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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Diseases

Fusion gene:AHNAK-RPS6KA4 (FusionGDB2 ID:HG79026TG8986)

Fusion Gene Summary for AHNAK-RPS6KA4

check button Fusion gene summary
Fusion gene informationFusion gene name: AHNAK-RPS6KA4
Fusion gene ID: hg79026tg8986
HgeneTgene
Gene symbol

AHNAK

RPS6KA4

Gene ID

79026

8986

Gene nameAHNAK nucleoproteinribosomal protein S6 kinase A4
SynonymsAHNAKRS|PM227MSK2|RSK-B|S6K-alpha-4
Cytomap('AHNAK')('RPS6KA4')

11q12.3

11q13.1

Type of geneprotein-codingprotein-coding
Descriptionneuroblast differentiation-associated protein AHNAKAHNAK-relateddesmoyokinribosomal protein S6 kinase alpha-490 kDa ribosomal protein S6 kinase 4mitogen- and stress-activated protein kinase 2nuclear mitogen- and stress-activated protein kinase 2ribosomal protein S6 kinase, 90kDa, polypeptide 4ribosomal protein kinase B
Modification date2020032720200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000525875, ENST00000257247, 
ENST00000378024, ENST00000530124, 
Fusion gene scores* DoF score27 X 21 X 12=68042 X 2 X 2=8
# samples 343
** MAII scorelog2(34/6804*10)=-4.32277648952568
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/8*10)=1.90689059560852
Context

PubMed: AHNAK [Title/Abstract] AND RPS6KA4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAHNAK(62259204)-RPS6KA4(64132773), # samples:3
Anticipated loss of major functional domain due to fusion event.AHNAK-RPS6KA4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AHNAK-RPS6KA4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AHNAK-RPS6KA4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AHNAK-RPS6KA4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRPS6KA4

GO:0006355

regulation of transcription, DNA-templated

9792677

TgeneRPS6KA4

GO:0006468

protein phosphorylation

9792677

TgeneRPS6KA4

GO:0035556

intracellular signal transduction

9792677


check buttonFusion gene breakpoints across AHNAK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across RPS6KA4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A09E-01AAHNAKchr11

62259204

-RPS6KA4chr11

64132773

+
ChimerDB4BRCATCGA-A8-A09EAHNAKchr11

62259203

-RPS6KA4chr11

64132772

+


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Fusion Gene ORF analysis for AHNAK-RPS6KA4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000525875ENST00000294261AHNAKchr11

62259204

-RPS6KA4chr11

64132773

+
5UTR-3CDSENST00000525875ENST00000294261AHNAKchr11

62259203

-RPS6KA4chr11

64132772

+
5UTR-3CDSENST00000525875ENST00000334205AHNAKchr11

62259204

-RPS6KA4chr11

64132773

+
5UTR-3CDSENST00000525875ENST00000334205AHNAKchr11

62259203

-RPS6KA4chr11

64132772

+
5UTR-3CDSENST00000525875ENST00000528057AHNAKchr11

62259204

-RPS6KA4chr11

64132773

+
5UTR-3CDSENST00000525875ENST00000528057AHNAKchr11

62259203

-RPS6KA4chr11

64132772

+
In-frameENST00000257247ENST00000294261AHNAKchr11

62259204

-RPS6KA4chr11

64132773

+
In-frameENST00000257247ENST00000294261AHNAKchr11

62259203

-RPS6KA4chr11

64132772

+
In-frameENST00000257247ENST00000334205AHNAKchr11

62259204

-RPS6KA4chr11

64132773

+
In-frameENST00000257247ENST00000334205AHNAKchr11

62259203

-RPS6KA4chr11

64132772

+
In-frameENST00000257247ENST00000528057AHNAKchr11

62259204

-RPS6KA4chr11

64132773

+
In-frameENST00000257247ENST00000528057AHNAKchr11

62259203

-RPS6KA4chr11

64132772

+
intron-3CDSENST00000378024ENST00000294261AHNAKchr11

62259204

-RPS6KA4chr11

64132773

+
intron-3CDSENST00000378024ENST00000294261AHNAKchr11

62259203

-RPS6KA4chr11

64132772

+
intron-3CDSENST00000378024ENST00000334205AHNAKchr11

62259204

-RPS6KA4chr11

64132773

+
intron-3CDSENST00000378024ENST00000334205AHNAKchr11

62259203

-RPS6KA4chr11

64132772

+
intron-3CDSENST00000378024ENST00000528057AHNAKchr11

62259204

-RPS6KA4chr11

64132773

+
intron-3CDSENST00000378024ENST00000528057AHNAKchr11

62259203

-RPS6KA4chr11

64132772

+
intron-3CDSENST00000530124ENST00000294261AHNAKchr11

62259204

-RPS6KA4chr11

64132773

+
intron-3CDSENST00000530124ENST00000294261AHNAKchr11

62259203

-RPS6KA4chr11

64132772

+
intron-3CDSENST00000530124ENST00000334205AHNAKchr11

62259204

-RPS6KA4chr11

64132773

+
intron-3CDSENST00000530124ENST00000334205AHNAKchr11

62259203

-RPS6KA4chr11

64132772

+
intron-3CDSENST00000530124ENST00000528057AHNAKchr11

62259204

-RPS6KA4chr11

64132773

+
intron-3CDSENST00000530124ENST00000528057AHNAKchr11

62259203

-RPS6KA4chr11

64132772

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000257247AHNAKchr1162259204-ENST00000528057RPS6KA4chr1164132773+28056786722069465
ENST00000257247AHNAKchr1162259204-ENST00000334205RPS6KA4chr1164132773+28266786722090472
ENST00000257247AHNAKchr1162259204-ENST00000294261RPS6KA4chr1164132773+20816786721346224
ENST00000257247AHNAKchr1162259203-ENST00000528057RPS6KA4chr1164132772+28056786722069465
ENST00000257247AHNAKchr1162259203-ENST00000334205RPS6KA4chr1164132772+28266786722090472
ENST00000257247AHNAKchr1162259203-ENST00000294261RPS6KA4chr1164132772+20816786721346224

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000257247ENST00000528057AHNAKchr1162259204-RPS6KA4chr1164132773+0.08380960.9161904
ENST00000257247ENST00000334205AHNAKchr1162259204-RPS6KA4chr1164132773+0.1068567260.8931433
ENST00000257247ENST00000294261AHNAKchr1162259204-RPS6KA4chr1164132773+0.3615120.638488
ENST00000257247ENST00000528057AHNAKchr1162259203-RPS6KA4chr1164132772+0.08380960.9161904
ENST00000257247ENST00000334205AHNAKchr1162259203-RPS6KA4chr1164132772+0.1068567260.8931433
ENST00000257247ENST00000294261AHNAKchr1162259203-RPS6KA4chr1164132772+0.3615120.638488

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Fusion Genomic Features for AHNAK-RPS6KA4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
AHNAKchr1162259203-RPS6KA4chr1164132772+1.42E-091
AHNAKchr1162259203-RPS6KA4chr1164132772+1.42E-091
AHNAKchr1162259203-RPS6KA4chr1164132772+1.42E-091
AHNAKchr1162259203-RPS6KA4chr1164132772+1.42E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for AHNAK-RPS6KA4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:62259204/chr11:64132773)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAHNAKchr11:62259203chr11:64132772ENST00000257247-569_90147150.0DomainPDZ
HgeneAHNAKchr11:62259204chr11:64132773ENST00000257247-569_90147150.0DomainPDZ
TgeneRPS6KA4chr11:62259203chr11:64132772ENST00000334205717302_371302773.0DomainAGC-kinase C-terminal
TgeneRPS6KA4chr11:62259203chr11:64132772ENST00000334205717411_674302773.0DomainProtein kinase 2
TgeneRPS6KA4chr11:62259204chr11:64132773ENST00000334205717302_371302773.0DomainAGC-kinase C-terminal
TgeneRPS6KA4chr11:62259204chr11:64132773ENST00000334205717411_674302773.0DomainProtein kinase 2
TgeneRPS6KA4chr11:62259203chr11:64132772ENST00000334205717417_425302773.0Nucleotide bindingATP
TgeneRPS6KA4chr11:62259204chr11:64132773ENST00000334205717417_425302773.0Nucleotide bindingATP
TgeneRPS6KA4chr11:62259203chr11:64132772ENST00000334205717725_772302773.0RegionNote=Required for nuclear targeting and association with MAPK14
TgeneRPS6KA4chr11:62259204chr11:64132773ENST00000334205717725_772302773.0RegionNote=Required for nuclear targeting and association with MAPK14

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAHNAKchr11:62259203chr11:64132772ENST00000257247-565458_5654147150.0Compositional biasNote=Gly-rich
HgeneAHNAKchr11:62259203chr11:64132772ENST00000378024-155458_565405891.0Compositional biasNote=Gly-rich
HgeneAHNAKchr11:62259204chr11:64132773ENST00000257247-565458_5654147150.0Compositional biasNote=Gly-rich
HgeneAHNAKchr11:62259204chr11:64132773ENST00000378024-155458_565405891.0Compositional biasNote=Gly-rich
HgeneAHNAKchr11:62259203chr11:64132772ENST00000378024-159_9005891.0DomainPDZ
HgeneAHNAKchr11:62259204chr11:64132773ENST00000378024-159_9005891.0DomainPDZ
HgeneAHNAKchr11:62259203chr11:64132772ENST00000257247-564971_4979147150.0MotifNuclear localization signal
HgeneAHNAKchr11:62259203chr11:64132772ENST00000257247-565019_5027147150.0MotifNuclear localization signal
HgeneAHNAKchr11:62259203chr11:64132772ENST00000257247-565034_5039147150.0MotifNuclear localization signal
HgeneAHNAKchr11:62259203chr11:64132772ENST00000257247-565706_5716147150.0MotifNuclear localization signal
HgeneAHNAKchr11:62259203chr11:64132772ENST00000257247-565772_5779147150.0MotifNuclear localization signal
HgeneAHNAKchr11:62259203chr11:64132772ENST00000378024-154971_497905891.0MotifNuclear localization signal
HgeneAHNAKchr11:62259203chr11:64132772ENST00000378024-155019_502705891.0MotifNuclear localization signal
HgeneAHNAKchr11:62259203chr11:64132772ENST00000378024-155034_503905891.0MotifNuclear localization signal
HgeneAHNAKchr11:62259203chr11:64132772ENST00000378024-155706_571605891.0MotifNuclear localization signal
HgeneAHNAKchr11:62259203chr11:64132772ENST00000378024-155772_577905891.0MotifNuclear localization signal
HgeneAHNAKchr11:62259204chr11:64132773ENST00000257247-564971_4979147150.0MotifNuclear localization signal
HgeneAHNAKchr11:62259204chr11:64132773ENST00000257247-565019_5027147150.0MotifNuclear localization signal
HgeneAHNAKchr11:62259204chr11:64132773ENST00000257247-565034_5039147150.0MotifNuclear localization signal
HgeneAHNAKchr11:62259204chr11:64132773ENST00000257247-565706_5716147150.0MotifNuclear localization signal
HgeneAHNAKchr11:62259204chr11:64132773ENST00000257247-565772_5779147150.0MotifNuclear localization signal
HgeneAHNAKchr11:62259204chr11:64132773ENST00000378024-154971_497905891.0MotifNuclear localization signal
HgeneAHNAKchr11:62259204chr11:64132773ENST00000378024-155019_502705891.0MotifNuclear localization signal
HgeneAHNAKchr11:62259204chr11:64132773ENST00000378024-155034_503905891.0MotifNuclear localization signal
HgeneAHNAKchr11:62259204chr11:64132773ENST00000378024-155706_571605891.0MotifNuclear localization signal
HgeneAHNAKchr11:62259204chr11:64132773ENST00000378024-155772_577905891.0MotifNuclear localization signal
TgeneRPS6KA4chr11:62259203chr11:64132772ENST0000033420571733_301302773.0DomainProtein kinase 1
TgeneRPS6KA4chr11:62259204chr11:64132773ENST0000033420571733_301302773.0DomainProtein kinase 1
TgeneRPS6KA4chr11:62259203chr11:64132772ENST0000033420571739_47302773.0Nucleotide bindingATP
TgeneRPS6KA4chr11:62259204chr11:64132773ENST0000033420571739_47302773.0Nucleotide bindingATP


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Fusion Gene Sequence for AHNAK-RPS6KA4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>3122_3122_1_AHNAK-RPS6KA4_AHNAK_chr11_62259203_ENST00000257247_RPS6KA4_chr11_64132772_ENST00000294261_length(transcript)=2081nt_BP=678nt
AGCTGCTCTGCCGCGGGGACTGCACCGCCCGCCCTGCCAGACCCGCCCGGAACGGGGCTCGTCGCCGCCAGTAGCCGCAGCACCGCAGCC
TTGGGCCTCGCGCCGGCTATGGCCGTGCCCTGGGGCTGAGCCCTCAGGTTGTGACCGAGATTCCCGACGAGAGAGACTGAGGGGAAGAGA
GGAAGGAGGGGCGGGCTCCTGGCAAGGCATTCGCTCCTGAGCGGAATCCTGCAAAGATGGAGAAGGAGGAGACAACCCGGGAGCTGCTGC
TGCCCAACTGGCAGGGTAGTGGCTCCCACGGGCTGACCATCGCCCAGAGGGACGACGGCGTCTTTGTGCAGGAGGTGACGCAGAACTCCC
CTGCGGCCCGCACTGGGGTGGTCAAGGAGGGGGACCAGATTGTGGGTGCCACCATCTACTTTGACAACCTGCAGTCGGGTGAGGTGACCC
AGCTGCTGAACACCATGGGGCACCACACGGTGGGCCTGAAGCTGCACCGCAAGGGGGACCGCTCTCCCGAGCCTGGCCAGACCTGGACCC
GTGAAGTCTTCAGCTCCTGCAGCTCTGAAGTGGTTCTGAACACACCACAGCCATCAGCACTGGAATGCAAAGACCAGAACAAACAGAAGG
AAGCCAGCAGCCAAGCCGGGGCAGTTTCAGTCTCCACCCCAAATGCAGGGCCTCGATTGGGTGGCTCTGGCTGCCAGGAAGATTCCAGCC
CCATTCCGGCCCCAAATCCGCTCAGAGCTGGATGTGGGCAACTTTGCGGAGGAATTCACTCGGCTGGAGCCTGTCTACTCACCCCCTGGC
AGCCCCCCACCTGGGGACCCCCGAATCTTTCAGGGATACTCCTTTGTGGCACCCTCCATTCTCTTTGACCACAACAACGCGGCCGAGATC
ATGTGCAAAATCCGCGAGGGGCGCTTCTCCCTTGACGGGGAGGCCTGGCAGGGTGTATCCGAGGAAGCCAAGGAGCTGGTCCGAGGGCTC
CTGACCGTGGACCCCGCCAAGCGGCTGAAGCTCGAGGGACTGCGGGGCAGCTCGTGGCTGCAGGACGGCAGCGCGCGCTCCTCGCCCCCG
CTCCGGACGCCCGACGTGCTCGAGTCCTCTGGGCCCGCAGTGCGCTCGGGTCTCAACGCCACCTTCATGGCATTCAACCGGGGCAAGCGG
GAGGGCTTCTTCCTGAAGAGCGTGGAGAATGCACCCCTGGCCAAGCGGCGGAAGCAGAAGCTGCGGAGCGCCACCGCCTCCCGCCGGGGC
TCCCCTGCACCAGCCAACCCGGGCCGAGCCCCCGTCGCCTCCAAAGGGGCCCCCCGCCGAGCCAACGGCCCCCTGCCCCCCTCCTAATCC
CCACCACTGTGACCCCCTTCCCTCATAGGGGCTGTGACCTGGGAGCCCGGCTCACTCCCGGAGGCCTCTGCCTGCGGCTGACCTGATCCC
CAAGGGACTGTCCTTTCCTCTCCTACCCCACCCCACTCCCAGACAGAGCAGAAGTATTTTTATAAGCAGAGAATTTTTTATGTCTTACCA
GATAGAGTTGCAGGGAAGGGGGGGCCTGCTGGGGAGTGGGGTTTGGGGGGCCCTCTCCCAGGACACTGCCTCTTCTGGGCAGAAGGCCCC
TCCAGGGGGACTGCTCCAACAGGAAAGAGCCCCTCCCCCACTTCTAAGCACTGAGTTAGGAGTGCTAACTCCTAAACTGGGACCCCCTAC
CCTGTTCTCCCCTGAGGCCCCGTTCCTGGGAGGGGCACCCCTCAACTGTCACTTTATGGACTGTCTGTGCAATTACGTCCACCAAAGACC
CGTGTTGGGGGTACTGAAGGAGAGGCCCTGGGGGACCCTCTGAAGCATTTCTGCCTCACTTTATGTCATCTGCTTCTCCCCTGTTGGGGC
TAAGGAAGGAGATAGGTGGCTCCTAAAAGAGGAGGCCATCTTCTCACCCACCCCTTCCTCTTTGGCACAGCTACTCCTGGCTGGGGGTGG
GGCCTTGGGGGTCTGGGCTGGGCATCCATGGTCACTGCCTCAGCCCAGCCAGGCTGTGCCTTTGACTTTAAAATAAAAGTCCACCCAGTG

>3122_3122_1_AHNAK-RPS6KA4_AHNAK_chr11_62259203_ENST00000257247_RPS6KA4_chr11_64132772_ENST00000294261_length(amino acids)=224AA_BP=1
MQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPSILFDHNNAAEIMCKIREGRFSLDGE
AWQGVSEEAKELVRGLLTVDPAKRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAPLA

--------------------------------------------------------------
>3122_3122_2_AHNAK-RPS6KA4_AHNAK_chr11_62259203_ENST00000257247_RPS6KA4_chr11_64132772_ENST00000334205_length(transcript)=2826nt_BP=678nt
AGCTGCTCTGCCGCGGGGACTGCACCGCCCGCCCTGCCAGACCCGCCCGGAACGGGGCTCGTCGCCGCCAGTAGCCGCAGCACCGCAGCC
TTGGGCCTCGCGCCGGCTATGGCCGTGCCCTGGGGCTGAGCCCTCAGGTTGTGACCGAGATTCCCGACGAGAGAGACTGAGGGGAAGAGA
GGAAGGAGGGGCGGGCTCCTGGCAAGGCATTCGCTCCTGAGCGGAATCCTGCAAAGATGGAGAAGGAGGAGACAACCCGGGAGCTGCTGC
TGCCCAACTGGCAGGGTAGTGGCTCCCACGGGCTGACCATCGCCCAGAGGGACGACGGCGTCTTTGTGCAGGAGGTGACGCAGAACTCCC
CTGCGGCCCGCACTGGGGTGGTCAAGGAGGGGGACCAGATTGTGGGTGCCACCATCTACTTTGACAACCTGCAGTCGGGTGAGGTGACCC
AGCTGCTGAACACCATGGGGCACCACACGGTGGGCCTGAAGCTGCACCGCAAGGGGGACCGCTCTCCCGAGCCTGGCCAGACCTGGACCC
GTGAAGTCTTCAGCTCCTGCAGCTCTGAAGTGGTTCTGAACACACCACAGCCATCAGCACTGGAATGCAAAGACCAGAACAAACAGAAGG
AAGCCAGCAGCCAAGCCGGGGCAGTTTCAGTCTCCACCCCAAATGCAGGGCCTCGATTGGGTGGCTCTGGCTGCCAGGAAGATTCCAGCC
CCATTCCGGCCCCAAATCCGCTCAGAGCTGGATGTGGGCAACTTTGCGGAGGAATTCACTCGGCTGGAGCCTGTCTACTCACCCCCTGGC
AGCCCCCCACCTGGGGACCCCCGAATCTTTCAGGGATACTCCTTTGTGGCACCCTCCATTCTCTTTGACCACAACAACGCGGTGATGACC
GATGGGCTGGAAGCGCCTGGTGCTGGAGACCGGCCAGGTCGGGCAGCGGTGGCCAGGAGCGCTATGATGCAGGACTCGCCCTTCTTCCAG
CAGTACGAGCTGGACCTGCGGGAGCCTGCGCTGGGCCAGGGCAGCTTTTCTGTGTGTCGCCGCTGCCGCCAGCGCCAGAGCGGCCAGGAG
TTCGCAGTCAAGATCCTCAGTCGCAGGCTGGAGGCGAACACGCAGCGCGAAGTGGCTGCCCTGCGCCTGTGCCAGTCACACCCCAACGTG
GTGAATCTGCACGAGGTGCATCACGACCAGCTGCACACGTACCTGGTCCTGGAGCTGCTGCGGGGCGGGGAGCTGCTGGAGCACATCCGC
AAGAAGCGGCACTTCAGCGAGTCGGAAGCAAGCCAGATCCTGCGCAGCCTCGTGTCGGCCGTGAGCTTCATGCACGAGGAGGCGGGCGTG
GTGCACCGCGACCTCAAGCCGGAGAACATCCTGTACGCCGACGACACGCCCGGGGCCCCGGTGAAAATCATCGACTTCGGGTTCGCGCGG
TTGCGGCCGCAGAGTCCCGGGGTGCCCATGCAGACGCCCTGCTTCACGCTGCAGTACGCTGCCCCCGAGCTGCTGGCGCAGCAGGGCTAC
GACGAGTCCTGCGACCTCTGGAGCCTGGGCGTCATTCTGTACATGATGCTGTCGGGGCAGGTCCCCTTCCAGGGGGCCTCTGGCCAGGGC
GGGCAGAGCCAGGCGGCCGAGATCATGTGCAAAATCCGCGAGGGGCGCTTCTCCCTTGACGGGGAGGCCTGGCAGGGTGTATCCGAGGAA
GCCAAGGAGCTGGTCCGAGGGCTCCTGACCGTGGACCCCGCCAAGCGGCTGAAGCTCGAGGGACTGCGGGGCAGCTCGTGGCTGCAGGAC
GGCAGCGCGCGCTCCTCGCCCCCGCTCCGGACGCCCGACGTGCTCGAGTCCTCTGGGCCCGCAGTGCGCTCGGGTCTCAACGCCACCTTC
ATGGCATTCAACCGGGGCAAGCGGGAGGGCTTCTTCCTGAAGAGCGTGGAGAATGCACCCCTGGCCAAGCGGCGGAAGCAGAAGCTGCGG
AGCGCCACCGCCTCCCGCCGGGGCTCCCCTGCACCAGCCAACCCGGGCCGAGCCCCCGTCGCCTCCAAAGGGGCCCCCCGCCGAGCCAAC
GGCCCCCTGCCCCCCTCCTAATCCCCACCACTGTGACCCCCTTCCCTCATAGGGGCTGTGACCTGGGAGCCCGGCTCACTCCCGGAGGCC
TCTGCCTGCGGCTGACCTGATCCCCAAGGGACTGTCCTTTCCTCTCCTACCCCACCCCACTCCCAGACAGAGCAGAAGTATTTTTATAAG
CAGAGAATTTTTTATGTCTTACCAGATAGAGTTGCAGGGAAGGGGGGGCCTGCTGGGGAGTGGGGTTTGGGGGGCCCTCTCCCAGGACAC
TGCCTCTTCTGGGCAGAAGGCCCCTCCAGGGGGACTGCTCCAACAGGAAAGAGCCCCTCCCCCACTTCTAAGCACTGAGTTAGGAGTGCT
AACTCCTAAACTGGGACCCCCTACCCTGTTCTCCCCTGAGGCCCCGTTCCTGGGAGGGGCACCCCTCAACTGTCACTTTATGGACTGTCT
GTGCAATTACGTCCACCAAAGACCCGTGTTGGGGGTACTGAAGGAGAGGCCCTGGGGGACCCTCTGAAGCATTTCTGCCTCACTTTATGT
CATCTGCTTCTCCCCTGTTGGGGCTAAGGAAGGAGATAGGTGGCTCCTAAAAGAGGAGGCCATCTTCTCACCCACCCCTTCCTCTTTGGC
ACAGCTACTCCTGGCTGGGGGTGGGGCCTTGGGGGTCTGGGCTGGGCATCCATGGTCACTGCCTCAGCCCAGCCAGGCTGTGCCTTTGAC

>3122_3122_2_AHNAK-RPS6KA4_AHNAK_chr11_62259203_ENST00000257247_RPS6KA4_chr11_64132772_ENST00000334205_length(amino acids)=472AA_BP=1
MQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPSILFDHNNAVMTDGLEAPGAGDRPGR
AAVARSAMMQDSPFFQQYELDLREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTY
LVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPC
FTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPA
KRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAPLAKRRKQKLRSATASRRGSPAPAN

--------------------------------------------------------------
>3122_3122_3_AHNAK-RPS6KA4_AHNAK_chr11_62259203_ENST00000257247_RPS6KA4_chr11_64132772_ENST00000528057_length(transcript)=2805nt_BP=678nt
AGCTGCTCTGCCGCGGGGACTGCACCGCCCGCCCTGCCAGACCCGCCCGGAACGGGGCTCGTCGCCGCCAGTAGCCGCAGCACCGCAGCC
TTGGGCCTCGCGCCGGCTATGGCCGTGCCCTGGGGCTGAGCCCTCAGGTTGTGACCGAGATTCCCGACGAGAGAGACTGAGGGGAAGAGA
GGAAGGAGGGGCGGGCTCCTGGCAAGGCATTCGCTCCTGAGCGGAATCCTGCAAAGATGGAGAAGGAGGAGACAACCCGGGAGCTGCTGC
TGCCCAACTGGCAGGGTAGTGGCTCCCACGGGCTGACCATCGCCCAGAGGGACGACGGCGTCTTTGTGCAGGAGGTGACGCAGAACTCCC
CTGCGGCCCGCACTGGGGTGGTCAAGGAGGGGGACCAGATTGTGGGTGCCACCATCTACTTTGACAACCTGCAGTCGGGTGAGGTGACCC
AGCTGCTGAACACCATGGGGCACCACACGGTGGGCCTGAAGCTGCACCGCAAGGGGGACCGCTCTCCCGAGCCTGGCCAGACCTGGACCC
GTGAAGTCTTCAGCTCCTGCAGCTCTGAAGTGGTTCTGAACACACCACAGCCATCAGCACTGGAATGCAAAGACCAGAACAAACAGAAGG
AAGCCAGCAGCCAAGCCGGGGCAGTTTCAGTCTCCACCCCAAATGCAGGGCCTCGATTGGGTGGCTCTGGCTGCCAGGAAGATTCCAGCC
CCATTCCGGCCCCAAATCCGCTCAGAGCTGGATGTGGGCAACTTTGCGGAGGAATTCACTCGGCTGGAGCCTGTCTACTCACCCCCTGGC
AGCCCCCCACCTGGGGACCCCCGAATCTTTCAGGGATACTCCTTTGTGGCACCCTCCATTCTCTTTGACCACAACAACGCGGTGATGACC
GATGGGCTGGAAGCGCCTGGTGCTGGAGACCGGCCAGGTCGGGCAGCGGTGGCCAGGAGCGCTATGATGCAGTACGAGCTGGACCTGCGG
GAGCCTGCGCTGGGCCAGGGCAGCTTTTCTGTGTGTCGCCGCTGCCGCCAGCGCCAGAGCGGCCAGGAGTTCGCAGTCAAGATCCTCAGT
CGCAGGCTGGAGGCGAACACGCAGCGCGAAGTGGCTGCCCTGCGCCTGTGCCAGTCACACCCCAACGTGGTGAATCTGCACGAGGTGCAT
CACGACCAGCTGCACACGTACCTGGTCCTGGAGCTGCTGCGGGGCGGGGAGCTGCTGGAGCACATCCGCAAGAAGCGGCACTTCAGCGAG
TCGGAAGCAAGCCAGATCCTGCGCAGCCTCGTGTCGGCCGTGAGCTTCATGCACGAGGAGGCGGGCGTGGTGCACCGCGACCTCAAGCCG
GAGAACATCCTGTACGCCGACGACACGCCCGGGGCCCCGGTGAAAATCATCGACTTCGGGTTCGCGCGGTTGCGGCCGCAGAGTCCCGGG
GTGCCCATGCAGACGCCCTGCTTCACGCTGCAGTACGCTGCCCCCGAGCTGCTGGCGCAGCAGGGCTACGACGAGTCCTGCGACCTCTGG
AGCCTGGGCGTCATTCTGTACATGATGCTGTCGGGGCAGGTCCCCTTCCAGGGGGCCTCTGGCCAGGGCGGGCAGAGCCAGGCGGCCGAG
ATCATGTGCAAAATCCGCGAGGGGCGCTTCTCCCTTGACGGGGAGGCCTGGCAGGGTGTATCCGAGGAAGCCAAGGAGCTGGTCCGAGGG
CTCCTGACCGTGGACCCCGCCAAGCGGCTGAAGCTCGAGGGACTGCGGGGCAGCTCGTGGCTGCAGGACGGCAGCGCGCGCTCCTCGCCC
CCGCTCCGGACGCCCGACGTGCTCGAGTCCTCTGGGCCCGCAGTGCGCTCGGGTCTCAACGCCACCTTCATGGCATTCAACCGGGGCAAG
CGGGAGGGCTTCTTCCTGAAGAGCGTGGAGAATGCACCCCTGGCCAAGCGGCGGAAGCAGAAGCTGCGGAGCGCCACCGCCTCCCGCCGG
GGCTCCCCTGCACCAGCCAACCCGGGCCGAGCCCCCGTCGCCTCCAAAGGGGCCCCCCGCCGAGCCAACGGCCCCCTGCCCCCCTCCTAA
TCCCCACCACTGTGACCCCCTTCCCTCATAGGGGCTGTGACCTGGGAGCCCGGCTCACTCCCGGAGGCCTCTGCCTGCGGCTGACCTGAT
CCCCAAGGGACTGTCCTTTCCTCTCCTACCCCACCCCACTCCCAGACAGAGCAGAAGTATTTTTATAAGCAGAGAATTTTTTATGTCTTA
CCAGATAGAGTTGCAGGGAAGGGGGGGCCTGCTGGGGAGTGGGGTTTGGGGGGCCCTCTCCCAGGACACTGCCTCTTCTGGGCAGAAGGC
CCCTCCAGGGGGACTGCTCCAACAGGAAAGAGCCCCTCCCCCACTTCTAAGCACTGAGTTAGGAGTGCTAACTCCTAAACTGGGACCCCC
TACCCTGTTCTCCCCTGAGGCCCCGTTCCTGGGAGGGGCACCCCTCAACTGTCACTTTATGGACTGTCTGTGCAATTACGTCCACCAAAG
ACCCGTGTTGGGGGTACTGAAGGAGAGGCCCTGGGGGACCCTCTGAAGCATTTCTGCCTCACTTTATGTCATCTGCTTCTCCCCTGTTGG
GGCTAAGGAAGGAGATAGGTGGCTCCTAAAAGAGGAGGCCATCTTCTCACCCACCCCTTCCTCTTTGGCACAGCTACTCCTGGCTGGGGG
TGGGGCCTTGGGGGTCTGGGCTGGGCATCCATGGTCACTGCCTCAGCCCAGCCAGGCTGTGCCTTTGACTTTAAAATAAAAGTCCACCCA

>3122_3122_3_AHNAK-RPS6KA4_AHNAK_chr11_62259203_ENST00000257247_RPS6KA4_chr11_64132772_ENST00000528057_length(amino acids)=465AA_BP=1
MQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPSILFDHNNAVMTDGLEAPGAGDRPGR
AAVARSAMMQYELDLREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLR
GGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAA
PELLAQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEG
LRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAPLAKRRKQKLRSATASRRGSPAPANPGRAPVA

--------------------------------------------------------------
>3122_3122_4_AHNAK-RPS6KA4_AHNAK_chr11_62259204_ENST00000257247_RPS6KA4_chr11_64132773_ENST00000294261_length(transcript)=2081nt_BP=678nt
AGCTGCTCTGCCGCGGGGACTGCACCGCCCGCCCTGCCAGACCCGCCCGGAACGGGGCTCGTCGCCGCCAGTAGCCGCAGCACCGCAGCC
TTGGGCCTCGCGCCGGCTATGGCCGTGCCCTGGGGCTGAGCCCTCAGGTTGTGACCGAGATTCCCGACGAGAGAGACTGAGGGGAAGAGA
GGAAGGAGGGGCGGGCTCCTGGCAAGGCATTCGCTCCTGAGCGGAATCCTGCAAAGATGGAGAAGGAGGAGACAACCCGGGAGCTGCTGC
TGCCCAACTGGCAGGGTAGTGGCTCCCACGGGCTGACCATCGCCCAGAGGGACGACGGCGTCTTTGTGCAGGAGGTGACGCAGAACTCCC
CTGCGGCCCGCACTGGGGTGGTCAAGGAGGGGGACCAGATTGTGGGTGCCACCATCTACTTTGACAACCTGCAGTCGGGTGAGGTGACCC
AGCTGCTGAACACCATGGGGCACCACACGGTGGGCCTGAAGCTGCACCGCAAGGGGGACCGCTCTCCCGAGCCTGGCCAGACCTGGACCC
GTGAAGTCTTCAGCTCCTGCAGCTCTGAAGTGGTTCTGAACACACCACAGCCATCAGCACTGGAATGCAAAGACCAGAACAAACAGAAGG
AAGCCAGCAGCCAAGCCGGGGCAGTTTCAGTCTCCACCCCAAATGCAGGGCCTCGATTGGGTGGCTCTGGCTGCCAGGAAGATTCCAGCC
CCATTCCGGCCCCAAATCCGCTCAGAGCTGGATGTGGGCAACTTTGCGGAGGAATTCACTCGGCTGGAGCCTGTCTACTCACCCCCTGGC
AGCCCCCCACCTGGGGACCCCCGAATCTTTCAGGGATACTCCTTTGTGGCACCCTCCATTCTCTTTGACCACAACAACGCGGCCGAGATC
ATGTGCAAAATCCGCGAGGGGCGCTTCTCCCTTGACGGGGAGGCCTGGCAGGGTGTATCCGAGGAAGCCAAGGAGCTGGTCCGAGGGCTC
CTGACCGTGGACCCCGCCAAGCGGCTGAAGCTCGAGGGACTGCGGGGCAGCTCGTGGCTGCAGGACGGCAGCGCGCGCTCCTCGCCCCCG
CTCCGGACGCCCGACGTGCTCGAGTCCTCTGGGCCCGCAGTGCGCTCGGGTCTCAACGCCACCTTCATGGCATTCAACCGGGGCAAGCGG
GAGGGCTTCTTCCTGAAGAGCGTGGAGAATGCACCCCTGGCCAAGCGGCGGAAGCAGAAGCTGCGGAGCGCCACCGCCTCCCGCCGGGGC
TCCCCTGCACCAGCCAACCCGGGCCGAGCCCCCGTCGCCTCCAAAGGGGCCCCCCGCCGAGCCAACGGCCCCCTGCCCCCCTCCTAATCC
CCACCACTGTGACCCCCTTCCCTCATAGGGGCTGTGACCTGGGAGCCCGGCTCACTCCCGGAGGCCTCTGCCTGCGGCTGACCTGATCCC
CAAGGGACTGTCCTTTCCTCTCCTACCCCACCCCACTCCCAGACAGAGCAGAAGTATTTTTATAAGCAGAGAATTTTTTATGTCTTACCA
GATAGAGTTGCAGGGAAGGGGGGGCCTGCTGGGGAGTGGGGTTTGGGGGGCCCTCTCCCAGGACACTGCCTCTTCTGGGCAGAAGGCCCC
TCCAGGGGGACTGCTCCAACAGGAAAGAGCCCCTCCCCCACTTCTAAGCACTGAGTTAGGAGTGCTAACTCCTAAACTGGGACCCCCTAC
CCTGTTCTCCCCTGAGGCCCCGTTCCTGGGAGGGGCACCCCTCAACTGTCACTTTATGGACTGTCTGTGCAATTACGTCCACCAAAGACC
CGTGTTGGGGGTACTGAAGGAGAGGCCCTGGGGGACCCTCTGAAGCATTTCTGCCTCACTTTATGTCATCTGCTTCTCCCCTGTTGGGGC
TAAGGAAGGAGATAGGTGGCTCCTAAAAGAGGAGGCCATCTTCTCACCCACCCCTTCCTCTTTGGCACAGCTACTCCTGGCTGGGGGTGG
GGCCTTGGGGGTCTGGGCTGGGCATCCATGGTCACTGCCTCAGCCCAGCCAGGCTGTGCCTTTGACTTTAAAATAAAAGTCCACCCAGTG

>3122_3122_4_AHNAK-RPS6KA4_AHNAK_chr11_62259204_ENST00000257247_RPS6KA4_chr11_64132773_ENST00000294261_length(amino acids)=224AA_BP=1
MQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPSILFDHNNAAEIMCKIREGRFSLDGE
AWQGVSEEAKELVRGLLTVDPAKRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAPLA

--------------------------------------------------------------
>3122_3122_5_AHNAK-RPS6KA4_AHNAK_chr11_62259204_ENST00000257247_RPS6KA4_chr11_64132773_ENST00000334205_length(transcript)=2826nt_BP=678nt
AGCTGCTCTGCCGCGGGGACTGCACCGCCCGCCCTGCCAGACCCGCCCGGAACGGGGCTCGTCGCCGCCAGTAGCCGCAGCACCGCAGCC
TTGGGCCTCGCGCCGGCTATGGCCGTGCCCTGGGGCTGAGCCCTCAGGTTGTGACCGAGATTCCCGACGAGAGAGACTGAGGGGAAGAGA
GGAAGGAGGGGCGGGCTCCTGGCAAGGCATTCGCTCCTGAGCGGAATCCTGCAAAGATGGAGAAGGAGGAGACAACCCGGGAGCTGCTGC
TGCCCAACTGGCAGGGTAGTGGCTCCCACGGGCTGACCATCGCCCAGAGGGACGACGGCGTCTTTGTGCAGGAGGTGACGCAGAACTCCC
CTGCGGCCCGCACTGGGGTGGTCAAGGAGGGGGACCAGATTGTGGGTGCCACCATCTACTTTGACAACCTGCAGTCGGGTGAGGTGACCC
AGCTGCTGAACACCATGGGGCACCACACGGTGGGCCTGAAGCTGCACCGCAAGGGGGACCGCTCTCCCGAGCCTGGCCAGACCTGGACCC
GTGAAGTCTTCAGCTCCTGCAGCTCTGAAGTGGTTCTGAACACACCACAGCCATCAGCACTGGAATGCAAAGACCAGAACAAACAGAAGG
AAGCCAGCAGCCAAGCCGGGGCAGTTTCAGTCTCCACCCCAAATGCAGGGCCTCGATTGGGTGGCTCTGGCTGCCAGGAAGATTCCAGCC
CCATTCCGGCCCCAAATCCGCTCAGAGCTGGATGTGGGCAACTTTGCGGAGGAATTCACTCGGCTGGAGCCTGTCTACTCACCCCCTGGC
AGCCCCCCACCTGGGGACCCCCGAATCTTTCAGGGATACTCCTTTGTGGCACCCTCCATTCTCTTTGACCACAACAACGCGGTGATGACC
GATGGGCTGGAAGCGCCTGGTGCTGGAGACCGGCCAGGTCGGGCAGCGGTGGCCAGGAGCGCTATGATGCAGGACTCGCCCTTCTTCCAG
CAGTACGAGCTGGACCTGCGGGAGCCTGCGCTGGGCCAGGGCAGCTTTTCTGTGTGTCGCCGCTGCCGCCAGCGCCAGAGCGGCCAGGAG
TTCGCAGTCAAGATCCTCAGTCGCAGGCTGGAGGCGAACACGCAGCGCGAAGTGGCTGCCCTGCGCCTGTGCCAGTCACACCCCAACGTG
GTGAATCTGCACGAGGTGCATCACGACCAGCTGCACACGTACCTGGTCCTGGAGCTGCTGCGGGGCGGGGAGCTGCTGGAGCACATCCGC
AAGAAGCGGCACTTCAGCGAGTCGGAAGCAAGCCAGATCCTGCGCAGCCTCGTGTCGGCCGTGAGCTTCATGCACGAGGAGGCGGGCGTG
GTGCACCGCGACCTCAAGCCGGAGAACATCCTGTACGCCGACGACACGCCCGGGGCCCCGGTGAAAATCATCGACTTCGGGTTCGCGCGG
TTGCGGCCGCAGAGTCCCGGGGTGCCCATGCAGACGCCCTGCTTCACGCTGCAGTACGCTGCCCCCGAGCTGCTGGCGCAGCAGGGCTAC
GACGAGTCCTGCGACCTCTGGAGCCTGGGCGTCATTCTGTACATGATGCTGTCGGGGCAGGTCCCCTTCCAGGGGGCCTCTGGCCAGGGC
GGGCAGAGCCAGGCGGCCGAGATCATGTGCAAAATCCGCGAGGGGCGCTTCTCCCTTGACGGGGAGGCCTGGCAGGGTGTATCCGAGGAA
GCCAAGGAGCTGGTCCGAGGGCTCCTGACCGTGGACCCCGCCAAGCGGCTGAAGCTCGAGGGACTGCGGGGCAGCTCGTGGCTGCAGGAC
GGCAGCGCGCGCTCCTCGCCCCCGCTCCGGACGCCCGACGTGCTCGAGTCCTCTGGGCCCGCAGTGCGCTCGGGTCTCAACGCCACCTTC
ATGGCATTCAACCGGGGCAAGCGGGAGGGCTTCTTCCTGAAGAGCGTGGAGAATGCACCCCTGGCCAAGCGGCGGAAGCAGAAGCTGCGG
AGCGCCACCGCCTCCCGCCGGGGCTCCCCTGCACCAGCCAACCCGGGCCGAGCCCCCGTCGCCTCCAAAGGGGCCCCCCGCCGAGCCAAC
GGCCCCCTGCCCCCCTCCTAATCCCCACCACTGTGACCCCCTTCCCTCATAGGGGCTGTGACCTGGGAGCCCGGCTCACTCCCGGAGGCC
TCTGCCTGCGGCTGACCTGATCCCCAAGGGACTGTCCTTTCCTCTCCTACCCCACCCCACTCCCAGACAGAGCAGAAGTATTTTTATAAG
CAGAGAATTTTTTATGTCTTACCAGATAGAGTTGCAGGGAAGGGGGGGCCTGCTGGGGAGTGGGGTTTGGGGGGCCCTCTCCCAGGACAC
TGCCTCTTCTGGGCAGAAGGCCCCTCCAGGGGGACTGCTCCAACAGGAAAGAGCCCCTCCCCCACTTCTAAGCACTGAGTTAGGAGTGCT
AACTCCTAAACTGGGACCCCCTACCCTGTTCTCCCCTGAGGCCCCGTTCCTGGGAGGGGCACCCCTCAACTGTCACTTTATGGACTGTCT
GTGCAATTACGTCCACCAAAGACCCGTGTTGGGGGTACTGAAGGAGAGGCCCTGGGGGACCCTCTGAAGCATTTCTGCCTCACTTTATGT
CATCTGCTTCTCCCCTGTTGGGGCTAAGGAAGGAGATAGGTGGCTCCTAAAAGAGGAGGCCATCTTCTCACCCACCCCTTCCTCTTTGGC
ACAGCTACTCCTGGCTGGGGGTGGGGCCTTGGGGGTCTGGGCTGGGCATCCATGGTCACTGCCTCAGCCCAGCCAGGCTGTGCCTTTGAC

>3122_3122_5_AHNAK-RPS6KA4_AHNAK_chr11_62259204_ENST00000257247_RPS6KA4_chr11_64132773_ENST00000334205_length(amino acids)=472AA_BP=1
MQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPSILFDHNNAVMTDGLEAPGAGDRPGR
AAVARSAMMQDSPFFQQYELDLREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTY
LVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPC
FTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPA
KRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAPLAKRRKQKLRSATASRRGSPAPAN

--------------------------------------------------------------
>3122_3122_6_AHNAK-RPS6KA4_AHNAK_chr11_62259204_ENST00000257247_RPS6KA4_chr11_64132773_ENST00000528057_length(transcript)=2805nt_BP=678nt
AGCTGCTCTGCCGCGGGGACTGCACCGCCCGCCCTGCCAGACCCGCCCGGAACGGGGCTCGTCGCCGCCAGTAGCCGCAGCACCGCAGCC
TTGGGCCTCGCGCCGGCTATGGCCGTGCCCTGGGGCTGAGCCCTCAGGTTGTGACCGAGATTCCCGACGAGAGAGACTGAGGGGAAGAGA
GGAAGGAGGGGCGGGCTCCTGGCAAGGCATTCGCTCCTGAGCGGAATCCTGCAAAGATGGAGAAGGAGGAGACAACCCGGGAGCTGCTGC
TGCCCAACTGGCAGGGTAGTGGCTCCCACGGGCTGACCATCGCCCAGAGGGACGACGGCGTCTTTGTGCAGGAGGTGACGCAGAACTCCC
CTGCGGCCCGCACTGGGGTGGTCAAGGAGGGGGACCAGATTGTGGGTGCCACCATCTACTTTGACAACCTGCAGTCGGGTGAGGTGACCC
AGCTGCTGAACACCATGGGGCACCACACGGTGGGCCTGAAGCTGCACCGCAAGGGGGACCGCTCTCCCGAGCCTGGCCAGACCTGGACCC
GTGAAGTCTTCAGCTCCTGCAGCTCTGAAGTGGTTCTGAACACACCACAGCCATCAGCACTGGAATGCAAAGACCAGAACAAACAGAAGG
AAGCCAGCAGCCAAGCCGGGGCAGTTTCAGTCTCCACCCCAAATGCAGGGCCTCGATTGGGTGGCTCTGGCTGCCAGGAAGATTCCAGCC
CCATTCCGGCCCCAAATCCGCTCAGAGCTGGATGTGGGCAACTTTGCGGAGGAATTCACTCGGCTGGAGCCTGTCTACTCACCCCCTGGC
AGCCCCCCACCTGGGGACCCCCGAATCTTTCAGGGATACTCCTTTGTGGCACCCTCCATTCTCTTTGACCACAACAACGCGGTGATGACC
GATGGGCTGGAAGCGCCTGGTGCTGGAGACCGGCCAGGTCGGGCAGCGGTGGCCAGGAGCGCTATGATGCAGTACGAGCTGGACCTGCGG
GAGCCTGCGCTGGGCCAGGGCAGCTTTTCTGTGTGTCGCCGCTGCCGCCAGCGCCAGAGCGGCCAGGAGTTCGCAGTCAAGATCCTCAGT
CGCAGGCTGGAGGCGAACACGCAGCGCGAAGTGGCTGCCCTGCGCCTGTGCCAGTCACACCCCAACGTGGTGAATCTGCACGAGGTGCAT
CACGACCAGCTGCACACGTACCTGGTCCTGGAGCTGCTGCGGGGCGGGGAGCTGCTGGAGCACATCCGCAAGAAGCGGCACTTCAGCGAG
TCGGAAGCAAGCCAGATCCTGCGCAGCCTCGTGTCGGCCGTGAGCTTCATGCACGAGGAGGCGGGCGTGGTGCACCGCGACCTCAAGCCG
GAGAACATCCTGTACGCCGACGACACGCCCGGGGCCCCGGTGAAAATCATCGACTTCGGGTTCGCGCGGTTGCGGCCGCAGAGTCCCGGG
GTGCCCATGCAGACGCCCTGCTTCACGCTGCAGTACGCTGCCCCCGAGCTGCTGGCGCAGCAGGGCTACGACGAGTCCTGCGACCTCTGG
AGCCTGGGCGTCATTCTGTACATGATGCTGTCGGGGCAGGTCCCCTTCCAGGGGGCCTCTGGCCAGGGCGGGCAGAGCCAGGCGGCCGAG
ATCATGTGCAAAATCCGCGAGGGGCGCTTCTCCCTTGACGGGGAGGCCTGGCAGGGTGTATCCGAGGAAGCCAAGGAGCTGGTCCGAGGG
CTCCTGACCGTGGACCCCGCCAAGCGGCTGAAGCTCGAGGGACTGCGGGGCAGCTCGTGGCTGCAGGACGGCAGCGCGCGCTCCTCGCCC
CCGCTCCGGACGCCCGACGTGCTCGAGTCCTCTGGGCCCGCAGTGCGCTCGGGTCTCAACGCCACCTTCATGGCATTCAACCGGGGCAAG
CGGGAGGGCTTCTTCCTGAAGAGCGTGGAGAATGCACCCCTGGCCAAGCGGCGGAAGCAGAAGCTGCGGAGCGCCACCGCCTCCCGCCGG
GGCTCCCCTGCACCAGCCAACCCGGGCCGAGCCCCCGTCGCCTCCAAAGGGGCCCCCCGCCGAGCCAACGGCCCCCTGCCCCCCTCCTAA
TCCCCACCACTGTGACCCCCTTCCCTCATAGGGGCTGTGACCTGGGAGCCCGGCTCACTCCCGGAGGCCTCTGCCTGCGGCTGACCTGAT
CCCCAAGGGACTGTCCTTTCCTCTCCTACCCCACCCCACTCCCAGACAGAGCAGAAGTATTTTTATAAGCAGAGAATTTTTTATGTCTTA
CCAGATAGAGTTGCAGGGAAGGGGGGGCCTGCTGGGGAGTGGGGTTTGGGGGGCCCTCTCCCAGGACACTGCCTCTTCTGGGCAGAAGGC
CCCTCCAGGGGGACTGCTCCAACAGGAAAGAGCCCCTCCCCCACTTCTAAGCACTGAGTTAGGAGTGCTAACTCCTAAACTGGGACCCCC
TACCCTGTTCTCCCCTGAGGCCCCGTTCCTGGGAGGGGCACCCCTCAACTGTCACTTTATGGACTGTCTGTGCAATTACGTCCACCAAAG
ACCCGTGTTGGGGGTACTGAAGGAGAGGCCCTGGGGGACCCTCTGAAGCATTTCTGCCTCACTTTATGTCATCTGCTTCTCCCCTGTTGG
GGCTAAGGAAGGAGATAGGTGGCTCCTAAAAGAGGAGGCCATCTTCTCACCCACCCCTTCCTCTTTGGCACAGCTACTCCTGGCTGGGGG
TGGGGCCTTGGGGGTCTGGGCTGGGCATCCATGGTCACTGCCTCAGCCCAGCCAGGCTGTGCCTTTGACTTTAAAATAAAAGTCCACCCA

>3122_3122_6_AHNAK-RPS6KA4_AHNAK_chr11_62259204_ENST00000257247_RPS6KA4_chr11_64132773_ENST00000528057_length(amino acids)=465AA_BP=1
MQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPSILFDHNNAVMTDGLEAPGAGDRPGR
AAVARSAMMQYELDLREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLR
GGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAA
PELLAQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEG
LRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAPLAKRRKQKLRSATASRRGSPAPANPGRAPVA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for AHNAK-RPS6KA4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AHNAK-RPS6KA4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AHNAK-RPS6KA4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAHNAKC0007134Renal Cell Carcinoma1CTD_human
HgeneAHNAKC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneAHNAKC0027626Neoplasm Invasiveness1CTD_human
HgeneAHNAKC0263454Chloracne1CTD_human
HgeneAHNAKC0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
HgeneAHNAKC1266042Chromophobe Renal Cell Carcinoma1CTD_human
HgeneAHNAKC1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
HgeneAHNAKC1266044Collecting Duct Carcinoma of the Kidney1CTD_human
HgeneAHNAKC1306837Papillary Renal Cell Carcinoma1CTD_human