Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:TCN1-MS4A4A (FusionGDB2 ID:HG6947TG51338)

Fusion Gene Summary for TCN1-MS4A4A

check button Fusion gene summary
Fusion gene informationFusion gene name: TCN1-MS4A4A
Fusion gene ID: hg6947tg51338
HgeneTgene
Gene symbol

TCN1

MS4A4A

Gene ID

6947

51338

Gene nametranscobalamin 1membrane spanning 4-domains A4A
SynonymsHC|TC-1|TC1|TCI4SPAN1|CD20-L1|CD20L1|HDCME31P|MS4A4|MS4A7
Cytomap('TCN1')('MS4A4A')

11q12.1

11q12.2

Type of geneprotein-codingprotein-coding
Descriptiontranscobalamin-1haptocorinhaptocorrinprotein Rtranscobalamin I (vitamin B12 binding protein, R binder family)membrane-spanning 4-domains subfamily A member 4ACD20 antigen-like 1Fc epsilon receptor beta subunit homologepididymis secretory sperm binding proteinfour-span transmembrane protein 1membrane-spanning 4-domains, subfamily A, member 4
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000257264, ENST00000532419, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 2 X 4=32
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TCN1 [Title/Abstract] AND MS4A4A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTCN1(59622125)-MS4A4A(60059698), # samples:2
Anticipated loss of major functional domain due to fusion event.TCN1-MS4A4A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TCN1-MS4A4A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TCN1-MS4A4A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TCN1-MS4A4A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TCN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across MS4A4A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-S5-AA26-01ATCN1chr11

59622125

-MS4A4Achr11

60059698

+


Top

Fusion Gene ORF analysis for TCN1-MS4A4A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000257264ENST00000355131TCN1chr11

59622125

-MS4A4Achr11

60059698

+
5CDS-5UTRENST00000257264ENST00000395016TCN1chr11

59622125

-MS4A4Achr11

60059698

+
In-frameENST00000257264ENST00000337908TCN1chr11

59622125

-MS4A4Achr11

60059698

+
In-frameENST00000257264ENST00000532114TCN1chr11

59622125

-MS4A4Achr11

60059698

+
intron-3CDSENST00000532419ENST00000337908TCN1chr11

59622125

-MS4A4Achr11

60059698

+
intron-3CDSENST00000532419ENST00000532114TCN1chr11

59622125

-MS4A4Achr11

60059698

+
intron-5UTRENST00000532419ENST00000355131TCN1chr11

59622125

-MS4A4Achr11

60059698

+
intron-5UTRENST00000532419ENST00000395016TCN1chr11

59622125

-MS4A4Achr11

60059698

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000257264TCN1chr1159622125-ENST00000532114MS4A4Achr1160059698+174812261051745546
ENST00000257264TCN1chr1159622125-ENST00000337908MS4A4Achr1160059698+269912261051904599

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000257264ENST00000532114TCN1chr1159622125-MS4A4Achr1160059698+0.000511390.9994886
ENST00000257264ENST00000337908TCN1chr1159622125-MS4A4Achr1160059698+0.0003916870.99960834

Top

Fusion Genomic Features for TCN1-MS4A4A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TCN1chr1159622124-MS4A4Achr1160059697+0.0090077310.9909923
TCN1chr1159622124-MS4A4Achr1160059697+0.0090077310.9909923

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for TCN1-MS4A4A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:59622125/chr11:60059698)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTCN1chr11:59622125chr11:60059698ENST00000257264-79142_146373434.0RegionCyanocob(III)alamin binding
HgeneTCN1chr11:59622125chr11:60059698ENST00000257264-7924_310373434.0RegionNote=Globular N-terminal alpha domain
HgeneTCN1chr11:59622125chr11:60059698ENST00000257264-79311_332373434.0RegionNote=Flexible linker
TgeneMS4A4Achr11:59622125chr11:60059698ENST0000033790807120_13713240.0Topological domainCytoplasmic
TgeneMS4A4Achr11:59622125chr11:60059698ENST0000033790807159_17913240.0Topological domainExtracellular
TgeneMS4A4Achr11:59622125chr11:60059698ENST0000033790807201_23913240.0Topological domainCytoplasmic
TgeneMS4A4Achr11:59622125chr11:60059698ENST000003379080786_9813240.0Topological domainExtracellular
TgeneMS4A4Achr11:59622125chr11:60059698ENST0000035513118120_1370221.0Topological domainCytoplasmic
TgeneMS4A4Achr11:59622125chr11:60059698ENST0000035513118159_1790221.0Topological domainExtracellular
TgeneMS4A4Achr11:59622125chr11:60059698ENST00000355131181_640221.0Topological domainCytoplasmic
TgeneMS4A4Achr11:59622125chr11:60059698ENST0000035513118201_2390221.0Topological domainCytoplasmic
TgeneMS4A4Achr11:59622125chr11:60059698ENST000003551311886_980221.0Topological domainExtracellular
TgeneMS4A4Achr11:59622125chr11:60059698ENST0000039501607120_1370221.0Topological domainCytoplasmic
TgeneMS4A4Achr11:59622125chr11:60059698ENST0000039501607159_1790221.0Topological domainExtracellular
TgeneMS4A4Achr11:59622125chr11:60059698ENST00000395016071_640221.0Topological domainCytoplasmic
TgeneMS4A4Achr11:59622125chr11:60059698ENST0000039501607201_2390221.0Topological domainCytoplasmic
TgeneMS4A4Achr11:59622125chr11:60059698ENST000003950160786_980221.0Topological domainExtracellular
TgeneMS4A4Achr11:59622125chr11:60059698ENST0000053211406120_13713187.0Topological domainCytoplasmic
TgeneMS4A4Achr11:59622125chr11:60059698ENST0000053211406159_17913187.0Topological domainExtracellular
TgeneMS4A4Achr11:59622125chr11:60059698ENST0000053211406201_23913187.0Topological domainCytoplasmic
TgeneMS4A4Achr11:59622125chr11:60059698ENST000005321140686_9813187.0Topological domainExtracellular
TgeneMS4A4Achr11:59622125chr11:60059698ENST0000033790807138_15813240.0TransmembraneHelical
TgeneMS4A4Achr11:59622125chr11:60059698ENST0000033790807180_20013240.0TransmembraneHelical
TgeneMS4A4Achr11:59622125chr11:60059698ENST000003379080765_8513240.0TransmembraneHelical
TgeneMS4A4Achr11:59622125chr11:60059698ENST000003379080799_11913240.0TransmembraneHelical
TgeneMS4A4Achr11:59622125chr11:60059698ENST0000035513118138_1580221.0TransmembraneHelical
TgeneMS4A4Achr11:59622125chr11:60059698ENST0000035513118180_2000221.0TransmembraneHelical
TgeneMS4A4Achr11:59622125chr11:60059698ENST000003551311865_850221.0TransmembraneHelical
TgeneMS4A4Achr11:59622125chr11:60059698ENST000003551311899_1190221.0TransmembraneHelical
TgeneMS4A4Achr11:59622125chr11:60059698ENST0000039501607138_1580221.0TransmembraneHelical
TgeneMS4A4Achr11:59622125chr11:60059698ENST0000039501607180_2000221.0TransmembraneHelical
TgeneMS4A4Achr11:59622125chr11:60059698ENST000003950160765_850221.0TransmembraneHelical
TgeneMS4A4Achr11:59622125chr11:60059698ENST000003950160799_1190221.0TransmembraneHelical
TgeneMS4A4Achr11:59622125chr11:60059698ENST0000053211406138_15813187.0TransmembraneHelical
TgeneMS4A4Achr11:59622125chr11:60059698ENST0000053211406180_20013187.0TransmembraneHelical
TgeneMS4A4Achr11:59622125chr11:60059698ENST000005321140665_8513187.0TransmembraneHelical
TgeneMS4A4Achr11:59622125chr11:60059698ENST000005321140699_11913187.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTCN1chr11:59622125chr11:60059698ENST00000257264-79333_433373434.0RegionNote=Globular C-terminal beta domain
HgeneTCN1chr11:59622125chr11:60059698ENST00000257264-79385_386373434.0RegionCyanocob(III)alamin binding
HgeneTCN1chr11:59622125chr11:60059698ENST00000257264-79402_404373434.0RegionCyanocob(III)alamin binding
TgeneMS4A4Achr11:59622125chr11:60059698ENST00000337908071_6413240.0Topological domainCytoplasmic
TgeneMS4A4Achr11:59622125chr11:60059698ENST00000532114061_6413187.0Topological domainCytoplasmic


Top

Fusion Gene Sequence for TCN1-MS4A4A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>89847_89847_1_TCN1-MS4A4A_TCN1_chr11_59622125_ENST00000257264_MS4A4A_chr11_60059698_ENST00000337908_length(transcript)=2699nt_BP=1226nt
GAAAAGAGGCTGAGGCAACCTGAAGGAGGAGCTCTCATTACCTTCTGCCCATCACTTAATAAATAGCCAGCCAATTCATCAACATTCTGG
TACACTGTTGGAGAGATGAGACAGTCACACCAGCTGCCCCTAGTGGGGCTCTTACTGTTTTCTTTTATTCCAAGCCAACTATGCGAGATT
TGTGAGGTAAGTGAAGAAAACTACATCCGCCTAAAACCTCTGTTGAATACAATGATCCAGTCAAACTATAACAGGGGAACCAGCGCTGTC
AATGTTGTGTTGTCCCTCAAACTTGTTGGAATCCAGATCCAAACCCTGATGCAAAAGATGATCCAACAAATCAAATACAATGTGAAAAGC
AGATTGTCAGATGTAAGCTCGGGAGAGCTTGCCTTGATTATACTGGCTTTGGGAGTATGTCGTAACGCTGAGGAAAACTTAATATATGAT
TACCACCTGATCGACAAGCTAGAAAATAAATTCCAAGCAGAAATTGAAAATATGGAAGCACACAATGGCACTCCCCTGACTAACTACTAC
CAGCTCAGCCTGGACGTTTTGGCCTTGTGTCTGTTCAATGGGAACTACTCAACCGCCGAAGTTGTCAACCACTTCACTCCTGAAAATAAA
AACTATTATTTTGGTAGCCAGTTCTCAGTAGATACTGGTGCAATGGCTGTCCTGGCTCTGACCTGTGTGAAGAAGAGTCTAATAAATGGG
CAGATCAAAGCAGATGAAGGCAGTTTAAAGAACATCAGTATTTATACAAAGTCACTGGTAGAAAAGATTCTGTCTGAGAAAAAAGAAAAT
GGTCTCATTGGAAACACATTTAGCACAGGAGAAGCCATGCAGGCCCTCTTTGTATCATCAGACTATTATAATGAAAATGACTGGAATTGC
CAACAAACTCTGAATACAGTGCTCACGGAAATTTCTCAAGGAGCATTCAGCAATCCAAACGCTGCAGCCCAGGTCTTACCTGCCCTGATG
GGAAAGACCTTCTTGGATATTAACAAAGACTCTTCTTGCGTCTCTGCTTCAGGTAACTTCAACATCTCCGCTGATGAGCCTATAACTGTG
ACACCTCCTGACTCACAATCATATATCTCCGTCAATTACTCTGTGAGAATCAATGAAACATATTTCACCAATGTCACTGTGCTAAATGGT
TCTGTCTTCCTCAGTGTGATGGAGAAAGCCCAGAAAATGAATGATACTATATTTGGCACCTTTTCTGCTGCCATGACAACCATGCAAGGA
ATGGAACAGGCCATGCCAGGGGCTGGCCCTGGTGTGCCCCAGCTGGGAAACATGGCTGTCATACATTCACATCTGTGGAAAGGATTGCAA
GAGAAGTTCTTGAAGGGAGAACCCAAAGTCCTTGGGGTTGTGCAGATTCTGACTGCCCTGATGAGCCTTAGCATGGGAATAACAATGATG
TGTATGGCATCTAATACTTATGGAAGTAACCCTATTTCCGTGTATATCGGGTACACAATTTGGGGGTCAGTAATGTTTATTATTTCAGGA
TCCTTGTCAATTGCAGCAGGAATTAGAACTACAAAAGGCCTGGTCCGAGGTAGTCTAGGAATGAATATCACCAGCTCTGTACTGGCTGCA
TCAGGGATCTTAATCAACACATTTAGCTTGGCGTTTTATTCATTCCATCACCCTTACTGTAACTACTATGGCAACTCAAATAATTGTCAT
GGGACTATGTCCATCTTAATGGGTCTGGATGGCATGGTGCTCCTCCTAAGTGTGCTGGAATTCTGCATTGCTGTGTCCCTCTCTGCCTTT
GGATGTAAAGTGCTCTGTTGTACCCCTGGTGGGGTTGTGTTAATTCTGCCATCACATTCTCACATGGCAGAAACAGCATCTCCCACACCA
CTTAATGAGGTTTGAGGCCACCAAAAGATCAACAGACAAATGCTCCAGAAATCTATGCTGACTGTGACACAAGAGCCTCACATGAGAAAT
TACCAGTATCCAACTTCGATACTGATAGACTTGTTGATATTATTATTATATGTAATCCAATTATGAACTGTGTGTGTATAGAGAGATAAT
AAATTCAAAATTATGTTCTCATTTTTTTCCCTGGAACTCAATAACTCATTTCACTGGCTCTTTATCGAGAGTACTAGAAGTTAAATTAAT
AAATAATGCATTTAATGAGGCAACAGCACTTGAAAGTTTTTCATTCATCATAAGAACTTTATATAAAGGCATTACATTGGCAAATAAGGT
TTGGAAGCAGAAGAGCAAAAAAAAGATATTGTTAAAATGAGGCCTCCATGCAAAACACATACTTCCCTCCCATTTATTTAACTTTTTTTT
TCTCCTACCTATGGGGACCAAAGTGCTTTTTCCTTCAGGAAGTGGAGATGCATGGCCATCTCCCCCTCCCTTTTTCCTTCTCCTGCTTTT
CTTTCCCCATAGAAAGTACCTTGAAGTAGCACAGCCCGTCCTTGCATGTGCACGAGCTATCATTTGAGTAAAAGTATACATGGAGTAAAA
ATCATATTAAGCATCAGATTCAACTTATATTTTCTATTTCATCTTCTTCCTTTCCCTTCTCCCACCTTCTACTGGGCATAATTATATCTT
AATCATATATGGAAATGTGCAACATATGGTATTTGTTAAATACGTTTGTTTTTATTGCAGAGCAAAAATAAATCAAATTAGAAGCAATA

>89847_89847_1_TCN1-MS4A4A_TCN1_chr11_59622125_ENST00000257264_MS4A4A_chr11_60059698_ENST00000337908_length(amino acids)=599AA_BP=374
MRQSHQLPLVGLLLFSFIPSQLCEICEVSEENYIRLKPLLNTMIQSNYNRGTSAVNVVLSLKLVGIQIQTLMQKMIQQIKYNVKSRLSDV
SSGELALIILALGVCRNAEENLIYDYHLIDKLENKFQAEIENMEAHNGTPLTNYYQLSLDVLALCLFNGNYSTAEVVNHFTPENKNYYFG
SQFSVDTGAMAVLALTCVKKSLINGQIKADEGSLKNISIYTKSLVEKILSEKKENGLIGNTFSTGEAMQALFVSSDYYNENDWNCQQTLN
TVLTEISQGAFSNPNAAAQVLPALMGKTFLDINKDSSCVSASGNFNISADEPITVTPPDSQSYISVNYSVRINETYFTNVTVLNGSVFLS
VMEKAQKMNDTIFGTFSAAMTTMQGMEQAMPGAGPGVPQLGNMAVIHSHLWKGLQEKFLKGEPKVLGVVQILTALMSLSMGITMMCMASN
TYGSNPISVYIGYTIWGSVMFIISGSLSIAAGIRTTKGLVRGSLGMNITSSVLAASGILINTFSLAFYSFHHPYCNYYGNSNNCHGTMSI
LMGLDGMVLLLSVLEFCIAVSLSAFGCKVLCCTPGGVVLILPSHSHMAETASPTPLNEV

--------------------------------------------------------------
>89847_89847_2_TCN1-MS4A4A_TCN1_chr11_59622125_ENST00000257264_MS4A4A_chr11_60059698_ENST00000532114_length(transcript)=1748nt_BP=1226nt
GAAAAGAGGCTGAGGCAACCTGAAGGAGGAGCTCTCATTACCTTCTGCCCATCACTTAATAAATAGCCAGCCAATTCATCAACATTCTGG
TACACTGTTGGAGAGATGAGACAGTCACACCAGCTGCCCCTAGTGGGGCTCTTACTGTTTTCTTTTATTCCAAGCCAACTATGCGAGATT
TGTGAGGTAAGTGAAGAAAACTACATCCGCCTAAAACCTCTGTTGAATACAATGATCCAGTCAAACTATAACAGGGGAACCAGCGCTGTC
AATGTTGTGTTGTCCCTCAAACTTGTTGGAATCCAGATCCAAACCCTGATGCAAAAGATGATCCAACAAATCAAATACAATGTGAAAAGC
AGATTGTCAGATGTAAGCTCGGGAGAGCTTGCCTTGATTATACTGGCTTTGGGAGTATGTCGTAACGCTGAGGAAAACTTAATATATGAT
TACCACCTGATCGACAAGCTAGAAAATAAATTCCAAGCAGAAATTGAAAATATGGAAGCACACAATGGCACTCCCCTGACTAACTACTAC
CAGCTCAGCCTGGACGTTTTGGCCTTGTGTCTGTTCAATGGGAACTACTCAACCGCCGAAGTTGTCAACCACTTCACTCCTGAAAATAAA
AACTATTATTTTGGTAGCCAGTTCTCAGTAGATACTGGTGCAATGGCTGTCCTGGCTCTGACCTGTGTGAAGAAGAGTCTAATAAATGGG
CAGATCAAAGCAGATGAAGGCAGTTTAAAGAACATCAGTATTTATACAAAGTCACTGGTAGAAAAGATTCTGTCTGAGAAAAAAGAAAAT
GGTCTCATTGGAAACACATTTAGCACAGGAGAAGCCATGCAGGCCCTCTTTGTATCATCAGACTATTATAATGAAAATGACTGGAATTGC
CAACAAACTCTGAATACAGTGCTCACGGAAATTTCTCAAGGAGCATTCAGCAATCCAAACGCTGCAGCCCAGGTCTTACCTGCCCTGATG
GGAAAGACCTTCTTGGATATTAACAAAGACTCTTCTTGCGTCTCTGCTTCAGGTAACTTCAACATCTCCGCTGATGAGCCTATAACTGTG
ACACCTCCTGACTCACAATCATATATCTCCGTCAATTACTCTGTGAGAATCAATGAAACATATTTCACCAATGTCACTGTGCTAAATGGT
TCTGTCTTCCTCAGTGTGATGGAGAAAGCCCAGAAAATGAATGATACTATATTTGGCACCTTTTCTGCTGCCATGACAACCATGCAAGGA
ATGGAACAGGCCATGCCAGGGGCTGGCCCTGGTGTGCCCCAGCTGGGAAACATGGCTGTCATACATTCACATCTGTGGAAAGGATTGCAA
GAGAAGTTCTTGAAGGGAGAACCCAAAGTCCTTGGGGTTGTGCAGATTCTGACTGCCCTGATGAGCCTTAGCATGGGAATAACAATGATG
TGTATGGCATCTAATACTTATGGAAGTAACCCTATTTCCGTGTATATCGGGTACACAATTTGGGGGTCAGTAATGTTTATTATTTCAGGA
TCCTTGTCAATTGCAGCAGGAATTAGAACTACAAAAGGCCTGGGTCTGGATGGCATGGTGCTCCTCCTAAGTGTGCTGGAATTCTGCATT
GCTGTGTCCCTCTCTGCCTTTGGATGTAAAGTGCTCTGTTGTACCCCTGGTGGGGTTGTGTTAATTCTGCCATCACATTCTCACATGGCA
GAAACAGCATCTCCCACACCACTTAATGAGGTTTGAGG

>89847_89847_2_TCN1-MS4A4A_TCN1_chr11_59622125_ENST00000257264_MS4A4A_chr11_60059698_ENST00000532114_length(amino acids)=546AA_BP=374
MRQSHQLPLVGLLLFSFIPSQLCEICEVSEENYIRLKPLLNTMIQSNYNRGTSAVNVVLSLKLVGIQIQTLMQKMIQQIKYNVKSRLSDV
SSGELALIILALGVCRNAEENLIYDYHLIDKLENKFQAEIENMEAHNGTPLTNYYQLSLDVLALCLFNGNYSTAEVVNHFTPENKNYYFG
SQFSVDTGAMAVLALTCVKKSLINGQIKADEGSLKNISIYTKSLVEKILSEKKENGLIGNTFSTGEAMQALFVSSDYYNENDWNCQQTLN
TVLTEISQGAFSNPNAAAQVLPALMGKTFLDINKDSSCVSASGNFNISADEPITVTPPDSQSYISVNYSVRINETYFTNVTVLNGSVFLS
VMEKAQKMNDTIFGTFSAAMTTMQGMEQAMPGAGPGVPQLGNMAVIHSHLWKGLQEKFLKGEPKVLGVVQILTALMSLSMGITMMCMASN
TYGSNPISVYIGYTIWGSVMFIISGSLSIAAGIRTTKGLGLDGMVLLLSVLEFCIAVSLSAFGCKVLCCTPGGVVLILPSHSHMAETASP
TPLNEV

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for TCN1-MS4A4A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for TCN1-MS4A4A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for TCN1-MS4A4A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTCN1C0002888Anemia, Megaloblastic1CTD_human
TgeneC0002395Alzheimer's Disease1CTD_human
TgeneC0011265Presenile dementia1CTD_human
TgeneC0087031Juvenile-Onset Still Disease1CTD_human
TgeneC0276496Familial Alzheimer Disease (FAD)1CTD_human
TgeneC0494463Alzheimer Disease, Late Onset1CTD_human
TgeneC0546126Acute Confusional Senile Dementia1CTD_human
TgeneC0750900Alzheimer's Disease, Focal Onset1CTD_human
TgeneC0750901Alzheimer Disease, Early Onset1CTD_human
TgeneC3495559Juvenile arthritis1CTD_human
TgeneC3714758Juvenile psoriatic arthritis1CTD_human
TgeneC4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
TgeneC4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human