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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DERL1-ATAD2 (FusionGDB2 ID:HG79139TG29028)

Fusion Gene Summary for DERL1-ATAD2

check button Fusion gene summary
Fusion gene informationFusion gene name: DERL1-ATAD2
Fusion gene ID: hg79139tg29028
HgeneTgene
Gene symbol

DERL1

ATAD2

Gene ID

79139

29028

Gene namederlin 1ATPase family AAA domain containing 2
SynonymsDER-1|DER1|derlin-1ANCCA|CT137|PRO2000
Cytomap('DERL1')('ATAD2')

8q24.13

8q24.13

Type of geneprotein-codingprotein-coding
Descriptionderlin-1DERtrin-1Der1-like domain family, member 1degradation in endoplasmic reticulum protein 1ATPase family AAA domain-containing protein 2AAA nuclear coregulator cancer-associated protein
Modification date2020032720200322
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000259512, ENST00000405944, 
ENST00000419562, ENST00000519018, 
ENST00000523036, 
Fusion gene scores* DoF score3 X 3 X 3=277 X 6 X 8=336
# samples 49
** MAII scorelog2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(9/336*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DERL1 [Title/Abstract] AND ATAD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDERL1(124054210)-ATAD2(124392917), # samples:1
Anticipated loss of major functional domain due to fusion event.DERL1-ATAD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DERL1-ATAD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDERL1

GO:0030433

ubiquitin-dependent ERAD pathway

15215856|17872946

HgeneDERL1

GO:0030968

endoplasmic reticulum unfolded protein response

15215856

HgeneDERL1

GO:0030970

retrograde protein transport, ER to cytosol

15215856

HgeneDERL1

GO:0031398

positive regulation of protein ubiquitination

24089527

TgeneATAD2

GO:0045893

positive regulation of transcription, DNA-templated

17998543


check buttonFusion gene breakpoints across DERL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ATAD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4QI-01ADERL1chr8

124054210

-ATAD2chr8

124392917

-


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Fusion Gene ORF analysis for DERL1-ATAD2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000259512ENST00000521903DERL1chr8

124054210

-ATAD2chr8

124392917

-
5CDS-5UTRENST00000405944ENST00000521903DERL1chr8

124054210

-ATAD2chr8

124392917

-
5CDS-5UTRENST00000419562ENST00000521903DERL1chr8

124054210

-ATAD2chr8

124392917

-
5CDS-intronENST00000259512ENST00000534257DERL1chr8

124054210

-ATAD2chr8

124392917

-
5CDS-intronENST00000405944ENST00000534257DERL1chr8

124054210

-ATAD2chr8

124392917

-
5CDS-intronENST00000419562ENST00000534257DERL1chr8

124054210

-ATAD2chr8

124392917

-
In-frameENST00000259512ENST00000287394DERL1chr8

124054210

-ATAD2chr8

124392917

-
In-frameENST00000405944ENST00000287394DERL1chr8

124054210

-ATAD2chr8

124392917

-
In-frameENST00000419562ENST00000287394DERL1chr8

124054210

-ATAD2chr8

124392917

-
intron-3CDSENST00000519018ENST00000287394DERL1chr8

124054210

-ATAD2chr8

124392917

-
intron-3CDSENST00000523036ENST00000287394DERL1chr8

124054210

-ATAD2chr8

124392917

-
intron-5UTRENST00000519018ENST00000521903DERL1chr8

124054210

-ATAD2chr8

124392917

-
intron-5UTRENST00000523036ENST00000521903DERL1chr8

124054210

-ATAD2chr8

124392917

-
intron-intronENST00000519018ENST00000534257DERL1chr8

124054210

-ATAD2chr8

124392917

-
intron-intronENST00000523036ENST00000534257DERL1chr8

124054210

-ATAD2chr8

124392917

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000259512DERL1chr8124054210-ENST00000287394ATAD2chr8124392917-574045427144551394
ENST00000405944DERL1chr8124054210-ENST00000287394ATAD2chr8124392917-5439153041541384
ENST00000419562DERL1chr8124054210-ENST00000287394ATAD2chr8124392917-561933315043341394

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000259512ENST00000287394DERL1chr8124054210-ATAD2chr8124392917-0.0001813060.99981874
ENST00000405944ENST00000287394DERL1chr8124054210-ATAD2chr8124392917-0.0001469270.999853
ENST00000419562ENST00000287394DERL1chr8124054210-ATAD2chr8124392917-0.0001679990.9998319

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Fusion Genomic Features for DERL1-ATAD2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for DERL1-ATAD2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:124054210/chr8:124392917)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDERL1chr8:124054210chr8:124392917ENST00000259512-182_2251252.0Topological domainCytoplasmic
HgeneDERL1chr8:124054210chr8:124392917ENST00000405944-182_2251232.0Topological domainCytoplasmic
HgeneDERL1chr8:124054210chr8:124392917ENST00000259512-1823_4351252.0TransmembraneHelical%3B Name%3D1
HgeneDERL1chr8:124054210chr8:124392917ENST00000405944-1823_4351232.0TransmembraneHelical%3B Name%3D1
TgeneATAD2chr8:124054210chr8:124392917ENST000002873940281086_1112571391.0Coiled coilOntology_term=ECO:0000255
TgeneATAD2chr8:124054210chr8:124392917ENST00000287394028970_994571391.0Coiled coilOntology_term=ECO:0000255
TgeneATAD2chr8:124054210chr8:124392917ENST00000287394028250_285571391.0Compositional biasNote=Asp-rich
TgeneATAD2chr8:124054210chr8:124392917ENST00000287394028357_366571391.0Compositional biasNote=Poly-Ser
TgeneATAD2chr8:124054210chr8:124392917ENST000002873940281001_1071571391.0DomainBromo
TgeneATAD2chr8:124054210chr8:124392917ENST00000287394028467_474571391.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDERL1chr8:124054210chr8:124392917ENST00000259512-18127_15451252.0Topological domainLumenal
HgeneDERL1chr8:124054210chr8:124392917ENST00000259512-18176_25151252.0Topological domainCytoplasmic
HgeneDERL1chr8:124054210chr8:124392917ENST00000259512-1844_5951252.0Topological domainLumenal
HgeneDERL1chr8:124054210chr8:124392917ENST00000259512-1881_10551252.0Topological domainCytoplasmic
HgeneDERL1chr8:124054210chr8:124392917ENST00000405944-18127_15451232.0Topological domainLumenal
HgeneDERL1chr8:124054210chr8:124392917ENST00000405944-18176_25151232.0Topological domainCytoplasmic
HgeneDERL1chr8:124054210chr8:124392917ENST00000405944-1844_5951232.0Topological domainLumenal
HgeneDERL1chr8:124054210chr8:124392917ENST00000405944-1881_10551232.0Topological domainCytoplasmic
HgeneDERL1chr8:124054210chr8:124392917ENST00000259512-18106_12651252.0TransmembraneHelical%3B Name%3D3
HgeneDERL1chr8:124054210chr8:124392917ENST00000259512-18155_17551252.0TransmembraneHelical%3B Name%3D4
HgeneDERL1chr8:124054210chr8:124392917ENST00000259512-1860_8051252.0TransmembraneHelical%3B Name%3D2
HgeneDERL1chr8:124054210chr8:124392917ENST00000405944-18106_12651232.0TransmembraneHelical%3B Name%3D3
HgeneDERL1chr8:124054210chr8:124392917ENST00000405944-18155_17551232.0TransmembraneHelical%3B Name%3D4
HgeneDERL1chr8:124054210chr8:124392917ENST00000405944-1860_8051232.0TransmembraneHelical%3B Name%3D2


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Fusion Gene Sequence for DERL1-ATAD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>22343_22343_1_DERL1-ATAD2_DERL1_chr8_124054210_ENST00000259512_ATAD2_chr8_124392917_ENST00000287394_length(transcript)=5740nt_BP=454nt
ACCTGGCTCCGCCCCCCAGGACGCCGAGCCTCGGCCGGGCGGTAAAATCGGCGCTTACCCTTTAAGCGGCGGGACTTCTGGTCACGTCGT
CCGCGGTCGCCGGAAGGGGAAGTTTCGCCTCAGAAGGCTGCCTCGCTGGTCCGAATTCGGTGGCGCCACGTCCGCCCGTCTCCGCCTTCT
GCATCGCGGCTTCGGCGGCTTCCACCTAGACACCTAACAGTCGCGGAGCCGGCCGCGTCGTGAGGGGGTCGGCACGGGGAGTCGGGCGGT
CTTGTGCATCTTGGCTACCTGTGGGTCGAAGATGTCGGACATCGGAGACTGGTTCAGGAGCATCCCGGCGATCACGCGCTATTGGTTCGC
CGCCACCGTCGCCGTGCCCTTGGTCGGCAAACTCGGCCTCATCAGCCCGGCCTACCTCTTCCTCTGGCCCGAAGCCTTCCTTTATCGCTT
TCAGGATGGGTCATCAGTTAAGGAAGTTGAAACCTACCACCGGACACGTGCTTTAAGATCTTTGAGAAAAGATGCACAGAATTCTTCAGA
TTCTAGTTTTGAGAAGAATGTGGAAATAACGGAGCAACTTGCTAATGGCAGGCATTTTACAAGGCAGTTGGCCAGACAGCAGGCTGATAA
AAAAAAAGAAGAGCACAGAGAAGACAAAGTGATTCCAGTTACTCGGTCATTGAGGGCTAGAAACATCGTTCAAAGTACAGAACACTTACA
TGAAGATAATGGTGATGTTGAAGTGCGTCGAAGTTGTAGGATTAGAAGTCGTTATAGTGGTGTAAACCAGTCCATGCTGTTTGACAAACT
TATAACTAACACTGCTGAAGCTGTACTTCAAAAAATGGATGACATGAAGAAGATGCGTAGACAGCGAATGAGAGAACTTGAAGACTTGGG
AGTGTTTAATGAAACAGAAGAAAGCAATCTTAATATGTACACAAGAGGAAAACAGAAAGATATTCAAAGAACTGATGAAGAAACAACTGA
TAATCAAGAAGGCAGTGTGGAGTCATCTGAAGAGGGTGAAGACCAAGAACATGAAGATGATGGTGAAGATGAAGATGATGAAGATGATGA
TGATGATGACGATGATGATGATGATGATGATGATGAAGATGATGAAGATGAAGAAGATGGAGAAGAAGAGAATCAGAAGCGATATTATCT
TAGACAGAGAAAAGCTACTGTTTACTATCAGGCTCCATTGGAAAAACCTCGTCACCAGAGAAAGCCCAACATATTTTATAGTGGCCCAGC
TTCTCCTGCAAGACCAAGATACCGATTATCTTCCGCAGGACCAAGAAGTCCTTACTGTAAACGAATGAACAGGCGAAGGCATGCAATCCA
CAGTAGTGACTCGACTTCATCTTCCTCCTCTGAAGATGAACAGCACTTTGAGAGGCGGAGGAAAAGGAGTCGTAATAGGGCTATCAATAG
GTGCCTCCCACTAAATTTTCGGAAAGATGAATTAAAAGGCATTTATAAAGATCGAATGAAAATTGGAGCAAGCCTTGCCGATGTTGATCC
AATGCAACTAGATTCTTCAGTACGATTTGATAGTGTTGGTGGCCTGTCTAATCATATAGCAGCTCTAAAAGAGATGGTGGTGTTTCCATT
ACTTTATCCAGAAGTCTTTGAAAAATTTAAAATTCAACCCCCAAGAGGTTGTTTGTTTTATGGGCCACCTGGAACTGGAAAGACTCTGGT
TGCCAGAGCACTTGCCAATGAGTGCAGTCAAGGGGATAAAAGAGTAGCATTTTTCATGAGGAAAGGTGCTGATTGTCTAAGTAAATGGGT
AGGAGAATCTGAAAGACAGCTACGATTGCTGTTTGATCAGGCCTATCAGATGCGCCCATCAATTATTTTTTTTGACGAAATTGATGGTCT
GGCTCCAGTACGGTCAAGCAGGCAAGATCAGATTCACAGTTCTATTGTTTCCACCCTGCTAGCTCTTATGGATGGATTGGACAGCAGAGG
GGAAATTGTGGTCATTGGTGCTACGAACAGGCTAGATTCTATAGATCCTGCTTTACGAAGGCCTGGTCGCTTTGATAGAGAATTCCTCTT
TAGCCTGCCTGATAAAGAGGCTCGAAAAGAGATTCTAAAGATTCACACCAGGGATTGGAATCCCAAACCACTGGACACATTTTTAGAAGA
GCTAGCAGAAAACTGTGTTGGATACTGTGGAGCAGATATTAAATCAATATGTGCTGAAGCTGCTTTATGTGCTTTACGACGACGCTACCC
ACAGATCTATACCACTAGTGAGAAACTGCAGTTGGATCTCTCTTCAATTAATATCTCAGCTAAGGATTTCGAGGTAGCTATGCAAAAGAT
GATACCAGCCTCCCAAAGAGCTGTGACATCACCTGGGCAGGCACTGTCCACCGTTGTGAAACCACTCCTGCAAAACACTGTTGACAAGAT
TTTAGAAGCCCTGCAGAGAGTATTTCCACATGCAGAATTCAGAACAAATAAAACATTAGACTCAGATATTTCTTGTCCTCTGCTAGAAAG
TGACTTGGCTTACAGTGATGATGATGTTCCATCAGTTTATGAAAATGGACTTTCTCAGAAATCTTCTCATAAGGCAAAAGACAATTTTAA
TTTTCTTCATTTGAATAGAAATGCTTGTTACCAACCTATGTCTTTTCGACCAAGAATATTGATAGTAGGAGAACCAGGATTTGGGCAAGG
TTCTCACTTGGCACCAGCTGTCATTCATGCTTTGGAAAAGTTTACTGTATATACATTAGACATTCCTGTTCTTTTTGGAGTTAGTACTAC
ATCCCCTGAAGAAACATGTGCCCAGGTGATTCGTGAAGCTAAGAGAACAGCACCAAGTATAGTGTATGTTCCTCATATCCACGTGTGGTG
GGAAATAGTTGGACCGACACTTAAAGCCACATTTACCACATTATTACAGAATATTCCTTCATTTGCTCCAGTTTTACTACTTGCAACTTC
TGACAAACCCCATTCCGCTTTGCCAGAAGAGGTGCAAGAATTGTTTATCCGTGATTATGGAGAGATTTTTAATGTCCAGTTACCGGATAA
AGAAGAACGGACAAAATTTTTTGAAGATTTAATTCTAAAACAAGCTGCTAAGCCTCCTATATCAAAAAAGAAAGCAGTTTTGCAGGCTTT
GGAGGTACTCCCAGTAGCACCACCACCTGAGCCAAGATCACTGACAGCAGAAGAAGTGAAACGACTAGAAGAACAAGAAGAAGATACATT
TAGAGAACTGAGGATTTTCTTAAGAAATGTTACACATAGGCTTGCTATTGACAAGCGATTCCGAGTGTTTACTAAGCCTGTTGACCCTGA
TGAGGTTCCTGATTATGTCACTGTAATAAAGCAACCAATGGACCTTTCATCTGTAATCAGTAAAATTGATCTACACAAGTATCTGACTGT
GAAAGACTATTTGAGAGATATTGATCTAATCTGTAGTAATGCCTTAGAATACAATCCAGATAGAGATCCTGGAGATCGTCTTATTAGGCA
TAGAGCCTGTGCTTTAAGAGATACTGCCTATGCCATAATTAAAGAAGAACTTGATGAAGACTTTGAGCAGCTCTGTGAAGAAATTCAGGA
ATCTAGAAAGAAAAGAGGTTGTAGCTCCTCCAAATATGCCCCGTCTTACTACCATGTGATGCCAAAGCAAAATTCCACTCTTGTTGGTGA
TAAAAGATCAGACCCAGAGCAGAATGAAAAGCTAAAGACACCGAGTACTCCTGTGGCTTGCAGCACTCCTGCTCAGTTGAAGAGGAAAAT
TCGCAAAAAGTCAAACTGGTACTTAGGCACCATAAAAAAGCGAAGGAAGATTTCACAGGCAAAGGATGATAGCCAGAATGCCATAGATCA
CAAAATTGAGAGTGATACAGAGGAAACTCAAGACACAAGTGTAGATCATAATGAGACCGGAAACACAGGAGAGTCTTCGGTGGAAGAAAA
TGAAAAACAGCAAAATGCCTCTGAAAGCAAACTGGAATTGAGAAATAATTCAAATACTTGTAATATAGAGAATGAGCTTGAAGACTCTAG
GAAGACTACAGCATGTACAGAATTGAGAGACAAGATTGCTTGTAATGGAGATGCTTCTAGCTCTCAGATAATACATATTTCTGATGAAAA
TGAAGGAAAAGAAATGTGTGTTCTGCGAATGACTCGAGCTAGACGTTCCCAGGTAGAACAGCAGCAGCTCATCACTGTTGAAAAGGCTTT
GGCAATTCTTTCTCAGCCTACACCCTCACTTGTTGTGGATCATGAGCGATTAAAAAATCTTTTGAAGACTGTTGTTAAAAAAAGTCAAAA
CTACAACATATTTCAGTTGGAAAATTTGTATGCAGTAATCAGCCAATGTATTTATCGGCATCGCAAGGACCATGATAAAACATCACTTAT
TCAGAAAATGGAGCAAGAGGTAGAAAACTTCAGTTGTTCCAGATGATGATGTCATGGTATCGAGTATTCTTTATATTCAGTTCCTATTTA
AGTCATTTTTGTCATGTCCGCCTAATTGATGTAGTATGAAACCCTGCATCTTTAAGGAAAAGATTAAAATAGTAAAATAAAAGTATTTAA
ACTTTCCTGATATTTATGTACATATTAAGATAAATGTCATGTGTAAGATAACTGATAAATATTGGAACTTTGCTAGAACAAGACCCTGTA
GTAATAGTAATAATAGTTGAAGTTTGGCCAACTCTTAATAAAGTTATTTTGGTAACTAATGTTTTATGGCACTTAAGAATAATTAGCAGC
GTTAAATTTTGTTTGTATTAAGCACTTTTAATTTTATCCTTCCTAAAAATAGTTTATTGTATCTGACAAGAAACTTACTTAACCATTGTG
TCCTTCCCATCTTTTTTGTCATCTTTGTTTTCTTCAAATGCCCTCCTCCCATCTGCCTTGAGATTCCCTCGTCTTCACTTAAAAGCCAGA
GTGCAAGTCATGATTTGCGGGAGGGCTCTTGAACCACTTCTGGCTGCACCACAATTCTGTACTTGAGTATCACAGTCATTGTTTTTGAGA
CAAACATTTTTATAATTCTAATTTGGGTTAATAAAGATTTTAAATATTTCTTGGTTTACTTTTGTAATTATATACACAACAAATGTATTA
ATAACTACCTTGTTAAACACCTTTTAATAGCACAAGGTTTTTATATTTGCAAGCTGTTGATATCTTTCTAAAACTGTTTAGGTTATAGTC
TATTGATACTTTTTATATACAATTTTATAAATATAAATATTATAATTTTATATTAATGGTACCAAAAATACATTTCTTAAGGTTAAAAGC
ATGCACTTCCATGCATACTTGCTTTTGGGGAGAGTGGGGAGAAGACATTCTAATAATCAGTTTGTGAAATAGCTTCTGTTGGAAACCTTT
TGAGGGGAATAAGGAATGGTCATCTAAAATGAGAGATTCTGGATTTTAATGCAGTTCAAAGTTGAGCTGTATTTTTGTTGTTGATTTATC
TGGATTTTTTTTAAAGCCTTCTAAAACCCAGTGAATTCAATACCTTAATTAGTACATACTATCTTATGTAATGCATAAAGCAATGCCAGT
CACTGAGAACATTTAAATATATTTATATTCCTGGAGATACACATTCTCATTTTTGTTGGTTTATTATAAATTATTCTTCTAGATGCATCT

>22343_22343_1_DERL1-ATAD2_DERL1_chr8_124054210_ENST00000259512_ATAD2_chr8_124392917_ENST00000287394_length(amino acids)=1394AA_BP=61
MCILATCGSKMSDIGDWFRSIPAITRYWFAATVAVPLVGKLGLISPAYLFLWPEAFLYRFQDGSSVKEVETYHRTRALRSLRKDAQNSSD
SSFEKNVEITEQLANGRHFTRQLARQQADKKKEEHREDKVIPVTRSLRARNIVQSTEHLHEDNGDVEVRRSCRIRSRYSGVNQSMLFDKL
ITNTAEAVLQKMDDMKKMRRQRMRELEDLGVFNETEESNLNMYTRGKQKDIQRTDEETTDNQEGSVESSEEGEDQEHEDDGEDEDDEDDD
DDDDDDDDDDDEDDEDEEDGEEENQKRYYLRQRKATVYYQAPLEKPRHQRKPNIFYSGPASPARPRYRLSSAGPRSPYCKRMNRRRHAIH
SSDSTSSSSSEDEQHFERRRKRSRNRAINRCLPLNFRKDELKGIYKDRMKIGASLADVDPMQLDSSVRFDSVGGLSNHIAALKEMVVFPL
LYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGL
APVRSSRQDQIHSSIVSTLLALMDGLDSRGEIVVIGATNRLDSIDPALRRPGRFDREFLFSLPDKEARKEILKIHTRDWNPKPLDTFLEE
LAENCVGYCGADIKSICAEAALCALRRRYPQIYTTSEKLQLDLSSINISAKDFEVAMQKMIPASQRAVTSPGQALSTVVKPLLQNTVDKI
LEALQRVFPHAEFRTNKTLDSDISCPLLESDLAYSDDDVPSVYENGLSQKSSHKAKDNFNFLHLNRNACYQPMSFRPRILIVGEPGFGQG
SHLAPAVIHALEKFTVYTLDIPVLFGVSTTSPEETCAQVIREAKRTAPSIVYVPHIHVWWEIVGPTLKATFTTLLQNIPSFAPVLLLATS
DKPHSALPEEVQELFIRDYGEIFNVQLPDKEERTKFFEDLILKQAAKPPISKKKAVLQALEVLPVAPPPEPRSLTAEEVKRLEEQEEDTF
RELRIFLRNVTHRLAIDKRFRVFTKPVDPDEVPDYVTVIKQPMDLSSVISKIDLHKYLTVKDYLRDIDLICSNALEYNPDRDPGDRLIRH
RACALRDTAYAIIKEELDEDFEQLCEEIQESRKKRGCSSSKYAPSYYHVMPKQNSTLVGDKRSDPEQNEKLKTPSTPVACSTPAQLKRKI
RKKSNWYLGTIKKRRKISQAKDDSQNAIDHKIESDTEETQDTSVDHNETGNTGESSVEENEKQQNASESKLELRNNSNTCNIENELEDSR
KTTACTELRDKIACNGDASSSQIIHISDENEGKEMCVLRMTRARRSQVEQQQLITVEKALAILSQPTPSLVVDHERLKNLLKTVVKKSQN

--------------------------------------------------------------
>22343_22343_2_DERL1-ATAD2_DERL1_chr8_124054210_ENST00000405944_ATAD2_chr8_124392917_ENST00000287394_length(transcript)=5439nt_BP=153nt
ATGTCGGACATCGGAGACTGGTTCAGGAGCATCCCGGCGATCACGCGCTATTGGTTCGCCGCCACCGTCGCCGTGCCCTTGGTCGGCAAA
CTCGGCCTCATCAGCCCGGCCTACCTCTTCCTCTGGCCCGAAGCCTTCCTTTATCGCTTTCAGGATGGGTCATCAGTTAAGGAAGTTGAA
ACCTACCACCGGACACGTGCTTTAAGATCTTTGAGAAAAGATGCACAGAATTCTTCAGATTCTAGTTTTGAGAAGAATGTGGAAATAACG
GAGCAACTTGCTAATGGCAGGCATTTTACAAGGCAGTTGGCCAGACAGCAGGCTGATAAAAAAAAAGAAGAGCACAGAGAAGACAAAGTG
ATTCCAGTTACTCGGTCATTGAGGGCTAGAAACATCGTTCAAAGTACAGAACACTTACATGAAGATAATGGTGATGTTGAAGTGCGTCGA
AGTTGTAGGATTAGAAGTCGTTATAGTGGTGTAAACCAGTCCATGCTGTTTGACAAACTTATAACTAACACTGCTGAAGCTGTACTTCAA
AAAATGGATGACATGAAGAAGATGCGTAGACAGCGAATGAGAGAACTTGAAGACTTGGGAGTGTTTAATGAAACAGAAGAAAGCAATCTT
AATATGTACACAAGAGGAAAACAGAAAGATATTCAAAGAACTGATGAAGAAACAACTGATAATCAAGAAGGCAGTGTGGAGTCATCTGAA
GAGGGTGAAGACCAAGAACATGAAGATGATGGTGAAGATGAAGATGATGAAGATGATGATGATGATGACGATGATGATGATGATGATGAT
GATGAAGATGATGAAGATGAAGAAGATGGAGAAGAAGAGAATCAGAAGCGATATTATCTTAGACAGAGAAAAGCTACTGTTTACTATCAG
GCTCCATTGGAAAAACCTCGTCACCAGAGAAAGCCCAACATATTTTATAGTGGCCCAGCTTCTCCTGCAAGACCAAGATACCGATTATCT
TCCGCAGGACCAAGAAGTCCTTACTGTAAACGAATGAACAGGCGAAGGCATGCAATCCACAGTAGTGACTCGACTTCATCTTCCTCCTCT
GAAGATGAACAGCACTTTGAGAGGCGGAGGAAAAGGAGTCGTAATAGGGCTATCAATAGGTGCCTCCCACTAAATTTTCGGAAAGATGAA
TTAAAAGGCATTTATAAAGATCGAATGAAAATTGGAGCAAGCCTTGCCGATGTTGATCCAATGCAACTAGATTCTTCAGTACGATTTGAT
AGTGTTGGTGGCCTGTCTAATCATATAGCAGCTCTAAAAGAGATGGTGGTGTTTCCATTACTTTATCCAGAAGTCTTTGAAAAATTTAAA
ATTCAACCCCCAAGAGGTTGTTTGTTTTATGGGCCACCTGGAACTGGAAAGACTCTGGTTGCCAGAGCACTTGCCAATGAGTGCAGTCAA
GGGGATAAAAGAGTAGCATTTTTCATGAGGAAAGGTGCTGATTGTCTAAGTAAATGGGTAGGAGAATCTGAAAGACAGCTACGATTGCTG
TTTGATCAGGCCTATCAGATGCGCCCATCAATTATTTTTTTTGACGAAATTGATGGTCTGGCTCCAGTACGGTCAAGCAGGCAAGATCAG
ATTCACAGTTCTATTGTTTCCACCCTGCTAGCTCTTATGGATGGATTGGACAGCAGAGGGGAAATTGTGGTCATTGGTGCTACGAACAGG
CTAGATTCTATAGATCCTGCTTTACGAAGGCCTGGTCGCTTTGATAGAGAATTCCTCTTTAGCCTGCCTGATAAAGAGGCTCGAAAAGAG
ATTCTAAAGATTCACACCAGGGATTGGAATCCCAAACCACTGGACACATTTTTAGAAGAGCTAGCAGAAAACTGTGTTGGATACTGTGGA
GCAGATATTAAATCAATATGTGCTGAAGCTGCTTTATGTGCTTTACGACGACGCTACCCACAGATCTATACCACTAGTGAGAAACTGCAG
TTGGATCTCTCTTCAATTAATATCTCAGCTAAGGATTTCGAGGTAGCTATGCAAAAGATGATACCAGCCTCCCAAAGAGCTGTGACATCA
CCTGGGCAGGCACTGTCCACCGTTGTGAAACCACTCCTGCAAAACACTGTTGACAAGATTTTAGAAGCCCTGCAGAGAGTATTTCCACAT
GCAGAATTCAGAACAAATAAAACATTAGACTCAGATATTTCTTGTCCTCTGCTAGAAAGTGACTTGGCTTACAGTGATGATGATGTTCCA
TCAGTTTATGAAAATGGACTTTCTCAGAAATCTTCTCATAAGGCAAAAGACAATTTTAATTTTCTTCATTTGAATAGAAATGCTTGTTAC
CAACCTATGTCTTTTCGACCAAGAATATTGATAGTAGGAGAACCAGGATTTGGGCAAGGTTCTCACTTGGCACCAGCTGTCATTCATGCT
TTGGAAAAGTTTACTGTATATACATTAGACATTCCTGTTCTTTTTGGAGTTAGTACTACATCCCCTGAAGAAACATGTGCCCAGGTGATT
CGTGAAGCTAAGAGAACAGCACCAAGTATAGTGTATGTTCCTCATATCCACGTGTGGTGGGAAATAGTTGGACCGACACTTAAAGCCACA
TTTACCACATTATTACAGAATATTCCTTCATTTGCTCCAGTTTTACTACTTGCAACTTCTGACAAACCCCATTCCGCTTTGCCAGAAGAG
GTGCAAGAATTGTTTATCCGTGATTATGGAGAGATTTTTAATGTCCAGTTACCGGATAAAGAAGAACGGACAAAATTTTTTGAAGATTTA
ATTCTAAAACAAGCTGCTAAGCCTCCTATATCAAAAAAGAAAGCAGTTTTGCAGGCTTTGGAGGTACTCCCAGTAGCACCACCACCTGAG
CCAAGATCACTGACAGCAGAAGAAGTGAAACGACTAGAAGAACAAGAAGAAGATACATTTAGAGAACTGAGGATTTTCTTAAGAAATGTT
ACACATAGGCTTGCTATTGACAAGCGATTCCGAGTGTTTACTAAGCCTGTTGACCCTGATGAGGTTCCTGATTATGTCACTGTAATAAAG
CAACCAATGGACCTTTCATCTGTAATCAGTAAAATTGATCTACACAAGTATCTGACTGTGAAAGACTATTTGAGAGATATTGATCTAATC
TGTAGTAATGCCTTAGAATACAATCCAGATAGAGATCCTGGAGATCGTCTTATTAGGCATAGAGCCTGTGCTTTAAGAGATACTGCCTAT
GCCATAATTAAAGAAGAACTTGATGAAGACTTTGAGCAGCTCTGTGAAGAAATTCAGGAATCTAGAAAGAAAAGAGGTTGTAGCTCCTCC
AAATATGCCCCGTCTTACTACCATGTGATGCCAAAGCAAAATTCCACTCTTGTTGGTGATAAAAGATCAGACCCAGAGCAGAATGAAAAG
CTAAAGACACCGAGTACTCCTGTGGCTTGCAGCACTCCTGCTCAGTTGAAGAGGAAAATTCGCAAAAAGTCAAACTGGTACTTAGGCACC
ATAAAAAAGCGAAGGAAGATTTCACAGGCAAAGGATGATAGCCAGAATGCCATAGATCACAAAATTGAGAGTGATACAGAGGAAACTCAA
GACACAAGTGTAGATCATAATGAGACCGGAAACACAGGAGAGTCTTCGGTGGAAGAAAATGAAAAACAGCAAAATGCCTCTGAAAGCAAA
CTGGAATTGAGAAATAATTCAAATACTTGTAATATAGAGAATGAGCTTGAAGACTCTAGGAAGACTACAGCATGTACAGAATTGAGAGAC
AAGATTGCTTGTAATGGAGATGCTTCTAGCTCTCAGATAATACATATTTCTGATGAAAATGAAGGAAAAGAAATGTGTGTTCTGCGAATG
ACTCGAGCTAGACGTTCCCAGGTAGAACAGCAGCAGCTCATCACTGTTGAAAAGGCTTTGGCAATTCTTTCTCAGCCTACACCCTCACTT
GTTGTGGATCATGAGCGATTAAAAAATCTTTTGAAGACTGTTGTTAAAAAAAGTCAAAACTACAACATATTTCAGTTGGAAAATTTGTAT
GCAGTAATCAGCCAATGTATTTATCGGCATCGCAAGGACCATGATAAAACATCACTTATTCAGAAAATGGAGCAAGAGGTAGAAAACTTC
AGTTGTTCCAGATGATGATGTCATGGTATCGAGTATTCTTTATATTCAGTTCCTATTTAAGTCATTTTTGTCATGTCCGCCTAATTGATG
TAGTATGAAACCCTGCATCTTTAAGGAAAAGATTAAAATAGTAAAATAAAAGTATTTAAACTTTCCTGATATTTATGTACATATTAAGAT
AAATGTCATGTGTAAGATAACTGATAAATATTGGAACTTTGCTAGAACAAGACCCTGTAGTAATAGTAATAATAGTTGAAGTTTGGCCAA
CTCTTAATAAAGTTATTTTGGTAACTAATGTTTTATGGCACTTAAGAATAATTAGCAGCGTTAAATTTTGTTTGTATTAAGCACTTTTAA
TTTTATCCTTCCTAAAAATAGTTTATTGTATCTGACAAGAAACTTACTTAACCATTGTGTCCTTCCCATCTTTTTTGTCATCTTTGTTTT
CTTCAAATGCCCTCCTCCCATCTGCCTTGAGATTCCCTCGTCTTCACTTAAAAGCCAGAGTGCAAGTCATGATTTGCGGGAGGGCTCTTG
AACCACTTCTGGCTGCACCACAATTCTGTACTTGAGTATCACAGTCATTGTTTTTGAGACAAACATTTTTATAATTCTAATTTGGGTTAA
TAAAGATTTTAAATATTTCTTGGTTTACTTTTGTAATTATATACACAACAAATGTATTAATAACTACCTTGTTAAACACCTTTTAATAGC
ACAAGGTTTTTATATTTGCAAGCTGTTGATATCTTTCTAAAACTGTTTAGGTTATAGTCTATTGATACTTTTTATATACAATTTTATAAA
TATAAATATTATAATTTTATATTAATGGTACCAAAAATACATTTCTTAAGGTTAAAAGCATGCACTTCCATGCATACTTGCTTTTGGGGA
GAGTGGGGAGAAGACATTCTAATAATCAGTTTGTGAAATAGCTTCTGTTGGAAACCTTTTGAGGGGAATAAGGAATGGTCATCTAAAATG
AGAGATTCTGGATTTTAATGCAGTTCAAAGTTGAGCTGTATTTTTGTTGTTGATTTATCTGGATTTTTTTTAAAGCCTTCTAAAACCCAG
TGAATTCAATACCTTAATTAGTACATACTATCTTATGTAATGCATAAAGCAATGCCAGTCACTGAGAACATTTAAATATATTTATATTCC
TGGAGATACACATTCTCATTTTTGTTGGTTTATTATAAATTATTCTTCTAGATGCATCTTTTATAACTAGGATTTCATTTTGTGTGTATA

>22343_22343_2_DERL1-ATAD2_DERL1_chr8_124054210_ENST00000405944_ATAD2_chr8_124392917_ENST00000287394_length(amino acids)=1384AA_BP=51
MSDIGDWFRSIPAITRYWFAATVAVPLVGKLGLISPAYLFLWPEAFLYRFQDGSSVKEVETYHRTRALRSLRKDAQNSSDSSFEKNVEIT
EQLANGRHFTRQLARQQADKKKEEHREDKVIPVTRSLRARNIVQSTEHLHEDNGDVEVRRSCRIRSRYSGVNQSMLFDKLITNTAEAVLQ
KMDDMKKMRRQRMRELEDLGVFNETEESNLNMYTRGKQKDIQRTDEETTDNQEGSVESSEEGEDQEHEDDGEDEDDEDDDDDDDDDDDDD
DEDDEDEEDGEEENQKRYYLRQRKATVYYQAPLEKPRHQRKPNIFYSGPASPARPRYRLSSAGPRSPYCKRMNRRRHAIHSSDSTSSSSS
EDEQHFERRRKRSRNRAINRCLPLNFRKDELKGIYKDRMKIGASLADVDPMQLDSSVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFK
IQPPRGCLFYGPPGTGKTLVARALANECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVRSSRQDQ
IHSSIVSTLLALMDGLDSRGEIVVIGATNRLDSIDPALRRPGRFDREFLFSLPDKEARKEILKIHTRDWNPKPLDTFLEELAENCVGYCG
ADIKSICAEAALCALRRRYPQIYTTSEKLQLDLSSINISAKDFEVAMQKMIPASQRAVTSPGQALSTVVKPLLQNTVDKILEALQRVFPH
AEFRTNKTLDSDISCPLLESDLAYSDDDVPSVYENGLSQKSSHKAKDNFNFLHLNRNACYQPMSFRPRILIVGEPGFGQGSHLAPAVIHA
LEKFTVYTLDIPVLFGVSTTSPEETCAQVIREAKRTAPSIVYVPHIHVWWEIVGPTLKATFTTLLQNIPSFAPVLLLATSDKPHSALPEE
VQELFIRDYGEIFNVQLPDKEERTKFFEDLILKQAAKPPISKKKAVLQALEVLPVAPPPEPRSLTAEEVKRLEEQEEDTFRELRIFLRNV
THRLAIDKRFRVFTKPVDPDEVPDYVTVIKQPMDLSSVISKIDLHKYLTVKDYLRDIDLICSNALEYNPDRDPGDRLIRHRACALRDTAY
AIIKEELDEDFEQLCEEIQESRKKRGCSSSKYAPSYYHVMPKQNSTLVGDKRSDPEQNEKLKTPSTPVACSTPAQLKRKIRKKSNWYLGT
IKKRRKISQAKDDSQNAIDHKIESDTEETQDTSVDHNETGNTGESSVEENEKQQNASESKLELRNNSNTCNIENELEDSRKTTACTELRD
KIACNGDASSSQIIHISDENEGKEMCVLRMTRARRSQVEQQQLITVEKALAILSQPTPSLVVDHERLKNLLKTVVKKSQNYNIFQLENLY

--------------------------------------------------------------
>22343_22343_3_DERL1-ATAD2_DERL1_chr8_124054210_ENST00000419562_ATAD2_chr8_124392917_ENST00000287394_length(transcript)=5619nt_BP=333nt
AGAAGGCTGCCTCGCTGGTCCGAATTCGGTGGCGCCACGTCCGCCCGTCTCCGCCTTCTGCATCGCGGCTTCGGCGGCTTCCACCTAGAC
ACCTAACAGTCGCGGAGCCGGCCGCGTCGTGAGGGGGTCGGCACGGGGAGTCGGGCGGTCTTGTGCATCTTGGCTACCTGTGGGTCGAAG
ATGTCGGACATCGGAGACTGGTTCAGGAGCATCCCGGCGATCACGCGCTATTGGTTCGCCGCCACCGTCGCCGTGCCCTTGGTCGGCAAA
CTCGGCCTCATCAGCCCGGCCTACCTCTTCCTCTGGCCCGAAGCCTTCCTTTATCGCTTTCAGGATGGGTCATCAGTTAAGGAAGTTGAA
ACCTACCACCGGACACGTGCTTTAAGATCTTTGAGAAAAGATGCACAGAATTCTTCAGATTCTAGTTTTGAGAAGAATGTGGAAATAACG
GAGCAACTTGCTAATGGCAGGCATTTTACAAGGCAGTTGGCCAGACAGCAGGCTGATAAAAAAAAAGAAGAGCACAGAGAAGACAAAGTG
ATTCCAGTTACTCGGTCATTGAGGGCTAGAAACATCGTTCAAAGTACAGAACACTTACATGAAGATAATGGTGATGTTGAAGTGCGTCGA
AGTTGTAGGATTAGAAGTCGTTATAGTGGTGTAAACCAGTCCATGCTGTTTGACAAACTTATAACTAACACTGCTGAAGCTGTACTTCAA
AAAATGGATGACATGAAGAAGATGCGTAGACAGCGAATGAGAGAACTTGAAGACTTGGGAGTGTTTAATGAAACAGAAGAAAGCAATCTT
AATATGTACACAAGAGGAAAACAGAAAGATATTCAAAGAACTGATGAAGAAACAACTGATAATCAAGAAGGCAGTGTGGAGTCATCTGAA
GAGGGTGAAGACCAAGAACATGAAGATGATGGTGAAGATGAAGATGATGAAGATGATGATGATGATGACGATGATGATGATGATGATGAT
GATGAAGATGATGAAGATGAAGAAGATGGAGAAGAAGAGAATCAGAAGCGATATTATCTTAGACAGAGAAAAGCTACTGTTTACTATCAG
GCTCCATTGGAAAAACCTCGTCACCAGAGAAAGCCCAACATATTTTATAGTGGCCCAGCTTCTCCTGCAAGACCAAGATACCGATTATCT
TCCGCAGGACCAAGAAGTCCTTACTGTAAACGAATGAACAGGCGAAGGCATGCAATCCACAGTAGTGACTCGACTTCATCTTCCTCCTCT
GAAGATGAACAGCACTTTGAGAGGCGGAGGAAAAGGAGTCGTAATAGGGCTATCAATAGGTGCCTCCCACTAAATTTTCGGAAAGATGAA
TTAAAAGGCATTTATAAAGATCGAATGAAAATTGGAGCAAGCCTTGCCGATGTTGATCCAATGCAACTAGATTCTTCAGTACGATTTGAT
AGTGTTGGTGGCCTGTCTAATCATATAGCAGCTCTAAAAGAGATGGTGGTGTTTCCATTACTTTATCCAGAAGTCTTTGAAAAATTTAAA
ATTCAACCCCCAAGAGGTTGTTTGTTTTATGGGCCACCTGGAACTGGAAAGACTCTGGTTGCCAGAGCACTTGCCAATGAGTGCAGTCAA
GGGGATAAAAGAGTAGCATTTTTCATGAGGAAAGGTGCTGATTGTCTAAGTAAATGGGTAGGAGAATCTGAAAGACAGCTACGATTGCTG
TTTGATCAGGCCTATCAGATGCGCCCATCAATTATTTTTTTTGACGAAATTGATGGTCTGGCTCCAGTACGGTCAAGCAGGCAAGATCAG
ATTCACAGTTCTATTGTTTCCACCCTGCTAGCTCTTATGGATGGATTGGACAGCAGAGGGGAAATTGTGGTCATTGGTGCTACGAACAGG
CTAGATTCTATAGATCCTGCTTTACGAAGGCCTGGTCGCTTTGATAGAGAATTCCTCTTTAGCCTGCCTGATAAAGAGGCTCGAAAAGAG
ATTCTAAAGATTCACACCAGGGATTGGAATCCCAAACCACTGGACACATTTTTAGAAGAGCTAGCAGAAAACTGTGTTGGATACTGTGGA
GCAGATATTAAATCAATATGTGCTGAAGCTGCTTTATGTGCTTTACGACGACGCTACCCACAGATCTATACCACTAGTGAGAAACTGCAG
TTGGATCTCTCTTCAATTAATATCTCAGCTAAGGATTTCGAGGTAGCTATGCAAAAGATGATACCAGCCTCCCAAAGAGCTGTGACATCA
CCTGGGCAGGCACTGTCCACCGTTGTGAAACCACTCCTGCAAAACACTGTTGACAAGATTTTAGAAGCCCTGCAGAGAGTATTTCCACAT
GCAGAATTCAGAACAAATAAAACATTAGACTCAGATATTTCTTGTCCTCTGCTAGAAAGTGACTTGGCTTACAGTGATGATGATGTTCCA
TCAGTTTATGAAAATGGACTTTCTCAGAAATCTTCTCATAAGGCAAAAGACAATTTTAATTTTCTTCATTTGAATAGAAATGCTTGTTAC
CAACCTATGTCTTTTCGACCAAGAATATTGATAGTAGGAGAACCAGGATTTGGGCAAGGTTCTCACTTGGCACCAGCTGTCATTCATGCT
TTGGAAAAGTTTACTGTATATACATTAGACATTCCTGTTCTTTTTGGAGTTAGTACTACATCCCCTGAAGAAACATGTGCCCAGGTGATT
CGTGAAGCTAAGAGAACAGCACCAAGTATAGTGTATGTTCCTCATATCCACGTGTGGTGGGAAATAGTTGGACCGACACTTAAAGCCACA
TTTACCACATTATTACAGAATATTCCTTCATTTGCTCCAGTTTTACTACTTGCAACTTCTGACAAACCCCATTCCGCTTTGCCAGAAGAG
GTGCAAGAATTGTTTATCCGTGATTATGGAGAGATTTTTAATGTCCAGTTACCGGATAAAGAAGAACGGACAAAATTTTTTGAAGATTTA
ATTCTAAAACAAGCTGCTAAGCCTCCTATATCAAAAAAGAAAGCAGTTTTGCAGGCTTTGGAGGTACTCCCAGTAGCACCACCACCTGAG
CCAAGATCACTGACAGCAGAAGAAGTGAAACGACTAGAAGAACAAGAAGAAGATACATTTAGAGAACTGAGGATTTTCTTAAGAAATGTT
ACACATAGGCTTGCTATTGACAAGCGATTCCGAGTGTTTACTAAGCCTGTTGACCCTGATGAGGTTCCTGATTATGTCACTGTAATAAAG
CAACCAATGGACCTTTCATCTGTAATCAGTAAAATTGATCTACACAAGTATCTGACTGTGAAAGACTATTTGAGAGATATTGATCTAATC
TGTAGTAATGCCTTAGAATACAATCCAGATAGAGATCCTGGAGATCGTCTTATTAGGCATAGAGCCTGTGCTTTAAGAGATACTGCCTAT
GCCATAATTAAAGAAGAACTTGATGAAGACTTTGAGCAGCTCTGTGAAGAAATTCAGGAATCTAGAAAGAAAAGAGGTTGTAGCTCCTCC
AAATATGCCCCGTCTTACTACCATGTGATGCCAAAGCAAAATTCCACTCTTGTTGGTGATAAAAGATCAGACCCAGAGCAGAATGAAAAG
CTAAAGACACCGAGTACTCCTGTGGCTTGCAGCACTCCTGCTCAGTTGAAGAGGAAAATTCGCAAAAAGTCAAACTGGTACTTAGGCACC
ATAAAAAAGCGAAGGAAGATTTCACAGGCAAAGGATGATAGCCAGAATGCCATAGATCACAAAATTGAGAGTGATACAGAGGAAACTCAA
GACACAAGTGTAGATCATAATGAGACCGGAAACACAGGAGAGTCTTCGGTGGAAGAAAATGAAAAACAGCAAAATGCCTCTGAAAGCAAA
CTGGAATTGAGAAATAATTCAAATACTTGTAATATAGAGAATGAGCTTGAAGACTCTAGGAAGACTACAGCATGTACAGAATTGAGAGAC
AAGATTGCTTGTAATGGAGATGCTTCTAGCTCTCAGATAATACATATTTCTGATGAAAATGAAGGAAAAGAAATGTGTGTTCTGCGAATG
ACTCGAGCTAGACGTTCCCAGGTAGAACAGCAGCAGCTCATCACTGTTGAAAAGGCTTTGGCAATTCTTTCTCAGCCTACACCCTCACTT
GTTGTGGATCATGAGCGATTAAAAAATCTTTTGAAGACTGTTGTTAAAAAAAGTCAAAACTACAACATATTTCAGTTGGAAAATTTGTAT
GCAGTAATCAGCCAATGTATTTATCGGCATCGCAAGGACCATGATAAAACATCACTTATTCAGAAAATGGAGCAAGAGGTAGAAAACTTC
AGTTGTTCCAGATGATGATGTCATGGTATCGAGTATTCTTTATATTCAGTTCCTATTTAAGTCATTTTTGTCATGTCCGCCTAATTGATG
TAGTATGAAACCCTGCATCTTTAAGGAAAAGATTAAAATAGTAAAATAAAAGTATTTAAACTTTCCTGATATTTATGTACATATTAAGAT
AAATGTCATGTGTAAGATAACTGATAAATATTGGAACTTTGCTAGAACAAGACCCTGTAGTAATAGTAATAATAGTTGAAGTTTGGCCAA
CTCTTAATAAAGTTATTTTGGTAACTAATGTTTTATGGCACTTAAGAATAATTAGCAGCGTTAAATTTTGTTTGTATTAAGCACTTTTAA
TTTTATCCTTCCTAAAAATAGTTTATTGTATCTGACAAGAAACTTACTTAACCATTGTGTCCTTCCCATCTTTTTTGTCATCTTTGTTTT
CTTCAAATGCCCTCCTCCCATCTGCCTTGAGATTCCCTCGTCTTCACTTAAAAGCCAGAGTGCAAGTCATGATTTGCGGGAGGGCTCTTG
AACCACTTCTGGCTGCACCACAATTCTGTACTTGAGTATCACAGTCATTGTTTTTGAGACAAACATTTTTATAATTCTAATTTGGGTTAA
TAAAGATTTTAAATATTTCTTGGTTTACTTTTGTAATTATATACACAACAAATGTATTAATAACTACCTTGTTAAACACCTTTTAATAGC
ACAAGGTTTTTATATTTGCAAGCTGTTGATATCTTTCTAAAACTGTTTAGGTTATAGTCTATTGATACTTTTTATATACAATTTTATAAA
TATAAATATTATAATTTTATATTAATGGTACCAAAAATACATTTCTTAAGGTTAAAAGCATGCACTTCCATGCATACTTGCTTTTGGGGA
GAGTGGGGAGAAGACATTCTAATAATCAGTTTGTGAAATAGCTTCTGTTGGAAACCTTTTGAGGGGAATAAGGAATGGTCATCTAAAATG
AGAGATTCTGGATTTTAATGCAGTTCAAAGTTGAGCTGTATTTTTGTTGTTGATTTATCTGGATTTTTTTTAAAGCCTTCTAAAACCCAG
TGAATTCAATACCTTAATTAGTACATACTATCTTATGTAATGCATAAAGCAATGCCAGTCACTGAGAACATTTAAATATATTTATATTCC
TGGAGATACACATTCTCATTTTTGTTGGTTTATTATAAATTATTCTTCTAGATGCATCTTTTATAACTAGGATTTCATTTTGTGTGTATA

>22343_22343_3_DERL1-ATAD2_DERL1_chr8_124054210_ENST00000419562_ATAD2_chr8_124392917_ENST00000287394_length(amino acids)=1394AA_BP=61
MCILATCGSKMSDIGDWFRSIPAITRYWFAATVAVPLVGKLGLISPAYLFLWPEAFLYRFQDGSSVKEVETYHRTRALRSLRKDAQNSSD
SSFEKNVEITEQLANGRHFTRQLARQQADKKKEEHREDKVIPVTRSLRARNIVQSTEHLHEDNGDVEVRRSCRIRSRYSGVNQSMLFDKL
ITNTAEAVLQKMDDMKKMRRQRMRELEDLGVFNETEESNLNMYTRGKQKDIQRTDEETTDNQEGSVESSEEGEDQEHEDDGEDEDDEDDD
DDDDDDDDDDDEDDEDEEDGEEENQKRYYLRQRKATVYYQAPLEKPRHQRKPNIFYSGPASPARPRYRLSSAGPRSPYCKRMNRRRHAIH
SSDSTSSSSSEDEQHFERRRKRSRNRAINRCLPLNFRKDELKGIYKDRMKIGASLADVDPMQLDSSVRFDSVGGLSNHIAALKEMVVFPL
LYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGL
APVRSSRQDQIHSSIVSTLLALMDGLDSRGEIVVIGATNRLDSIDPALRRPGRFDREFLFSLPDKEARKEILKIHTRDWNPKPLDTFLEE
LAENCVGYCGADIKSICAEAALCALRRRYPQIYTTSEKLQLDLSSINISAKDFEVAMQKMIPASQRAVTSPGQALSTVVKPLLQNTVDKI
LEALQRVFPHAEFRTNKTLDSDISCPLLESDLAYSDDDVPSVYENGLSQKSSHKAKDNFNFLHLNRNACYQPMSFRPRILIVGEPGFGQG
SHLAPAVIHALEKFTVYTLDIPVLFGVSTTSPEETCAQVIREAKRTAPSIVYVPHIHVWWEIVGPTLKATFTTLLQNIPSFAPVLLLATS
DKPHSALPEEVQELFIRDYGEIFNVQLPDKEERTKFFEDLILKQAAKPPISKKKAVLQALEVLPVAPPPEPRSLTAEEVKRLEEQEEDTF
RELRIFLRNVTHRLAIDKRFRVFTKPVDPDEVPDYVTVIKQPMDLSSVISKIDLHKYLTVKDYLRDIDLICSNALEYNPDRDPGDRLIRH
RACALRDTAYAIIKEELDEDFEQLCEEIQESRKKRGCSSSKYAPSYYHVMPKQNSTLVGDKRSDPEQNEKLKTPSTPVACSTPAQLKRKI
RKKSNWYLGTIKKRRKISQAKDDSQNAIDHKIESDTEETQDTSVDHNETGNTGESSVEENEKQQNASESKLELRNNSNTCNIENELEDSR
KTTACTELRDKIACNGDASSSQIIHISDENEGKEMCVLRMTRARRSQVEQQQLITVEKALAILSQPTPSLVVDHERLKNLLKTVVKKSQN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DERL1-ATAD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DERL1-ATAD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DERL1-ATAD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDERL1C0014518Toxic Epidermal Necrolysis1CTD_human
HgeneDERL1C0038325Stevens-Johnson Syndrome1CTD_human
HgeneDERL1C1274933Drug-Induced Stevens Johnson Syndrome1CTD_human
HgeneDERL1C3658301Mycoplasma-Induced Stevens-Johnson Syndrome1CTD_human
HgeneDERL1C3658302Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum1CTD_human