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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACSS3-KRT77 (FusionGDB2 ID:HG79611TG374454)

Fusion Gene Summary for ACSS3-KRT77

check button Fusion gene summary
Fusion gene informationFusion gene name: ACSS3-KRT77
Fusion gene ID: hg79611tg374454
HgeneTgene
Gene symbol

ACSS3

KRT77

Gene ID

79611

374454

Gene nameacyl-CoA synthetase short chain family member 3keratin 77
Synonyms-K1B|KRT1B
Cytomap('ACSS3')('KRT77')

12q21.31

12q13.13

Type of geneprotein-codingprotein-coding
Descriptionacyl-CoA synthetase short-chain family member 3, mitochondrialAMP-binding enzyme, 33217acetate--CoA ligase 3propionate--CoA ligasekeratin, type II cytoskeletal 1bCK-1BK77cytokeratin-1Bkeratin 1Bkeratin 77, type IItype-II keratin Kb39
Modification date2020031320200313
UniProtAcc

Q9H6R3

.
Ensembl transtripts involved in fusion geneENST00000261206, ENST00000548058, 
ENST00000548324, 
Fusion gene scores* DoF score9 X 7 X 2=1262 X 2 X 2=8
# samples 82
** MAII scorelog2(8/126*10)=-0.655351828612554
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: ACSS3 [Title/Abstract] AND KRT77 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACSS3(81503483)-KRT77(53091680), # samples:1
Anticipated loss of major functional domain due to fusion event.ACSS3-KRT77 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACSS3-KRT77 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACSS3-KRT77 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ACSS3-KRT77 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ACSS3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across KRT77 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A23YACSS3chr12

81503483

+KRT77chr12

53091680

-


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Fusion Gene ORF analysis for ACSS3-KRT77

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000261206ENST00000537195ACSS3chr12

81503483

+KRT77chr12

53091680

-
5CDS-5UTRENST00000548058ENST00000537195ACSS3chr12

81503483

+KRT77chr12

53091680

-
In-frameENST00000261206ENST00000341809ACSS3chr12

81503483

+KRT77chr12

53091680

-
In-frameENST00000548058ENST00000341809ACSS3chr12

81503483

+KRT77chr12

53091680

-
intron-3CDSENST00000548324ENST00000341809ACSS3chr12

81503483

+KRT77chr12

53091680

-
intron-5UTRENST00000548324ENST00000537195ACSS3chr12

81503483

+KRT77chr12

53091680

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000548058ACSS3chr1281503483+ENST00000341809KRT77chr1253091680-409913667392559606
ENST00000261206ACSS3chr1281503483+ENST00000341809KRT77chr1253091680-3250517641710548

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000548058ENST00000341809ACSS3chr1281503483+KRT77chr1253091680-0.0119598870.98804015
ENST00000261206ENST00000341809ACSS3chr1281503483+KRT77chr1253091680-0.0144965020.98550355

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Fusion Genomic Features for ACSS3-KRT77


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ACSS3-KRT77


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:81503483/chr12:53091680)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACSS3

Q9H6R3

.
FUNCTION: Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:28003429). Propionate is the preferred substrate (PubMed:28003429). Can utilize acetate and butyrate with a much lower affinity (By similarity). {ECO:0000250|UniProtKB:A0A0G2K047, ECO:0000269|PubMed:28003429}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKRT77chr12:81503483chr12:53091680ENST0000034180909201_219181579.0RegionNote=Linker 1
TgeneKRT77chr12:81503483chr12:53091680ENST0000034180909220_311181579.0RegionNote=Coil 1B
TgeneKRT77chr12:81503483chr12:53091680ENST0000034180909312_335181579.0RegionNote=Linker 12
TgeneKRT77chr12:81503483chr12:53091680ENST0000034180909336_474181579.0RegionNote=Coil 2
TgeneKRT77chr12:81503483chr12:53091680ENST0000034180909475_578181579.0RegionNote=Tail

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACSS3chr12:81503483chr12:53091680ENST00000548058+216425_427152687.0Nucleotide bindingATP
HgeneACSS3chr12:81503483chr12:53091680ENST00000548058+216446_451152687.0Nucleotide bindingATP
HgeneACSS3chr12:81503483chr12:53091680ENST00000548324+111425_4270369.0Nucleotide bindingATP
HgeneACSS3chr12:81503483chr12:53091680ENST00000548324+111446_4510369.0Nucleotide bindingATP
HgeneACSS3chr12:81503483chr12:53091680ENST00000548058+216227_230152687.0RegionCoenzyme A binding
HgeneACSS3chr12:81503483chr12:53091680ENST00000548324+111227_2300369.0RegionCoenzyme A binding
TgeneKRT77chr12:81503483chr12:53091680ENST0000034180909164_477181579.0DomainIF rod
TgeneKRT77chr12:81503483chr12:53091680ENST0000034180909164_200181579.0RegionNote=Coil 1A
TgeneKRT77chr12:81503483chr12:53091680ENST00000341809091_163181579.0RegionNote=Head


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Fusion Gene Sequence for ACSS3-KRT77


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>1550_1550_1_ACSS3-KRT77_ACSS3_chr12_81503483_ENST00000261206_KRT77_chr12_53091680_ENST00000341809_length(transcript)=3250nt_BP=517nt
GGCCCCAGGAAGTTGCAAGAGTACCATTTGTCGCACACTCGGGGACCGCGGGTGGCCGGAGGAGATGAAACCGTCTTGGCTGCAGTGTCG
TAAAGTCACCAGCGCCGGGGGGCTCGGAGGGCCCTTGCCTGGGTCCTCTCCGGCCCGGGGAGCCGGTGCGGCCCTCAGGGCTTTAGTGGT
CCCGGGCCCGCGGGGCGGTCTCGGGGGCCGGGGATGCAGGGCACTGTCCTCCGGCAGTGGCAGCGAGTACAAGACCCACTTCGCAGCCTC
GGTGACCGACCCCGAGAGGTTCTGGGGCAAAGCTGCCGAGCAGATCAGCTGGTACAAGCCCTGGACCAAAACGCTGGAGAACAAACACTC
GCCCTCTACCAGGTTTGTGGAAGGAATGCTTAACATTTGTTACAATGCCGTTGATCGTCATATTGAAAATGGTAAAGGGGATAAGATTGC
TATCATCTATGACAGTCCTGTTACAAACACTAAAGCAACCTTTACCTATAAAGAAGTTCTGGAGCAGGTGCGATTCCTGGAGCAGCAGAA
CCAGGTGCTACAAACAAAATGGGAGTTGCTGCAGCAGGTGAACACCTCAACTGGAACCAACAACCTGGAGCCCCTCTTGGAGAACTACAT
CGGTGACCTGCGGAGGCAGGTGGATTTGCTCAGTGCGGAGCAGATGCGCCAGAACGCGGAGGTCAGGAGCATGCAGGATGTCGTGGAGGA
CTACAAGAGCAAGTATGAGGATGAAATCAACAAGAGGACTGGCAGCGAGAATGACTTTGTCGTCCTGAAGAAGGATGTGGATGCTGCTTA
TGTGAGCAAAGTGGACCTGGAGTCCAGGGTGGACACTCTGACTGGGGAGGTCAATTTCTTGAAATATTTATTTTTGACGGAGCTGTCTCA
GGTGCAGACTCACATCAGCGACACCAACGTCATCCTGTCCATGGACAATAACCGTTCCCTGGACCTGGACAGCATCATCGATGCAGTGCG
GACCCAGTATGAACTGATTGCACAGAGGAGCAAGGACGAGGCCGAAGCCCTGTACCAGACCAAGTACCAGGAGCTCCAGATCACGGCAGG
GAGACATGGAGACGACCTGAAGAACAGCAAGATGGAGATTGCAGAGCTCAACCGCACCGTCCAGAGGCTGCAGGCAGAGATCAGCAACGT
GAAGAAGCAGATTGAACAGATGCAGTCACTCATTTCGGATGCTGAGGAGAGAGGCGAGCAGGCCCTCCAGGATGCGTGGCAGAAGCTGCA
GGACCTGGAGGAGGCCCTGCAGCAGTCCAAGGAGGAGCTGGCCCGGCTGCTGCGTGACTACCAGGCCATGCTGGGGGTCAAGCTGTCCCT
GGATGTGGAGATCGCCACCTACCGCCAGCTGCTGGAGGGCGAGGAGAGCAGGATGTCAGGAGAGCTGCAGAGCCATGTGAGCATCTCCGT
GCAGAACAGCCAGGTGAGCGTCAACGGCGGCGCGGGAGGCGGCGGCAGCTACGGCTCAGGAGGCTACGGCGGCGGCAGCGGTGGGGGCTA
TGGCGGCGGAAGAAGCTACCGCGGAGGCGGGGCACGAGGCAGGAGTGGAGGCGGTTATGGCAGCGGCTGCGGCGGCGGTGGCGGGAGCTA
CGGAGGGAGCGGCAGAAGCGGCCGCGGATCCTCGCGCGTGCAGATCATCCAGACCTCCACCAACACCTCCCACAGGCGGATCTTGGAGTA
GAGGCCTCGTTTCTGCCACACATCACGCCTGCCCCTCACCGCCCTCTCCTCAAACTCCTCCCCTCCACGCCCTTCCTGATCCCCTCTCAT
TCACTTTTCTTAATGGGTCTCAGCAATTTTGCCAATAAATTCGACTCTAATGGGGGAAGCAGGGTGGATAAGTCCAAACAGCAGATCTCT
CTTTGGAGGGCACTGGCTTGCAGTCAGATTCACAGCTAGGCACATTCTCACTCAGACCCCGCTCTGCTGGCCCTGCTGCTGTTCCTGCTC
CCACCTTTTTGGAAGATCGGTAGCCCAGGGTGAGCACAAACATTCCAGTTAGAGGCAGAGGCTGCGTGAGTTGGCAAGGTAGGGAGAAGT
CATTGTTATCATTCCTCTGCCTCCAAGTAGAATGCCCTTATGCCCCAGTTCAAGCCACTGCAGCTAAGTATTAATCCCCAGTGCTAAAAG
ATACCAGGCATCTAGTTTAGCAATGGAGGGAAACAGAAACAGCCTGTAGAGAGCATCGACAAGGCGCATAATGGAGAGTTGGTATCTCAA
CCCCAAGCTCCCTTTGCTGTACCTGGGCTGCTCTGTGAACAAGAATCCACGCCCCCCTGCCCTGCTGGGGACCACATAATGATCCCTTTG
GGGGAAGTTGCTGATTGCAGGGCAAGCTAGCTTGGTAAGGAAAACCTCTGCACCAGCGGCCTATTCCTGCCTCTTGGTCCATAGCCTCAT
ACACTCATGTTGATGGATAGTATAGATTTGCTGCCCACACCAGATATCTGTAAGGCATCACTGTCCTGATTCTGAACCTCTGTTTCAGGA
AGCATTCTCCCCTGTGTAAACAACTCAAGGTGGAAGTATTTCAGAGGGCATAGGGTCATGAATCCTTACCCAAAGGAAGCCTGTTTTAGC
AGTGGATGCAGGAGTTGATGAACAGACAAGCAAGTTCTGCTTCTGTCCTGTTTCCTCCTGACAGCTCCATTCTTTTGAAGCCTGACCCTT
CCTAAGCTCTGCATCATAACCACTCTGAGAATTGCCCCATTGGGTGGGCATGTGAAGCCCAGCTCTGTTCCATCCAGGTGCCTCGGGCCT
GAGGAGTCTGAGGATCTGACTTGGGTCTTGGAAGGGTTCCAACCCCAAGTCAGTCAGGAAGCTGCCCATTTTTTTGCAAGGCATTTTAAT
GCCCTTTCCCAGACCTCTCTAGTCCCTCCTGCCTTCTGTTCTCTGTAGCTGTGAGCCCTTTGTGAGAATATGACTCTTAATTTTGAATCT
TATGTAAGAGGCTTGAGATGTGCTGGAGAGGGCAGGAAGAGGAAAGTATCAGGCCTTGAGAGAGGGAATGTAGCTTTGCTTCTATGATCT
GGAGTCACCTTCACTTGCTAGCTGAGTCCTAACACAACTTCCAAGTCCATGATTCTCTTGGGGCATTGGATGGGCTCAGTGTGGGTCTCT
TAGGCTGTTCTTGTGACTTCATCATTTCCTGGTTCAAAGTTGTACTGTCAAGGGGCAGCATTTCTGGTATTTCTATAATAAATTTTTCTG

>1550_1550_1_ACSS3-KRT77_ACSS3_chr12_81503483_ENST00000261206_KRT77_chr12_53091680_ENST00000341809_length(amino acids)=548AA_BP=150
MKPSWLQCRKVTSAGGLGGPLPGSSPARGAGAALRALVVPGPRGGLGGRGCRALSSGSGSEYKTHFAASVTDPERFWGKAAEQISWYKPW
TKTLENKHSPSTRFVEGMLNICYNAVDRHIENGKGDKIAIIYDSPVTNTKATFTYKEVLEQVRFLEQQNQVLQTKWELLQQVNTSTGTNN
LEPLLENYIGDLRRQVDLLSAEQMRQNAEVRSMQDVVEDYKSKYEDEINKRTGSENDFVVLKKDVDAAYVSKVDLESRVDTLTGEVNFLK
YLFLTELSQVQTHISDTNVILSMDNNRSLDLDSIIDAVRTQYELIAQRSKDEAEALYQTKYQELQITAGRHGDDLKNSKMEIAELNRTVQ
RLQAEISNVKKQIEQMQSLISDAEERGEQALQDAWQKLQDLEEALQQSKEELARLLRDYQAMLGVKLSLDVEIATYRQLLEGEESRMSGE
LQSHVSISVQNSQVSVNGGAGGGGSYGSGGYGGGSGGGYGGGRSYRGGGARGRSGGGYGSGCGGGGGSYGGSGRSGRGSSRVQIIQTSTN

--------------------------------------------------------------
>1550_1550_2_ACSS3-KRT77_ACSS3_chr12_81503483_ENST00000548058_KRT77_chr12_53091680_ENST00000341809_length(transcript)=4099nt_BP=1366nt
CTTTCTTTTTACATTTTCCCAGTTTCCTCTTTTGATTCATCTTTACTTACTTCCTATTTTTGTTTTTTGTTTATTTGTTTGTTTTGTTTT
CTCATTAGAAAAGCCACAGAAACTCCAAGCAGGCAAATTAGAAGGGAGGCAATGCAACAAGTCCTATCTGTTCTCTGTCTAGATCACATG
CGGAGTCTGGTCAGCAGGTGAATCCGCATCCCAGTGGGGTCACCTTCCCTGTGACCTGTCAATCACCCCAAGAAGCACTTCCCAATTTGT
CTGGCACAACCTCCTTCCACTCCTCCTACCCTCTCAGTGGTCAGGAAATCCCGGAGCAGTCCTTGCCCTGGAGCTGCTTGTGTTTTTAGT
AACCAGGGACTGAGCTGATTTTGAAAAATCAATCAATCAATAAATAACAATCAAAGAGCCTTGCCTCAACGCACCGAGTTGCTGGTTTCC
TGCAGGTCAGAGGCGATGCCACCTCCACCAACGACCTTCCAAAGATTAAACCAGCCGTGTACAAACTGCTGGATTGAAAATTGAGAGATG
GGCCGTTGGCCTCCTCCTAGGAGTACTTGTGTGTTGAAATCGGAAGGACGTTCTGGAGTTTGAGCGCGATTTTTCCCGGAAGGCTGCGGG
GTTGGAAGTGCATGTTGGGGTTTGGATCTCGTGCAGCAGCGCAACTAACCTGCTGCAACGGCGCTGTGACACCCCTGTCCCGGGGCCCCC
ACTTTAGCCTGTTGCTTCTCTGGTCGCTCCAGGTCGGTTTTTCCCGGCGACTCTAGTGTGGCTTCCAAACTTCTGGGCTCTGGGCTCACT
TCGGAATTTGCCCCCGCCCCCTACTCCCTTCCCTCAGGCCCCAGGAAGTTGCAAGAGTACCATTTGTCGCACACTCGGGGACCGCGGGTG
GCCGGAGGAGATGAAACCGTCTTGGCTGCAGTGTCGTAAAGTCACCAGCGCCGGGGGGCTCGGAGGGCCCTTGCCTGGGTCCTCTCCGGC
CCGGGGAGCCGGTGCGGCCCTCAGGGCTTTAGTGGTCCCGGGCCCGCGGGGCGGTCTCGGGGGCCGGGGATGCAGGGCACTGTCCTCCGG
CAGTGGCAGCGAGTACAAGACCCACTTCGCAGCCTCGGTGACCGACCCCGAGAGGTTCTGGGGCAAAGCTGCCGAGCAGATCAGCTGGTA
CAAGCCCTGGACCAAAACGCTGGAGAACAAACACTCGCCCTCTACCAGGTGGTTTGTGGAAGGAATGCTTAACATTTGTTACAATGCCGT
TGATCGTCATATTGAAAATGGTAAAGGGGATAAGATTGCTATCATCTATGACAGTCCTGTTACAAACACTAAAGCAACCTTTACCTATAA
AGAAGTTCTGGAGCAGGTGCGATTCCTGGAGCAGCAGAACCAGGTGCTACAAACAAAATGGGAGTTGCTGCAGCAGGTGAACACCTCAAC
TGGAACCAACAACCTGGAGCCCCTCTTGGAGAACTACATCGGTGACCTGCGGAGGCAGGTGGATTTGCTCAGTGCGGAGCAGATGCGCCA
GAACGCGGAGGTCAGGAGCATGCAGGATGTCGTGGAGGACTACAAGAGCAAGTATGAGGATGAAATCAACAAGAGGACTGGCAGCGAGAA
TGACTTTGTCGTCCTGAAGAAGGATGTGGATGCTGCTTATGTGAGCAAAGTGGACCTGGAGTCCAGGGTGGACACTCTGACTGGGGAGGT
CAATTTCTTGAAATATTTATTTTTGACGGAGCTGTCTCAGGTGCAGACTCACATCAGCGACACCAACGTCATCCTGTCCATGGACAATAA
CCGTTCCCTGGACCTGGACAGCATCATCGATGCAGTGCGGACCCAGTATGAACTGATTGCACAGAGGAGCAAGGACGAGGCCGAAGCCCT
GTACCAGACCAAGTACCAGGAGCTCCAGATCACGGCAGGGAGACATGGAGACGACCTGAAGAACAGCAAGATGGAGATTGCAGAGCTCAA
CCGCACCGTCCAGAGGCTGCAGGCAGAGATCAGCAACGTGAAGAAGCAGATTGAACAGATGCAGTCACTCATTTCGGATGCTGAGGAGAG
AGGCGAGCAGGCCCTCCAGGATGCGTGGCAGAAGCTGCAGGACCTGGAGGAGGCCCTGCAGCAGTCCAAGGAGGAGCTGGCCCGGCTGCT
GCGTGACTACCAGGCCATGCTGGGGGTCAAGCTGTCCCTGGATGTGGAGATCGCCACCTACCGCCAGCTGCTGGAGGGCGAGGAGAGCAG
GATGTCAGGAGAGCTGCAGAGCCATGTGAGCATCTCCGTGCAGAACAGCCAGGTGAGCGTCAACGGCGGCGCGGGAGGCGGCGGCAGCTA
CGGCTCAGGAGGCTACGGCGGCGGCAGCGGTGGGGGCTATGGCGGCGGAAGAAGCTACCGCGGAGGCGGGGCACGAGGCAGGAGTGGAGG
CGGTTATGGCAGCGGCTGCGGCGGCGGTGGCGGGAGCTACGGAGGGAGCGGCAGAAGCGGCCGCGGATCCTCGCGCGTGCAGATCATCCA
GACCTCCACCAACACCTCCCACAGGCGGATCTTGGAGTAGAGGCCTCGTTTCTGCCACACATCACGCCTGCCCCTCACCGCCCTCTCCTC
AAACTCCTCCCCTCCACGCCCTTCCTGATCCCCTCTCATTCACTTTTCTTAATGGGTCTCAGCAATTTTGCCAATAAATTCGACTCTAAT
GGGGGAAGCAGGGTGGATAAGTCCAAACAGCAGATCTCTCTTTGGAGGGCACTGGCTTGCAGTCAGATTCACAGCTAGGCACATTCTCAC
TCAGACCCCGCTCTGCTGGCCCTGCTGCTGTTCCTGCTCCCACCTTTTTGGAAGATCGGTAGCCCAGGGTGAGCACAAACATTCCAGTTA
GAGGCAGAGGCTGCGTGAGTTGGCAAGGTAGGGAGAAGTCATTGTTATCATTCCTCTGCCTCCAAGTAGAATGCCCTTATGCCCCAGTTC
AAGCCACTGCAGCTAAGTATTAATCCCCAGTGCTAAAAGATACCAGGCATCTAGTTTAGCAATGGAGGGAAACAGAAACAGCCTGTAGAG
AGCATCGACAAGGCGCATAATGGAGAGTTGGTATCTCAACCCCAAGCTCCCTTTGCTGTACCTGGGCTGCTCTGTGAACAAGAATCCACG
CCCCCCTGCCCTGCTGGGGACCACATAATGATCCCTTTGGGGGAAGTTGCTGATTGCAGGGCAAGCTAGCTTGGTAAGGAAAACCTCTGC
ACCAGCGGCCTATTCCTGCCTCTTGGTCCATAGCCTCATACACTCATGTTGATGGATAGTATAGATTTGCTGCCCACACCAGATATCTGT
AAGGCATCACTGTCCTGATTCTGAACCTCTGTTTCAGGAAGCATTCTCCCCTGTGTAAACAACTCAAGGTGGAAGTATTTCAGAGGGCAT
AGGGTCATGAATCCTTACCCAAAGGAAGCCTGTTTTAGCAGTGGATGCAGGAGTTGATGAACAGACAAGCAAGTTCTGCTTCTGTCCTGT
TTCCTCCTGACAGCTCCATTCTTTTGAAGCCTGACCCTTCCTAAGCTCTGCATCATAACCACTCTGAGAATTGCCCCATTGGGTGGGCAT
GTGAAGCCCAGCTCTGTTCCATCCAGGTGCCTCGGGCCTGAGGAGTCTGAGGATCTGACTTGGGTCTTGGAAGGGTTCCAACCCCAAGTC
AGTCAGGAAGCTGCCCATTTTTTTGCAAGGCATTTTAATGCCCTTTCCCAGACCTCTCTAGTCCCTCCTGCCTTCTGTTCTCTGTAGCTG
TGAGCCCTTTGTGAGAATATGACTCTTAATTTTGAATCTTATGTAAGAGGCTTGAGATGTGCTGGAGAGGGCAGGAAGAGGAAAGTATCA
GGCCTTGAGAGAGGGAATGTAGCTTTGCTTCTATGATCTGGAGTCACCTTCACTTGCTAGCTGAGTCCTAACACAACTTCCAAGTCCATG
ATTCTCTTGGGGCATTGGATGGGCTCAGTGTGGGTCTCTTAGGCTGTTCTTGTGACTTCATCATTTCCTGGTTCAAAGTTGTACTGTCAA

>1550_1550_2_ACSS3-KRT77_ACSS3_chr12_81503483_ENST00000548058_KRT77_chr12_53091680_ENST00000341809_length(amino acids)=606AA_BP=208
MVAPGRFFPATLVWLPNFWALGSLRNLPPPPTPFPQAPGSCKSTICRTLGDRGWPEEMKPSWLQCRKVTSAGGLGGPLPGSSPARGAGAA
LRALVVPGPRGGLGGRGCRALSSGSGSEYKTHFAASVTDPERFWGKAAEQISWYKPWTKTLENKHSPSTRWFVEGMLNICYNAVDRHIEN
GKGDKIAIIYDSPVTNTKATFTYKEVLEQVRFLEQQNQVLQTKWELLQQVNTSTGTNNLEPLLENYIGDLRRQVDLLSAEQMRQNAEVRS
MQDVVEDYKSKYEDEINKRTGSENDFVVLKKDVDAAYVSKVDLESRVDTLTGEVNFLKYLFLTELSQVQTHISDTNVILSMDNNRSLDLD
SIIDAVRTQYELIAQRSKDEAEALYQTKYQELQITAGRHGDDLKNSKMEIAELNRTVQRLQAEISNVKKQIEQMQSLISDAEERGEQALQ
DAWQKLQDLEEALQQSKEELARLLRDYQAMLGVKLSLDVEIATYRQLLEGEESRMSGELQSHVSISVQNSQVSVNGGAGGGGSYGSGGYG

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Fusion Gene PPI Analysis for ACSS3-KRT77


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACSS3-KRT77


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ACSS3-KRT77


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource