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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:C4A-SAPCD1 (FusionGDB2 ID:HG720TG401251)

Fusion Gene Summary for C4A-SAPCD1

Fusion gene summary

Fusion gene information	Fusion gene name: C4A-SAPCD1
	Fusion gene ID: hg720tg401251
		Hgene	Tgene
	Gene symbol	C4A	SAPCD1
	Gene ID	720	401251
	Gene name	complement C4A (Rodgers blood group)	suppressor APC domain containing 1
	Synonyms	C4\|C4A2\|C4A3\|C4A4\|C4A6\|C4AD\|C4S\|CO4\|CPAMD2\|RG	C6orf26\|NG23
	Cytomap	('C4A')('SAPCD1') 6p21.33	6p21.33
	Type of gene	protein-coding	protein-coding
	Description	complement C4-AC3 and PZP-like alpha-2-macroglobulin domain-containing protein 2C4A anaphylatoxinMHC class III region complementRodgers form of C4acidic C4acidic complement C4complement component 4A (Rodgers blood group)	suppressor APC domain-containing protein 1protein G7d
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000428956, ENST00000498271, ENST00000537134, ENST00000375295, ENST00000383325, ENST00000421274, ENST00000467948, ENST00000483562, ENST00000488693, ENST00000489963, ENST00000546746, ENST00000549812, ENST00000550297,
Fusion gene scores	* DoF score	3 X 12 X 4=144	2 X 1 X 1=2
	# samples	5	1
	** MAII score	log2(5/144*10)=-1.52606881166759 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(1/2*10)=2.32192809488736
Context	PubMed: C4A [Title/Abstract] AND SAPCD1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	C4A(31952185)-SAPCD1(31732213), # samples:1
Anticipated loss of major functional domain due to fusion event.	C4A-SAPCD1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. C4A-SAPCD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across C4A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SAPCD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-36-1581-01A	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+

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Fusion Gene ORF analysis for C4A-SAPCD1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000428956	ENST00000383205	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000428956	ENST00000425286	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000428956	ENST00000427166	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000428956	ENST00000436320	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000428956	ENST00000443153	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000428956	ENST00000447852	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000428956	ENST00000449857	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000428956	ENST00000449925	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000428956	ENST00000453534	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000428956	ENST00000457185	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000428956	ENST00000547662	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000428956	ENST00000548003	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000428956	ENST00000548987	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000428956	ENST00000551778	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000428956	ENST00000552302	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000498271	ENST00000383205	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000498271	ENST00000425286	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000498271	ENST00000427166	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000498271	ENST00000436320	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000498271	ENST00000443153	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000498271	ENST00000447852	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000498271	ENST00000449857	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000498271	ENST00000449925	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000498271	ENST00000453534	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000498271	ENST00000457185	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000498271	ENST00000547662	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000498271	ENST00000548003	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000498271	ENST00000548987	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000498271	ENST00000551778	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000498271	ENST00000552302	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000537134	ENST00000383205	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000537134	ENST00000425286	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000537134	ENST00000427166	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000537134	ENST00000436320	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000537134	ENST00000443153	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000537134	ENST00000447852	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000537134	ENST00000449857	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000537134	ENST00000449925	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000537134	ENST00000453534	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000537134	ENST00000457185	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000537134	ENST00000547662	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000537134	ENST00000548003	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000537134	ENST00000548987	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000537134	ENST00000551778	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
5CDS-intron	ENST00000537134	ENST00000552302	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
Frame-shift	ENST00000537134	ENST00000415669	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
Frame-shift	ENST00000537134	ENST00000425424	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
In-frame	ENST00000428956	ENST00000415669	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
In-frame	ENST00000428956	ENST00000425424	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
In-frame	ENST00000498271	ENST00000415669	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
In-frame	ENST00000498271	ENST00000425424	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-3CDS	ENST00000375295	ENST00000415669	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-3CDS	ENST00000375295	ENST00000425424	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-3CDS	ENST00000383325	ENST00000415669	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-3CDS	ENST00000383325	ENST00000425424	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-3CDS	ENST00000421274	ENST00000415669	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-3CDS	ENST00000421274	ENST00000425424	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-3CDS	ENST00000467948	ENST00000415669	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-3CDS	ENST00000467948	ENST00000425424	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-3CDS	ENST00000483562	ENST00000415669	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-3CDS	ENST00000483562	ENST00000425424	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-3CDS	ENST00000488693	ENST00000415669	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-3CDS	ENST00000488693	ENST00000425424	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-3CDS	ENST00000489963	ENST00000415669	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-3CDS	ENST00000489963	ENST00000425424	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-3CDS	ENST00000546746	ENST00000415669	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-3CDS	ENST00000546746	ENST00000425424	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-3CDS	ENST00000549812	ENST00000415669	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-3CDS	ENST00000549812	ENST00000425424	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-3CDS	ENST00000550297	ENST00000415669	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-3CDS	ENST00000550297	ENST00000425424	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000375295	ENST00000383205	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000375295	ENST00000425286	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000375295	ENST00000427166	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000375295	ENST00000436320	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000375295	ENST00000443153	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000375295	ENST00000447852	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000375295	ENST00000449857	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000375295	ENST00000449925	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000375295	ENST00000453534	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000375295	ENST00000457185	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000375295	ENST00000547662	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000375295	ENST00000548003	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000375295	ENST00000548987	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000375295	ENST00000551778	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000375295	ENST00000552302	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000383325	ENST00000383205	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000383325	ENST00000425286	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000383325	ENST00000427166	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000383325	ENST00000436320	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000383325	ENST00000443153	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000383325	ENST00000447852	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000383325	ENST00000449857	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000383325	ENST00000449925	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000383325	ENST00000453534	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000383325	ENST00000457185	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000383325	ENST00000547662	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000383325	ENST00000548003	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000383325	ENST00000548987	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000383325	ENST00000551778	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000383325	ENST00000552302	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000421274	ENST00000383205	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000421274	ENST00000425286	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000421274	ENST00000427166	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000421274	ENST00000436320	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000421274	ENST00000443153	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000421274	ENST00000447852	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000421274	ENST00000449857	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000421274	ENST00000449925	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000421274	ENST00000453534	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000421274	ENST00000457185	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000421274	ENST00000547662	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000421274	ENST00000548003	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000421274	ENST00000548987	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000421274	ENST00000551778	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000421274	ENST00000552302	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000467948	ENST00000383205	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000467948	ENST00000425286	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000467948	ENST00000427166	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000467948	ENST00000436320	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000467948	ENST00000443153	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000467948	ENST00000447852	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000467948	ENST00000449857	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000467948	ENST00000449925	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000467948	ENST00000453534	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000467948	ENST00000457185	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000467948	ENST00000547662	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000467948	ENST00000548003	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000467948	ENST00000548987	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000467948	ENST00000551778	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000467948	ENST00000552302	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000483562	ENST00000383205	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000483562	ENST00000425286	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000483562	ENST00000427166	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000483562	ENST00000436320	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000483562	ENST00000443153	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000483562	ENST00000447852	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000483562	ENST00000449857	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000483562	ENST00000449925	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000483562	ENST00000453534	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000483562	ENST00000457185	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000483562	ENST00000547662	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000483562	ENST00000548003	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000483562	ENST00000548987	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000483562	ENST00000551778	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000483562	ENST00000552302	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000488693	ENST00000383205	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000488693	ENST00000425286	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000488693	ENST00000427166	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000488693	ENST00000436320	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000488693	ENST00000443153	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000488693	ENST00000447852	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000488693	ENST00000449857	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000488693	ENST00000449925	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000488693	ENST00000453534	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000488693	ENST00000457185	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000488693	ENST00000547662	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000488693	ENST00000548003	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000488693	ENST00000548987	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000488693	ENST00000551778	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000488693	ENST00000552302	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000489963	ENST00000383205	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000489963	ENST00000425286	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000489963	ENST00000427166	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000489963	ENST00000436320	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000489963	ENST00000443153	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000489963	ENST00000447852	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000489963	ENST00000449857	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000489963	ENST00000449925	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000489963	ENST00000453534	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000489963	ENST00000457185	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000489963	ENST00000547662	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000489963	ENST00000548003	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000489963	ENST00000548987	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000489963	ENST00000551778	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000489963	ENST00000552302	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000546746	ENST00000383205	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000546746	ENST00000425286	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000546746	ENST00000427166	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000546746	ENST00000436320	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000546746	ENST00000443153	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000546746	ENST00000447852	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000546746	ENST00000449857	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000546746	ENST00000449925	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000546746	ENST00000453534	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000546746	ENST00000457185	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000546746	ENST00000547662	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000546746	ENST00000548003	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000546746	ENST00000548987	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000546746	ENST00000551778	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000546746	ENST00000552302	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000549812	ENST00000383205	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000549812	ENST00000425286	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000549812	ENST00000427166	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000549812	ENST00000436320	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000549812	ENST00000443153	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000549812	ENST00000447852	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000549812	ENST00000449857	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000549812	ENST00000449925	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000549812	ENST00000453534	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000549812	ENST00000457185	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000549812	ENST00000547662	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000549812	ENST00000548003	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000549812	ENST00000548987	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000549812	ENST00000551778	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000549812	ENST00000552302	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000550297	ENST00000383205	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000550297	ENST00000425286	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000550297	ENST00000427166	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000550297	ENST00000436320	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000550297	ENST00000443153	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000550297	ENST00000447852	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000550297	ENST00000449857	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000550297	ENST00000449925	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000550297	ENST00000453534	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000550297	ENST00000457185	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000550297	ENST00000547662	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000550297	ENST00000548003	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000550297	ENST00000548987	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000550297	ENST00000551778	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+
intron-intron	ENST00000550297	ENST00000552302	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000428956

C4A

chr6

31952185

ENST00000425424

SAPCD1

chr6

31732213

1539

1129

1322

417

ENST00000428956

C4A

chr6

31952185

ENST00000415669

SAPCD1

chr6

31732213

1545

1129

1322

417

ENST00000498271

C4A

chr6

31952185

ENST00000425424

SAPCD1

chr6

31732213

1495

1085

1278

417

ENST00000498271

C4A

chr6

31952185

ENST00000415669

SAPCD1

chr6

31732213

1501

1085

1278

417

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000428956	ENST00000425424	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+	0.006926249	0.9930737
ENST00000428956	ENST00000415669	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+	0.006773018	0.99322695
ENST00000498271	ENST00000425424	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+	0.006114005	0.99388605
ENST00000498271	ENST00000415669	C4A	chr6	31952185	+	SAPCD1	chr6	31732213	+	0.005942539	0.9940574

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Fusion Genomic Features for C4A-SAPCD1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
C4A	chr6	31952185	+	SAPCD1	chr6	31732212	+	0.000286213	0.9997137
C4A	chr6	31952185	+	SAPCD1	chr6	31732212	+	0.000286213	0.9997137

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for C4A-SAPCD1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:31952185/chr6:31732213)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

C4A

chr6:31952185

chr6:31732213

ENST00000383325

1595_1742

1745.0

Domain

NTR

Hgene

C4A

chr6:31952185

chr6:31732213

ENST00000383325

702_736

1745.0

Domain

Anaphylatoxin-like

Hgene

C4A

chr6:31952185

chr6:31732213

ENST00000421274

1595_1742

1745.0

Domain

NTR

Hgene

C4A

chr6:31952185

chr6:31732213

ENST00000421274

702_736

1745.0

Domain

Anaphylatoxin-like

Hgene

C4A

chr6:31952185

chr6:31732213

ENST00000428956

1595_1742

348

1745.0

Domain

NTR

Hgene

C4A

chr6:31952185

chr6:31732213

ENST00000428956

702_736

348

1745.0

Domain

Anaphylatoxin-like

Hgene

C4A

chr6:31952185

chr6:31732213

ENST00000498271

1595_1742

348

1699.0

Domain

NTR

Hgene

C4A

chr6:31952185

chr6:31732213

ENST00000498271

702_736

348

1699.0

Domain

Anaphylatoxin-like

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Fusion Gene Sequence for C4A-SAPCD1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>11762_11762_1_C4A-SAPCD1_C4A_chr6_31952185_ENST00000428956_SAPCD1_chr6_31732213_ENST00000415669_length(transcript)=1545nt_BP=1129nt
AGAGTCAACTCTGCCCCGAGGCCTAGCTTGGCCAGAAGGTAGCAGACAGACAGACGGATCTAACCTCTCTTGGATCCTCCAGCCATGAGG
CTGCTCTGGGGGCTGATCTGGGCATCCAGCTTCTTCACCTTATCTCTGCAGAAGCCCAGGTTGCTCTTGTTCTCTCCTTCTGTGGTTCAT
CTGGGGGTCCCCCTATCGGTGGGGGTGCAGCTCCAGGATGTGCCCCGAGGACAGGTAGTGAAAGGATCAGTGTTCCTGAGAAACCCATCT
CGTAATAATGTCCCCTGCTCCCCAAAGGTGGACTTCACCCTTAGCTCAGAAAGAGACTTCGCACTCCTCAGTCTCCAGGTGCCCTTGAAA
GATGCGAAGAGCTGTGGCCTCCATCAACTCCTCAGAGGCCCTGAGGTCCAGCTGGTGGCCCATTCGCCATGGCTAAAGGACTCTCTGTCC
AGAACGACAAACATCCAGGGTATCAACCTGCTCTTCTCCTCTCGCCGGGGGCACCTCTTTTTGCAGACGGACCAGCCCATTTACAACCCT
GGCCAGCGGGTTCGGTACCGGGTCTTTGCTCTGGATCAGAAGATGCGCCCGAGCACTGACACCATCACAGTCATGGTGGAGAACTCTCAC
GGCCTCCGCGTGCGGAAGAAGGAGGTGTACATGCCCTCGTCCATCTTCCAGGATGACTTTGTGATCCCAGACATCTCAGAGCCAGGGACC
TGGAAGATCTCAGCCCGATTCTCAGATGGCCTGGAATCCAACAGCAGCACCCAGTTTGAGGTGAAGAAATATGTCCTTCCCAACTTTGAG
GTGAAGATCACCCCTGGAAAGCCCTACATCCTGACGGTGCCAGGCCATCTTGATGAAATGCAGTTAGACATCCAGGCCAGGTACATCTAT
GGGAAGCCAGTGCAGGGGGTGGCATATGTGCGCTTTGGGCTCCTAGATGAGGATGGTAAGAAGACTTTCTTTCGGGGGCTGGAGAGTCAG
ACCAAGCTGGTGAATGGACAGAGCCACATTTCCCTCTCAAAGGCAGAGTTCCAGGACGCCCTGGAGAAGCTGAATATGGGCATTACTGAC
CTCCAGGGGCTGCGCCTCTACGTTGCTGCAGCCATCATTGAGTCTCCAGGAGTTGTCAAGGCAGCAGAAAGGAGTCACCCAGCCAAAGGA
GGAGATGGCTCAGCGGGGCTGCACCAAGGGGCCAAGAGGCCCTACCCGTGTCTAAACCCTCCTCTCACTCCCCTAAGCCTGGTGAAAGAG
TCAGAAGCCCCAGGCTCCTTTTTCTGTTTCTTAACTCAACAGCTAAAAAATGGCTCCAGGTAGTGAGTCAATGAAGTTCAGACATGTTGG
TGTAAAGTTTCTCCTCTGCTCCTGAAAACTTCATCTTCTTGGTGTCTCATGTCCTCATTCTCCCCTATATGACATGCAAAAACGATCTTT
CTTTGAAATCCCTCTGGGAAGAAGCATGTTTATTGAAACTGTCCTTCAGCCTTAAATACAAAAATAAAACTGAAACTGCTCCAGAAAGCA
GCTTTCTCCAAAAAT

>11762_11762_1_C4A-SAPCD1_C4A_chr6_31952185_ENST00000428956_SAPCD1_chr6_31732213_ENST00000415669_length(amino acids)=417AA_BP=352
MDPPAMRLLWGLIWASSFFTLSLQKPRLLLFSPSVVHLGVPLSVGVQLQDVPRGQVVKGSVFLRNPSRNNVPCSPKVDFTLSSERDFALL
SLQVPLKDAKSCGLHQLLRGPEVQLVAHSPWLKDSLSRTTNIQGINLLFSSRRGHLFLQTDQPIYNPGQRVRYRVFALDQKMRPSTDTIT
VMVENSHGLRVRKKEVYMPSSIFQDDFVIPDISEPGTWKISARFSDGLESNSSTQFEVKKYVLPNFEVKITPGKPYILTVPGHLDEMQLD
IQARYIYGKPVQGVAYVRFGLLDEDGKKTFFRGLESQTKLVNGQSHISLSKAEFQDALEKLNMGITDLQGLRLYVAAAIIESPGVVKAAE
RSHPAKGGDGSAGLHQGAKRPYPCLNPPLTPLSLVKESEAPGSFFCFLTQQLKNGSR

--------------------------------------------------------------
>11762_11762_2_C4A-SAPCD1_C4A_chr6_31952185_ENST00000428956_SAPCD1_chr6_31732213_ENST00000425424_length(transcript)=1539nt_BP=1129nt
AGAGTCAACTCTGCCCCGAGGCCTAGCTTGGCCAGAAGGTAGCAGACAGACAGACGGATCTAACCTCTCTTGGATCCTCCAGCCATGAGG
CTGCTCTGGGGGCTGATCTGGGCATCCAGCTTCTTCACCTTATCTCTGCAGAAGCCCAGGTTGCTCTTGTTCTCTCCTTCTGTGGTTCAT
CTGGGGGTCCCCCTATCGGTGGGGGTGCAGCTCCAGGATGTGCCCCGAGGACAGGTAGTGAAAGGATCAGTGTTCCTGAGAAACCCATCT
CGTAATAATGTCCCCTGCTCCCCAAAGGTGGACTTCACCCTTAGCTCAGAAAGAGACTTCGCACTCCTCAGTCTCCAGGTGCCCTTGAAA
GATGCGAAGAGCTGTGGCCTCCATCAACTCCTCAGAGGCCCTGAGGTCCAGCTGGTGGCCCATTCGCCATGGCTAAAGGACTCTCTGTCC
AGAACGACAAACATCCAGGGTATCAACCTGCTCTTCTCCTCTCGCCGGGGGCACCTCTTTTTGCAGACGGACCAGCCCATTTACAACCCT
GGCCAGCGGGTTCGGTACCGGGTCTTTGCTCTGGATCAGAAGATGCGCCCGAGCACTGACACCATCACAGTCATGGTGGAGAACTCTCAC
GGCCTCCGCGTGCGGAAGAAGGAGGTGTACATGCCCTCGTCCATCTTCCAGGATGACTTTGTGATCCCAGACATCTCAGAGCCAGGGACC
TGGAAGATCTCAGCCCGATTCTCAGATGGCCTGGAATCCAACAGCAGCACCCAGTTTGAGGTGAAGAAATATGTCCTTCCCAACTTTGAG
GTGAAGATCACCCCTGGAAAGCCCTACATCCTGACGGTGCCAGGCCATCTTGATGAAATGCAGTTAGACATCCAGGCCAGGTACATCTAT
GGGAAGCCAGTGCAGGGGGTGGCATATGTGCGCTTTGGGCTCCTAGATGAGGATGGTAAGAAGACTTTCTTTCGGGGGCTGGAGAGTCAG
ACCAAGCTGGTGAATGGACAGAGCCACATTTCCCTCTCAAAGGCAGAGTTCCAGGACGCCCTGGAGAAGCTGAATATGGGCATTACTGAC
CTCCAGGGGCTGCGCCTCTACGTTGCTGCAGCCATCATTGAGTCTCCAGGAGTTGTCAAGGCAGCAGAAAGGAGTCACCCAGCCAAAGGA
GGAGATGGCTCAGCGGGGCTGCACCAAGGGGCCAAGAGGCCCTACCCGTGTCTAAACCCTCCTCTCACTCCCCTAAGCCTGGTGAAAGAG
TCAGAAGCCCCAGGCTCCTTTTTCTGTTTCTTAACTCAACAGCTAAAAAATGGCTCCAGGTAGTGAGTCAATGAAGTTCAGACATGTTGG
TGTAAAGTTTCTCCTCTGCTCCTGAAAACTTCATCTTCTTGGTGTCTCATGTCCTCATTCTCCCCTATATGACATGCAAAAACGATCTTT
CTTTGAAATCCCTCTGGGAAGAAGCATGTTTATTGAAACTGTCCTTCAGCCTTAAATACAAAAATAAAACTGAAACTGCTCCAGAAAGCA
GCTTTCTCC

>11762_11762_2_C4A-SAPCD1_C4A_chr6_31952185_ENST00000428956_SAPCD1_chr6_31732213_ENST00000425424_length(amino acids)=417AA_BP=352
MDPPAMRLLWGLIWASSFFTLSLQKPRLLLFSPSVVHLGVPLSVGVQLQDVPRGQVVKGSVFLRNPSRNNVPCSPKVDFTLSSERDFALL
SLQVPLKDAKSCGLHQLLRGPEVQLVAHSPWLKDSLSRTTNIQGINLLFSSRRGHLFLQTDQPIYNPGQRVRYRVFALDQKMRPSTDTIT
VMVENSHGLRVRKKEVYMPSSIFQDDFVIPDISEPGTWKISARFSDGLESNSSTQFEVKKYVLPNFEVKITPGKPYILTVPGHLDEMQLD
IQARYIYGKPVQGVAYVRFGLLDEDGKKTFFRGLESQTKLVNGQSHISLSKAEFQDALEKLNMGITDLQGLRLYVAAAIIESPGVVKAAE
RSHPAKGGDGSAGLHQGAKRPYPCLNPPLTPLSLVKESEAPGSFFCFLTQQLKNGSR

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>11762_11762_3_C4A-SAPCD1_C4A_chr6_31952185_ENST00000498271_SAPCD1_chr6_31732213_ENST00000415669_length(transcript)=1501nt_BP=1085nt
GACAGACAGACGGATCTAACCTCTCTTGGATCCTCCAGCCATGAGGCTGCTCTGGGGGCTGATCTGGGCATCCAGCTTCTTCACCTTATC
TCTGCAGAAGCCCAGGTTGCTCTTGTTCTCTCCTTCTGTGGTTCATCTGGGGGTCCCCCTATCGGTGGGGGTGCAGCTCCAGGATGTGCC
CCGAGGACAGGTAGTGAAAGGATCAGTGTTCCTGAGAAACCCATCTCGTAATAATGTCCCCTGCTCCCCAAAGGTGGACTTCACCCTTAG
CTCAGAAAGAGACTTCGCACTCCTCAGTCTCCAGGTGCCCTTGAAAGATGCGAAGAGCTGTGGCCTCCATCAACTCCTCAGAGGCCCTGA
GGTCCAGCTGGTGGCCCATTCGCCATGGCTAAAGGACTCTCTGTCCAGAACGACAAACATCCAGGGTATCAACCTGCTCTTCTCCTCTCG
CCGGGGGCACCTCTTTTTGCAGACGGACCAGCCCATTTACAACCCTGGCCAGCGGGTTCGGTACCGGGTCTTTGCTCTGGATCAGAAGAT
GCGCCCGAGCACTGACACCATCACAGTCATGGTGGAGAACTCTCACGGCCTCCGCGTGCGGAAGAAGGAGGTGTACATGCCCTCGTCCAT
CTTCCAGGATGACTTTGTGATCCCAGACATCTCAGAGCCAGGGACCTGGAAGATCTCAGCCCGATTCTCAGATGGCCTGGAATCCAACAG
CAGCACCCAGTTTGAGGTGAAGAAATATGTCCTTCCCAACTTTGAGGTGAAGATCACCCCTGGAAAGCCCTACATCCTGACGGTGCCAGG
CCATCTTGATGAAATGCAGTTAGACATCCAGGCCAGGTACATCTATGGGAAGCCAGTGCAGGGGGTGGCATATGTGCGCTTTGGGCTCCT
AGATGAGGATGGTAAGAAGACTTTCTTTCGGGGGCTGGAGAGTCAGACCAAGCTGGTGAATGGACAGAGCCACATTTCCCTCTCAAAGGC
AGAGTTCCAGGACGCCCTGGAGAAGCTGAATATGGGCATTACTGACCTCCAGGGGCTGCGCCTCTACGTTGCTGCAGCCATCATTGAGTC
TCCAGGAGTTGTCAAGGCAGCAGAAAGGAGTCACCCAGCCAAAGGAGGAGATGGCTCAGCGGGGCTGCACCAAGGGGCCAAGAGGCCCTA
CCCGTGTCTAAACCCTCCTCTCACTCCCCTAAGCCTGGTGAAAGAGTCAGAAGCCCCAGGCTCCTTTTTCTGTTTCTTAACTCAACAGCT
AAAAAATGGCTCCAGGTAGTGAGTCAATGAAGTTCAGACATGTTGGTGTAAAGTTTCTCCTCTGCTCCTGAAAACTTCATCTTCTTGGTG
TCTCATGTCCTCATTCTCCCCTATATGACATGCAAAAACGATCTTTCTTTGAAATCCCTCTGGGAAGAAGCATGTTTATTGAAACTGTCC
TTCAGCCTTAAATACAAAAATAAAACTGAAACTGCTCCAGAAAGCAGCTTTCTCCAAAAAT

>11762_11762_3_C4A-SAPCD1_C4A_chr6_31952185_ENST00000498271_SAPCD1_chr6_31732213_ENST00000415669_length(amino acids)=417AA_BP=352
MDPPAMRLLWGLIWASSFFTLSLQKPRLLLFSPSVVHLGVPLSVGVQLQDVPRGQVVKGSVFLRNPSRNNVPCSPKVDFTLSSERDFALL
SLQVPLKDAKSCGLHQLLRGPEVQLVAHSPWLKDSLSRTTNIQGINLLFSSRRGHLFLQTDQPIYNPGQRVRYRVFALDQKMRPSTDTIT
VMVENSHGLRVRKKEVYMPSSIFQDDFVIPDISEPGTWKISARFSDGLESNSSTQFEVKKYVLPNFEVKITPGKPYILTVPGHLDEMQLD
IQARYIYGKPVQGVAYVRFGLLDEDGKKTFFRGLESQTKLVNGQSHISLSKAEFQDALEKLNMGITDLQGLRLYVAAAIIESPGVVKAAE
RSHPAKGGDGSAGLHQGAKRPYPCLNPPLTPLSLVKESEAPGSFFCFLTQQLKNGSR

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>11762_11762_4_C4A-SAPCD1_C4A_chr6_31952185_ENST00000498271_SAPCD1_chr6_31732213_ENST00000425424_length(transcript)=1495nt_BP=1085nt
GACAGACAGACGGATCTAACCTCTCTTGGATCCTCCAGCCATGAGGCTGCTCTGGGGGCTGATCTGGGCATCCAGCTTCTTCACCTTATC
TCTGCAGAAGCCCAGGTTGCTCTTGTTCTCTCCTTCTGTGGTTCATCTGGGGGTCCCCCTATCGGTGGGGGTGCAGCTCCAGGATGTGCC
CCGAGGACAGGTAGTGAAAGGATCAGTGTTCCTGAGAAACCCATCTCGTAATAATGTCCCCTGCTCCCCAAAGGTGGACTTCACCCTTAG
CTCAGAAAGAGACTTCGCACTCCTCAGTCTCCAGGTGCCCTTGAAAGATGCGAAGAGCTGTGGCCTCCATCAACTCCTCAGAGGCCCTGA
GGTCCAGCTGGTGGCCCATTCGCCATGGCTAAAGGACTCTCTGTCCAGAACGACAAACATCCAGGGTATCAACCTGCTCTTCTCCTCTCG
CCGGGGGCACCTCTTTTTGCAGACGGACCAGCCCATTTACAACCCTGGCCAGCGGGTTCGGTACCGGGTCTTTGCTCTGGATCAGAAGAT
GCGCCCGAGCACTGACACCATCACAGTCATGGTGGAGAACTCTCACGGCCTCCGCGTGCGGAAGAAGGAGGTGTACATGCCCTCGTCCAT
CTTCCAGGATGACTTTGTGATCCCAGACATCTCAGAGCCAGGGACCTGGAAGATCTCAGCCCGATTCTCAGATGGCCTGGAATCCAACAG
CAGCACCCAGTTTGAGGTGAAGAAATATGTCCTTCCCAACTTTGAGGTGAAGATCACCCCTGGAAAGCCCTACATCCTGACGGTGCCAGG
CCATCTTGATGAAATGCAGTTAGACATCCAGGCCAGGTACATCTATGGGAAGCCAGTGCAGGGGGTGGCATATGTGCGCTTTGGGCTCCT
AGATGAGGATGGTAAGAAGACTTTCTTTCGGGGGCTGGAGAGTCAGACCAAGCTGGTGAATGGACAGAGCCACATTTCCCTCTCAAAGGC
AGAGTTCCAGGACGCCCTGGAGAAGCTGAATATGGGCATTACTGACCTCCAGGGGCTGCGCCTCTACGTTGCTGCAGCCATCATTGAGTC
TCCAGGAGTTGTCAAGGCAGCAGAAAGGAGTCACCCAGCCAAAGGAGGAGATGGCTCAGCGGGGCTGCACCAAGGGGCCAAGAGGCCCTA
CCCGTGTCTAAACCCTCCTCTCACTCCCCTAAGCCTGGTGAAAGAGTCAGAAGCCCCAGGCTCCTTTTTCTGTTTCTTAACTCAACAGCT
AAAAAATGGCTCCAGGTAGTGAGTCAATGAAGTTCAGACATGTTGGTGTAAAGTTTCTCCTCTGCTCCTGAAAACTTCATCTTCTTGGTG
TCTCATGTCCTCATTCTCCCCTATATGACATGCAAAAACGATCTTTCTTTGAAATCCCTCTGGGAAGAAGCATGTTTATTGAAACTGTCC
TTCAGCCTTAAATACAAAAATAAAACTGAAACTGCTCCAGAAAGCAGCTTTCTCC

>11762_11762_4_C4A-SAPCD1_C4A_chr6_31952185_ENST00000498271_SAPCD1_chr6_31732213_ENST00000425424_length(amino acids)=417AA_BP=352
MDPPAMRLLWGLIWASSFFTLSLQKPRLLLFSPSVVHLGVPLSVGVQLQDVPRGQVVKGSVFLRNPSRNNVPCSPKVDFTLSSERDFALL
SLQVPLKDAKSCGLHQLLRGPEVQLVAHSPWLKDSLSRTTNIQGINLLFSSRRGHLFLQTDQPIYNPGQRVRYRVFALDQKMRPSTDTIT
VMVENSHGLRVRKKEVYMPSSIFQDDFVIPDISEPGTWKISARFSDGLESNSSTQFEVKKYVLPNFEVKITPGKPYILTVPGHLDEMQLD
IQARYIYGKPVQGVAYVRFGLLDEDGKKTFFRGLESQTKLVNGQSHISLSKAEFQDALEKLNMGITDLQGLRLYVAAAIIESPGVVKAAE
RSHPAKGGDGSAGLHQGAKRPYPCLNPPLTPLSLVKESEAPGSFFCFLTQQLKNGSR

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Fusion Gene PPI Analysis for C4A-SAPCD1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for C4A-SAPCD1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for C4A-SAPCD1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	C4A	C0024141	Lupus Erythematosus, Systemic	6	ORPHANET
Hgene	C4A	C0003257	Antibody Deficiency Syndrome	1	CTD_human
Hgene	C4A	C0004943	Behcet Syndrome	1	ORPHANET
Hgene	C4A	C0021051	Immunologic Deficiency Syndromes	1	CTD_human
Hgene	C4A	C0272242	Complement deficiency disease	1	GENOMICS_ENGLAND
Hgene	C4A	C3280642	Complement Component 4a Deficiency	1	CTD_human;GENOMICS_ENGLAND
Hgene	C4A	C3280742	SYSTEMIC LUPUS ERYTHEMATOSUS 16	1	ORPHANET

Fusion Gene Studies in Kim Lab

Fusion gene:C4A-SAPCD1 (FusionGDB2 ID:HG720TG401251)

Fusion Gene Summary for C4A-SAPCD1

Fusion Gene ORF analysis for C4A-SAPCD1

Fusion Genomic Features for C4A-SAPCD1

Fusion Protein Features for C4A-SAPCD1

Fusion Gene Sequence for C4A-SAPCD1

Fusion Gene PPI Analysis for C4A-SAPCD1

Related Drugs for C4A-SAPCD1

Related Diseases for C4A-SAPCD1

Fusion Gene Studies
in Kim Lab