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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ALG8-SNX29 (FusionGDB2 ID:HG79053TG92017)

Fusion Gene Summary for ALG8-SNX29

check button Fusion gene summary
Fusion gene informationFusion gene name: ALG8-SNX29
Fusion gene ID: hg79053tg92017
HgeneTgene
Gene symbol

ALG8

SNX29

Gene ID

79053

92017

Gene nameALG8 alpha-1,3-glucosyltransferasesorting nexin 29
SynonymsCDG1H|PCLD3A-388D4.1|RUNDC2A
Cytomap('ALG8')('SNX29')

11q14.1

16p13.13-p13.12

Type of geneprotein-codingprotein-coding
Descriptionprobable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferaseHUSSY-02asparagine-linked glycosylation 8 alpha-13-glucosyltransferase-like proteinasparagine-linked glycosylation 8 homolog (S. cerevisiae, alpha-1,3-glucosyltransferase)aspsorting nexin-29RUN domain containing 2ARUN domain-containing protein 2A
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000299626, ENST00000376156, 
ENST00000532552, 
Fusion gene scores* DoF score6 X 7 X 4=16815 X 15 X 6=1350
# samples 716
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1350*10)=-3.07681559705083
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ALG8 [Title/Abstract] AND SNX29 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointALG8(77835067)-SNX29(12497305), # samples:2
Anticipated loss of major functional domain due to fusion event.ALG8-SNX29 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ALG8-SNX29 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ALG8-SNX29 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ALG8-SNX29 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ALG8-SNX29 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ALG8-SNX29 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ALG8-SNX29 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ALG8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SNX29 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-RD-A8MW-01AALG8chr11

77830228

-SNX29chr16

12497305

+
ChimerDB4STADTCGA-RD-A8MW-01AALG8chr11

77835067

-SNX29chr16

12497305

+


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Fusion Gene ORF analysis for ALG8-SNX29

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000299626ENST00000568359ALG8chr11

77830228

-SNX29chr16

12497305

+
5CDS-intronENST00000299626ENST00000568359ALG8chr11

77835067

-SNX29chr16

12497305

+
5CDS-intronENST00000376156ENST00000568359ALG8chr11

77830228

-SNX29chr16

12497305

+
5CDS-intronENST00000376156ENST00000568359ALG8chr11

77835067

-SNX29chr16

12497305

+
Frame-shiftENST00000299626ENST00000306030ALG8chr11

77830228

-SNX29chr16

12497305

+
Frame-shiftENST00000299626ENST00000323433ALG8chr11

77830228

-SNX29chr16

12497305

+
Frame-shiftENST00000299626ENST00000566228ALG8chr11

77830228

-SNX29chr16

12497305

+
Frame-shiftENST00000376156ENST00000306030ALG8chr11

77830228

-SNX29chr16

12497305

+
Frame-shiftENST00000376156ENST00000306030ALG8chr11

77835067

-SNX29chr16

12497305

+
Frame-shiftENST00000376156ENST00000323433ALG8chr11

77830228

-SNX29chr16

12497305

+
Frame-shiftENST00000376156ENST00000323433ALG8chr11

77835067

-SNX29chr16

12497305

+
Frame-shiftENST00000376156ENST00000566228ALG8chr11

77830228

-SNX29chr16

12497305

+
Frame-shiftENST00000376156ENST00000566228ALG8chr11

77835067

-SNX29chr16

12497305

+
In-frameENST00000299626ENST00000306030ALG8chr11

77835067

-SNX29chr16

12497305

+
In-frameENST00000299626ENST00000323433ALG8chr11

77835067

-SNX29chr16

12497305

+
In-frameENST00000299626ENST00000566228ALG8chr11

77835067

-SNX29chr16

12497305

+
intron-3CDSENST00000532552ENST00000306030ALG8chr11

77830228

-SNX29chr16

12497305

+
intron-3CDSENST00000532552ENST00000306030ALG8chr11

77835067

-SNX29chr16

12497305

+
intron-3CDSENST00000532552ENST00000323433ALG8chr11

77830228

-SNX29chr16

12497305

+
intron-3CDSENST00000532552ENST00000323433ALG8chr11

77835067

-SNX29chr16

12497305

+
intron-3CDSENST00000532552ENST00000566228ALG8chr11

77830228

-SNX29chr16

12497305

+
intron-3CDSENST00000532552ENST00000566228ALG8chr11

77835067

-SNX29chr16

12497305

+
intron-intronENST00000532552ENST00000568359ALG8chr11

77830228

-SNX29chr16

12497305

+
intron-intronENST00000532552ENST00000568359ALG8chr11

77835067

-SNX29chr16

12497305

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000299626ALG8chr1177835067-ENST00000566228SNX29chr1612497305+658744072926284
ENST00000299626ALG8chr1177835067-ENST00000323433SNX29chr1612497305+86744072866264
ENST00000299626ALG8chr1177835067-ENST00000306030SNX29chr1612497305+658644072926284

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000299626ENST00000566228ALG8chr1177835067-SNX29chr1612497305+0.0059546360.9940454
ENST00000299626ENST00000323433ALG8chr1177835067-SNX29chr1612497305+0.0043624590.9956376
ENST00000299626ENST00000306030ALG8chr1177835067-SNX29chr1612497305+0.0060905270.9939095

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Fusion Genomic Features for ALG8-SNX29


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ALG8chr1177830227-SNX29chr1612497304+2.65E-070.99999976
ALG8chr1177835066-SNX29chr1612497304+8.09E-111
ALG8chr1177830227-SNX29chr1612497304+2.65E-070.99999976
ALG8chr1177835066-SNX29chr1612497304+8.09E-111

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ALG8-SNX29


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:77835067/chr16:12497305)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneALG8chr11:77835067chr16:12497305ENST00000299626-313103_122122527.0TransmembraneHelical
HgeneALG8chr11:77835067chr16:12497305ENST00000299626-3134_24122527.0TransmembraneHelical
HgeneALG8chr11:77835067chr16:12497305ENST00000376156-314103_122122516.6666666666666TransmembraneHelical
HgeneALG8chr11:77835067chr16:12497305ENST00000376156-3144_24122516.6666666666666TransmembraneHelical
TgeneSNX29chr11:77835067chr16:12497305ENST000005662281621656_779651814.0DomainPX

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneALG8chr11:77835067chr16:12497305ENST00000299626-313143_163122527.0TransmembraneHelical
HgeneALG8chr11:77835067chr16:12497305ENST00000299626-313188_208122527.0TransmembraneHelical
HgeneALG8chr11:77835067chr16:12497305ENST00000299626-313238_258122527.0TransmembraneHelical
HgeneALG8chr11:77835067chr16:12497305ENST00000299626-313334_354122527.0TransmembraneHelical
HgeneALG8chr11:77835067chr16:12497305ENST00000299626-313368_388122527.0TransmembraneHelical
HgeneALG8chr11:77835067chr16:12497305ENST00000299626-313389_409122527.0TransmembraneHelical
HgeneALG8chr11:77835067chr16:12497305ENST00000299626-313427_449122527.0TransmembraneHelical
HgeneALG8chr11:77835067chr16:12497305ENST00000299626-313461_481122527.0TransmembraneHelical
HgeneALG8chr11:77835067chr16:12497305ENST00000299626-313488_508122527.0TransmembraneHelical
HgeneALG8chr11:77835067chr16:12497305ENST00000376156-314143_163122516.6666666666666TransmembraneHelical
HgeneALG8chr11:77835067chr16:12497305ENST00000376156-314188_208122516.6666666666666TransmembraneHelical
HgeneALG8chr11:77835067chr16:12497305ENST00000376156-314238_258122516.6666666666666TransmembraneHelical
HgeneALG8chr11:77835067chr16:12497305ENST00000376156-314334_354122516.6666666666666TransmembraneHelical
HgeneALG8chr11:77835067chr16:12497305ENST00000376156-314368_388122516.6666666666666TransmembraneHelical
HgeneALG8chr11:77835067chr16:12497305ENST00000376156-314389_409122516.6666666666666TransmembraneHelical
HgeneALG8chr11:77835067chr16:12497305ENST00000376156-314427_449122516.6666666666666TransmembraneHelical
HgeneALG8chr11:77835067chr16:12497305ENST00000376156-314461_481122516.6666666666666TransmembraneHelical
HgeneALG8chr11:77835067chr16:12497305ENST00000376156-314488_508122516.6666666666666TransmembraneHelical
TgeneSNX29chr11:77835067chr16:12497305ENST000005662281621466_545651814.0Coiled coilOntology_term=ECO:0000255
TgeneSNX29chr11:77835067chr16:12497305ENST00000566228162136_180651814.0DomainRUN


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Fusion Gene Sequence for ALG8-SNX29


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4039_4039_1_ALG8-SNX29_ALG8_chr11_77835067_ENST00000299626_SNX29_chr16_12497305_ENST00000306030_length(transcript)=6586nt_BP=440nt
AGAGGGCTTTCTCCGCATGCGCGGGATCCCGGATGTGGATCAAGTTGGTGGGAAGCGTGCGGTGCCGCAGCAATGGCGGCGCTCACAATT
GCCACGGGTACTGGCAATTGGTTTTCGGCTTTGGCGCTCGGGGTGACTCTTCTCAAATGCCTTCTCATCCCCACATACCATTCCACAGAT
TTTGAAGTACACCGAAACTGGCTTGCTATCACTCACAGTTTGCCAATATCACAGTGGTATTATGAGGCAACTTCAGAGTGGACGTTGGAT
TACCCCCCTTTCTTTGCATGGTTTGAGTATATCCTGTCACATGTTGCCAAATATTTTGATCAAGAAATGCTGAATGTCCATAATTTGAAT
TACTCCAGCTCAAGGACCTTACTTTTCCAGAGATTTTCCGTCATCTTTATGGATGTACTCTTTGTGTATGCTGTCCGTGAATCAAACCGG
GCGCTGATCAACGTCTGGATCCCCTCAGTGTTTCTCCGGGGCAAAGCAGCAAATGCATTCCACGTGTATCAGGTCTACATCCGGATAAAA
GACGATGAATGGAATATTTATCGCCGGTATACAGAGTTCAGGAGTTTGCACCACAAGTTACAAAACAAGTACCCTCAAGTGAGGGCCTAC
AACTTCCCACCCAAAAAGGCCATTGGAAACAAGGATGCCAAGTTTGTGGAGGAACGGAGAAAGCAGCTCCAGAATTACCTGCGCAGCGTC
ATGAACAAAGTCATCCAGATGGTCCCCGAGTTCGCTGCCAGCCCCAAGAAGGAGACCCTCATCCAGCTGATGCCCTTCTTCGTCGACATC
ACCCCGCCCGGAGAGCCTGTGAACAGCCGGCCCAAAGCAGCTTCCCGCTTCCCCAAACTGTCCCGGGGTCAGCCCCGGGAGACCCGCAAC
GTGGAGCCCCAGAGCGGTGACCTCTGACCTCGACAAAACCGCAGCCACGGGCCCTGTGCGTGGCACCAGCTGCGTCCACCCCAGCCACTG
CCGCTGGCCCCTCACCTCAGCGTGACAACCACGTCCACCTGGTGATCCTGAGAGCACACGATTCCCAACAGTTACACAACACCCCGATTA
AACTAATCAGTCTTCGAGCCGCATGATACCGTGACCCGAGAGACCAAGGCAGCACCTCGCTGGAGAGACTGGGACACACAGTCCTTCTGC
TTCTGGGGTCTACCCTGGGCTGCAAGGGCTGTTCCTCCACCTTTCTGTAGTTCAGGGCTGGCAGGAGGGTGGGCACCAGGTCAGGCTGGG
TGCGCCATGGTTGAGAGGCAAAGGTGATCCCCTATATAGGAAGGTTCATGCAGAGCCAGCCTCTCCACTCTTTCCCACGTGGGGACTAGA
ATGACTATTAGCCTCTCCTTTTGCTTTTTAAGGTTATTACCTGGCCTAACCTAGGGATGGCTGGCTTTGCGGGGGGGGGGGGGGGGGGGG
GCATGGTTCCTTTCACTGCATTTTCCACCAACAGTCATTAGACACCTGGCACTGTCACAGCTCACTTTTCCAGAGGGATATTCCTGTGGC
TTTGGCAAGGAGCCATTAGTGATGTGCAACTTGAGTTCAGAGAACTTCCCCTACCTCCCCCATGGCTGGCTTCAGGAAGGACCAGTGCCC
TCCATAGCCTGAGGCCACCTAGGCCCTCGCCAGGCTTGGAGTGGGGGGACTCAGACATCTGGCCCAGCCATCAGCAGCAACCTAGTAACC
CGGCGTCATCCAGCGTGTCCAAAGTAGCATTGGCCCTACAGTCATGAGAGACTTGGGTCAGGGAACCACTGCAGAAGGTTCCAGGGTTTT
CAAACCAGGCTCCATGACTATGAAGTTGGACCCAGTGTGGACACTTAACAGATCATGTGTCTCTCCACTAAAAACATTTTCCATCCCGTC
TGCCCCCGACATTGTCCTTGATAACAGAACTCTGCATCCCCTAAGACAGAGTCCTCTGTTCCTCCCATGTCAGGTGGCTCTCAGAGTACA
GGGACCTTGGCAGGTGGAGAGGAGGATGGGGACCAGCAGCTGGGCAGCCCCCAGGGCTCCTCCTCCAGTGAGCTCACATCAGAGCACCTC
ACAGAGCAATAGCCGTCCTCAGATGCTCAGCAAAGTTGTGGCAGTTTGCATTTCTAGGGTAAACTAACTAGGAAGGATGTCGTGAAATGG
ACTATGCAAGAGTAAGTTTGTGTGTTTCGCCTTAATCTGAGGCAGAGACACAGCAGAACCTGAGGAGAAAAGCAGGTGGAAGGTGACGGT
TAGATGGTAAGCCATGGGCTTGTCCTGGAACTGCTTCAACTCAGTGGCTTAAAATGAGAACTGCCCAGGTGAGCATGGAGCATCTCCTAG
GCTCGAGGACATCTCTGGAGAATCATCTGGAAGGTTTATACTGTGCCTTCCCCTCGTAGCAAAAAGGAAGATTGTTCATGGCCTTTAAGG
AAGGCTGAGATCACTCACACACAGCGCCCCCCCACCCCAGAGAAACCGAGTCAGCCTACATGACTTCCAAGGGGACCTGGGGCCAGATAA
GCCCTGCCCCGGTGAGACCAAATGAGCTGGAGCATGTATGGAGGTGCGGACCCTGCAGTCAGTTTGCGAGTGTGGAGGACCCGAGACATC
CTGTAAAGGCAACTTGGTCTCCCTCCCACTCACCTGCCAACATTGCTGCAATACACATGGTTTATCTGAAATTCCAAGGCCAGAGTGCAC
ATCAGCTCACATGACTGGCAACTCTAAATAGAGAGCCCTAATGGACTGAGGCAGGAAACGTCTAAAAGCTCAATCTGCTGTATGTCATGA
CCCCTTAGGTTGGGTTTATGCCACATCGGTCATTTTGAAGTAGGTGTTTGATGCCAGCTCAGAGACTGTCTCAGGAGTGCCTCCCTGGCC
TGGGTAGCTACCCTGGAGGTCATCTCCCTGTTCTCTGTTGGATAAAGGAACCTCCCCCATCTGTGACATTCCCTTGGGCCCAGGCTTATG
ACCTGCACCTTTTCTGACACCTGCCCCCAAAGCACAGGATGTGAATTGGTCTCTCTCCAGATACCCCACGAGGAAGCACCTTGGACATTC
TGCACATGATAATAATGCAACAGTCCCCCATTGCTGAGAGATACTAACCCGTGAGAAACAAGTATGCTCTCAGCTGGTATTGAACTGGTG
GGAGAAACTGCCTCCTACTTTTATAATACTGAATTATTCACAAAAAACCTGGTCTGCTCTCCAAAATGAGAGCATGTTCCTGGGAGCCAC
ATGGGGACCATCCCCAGCTGCCTGCTCCTGGTACCTCCCCCATGATCATGCACAGACCGTAGAGTCGAGTCATCTCGCAGATCCAGACCA
TCTCCTCTCATTCTCACTCTAAAAATGCTGGTGGCCCGCACATGACAGCAACTCCCCGAAGCCTTCCCTTTGGAATCCCATAGAATGTTC
TGCAATGATTGGGTCCATCTTGCTGCTCAGAAGAATCCCGTCCTGCTCTCTAGTGTGGTGGGATGAACTTCAGGCAACAAACAACTGGCA
GGGTTCCCAGTTCCTGGAGTTATGGAGCAGAAACACCCAGGCCTAGCAGAATTGTGGCTGAAACCTGGTGCCCAAATTCCACACCCTGGA
AATGTGTCAACTGCCTGTCAGCCTGGATTCAATTCTGAGGGCTAAGCCACGACCTTATCCATGAGTGGCGAAGACACCCCTGAGGAAAGG
ATTGCTTGCACCTCACATCTGTCTTCTTCTAAGATTACTCGGAGATTTTCAAACAACATCTGAGAACAGAAGCCCCCTCCCCTACTCAGA
GAGGAACGAGGGTGGCCCACCTCTCAAGGGCCTTGGATTCCTGGGACCACCCTTTGCTGGGAGGAAGAATCCACACCGAATCCTTCTGTC
TTCATGGCCTGCTGTGCTGAAACAGAACAGCAGGTTCCATCTTTCACATCTTTTTTTCTCCCCCAGATGAAAGACGACTCAGGAACGGTA
GGGCTGGGCAGAGGTGTCTCTCCTTGAGAGACAACAAAAGCTTCTAAGGGAGGGAGCTTAAAGGCTGCTAGAAACCTAGCCCAACCATCC
ACTCCTGATCTGAGACAGAACCTTCTCCGCCACTCTTCCTGCAATCAGTGTGAAATTCCAGCTTCTTTGATTCCCACTTAGCAGTATGCT
CCAATCACGTTGCTGGCAAGGCATTTTAGAGTTTGGAGCTGAGGTTCAAAGCCCCCTGCATTTCTCTACTGGCAGGCCCTGGTGAAGGAA
GACACTTTCAGGGAAGAGGCTCTTACAGTCTATGGTGGTAGCCATCTTCACATCCAGTCACCAGTTGCATCTAGGGAGCTGCTGGCTATA
AAAGGGATCATCCAGTGGAGTTGTAAACAAGGGAACCATCTTGCAAGATCTAGGAAGAGGAAGGGGAGGGATGTGGACTGGGTCTGATCA
CAGCCCTTGGCCCTGCTTCATACTTTGGAGCTTATTAAGATCAATTTTGATAACCATGTAATTTCTTAGAACCATGGCAGGTAGTATTGT
GCTTTAAAAACCAGAGGCTCCTGAAAGTCGTTTACACCAGGTGGATTGATACCATGGCTGTAGCTGATGCAACTAACAAGTACTGGGGCC
AGTGATCACAATCCAGGTTGGAAACAGGAGTGAAGCCCACCAGCCTGCCTGGTTGATGGACAGCAGGCTCTGCCTTCTGGAGGCGGCTTA
TATCCCAACAGCCTGAGGCAGGGCTCTGTGGCCCAGGCCGGCAGTGGCTGCCTCTCTTGGTTCTGCATGGTACATTTTGCCAACCCTGAG
GACCAGTTCTTGGGGTTCCAGGCCTCGGCCTTCCTGCTCCACGTGCTCAAGCCCCCACAGGGGGCTGCGACACCATCTGGCTCCTCACAG
GGAGGTCCAGCCATGTTCTCTGGGCTCCCAGTGAGCCCCCTCCCCTCCGGCTACCCCCAGAATCCATCCTTCATTCCTCCACCAAGCTCC
TGTGTGAGCTGCAGCACCCACACGGGGGAAGCCCTGCACTCCAGCAGCATCTTCCAGCCTTGGCACAGAACTGATGGCAAAGGAAGGGCT
GGGTTTTCAGCTTCTGGGACCCGAGGAAGACCCCACCTCACTCCTCCTTCCCCAGTACATCAGACTGGTTAGGAGGCATCCCAGAAGGGG
CAGCCTCATGCCCAGGTTTCAGCCCTAAAGGTAATGATTGTCTTGACTCTGCCTTGGCATTTCGCTCGGAATCACGGCAGACTTGGAGTG
TTTCTTCAAGGCAGGCATCTGCTTATGAGCAAGGTCAAAGATTTTTCAAAATATTGTGCATTAATTCATTAAAGCTACTGTTAAATATTT
GCTGTTTTTAGATTGGCGTCCGTGCTAATTCTGCAGTTGTAGCACTGTATATTTTATCTCATTTCTGTGCCAAGAAAGTTCATCTTTATG
TTTTTCTAATACACAATCTTGATCTTGTTTCCAAAATAAAGCTTCAGCTCCTTGGTCAATAGAAGTAAGGGTGTAGCCATCCAGGGTCTC
CCGGCTCTAGGCAGACCGGATCCCGCAGTTCATCCCATGGTTGTTGAAATGTACCTCGATCAGTCATCTCTGGTATTCCTCACTCTAGCC
ATGAGCCATTGCCATCTTATGGGCCCGATTTGGGTACTCTGAATTATGTCATGGAGTAGACAGTTACTTCTAAATCCCAGCAACCAAGTT
GCGTATCCTTCCTTATAGCTAGTTTCTATAGAGAAGTGAAAAAGAAATCTGGCTTCCTTAATAAGATAGTTGAGCCTATGACATTAAGGA
GCAGCGCTGCTGGCGGAAGATTCTAGATTCACTGGTGGTTTAAGAGGCCCAGGGATTTAGTTCTTACTGGTGCGTAAGTGTTTTCCCATC
CTAACCGGAAAACCACTCACCCAGGCTTCCCCCACTTCCCCTCAAATTTTCTCAGCTCTGCCGCTGGTCTCCATGAACGGCAAGGGGAAC
CACCACTCATTCACTGTCAGTGTAGGTAAGACAGAGGATGCCCTTGCAAAAATTGGGACTGAGGACAGTAGCACACGGAATGGTGGATCG
TACATTTGCACCCAGAGCTACTAAACGCTCAGTGACCCCAGAGACCATTAATTTCCCGGAGTGAAGGGGATGGGGGTAGAGCTAATTGGA
ATTTTTATTATCCAGGACTCATCCTAAGAAGAATGTTGGCCTCTCTTCATCCCTGGCTTAGCCGTCAGGTAGAACGCTTACTCACCTGAC
ACCGACTTCTTAGAGAAGCGAGTCTTTTTTGAATGGAGGAGCGATGGTAACCCCACTAGGGGGCGCCCATGATCGGCTCCCAGTGCACCC
CCTTAAGGGTAAGCAGGCCACATATCTAGAGTCTGATAGTCTGTGTGTACATAAGGTCTAGAAGTCTGTGGAAACGCCCTGAAACCTGTA
GTATTATCTTAACTACCCTCTTATGTTAAGGTTTACATAATAGGATTTTTAAACAAATGTGTTTAATTTTTTAAGATCTCTTGTATTAAA
ATTTTCTTTTGGAATAAGCTGTGGAAATTTTGTTACAACCTGGTTGAGATCAACCTCTTTACAATGACACAAATTGTGACATTTTATAAA
TTAGATACTTCAGTGG

>4039_4039_1_ALG8-SNX29_ALG8_chr11_77835067_ENST00000299626_SNX29_chr16_12497305_ENST00000306030_length(amino acids)=284AA_BP=123
MAALTIATGTGNWFSALALGVTLLKCLLIPTYHSTDFEVHRNWLAITHSLPISQWYYEATSEWTLDYPPFFAWFEYILSHVAKYFDQEML
NVHNLNYSSSRTLLFQRFSVIFMDVLFVYAVRESNRALINVWIPSVFLRGKAANAFHVYQVYIRIKDDEWNIYRRYTEFRSLHHKLQNKY
PQVRAYNFPPKKAIGNKDAKFVEERRKQLQNYLRSVMNKVIQMVPEFAASPKKETLIQLMPFFVDITPPGEPVNSRPKAASRFPKLSRGQ
PRETRNVEPQSGDL

--------------------------------------------------------------
>4039_4039_2_ALG8-SNX29_ALG8_chr11_77835067_ENST00000299626_SNX29_chr16_12497305_ENST00000323433_length(transcript)=867nt_BP=440nt
AGAGGGCTTTCTCCGCATGCGCGGGATCCCGGATGTGGATCAAGTTGGTGGGAAGCGTGCGGTGCCGCAGCAATGGCGGCGCTCACAATT
GCCACGGGTACTGGCAATTGGTTTTCGGCTTTGGCGCTCGGGGTGACTCTTCTCAAATGCCTTCTCATCCCCACATACCATTCCACAGAT
TTTGAAGTACACCGAAACTGGCTTGCTATCACTCACAGTTTGCCAATATCACAGTGGTATTATGAGGCAACTTCAGAGTGGACGTTGGAT
TACCCCCCTTTCTTTGCATGGTTTGAGTATATCCTGTCACATGTTGCCAAATATTTTGATCAAGAAATGCTGAATGTCCATAATTTGAAT
TACTCCAGCTCAAGGACCTTACTTTTCCAGAGATTTTCCGTCATCTTTATGGATGTACTCTTTGTGTATGCTGTCCGTGAATCAAACCGG
GCGCTGATCAACGTCTGGATCCCCTCAGTGTTTCTCCGGGGCAAAGCAGCAAATGCATTCCACGTGTATCAGGTCTACATCCGGATAAAA
GACGATGAATGGAATATTTATCGCCGGTATACAGAGTTCAGGAGTTTGCACCACAAGTTACAAAACAAGTACCCTCAAGTGAGGGCCTAC
AACTTCCCACCCAAAAAGGCCATTGGAAACAAGGATGCCAAGTTTGTGGAGGAACGGAGAAAGCAGCTCCAGAATTACCTGCGCAGCGTC
ATGAACAAAGTCATCCAGATGGTCCCCGAGTTCGCTGCCAGCCCCAAGAAGGAGACCCTCATCCAGCTGATGCCCTTCTTCGTGGACTGG
ATCTCACTGTTTGGAAATGGCCGCGATAGTTCACGTGAGGAGTTCTCATCCTCTTAG

>4039_4039_2_ALG8-SNX29_ALG8_chr11_77835067_ENST00000299626_SNX29_chr16_12497305_ENST00000323433_length(amino acids)=264AA_BP=123
MAALTIATGTGNWFSALALGVTLLKCLLIPTYHSTDFEVHRNWLAITHSLPISQWYYEATSEWTLDYPPFFAWFEYILSHVAKYFDQEML
NVHNLNYSSSRTLLFQRFSVIFMDVLFVYAVRESNRALINVWIPSVFLRGKAANAFHVYQVYIRIKDDEWNIYRRYTEFRSLHHKLQNKY
PQVRAYNFPPKKAIGNKDAKFVEERRKQLQNYLRSVMNKVIQMVPEFAASPKKETLIQLMPFFVDWISLFGNGRDSSREEFSSS

--------------------------------------------------------------
>4039_4039_3_ALG8-SNX29_ALG8_chr11_77835067_ENST00000299626_SNX29_chr16_12497305_ENST00000566228_length(transcript)=6587nt_BP=440nt
AGAGGGCTTTCTCCGCATGCGCGGGATCCCGGATGTGGATCAAGTTGGTGGGAAGCGTGCGGTGCCGCAGCAATGGCGGCGCTCACAATT
GCCACGGGTACTGGCAATTGGTTTTCGGCTTTGGCGCTCGGGGTGACTCTTCTCAAATGCCTTCTCATCCCCACATACCATTCCACAGAT
TTTGAAGTACACCGAAACTGGCTTGCTATCACTCACAGTTTGCCAATATCACAGTGGTATTATGAGGCAACTTCAGAGTGGACGTTGGAT
TACCCCCCTTTCTTTGCATGGTTTGAGTATATCCTGTCACATGTTGCCAAATATTTTGATCAAGAAATGCTGAATGTCCATAATTTGAAT
TACTCCAGCTCAAGGACCTTACTTTTCCAGAGATTTTCCGTCATCTTTATGGATGTACTCTTTGTGTATGCTGTCCGTGAATCAAACCGG
GCGCTGATCAACGTCTGGATCCCCTCAGTGTTTCTCCGGGGCAAAGCAGCAAATGCATTCCACGTGTATCAGGTCTACATCCGGATAAAA
GACGATGAATGGAATATTTATCGCCGGTATACAGAGTTCAGGAGTTTGCACCACAAGTTACAAAACAAGTACCCTCAAGTGAGGGCCTAC
AACTTCCCACCCAAAAAGGCCATTGGAAACAAGGATGCCAAGTTTGTGGAGGAACGGAGAAAGCAGCTCCAGAATTACCTGCGCAGCGTC
ATGAACAAAGTCATCCAGATGGTCCCCGAGTTCGCTGCCAGCCCCAAGAAGGAGACCCTCATCCAGCTGATGCCCTTCTTCGTCGACATC
ACCCCGCCCGGAGAGCCTGTGAACAGCCGGCCCAAAGCAGCTTCCCGCTTCCCCAAACTGTCCCGGGGTCAGCCCCGGGAGACCCGCAAC
GTGGAGCCCCAGAGCGGTGACCTCTGACCTCGACAAAACCGCAGCCACGGGCCCTGTGCGTGGCACCAGCTGCGTCCACCCCAGCCACTG
CCGCTGGCCCCTCACCTCAGCGTGACAACCACGTCCACCTGGTGATCCTGAGAGCACACGATTCCCAACAGTTACACAACACCCCGATTA
AACTAATCAGTCTTCGAGCCGCATGATACCGTGACCCGAGAGACCAAGGCAGCACCTCGCTGGAGAGACTGGGACACACAGTCCTTCTGC
TTCTGGGGTCTACCCTGGGCTGCAAGGGCTGTTCCTCCACCTTTCTGTAGTTCAGGGCTGGCAGGAGGGTGGGCACCAGGTCAGGCTGGG
TGCGCCATGGTTGAGAGGCAAAGGTGATCCCCTATATAGGAAGGTTCATGCAGAGCCAGCCTCTCCACTCTTTCCCACGTGGGGACTAGA
ATGACTATTAGCCTCTCCTTTTGCTTTTTAAGGTTATTACCTGGCCTAACCTAGGGATGGCTGGCTTTGCGGGGGGGGGGGGGGGGGGGG
GCATGGTTCCTTTCACTGCATTTTCCACCAACAGTCATTAGACACCTGGCACTGTCACAGCTCACTTTTCCAGAGGGATATTCCTGTGGC
TTTGGCAAGGAGCCATTAGTGATGTGCAACTTGAGTTCAGAGAACTTCCCCTACCTCCCCCATGGCTGGCTTCAGGAAGGACCAGTGCCC
TCCATAGCCTGAGGCCACCTAGGCCCTCGCCAGGCTTGGAGTGGGGGGACTCAGACATCTGGCCCAGCCATCAGCAGCAACCTAGTAACC
CGGCGTCATCCAGCGTGTCCAAAGTAGCATTGGCCCTACAGTCATGAGAGACTTGGGTCAGGGAACCACTGCAGAAGGTTCCAGGGTTTT
CAAACCAGGCTCCATGACTATGAAGTTGGACCCAGTGTGGACACTTAACAGATCATGTGTCTCTCCACTAAAAACATTTTCCATCCCGTC
TGCCCCCGACATTGTCCTTGATAACAGAACTCTGCATCCCCTAAGACAGAGTCCTCTGTTCCTCCCATGTCAGGTGGCTCTCAGAGTACA
GGGACCTTGGCAGGTGGAGAGGAGGATGGGGACCAGCAGCTGGGCAGCCCCCAGGGCTCCTCCTCCAGTGAGCTCACATCAGAGCACCTC
ACAGAGCAATAGCCGTCCTCAGATGCTCAGCAAAGTTGTGGCAGTTTGCATTTCTAGGGTAAACTAACTAGGAAGGATGTCGTGAAATGG
ACTATGCAAGAGTAAGTTTGTGTGTTTCGCCTTAATCTGAGGCAGAGACACAGCAGAACCTGAGGAGAAAAGCAGGTGGAAGGTGACGGT
TAGATGGTAAGCCATGGGCTTGTCCTGGAACTGCTTCAACTCAGTGGCTTAAAATGAGAACTGCCCAGGTGAGCATGGAGCATCTCCTAG
GCTCGAGGACATCTCTGGAGAATCATCTGGAAGGTTTATACTGTGCCTTCCCCTCGTAGCAAAAAGGAAGATTGTTCATGGCCTTTAAGG
AAGGCTGAGATCACTCACACACAGCGCCCCCCCACCCCAGAGAAACCGAGTCAGCCTACATGACTTCCAAGGGGACCTGGGGCCAGATAA
GCCCTGCCCCGGTGAGACCAAATGAGCTGGAGCATGTATGGAGGTGCGGACCCTGCAGTCAGTTTGCGAGTGTGGAGGACCCGAGACATC
CTGTAAAGGCAACTTGGTCTCCCTCCCACTCACCTGCCAACATTGCTGCAATACACATGGTTTATCTGAAATTCCAAGGCCAGAGTGCAC
ATCAGCTCACATGACTGGCAACTCTAAATAGAGAGCCCTAATGGACTGAGGCAGGAAACGTCTAAAAGCTCAATCTGCTGTATGTCATGA
CCCCTTAGGTTGGGTTTATGCCACATCGGTCATTTTGAAGTAGGTGTTTGATGCCAGCTCAGAGACTGTCTCAGGAGTGCCTCCCTGGCC
TGGGTAGCTACCCTGGAGGTCATCTCCCTGTTCTCTGTTGGATAAAGGAACCTCCCCCATCTGTGACATTCCCTTGGGCCCAGGCTTATG
ACCTGCACCTTTTCTGACACCTGCCCCCAAAGCACAGGATGTGAATTGGTCTCTCTCCAGATACCCCACGAGGAAGCACCTTGGACATTC
TGCACATGATAATAATGCAACAGTCCCCCATTGCTGAGAGATACTAACCCGTGAGAAACAAGTATGCTCTCAGCTGGTATTGAACTGGTG
GGAGAAACTGCCTCCTACTTTTATAATACTGAATTATTCACAAAAAACCTGGTCTGCTCTCCAAAATGAGAGCATGTTCCTGGGAGCCAC
ATGGGGACCATCCCCAGCTGCCTGCTCCTGGTACCTCCCCCATGATCATGCACAGACCGTAGAGTCGAGTCATCTCGCAGATCCAGACCA
TCTCCTCTCATTCTCACTCTAAAAATGCTGGTGGCCCGCACATGACAGCAACTCCCCGAAGCCTTCCCTTTGGAATCCCATAGAATGTTC
TGCAATGATTGGGTCCATCTTGCTGCTCAGAAGAATCCCGTCCTGCTCTCTAGTGTGGTGGGATGAACTTCAGGCAACAAACAACTGGCA
GGGTTCCCAGTTCCTGGAGTTATGGAGCAGAAACACCCAGGCCTAGCAGAATTGTGGCTGAAACCTGGTGCCCAAATTCCACACCCTGGA
AATGTGTCAACTGCCTGTCAGCCTGGATTCAATTCTGAGGGCTAAGCCACGACCTTATCCATGAGTGGCGAAGACACCCCTGAGGAAAGG
ATTGCTTGCACCTCACATCTGTCTTCTTCTAAGATTACTCGGAGATTTTCAAACAACATCTGAGAACAGAAGCCCCCTCCCCTACTCAGA
GAGGAACGAGGGTGGCCCACCTCTCAAGGGCCTTGGATTCCTGGGACCACCCTTTGCTGGGAGGAAGAATCCACACCGAATCCTTCTGTC
TTCATGGCCTGCTGTGCTGAAACAGAACAGCAGGTTCCATCTTTCACATCTTTTTTTCTCCCCCAGATGAAAGACGACTCAGGAACGGTA
GGGCTGGGCAGAGGTGTCTCTCCTTGAGAGACAACAAAAGCTTCTAAGGGAGGGAGCTTAAAGGCTGCTAGAAACCTAGCCCAACCATCC
ACTCCTGATCTGAGACAGAACCTTCTCCGCCACTCTTCCTGCAATCAGTGTGAAATTCCAGCTTCTTTGATTCCCACTTAGCAGTATGCT
CCAATCACGTTGCTGGCAAGGCATTTTAGAGTTTGGAGCTGAGGTTCAAAGCCCCCTGCATTTCTCTACTGGCAGGCCCTGGTGAAGGAA
GACACTTTCAGGGAAGAGGCTCTTACAGTCTATGGTGGTAGCCATCTTCACATCCAGTCACCAGTTGCATCTAGGGAGCTGCTGGCTATA
AAAGGGATCATCCAGTGGAGTTGTAAACAAGGGAACCATCTTGCAAGATCTAGGAAGAGGAAGGGGAGGGATGTGGACTGGGTCTGATCA
CAGCCCTTGGCCCTGCTTCATACTTTGGAGCTTATTAAGATCAATTTTGATAACCATGTAATTTCTTAGAACCATGGCAGGTAGTATTGT
GCTTTAAAAACCAGAGGCTCCTGAAAGTCGTTTACACCAGGTGGATTGATACCATGGCTGTAGCTGATGCAACTAACAAGTACTGGGGCC
AGTGATCACAATCCAGGTTGGAAACAGGAGTGAAGCCCACCAGCCTGCCTGGTTGATGGACAGCAGGCTCTGCCTTCTGGAGGCGGCTTA
TATCCCAACAGCCTGAGGCAGGGCTCTGTGGCCCAGGCCGGCAGTGGCTGCCTCTCTTGGTTCTGCATGGTACATTTTGCCAACCCTGAG
GACCAGTTCTTGGGGTTCCAGGCCTCGGCCTTCCTGCTCCACGTGCTCAAGCCCCCACAGGGGGCTGCGACACCATCTGGCTCCTCACAG
GGAGGTCCAGCCATGTTCTCTGGGCTCCCAGTGAGCCCCCTCCCCTCCGGCTACCCCCAGAATCCATCCTTCATTCCTCCACCAAGCTCC
TGTGTGAGCTGCAGCACCCACACGGGGGAAGCCCTGCACTCCAGCAGCATCTTCCAGCCTTGGCACAGAACTGATGGCAAAGGAAGGGCT
GGGTTTTCAGCTTCTGGGACCCGAGGAAGACCCCACCTCACTCCTCCTTCCCCAGTACATCAGACTGGTTAGGAGGCATCCCAGAAGGGG
CAGCCTCATGCCCAGGTTTCAGCCCTAAAGGTAATGATTGTCTTGACTCTGCCTTGGCATTTCGCTCGGAATCACGGCAGACTTGGAGTG
TTTCTTCAAGGCAGGCATCTGCTTATGAGCAAGGTCAAAGATTTTTCAAAATATTGTGCATTAATTCATTAAAGCTACTGTTAAATATTT
GCTGTTTTTAGATTGGCGTCCGTGCTAATTCTGCAGTTGTAGCACTGTATATTTTATCTCATTTCTGTGCCAAGAAAGTTCATCTTTATG
TTTTTCTAATACACAATCTTGATCTTGTTTCCAAAATAAAGCTTCAGCTCCTTGGTCAATAGAAGTAAGGGTGTAGCCATCCAGGGTCTC
CCGGCTCTAGGCAGACCGGATCCCGCAGTTCATCCCATGGTTGTTGAAATGTACCTCGATCAGTCATCTCTGGTATTCCTCACTCTAGCC
ATGAGCCATTGCCATCTTATGGGCCCGATTTGGGTACTCTGAATTATGTCATGGAGTAGACAGTTACTTCTAAATCCCAGCAACCAAGTT
GCGTATCCTTCCTTATAGCTAGTTTCTATAGAGAAGTGAAAAAGAAATCTGGCTTCCTTAATAAGATAGTTGAGCCTATGACATTAAGGA
GCAGCGCTGCTGGCGGAAGATTCTAGATTCACTGGTGGTTTAAGAGGCCCAGGGATTTAGTTCTTACTGGTGCGTAAGTGTTTTCCCATC
CTAACCGGAAAACCACTCACCCAGGCTTCCCCCACTTCCCCTCAAATTTTCTCAGCTCTGCCGCTGGTCTCCATGAACGGCAAGGGGAAC
CACCACTCATTCACTGTCAGTGTAGGTAAGACAGAGGATGCCCTTGCAAAAATTGGGACTGAGGACAGTAGCACACGGAATGGTGGATCG
TACATTTGCACCCAGAGCTACTAAACGCTCAGTGACCCCAGAGACCATTAATTTCCCGGAGTGAAGGGGATGGGGGTAGAGCTAATTGGA
ATTTTTATTATCCAGGACTCATCCTAAGAAGAATGTTGGCCTCTCTTCATCCCTGGCTTAGCCGTCAGGTAGAACGCTTACTCACCTGAC
ACCGACTTCTTAGAGAAGCGAGTCTTTTTTGAATGGAGGAGCGATGGTAACCCCACTAGGGGGCGCCCATGATCGGCTCCCAGTGCACCC
CCTTAAGGGTAAGCAGGCCACATATCTAGAGTCTGATAGTCTGTGTGTACATAAGGTCTAGAAGTCTGTGGAAACGCCCTGAAACCTGTA
GTATTATCTTAACTACCCTCTTATGTTAAGGTTTACATAATAGGATTTTTAAACAAATGTGTTTAATTTTTTAAGATCTCTTGTATTAAA
ATTTTCTTTTGGAATAAGCTGTGGAAATTTTGTTACAACCTGGTTGAGATCAACCTCTTTACAATGACACAAATTGTGACATTTTATAAA
TTAGATACTTCAGTGGA

>4039_4039_3_ALG8-SNX29_ALG8_chr11_77835067_ENST00000299626_SNX29_chr16_12497305_ENST00000566228_length(amino acids)=284AA_BP=123
MAALTIATGTGNWFSALALGVTLLKCLLIPTYHSTDFEVHRNWLAITHSLPISQWYYEATSEWTLDYPPFFAWFEYILSHVAKYFDQEML
NVHNLNYSSSRTLLFQRFSVIFMDVLFVYAVRESNRALINVWIPSVFLRGKAANAFHVYQVYIRIKDDEWNIYRRYTEFRSLHHKLQNKY
PQVRAYNFPPKKAIGNKDAKFVEERRKQLQNYLRSVMNKVIQMVPEFAASPKKETLIQLMPFFVDITPPGEPVNSRPKAASRFPKLSRGQ
PRETRNVEPQSGDL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ALG8-SNX29


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ALG8-SNX29


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ALG8-SNX29


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneALG8C2931002Congenital disorder of glycosylation type 1H4CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneALG8C0011581Depressive disorder1PSYGENET
HgeneALG8C0158683Polycystic liver disease1GENOMICS_ENGLAND
HgeneALG8C1691228Cystic Kidney Diseases1GENOMICS_ENGLAND
HgeneALG8C4551631Cystic liver disease1GENOMICS_ENGLAND
HgeneALG8C4693472POLYCYSTIC LIVER DISEASE 3 WITH OR WITHOUT KIDNEY CYSTS1GENOMICS_ENGLAND