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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:APOO-CNKSR2 (FusionGDB2 ID:HG79135TG22866)

Fusion Gene Summary for APOO-CNKSR2

check button Fusion gene summary
Fusion gene informationFusion gene name: APOO-CNKSR2
Fusion gene ID: hg79135tg22866
HgeneTgene
Gene symbol

APOO

CNKSR2

Gene ID

79135

22866

Gene nameapolipoprotein Oconnector enhancer of kinase suppressor of Ras 2
SynonymsFAM121B|MIC26|MICOS26|Mic23|My025CNK2|KSR2|MAGUIN|MRXSHG
Cytomap('APOO')('CNKSR2')

Xp22.11

Xp22.12

Type of geneprotein-codingprotein-coding
DescriptionMICOS complex subunit MIC26MICOS complex subunit MIC23brain my025family with sequence similarity 121Bmitochondrial contact site and cristae organizing system subunit 26connector enhancer of kinase suppressor of ras 2CNK homolog protein 2connector enhancer of KSR2membrane-associated guanylate kinase-interacting protein
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000379220, ENST00000379226, 
ENST00000476598, 
Fusion gene scores* DoF score9 X 10 X 4=3606 X 9 X 4=216
# samples 107
** MAII scorelog2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/216*10)=-1.6256044852185
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: APOO [Title/Abstract] AND CNKSR2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAPOO(23897032)-CNKSR2(21488884), # samples:2
Anticipated loss of major functional domain due to fusion event.APOO-CNKSR2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
APOO-CNKSR2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
APOO-CNKSR2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
APOO-CNKSR2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCNKSR2

GO:0035556

intracellular signal transduction

14597674


check buttonFusion gene breakpoints across APOO (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CNKSR2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-66-2790-01AAPOOchrX

23897032

-CNKSR2chrX

21488884

+
ChimerDB4LUSCTCGA-66-2790APOOchrX

23897032

-CNKSR2chrX

21488884

+


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Fusion Gene ORF analysis for APOO-CNKSR2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000379220ENST00000485012APOOchrX

23897032

-CNKSR2chrX

21488884

+
5CDS-intronENST00000379226ENST00000485012APOOchrX

23897032

-CNKSR2chrX

21488884

+
In-frameENST00000379220ENST00000279451APOOchrX

23897032

-CNKSR2chrX

21488884

+
In-frameENST00000379220ENST00000379510APOOchrX

23897032

-CNKSR2chrX

21488884

+
In-frameENST00000379220ENST00000425654APOOchrX

23897032

-CNKSR2chrX

21488884

+
In-frameENST00000379220ENST00000543067APOOchrX

23897032

-CNKSR2chrX

21488884

+
In-frameENST00000379226ENST00000279451APOOchrX

23897032

-CNKSR2chrX

21488884

+
In-frameENST00000379226ENST00000379510APOOchrX

23897032

-CNKSR2chrX

21488884

+
In-frameENST00000379226ENST00000425654APOOchrX

23897032

-CNKSR2chrX

21488884

+
In-frameENST00000379226ENST00000543067APOOchrX

23897032

-CNKSR2chrX

21488884

+
intron-3CDSENST00000476598ENST00000279451APOOchrX

23897032

-CNKSR2chrX

21488884

+
intron-3CDSENST00000476598ENST00000379510APOOchrX

23897032

-CNKSR2chrX

21488884

+
intron-3CDSENST00000476598ENST00000425654APOOchrX

23897032

-CNKSR2chrX

21488884

+
intron-3CDSENST00000476598ENST00000543067APOOchrX

23897032

-CNKSR2chrX

21488884

+
intron-intronENST00000476598ENST00000485012APOOchrX

23897032

-CNKSR2chrX

21488884

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000379226APOOchrX23897032-ENST00000543067CNKSR2chrX21488884+38254692322499755
ENST00000379226APOOchrX23897032-ENST00000425654CNKSR2chrX21488884+51384692322964910
ENST00000379226APOOchrX23897032-ENST00000279451CNKSR2chrX21488884+39724692322646804
ENST00000379226APOOchrX23897032-ENST00000379510CNKSR2chrX21488884+52294692323054940
ENST00000379220APOOchrX23897032-ENST00000543067CNKSR2chrX21488884+38314752382505755
ENST00000379220APOOchrX23897032-ENST00000425654CNKSR2chrX21488884+51444752382970910
ENST00000379220APOOchrX23897032-ENST00000279451CNKSR2chrX21488884+39784752382652804
ENST00000379220APOOchrX23897032-ENST00000379510CNKSR2chrX21488884+52354752383060940

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000379226ENST00000543067APOOchrX23897032-CNKSR2chrX21488884+0.0004217350.9995783
ENST00000379226ENST00000425654APOOchrX23897032-CNKSR2chrX21488884+0.000112260.9998877
ENST00000379226ENST00000279451APOOchrX23897032-CNKSR2chrX21488884+0.0003490890.99965096
ENST00000379226ENST00000379510APOOchrX23897032-CNKSR2chrX21488884+0.0001345120.9998654
ENST00000379220ENST00000543067APOOchrX23897032-CNKSR2chrX21488884+0.0004233350.9995766
ENST00000379220ENST00000425654APOOchrX23897032-CNKSR2chrX21488884+0.0001124910.99988747
ENST00000379220ENST00000279451APOOchrX23897032-CNKSR2chrX21488884+0.000349980.99965
ENST00000379220ENST00000379510APOOchrX23897032-CNKSR2chrX21488884+0.000134880.99986506

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Fusion Genomic Features for APOO-CNKSR2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
APOOchrX23897031-CNKSR2chrX21488883+0.0001089030.99989104
APOOchrX23897031-CNKSR2chrX21488883+0.0001089030.99989104
APOOchrX23897031-CNKSR2chrX21488883+0.0001089030.99989104
APOOchrX23897031-CNKSR2chrX21488883+0.0001089030.99989104

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for APOO-CNKSR2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:23897032/chrX:21488884)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCNKSR2chrX:23897032chrX:21488884ENST00000279451321875_904173899.0Coiled coilOntology_term=ECO:0000255
TgeneCNKSR2chrX:23897032chrX:21488884ENST00000379510322875_9041731035.0Coiled coilOntology_term=ECO:0000255
TgeneCNKSR2chrX:23897032chrX:21488884ENST00000425654321875_9041731005.0Coiled coilOntology_term=ECO:0000255
TgeneCNKSR2chrX:23897032chrX:21488884ENST00000543067320875_904173850.0Coiled coilOntology_term=ECO:0000255
TgeneCNKSR2chrX:23897032chrX:21488884ENST00000279451321354_357173899.0Compositional biasNote=Poly-Pro
TgeneCNKSR2chrX:23897032chrX:21488884ENST00000279451321703_706173899.0Compositional biasNote=Poly-Pro
TgeneCNKSR2chrX:23897032chrX:21488884ENST00000279451321875_888173899.0Compositional biasNote=Poly-Glu
TgeneCNKSR2chrX:23897032chrX:21488884ENST00000379510322354_3571731035.0Compositional biasNote=Poly-Pro
TgeneCNKSR2chrX:23897032chrX:21488884ENST00000379510322703_7061731035.0Compositional biasNote=Poly-Pro
TgeneCNKSR2chrX:23897032chrX:21488884ENST00000379510322875_8881731035.0Compositional biasNote=Poly-Glu
TgeneCNKSR2chrX:23897032chrX:21488884ENST00000425654321354_3571731005.0Compositional biasNote=Poly-Pro
TgeneCNKSR2chrX:23897032chrX:21488884ENST00000425654321703_7061731005.0Compositional biasNote=Poly-Pro
TgeneCNKSR2chrX:23897032chrX:21488884ENST00000425654321875_8881731005.0Compositional biasNote=Poly-Glu
TgeneCNKSR2chrX:23897032chrX:21488884ENST00000543067320354_357173850.0Compositional biasNote=Poly-Pro
TgeneCNKSR2chrX:23897032chrX:21488884ENST00000543067320703_706173850.0Compositional biasNote=Poly-Pro
TgeneCNKSR2chrX:23897032chrX:21488884ENST00000543067320875_888173850.0Compositional biasNote=Poly-Glu
TgeneCNKSR2chrX:23897032chrX:21488884ENST00000279451321215_297173899.0DomainPDZ
TgeneCNKSR2chrX:23897032chrX:21488884ENST00000279451321332_515173899.0DomainNote=DUF1170
TgeneCNKSR2chrX:23897032chrX:21488884ENST00000279451321570_669173899.0DomainPH
TgeneCNKSR2chrX:23897032chrX:21488884ENST00000379510322215_2971731035.0DomainPDZ
TgeneCNKSR2chrX:23897032chrX:21488884ENST00000379510322332_5151731035.0DomainNote=DUF1170
TgeneCNKSR2chrX:23897032chrX:21488884ENST00000379510322570_6691731035.0DomainPH
TgeneCNKSR2chrX:23897032chrX:21488884ENST00000425654321215_2971731005.0DomainPDZ
TgeneCNKSR2chrX:23897032chrX:21488884ENST00000425654321332_5151731005.0DomainNote=DUF1170
TgeneCNKSR2chrX:23897032chrX:21488884ENST00000425654321570_6691731005.0DomainPH
TgeneCNKSR2chrX:23897032chrX:21488884ENST00000543067320215_297173850.0DomainPDZ
TgeneCNKSR2chrX:23897032chrX:21488884ENST00000543067320332_515173850.0DomainNote=DUF1170
TgeneCNKSR2chrX:23897032chrX:21488884ENST00000543067320570_669173850.0DomainPH

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAPOOchrX:23897032chrX:21488884ENST00000379226-39108_12879191.0TransmembraneHelical
TgeneCNKSR2chrX:23897032chrX:21488884ENST0000027945132111_76173899.0DomainSAM
TgeneCNKSR2chrX:23897032chrX:21488884ENST0000027945132184_178173899.0DomainCRIC
TgeneCNKSR2chrX:23897032chrX:21488884ENST0000037951032211_761731035.0DomainSAM
TgeneCNKSR2chrX:23897032chrX:21488884ENST0000037951032284_1781731035.0DomainCRIC
TgeneCNKSR2chrX:23897032chrX:21488884ENST0000042565432111_761731005.0DomainSAM
TgeneCNKSR2chrX:23897032chrX:21488884ENST0000042565432184_1781731005.0DomainCRIC
TgeneCNKSR2chrX:23897032chrX:21488884ENST0000054306732011_76173850.0DomainSAM
TgeneCNKSR2chrX:23897032chrX:21488884ENST0000054306732084_178173850.0DomainCRIC


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Fusion Gene Sequence for APOO-CNKSR2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5632_5632_1_APOO-CNKSR2_APOO_chrX_23897032_ENST00000379220_CNKSR2_chrX_21488884_ENST00000279451_length(transcript)=3978nt_BP=475nt
GGGTTTGCGTTCACCCGCTGCCCGGGCGCGACGCGCTGCGGCTCAGCGACGCGGCTTCTAGAACCGGGTGATTGAACTAAACCTTCGCCG
CACCGAGTTTGCAGTACGGCCGTCACCCGCACCGCTGCCTGCTTGCGGTTGGAGAAATCAAGGCCCTACCGGGCCTCCGTAGTCACCTCT
CTATAGTGGGCGTGGCCGAGGCCGGGGTGACCCTGCCGGAGCCTCCGCTGCCAGCGACATGTTCAAGGTAATTCAGAGGTCCGTGGGGCC
AGCCAGCCTGAGCTTGCTCACCTTCAAAGTCTATGCAGCACCAAAAAAGGACTCACCTCCCAAAAATTCCGTGAAGGTTGATGAGCTTTC
ACTCTACTCAGTTCCTGAGGGTCAATCGAAGTATGTGGAGGAGGCAAGGAGCCAGCTTGAAGAAAGCATCTCACAGCTCCGACACTATTG
CGAGCCATACACAACCTGGTGTCAGGATTGTACTGTATATGAAACAGAGAATAAAATTCTTCACGTGTGTAAAACTCTTTCTGGAGTCTG
TGACCACATCATATCCCTGTCGTCAGATCCTCTGGTTTCACAGTCTGCTCACCTGGAAGTGATTCAACTGGCAAACATTAAACCAAGCGA
AGGGCTGGGTATGTATATTAAATCTACATATGATGGCCTCCATGTAATTACTGGAACCACAGAAAATTCACCTGCAGATCGGTGCAAGAA
AATCCATGCTGGCGATGAAGTGATTCAAGTTAATCATCAGACTGTGGTGGGGTGGCAGTTGAAAAATTTGGTGAATGCACTACGAGAGGA
CCCGAGTGGTGTTATCTTAACTTTGAAAAAGCGACCTCAGAGCATGCTTACCTCAGCACCAGCTTTACTGAAAAATATGAGATGGAAGCC
CCTTGCTCTGCAGCCTCTTATACCTAGAAGTCCCACAAGCAGCGTTGCCACGCCTTCCAGCACCATCAGTACACCCACCAAAAGAGACAG
TTCTGCCCTCCAGGATCTCTACATTCCCCCTCCTCCTGCAGAACCATATATTCCCAGGGATGAAAAAGGAAACCTTCCTTGTGAAGACCT
CAGAGGACATATGGTGGGCAAGCCAGTGCATAAGGGATCTGAATCACCAAATTCATTTCTGGATCAGGAATATCGAAAGAGATTTAATAT
TGTCGAAGAAGATACTGTCTTATATTGCTATGAATATGAAAAAGGAAGATCAAGTAGTCAAGGAAGACGAGAAAGCACCCCAACTTATGG
CAAGCTACGACCTATATCTATGCCAGTGGAATATAATTGGGTGGGGGACTATGAAGATCCAAATAAGATGAAGAGAGATAGTAGAAGAGA
AAACTCTCTACTTCGGTATATGAGCAATGAAAAGATTGCTCAAGAAGAATACATGTTTCAGAGAAACAGCAAAAAGGACACAGGGAAGAA
GTCAAAAAAGAAGGGTGATAAGAGTAATAGCCCAACTCACTATTCATTGCTACCTAGTTTACAAATGGATGCACTGAGACAAGACATCAT
GGGCACTCCTGTGCCAGAGACCACACTATACCATACATTTCAGCAGTCCTCACTGCAGCACAAATCAAAGAAGAAAAACAAAGGTCCTAT
AGCAGGCAAGAGCAAAAGACGAATTTCTTGCAAAGATCTTGGCCGTGGTGACTGTGAGGGCTGGCTTTGGAAAAAGAAAGATGCGAAGAG
TTACTTTTCACAGAAATGGAAAAAATATTGGTTTGTCCTAAAGGATGCATCCCTTTATTGGTATATTAATGAGGAGGATGAAAAAGCAGA
AGGATTCATTAGCCTGCCTGAATTTAAAATTGATAGAGCCAGTGAATGCCGCAAAAAATATGCATTCAAAGCCTGTCATCCTAAAATCAA
AAGCTTTTATTTTGCTGCTGAACATCTTGATGATATGAACAGGTGGCTTAACAGAATTAATATGCTGACTGCAGGATATGCAGAAAGAGA
GAGGATTAAGCAGGAACAAGATTACTGGAGTGAGAGTGACAAGGAAGAAGCAGATACTCCATCAACACCAAAACAAGATAGCCCTCCACC
CCCATATGATACATACCCACGACCTCCCTCGATGAGTTGCGCCAGTCCTTATGTGGAAGCAAAACATAGCCGACTTTCCTCCACGGAGAC
TTCTCAGTCTCAGTCTTCTCATGAGGAGTTTCGCCAGGAAGTAACTGGGAGCAGTGCAGTGTCTCCCATTCGCAAGACAGCCAGTCAGCG
CCGCTCCTGGCAGGATTTAATTGAGACGCCACTGACAAGTTCAGGCTTACACTATCTTCAGACTCTGCCCCTGGAGGATTCTGTCTTCTC
TGACTCCGCGGCCATCTCCCCAGAGCACAGGCGGCAGTCTACCCTGCCAACTCAGAAATGCCACCTGCAGGATCACTATGGGCCATACCC
CTTAGCTGAGAGTGAGAGGATGCAAGTGCTAAATGGAAATGGGGGCAAGCCTCGAAGTTTTACTCTGCCTCGAGATAGCGGGTTCAACCA
TTGCTGTCTGAATGCTCCAGTTAGTGCCTGTGACCCACAGGATGACGTGCAACCCCCAGAGGTGGAGGAAGAGGAGGAGGAGGAGGAGGA
GGAAGGGGAGGCAGCAGGGGAAAACATAGGAGAAAAAAGCTAATACACTGCGAGAGTTGGTAGAACCTCTCCATGCCAAATCGGATCCAC
TTCTGTTGGCACTCAACCCATTGGACTCACAGATTGATAAGCTAATGTTTAGAGAATTTAGATCGGAGAGAGTCGGTACGGCGCAGACTC
AACATCAACCTCTTGCAAGCAACTAAAATGGCCTCGTCCTTGCTGTTTATAACAGAAAACAGACTTGTAAAAAGCTTAGATCATCAAGTG
TTTTGGATTGGGGGCCTCCCAAAGGGATATAAGAGGGGCAGGCCACTCTTAAGAAGAATGCGAGCTTTCTACATTGGGACTAGCATAAGA
TCAAAGCCAATCAAGATGGAGCACAGTAACAGAAAACTGCGGTTTCTGTGGGAGAACAGAAGGGGAAAGGGTCTTAACTGGGAAAGGGCT
CTGTGTGGTAACACCTCAGTTGTGTTCTCCTGACACCAGGAAAAGAGAGGGATCAGCTTCAATAACTAGAAAATTCTGGCTGTTTAATGG
ACTCTTTGGTGGCCTCTTTAAGGCAAAGCAGAGAAAGCAAATTATGTATTAAGTGTATTTTGCATTTTTAAAACTTGACGTGCTGTATTG
TACTAAATTAAGTGTAATCTATTAAGGCAAGGTATACACAATTTGCTTTGAAACTTACTATGTTTATTCTATTATAAAGTGTATTCAGGT
GCAACACAGAGACTGCTTTCGGTGACATTAATGAAGAAAATTTCTCATGCCAGGCTTTATTATAGAATCTTCAGCTAAAATCCTAACTTT
CTCCTTATTTCTTGGCACTTGTATACAAGTGGTGTTGCCTCTTAGGGCAGGCATGAGCTATTCTTTTCTGTAAAATATTTTGAATCTATA
GGCTGTGGGTTTCATTTTTGAAAAGTATTTTGTCTGGATGTCTTTCAAACTAGCTTCAGATATTATTTAATACTATGTAACTGGGTCCCC
TATGGCTCAATCAATATTGCTTATTTTTCTTCTGTAGTGGATGTGAAATTTCCTTTAGTTGGATAAGATACACTGTAATAATTTTAATGC
TAATTAATGATATTTCATACTGTGCAATGAACAGATAATTTAACACTGTATTTTGAAATGTTTTTTTCTTCCTGTCACCGCAGTGTGTGG
TATTGCATAATGTGAATACCTGTAAAAATATAAATTACTTAAAAATAAAAATATGACCAATTGGTATCAGATCTTTTCAGATAGCTAAAT
AATTTGCTAAGTATGCCTGATAGTAAATATCTTTCTAAAAAGAAGTAATCAGTGCTTCTTTCTCACAAATGGAATTTGTGTCTGTGAATA

>5632_5632_1_APOO-CNKSR2_APOO_chrX_23897032_ENST00000379220_CNKSR2_chrX_21488884_ENST00000279451_length(amino acids)=804AA_BP=78
MFKVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQDCTVYETENKI
LHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQ
LKNLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPR
DEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYED
PNKMKRDSRRENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKSNSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQ
HKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKK
YAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVE
AKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQK

--------------------------------------------------------------
>5632_5632_2_APOO-CNKSR2_APOO_chrX_23897032_ENST00000379220_CNKSR2_chrX_21488884_ENST00000379510_length(transcript)=5235nt_BP=475nt
GGGTTTGCGTTCACCCGCTGCCCGGGCGCGACGCGCTGCGGCTCAGCGACGCGGCTTCTAGAACCGGGTGATTGAACTAAACCTTCGCCG
CACCGAGTTTGCAGTACGGCCGTCACCCGCACCGCTGCCTGCTTGCGGTTGGAGAAATCAAGGCCCTACCGGGCCTCCGTAGTCACCTCT
CTATAGTGGGCGTGGCCGAGGCCGGGGTGACCCTGCCGGAGCCTCCGCTGCCAGCGACATGTTCAAGGTAATTCAGAGGTCCGTGGGGCC
AGCCAGCCTGAGCTTGCTCACCTTCAAAGTCTATGCAGCACCAAAAAAGGACTCACCTCCCAAAAATTCCGTGAAGGTTGATGAGCTTTC
ACTCTACTCAGTTCCTGAGGGTCAATCGAAGTATGTGGAGGAGGCAAGGAGCCAGCTTGAAGAAAGCATCTCACAGCTCCGACACTATTG
CGAGCCATACACAACCTGGTGTCAGGATTGTACTGTATATGAAACAGAGAATAAAATTCTTCACGTGTGTAAAACTCTTTCTGGAGTCTG
TGACCACATCATATCCCTGTCGTCAGATCCTCTGGTTTCACAGTCTGCTCACCTGGAAGTGATTCAACTGGCAAACATTAAACCAAGCGA
AGGGCTGGGTATGTATATTAAATCTACATATGATGGCCTCCATGTAATTACTGGAACCACAGAAAATTCACCTGCAGATCGGTGCAAGAA
AATCCATGCTGGCGATGAAGTGATTCAAGTTAATCATCAGACTGTGGTGGGGTGGCAGTTGAAAAATTTGGTGAATGCACTACGAGAGGA
CCCGAGTGGTGTTATCTTAACTTTGAAAAAGCGACCTCAGAGCATGCTTACCTCAGCACCAGCTTTACTGAAAAATATGAGATGGAAGCC
CCTTGCTCTGCAGCCTCTTATACCTAGAAGTCCCACAAGCAGCGTTGCCACGCCTTCCAGCACCATCAGTACACCCACCAAAAGAGACAG
TTCTGCCCTCCAGGATCTCTACATTCCCCCTCCTCCTGCAGAACCATATATTCCCAGGGATGAAAAAGGAAACCTTCCTTGTGAAGACCT
CAGAGGACATATGGTGGGCAAGCCAGTGCATAAGGGATCTGAATCACCAAATTCATTTCTGGATCAGGAATATCGAAAGAGATTTAATAT
TGTCGAAGAAGATACTGTCTTATATTGCTATGAATATGAAAAAGGAAGATCAAGTAGTCAAGGAAGACGAGAAAGCACCCCAACTTATGG
CAAGCTACGACCTATATCTATGCCAGTGGAATATAATTGGGTGGGGGACTATGAAGATCCAAATAAGATGAAGAGAGATAGTAGAAGAGA
AAACTCTCTACTTCGGTATATGAGCAATGAAAAGATTGCTCAAGAAGAATACATGTTTCAGAGAAACAGCAAAAAGGACACAGGGAAGAA
GTCAAAAAAGAAGGGTGATAAGAGTAATAGCCCAACTCACTATTCATTGCTACCTAGTTTACAAATGGATGCACTGAGACAAGACATCAT
GGGCACTCCTGTGCCAGAGACCACACTATACCATACATTTCAGCAGTCCTCACTGCAGCACAAATCAAAGAAGAAAAACAAAGGTCCTAT
AGCAGGCAAGAGCAAAAGACGAATTTCTTGCAAAGATCTTGGCCGTGGTGACTGTGAGGGCTGGCTTTGGAAAAAGAAAGATGCGAAGAG
TTACTTTTCACAGAAATGGAAAAAATATTGGTTTGTCCTAAAGGATGCATCCCTTTATTGGTATATTAATGAGGAGGATGAAAAAGCAGA
AGGATTCATTAGCCTGCCTGAATTTAAAATTGATAGAGCCAGTGAATGCCGCAAAAAATATGCATTCAAAGCCTGTCATCCTAAAATCAA
AAGCTTTTATTTTGCTGCTGAACATCTTGATGATATGAACAGGTGGCTTAACAGAATTAATATGCTGACTGCAGGATATGCAGAAAGAGA
GAGGATTAAGCAGGAACAAGATTACTGGAGTGAGAGTGACAAGGAAGAAGCAGATACTCCATCAACACCAAAACAAGATAGCCCTCCACC
CCCATATGATACATACCCACGACCTCCCTCGATGAGTTGCGCCAGTCCTTATGTGGAAGCAAAACATAGCCGACTTTCCTCCACGGAGAC
TTCTCAGTCTCAGTCTTCTCATGAGGAGTTTCGCCAGGAAGTAACTGGGAGCAGTGCAGTGTCTCCCATTCGCAAGACAGCCAGTCAGCG
CCGCTCCTGGCAGGATTTAATTGAGACGCCACTGACAAGTTCAGGCTTACACTATCTTCAGACTCTGCCCCTGGAGGATTCTGTCTTCTC
TGACTCCGCGGCCATCTCCCCAGAGCACAGGCGGCAGTCTACCCTGCCAACTCAGAAATGCCACCTGCAGGATCACTATGGGCCATACCC
CTTAGCTGAGAGTGAGAGGATGCAAGTGCTAAATGGAAATGGGGGCAAGCCTCGAAGTTTTACTCTGCCTCGAGATAGCGGGTTCAACCA
TTGCTGTCTGAATGCTCCAGTTAGTGCCTGTGACCCACAGGATGACGTGCAACCCCCAGAGGTGGAGGAAGAGGAGGAGGAGGAGGAGGA
GGAAGGGGAGGCAGCAGGGGAAAACATAGGAGAAAAAAGTGAAAGCAGAGAAGAAAAGTTAGGAGACTCATTGCAAGATTTATACAGGGC
ACTGGAGCAGGCCAGTCTGTCACCACTAGGAGAACATCGTATTTCAACCAAGATGGAATACAAGCTATCATTTATAAAAAGATGTAATGA
TCCTGTAATGAATGAAAAACTACACCGGCTGAGAATTCTCAAAAGCACTTTAAAGGCCAGAGAAGGGGAAGTAGCCATTATCGATAAAGT
CCTAGACAATCCAGACTTGACATCTAAAGAATTCCAACAATGGAAGCAGATGTACCTCGACCTTTTCTTGGATATCTGTCAAAATACCAC
CTCAAATGACCCACTGAGTATTTCTTCTGAAGTAGATGTAATCACTTCCTCTCTAGCACACACTCATTCATACATTGAAACGCATGTCTA
AATGTATTCTGCCTTCAGACCATCTAGTACCTGCTGGTACTCTGAACAAGTATATAAGGTAGTTTTTATATCAATGTGTGGAACACTTGA
CAAGCTATACTTTAATGTTACCAAACTATATGAAACAAACCATATATGGTCACAATACCACTATCTTTAATGAGCATTTGTATATTTTAT
ATGCAACAGTGCTCAGCTTATGTTTACCATGTGCAAAATCAACTGTCTTTAATGACTTAAAATTAACTTTTGCAAACAATTCTAAATACA
GGTGGTCTTCAAGTAGTAAAACCACAAAAGGCAGTTTTCTATCTATGGTCATCTTTTCTCCCTTTAAGTTAATTTTATATAAACAAGACT
TCAAAAGTAAATCACATTTTTTCAGGTGCAGACATCCTTGTGGGTGGGAAAGAATTTAAACCTTTTTTATATTTATTAAAATGTTCTAAG
AATTTTCTTAAACATTGCACAAAGTTTAATGCTGTAGTTTTATTTTTGTGAAATGTAGATGCGCATACAAGAGCTAAGCAAAATAGAAGA
GCATCGACATAAGAAAAGTTCAGGTATCTAATATTCGTCTTAATAGTCTATTAACTTGTGAAAGCTAAGTTAATGGAAATATTATTCCAA
ATCTATGAGAACACTTGGTGTATCAGGGCAAAGCTTTGTAAGATGTTTTTGTAACTAAGACCAAAATTGAAGATAGAGCTGCTTTATTTT
CTTGGTTTAAATCTTCCTTTATTTTTGTAGTGATGAGATGCTGATTGTGTACAGAAGAATTTGAGAGGGGATTTTTAAAAACTGACTTAA
CACACCCAGAAAGGCAGCTAACAGCTATATATATATATAAATTTCAGCCCAAACTCATGTTTTTAAACTCCAACTCTTAAAAGACAACAA
GGTATAAACTGAAATGAATCAACTTTCCACTTAGTTTCCAATTTTCCCCTAGTCCACTAATTAAACTTAGGTAATTATACTTCAGGTAGG
GAAGTACAATATGTTTAGTTTCAGGCTGATGTGTGTTATAAAAAACAACACTGAAAAATAAAAATGTACTTCCCTTCTAAGGAGCAAGCA
GGTGATGGTCATTCAAAGAGATGTCACATTGAATTATGAGAGAAACAATTTAGAGGTTTTTTTCCTGGCTTCATGAATTGTTCTATAGAG
TGGATGAAGTCTAAGGAAAAGTCCTCTTCATATATTTCCATTTATAAGCGTCTTGTTTTTGAAAGTGATCACAGCATGAAAATGACTGTG
CTGCTTTTTAGTGTCTGGCTGCATAATGTACAAGTCACAATTTGCTGTTTTTTTCAGGAGGAGAAAGGGAACCTCCTTTACTATTCTATA
TCCTAAAATCTACTTCTAATCAGCTTTATACTGTTGCCTGTACAGCTCAGTGAATGTACTTTCATCTTTAAGAGTTCAGATATATGCCAG
TGAATATTTTTGCTGTAGAGGAGAAAGTAAAAACTCCACAGCGGGGATCTTTTTCTTTGCTTTTGAAACCACCATTGAATCACTATCGTT
TTGCAGACTTTGCACAACTGTACAGGAGAGTGGCCTTTCTACAGCACATTTTCAGTAATCCTATATTTAGTCAAAATGGATGAGAAATCA
TGTATTAATGTTTGTATGGAATTTTGGGTCCAGTGTAATATTTTTATCATTTAAAAAGAACTCTATTTGTAAAAACATTTATTTACTGCA
TGGATATTGACGCACATTAAATTTGTGGGATTTTGTATATGTAAAAAAAAAAAAAAAAAAAAAACAAAAAACCTCTTGTCCTAAAATGAA
GTGTGCTTGTTAACAGGTGTTTAGACTTATTGATGTTTACTAGACCAAATGTGTATGTTCACTTAAAAATATATGTACCTGATGGATGTG
TCATGTTTACAGTGGCCAGGTTGTGGCCTGTAAACAGCAAGCAGTTGACGGGAAGACTAGCTCTGTTGCTACTAAGCAGCTTTTACTTTT
GTAAAGTCAGCTCTGTTGTTTTAAATGGTAAAAATTAAACTAATGAATTTGACAAGACTCGTGGCTAGCCTAGCATGAAAGAGACCTTTT
AACACTATATAATATCTGTACATTTTATTGCATTCGTTTCAAATCTAGGAGAGAGGCAGCACTGTAAACTGAAGTCAAATAAATTCAGCT

>5632_5632_2_APOO-CNKSR2_APOO_chrX_23897032_ENST00000379220_CNKSR2_chrX_21488884_ENST00000379510_length(amino acids)=940AA_BP=78
MFKVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQDCTVYETENKI
LHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQ
LKNLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPR
DEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYED
PNKMKRDSRRENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKSNSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQ
HKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKK
YAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVE
AKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQK
CHLQDHYGPYPLAESERMQVLNGNGGKPRSFTLPRDSGFNHCCLNAPVSACDPQDDVQPPEVEEEEEEEEEEGEAAGENIGEKSESREEK
LGDSLQDLYRALEQASLSPLGEHRISTKMEYKLSFIKRCNDPVMNEKLHRLRILKSTLKAREGEVAIIDKVLDNPDLTSKEFQQWKQMYL

--------------------------------------------------------------
>5632_5632_3_APOO-CNKSR2_APOO_chrX_23897032_ENST00000379220_CNKSR2_chrX_21488884_ENST00000425654_length(transcript)=5144nt_BP=475nt
GGGTTTGCGTTCACCCGCTGCCCGGGCGCGACGCGCTGCGGCTCAGCGACGCGGCTTCTAGAACCGGGTGATTGAACTAAACCTTCGCCG
CACCGAGTTTGCAGTACGGCCGTCACCCGCACCGCTGCCTGCTTGCGGTTGGAGAAATCAAGGCCCTACCGGGCCTCCGTAGTCACCTCT
CTATAGTGGGCGTGGCCGAGGCCGGGGTGACCCTGCCGGAGCCTCCGCTGCCAGCGACATGTTCAAGGTAATTCAGAGGTCCGTGGGGCC
AGCCAGCCTGAGCTTGCTCACCTTCAAAGTCTATGCAGCACCAAAAAAGGACTCACCTCCCAAAAATTCCGTGAAGGTTGATGAGCTTTC
ACTCTACTCAGTTCCTGAGGGTCAATCGAAGTATGTGGAGGAGGCAAGGAGCCAGCTTGAAGAAAGCATCTCACAGCTCCGACACTATTG
CGAGCCATACACAACCTGGTGTCAGGATTGTACTGTATATGAAACAGAGAATAAAATTCTTCACGTGTGTAAAACTCTTTCTGGAGTCTG
TGACCACATCATATCCCTGTCGTCAGATCCTCTGGTTTCACAGTCTGCTCACCTGGAAGTGATTCAACTGGCAAACATTAAACCAAGCGA
AGGGCTGGGTATGTATATTAAATCTACATATGATGGCCTCCATGTAATTACTGGAACCACAGAAAATTCACCTGCAGATCGGTGCAAGAA
AATCCATGCTGGCGATGAAGTGATTCAAGTTAATCATCAGACTGTGGTGGGGTGGCAGTTGAAAAATTTGGTGAATGCACTACGAGAGGA
CCCGAGTGGTGTTATCTTAACTTTGAAAAAGCGACCTCAGAGCATGCTTACCTCAGCACCAGCTTTACTGAAAAATATGAGATGGAAGCC
CCTTGCTCTGCAGCCTCTTATACCTAGAAGTCCCACAAGCAGCGTTGCCACGCCTTCCAGCACCATCAGTACACCCACCAAAAGAGACAG
TTCTGCCCTCCAGGATCTCTACATTCCCCCTCCTCCTGCAGAACCATATATTCCCAGGGATGAAAAAGGAAACCTTCCTTGTGAAGACCT
CAGAGGACATATGGTGGGCAAGCCAGTGCATAAGGGATCTGAATCACCAAATTCATTTCTGGATCAGGAATATCGAAAGAGATTTAATAT
TGTCGAAGAAGATACTGTCTTATATTGCTATGAATATGAAAAAGGAAGATCAAGTAGTCAAGGAAGACGAGAAAGCACCCCAACTTATGA
AAACTCTCTACTTCGGTATATGAGCAATGAAAAGATTGCTCAAGAAGAATACATGTTTCAGAGAAACAGCAAAAAGGACACAGGGAAGAA
GTCAAAAAAGAAGGGTGATAAGAGTAATAGCCCAACTCACTATTCATTGCTACCTAGTTTACAAATGGATGCACTGAGACAAGACATCAT
GGGCACTCCTGTGCCAGAGACCACACTATACCATACATTTCAGCAGTCCTCACTGCAGCACAAATCAAAGAAGAAAAACAAAGGTCCTAT
AGCAGGCAAGAGCAAAAGACGAATTTCTTGCAAAGATCTTGGCCGTGGTGACTGTGAGGGCTGGCTTTGGAAAAAGAAAGATGCGAAGAG
TTACTTTTCACAGAAATGGAAAAAATATTGGTTTGTCCTAAAGGATGCATCCCTTTATTGGTATATTAATGAGGAGGATGAAAAAGCAGA
AGGATTCATTAGCCTGCCTGAATTTAAAATTGATAGAGCCAGTGAATGCCGCAAAAAATATGCATTCAAAGCCTGTCATCCTAAAATCAA
AAGCTTTTATTTTGCTGCTGAACATCTTGATGATATGAACAGGTGGCTTAACAGAATTAATATGCTGACTGCAGGATATGCAGAAAGAGA
GAGGATTAAGCAGGAACAAGATTACTGGAGTGAGAGTGACAAGGAAGAAGCAGATACTCCATCAACACCAAAACAAGATAGCCCTCCACC
CCCATATGATACATACCCACGACCTCCCTCGATGAGTTGCGCCAGTCCTTATGTGGAAGCAAAACATAGCCGACTTTCCTCCACGGAGAC
TTCTCAGTCTCAGTCTTCTCATGAGGAGTTTCGCCAGGAAGTAACTGGGAGCAGTGCAGTGTCTCCCATTCGCAAGACAGCCAGTCAGCG
CCGCTCCTGGCAGGATTTAATTGAGACGCCACTGACAAGTTCAGGCTTACACTATCTTCAGACTCTGCCCCTGGAGGATTCTGTCTTCTC
TGACTCCGCGGCCATCTCCCCAGAGCACAGGCGGCAGTCTACCCTGCCAACTCAGAAATGCCACCTGCAGGATCACTATGGGCCATACCC
CTTAGCTGAGAGTGAGAGGATGCAAGTGCTAAATGGAAATGGGGGCAAGCCTCGAAGTTTTACTCTGCCTCGAGATAGCGGGTTCAACCA
TTGCTGTCTGAATGCTCCAGTTAGTGCCTGTGACCCACAGGATGACGTGCAACCCCCAGAGGTGGAGGAAGAGGAGGAGGAGGAGGAGGA
GGAAGGGGAGGCAGCAGGGGAAAACATAGGAGAAAAAAGTGAAAGCAGAGAAGAAAAGTTAGGAGACTCATTGCAAGATTTATACAGGGC
ACTGGAGCAGGCCAGTCTGTCACCACTAGGAGAACATCGTATTTCAACCAAGATGGAATACAAGCTATCATTTATAAAAAGATGTAATGA
TCCTGTAATGAATGAAAAACTACACCGGCTGAGAATTCTCAAAAGCACTTTAAAGGCCAGAGAAGGGGAAGTAGCCATTATCGATAAAGT
CCTAGACAATCCAGACTTGACATCTAAAGAATTCCAACAATGGAAGCAGATGTACCTCGACCTTTTCTTGGATATCTGTCAAAATACCAC
CTCAAATGACCCACTGAGTATTTCTTCTGAAGTAGATGTAATCACTTCCTCTCTAGCACACACTCATTCATACATTGAAACGCATGTCTA
AATGTATTCTGCCTTCAGACCATCTAGTACCTGCTGGTACTCTGAACAAGTATATAAGGTAGTTTTTATATCAATGTGTGGAACACTTGA
CAAGCTATACTTTAATGTTACCAAACTATATGAAACAAACCATATATGGTCACAATACCACTATCTTTAATGAGCATTTGTATATTTTAT
ATGCAACAGTGCTCAGCTTATGTTTACCATGTGCAAAATCAACTGTCTTTAATGACTTAAAATTAACTTTTGCAAACAATTCTAAATACA
GGTGGTCTTCAAGTAGTAAAACCACAAAAGGCAGTTTTCTATCTATGGTCATCTTTTCTCCCTTTAAGTTAATTTTATATAAACAAGACT
TCAAAAGTAAATCACATTTTTTCAGGTGCAGACATCCTTGTGGGTGGGAAAGAATTTAAACCTTTTTTATATTTATTAAAATGTTCTAAG
AATTTTCTTAAACATTGCACAAAGTTTAATGCTGTAGTTTTATTTTTGTGAAATGTAGATGCGCATACAAGAGCTAAGCAAAATAGAAGA
GCATCGACATAAGAAAAGTTCAGGTATCTAATATTCGTCTTAATAGTCTATTAACTTGTGAAAGCTAAGTTAATGGAAATATTATTCCAA
ATCTATGAGAACACTTGGTGTATCAGGGCAAAGCTTTGTAAGATGTTTTTGTAACTAAGACCAAAATTGAAGATAGAGCTGCTTTATTTT
CTTGGTTTAAATCTTCCTTTATTTTTGTAGTGATGAGATGCTGATTGTGTACAGAAGAATTTGAGAGGGGATTTTTAAAAACTGACTTAA
CACACCCAGAAAGGCAGCTAACAGCTATATATATATATAAATTTCAGCCCAAACTCATGTTTTTAAACTCCAACTCTTAAAAGACAACAA
GGTATAAACTGAAATGAATCAACTTTCCACTTAGTTTCCAATTTTCCCCTAGTCCACTAATTAAACTTAGGTAATTATACTTCAGGTAGG
GAAGTACAATATGTTTAGTTTCAGGCTGATGTGTGTTATAAAAAACAACACTGAAAAATAAAAATGTACTTCCCTTCTAAGGAGCAAGCA
GGTGATGGTCATTCAAAGAGATGTCACATTGAATTATGAGAGAAACAATTTAGAGGTTTTTTTCCTGGCTTCATGAATTGTTCTATAGAG
TGGATGAAGTCTAAGGAAAAGTCCTCTTCATATATTTCCATTTATAAGCGTCTTGTTTTTGAAAGTGATCACAGCATGAAAATGACTGTG
CTGCTTTTTAGTGTCTGGCTGCATAATGTACAAGTCACAATTTGCTGTTTTTTTCAGGAGGAGAAAGGGAACCTCCTTTACTATTCTATA
TCCTAAAATCTACTTCTAATCAGCTTTATACTGTTGCCTGTACAGCTCAGTGAATGTACTTTCATCTTTAAGAGTTCAGATATATGCCAG
TGAATATTTTTGCTGTAGAGGAGAAAGTAAAAACTCCACAGCGGGGATCTTTTTCTTTGCTTTTGAAACCACCATTGAATCACTATCGTT
TTGCAGACTTTGCACAACTGTACAGGAGAGTGGCCTTTCTACAGCACATTTTCAGTAATCCTATATTTAGTCAAAATGGATGAGAAATCA
TGTATTAATGTTTGTATGGAATTTTGGGTCCAGTGTAATATTTTTATCATTTAAAAAGAACTCTATTTGTAAAAACATTTATTTACTGCA
TGGATATTGACGCACATTAAATTTGTGGGATTTTGTATATGTAAAAAAAAAAAAAAAAAAAAAACAAAAAACCTCTTGTCCTAAAATGAA
GTGTGCTTGTTAACAGGTGTTTAGACTTATTGATGTTTACTAGACCAAATGTGTATGTTCACTTAAAAATATATGTACCTGATGGATGTG
TCATGTTTACAGTGGCCAGGTTGTGGCCTGTAAACAGCAAGCAGTTGACGGGAAGACTAGCTCTGTTGCTACTAAGCAGCTTTTACTTTT
GTAAAGTCAGCTCTGTTGTTTTAAATGGTAAAAATTAAACTAATGAATTTGACAAGACTCGTGGCTAGCCTAGCATGAAAGAGACCTTTT
AACACTATATAATATCTGTACATTTTATTGCATTCGTTTCAAATCTAGGAGAGAGGCAGCACTGTAAACTGAAGTCAAATAAATTCAGCT

>5632_5632_3_APOO-CNKSR2_APOO_chrX_23897032_ENST00000379220_CNKSR2_chrX_21488884_ENST00000425654_length(amino acids)=910AA_BP=78
MFKVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQDCTVYETENKI
LHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQ
LKNLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPR
DEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYENSLLRYMSNEKIAQEEYMF
QRNSKKDTGKKSKKKGDKSNSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQHKSKKKNKGPIAGKSKRRISCKDLGRGDCE
GWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRI
NMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQSSHEEFRQEVTGSSA
VSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGGKPRS
FTLPRDSGFNHCCLNAPVSACDPQDDVQPPEVEEEEEEEEEEGEAAGENIGEKSESREEKLGDSLQDLYRALEQASLSPLGEHRISTKME
YKLSFIKRCNDPVMNEKLHRLRILKSTLKAREGEVAIIDKVLDNPDLTSKEFQQWKQMYLDLFLDICQNTTSNDPLSISSEVDVITSSLA

--------------------------------------------------------------
>5632_5632_4_APOO-CNKSR2_APOO_chrX_23897032_ENST00000379220_CNKSR2_chrX_21488884_ENST00000543067_length(transcript)=3831nt_BP=475nt
GGGTTTGCGTTCACCCGCTGCCCGGGCGCGACGCGCTGCGGCTCAGCGACGCGGCTTCTAGAACCGGGTGATTGAACTAAACCTTCGCCG
CACCGAGTTTGCAGTACGGCCGTCACCCGCACCGCTGCCTGCTTGCGGTTGGAGAAATCAAGGCCCTACCGGGCCTCCGTAGTCACCTCT
CTATAGTGGGCGTGGCCGAGGCCGGGGTGACCCTGCCGGAGCCTCCGCTGCCAGCGACATGTTCAAGGTAATTCAGAGGTCCGTGGGGCC
AGCCAGCCTGAGCTTGCTCACCTTCAAAGTCTATGCAGCACCAAAAAAGGACTCACCTCCCAAAAATTCCGTGAAGGTTGATGAGCTTTC
ACTCTACTCAGTTCCTGAGGGTCAATCGAAGTATGTGGAGGAGGCAAGGAGCCAGCTTGAAGAAAGCATCTCACAGCTCCGACACTATTG
CGAGCCATACACAACCTGGTGTCAGGATTGTACTGTATATGAAACAGAGAATAAAATTCTTCACGTGTGTAAAACTCTTTCTGGAGTCTG
TGACCACATCATATCCCTGTCGTCAGATCCTCTGGTTTCACAGTCTGCTCACCTGGAAGTGATTCAACTGGCAAACATTAAACCAAGCGA
AGGGCTGGGTATGTATATTAAATCTACATATGATGGCCTCCATGTAATTACTGGAACCACAGAAAATTCACCTGCAGATCGGTGCAAGAA
AATCCATGCTGGCGATGAAGTGATTCAAGTTAATCATCAGACTGTGCCTCTTATACCTAGAAGTCCCACAAGCAGCGTTGCCACGCCTTC
CAGCACCATCAGTACACCCACCAAAAGAGACAGTTCTGCCCTCCAGGATCTCTACATTCCCCCTCCTCCTGCAGAACCATATATTCCCAG
GGATGAAAAAGGAAACCTTCCTTGTGAAGACCTCAGAGGACATATGGTGGGCAAGCCAGTGCATAAGGGATCTGAATCACCAAATTCATT
TCTGGATCAGGAATATCGAAAGAGATTTAATATTGTCGAAGAAGATACTGTCTTATATTGCTATGAATATGAAAAAGGAAGATCAAGTAG
TCAAGGAAGACGAGAAAGCACCCCAACTTATGGCAAGCTACGACCTATATCTATGCCAGTGGAATATAATTGGGTGGGGGACTATGAAGA
TCCAAATAAGATGAAGAGAGATAGTAGAAGAGAAAACTCTCTACTTCGGTATATGAGCAATGAAAAGATTGCTCAAGAAGAATACATGTT
TCAGAGAAACAGCAAAAAGGACACAGGGAAGAAGTCAAAAAAGAAGGGTGATAAGAGTAATAGCCCAACTCACTATTCATTGCTACCTAG
TTTACAAATGGATGCACTGAGACAAGACATCATGGGCACTCCTGTGCCAGAGACCACACTATACCATACATTTCAGCAGTCCTCACTGCA
GCACAAATCAAAGAAGAAAAACAAAGGTCCTATAGCAGGCAAGAGCAAAAGACGAATTTCTTGCAAAGATCTTGGCCGTGGTGACTGTGA
GGGCTGGCTTTGGAAAAAGAAAGATGCGAAGAGTTACTTTTCACAGAAATGGAAAAAATATTGGTTTGTCCTAAAGGATGCATCCCTTTA
TTGGTATATTAATGAGGAGGATGAAAAAGCAGAAGGATTCATTAGCCTGCCTGAATTTAAAATTGATAGAGCCAGTGAATGCCGCAAAAA
ATATGCATTCAAAGCCTGTCATCCTAAAATCAAAAGCTTTTATTTTGCTGCTGAACATCTTGATGATATGAACAGGTGGCTTAACAGAAT
TAATATGCTGACTGCAGGATATGCAGAAAGAGAGAGGATTAAGCAGGAACAAGATTACTGGAGTGAGAGTGACAAGGAAGAAGCAGATAC
TCCATCAACACCAAAACAAGATAGCCCTCCACCCCCATATGATACATACCCACGACCTCCCTCGATGAGTTGCGCCAGTCCTTATGTGGA
AGCAAAACATAGCCGACTTTCCTCCACGGAGACTTCTCAGTCTCAGTCTTCTCATGAGGAGTTTCGCCAGGAAGTAACTGGGAGCAGTGC
AGTGTCTCCCATTCGCAAGACAGCCAGTCAGCGCCGCTCCTGGCAGGATTTAATTGAGACGCCACTGACAAGTTCAGGCTTACACTATCT
TCAGACTCTGCCCCTGGAGGATTCTGTCTTCTCTGACTCCGCGGCCATCTCCCCAGAGCACAGGCGGCAGTCTACCCTGCCAACTCAGAA
ATGCCACCTGCAGGATCACTATGGGCCATACCCCTTAGCTGAGAGTGAGAGGATGCAAGTGCTAAATGGAAATGGGGGCAAGCCTCGAAG
TTTTACTCTGCCTCGAGATAGCGGGTTCAACCATTGCTGTCTGAATGCTCCAGTTAGTGCCTGTGACCCACAGGATGACGTGCAACCCCC
AGAGGTGGAGGAAGAGGAGGAGGAGGAGGAGGAGGAAGGGGAGGCAGCAGGGGAAAACATAGGAGAAAAAAGCTAATACACTGCGAGAGT
TGGTAGAACCTCTCCATGCCAAATCGGATCCACTTCTGTTGGCACTCAACCCATTGGACTCACAGATTGATAAGCTAATGTTTAGAGAAT
TTAGATCGGAGAGAGTCGGTACGGCGCAGACTCAACATCAACCTCTTGCAAGCAACTAAAATGGCCTCGTCCTTGCTGTTTATAACAGAA
AACAGACTTGTAAAAAGCTTAGATCATCAAGTGTTTTGGATTGGGGGCCTCCCAAAGGGATATAAGAGGGGCAGGCCACTCTTAAGAAGA
ATGCGAGCTTTCTACATTGGGACTAGCATAAGATCAAAGCCAATCAAGATGGAGCACAGTAACAGAAAACTGCGGTTTCTGTGGGAGAAC
AGAAGGGGAAAGGGTCTTAACTGGGAAAGGGCTCTGTGTGGTAACACCTCAGTTGTGTTCTCCTGACACCAGGAAAAGAGAGGGATCAGC
TTCAATAACTAGAAAATTCTGGCTGTTTAATGGACTCTTTGGTGGCCTCTTTAAGGCAAAGCAGAGAAAGCAAATTATGTATTAAGTGTA
TTTTGCATTTTTAAAACTTGACGTGCTGTATTGTACTAAATTAAGTGTAATCTATTAAGGCAAGGTATACACAATTTGCTTTGAAACTTA
CTATGTTTATTCTATTATAAAGTGTATTCAGGTGCAACACAGAGACTGCTTTCGGTGACATTAATGAAGAAAATTTCTCATGCCAGGCTT
TATTATAGAATCTTCAGCTAAAATCCTAACTTTCTCCTTATTTCTTGGCACTTGTATACAAGTGGTGTTGCCTCTTAGGGCAGGCATGAG
CTATTCTTTTCTGTAAAATATTTTGAATCTATAGGCTGTGGGTTTCATTTTTGAAAAGTATTTTGTCTGGATGTCTTTCAAACTAGCTTC
AGATATTATTTAATACTATGTAACTGGGTCCCCTATGGCTCAATCAATATTGCTTATTTTTCTTCTGTAGTGGATGTGAAATTTCCTTTA
GTTGGATAAGATACACTGTAATAATTTTAATGCTAATTAATGATATTTCATACTGTGCAATGAACAGATAATTTAACACTGTATTTTGAA
ATGTTTTTTTCTTCCTGTCACCGCAGTGTGTGGTATTGCATAATGTGAATACCTGTAAAAATATAAATTACTTAAAAATAAAAATATGAC
CAATTGGTATCAGATCTTTTCAGATAGCTAAATAATTTGCTAAGTATGCCTGATAGTAAATATCTTTCTAAAAAGAAGTAATCAGTGCTT

>5632_5632_4_APOO-CNKSR2_APOO_chrX_23897032_ENST00000379220_CNKSR2_chrX_21488884_ENST00000543067_length(amino acids)=755AA_BP=78
MFKVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQDCTVYETENKI
LHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVPLIP
RSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPRDEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLY
CYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYEDPNKMKRDSRRENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKS
NSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQHKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKK
YWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDY
WSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIE
TPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGGKPRSFTLPRDSGFNHCCLNAPVS

--------------------------------------------------------------
>5632_5632_5_APOO-CNKSR2_APOO_chrX_23897032_ENST00000379226_CNKSR2_chrX_21488884_ENST00000279451_length(transcript)=3972nt_BP=469nt
GCGTTCACCCGCTGCCCGGGCGCGACGCGCTGCGGCTCAGCGACGCGGCTTCTAGAACCGGGTGATTGAACTAAACCTTCGCCGCACCGA
GTTTGCAGTACGGCCGTCACCCGCACCGCTGCCTGCTTGCGGTTGGAGAAATCAAGGCCCTACCGGGCCTCCGTAGTCACCTCTCTATAG
TGGGCGTGGCCGAGGCCGGGGTGACCCTGCCGGAGCCTCCGCTGCCAGCGACATGTTCAAGGTAATTCAGAGGTCCGTGGGGCCAGCCAG
CCTGAGCTTGCTCACCTTCAAAGTCTATGCAGCACCAAAAAAGGACTCACCTCCCAAAAATTCCGTGAAGGTTGATGAGCTTTCACTCTA
CTCAGTTCCTGAGGGTCAATCGAAGTATGTGGAGGAGGCAAGGAGCCAGCTTGAAGAAAGCATCTCACAGCTCCGACACTATTGCGAGCC
ATACACAACCTGGTGTCAGGATTGTACTGTATATGAAACAGAGAATAAAATTCTTCACGTGTGTAAAACTCTTTCTGGAGTCTGTGACCA
CATCATATCCCTGTCGTCAGATCCTCTGGTTTCACAGTCTGCTCACCTGGAAGTGATTCAACTGGCAAACATTAAACCAAGCGAAGGGCT
GGGTATGTATATTAAATCTACATATGATGGCCTCCATGTAATTACTGGAACCACAGAAAATTCACCTGCAGATCGGTGCAAGAAAATCCA
TGCTGGCGATGAAGTGATTCAAGTTAATCATCAGACTGTGGTGGGGTGGCAGTTGAAAAATTTGGTGAATGCACTACGAGAGGACCCGAG
TGGTGTTATCTTAACTTTGAAAAAGCGACCTCAGAGCATGCTTACCTCAGCACCAGCTTTACTGAAAAATATGAGATGGAAGCCCCTTGC
TCTGCAGCCTCTTATACCTAGAAGTCCCACAAGCAGCGTTGCCACGCCTTCCAGCACCATCAGTACACCCACCAAAAGAGACAGTTCTGC
CCTCCAGGATCTCTACATTCCCCCTCCTCCTGCAGAACCATATATTCCCAGGGATGAAAAAGGAAACCTTCCTTGTGAAGACCTCAGAGG
ACATATGGTGGGCAAGCCAGTGCATAAGGGATCTGAATCACCAAATTCATTTCTGGATCAGGAATATCGAAAGAGATTTAATATTGTCGA
AGAAGATACTGTCTTATATTGCTATGAATATGAAAAAGGAAGATCAAGTAGTCAAGGAAGACGAGAAAGCACCCCAACTTATGGCAAGCT
ACGACCTATATCTATGCCAGTGGAATATAATTGGGTGGGGGACTATGAAGATCCAAATAAGATGAAGAGAGATAGTAGAAGAGAAAACTC
TCTACTTCGGTATATGAGCAATGAAAAGATTGCTCAAGAAGAATACATGTTTCAGAGAAACAGCAAAAAGGACACAGGGAAGAAGTCAAA
AAAGAAGGGTGATAAGAGTAATAGCCCAACTCACTATTCATTGCTACCTAGTTTACAAATGGATGCACTGAGACAAGACATCATGGGCAC
TCCTGTGCCAGAGACCACACTATACCATACATTTCAGCAGTCCTCACTGCAGCACAAATCAAAGAAGAAAAACAAAGGTCCTATAGCAGG
CAAGAGCAAAAGACGAATTTCTTGCAAAGATCTTGGCCGTGGTGACTGTGAGGGCTGGCTTTGGAAAAAGAAAGATGCGAAGAGTTACTT
TTCACAGAAATGGAAAAAATATTGGTTTGTCCTAAAGGATGCATCCCTTTATTGGTATATTAATGAGGAGGATGAAAAAGCAGAAGGATT
CATTAGCCTGCCTGAATTTAAAATTGATAGAGCCAGTGAATGCCGCAAAAAATATGCATTCAAAGCCTGTCATCCTAAAATCAAAAGCTT
TTATTTTGCTGCTGAACATCTTGATGATATGAACAGGTGGCTTAACAGAATTAATATGCTGACTGCAGGATATGCAGAAAGAGAGAGGAT
TAAGCAGGAACAAGATTACTGGAGTGAGAGTGACAAGGAAGAAGCAGATACTCCATCAACACCAAAACAAGATAGCCCTCCACCCCCATA
TGATACATACCCACGACCTCCCTCGATGAGTTGCGCCAGTCCTTATGTGGAAGCAAAACATAGCCGACTTTCCTCCACGGAGACTTCTCA
GTCTCAGTCTTCTCATGAGGAGTTTCGCCAGGAAGTAACTGGGAGCAGTGCAGTGTCTCCCATTCGCAAGACAGCCAGTCAGCGCCGCTC
CTGGCAGGATTTAATTGAGACGCCACTGACAAGTTCAGGCTTACACTATCTTCAGACTCTGCCCCTGGAGGATTCTGTCTTCTCTGACTC
CGCGGCCATCTCCCCAGAGCACAGGCGGCAGTCTACCCTGCCAACTCAGAAATGCCACCTGCAGGATCACTATGGGCCATACCCCTTAGC
TGAGAGTGAGAGGATGCAAGTGCTAAATGGAAATGGGGGCAAGCCTCGAAGTTTTACTCTGCCTCGAGATAGCGGGTTCAACCATTGCTG
TCTGAATGCTCCAGTTAGTGCCTGTGACCCACAGGATGACGTGCAACCCCCAGAGGTGGAGGAAGAGGAGGAGGAGGAGGAGGAGGAAGG
GGAGGCAGCAGGGGAAAACATAGGAGAAAAAAGCTAATACACTGCGAGAGTTGGTAGAACCTCTCCATGCCAAATCGGATCCACTTCTGT
TGGCACTCAACCCATTGGACTCACAGATTGATAAGCTAATGTTTAGAGAATTTAGATCGGAGAGAGTCGGTACGGCGCAGACTCAACATC
AACCTCTTGCAAGCAACTAAAATGGCCTCGTCCTTGCTGTTTATAACAGAAAACAGACTTGTAAAAAGCTTAGATCATCAAGTGTTTTGG
ATTGGGGGCCTCCCAAAGGGATATAAGAGGGGCAGGCCACTCTTAAGAAGAATGCGAGCTTTCTACATTGGGACTAGCATAAGATCAAAG
CCAATCAAGATGGAGCACAGTAACAGAAAACTGCGGTTTCTGTGGGAGAACAGAAGGGGAAAGGGTCTTAACTGGGAAAGGGCTCTGTGT
GGTAACACCTCAGTTGTGTTCTCCTGACACCAGGAAAAGAGAGGGATCAGCTTCAATAACTAGAAAATTCTGGCTGTTTAATGGACTCTT
TGGTGGCCTCTTTAAGGCAAAGCAGAGAAAGCAAATTATGTATTAAGTGTATTTTGCATTTTTAAAACTTGACGTGCTGTATTGTACTAA
ATTAAGTGTAATCTATTAAGGCAAGGTATACACAATTTGCTTTGAAACTTACTATGTTTATTCTATTATAAAGTGTATTCAGGTGCAACA
CAGAGACTGCTTTCGGTGACATTAATGAAGAAAATTTCTCATGCCAGGCTTTATTATAGAATCTTCAGCTAAAATCCTAACTTTCTCCTT
ATTTCTTGGCACTTGTATACAAGTGGTGTTGCCTCTTAGGGCAGGCATGAGCTATTCTTTTCTGTAAAATATTTTGAATCTATAGGCTGT
GGGTTTCATTTTTGAAAAGTATTTTGTCTGGATGTCTTTCAAACTAGCTTCAGATATTATTTAATACTATGTAACTGGGTCCCCTATGGC
TCAATCAATATTGCTTATTTTTCTTCTGTAGTGGATGTGAAATTTCCTTTAGTTGGATAAGATACACTGTAATAATTTTAATGCTAATTA
ATGATATTTCATACTGTGCAATGAACAGATAATTTAACACTGTATTTTGAAATGTTTTTTTCTTCCTGTCACCGCAGTGTGTGGTATTGC
ATAATGTGAATACCTGTAAAAATATAAATTACTTAAAAATAAAAATATGACCAATTGGTATCAGATCTTTTCAGATAGCTAAATAATTTG
CTAAGTATGCCTGATAGTAAATATCTTTCTAAAAAGAAGTAATCAGTGCTTCTTTCTCACAAATGGAATTTGTGTCTGTGAATAAAATCA

>5632_5632_5_APOO-CNKSR2_APOO_chrX_23897032_ENST00000379226_CNKSR2_chrX_21488884_ENST00000279451_length(amino acids)=804AA_BP=78
MFKVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQDCTVYETENKI
LHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQ
LKNLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPR
DEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYED
PNKMKRDSRRENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKSNSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQ
HKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKK
YAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVE
AKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQK

--------------------------------------------------------------
>5632_5632_6_APOO-CNKSR2_APOO_chrX_23897032_ENST00000379226_CNKSR2_chrX_21488884_ENST00000379510_length(transcript)=5229nt_BP=469nt
GCGTTCACCCGCTGCCCGGGCGCGACGCGCTGCGGCTCAGCGACGCGGCTTCTAGAACCGGGTGATTGAACTAAACCTTCGCCGCACCGA
GTTTGCAGTACGGCCGTCACCCGCACCGCTGCCTGCTTGCGGTTGGAGAAATCAAGGCCCTACCGGGCCTCCGTAGTCACCTCTCTATAG
TGGGCGTGGCCGAGGCCGGGGTGACCCTGCCGGAGCCTCCGCTGCCAGCGACATGTTCAAGGTAATTCAGAGGTCCGTGGGGCCAGCCAG
CCTGAGCTTGCTCACCTTCAAAGTCTATGCAGCACCAAAAAAGGACTCACCTCCCAAAAATTCCGTGAAGGTTGATGAGCTTTCACTCTA
CTCAGTTCCTGAGGGTCAATCGAAGTATGTGGAGGAGGCAAGGAGCCAGCTTGAAGAAAGCATCTCACAGCTCCGACACTATTGCGAGCC
ATACACAACCTGGTGTCAGGATTGTACTGTATATGAAACAGAGAATAAAATTCTTCACGTGTGTAAAACTCTTTCTGGAGTCTGTGACCA
CATCATATCCCTGTCGTCAGATCCTCTGGTTTCACAGTCTGCTCACCTGGAAGTGATTCAACTGGCAAACATTAAACCAAGCGAAGGGCT
GGGTATGTATATTAAATCTACATATGATGGCCTCCATGTAATTACTGGAACCACAGAAAATTCACCTGCAGATCGGTGCAAGAAAATCCA
TGCTGGCGATGAAGTGATTCAAGTTAATCATCAGACTGTGGTGGGGTGGCAGTTGAAAAATTTGGTGAATGCACTACGAGAGGACCCGAG
TGGTGTTATCTTAACTTTGAAAAAGCGACCTCAGAGCATGCTTACCTCAGCACCAGCTTTACTGAAAAATATGAGATGGAAGCCCCTTGC
TCTGCAGCCTCTTATACCTAGAAGTCCCACAAGCAGCGTTGCCACGCCTTCCAGCACCATCAGTACACCCACCAAAAGAGACAGTTCTGC
CCTCCAGGATCTCTACATTCCCCCTCCTCCTGCAGAACCATATATTCCCAGGGATGAAAAAGGAAACCTTCCTTGTGAAGACCTCAGAGG
ACATATGGTGGGCAAGCCAGTGCATAAGGGATCTGAATCACCAAATTCATTTCTGGATCAGGAATATCGAAAGAGATTTAATATTGTCGA
AGAAGATACTGTCTTATATTGCTATGAATATGAAAAAGGAAGATCAAGTAGTCAAGGAAGACGAGAAAGCACCCCAACTTATGGCAAGCT
ACGACCTATATCTATGCCAGTGGAATATAATTGGGTGGGGGACTATGAAGATCCAAATAAGATGAAGAGAGATAGTAGAAGAGAAAACTC
TCTACTTCGGTATATGAGCAATGAAAAGATTGCTCAAGAAGAATACATGTTTCAGAGAAACAGCAAAAAGGACACAGGGAAGAAGTCAAA
AAAGAAGGGTGATAAGAGTAATAGCCCAACTCACTATTCATTGCTACCTAGTTTACAAATGGATGCACTGAGACAAGACATCATGGGCAC
TCCTGTGCCAGAGACCACACTATACCATACATTTCAGCAGTCCTCACTGCAGCACAAATCAAAGAAGAAAAACAAAGGTCCTATAGCAGG
CAAGAGCAAAAGACGAATTTCTTGCAAAGATCTTGGCCGTGGTGACTGTGAGGGCTGGCTTTGGAAAAAGAAAGATGCGAAGAGTTACTT
TTCACAGAAATGGAAAAAATATTGGTTTGTCCTAAAGGATGCATCCCTTTATTGGTATATTAATGAGGAGGATGAAAAAGCAGAAGGATT
CATTAGCCTGCCTGAATTTAAAATTGATAGAGCCAGTGAATGCCGCAAAAAATATGCATTCAAAGCCTGTCATCCTAAAATCAAAAGCTT
TTATTTTGCTGCTGAACATCTTGATGATATGAACAGGTGGCTTAACAGAATTAATATGCTGACTGCAGGATATGCAGAAAGAGAGAGGAT
TAAGCAGGAACAAGATTACTGGAGTGAGAGTGACAAGGAAGAAGCAGATACTCCATCAACACCAAAACAAGATAGCCCTCCACCCCCATA
TGATACATACCCACGACCTCCCTCGATGAGTTGCGCCAGTCCTTATGTGGAAGCAAAACATAGCCGACTTTCCTCCACGGAGACTTCTCA
GTCTCAGTCTTCTCATGAGGAGTTTCGCCAGGAAGTAACTGGGAGCAGTGCAGTGTCTCCCATTCGCAAGACAGCCAGTCAGCGCCGCTC
CTGGCAGGATTTAATTGAGACGCCACTGACAAGTTCAGGCTTACACTATCTTCAGACTCTGCCCCTGGAGGATTCTGTCTTCTCTGACTC
CGCGGCCATCTCCCCAGAGCACAGGCGGCAGTCTACCCTGCCAACTCAGAAATGCCACCTGCAGGATCACTATGGGCCATACCCCTTAGC
TGAGAGTGAGAGGATGCAAGTGCTAAATGGAAATGGGGGCAAGCCTCGAAGTTTTACTCTGCCTCGAGATAGCGGGTTCAACCATTGCTG
TCTGAATGCTCCAGTTAGTGCCTGTGACCCACAGGATGACGTGCAACCCCCAGAGGTGGAGGAAGAGGAGGAGGAGGAGGAGGAGGAAGG
GGAGGCAGCAGGGGAAAACATAGGAGAAAAAAGTGAAAGCAGAGAAGAAAAGTTAGGAGACTCATTGCAAGATTTATACAGGGCACTGGA
GCAGGCCAGTCTGTCACCACTAGGAGAACATCGTATTTCAACCAAGATGGAATACAAGCTATCATTTATAAAAAGATGTAATGATCCTGT
AATGAATGAAAAACTACACCGGCTGAGAATTCTCAAAAGCACTTTAAAGGCCAGAGAAGGGGAAGTAGCCATTATCGATAAAGTCCTAGA
CAATCCAGACTTGACATCTAAAGAATTCCAACAATGGAAGCAGATGTACCTCGACCTTTTCTTGGATATCTGTCAAAATACCACCTCAAA
TGACCCACTGAGTATTTCTTCTGAAGTAGATGTAATCACTTCCTCTCTAGCACACACTCATTCATACATTGAAACGCATGTCTAAATGTA
TTCTGCCTTCAGACCATCTAGTACCTGCTGGTACTCTGAACAAGTATATAAGGTAGTTTTTATATCAATGTGTGGAACACTTGACAAGCT
ATACTTTAATGTTACCAAACTATATGAAACAAACCATATATGGTCACAATACCACTATCTTTAATGAGCATTTGTATATTTTATATGCAA
CAGTGCTCAGCTTATGTTTACCATGTGCAAAATCAACTGTCTTTAATGACTTAAAATTAACTTTTGCAAACAATTCTAAATACAGGTGGT
CTTCAAGTAGTAAAACCACAAAAGGCAGTTTTCTATCTATGGTCATCTTTTCTCCCTTTAAGTTAATTTTATATAAACAAGACTTCAAAA
GTAAATCACATTTTTTCAGGTGCAGACATCCTTGTGGGTGGGAAAGAATTTAAACCTTTTTTATATTTATTAAAATGTTCTAAGAATTTT
CTTAAACATTGCACAAAGTTTAATGCTGTAGTTTTATTTTTGTGAAATGTAGATGCGCATACAAGAGCTAAGCAAAATAGAAGAGCATCG
ACATAAGAAAAGTTCAGGTATCTAATATTCGTCTTAATAGTCTATTAACTTGTGAAAGCTAAGTTAATGGAAATATTATTCCAAATCTAT
GAGAACACTTGGTGTATCAGGGCAAAGCTTTGTAAGATGTTTTTGTAACTAAGACCAAAATTGAAGATAGAGCTGCTTTATTTTCTTGGT
TTAAATCTTCCTTTATTTTTGTAGTGATGAGATGCTGATTGTGTACAGAAGAATTTGAGAGGGGATTTTTAAAAACTGACTTAACACACC
CAGAAAGGCAGCTAACAGCTATATATATATATAAATTTCAGCCCAAACTCATGTTTTTAAACTCCAACTCTTAAAAGACAACAAGGTATA
AACTGAAATGAATCAACTTTCCACTTAGTTTCCAATTTTCCCCTAGTCCACTAATTAAACTTAGGTAATTATACTTCAGGTAGGGAAGTA
CAATATGTTTAGTTTCAGGCTGATGTGTGTTATAAAAAACAACACTGAAAAATAAAAATGTACTTCCCTTCTAAGGAGCAAGCAGGTGAT
GGTCATTCAAAGAGATGTCACATTGAATTATGAGAGAAACAATTTAGAGGTTTTTTTCCTGGCTTCATGAATTGTTCTATAGAGTGGATG
AAGTCTAAGGAAAAGTCCTCTTCATATATTTCCATTTATAAGCGTCTTGTTTTTGAAAGTGATCACAGCATGAAAATGACTGTGCTGCTT
TTTAGTGTCTGGCTGCATAATGTACAAGTCACAATTTGCTGTTTTTTTCAGGAGGAGAAAGGGAACCTCCTTTACTATTCTATATCCTAA
AATCTACTTCTAATCAGCTTTATACTGTTGCCTGTACAGCTCAGTGAATGTACTTTCATCTTTAAGAGTTCAGATATATGCCAGTGAATA
TTTTTGCTGTAGAGGAGAAAGTAAAAACTCCACAGCGGGGATCTTTTTCTTTGCTTTTGAAACCACCATTGAATCACTATCGTTTTGCAG
ACTTTGCACAACTGTACAGGAGAGTGGCCTTTCTACAGCACATTTTCAGTAATCCTATATTTAGTCAAAATGGATGAGAAATCATGTATT
AATGTTTGTATGGAATTTTGGGTCCAGTGTAATATTTTTATCATTTAAAAAGAACTCTATTTGTAAAAACATTTATTTACTGCATGGATA
TTGACGCACATTAAATTTGTGGGATTTTGTATATGTAAAAAAAAAAAAAAAAAAAAAACAAAAAACCTCTTGTCCTAAAATGAAGTGTGC
TTGTTAACAGGTGTTTAGACTTATTGATGTTTACTAGACCAAATGTGTATGTTCACTTAAAAATATATGTACCTGATGGATGTGTCATGT
TTACAGTGGCCAGGTTGTGGCCTGTAAACAGCAAGCAGTTGACGGGAAGACTAGCTCTGTTGCTACTAAGCAGCTTTTACTTTTGTAAAG
TCAGCTCTGTTGTTTTAAATGGTAAAAATTAAACTAATGAATTTGACAAGACTCGTGGCTAGCCTAGCATGAAAGAGACCTTTTAACACT
ATATAATATCTGTACATTTTATTGCATTCGTTTCAAATCTAGGAGAGAGGCAGCACTGTAAACTGAAGTCAAATAAATTCAGCTCTTAAT

>5632_5632_6_APOO-CNKSR2_APOO_chrX_23897032_ENST00000379226_CNKSR2_chrX_21488884_ENST00000379510_length(amino acids)=940AA_BP=78
MFKVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQDCTVYETENKI
LHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQ
LKNLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPR
DEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYED
PNKMKRDSRRENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKSNSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQ
HKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKK
YAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVE
AKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQK
CHLQDHYGPYPLAESERMQVLNGNGGKPRSFTLPRDSGFNHCCLNAPVSACDPQDDVQPPEVEEEEEEEEEEGEAAGENIGEKSESREEK
LGDSLQDLYRALEQASLSPLGEHRISTKMEYKLSFIKRCNDPVMNEKLHRLRILKSTLKAREGEVAIIDKVLDNPDLTSKEFQQWKQMYL

--------------------------------------------------------------
>5632_5632_7_APOO-CNKSR2_APOO_chrX_23897032_ENST00000379226_CNKSR2_chrX_21488884_ENST00000425654_length(transcript)=5138nt_BP=469nt
GCGTTCACCCGCTGCCCGGGCGCGACGCGCTGCGGCTCAGCGACGCGGCTTCTAGAACCGGGTGATTGAACTAAACCTTCGCCGCACCGA
GTTTGCAGTACGGCCGTCACCCGCACCGCTGCCTGCTTGCGGTTGGAGAAATCAAGGCCCTACCGGGCCTCCGTAGTCACCTCTCTATAG
TGGGCGTGGCCGAGGCCGGGGTGACCCTGCCGGAGCCTCCGCTGCCAGCGACATGTTCAAGGTAATTCAGAGGTCCGTGGGGCCAGCCAG
CCTGAGCTTGCTCACCTTCAAAGTCTATGCAGCACCAAAAAAGGACTCACCTCCCAAAAATTCCGTGAAGGTTGATGAGCTTTCACTCTA
CTCAGTTCCTGAGGGTCAATCGAAGTATGTGGAGGAGGCAAGGAGCCAGCTTGAAGAAAGCATCTCACAGCTCCGACACTATTGCGAGCC
ATACACAACCTGGTGTCAGGATTGTACTGTATATGAAACAGAGAATAAAATTCTTCACGTGTGTAAAACTCTTTCTGGAGTCTGTGACCA
CATCATATCCCTGTCGTCAGATCCTCTGGTTTCACAGTCTGCTCACCTGGAAGTGATTCAACTGGCAAACATTAAACCAAGCGAAGGGCT
GGGTATGTATATTAAATCTACATATGATGGCCTCCATGTAATTACTGGAACCACAGAAAATTCACCTGCAGATCGGTGCAAGAAAATCCA
TGCTGGCGATGAAGTGATTCAAGTTAATCATCAGACTGTGGTGGGGTGGCAGTTGAAAAATTTGGTGAATGCACTACGAGAGGACCCGAG
TGGTGTTATCTTAACTTTGAAAAAGCGACCTCAGAGCATGCTTACCTCAGCACCAGCTTTACTGAAAAATATGAGATGGAAGCCCCTTGC
TCTGCAGCCTCTTATACCTAGAAGTCCCACAAGCAGCGTTGCCACGCCTTCCAGCACCATCAGTACACCCACCAAAAGAGACAGTTCTGC
CCTCCAGGATCTCTACATTCCCCCTCCTCCTGCAGAACCATATATTCCCAGGGATGAAAAAGGAAACCTTCCTTGTGAAGACCTCAGAGG
ACATATGGTGGGCAAGCCAGTGCATAAGGGATCTGAATCACCAAATTCATTTCTGGATCAGGAATATCGAAAGAGATTTAATATTGTCGA
AGAAGATACTGTCTTATATTGCTATGAATATGAAAAAGGAAGATCAAGTAGTCAAGGAAGACGAGAAAGCACCCCAACTTATGAAAACTC
TCTACTTCGGTATATGAGCAATGAAAAGATTGCTCAAGAAGAATACATGTTTCAGAGAAACAGCAAAAAGGACACAGGGAAGAAGTCAAA
AAAGAAGGGTGATAAGAGTAATAGCCCAACTCACTATTCATTGCTACCTAGTTTACAAATGGATGCACTGAGACAAGACATCATGGGCAC
TCCTGTGCCAGAGACCACACTATACCATACATTTCAGCAGTCCTCACTGCAGCACAAATCAAAGAAGAAAAACAAAGGTCCTATAGCAGG
CAAGAGCAAAAGACGAATTTCTTGCAAAGATCTTGGCCGTGGTGACTGTGAGGGCTGGCTTTGGAAAAAGAAAGATGCGAAGAGTTACTT
TTCACAGAAATGGAAAAAATATTGGTTTGTCCTAAAGGATGCATCCCTTTATTGGTATATTAATGAGGAGGATGAAAAAGCAGAAGGATT
CATTAGCCTGCCTGAATTTAAAATTGATAGAGCCAGTGAATGCCGCAAAAAATATGCATTCAAAGCCTGTCATCCTAAAATCAAAAGCTT
TTATTTTGCTGCTGAACATCTTGATGATATGAACAGGTGGCTTAACAGAATTAATATGCTGACTGCAGGATATGCAGAAAGAGAGAGGAT
TAAGCAGGAACAAGATTACTGGAGTGAGAGTGACAAGGAAGAAGCAGATACTCCATCAACACCAAAACAAGATAGCCCTCCACCCCCATA
TGATACATACCCACGACCTCCCTCGATGAGTTGCGCCAGTCCTTATGTGGAAGCAAAACATAGCCGACTTTCCTCCACGGAGACTTCTCA
GTCTCAGTCTTCTCATGAGGAGTTTCGCCAGGAAGTAACTGGGAGCAGTGCAGTGTCTCCCATTCGCAAGACAGCCAGTCAGCGCCGCTC
CTGGCAGGATTTAATTGAGACGCCACTGACAAGTTCAGGCTTACACTATCTTCAGACTCTGCCCCTGGAGGATTCTGTCTTCTCTGACTC
CGCGGCCATCTCCCCAGAGCACAGGCGGCAGTCTACCCTGCCAACTCAGAAATGCCACCTGCAGGATCACTATGGGCCATACCCCTTAGC
TGAGAGTGAGAGGATGCAAGTGCTAAATGGAAATGGGGGCAAGCCTCGAAGTTTTACTCTGCCTCGAGATAGCGGGTTCAACCATTGCTG
TCTGAATGCTCCAGTTAGTGCCTGTGACCCACAGGATGACGTGCAACCCCCAGAGGTGGAGGAAGAGGAGGAGGAGGAGGAGGAGGAAGG
GGAGGCAGCAGGGGAAAACATAGGAGAAAAAAGTGAAAGCAGAGAAGAAAAGTTAGGAGACTCATTGCAAGATTTATACAGGGCACTGGA
GCAGGCCAGTCTGTCACCACTAGGAGAACATCGTATTTCAACCAAGATGGAATACAAGCTATCATTTATAAAAAGATGTAATGATCCTGT
AATGAATGAAAAACTACACCGGCTGAGAATTCTCAAAAGCACTTTAAAGGCCAGAGAAGGGGAAGTAGCCATTATCGATAAAGTCCTAGA
CAATCCAGACTTGACATCTAAAGAATTCCAACAATGGAAGCAGATGTACCTCGACCTTTTCTTGGATATCTGTCAAAATACCACCTCAAA
TGACCCACTGAGTATTTCTTCTGAAGTAGATGTAATCACTTCCTCTCTAGCACACACTCATTCATACATTGAAACGCATGTCTAAATGTA
TTCTGCCTTCAGACCATCTAGTACCTGCTGGTACTCTGAACAAGTATATAAGGTAGTTTTTATATCAATGTGTGGAACACTTGACAAGCT
ATACTTTAATGTTACCAAACTATATGAAACAAACCATATATGGTCACAATACCACTATCTTTAATGAGCATTTGTATATTTTATATGCAA
CAGTGCTCAGCTTATGTTTACCATGTGCAAAATCAACTGTCTTTAATGACTTAAAATTAACTTTTGCAAACAATTCTAAATACAGGTGGT
CTTCAAGTAGTAAAACCACAAAAGGCAGTTTTCTATCTATGGTCATCTTTTCTCCCTTTAAGTTAATTTTATATAAACAAGACTTCAAAA
GTAAATCACATTTTTTCAGGTGCAGACATCCTTGTGGGTGGGAAAGAATTTAAACCTTTTTTATATTTATTAAAATGTTCTAAGAATTTT
CTTAAACATTGCACAAAGTTTAATGCTGTAGTTTTATTTTTGTGAAATGTAGATGCGCATACAAGAGCTAAGCAAAATAGAAGAGCATCG
ACATAAGAAAAGTTCAGGTATCTAATATTCGTCTTAATAGTCTATTAACTTGTGAAAGCTAAGTTAATGGAAATATTATTCCAAATCTAT
GAGAACACTTGGTGTATCAGGGCAAAGCTTTGTAAGATGTTTTTGTAACTAAGACCAAAATTGAAGATAGAGCTGCTTTATTTTCTTGGT
TTAAATCTTCCTTTATTTTTGTAGTGATGAGATGCTGATTGTGTACAGAAGAATTTGAGAGGGGATTTTTAAAAACTGACTTAACACACC
CAGAAAGGCAGCTAACAGCTATATATATATATAAATTTCAGCCCAAACTCATGTTTTTAAACTCCAACTCTTAAAAGACAACAAGGTATA
AACTGAAATGAATCAACTTTCCACTTAGTTTCCAATTTTCCCCTAGTCCACTAATTAAACTTAGGTAATTATACTTCAGGTAGGGAAGTA
CAATATGTTTAGTTTCAGGCTGATGTGTGTTATAAAAAACAACACTGAAAAATAAAAATGTACTTCCCTTCTAAGGAGCAAGCAGGTGAT
GGTCATTCAAAGAGATGTCACATTGAATTATGAGAGAAACAATTTAGAGGTTTTTTTCCTGGCTTCATGAATTGTTCTATAGAGTGGATG
AAGTCTAAGGAAAAGTCCTCTTCATATATTTCCATTTATAAGCGTCTTGTTTTTGAAAGTGATCACAGCATGAAAATGACTGTGCTGCTT
TTTAGTGTCTGGCTGCATAATGTACAAGTCACAATTTGCTGTTTTTTTCAGGAGGAGAAAGGGAACCTCCTTTACTATTCTATATCCTAA
AATCTACTTCTAATCAGCTTTATACTGTTGCCTGTACAGCTCAGTGAATGTACTTTCATCTTTAAGAGTTCAGATATATGCCAGTGAATA
TTTTTGCTGTAGAGGAGAAAGTAAAAACTCCACAGCGGGGATCTTTTTCTTTGCTTTTGAAACCACCATTGAATCACTATCGTTTTGCAG
ACTTTGCACAACTGTACAGGAGAGTGGCCTTTCTACAGCACATTTTCAGTAATCCTATATTTAGTCAAAATGGATGAGAAATCATGTATT
AATGTTTGTATGGAATTTTGGGTCCAGTGTAATATTTTTATCATTTAAAAAGAACTCTATTTGTAAAAACATTTATTTACTGCATGGATA
TTGACGCACATTAAATTTGTGGGATTTTGTATATGTAAAAAAAAAAAAAAAAAAAAAACAAAAAACCTCTTGTCCTAAAATGAAGTGTGC
TTGTTAACAGGTGTTTAGACTTATTGATGTTTACTAGACCAAATGTGTATGTTCACTTAAAAATATATGTACCTGATGGATGTGTCATGT
TTACAGTGGCCAGGTTGTGGCCTGTAAACAGCAAGCAGTTGACGGGAAGACTAGCTCTGTTGCTACTAAGCAGCTTTTACTTTTGTAAAG
TCAGCTCTGTTGTTTTAAATGGTAAAAATTAAACTAATGAATTTGACAAGACTCGTGGCTAGCCTAGCATGAAAGAGACCTTTTAACACT
ATATAATATCTGTACATTTTATTGCATTCGTTTCAAATCTAGGAGAGAGGCAGCACTGTAAACTGAAGTCAAATAAATTCAGCTCTTAAT

>5632_5632_7_APOO-CNKSR2_APOO_chrX_23897032_ENST00000379226_CNKSR2_chrX_21488884_ENST00000425654_length(amino acids)=910AA_BP=78
MFKVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQDCTVYETENKI
LHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQ
LKNLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPR
DEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYENSLLRYMSNEKIAQEEYMF
QRNSKKDTGKKSKKKGDKSNSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQHKSKKKNKGPIAGKSKRRISCKDLGRGDCE
GWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRI
NMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQSSHEEFRQEVTGSSA
VSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGGKPRS
FTLPRDSGFNHCCLNAPVSACDPQDDVQPPEVEEEEEEEEEEGEAAGENIGEKSESREEKLGDSLQDLYRALEQASLSPLGEHRISTKME
YKLSFIKRCNDPVMNEKLHRLRILKSTLKAREGEVAIIDKVLDNPDLTSKEFQQWKQMYLDLFLDICQNTTSNDPLSISSEVDVITSSLA

--------------------------------------------------------------
>5632_5632_8_APOO-CNKSR2_APOO_chrX_23897032_ENST00000379226_CNKSR2_chrX_21488884_ENST00000543067_length(transcript)=3825nt_BP=469nt
GCGTTCACCCGCTGCCCGGGCGCGACGCGCTGCGGCTCAGCGACGCGGCTTCTAGAACCGGGTGATTGAACTAAACCTTCGCCGCACCGA
GTTTGCAGTACGGCCGTCACCCGCACCGCTGCCTGCTTGCGGTTGGAGAAATCAAGGCCCTACCGGGCCTCCGTAGTCACCTCTCTATAG
TGGGCGTGGCCGAGGCCGGGGTGACCCTGCCGGAGCCTCCGCTGCCAGCGACATGTTCAAGGTAATTCAGAGGTCCGTGGGGCCAGCCAG
CCTGAGCTTGCTCACCTTCAAAGTCTATGCAGCACCAAAAAAGGACTCACCTCCCAAAAATTCCGTGAAGGTTGATGAGCTTTCACTCTA
CTCAGTTCCTGAGGGTCAATCGAAGTATGTGGAGGAGGCAAGGAGCCAGCTTGAAGAAAGCATCTCACAGCTCCGACACTATTGCGAGCC
ATACACAACCTGGTGTCAGGATTGTACTGTATATGAAACAGAGAATAAAATTCTTCACGTGTGTAAAACTCTTTCTGGAGTCTGTGACCA
CATCATATCCCTGTCGTCAGATCCTCTGGTTTCACAGTCTGCTCACCTGGAAGTGATTCAACTGGCAAACATTAAACCAAGCGAAGGGCT
GGGTATGTATATTAAATCTACATATGATGGCCTCCATGTAATTACTGGAACCACAGAAAATTCACCTGCAGATCGGTGCAAGAAAATCCA
TGCTGGCGATGAAGTGATTCAAGTTAATCATCAGACTGTGCCTCTTATACCTAGAAGTCCCACAAGCAGCGTTGCCACGCCTTCCAGCAC
CATCAGTACACCCACCAAAAGAGACAGTTCTGCCCTCCAGGATCTCTACATTCCCCCTCCTCCTGCAGAACCATATATTCCCAGGGATGA
AAAAGGAAACCTTCCTTGTGAAGACCTCAGAGGACATATGGTGGGCAAGCCAGTGCATAAGGGATCTGAATCACCAAATTCATTTCTGGA
TCAGGAATATCGAAAGAGATTTAATATTGTCGAAGAAGATACTGTCTTATATTGCTATGAATATGAAAAAGGAAGATCAAGTAGTCAAGG
AAGACGAGAAAGCACCCCAACTTATGGCAAGCTACGACCTATATCTATGCCAGTGGAATATAATTGGGTGGGGGACTATGAAGATCCAAA
TAAGATGAAGAGAGATAGTAGAAGAGAAAACTCTCTACTTCGGTATATGAGCAATGAAAAGATTGCTCAAGAAGAATACATGTTTCAGAG
AAACAGCAAAAAGGACACAGGGAAGAAGTCAAAAAAGAAGGGTGATAAGAGTAATAGCCCAACTCACTATTCATTGCTACCTAGTTTACA
AATGGATGCACTGAGACAAGACATCATGGGCACTCCTGTGCCAGAGACCACACTATACCATACATTTCAGCAGTCCTCACTGCAGCACAA
ATCAAAGAAGAAAAACAAAGGTCCTATAGCAGGCAAGAGCAAAAGACGAATTTCTTGCAAAGATCTTGGCCGTGGTGACTGTGAGGGCTG
GCTTTGGAAAAAGAAAGATGCGAAGAGTTACTTTTCACAGAAATGGAAAAAATATTGGTTTGTCCTAAAGGATGCATCCCTTTATTGGTA
TATTAATGAGGAGGATGAAAAAGCAGAAGGATTCATTAGCCTGCCTGAATTTAAAATTGATAGAGCCAGTGAATGCCGCAAAAAATATGC
ATTCAAAGCCTGTCATCCTAAAATCAAAAGCTTTTATTTTGCTGCTGAACATCTTGATGATATGAACAGGTGGCTTAACAGAATTAATAT
GCTGACTGCAGGATATGCAGAAAGAGAGAGGATTAAGCAGGAACAAGATTACTGGAGTGAGAGTGACAAGGAAGAAGCAGATACTCCATC
AACACCAAAACAAGATAGCCCTCCACCCCCATATGATACATACCCACGACCTCCCTCGATGAGTTGCGCCAGTCCTTATGTGGAAGCAAA
ACATAGCCGACTTTCCTCCACGGAGACTTCTCAGTCTCAGTCTTCTCATGAGGAGTTTCGCCAGGAAGTAACTGGGAGCAGTGCAGTGTC
TCCCATTCGCAAGACAGCCAGTCAGCGCCGCTCCTGGCAGGATTTAATTGAGACGCCACTGACAAGTTCAGGCTTACACTATCTTCAGAC
TCTGCCCCTGGAGGATTCTGTCTTCTCTGACTCCGCGGCCATCTCCCCAGAGCACAGGCGGCAGTCTACCCTGCCAACTCAGAAATGCCA
CCTGCAGGATCACTATGGGCCATACCCCTTAGCTGAGAGTGAGAGGATGCAAGTGCTAAATGGAAATGGGGGCAAGCCTCGAAGTTTTAC
TCTGCCTCGAGATAGCGGGTTCAACCATTGCTGTCTGAATGCTCCAGTTAGTGCCTGTGACCCACAGGATGACGTGCAACCCCCAGAGGT
GGAGGAAGAGGAGGAGGAGGAGGAGGAGGAAGGGGAGGCAGCAGGGGAAAACATAGGAGAAAAAAGCTAATACACTGCGAGAGTTGGTAG
AACCTCTCCATGCCAAATCGGATCCACTTCTGTTGGCACTCAACCCATTGGACTCACAGATTGATAAGCTAATGTTTAGAGAATTTAGAT
CGGAGAGAGTCGGTACGGCGCAGACTCAACATCAACCTCTTGCAAGCAACTAAAATGGCCTCGTCCTTGCTGTTTATAACAGAAAACAGA
CTTGTAAAAAGCTTAGATCATCAAGTGTTTTGGATTGGGGGCCTCCCAAAGGGATATAAGAGGGGCAGGCCACTCTTAAGAAGAATGCGA
GCTTTCTACATTGGGACTAGCATAAGATCAAAGCCAATCAAGATGGAGCACAGTAACAGAAAACTGCGGTTTCTGTGGGAGAACAGAAGG
GGAAAGGGTCTTAACTGGGAAAGGGCTCTGTGTGGTAACACCTCAGTTGTGTTCTCCTGACACCAGGAAAAGAGAGGGATCAGCTTCAAT
AACTAGAAAATTCTGGCTGTTTAATGGACTCTTTGGTGGCCTCTTTAAGGCAAAGCAGAGAAAGCAAATTATGTATTAAGTGTATTTTGC
ATTTTTAAAACTTGACGTGCTGTATTGTACTAAATTAAGTGTAATCTATTAAGGCAAGGTATACACAATTTGCTTTGAAACTTACTATGT
TTATTCTATTATAAAGTGTATTCAGGTGCAACACAGAGACTGCTTTCGGTGACATTAATGAAGAAAATTTCTCATGCCAGGCTTTATTAT
AGAATCTTCAGCTAAAATCCTAACTTTCTCCTTATTTCTTGGCACTTGTATACAAGTGGTGTTGCCTCTTAGGGCAGGCATGAGCTATTC
TTTTCTGTAAAATATTTTGAATCTATAGGCTGTGGGTTTCATTTTTGAAAAGTATTTTGTCTGGATGTCTTTCAAACTAGCTTCAGATAT
TATTTAATACTATGTAACTGGGTCCCCTATGGCTCAATCAATATTGCTTATTTTTCTTCTGTAGTGGATGTGAAATTTCCTTTAGTTGGA
TAAGATACACTGTAATAATTTTAATGCTAATTAATGATATTTCATACTGTGCAATGAACAGATAATTTAACACTGTATTTTGAAATGTTT
TTTTCTTCCTGTCACCGCAGTGTGTGGTATTGCATAATGTGAATACCTGTAAAAATATAAATTACTTAAAAATAAAAATATGACCAATTG
GTATCAGATCTTTTCAGATAGCTAAATAATTTGCTAAGTATGCCTGATAGTAAATATCTTTCTAAAAAGAAGTAATCAGTGCTTCTTTCT

>5632_5632_8_APOO-CNKSR2_APOO_chrX_23897032_ENST00000379226_CNKSR2_chrX_21488884_ENST00000543067_length(amino acids)=755AA_BP=78
MFKVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQDCTVYETENKI
LHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVPLIP
RSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPRDEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLY
CYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYEDPNKMKRDSRRENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKS
NSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQHKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKK
YWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDY
WSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIE
TPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGGKPRSFTLPRDSGFNHCCLNAPVS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for APOO-CNKSR2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for APOO-CNKSR2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for APOO-CNKSR2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgeneC2931498Mental Retardation, X-Linked 11ORPHANET
TgeneC4538788MENTAL RETARDATION, X-LINKED, SYNDROMIC, HOUGE TYPE1GENOMICS_ENGLAND