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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:BUB1B-PCM1 (FusionGDB2 ID:HG701TG5108) |
Fusion Gene Summary for BUB1B-PCM1 |
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Fusion gene information | Fusion gene name: BUB1B-PCM1 | Fusion gene ID: hg701tg5108 | Hgene | Tgene | Gene symbol | BUB1B | PCM1 | Gene ID | 701 | 5108 |
Gene name | BUB1 mitotic checkpoint serine/threonine kinase B | pericentriolar material 1 | |
Synonyms | BUB1beta|BUBR1|Bub1A|MAD3L|MVA1|SSK1|hBUBR1 | PTC4|RET/PCM-1 | |
Cytomap | ('BUB1B')('PCM1') 15q15.1 | 8p22 | |
Type of gene | protein-coding | protein-coding | |
Description | mitotic checkpoint serine/threonine-protein kinase BUB1 betaBUB1B, mitotic checkpoint serine/threonine kinaseMAD3/BUB1-related protein kinasebudding uninhibited by benzimidazoles 1 homolog betamitotic checkpoint kinase MAD3L | pericentriolar material 1 proteinPCM-1hPCM-1pericentriolar material 1, PCM1 | |
Modification date | 20200313 | 20200327 | |
UniProtAcc | . | Q15154 | |
Ensembl transtripts involved in fusion gene | ENST00000560120, ENST00000287598, ENST00000412359, | ||
Fusion gene scores | * DoF score | 5 X 6 X 5=150 | 10 X 14 X 6=840 |
# samples | 12 | 13 | |
** MAII score | log2(12/150*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/840*10)=-2.69187770463767 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: BUB1B [Title/Abstract] AND PCM1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | BUB1B(40468874)-PCM1(17842956), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. | BUB1B-PCM1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. BUB1B-PCM1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. BUB1B-PCM1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. BUB1B-PCM1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. BUB1B-PCM1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | LUSC | TCGA-O2-A5IB-01A | BUB1B | chr15 | 40462882 | - | PCM1 | chr8 | 17842956 | + |
ChimerDB4 | LUSC | TCGA-O2-A5IB-01A | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842956 | + |
ChimerDB4 | LUSC | TCGA-O2-A5IB | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17840742 | + |
ChimerDB4 | LUSC | TCGA-O2-A5IB | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842956 | + |
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Fusion Gene ORF analysis for BUB1B-PCM1 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000560120 | ENST00000325083 | BUB1B | chr15 | 40462882 | - | PCM1 | chr8 | 17842956 | + |
3UTR-3CDS | ENST00000560120 | ENST00000519253 | BUB1B | chr15 | 40462882 | - | PCM1 | chr8 | 17842956 | + |
3UTR-3CDS | ENST00000560120 | ENST00000524226 | BUB1B | chr15 | 40462882 | - | PCM1 | chr8 | 17842956 | + |
3UTR-intron | ENST00000560120 | ENST00000327578 | BUB1B | chr15 | 40462882 | - | PCM1 | chr8 | 17842956 | + |
3UTR-intron | ENST00000560120 | ENST00000518537 | BUB1B | chr15 | 40462882 | - | PCM1 | chr8 | 17842956 | + |
3UTR-intron | ENST00000560120 | ENST00000518936 | BUB1B | chr15 | 40462882 | - | PCM1 | chr8 | 17842956 | + |
5CDS-intron | ENST00000287598 | ENST00000325083 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17840742 | + |
5CDS-intron | ENST00000287598 | ENST00000327578 | BUB1B | chr15 | 40462882 | - | PCM1 | chr8 | 17842956 | + |
5CDS-intron | ENST00000287598 | ENST00000327578 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842956 | + |
5CDS-intron | ENST00000287598 | ENST00000327578 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17840742 | + |
5CDS-intron | ENST00000287598 | ENST00000518537 | BUB1B | chr15 | 40462882 | - | PCM1 | chr8 | 17842956 | + |
5CDS-intron | ENST00000287598 | ENST00000518537 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842956 | + |
5CDS-intron | ENST00000287598 | ENST00000518537 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17840742 | + |
5CDS-intron | ENST00000287598 | ENST00000518936 | BUB1B | chr15 | 40462882 | - | PCM1 | chr8 | 17842956 | + |
5CDS-intron | ENST00000287598 | ENST00000518936 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842956 | + |
5CDS-intron | ENST00000287598 | ENST00000518936 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17840742 | + |
5CDS-intron | ENST00000287598 | ENST00000519253 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17840742 | + |
5CDS-intron | ENST00000287598 | ENST00000524226 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17840742 | + |
5CDS-intron | ENST00000412359 | ENST00000325083 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17840742 | + |
5CDS-intron | ENST00000412359 | ENST00000327578 | BUB1B | chr15 | 40462882 | - | PCM1 | chr8 | 17842956 | + |
5CDS-intron | ENST00000412359 | ENST00000327578 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842956 | + |
5CDS-intron | ENST00000412359 | ENST00000327578 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17840742 | + |
5CDS-intron | ENST00000412359 | ENST00000518537 | BUB1B | chr15 | 40462882 | - | PCM1 | chr8 | 17842956 | + |
5CDS-intron | ENST00000412359 | ENST00000518537 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842956 | + |
5CDS-intron | ENST00000412359 | ENST00000518537 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17840742 | + |
5CDS-intron | ENST00000412359 | ENST00000518936 | BUB1B | chr15 | 40462882 | - | PCM1 | chr8 | 17842956 | + |
5CDS-intron | ENST00000412359 | ENST00000518936 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842956 | + |
5CDS-intron | ENST00000412359 | ENST00000518936 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17840742 | + |
5CDS-intron | ENST00000412359 | ENST00000519253 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17840742 | + |
5CDS-intron | ENST00000412359 | ENST00000524226 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17840742 | + |
Frame-shift | ENST00000287598 | ENST00000325083 | BUB1B | chr15 | 40462882 | - | PCM1 | chr8 | 17842956 | + |
Frame-shift | ENST00000287598 | ENST00000325083 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842956 | + |
Frame-shift | ENST00000287598 | ENST00000519253 | BUB1B | chr15 | 40462882 | - | PCM1 | chr8 | 17842956 | + |
Frame-shift | ENST00000287598 | ENST00000519253 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842956 | + |
Frame-shift | ENST00000287598 | ENST00000524226 | BUB1B | chr15 | 40462882 | - | PCM1 | chr8 | 17842956 | + |
Frame-shift | ENST00000287598 | ENST00000524226 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842956 | + |
Frame-shift | ENST00000412359 | ENST00000325083 | BUB1B | chr15 | 40462882 | - | PCM1 | chr8 | 17842956 | + |
Frame-shift | ENST00000412359 | ENST00000325083 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842956 | + |
Frame-shift | ENST00000412359 | ENST00000519253 | BUB1B | chr15 | 40462882 | - | PCM1 | chr8 | 17842956 | + |
Frame-shift | ENST00000412359 | ENST00000519253 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842956 | + |
Frame-shift | ENST00000412359 | ENST00000524226 | BUB1B | chr15 | 40462882 | - | PCM1 | chr8 | 17842956 | + |
Frame-shift | ENST00000412359 | ENST00000524226 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842956 | + |
intron-3CDS | ENST00000560120 | ENST00000325083 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842956 | + |
intron-3CDS | ENST00000560120 | ENST00000519253 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842956 | + |
intron-3CDS | ENST00000560120 | ENST00000524226 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842956 | + |
intron-intron | ENST00000560120 | ENST00000325083 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17840742 | + |
intron-intron | ENST00000560120 | ENST00000327578 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842956 | + |
intron-intron | ENST00000560120 | ENST00000327578 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17840742 | + |
intron-intron | ENST00000560120 | ENST00000518537 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842956 | + |
intron-intron | ENST00000560120 | ENST00000518537 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17840742 | + |
intron-intron | ENST00000560120 | ENST00000518936 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842956 | + |
intron-intron | ENST00000560120 | ENST00000518936 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17840742 | + |
intron-intron | ENST00000560120 | ENST00000519253 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17840742 | + |
intron-intron | ENST00000560120 | ENST00000524226 | BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17840742 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for BUB1B-PCM1 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17840741 | + | 0.000305947 | 0.9996941 |
BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842955 | + | 1.21E-05 | 0.99998784 |
BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842955 | + | 1.21E-05 | 0.99998784 |
BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17840741 | + | 0.000305947 | 0.9996941 |
BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842955 | + | 1.21E-05 | 0.99998784 |
BUB1B | chr15 | 40468874 | + | PCM1 | chr8 | 17842955 | + | 1.21E-05 | 0.99998784 |
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Fusion Protein Features for BUB1B-PCM1 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:40468874/:17842956) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | PCM1 |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Required for centrosome assembly and function (PubMed:12403812, PubMed:15659651, PubMed:16943179). Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2 (PubMed:12403812, PubMed:15659651). Required to anchor microtubules to the centrosome (PubMed:12403812, PubMed:15659651). Also involved in cilium biogenesis by recruiting the BBSome, a ciliary protein complex involved in cilium biogenesis, to the centriolar satellites (PubMed:20551181, PubMed:24121310, PubMed:27979967). {ECO:0000269|PubMed:12403812, ECO:0000269|PubMed:15659651, ECO:0000269|PubMed:16943179, ECO:0000269|PubMed:20551181, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:27979967}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for BUB1B-PCM1 |
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Fusion Gene PPI Analysis for BUB1B-PCM1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for BUB1B-PCM1 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for BUB1B-PCM1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | BUB1B | C1850343 | Mosaic variegated aneuploidy syndrome 1 | 6 | CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
Hgene | BUB1B | C0018273 | Growth Disorders | 1 | CTD_human |
Hgene | BUB1B | C0025958 | Microcephaly | 1 | CTD_human |
Hgene | BUB1B | C0027654 | Embryonal Neoplasm | 1 | CTD_human |
Hgene | BUB1B | C0027658 | Neoplasms, Germ Cell and Embryonal | 1 | CTD_human |
Hgene | BUB1B | C0205851 | Germ cell tumor | 1 | CTD_human |
Hgene | BUB1B | C0205852 | Neoplasms, Embryonal and Mixed | 1 | CTD_human |
Hgene | BUB1B | C0206656 | Embryonal Rhabdomyosarcoma | 1 | CTD_human |
Hgene | BUB1B | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
Hgene | BUB1B | C0740345 | Germ Cell Cancer | 1 | CTD_human |
Hgene | BUB1B | C0751364 | Cancer, Embryonal | 1 | CTD_human |
Hgene | BUB1B | C0751365 | Cancer, Embryonal and Mixed | 1 | CTD_human |
Hgene | BUB1B | C1864389 | PREMATURE CHROMATID SEPARATION TRAIT | 1 | CTD_human;UNIPROT |
Hgene | BUB1B | C1956147 | Microlissencephaly | 1 | CTD_human |
Hgene | BUB1B | C2239176 | Liver carcinoma | 1 | CTD_human |
Hgene | BUB1B | C2931286 | Warburton Anyane Yeboa syndrome | 1 | ORPHANET |
Hgene | BUB1B | C2931383 | Chromosomal mosaicism due to mitotic instability | 1 | CTD_human |
Hgene | BUB1B | C3853041 | Severe Congenital Microcephaly | 1 | CTD_human |
Tgene | C0036341 | Schizophrenia | 1 | CTD_human | |
Tgene | C0238463 | Papillary thyroid carcinoma | 1 | ORPHANET |