2 | CTD_human |
| Hgene | BRAF | C3501844 | Familial Nonmedullary Thyroid Cancer | 2 | CTD_human |
| Hgene | BRAF | C0002448 | Ameloblastoma | 1 | CTD_human |
| Hgene | BRAF | C0004114 | Astrocytoma | 1 | CTD_human |
| Hgene | BRAF | C0010276 | Craniopharyngioma | 1 | CTD_human;ORPHANET |
| Hgene | BRAF | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
| Hgene | BRAF | C0017638 | Glioma | 1 | CGI;CTD_human |
| Hgene | BRAF | C0019621 | Histiocytosis, Langerhans-Cell | 1 | CGI;ORPHANET |
| Hgene | BRAF | C0022665 | Kidney Neoplasm | 1 | CTD_human |
| Hgene | BRAF | C0023903 | Liver neoplasms | 1 | CTD_human |
| Hgene | BRAF | C0024232 | Lymphatic Metastasis | 1 | CTD_human |
| Hgene | BRAF | C0024694 | Mandibular Neoplasms | 1 | CTD_human |
| Hgene | BRAF | C0027659 | Neoplasms, Experimental | 1 | CTD_human |
| Hgene | BRAF | C0027962 | Melanocytic nevus | 1 | GENOMICS_ENGLAND |
| Hgene | BRAF | C0036920 | Sezary Syndrome | 1 | CTD_human |
| Hgene | BRAF | C0041409 | Turner Syndrome, Male | 1 | CTD_human |
| Hgene | BRAF | C0079773 | Lymphoma, T-Cell, Cutaneous | 1 | CTD_human |
| Hgene | BRAF | C0205768 | Subependymal Giant Cell Astrocytoma | 1 | CTD_human |
| Hgene | BRAF | C0206686 | Adrenocortical carcinoma | 1 | CTD_human |
| Hgene | BRAF | C0206754 | Neuroendocrine Tumors | 1 | CTD_human |
| Hgene | BRAF | C0259783 | mixed gliomas | 1 | CTD_human |
| Hgene | BRAF | C0278875 | Adult Craniopharyngioma | 1 | CTD_human |
| Hgene | BRAF | C0280783 | Juvenile Pilocytic Astrocytoma | 1 | CTD_human |
| Hgene | BRAF | C0280785 | Diffuse Astrocytoma | 1 | CTD_human |
| Hgene | BRAF | C0334579 | Anaplastic astrocytoma | 1 | CGI;CTD_human |
| Hgene | BRAF | C0334580 | Protoplasmic astrocytoma | 1 | CTD_human |
| Hgene | BRAF | C0334581 | Gemistocytic astrocytoma | 1 | CTD_human |
| Hgene | BRAF | C0334582 | Fibrillary Astrocytoma | 1 | CTD_human |
| Hgene | BRAF | C0334583 | Pilocytic Astrocytoma | 1 | CGI;CTD_human |
| Hgene | BRAF | C0338070 | Childhood Cerebral Astrocytoma | 1 | CTD_human |
| Hgene | BRAF | C0345904 | Malignant neoplasm of liver | 1 | CTD_human |
| Hgene | BRAF | C0376407 | Granulomatous Slack Skin | 1 | CTD_human |
| Hgene | BRAF | C0406803 | Syringocystadenoma Papilliferum | 1 | GENOMICS_ENGLAND |
| Hgene | BRAF | C0431128 | Papillary craniopharyngioma | 1 | CTD_human |
| Hgene | BRAF | C0431129 | Adamantinous Craniopharyngioma | 1 | CTD_human |
| Hgene | BRAF | C0547065 | Mixed oligoastrocytoma | 1 | CTD_human |
| Hgene | BRAF | C0555198 | Malignant Glioma | 1 | CTD_human |
| Hgene | BRAF | C0596263 | Carcinogenesis | 1 | CTD_human |
| Hgene | BRAF | C0684249 | Carcinoma of lung | 1 | CGI;UNIPROT |
| Hgene | BRAF | C0740457 | Malignant neoplasm of kidney | 1 | CTD_human |
| Hgene | BRAF | C0750935 | Cerebral Astrocytoma | 1 | CTD_human |
| Hgene | BRAF | C0750936 | Intracranial Astrocytoma | 1 | CTD_human |
| Hgene | BRAF | C0751061 | Craniopharyngioma, Child | 1 | CTD_human |
| Hgene | BRAF | C0920269 | Microsatellite Instability | 1 | CTD_human |
| Hgene | BRAF | C1527404 | Female Pseudo-Turner Syndrome | 1 | CTD_human |
| Hgene | BRAF | C1704230 | Grade I Astrocytoma | 1 | CTD_human |
| Hgene | BRAF | C1721098 | Replication Error Phenotype | 1 | CTD_human |
| Hgene | BRAF | C2239176 | Liver carcinoma | 1 | CTD_human |
| Hgene | BRAF | C4551484 | Leopard Syndrome 1 | 1 | GENOMICS_ENGLAND |
| Hgene | BRAF | C4551602 | Noonan Syndrome 1 | 1 | CTD_human |
| Hgene | BRAF | C4721532 | Lymphoma, Non-Hodgkin, Familial | 1 | UNIPROT |
| Hgene | BRAF | C4733333 | familial non-medullary thyroid cancer | 1 | GENOMICS_ENGLAND |
| Tgene | C0041696 | Unipolar Depression | 3 | PSYGENET | |
| Tgene | C1269683 | Major Depressive Disorder | 3 | PSYGENET | |
| Tgene | C0596263 | Carcinogenesis | 1 | CTD_human |
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