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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF154-KIR2DL1 (FusionGDB2 ID:HG7710TG3802)

Fusion Gene Summary for ZNF154-KIR2DL1

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF154-KIR2DL1
Fusion gene ID: hg7710tg3802
HgeneTgene
Gene symbol

ZNF154

KIR2DL1

Gene ID

7710

3802

Gene namezinc finger protein 154killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1
SynonymspHZ-92CD158A|KIR-K64|KIR221|KIR2DL3|NKAT|NKAT-1|NKAT1|p58.1
Cytomap('ZNF154')('KIR2DL1')

19q13.43

19q13.42

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 154killer cell immunoglobulin-like receptor 2DL1CD158 antigen-like family member AKIR2DL proteinKIR2DL1/3DL2MHC class I NK cell receptorkiller cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1killer inhibitory receptor 2-2-1natu
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000426889, ENST00000512439, 
Fusion gene scores* DoF score2 X 2 X 1=43 X 4 X 2=24
# samples 14
** MAII scorelog2(1/4*10)=1.32192809488736log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZNF154 [Title/Abstract] AND KIR2DL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF154(58216221)-KIR2DL1(55284785), # samples:2
Anticipated loss of major functional domain due to fusion event.ZNF154-KIR2DL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF154-KIR2DL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF154-KIR2DL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF154-KIR2DL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF154-KIR2DL1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneKIR2DL1

GO:0002769

natural killer cell inhibitory signaling pathway

18604210


check buttonFusion gene breakpoints across ZNF154 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across KIR2DL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A1-A0SQ-01AZNF154chr19

58216221

-KIR2DL1chr19

55282301

+
ChimerDB4BRCATCGA-A1-A0SQ-01AZNF154chr19

58216221

-KIR2DL1chr19

55284785

+
ChimerDB4BRCATCGA-A1-A0SQ-01AZNF154chr19

58220307

-KIR2DL1chr19

55282301

+
ChimerDB4BRCATCGA-A1-A0SQ-01AZNF154chr19

58220307

-KIR2DL1chr19

55284785

+


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Fusion Gene ORF analysis for ZNF154-KIR2DL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000426889ENST00000291633ZNF154chr19

58220307

-KIR2DL1chr19

55282301

+
Frame-shiftENST00000426889ENST00000291633ZNF154chr19

58220307

-KIR2DL1chr19

55284785

+
Frame-shiftENST00000426889ENST00000336077ZNF154chr19

58220307

-KIR2DL1chr19

55282301

+
Frame-shiftENST00000426889ENST00000336077ZNF154chr19

58220307

-KIR2DL1chr19

55284785

+
Frame-shiftENST00000512439ENST00000291633ZNF154chr19

58216221

-KIR2DL1chr19

55282301

+
Frame-shiftENST00000512439ENST00000291633ZNF154chr19

58216221

-KIR2DL1chr19

55284785

+
Frame-shiftENST00000512439ENST00000291633ZNF154chr19

58220307

-KIR2DL1chr19

55282301

+
Frame-shiftENST00000512439ENST00000291633ZNF154chr19

58220307

-KIR2DL1chr19

55284785

+
Frame-shiftENST00000512439ENST00000336077ZNF154chr19

58216221

-KIR2DL1chr19

55282301

+
Frame-shiftENST00000512439ENST00000336077ZNF154chr19

58216221

-KIR2DL1chr19

55284785

+
Frame-shiftENST00000512439ENST00000336077ZNF154chr19

58220307

-KIR2DL1chr19

55282301

+
Frame-shiftENST00000512439ENST00000336077ZNF154chr19

58220307

-KIR2DL1chr19

55284785

+
In-frameENST00000426889ENST00000291633ZNF154chr19

58216221

-KIR2DL1chr19

55282301

+
In-frameENST00000426889ENST00000291633ZNF154chr19

58216221

-KIR2DL1chr19

55284785

+
In-frameENST00000426889ENST00000336077ZNF154chr19

58216221

-KIR2DL1chr19

55282301

+
In-frameENST00000426889ENST00000336077ZNF154chr19

58216221

-KIR2DL1chr19

55284785

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000426889ZNF154chr1958216221-ENST00000336077KIR2DL1chr1955284785+18864001771376399
ENST00000426889ZNF154chr1958216221-ENST00000291633KIR2DL1chr1955284785+15074001771454425
ENST00000426889ZNF154chr1958216221-ENST00000336077KIR2DL1chr1955282301+19224001771412411
ENST00000426889ZNF154chr1958216221-ENST00000291633KIR2DL1chr1955282301+15434001771490437

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000426889ENST00000336077ZNF154chr1958216221-KIR2DL1chr1955284785+0.0208754350.9791246
ENST00000426889ENST00000291633ZNF154chr1958216221-KIR2DL1chr1955284785+0.048833280.95116675
ENST00000426889ENST00000336077ZNF154chr1958216221-KIR2DL1chr1955282301+0.0256003380.9743997
ENST00000426889ENST00000291633ZNF154chr1958216221-KIR2DL1chr1955282301+0.046570530.95342946

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Fusion Genomic Features for ZNF154-KIR2DL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ZNF154chr1958216220-KIR2DL1chr1955282300+0.002977650.99702233
ZNF154chr1958220306-KIR2DL1chr1955282300+0.0001177540.9998822
ZNF154chr1958216220-KIR2DL1chr1955284784+4.65E-050.9999535
ZNF154chr1958220306-KIR2DL1chr1955284784+7.05E-070.9999993
ZNF154chr1958216220-KIR2DL1chr1955282300+0.002977650.99702233
ZNF154chr1958220306-KIR2DL1chr1955282300+0.0001177540.9998822
ZNF154chr1958216220-KIR2DL1chr1955284784+4.65E-050.9999535
ZNF154chr1958220306-KIR2DL1chr1955284784+7.05E-070.9999993

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ZNF154-KIR2DL1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:58216221/chr19:55284785)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKIR2DL1chr19:58216221chr19:55282301ENST0000033607708142_20511349.0DomainNote=Ig-like C2-type 2
TgeneKIR2DL1chr19:58216221chr19:55282301ENST000003360770842_10711349.0DomainNote=Ig-like C2-type 1
TgeneKIR2DL1chr19:58216221chr19:55284785ENST0000033607718142_20523349.0DomainNote=Ig-like C2-type 2
TgeneKIR2DL1chr19:58216221chr19:55284785ENST000003360771842_10723349.0DomainNote=Ig-like C2-type 1
TgeneKIR2DL1chr19:58216221chr19:55282301ENST000003360770822_24511349.0Topological domainExtracellular
TgeneKIR2DL1chr19:58216221chr19:55282301ENST0000033607708265_34811349.0Topological domainCytoplasmic
TgeneKIR2DL1chr19:58216221chr19:55284785ENST000003360771822_24523349.0Topological domainExtracellular
TgeneKIR2DL1chr19:58216221chr19:55284785ENST0000033607718265_34823349.0Topological domainCytoplasmic
TgeneKIR2DL1chr19:58216221chr19:55282301ENST0000033607708246_26411349.0TransmembraneHelical
TgeneKIR2DL1chr19:58216221chr19:55284785ENST0000033607718246_26423349.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF154chr19:58216221chr19:55282301ENST00000426889-2314_8853438.0DomainKRAB
HgeneZNF154chr19:58216221chr19:55282301ENST00000512439-2414_88532095.6666666666665DomainKRAB
HgeneZNF154chr19:58216221chr19:55284785ENST00000426889-2314_8853438.0DomainKRAB
HgeneZNF154chr19:58216221chr19:55284785ENST00000512439-2414_88532095.6666666666665DomainKRAB
HgeneZNF154chr19:58216221chr19:55282301ENST00000426889-23133_15553438.0Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF154chr19:58216221chr19:55282301ENST00000426889-23161_18353438.0Zinc fingerC2H2-type 3
HgeneZNF154chr19:58216221chr19:55282301ENST00000426889-23189_21153438.0Zinc fingerC2H2-type 4
HgeneZNF154chr19:58216221chr19:55282301ENST00000426889-23217_23953438.0Zinc fingerC2H2-type 5
HgeneZNF154chr19:58216221chr19:55282301ENST00000426889-23245_26753438.0Zinc fingerC2H2-type 6
HgeneZNF154chr19:58216221chr19:55282301ENST00000426889-23273_29553438.0Zinc fingerC2H2-type 7
HgeneZNF154chr19:58216221chr19:55282301ENST00000426889-23301_32353438.0Zinc fingerC2H2-type 8
HgeneZNF154chr19:58216221chr19:55282301ENST00000426889-23329_35153438.0Zinc fingerC2H2-type 9
HgeneZNF154chr19:58216221chr19:55282301ENST00000426889-23357_37953438.0Zinc fingerC2H2-type 10
HgeneZNF154chr19:58216221chr19:55282301ENST00000426889-23385_40753438.0Zinc fingerC2H2-type 11
HgeneZNF154chr19:58216221chr19:55282301ENST00000426889-23413_43553438.0Zinc fingerC2H2-type 12
HgeneZNF154chr19:58216221chr19:55282301ENST00000426889-2389_11153438.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF154chr19:58216221chr19:55282301ENST00000512439-24133_155532095.6666666666665Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF154chr19:58216221chr19:55282301ENST00000512439-24161_183532095.6666666666665Zinc fingerC2H2-type 3
HgeneZNF154chr19:58216221chr19:55282301ENST00000512439-24189_211532095.6666666666665Zinc fingerC2H2-type 4
HgeneZNF154chr19:58216221chr19:55282301ENST00000512439-24217_239532095.6666666666665Zinc fingerC2H2-type 5
HgeneZNF154chr19:58216221chr19:55282301ENST00000512439-24245_267532095.6666666666665Zinc fingerC2H2-type 6
HgeneZNF154chr19:58216221chr19:55282301ENST00000512439-24273_295532095.6666666666665Zinc fingerC2H2-type 7
HgeneZNF154chr19:58216221chr19:55282301ENST00000512439-24301_323532095.6666666666665Zinc fingerC2H2-type 8
HgeneZNF154chr19:58216221chr19:55282301ENST00000512439-24329_351532095.6666666666665Zinc fingerC2H2-type 9
HgeneZNF154chr19:58216221chr19:55282301ENST00000512439-24357_379532095.6666666666665Zinc fingerC2H2-type 10
HgeneZNF154chr19:58216221chr19:55282301ENST00000512439-24385_407532095.6666666666665Zinc fingerC2H2-type 11
HgeneZNF154chr19:58216221chr19:55282301ENST00000512439-24413_435532095.6666666666665Zinc fingerC2H2-type 12
HgeneZNF154chr19:58216221chr19:55282301ENST00000512439-2489_111532095.6666666666665Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF154chr19:58216221chr19:55284785ENST00000426889-23133_15553438.0Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF154chr19:58216221chr19:55284785ENST00000426889-23161_18353438.0Zinc fingerC2H2-type 3
HgeneZNF154chr19:58216221chr19:55284785ENST00000426889-23189_21153438.0Zinc fingerC2H2-type 4
HgeneZNF154chr19:58216221chr19:55284785ENST00000426889-23217_23953438.0Zinc fingerC2H2-type 5
HgeneZNF154chr19:58216221chr19:55284785ENST00000426889-23245_26753438.0Zinc fingerC2H2-type 6
HgeneZNF154chr19:58216221chr19:55284785ENST00000426889-23273_29553438.0Zinc fingerC2H2-type 7
HgeneZNF154chr19:58216221chr19:55284785ENST00000426889-23301_32353438.0Zinc fingerC2H2-type 8
HgeneZNF154chr19:58216221chr19:55284785ENST00000426889-23329_35153438.0Zinc fingerC2H2-type 9
HgeneZNF154chr19:58216221chr19:55284785ENST00000426889-23357_37953438.0Zinc fingerC2H2-type 10
HgeneZNF154chr19:58216221chr19:55284785ENST00000426889-23385_40753438.0Zinc fingerC2H2-type 11
HgeneZNF154chr19:58216221chr19:55284785ENST00000426889-23413_43553438.0Zinc fingerC2H2-type 12
HgeneZNF154chr19:58216221chr19:55284785ENST00000426889-2389_11153438.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF154chr19:58216221chr19:55284785ENST00000512439-24133_155532095.6666666666665Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF154chr19:58216221chr19:55284785ENST00000512439-24161_183532095.6666666666665Zinc fingerC2H2-type 3
HgeneZNF154chr19:58216221chr19:55284785ENST00000512439-24189_211532095.6666666666665Zinc fingerC2H2-type 4
HgeneZNF154chr19:58216221chr19:55284785ENST00000512439-24217_239532095.6666666666665Zinc fingerC2H2-type 5
HgeneZNF154chr19:58216221chr19:55284785ENST00000512439-24245_267532095.6666666666665Zinc fingerC2H2-type 6
HgeneZNF154chr19:58216221chr19:55284785ENST00000512439-24273_295532095.6666666666665Zinc fingerC2H2-type 7
HgeneZNF154chr19:58216221chr19:55284785ENST00000512439-24301_323532095.6666666666665Zinc fingerC2H2-type 8
HgeneZNF154chr19:58216221chr19:55284785ENST00000512439-24329_351532095.6666666666665Zinc fingerC2H2-type 9
HgeneZNF154chr19:58216221chr19:55284785ENST00000512439-24357_379532095.6666666666665Zinc fingerC2H2-type 10
HgeneZNF154chr19:58216221chr19:55284785ENST00000512439-24385_407532095.6666666666665Zinc fingerC2H2-type 11
HgeneZNF154chr19:58216221chr19:55284785ENST00000512439-24413_435532095.6666666666665Zinc fingerC2H2-type 12
HgeneZNF154chr19:58216221chr19:55284785ENST00000512439-2489_111532095.6666666666665Zinc fingerC2H2-type 1%3B degenerate


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Fusion Gene Sequence for ZNF154-KIR2DL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>101543_101543_1_ZNF154-KIR2DL1_ZNF154_chr19_58216221_ENST00000426889_KIR2DL1_chr19_55282301_ENST00000291633_length(transcript)=1543nt_BP=400nt
CCTCTTCGTGGCGGCCATTTTAGCTTCTCTGAGGTGTGTTCACCGGATCAGAGATAGCAGAGCGCCGAGTTGGGGCCACGAAGGCGTGAG
GGGAGTCGTCGTCCCTCCTGCACGAAAGCGTCTAAGCCTTGGCGACGCCGCCCTGGGGGACCCACGTCAGGCCTGGGATAGGGACCGCTG
TCCCCGGGTCCCTACCAATGTCGCCCGTCGCTCCCGGCCCAGCTCTACCCGCAGAGTCTGATGGCAGCGGCCACTCTGAGGACGCCAACT
CAGGGCACTGTGACCTTTGAAGATGTGGCCGTACACTTCTCCTGGGAGGAATGGGGTCTCCTTGATGAGGCTCAAAGATGCCTGTACCGT
GATGTGATGCTGGAGAACTTGGCTCTTTTAACCTCTCTAGGGTTCTTCTTGCTGCAGGGGGCCTGGCCACATGAGGGAGTCCACAGAAAA
CCTTCCCTCCTGGCCCACCCAGGTCGCCTGGTGAAATCAGAAGAGACAGTCATCCTGCAGTGTTGGTCAGATGTCATGTTTGAACACTTC
CTTCTGCACAGAGAGGGGATGTTTAACGACACTTTGCGCCTCATTGGAGAACACCATGATGGGGTCTCCAAGGCCAACTTCTCCATCAGT
CGCATGACGCAAGACCTGGCAGGGACCTACAGATGCTACGGTTCTGTTACTCACTCCCCCTATCAGGTGTCAGCTCCCAGTGACCCTCTG
GACATCGTGATCATAGGTCTATATGAGAAACCTTCTCTCTCAGCCCAGCTGGGCCCCACGGTTCTGGCAGGAGAGAATGTGACCTTGTCC
TGCAGCTCCCGGAGCTCCTATGACATGTACCATCTATCCAGGGAAGGGGAGGCCCATGAACGTAGGCTCCCTGCAGGGCCCAAGGTCAAC
GGAACATTCCAGGCTGACTTTCCTCTGGGCCCTGCCACCCACGGAGGGACCTACAGATGCTTCGGCTCTTTCCATGACTCTCCATACGAG
TGGTCAAAGTCAAGTGACCCACTGCTTGTTTCTGTCACAGGAAACCCTTCAAATAGTTGGCCTTCACCCACTGAACCAAGCTCCAAAACC
GAGAGGATGTTTCACCACGTTGGCCAAGCTTGTCTGAAACTCCCAACCTCAAGTGATCCGACCGTCTCAGCATGCCAAAGTAACCCCCGA
CACCTGCACATTCTGATTGGGACCTCAGTGGTCATCATCCTCTTCATCCTCCTCTTCTTTCTCCTTCATCGCTGGTGCTCCAACAAAAAA
AATGCTGCGGTAATGGACCAAGAGTCTGCAGGAAACAGAACAGCGAATAGCGAGGACTCTGATGAACAAGACCCTCAGGAGGTGACATAC
ACACAGTTGAATCACTGCGTTTTCACACAGAGAAAAATCACTCGCCCTTCTCAGAGGCCCAAGACACCCCCAACAGATATCATCGTGTAC
ACGGAACTTCCAAATGCTGAGTCCAGATCCAAAGTTGTCTCCTGCCCATGAGCACCACAGTCAGGCCTTGAGGGCGTCTTCTAGGGAGAC
AACAGCCCTGTCT

>101543_101543_1_ZNF154-KIR2DL1_ZNF154_chr19_58216221_ENST00000426889_KIR2DL1_chr19_55282301_ENST00000291633_length(amino acids)=437AA_BP=158
MSPGPYQCRPSLPAQLYPQSLMAAATLRTPTQGTVTFEDVAVHFSWEEWGLLDEAQRCLYRDVMLENLALLTSLGFFLLQGAWPHEGVHR
KPSLLAHPGRLVKSEETVILQCWSDVMFEHFLLHREGMFNDTLRLIGEHHDGVSKANFSISRMTQDLAGTYRCYGSVTHSPYQVSAPSDP
LDIVIIGLYEKPSLSAQLGPTVLAGENVTLSCSSRSSYDMYHLSREGEAHERRLPAGPKVNGTFQADFPLGPATHGGTYRCFGSFHDSPY
EWSKSSDPLLVSVTGNPSNSWPSPTEPSSKTERMFHHVGQACLKLPTSSDPTVSACQSNPRHLHILIGTSVVIILFILLFFLLHRWCSNK
KNAAVMDQESAGNRTANSEDSDEQDPQEVTYTQLNHCVFTQRKITRPSQRPKTPPTDIIVYTELPNAESRSKVVSCP

--------------------------------------------------------------
>101543_101543_2_ZNF154-KIR2DL1_ZNF154_chr19_58216221_ENST00000426889_KIR2DL1_chr19_55282301_ENST00000336077_length(transcript)=1922nt_BP=400nt
CCTCTTCGTGGCGGCCATTTTAGCTTCTCTGAGGTGTGTTCACCGGATCAGAGATAGCAGAGCGCCGAGTTGGGGCCACGAAGGCGTGAG
GGGAGTCGTCGTCCCTCCTGCACGAAAGCGTCTAAGCCTTGGCGACGCCGCCCTGGGGGACCCACGTCAGGCCTGGGATAGGGACCGCTG
TCCCCGGGTCCCTACCAATGTCGCCCGTCGCTCCCGGCCCAGCTCTACCCGCAGAGTCTGATGGCAGCGGCCACTCTGAGGACGCCAACT
CAGGGCACTGTGACCTTTGAAGATGTGGCCGTACACTTCTCCTGGGAGGAATGGGGTCTCCTTGATGAGGCTCAAAGATGCCTGTACCGT
GATGTGATGCTGGAGAACTTGGCTCTTTTAACCTCTCTAGGGTTCTTCTTGCTGCAGGGGGCCTGGCCACATGAGGGAGTCCACAGAAAA
CCTTCCCTCCTGGCCCACCCAGGTCGCCTGGTGAAATCAGAAGAGACAGTCATCCTGCAGTGTTGGTCAGATGTCATGTTTGAACACTTC
CTTCTGCACAGAGAGGGGATGTTTAACGACACTTTGCGCCTCATTGGAGAACACCATGATGGGGTCTCCAAGGCCAACTTCTCCATCAGT
CGCATGACGCAAGACCTGGCAGGGACCTACAGATGCTACGGTTCTGTTACTCACTCCCCCTATCAGGTGTCAGCTCCCAGTGACCCTCTG
GACATCGTGATCATAGGTCTATATGAGAAACCTTCTCTCTCAGCCCAGCTGGGCCCCACGGTTCTGGCAGGAGAGAATGTGACCTTGTCC
TGCAGCTCCCGGAGCTCCTATGACATGTACCATCTATCCAGGGAAGGGGAGGCCCATGAACGTAGGCTCCCTGCAGGGCCCAAGGTCAAC
GGAACATTCCAGGCTGACTTTCCTCTGGGCCCTGCCACCCACGGAGGGACCTACAGATGCTTCGGCTCTTTCCATGACTCTCCATACGAG
TGGTCAAAGTCAAGTGACCCACTGCTTGTTTCTGTCACAGGAAACCCTTCAAATAGTTGGCCTTCACCCACTGAACCAAGCTCCAAAACC
GGTAACCCCCGACACCTGCACATTCTGATTGGGACCTCAGTGGTCATCATCCTCTTCATCCTCCTCTTCTTTCTCCTTCATCGCTGGTGC
TCCAACAAAAAAAATGCTGCGGTAATGGACCAAGAGTCTGCAGGAAACAGAACAGCGAATAGCGAGGACTCTGATGAACAAGACCCTCAG
GAGGTGACATACACACAGTTGAATCACTGCGTTTTCACACAGAGAAAAATCACTCGCCCTTCTCAGAGGCCCAAGACACCCCCAACAGAT
ATCATCGTGTACACGGAACTTCCAAATGCTGAGTCCAGATCCAAAGTTGTCTCCTGCCCATGAGCACCACAGTCAGGCCTTGAGGGCGTC
TTCTAGGGAGACAACAGCCCTGTCTCAAAACCGGGTTGCCAGCTCCCATGTACCAGCAGCTGGAATCTGAAGGCGTGAGTCTGCATCTTA
GGGCATCGATCTTCCTCACACCACAAATCTGAATGTGCCTCTCTCTTGCTTACAAATGTCTAAGGTCCCCACTGCCTGCTGGAGAAAAAA
CACACTCCTTTGCTTAACCCACAGTTCTCCATTTCACTTGACCCCTGCCCACCTCTCCAACCTAACTGGCTTACTTCCTAGTCTACTTGA
GGCTGCAATCACACTGAGGAACTCACAATTCCAAACATACAAGAGGCTCCCTCTTAACGCAGCACTTAGACACGTGTTGTTCCACCTTCC
CTCATGCTGTTCCACCTCCCCTCAGACTAGCTTTCAGTCTTCTGTCAGCAGTAAAACTTATATATTTTTTAAAATAACTTCAATGTAGTT
TTCCATCCTTCAAATAAACATGTCTGCCCCCA

>101543_101543_2_ZNF154-KIR2DL1_ZNF154_chr19_58216221_ENST00000426889_KIR2DL1_chr19_55282301_ENST00000336077_length(amino acids)=411AA_BP=145
MSPGPYQCRPSLPAQLYPQSLMAAATLRTPTQGTVTFEDVAVHFSWEEWGLLDEAQRCLYRDVMLENLALLTSLGFFLLQGAWPHEGVHR
KPSLLAHPGRLVKSEETVILQCWSDVMFEHFLLHREGMFNDTLRLIGEHHDGVSKANFSISRMTQDLAGTYRCYGSVTHSPYQVSAPSDP
LDIVIIGLYEKPSLSAQLGPTVLAGENVTLSCSSRSSYDMYHLSREGEAHERRLPAGPKVNGTFQADFPLGPATHGGTYRCFGSFHDSPY
EWSKSSDPLLVSVTGNPSNSWPSPTEPSSKTGNPRHLHILIGTSVVIILFILLFFLLHRWCSNKKNAAVMDQESAGNRTANSEDSDEQDP
QEVTYTQLNHCVFTQRKITRPSQRPKTPPTDIIVYTELPNAESRSKVVSCP

--------------------------------------------------------------
>101543_101543_3_ZNF154-KIR2DL1_ZNF154_chr19_58216221_ENST00000426889_KIR2DL1_chr19_55284785_ENST00000291633_length(transcript)=1507nt_BP=400nt
CCTCTTCGTGGCGGCCATTTTAGCTTCTCTGAGGTGTGTTCACCGGATCAGAGATAGCAGAGCGCCGAGTTGGGGCCACGAAGGCGTGAG
GGGAGTCGTCGTCCCTCCTGCACGAAAGCGTCTAAGCCTTGGCGACGCCGCCCTGGGGGACCCACGTCAGGCCTGGGATAGGGACCGCTG
TCCCCGGGTCCCTACCAATGTCGCCCGTCGCTCCCGGCCCAGCTCTACCCGCAGAGTCTGATGGCAGCGGCCACTCTGAGGACGCCAACT
CAGGGCACTGTGACCTTTGAAGATGTGGCCGTACACTTCTCCTGGGAGGAATGGGGTCTCCTTGATGAGGCTCAAAGATGCCTGTACCGT
GATGTGATGCTGGAGAACTTGGCTCTTTTAACCTCTCTAGGAGTCCACAGAAAACCTTCCCTCCTGGCCCACCCAGGTCGCCTGGTGAAA
TCAGAAGAGACAGTCATCCTGCAGTGTTGGTCAGATGTCATGTTTGAACACTTCCTTCTGCACAGAGAGGGGATGTTTAACGACACTTTG
CGCCTCATTGGAGAACACCATGATGGGGTCTCCAAGGCCAACTTCTCCATCAGTCGCATGACGCAAGACCTGGCAGGGACCTACAGATGC
TACGGTTCTGTTACTCACTCCCCCTATCAGGTGTCAGCTCCCAGTGACCCTCTGGACATCGTGATCATAGGTCTATATGAGAAACCTTCT
CTCTCAGCCCAGCTGGGCCCCACGGTTCTGGCAGGAGAGAATGTGACCTTGTCCTGCAGCTCCCGGAGCTCCTATGACATGTACCATCTA
TCCAGGGAAGGGGAGGCCCATGAACGTAGGCTCCCTGCAGGGCCCAAGGTCAACGGAACATTCCAGGCTGACTTTCCTCTGGGCCCTGCC
ACCCACGGAGGGACCTACAGATGCTTCGGCTCTTTCCATGACTCTCCATACGAGTGGTCAAAGTCAAGTGACCCACTGCTTGTTTCTGTC
ACAGGAAACCCTTCAAATAGTTGGCCTTCACCCACTGAACCAAGCTCCAAAACCGAGAGGATGTTTCACCACGTTGGCCAAGCTTGTCTG
AAACTCCCAACCTCAAGTGATCCGACCGTCTCAGCATGCCAAAGTAACCCCCGACACCTGCACATTCTGATTGGGACCTCAGTGGTCATC
ATCCTCTTCATCCTCCTCTTCTTTCTCCTTCATCGCTGGTGCTCCAACAAAAAAAATGCTGCGGTAATGGACCAAGAGTCTGCAGGAAAC
AGAACAGCGAATAGCGAGGACTCTGATGAACAAGACCCTCAGGAGGTGACATACACACAGTTGAATCACTGCGTTTTCACACAGAGAAAA
ATCACTCGCCCTTCTCAGAGGCCCAAGACACCCCCAACAGATATCATCGTGTACACGGAACTTCCAAATGCTGAGTCCAGATCCAAAGTT
GTCTCCTGCCCATGAGCACCACAGTCAGGCCTTGAGGGCGTCTTCTAGGGAGACAACAGCCCTGTCT

>101543_101543_3_ZNF154-KIR2DL1_ZNF154_chr19_58216221_ENST00000426889_KIR2DL1_chr19_55284785_ENST00000291633_length(amino acids)=425AA_BP=31
MSPGPYQCRPSLPAQLYPQSLMAAATLRTPTQGTVTFEDVAVHFSWEEWGLLDEAQRCLYRDVMLENLALLTSLGVHRKPSLLAHPGRLV
KSEETVILQCWSDVMFEHFLLHREGMFNDTLRLIGEHHDGVSKANFSISRMTQDLAGTYRCYGSVTHSPYQVSAPSDPLDIVIIGLYEKP
SLSAQLGPTVLAGENVTLSCSSRSSYDMYHLSREGEAHERRLPAGPKVNGTFQADFPLGPATHGGTYRCFGSFHDSPYEWSKSSDPLLVS
VTGNPSNSWPSPTEPSSKTERMFHHVGQACLKLPTSSDPTVSACQSNPRHLHILIGTSVVIILFILLFFLLHRWCSNKKNAAVMDQESAG
NRTANSEDSDEQDPQEVTYTQLNHCVFTQRKITRPSQRPKTPPTDIIVYTELPNAESRSKVVSCP

--------------------------------------------------------------
>101543_101543_4_ZNF154-KIR2DL1_ZNF154_chr19_58216221_ENST00000426889_KIR2DL1_chr19_55284785_ENST00000336077_length(transcript)=1886nt_BP=400nt
CCTCTTCGTGGCGGCCATTTTAGCTTCTCTGAGGTGTGTTCACCGGATCAGAGATAGCAGAGCGCCGAGTTGGGGCCACGAAGGCGTGAG
GGGAGTCGTCGTCCCTCCTGCACGAAAGCGTCTAAGCCTTGGCGACGCCGCCCTGGGGGACCCACGTCAGGCCTGGGATAGGGACCGCTG
TCCCCGGGTCCCTACCAATGTCGCCCGTCGCTCCCGGCCCAGCTCTACCCGCAGAGTCTGATGGCAGCGGCCACTCTGAGGACGCCAACT
CAGGGCACTGTGACCTTTGAAGATGTGGCCGTACACTTCTCCTGGGAGGAATGGGGTCTCCTTGATGAGGCTCAAAGATGCCTGTACCGT
GATGTGATGCTGGAGAACTTGGCTCTTTTAACCTCTCTAGGAGTCCACAGAAAACCTTCCCTCCTGGCCCACCCAGGTCGCCTGGTGAAA
TCAGAAGAGACAGTCATCCTGCAGTGTTGGTCAGATGTCATGTTTGAACACTTCCTTCTGCACAGAGAGGGGATGTTTAACGACACTTTG
CGCCTCATTGGAGAACACCATGATGGGGTCTCCAAGGCCAACTTCTCCATCAGTCGCATGACGCAAGACCTGGCAGGGACCTACAGATGC
TACGGTTCTGTTACTCACTCCCCCTATCAGGTGTCAGCTCCCAGTGACCCTCTGGACATCGTGATCATAGGTCTATATGAGAAACCTTCT
CTCTCAGCCCAGCTGGGCCCCACGGTTCTGGCAGGAGAGAATGTGACCTTGTCCTGCAGCTCCCGGAGCTCCTATGACATGTACCATCTA
TCCAGGGAAGGGGAGGCCCATGAACGTAGGCTCCCTGCAGGGCCCAAGGTCAACGGAACATTCCAGGCTGACTTTCCTCTGGGCCCTGCC
ACCCACGGAGGGACCTACAGATGCTTCGGCTCTTTCCATGACTCTCCATACGAGTGGTCAAAGTCAAGTGACCCACTGCTTGTTTCTGTC
ACAGGAAACCCTTCAAATAGTTGGCCTTCACCCACTGAACCAAGCTCCAAAACCGGTAACCCCCGACACCTGCACATTCTGATTGGGACC
TCAGTGGTCATCATCCTCTTCATCCTCCTCTTCTTTCTCCTTCATCGCTGGTGCTCCAACAAAAAAAATGCTGCGGTAATGGACCAAGAG
TCTGCAGGAAACAGAACAGCGAATAGCGAGGACTCTGATGAACAAGACCCTCAGGAGGTGACATACACACAGTTGAATCACTGCGTTTTC
ACACAGAGAAAAATCACTCGCCCTTCTCAGAGGCCCAAGACACCCCCAACAGATATCATCGTGTACACGGAACTTCCAAATGCTGAGTCC
AGATCCAAAGTTGTCTCCTGCCCATGAGCACCACAGTCAGGCCTTGAGGGCGTCTTCTAGGGAGACAACAGCCCTGTCTCAAAACCGGGT
TGCCAGCTCCCATGTACCAGCAGCTGGAATCTGAAGGCGTGAGTCTGCATCTTAGGGCATCGATCTTCCTCACACCACAAATCTGAATGT
GCCTCTCTCTTGCTTACAAATGTCTAAGGTCCCCACTGCCTGCTGGAGAAAAAACACACTCCTTTGCTTAACCCACAGTTCTCCATTTCA
CTTGACCCCTGCCCACCTCTCCAACCTAACTGGCTTACTTCCTAGTCTACTTGAGGCTGCAATCACACTGAGGAACTCACAATTCCAAAC
ATACAAGAGGCTCCCTCTTAACGCAGCACTTAGACACGTGTTGTTCCACCTTCCCTCATGCTGTTCCACCTCCCCTCAGACTAGCTTTCA
GTCTTCTGTCAGCAGTAAAACTTATATATTTTTTAAAATAACTTCAATGTAGTTTTCCATCCTTCAAATAAACATGTCTGCCCCCA

>101543_101543_4_ZNF154-KIR2DL1_ZNF154_chr19_58216221_ENST00000426889_KIR2DL1_chr19_55284785_ENST00000336077_length(amino acids)=399AA_BP=31
MSPGPYQCRPSLPAQLYPQSLMAAATLRTPTQGTVTFEDVAVHFSWEEWGLLDEAQRCLYRDVMLENLALLTSLGVHRKPSLLAHPGRLV
KSEETVILQCWSDVMFEHFLLHREGMFNDTLRLIGEHHDGVSKANFSISRMTQDLAGTYRCYGSVTHSPYQVSAPSDPLDIVIIGLYEKP
SLSAQLGPTVLAGENVTLSCSSRSSYDMYHLSREGEAHERRLPAGPKVNGTFQADFPLGPATHGGTYRCFGSFHDSPYEWSKSSDPLLVS
VTGNPSNSWPSPTEPSSKTGNPRHLHILIGTSVVIILFILLFFLLHRWCSNKKNAAVMDQESAGNRTANSEDSDEQDPQEVTYTQLNHCV
FTQRKITRPSQRPKTPPTDIIVYTELPNAESRSKVVSCP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZNF154-KIR2DL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF154-KIR2DL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF154-KIR2DL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource