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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:DEK-NR1D2 (FusionGDB2 ID:HG7913TG9975) |
Fusion Gene Summary for DEK-NR1D2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DEK-NR1D2 | Fusion gene ID: hg7913tg9975 | Hgene | Tgene | Gene symbol | DEK | NR1D2 | Gene ID | 7913 | 9975 |
| Gene name | DEK proto-oncogene | nuclear receptor subfamily 1 group D member 2 | |
| Synonyms | D6S231E | BD73|EAR-1R|REVERBB|REVERBbeta|RVR | |
| Cytomap | ('DEK')('NR1D2') 6p22.3 | 3p24.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein DEKDEK oncogene (DNA binding) | nuclear receptor subfamily 1 group D member 2V-erbA-related protein 1-relatednuclear receptor Rev-ErbA beta variant 1nuclear receptor Rev-ErbA beta variant 2orphan nuclear hormone receptor BD73rev-erb alpha-related receptorrev-erb-betarev-erba-alph | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | P35659 | Q14995 | |
| Ensembl transtripts involved in fusion gene | ENST00000244776, ENST00000397239, | ||
| Fusion gene scores | * DoF score | 11 X 13 X 6=858 | 4 X 4 X 4=64 |
| # samples | 15 | 4 | |
| ** MAII score | log2(15/858*10)=-2.51601514700366 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DEK [Title/Abstract] AND NR1D2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | DEK(18236682)-NR1D2(24018713), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | DEK-NR1D2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DEK-NR1D2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DEK-NR1D2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. DEK-NR1D2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NR1D2 | GO:0045892 | negative regulation of transcription, DNA-templated | 17892483|17996965 |
| Fusion gene breakpoints across DEK (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across NR1D2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | Non-Cancer | 265N | DEK | chr6 | 18236682 | - | NR1D2 | chr3 | 24018713 | + |
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Fusion Gene ORF analysis for DEK-NR1D2 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000244776 | ENST00000492552 | DEK | chr6 | 18236682 | - | NR1D2 | chr3 | 24018713 | + |
| 5CDS-3UTR | ENST00000397239 | ENST00000492552 | DEK | chr6 | 18236682 | - | NR1D2 | chr3 | 24018713 | + |
| In-frame | ENST00000244776 | ENST00000312521 | DEK | chr6 | 18236682 | - | NR1D2 | chr3 | 24018713 | + |
| In-frame | ENST00000397239 | ENST00000312521 | DEK | chr6 | 18236682 | - | NR1D2 | chr3 | 24018713 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000397239 | DEK | chr6 | 18236682 | - | ENST00000312521 | NR1D2 | chr3 | 24018713 | + | 4891 | 1495 | 448 | 1509 | 353 |
| ENST00000244776 | DEK | chr6 | 18236682 | - | ENST00000312521 | NR1D2 | chr3 | 24018713 | + | 4507 | 1111 | 166 | 1125 | 319 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000397239 | ENST00000312521 | DEK | chr6 | 18236682 | - | NR1D2 | chr3 | 24018713 | + | 0.000168201 | 0.9998318 |
| ENST00000244776 | ENST00000312521 | DEK | chr6 | 18236682 | - | NR1D2 | chr3 | 24018713 | + | 0.000104443 | 0.9998956 |
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Fusion Genomic Features for DEK-NR1D2 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| DEK | chr6 | 18236682 | - | NR1D2 | chr3 | 24018713 | + | 1.22E-06 | 0.9999988 |
| DEK | chr6 | 18236682 | - | NR1D2 | chr3 | 24018713 | + | 1.22E-06 | 0.9999988 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for DEK-NR1D2 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:18236682/chr3:24018713) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DEK | NR1D2 |
| FUNCTION: Involved in chromatin organization. {ECO:0000269|PubMed:17524367}. | FUNCTION: Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARNTL/BMAL1 and CLOCK. Also regulates genes involved in metabolic functions, including lipid metabolism and the inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nuclegotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and also negatively regulates the expression of NR1D1. Regulates lipid and energy homeostasis in the skeletal muscle via repression of genes involved in lipid metabolism and myogenesis including: CD36, FABP3, FABP4, UCP3, SCD1 and MSTN. Regulates hepatic lipid metabolism via the repression of APOC3. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). In addition to its activity as a repressor, can also act as a transcriptional activator. Acts as a transcriptional activator of the sterol regulatory element-binding protein 1 (SREBF1) and the inflammatory mediator interleukin-6 (IL6) in the skeletal muscle (By similarity). Plays a role in the regulation of circadian sleep/wake cycle; essential for maintaining wakefulness during the dark phase or active period (By similarity). Key regulator of skeletal muscle mitochondrial function; negatively regulates the skeletal muscle expression of core clock genes and genes involved in mitochondrial biogenesis, fatty acid beta-oxidation and lipid metabolism (By similarity). May play a role in the circadian control of neutrophilic inflammation in the lung (By similarity). {ECO:0000250|UniProtKB:Q60674, ECO:0000269|PubMed:17892483, ECO:0000269|PubMed:17996965}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DEK | chr6:18236682 | chr3:24018713 | ENST00000244776 | - | 8 | 10 | 228_236 | 315 | 342.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | DEK | chr6:18236682 | chr3:24018713 | ENST00000244776 | - | 8 | 10 | 241_254 | 315 | 342.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | DEK | chr6:18236682 | chr3:24018713 | ENST00000244776 | - | 8 | 10 | 300_310 | 315 | 342.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | DEK | chr6:18236682 | chr3:24018713 | ENST00000244776 | - | 8 | 10 | 30_49 | 315 | 342.0 | Compositional bias | Note=Asp/Glu-rich (highly acidic) |
| Hgene | DEK | chr6:18236682 | chr3:24018713 | ENST00000397239 | - | 9 | 11 | 228_236 | 349 | 376.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | DEK | chr6:18236682 | chr3:24018713 | ENST00000397239 | - | 9 | 11 | 241_254 | 349 | 376.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | DEK | chr6:18236682 | chr3:24018713 | ENST00000397239 | - | 9 | 11 | 300_310 | 349 | 376.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | DEK | chr6:18236682 | chr3:24018713 | ENST00000397239 | - | 9 | 11 | 30_49 | 349 | 376.0 | Compositional bias | Note=Asp/Glu-rich (highly acidic) |
| Hgene | DEK | chr6:18236682 | chr3:24018713 | ENST00000397239 | - | 9 | 11 | 337_351 | 349 | 376.0 | DNA binding | . |
| Hgene | DEK | chr6:18236682 | chr3:24018713 | ENST00000244776 | - | 8 | 10 | 149_183 | 315 | 342.0 | Domain | Note=SAP |
| Hgene | DEK | chr6:18236682 | chr3:24018713 | ENST00000397239 | - | 9 | 11 | 149_183 | 349 | 376.0 | Domain | Note=SAP |
| Hgene | DEK | chr6:18236682 | chr3:24018713 | ENST00000244776 | - | 8 | 10 | 205_221 | 315 | 342.0 | Motif | Nuclear localization signal |
| Hgene | DEK | chr6:18236682 | chr3:24018713 | ENST00000397239 | - | 9 | 11 | 205_221 | 349 | 376.0 | Motif | Nuclear localization signal |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DEK | chr6:18236682 | chr3:24018713 | ENST00000244776 | - | 8 | 10 | 337_351 | 315 | 342.0 | DNA binding | . |
| Hgene | DEK | chr6:18236682 | chr3:24018713 | ENST00000244776 | - | 8 | 10 | 367_371 | 315 | 342.0 | DNA binding | . |
| Hgene | DEK | chr6:18236682 | chr3:24018713 | ENST00000397239 | - | 9 | 11 | 367_371 | 349 | 376.0 | DNA binding | . |
| Tgene | NR1D2 | chr6:18236682 | chr3:24018713 | ENST00000312521 | 6 | 8 | 13_20 | 514 | 580.0 | Compositional bias | Note=Poly-Ser | |
| Tgene | NR1D2 | chr6:18236682 | chr3:24018713 | ENST00000312521 | 6 | 8 | 35_39 | 514 | 580.0 | Compositional bias | Note=Poly-Ser | |
| Tgene | NR1D2 | chr6:18236682 | chr3:24018713 | ENST00000312521 | 6 | 8 | 100_176 | 514 | 580.0 | DNA binding | Nuclear receptor | |
| Tgene | NR1D2 | chr6:18236682 | chr3:24018713 | ENST00000312521 | 6 | 8 | 369_579 | 514 | 580.0 | Domain | NR LBD | |
| Tgene | NR1D2 | chr6:18236682 | chr3:24018713 | ENST00000312521 | 6 | 8 | 1_60 | 514 | 580.0 | Region | Required for phosphorylation by CSNK1E and cytoplasmic localization | |
| Tgene | NR1D2 | chr6:18236682 | chr3:24018713 | ENST00000312521 | 6 | 8 | 1_99 | 514 | 580.0 | Region | Note=Modulating | |
| Tgene | NR1D2 | chr6:18236682 | chr3:24018713 | ENST00000312521 | 6 | 8 | 103_123 | 514 | 580.0 | Zinc finger | NR C4-type | |
| Tgene | NR1D2 | chr6:18236682 | chr3:24018713 | ENST00000312521 | 6 | 8 | 140_164 | 514 | 580.0 | Zinc finger | NR C4-type |
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Fusion Gene Sequence for DEK-NR1D2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >22179_22179_1_DEK-NR1D2_DEK_chr6_18236682_ENST00000244776_NR1D2_chr3_24018713_ENST00000312521_length(transcript)=4507nt_BP=1111nt ATTTTGAAAATCTTGTTGATTCTGGGGAGCCGAGCGCGCGGCGCGAGCGTCACGCCAGACAGCGGCCCGCGCGCCTTCTCCTCGGCGTCG GCCGCCGCCGCCTCCCAGAACCTCCTCGTGCCCTCGCGTGCCAGGCCCGCGGCGGCCGAAATCCGCGGTTCACAGCATGTCCGCCTCGGC CCCTGCTGCGGAGGGGGAGGGAACCCCCACCCAGCCCGCGTCCGAGAAAGAACCCGAAATGCCCGGTCCCAGAGAGGAGAGCGAGGAGGA AGAGGACGAGGACGACGAGGAGGAGGAGGAGGAGGAAAAAGGAAAGGGGCAGAAACTTTGTGAAATTGAGAGGATACATTTTTTTCTAAG TAAGAAGAAAACCGATGAACTTAGAAATCTACACAAACTGCTTTACAACAGGCCAGGCACTGTGTCCTCATTAAAGAAGAATGTGGGTCA GTTCAGTGGCTTTCCATTTGAAAAAGGAAGTGTCCAATATAAAAAGAAGGAAGAAATGTTGAAAAAATTTAGAAATGCCATGTTAAAGAG CATCTGTGAGGTTCTTGATTTGGAGAGATCAGGTGTAAATAGTGAACTAGTGAAGAGGATCTTGAATTTCTTAATGCATCCAAAGCCTTC TGGCAAACCATTGCCGAAATCTAAAAAAACTTGTAGCAAAGGCAGTAAAAAGGAACGGAACAGTTCTGGAATGGCAAGGAAGGCTAAGCG AACCAAATGTCCTGAAATTCTGTCAGATGAATCTAGTAGTGATGAAGATGAAAAGAAAAACAAGGAAGAGTCTTCAGATGATGAAGATAA AGAAAGTGAAGAGGAGCCACCAAAAAAGACAGCCAAAAGAGAAAAACCTAAACAGAAAGCTACTTCTAAAAGTAAAAAATCTGTGAAAAG TGCCAATGTTAAGAAAGCAGATAGCAGCACCACCAAGAAGAATCAAAACAGTTCCAAAAAAGAAAGTGAGTCTGAGGATAGTTCAGATGA TGAACCTTTAATTAAAAAGTTGAAGAAACCCCCTACAGATGAAGAGTTAAAGGAAACAATAAAGAAATTACTGGCCAGTGCTAACTTGGA AGAAGTCACAATGAAACAGATTTGCAAAAAGATCGATCTGGAATAGAAAACGTCAACTCTGTGGAGGCTTTGCAGGAAACTCTCATTCGT GCACTAAGGACCTTAATAATGAAAAACCATCCAAATGAGGCCTCTATTTTTACAAAACTGCTTCTAAAGTTGCCAGATCTTCGATCTTTA AACAACATGCACTCTGAGGAGCTCTTGGCCTTTAAAGTTCACCCTTAAGGCCTTTGTTTATTTAAACATGAACTGATGGTAACTGTACAT TTTGTGCTAAAATGCATATTTATATGTGTATACCATATGTGGAGATAGAAAAGACCTTTAAGACAATAAAAGATTGTAGGCTATCTCTGT AATCATGCAATAGCTGTTCGGATTGAGAACTCTTCAGCCATGATTAGACGTTGACTGCATCTCCCTGATAGACCAATCAGCTGTGTCGCA CTTAAACTGGAGAAGTTACACTGAAGTATAATCACACTGAATGTTAGACTTTTTCATCTGCCAAAACCAAAAACCATTTTGATCTCCCTG TGGTTATCAATATAACGCACAATCACAAGTGTATGAGGACTTAGAAATTAATCCTTTGTGGTAGGAGTTCTGTTGAATGATGGAAATCTT ATTACTACCACAAGACTATTTGATCTGGTAATTGGAGACTTCGGGATTTAGGAGATCTCCATGTCTGTATTTACTCTACCACTGCTAAAG TGTGTGGTCCTGGGTAGTTTACTTGCTTGCGGAAAATGAGAATTGATGGTGTCCCCAATGCCCCACCTCACAGAGTTACTAAAAAATGTC TGTAAAGCATATTTACCTCTTGGGAGATAGGCACTATGTAAATAAGGTAAAATTTCTGTTATTACAATTATTCATAATAATATTCTTTTC TTATTTCTAAGCCTTTCTGGGAAATCATTTCAGTCCACACCAACCATATTATTCAGGGTTCCTGCCATATGTGTGGGGTATCCTACTGAT ACACACGTATTCAAAGTTTATGGGTACAACAAAGACATAGTACATGTACATAATATGTATGTGAATATAGTTAAATATATTTCTTCACAA TATTTTAAACTGTGAAGAACTTTATCATACAGGAAACTTAAAACAAGAGGTGTCAAAAGACCCAAATTAGGTGCATTTTACTTGTTTATG ATGGCATAACCATTGCTTTAAAATGTTTAGACAGTAGAATATTGAATTTATGCTCTATTTTTGTTTATTTAAGCAACACTTAATGTAAAA GTGCAACAGGCAATTGAATCCAAATTTCAACGACAAAAAAAAAAAACATGTATTTTAGAGTTCATCTTTGGCAAAATCTTTGGTTCAGGG TACTAGTTGTTTAAAAGTTGATTCATATTCTTACCTTGTGCTGAGAAAGGTTGCATTGCTGCCCCTTATACACATGCTGCAGCTTGATGT TAAAGAATTTTTATTCTTTCTGAAGAACTAATTAATGTTTAAAGCAACTGTTTAATATGATGGCATGTGTGTGTGTGCGTGCGTGTGTAT GTTCTGAGTCCACTTCTTTTTTCCTAAATAACACTACAGGGATTTTGTCATATTAGATTTAATTTATAATTTGAAAAATCATCTAGTGTG TGACCTACAGGCTTAGAAATGGTATAGTCAAAGACATTTTATCCACATTTCTAATAGTGGACTTGATTAAGTAGATAAGATCAGCATCTG TTTATGGTAGTAGGAGAAATAGCCAAAGTTGAGGATTTTATGTATGTTTTCCTGTTTACCTGGAAAATAGCAATTAATTGGATTTTTTGG TAAAGATTGCCTTCTGTATAATGTTTGGATTATATAAAATTGCAAAAATGATAACAGCCCGCTTTACTGTACTAAGCCTGTTACTTTCAT GACGTGTGAGCAGAATGCCTTATTTTGTAATCTTGTTTAACTTGTTGCTACTGGGACTTGATTTACTGTGGCACTAGTTAAGTAAGTTAA AAAAAAGTTAAACCCTCTCATTATTAAAGAGGAAAGGCGATGGTGATGTCTGTAGTACAATATAAACCATAATTGTGATTTACCTTAAGT AGGTATAACTCTTATGGGATATACAGTATAGTTTTTGTGAATCTTTACATGATAGCATTATCTTTTTATAATTTTTTTTCCTAAGATAAA CAAATGCATAGTTTTCTTCTATGGGTGATAGAAACAGCTTTTTGAAGTAATGAAAACCTCAAAAGATCATGTTGATTCTTAATTTTTGCC TTTTGCATAAGCCTCTTTATAACATGTATCTTTAAAACAATTAAGTCTTTAGGAATGTGTAACCAGAACTATGTTAGTATTGCTTATAAA ACTTTAGTTAGGTTCAATATATACATATATACATCTCTATATAGGTATATAGATTTGCATTTTGTCTTGTAAAATTTTATTTGAATAAAT TCTTCCTGTAGGTAATGGGAAACAAAATTAATAGTTCATATGTCACTCATAGCATTTCTATATTTGAAAGTAGCCCAATATAAAACTTTT GATTCTAAAATTAAACCAGCAGCCTATTACAAGCACATTCTTTGATTGAGTCATTGGTTATAAACTTACTAAATGCAGAGAAAGCAGCCA ATTTAGGAAACTTCTGAGTTGGTGGGACACTGTTGATTAATAATGTACTGTATGAATTAAGTGATGCTTTAACTTTGATTTTACATTTTA AAGTTAAAATGTGGGCATTATGTCAGCAAACTTAAGGGCATTATGTCAGCAAGCTAAAACATTTTTTTTCCTGTGCTTTTAATGTATCTC TTTACATGATCTGAGAGAGGATTCAAGTTGATAGAAATAGCTGAGGGGAAAAGGGGGAACATCTTGGGATGAAGCTTGTCCTTATGGTGA TGGTTTAATTACAGATTAAAAAATTAGAAGGAAATTTCAGTGGATTAAGTGTATAGCTTTCATATCTACATTTCAAGAAATTACCATTGT AACTTGATAAGAGATGATTTATTTTATGTAAACATCTTTGCAAAGCAAGGTGTAGCAGCTCAGCTAGATTTATTACTGTGCACGAAAGTA AATACCTATCTCAATTATTCTTTTTCTTTTCCAATATAAAGTTTGCTGAATGTACAAGAAGAGTTTATCACTTAGGATATAGAATTTTTT TAGGGGTTGGGGGAGGGGATCTGTTAGGAAACTGTTACCTATAAACAAAGATTGACTGGATTCGATCCAAAAGATAAAACTTGAAGCTAT TCTGGAACTAACATGGAAAAATGAAATGGCTATTGTTTAAAAAAATGATAGAAATACATTGTTGATGGGATATGAGTTAAGTTTATTTTC TACAAACTGTAATTGATGAGGACATGGATAATATCTTCATGTTTCTGAGAAGTAATCTGTATGTGGGGGGAGGGGATAATAAATATTTCT AACCAAC >22179_22179_1_DEK-NR1D2_DEK_chr6_18236682_ENST00000244776_NR1D2_chr3_24018713_ENST00000312521_length(amino acids)=319AA_BP= MSASAPAAEGEGTPTQPASEKEPEMPGPREESEEEEDEDDEEEEEEEKGKGQKLCEIERIHFFLSKKKTDELRNLHKLLYNRPGTVSSLK KNVGQFSGFPFEKGSVQYKKKEEMLKKFRNAMLKSICEVLDLERSGVNSELVKRILNFLMHPKPSGKPLPKSKKTCSKGSKKERNSSGMA RKAKRTKCPEILSDESSSDEDEKKNKEESSDDEDKESEEEPPKKTAKREKPKQKATSKSKKSVKSANVKKADSSTTKKNQNSSKKESESE DSSDDEPLIKKLKKPPTDEELKETIKKLLASANLEEVTMKQICKKIDLE -------------------------------------------------------------- >22179_22179_2_DEK-NR1D2_DEK_chr6_18236682_ENST00000397239_NR1D2_chr3_24018713_ENST00000312521_length(transcript)=4891nt_BP=1495nt TCCGCGCTGCCAGGCCGCCTCGCCTCCCGCTCCCGCCCGCCCCGCGGGACACAGCCCGCCCGCACTCCGGGGCCCGAGCGCCGACCACAC TCCAGGCGCAGCCGGGGAGAGCCCCGCGCGCGCATCCCTCCGCCCGCGGCCGAGGCGACCCCTCGCGGTCCCGCCCGCCCGAGCTTCCCG CGGAGGCACCCGGCCGCCCCGCCTCCCCCGCCCCGCGCCCGCCAACTCCCAGCTCGCGGCCCTGATTGGTCGCCGCATTCCCGCTCTCCT TCCCGAACCGCCATTTTGAAAATCTTGTTGATTCTGGGGAGCCGAGCGCGCGGCGCGAGCGTCACGCCAGACAGCGGCCCGCGCGCCTTC TCCTCGGCGTCGGCCGCCGCCGCCTCCCAGAACCTCCTCGTGCCCTCGCGTGCCAGGCCCGCGGCGGCCGAAATCCGCGGTTCACAGCAT GTCCGCCTCGGCCCCTGCTGCGGAGGGGGAGGGAACCCCCACCCAGCCCGCGTCCGAGAAAGAACCCGAAATGCCCGGTCCCAGAGAGGA GAGCGAGGAGGAAGAGGACGAGGACGACGAGGAGGAGGAGGAGGAGGAAAAAGAAAAGAGTCTCATCGTGGAAGGCAAGAGGGAAAAGAA AAAAGTAGAGAGGTTGACAATGCAAGTCTCTTCCTTACAGAGAGAGCCATTTACAATTGCACAAGGAAAGGGGCAGAAACTTTGTGAAAT TGAGAGGATACATTTTTTTCTAAGTAAGAAGAAAACCGATGAACTTAGAAATCTACACAAACTGCTTTACAACAGGCCAGGCACTGTGTC CTCATTAAAGAAGAATGTGGGTCAGTTCAGTGGCTTTCCATTTGAAAAAGGAAGTGTCCAATATAAAAAGAAGGAAGAAATGTTGAAAAA ATTTAGAAATGCCATGTTAAAGAGCATCTGTGAGGTTCTTGATTTGGAGAGATCAGGTGTAAATAGTGAACTAGTGAAGAGGATCTTGAA TTTCTTAATGCATCCAAAGCCTTCTGGCAAACCATTGCCGAAATCTAAAAAAACTTGTAGCAAAGGCAGTAAAAAGGAACGGAACAGTTC TGGAATGGCAAGGAAGGCTAAGCGAACCAAATGTCCTGAAATTCTGTCAGATGAATCTAGTAGTGATGAAGATGAAAAGAAAAACAAGGA AGAGTCTTCAGATGATGAAGATAAAGAAAGTGAAGAGGAGCCACCAAAAAAGACAGCCAAAAGAGAAAAACCTAAACAGAAAGCTACTTC TAAAAGTAAAAAATCTGTGAAAAGTGCCAATGTTAAGAAAGCAGATAGCAGCACCACCAAGAAGAATCAAAACAGTTCCAAAAAAGAAAG TGAGTCTGAGGATAGTTCAGATGATGAACCTTTAATTAAAAAGTTGAAGAAACCCCCTACAGATGAAGAGTTAAAGGAAACAATAAAGAA ATTACTGGCCAGTGCTAACTTGGAAGAAGTCACAATGAAACAGATTTGCAAAAAGATCGATCTGGAATAGAAAACGTCAACTCTGTGGAG GCTTTGCAGGAAACTCTCATTCGTGCACTAAGGACCTTAATAATGAAAAACCATCCAAATGAGGCCTCTATTTTTACAAAACTGCTTCTA AAGTTGCCAGATCTTCGATCTTTAAACAACATGCACTCTGAGGAGCTCTTGGCCTTTAAAGTTCACCCTTAAGGCCTTTGTTTATTTAAA CATGAACTGATGGTAACTGTACATTTTGTGCTAAAATGCATATTTATATGTGTATACCATATGTGGAGATAGAAAAGACCTTTAAGACAA TAAAAGATTGTAGGCTATCTCTGTAATCATGCAATAGCTGTTCGGATTGAGAACTCTTCAGCCATGATTAGACGTTGACTGCATCTCCCT GATAGACCAATCAGCTGTGTCGCACTTAAACTGGAGAAGTTACACTGAAGTATAATCACACTGAATGTTAGACTTTTTCATCTGCCAAAA CCAAAAACCATTTTGATCTCCCTGTGGTTATCAATATAACGCACAATCACAAGTGTATGAGGACTTAGAAATTAATCCTTTGTGGTAGGA GTTCTGTTGAATGATGGAAATCTTATTACTACCACAAGACTATTTGATCTGGTAATTGGAGACTTCGGGATTTAGGAGATCTCCATGTCT GTATTTACTCTACCACTGCTAAAGTGTGTGGTCCTGGGTAGTTTACTTGCTTGCGGAAAATGAGAATTGATGGTGTCCCCAATGCCCCAC CTCACAGAGTTACTAAAAAATGTCTGTAAAGCATATTTACCTCTTGGGAGATAGGCACTATGTAAATAAGGTAAAATTTCTGTTATTACA ATTATTCATAATAATATTCTTTTCTTATTTCTAAGCCTTTCTGGGAAATCATTTCAGTCCACACCAACCATATTATTCAGGGTTCCTGCC ATATGTGTGGGGTATCCTACTGATACACACGTATTCAAAGTTTATGGGTACAACAAAGACATAGTACATGTACATAATATGTATGTGAAT ATAGTTAAATATATTTCTTCACAATATTTTAAACTGTGAAGAACTTTATCATACAGGAAACTTAAAACAAGAGGTGTCAAAAGACCCAAA TTAGGTGCATTTTACTTGTTTATGATGGCATAACCATTGCTTTAAAATGTTTAGACAGTAGAATATTGAATTTATGCTCTATTTTTGTTT ATTTAAGCAACACTTAATGTAAAAGTGCAACAGGCAATTGAATCCAAATTTCAACGACAAAAAAAAAAAACATGTATTTTAGAGTTCATC TTTGGCAAAATCTTTGGTTCAGGGTACTAGTTGTTTAAAAGTTGATTCATATTCTTACCTTGTGCTGAGAAAGGTTGCATTGCTGCCCCT TATACACATGCTGCAGCTTGATGTTAAAGAATTTTTATTCTTTCTGAAGAACTAATTAATGTTTAAAGCAACTGTTTAATATGATGGCAT GTGTGTGTGTGCGTGCGTGTGTATGTTCTGAGTCCACTTCTTTTTTCCTAAATAACACTACAGGGATTTTGTCATATTAGATTTAATTTA TAATTTGAAAAATCATCTAGTGTGTGACCTACAGGCTTAGAAATGGTATAGTCAAAGACATTTTATCCACATTTCTAATAGTGGACTTGA TTAAGTAGATAAGATCAGCATCTGTTTATGGTAGTAGGAGAAATAGCCAAAGTTGAGGATTTTATGTATGTTTTCCTGTTTACCTGGAAA ATAGCAATTAATTGGATTTTTTGGTAAAGATTGCCTTCTGTATAATGTTTGGATTATATAAAATTGCAAAAATGATAACAGCCCGCTTTA CTGTACTAAGCCTGTTACTTTCATGACGTGTGAGCAGAATGCCTTATTTTGTAATCTTGTTTAACTTGTTGCTACTGGGACTTGATTTAC TGTGGCACTAGTTAAGTAAGTTAAAAAAAAGTTAAACCCTCTCATTATTAAAGAGGAAAGGCGATGGTGATGTCTGTAGTACAATATAAA CCATAATTGTGATTTACCTTAAGTAGGTATAACTCTTATGGGATATACAGTATAGTTTTTGTGAATCTTTACATGATAGCATTATCTTTT TATAATTTTTTTTCCTAAGATAAACAAATGCATAGTTTTCTTCTATGGGTGATAGAAACAGCTTTTTGAAGTAATGAAAACCTCAAAAGA TCATGTTGATTCTTAATTTTTGCCTTTTGCATAAGCCTCTTTATAACATGTATCTTTAAAACAATTAAGTCTTTAGGAATGTGTAACCAG AACTATGTTAGTATTGCTTATAAAACTTTAGTTAGGTTCAATATATACATATATACATCTCTATATAGGTATATAGATTTGCATTTTGTC TTGTAAAATTTTATTTGAATAAATTCTTCCTGTAGGTAATGGGAAACAAAATTAATAGTTCATATGTCACTCATAGCATTTCTATATTTG AAAGTAGCCCAATATAAAACTTTTGATTCTAAAATTAAACCAGCAGCCTATTACAAGCACATTCTTTGATTGAGTCATTGGTTATAAACT TACTAAATGCAGAGAAAGCAGCCAATTTAGGAAACTTCTGAGTTGGTGGGACACTGTTGATTAATAATGTACTGTATGAATTAAGTGATG CTTTAACTTTGATTTTACATTTTAAAGTTAAAATGTGGGCATTATGTCAGCAAACTTAAGGGCATTATGTCAGCAAGCTAAAACATTTTT TTTCCTGTGCTTTTAATGTATCTCTTTACATGATCTGAGAGAGGATTCAAGTTGATAGAAATAGCTGAGGGGAAAAGGGGGAACATCTTG GGATGAAGCTTGTCCTTATGGTGATGGTTTAATTACAGATTAAAAAATTAGAAGGAAATTTCAGTGGATTAAGTGTATAGCTTTCATATC TACATTTCAAGAAATTACCATTGTAACTTGATAAGAGATGATTTATTTTATGTAAACATCTTTGCAAAGCAAGGTGTAGCAGCTCAGCTA GATTTATTACTGTGCACGAAAGTAAATACCTATCTCAATTATTCTTTTTCTTTTCCAATATAAAGTTTGCTGAATGTACAAGAAGAGTTT ATCACTTAGGATATAGAATTTTTTTAGGGGTTGGGGGAGGGGATCTGTTAGGAAACTGTTACCTATAAACAAAGATTGACTGGATTCGAT CCAAAAGATAAAACTTGAAGCTATTCTGGAACTAACATGGAAAAATGAAATGGCTATTGTTTAAAAAAATGATAGAAATACATTGTTGAT GGGATATGAGTTAAGTTTATTTTCTACAAACTGTAATTGATGAGGACATGGATAATATCTTCATGTTTCTGAGAAGTAATCTGTATGTGG GGGGAGGGGATAATAAATATTTCTAACCAAC >22179_22179_2_DEK-NR1D2_DEK_chr6_18236682_ENST00000397239_NR1D2_chr3_24018713_ENST00000312521_length(amino acids)=353AA_BP= MSASAPAAEGEGTPTQPASEKEPEMPGPREESEEEEDEDDEEEEEEEKEKSLIVEGKREKKKVERLTMQVSSLQREPFTIAQGKGQKLCE IERIHFFLSKKKTDELRNLHKLLYNRPGTVSSLKKNVGQFSGFPFEKGSVQYKKKEEMLKKFRNAMLKSICEVLDLERSGVNSELVKRIL NFLMHPKPSGKPLPKSKKTCSKGSKKERNSSGMARKAKRTKCPEILSDESSSDEDEKKNKEESSDDEDKESEEEPPKKTAKREKPKQKAT SKSKKSVKSANVKKADSSTTKKNQNSSKKESESEDSSDDEPLIKKLKKPPTDEELKETIKKLLASANLEEVTMKQICKKIDLE -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for DEK-NR1D2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | NR1D2 | chr6:18236682 | chr3:24018713 | ENST00000312521 | 6 | 8 | 397_579 | 514.3333333333334 | 580.0 | ZNHIT1 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for DEK-NR1D2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for DEK-NR1D2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | DEK | C0027626 | Neoplasm Invasiveness | 2 | CTD_human |
| Hgene | DEK | C0006142 | Malignant neoplasm of breast | 1 | CTD_human |
| Hgene | DEK | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Hgene | DEK | C0678222 | Breast Carcinoma | 1 | CTD_human |
| Hgene | DEK | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human |
| Hgene | DEK | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Hgene | DEK | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |
| Tgene | C0014175 | Endometriosis | 1 | CTD_human | |
| Tgene | C0269102 | Endometrioma | 1 | CTD_human |
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