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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARMC7-HN1 (FusionGDB2 ID:HG79637TG100462977)

Fusion Gene Summary for ARMC7-HN1

check button Fusion gene summary
Fusion gene informationFusion gene name: ARMC7-HN1
Fusion gene ID: hg79637tg100462977
HgeneTgene
Gene symbol

ARMC7

HN1

Gene ID

79637

100462977

Gene namearmadillo repeat containing 7MT-RNR2 like 1
Synonyms-HN1
Cytomap('ARMC7')('HN1')

17q25.1

17p11.2

Type of geneprotein-codingprotein-coding
Descriptionarmadillo repeat-containing protein 7humanin-like 1MTRNR2-like 1humanin-like protein 1
Modification date2020032720200313
UniProtAcc

Q9H6L4

.
Ensembl transtripts involved in fusion geneENST00000245543, ENST00000582136, 
ENST00000584947, ENST00000579096, 
ENST00000581078, 
ENST00000581078, 
ENST00000579096, ENST00000245543, 
ENST00000582136, ENST00000584947, 
Fusion gene scores* DoF score9 X 3 X 5=13510 X 3 X 6=180
# samples 911
** MAII scorelog2(9/135*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(11/180*10)=-0.710493382805015
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARMC7 [Title/Abstract] AND HN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARMC7(73106701)-HN1(73132345), # samples:3
Anticipated loss of major functional domain due to fusion event.ARMC7-HN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
HN1-ARMC7 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ARMC7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across HN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-39-5028-01AARMC7chr17

73106701

-HN1chr17

73132345

-
ChimerDB4LUSCTCGA-39-5028-01AARMC7chr17

73106701

+HN1chr17

73132345

-
ChimerDB4LUSCTCGA-39-5028ARMC7chr17

73106701

+HN1chr17

73132345

-


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Fusion Gene ORF analysis for ARMC7-HN1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000245543ENST00000581874ARMC7chr17

73106701

+HN1chr17

73132345

-
5CDS-3UTRENST00000582136ENST00000581874ARMC7chr17

73106701

+HN1chr17

73132345

-
5CDS-3UTRENST00000584947ENST00000581874ARMC7chr17

73106701

+HN1chr17

73132345

-
5CDS-intronENST00000245543ENST00000465454ARMC7chr17

73106701

+HN1chr17

73132345

-
5CDS-intronENST00000582136ENST00000465454ARMC7chr17

73106701

+HN1chr17

73132345

-
5CDS-intronENST00000584947ENST00000465454ARMC7chr17

73106701

+HN1chr17

73132345

-
Frame-shiftENST00000245543ENST00000392566ARMC7chr17

73106701

+HN1chr17

73132345

-
Frame-shiftENST00000245543ENST00000409753ARMC7chr17

73106701

+HN1chr17

73132345

-
Frame-shiftENST00000245543ENST00000476258ARMC7chr17

73106701

+HN1chr17

73132345

-
Frame-shiftENST00000245543ENST00000481647ARMC7chr17

73106701

+HN1chr17

73132345

-
Frame-shiftENST00000582136ENST00000392566ARMC7chr17

73106701

+HN1chr17

73132345

-
Frame-shiftENST00000582136ENST00000409753ARMC7chr17

73106701

+HN1chr17

73132345

-
Frame-shiftENST00000582136ENST00000476258ARMC7chr17

73106701

+HN1chr17

73132345

-
Frame-shiftENST00000582136ENST00000481647ARMC7chr17

73106701

+HN1chr17

73132345

-
Frame-shiftENST00000584947ENST00000392566ARMC7chr17

73106701

+HN1chr17

73132345

-
Frame-shiftENST00000584947ENST00000409753ARMC7chr17

73106701

+HN1chr17

73132345

-
Frame-shiftENST00000584947ENST00000476258ARMC7chr17

73106701

+HN1chr17

73132345

-
Frame-shiftENST00000584947ENST00000481647ARMC7chr17

73106701

+HN1chr17

73132345

-
In-frameENST00000245543ENST00000356033ARMC7chr17

73106701

+HN1chr17

73132345

-
In-frameENST00000245543ENST00000405458ARMC7chr17

73106701

+HN1chr17

73132345

-
In-frameENST00000245543ENST00000470924ARMC7chr17

73106701

+HN1chr17

73132345

-
In-frameENST00000245543ENST00000482348ARMC7chr17

73106701

+HN1chr17

73132345

-
In-frameENST00000582136ENST00000356033ARMC7chr17

73106701

+HN1chr17

73132345

-
In-frameENST00000582136ENST00000405458ARMC7chr17

73106701

+HN1chr17

73132345

-
In-frameENST00000582136ENST00000470924ARMC7chr17

73106701

+HN1chr17

73132345

-
In-frameENST00000582136ENST00000482348ARMC7chr17

73106701

+HN1chr17

73132345

-
In-frameENST00000584947ENST00000356033ARMC7chr17

73106701

+HN1chr17

73132345

-
In-frameENST00000584947ENST00000405458ARMC7chr17

73106701

+HN1chr17

73132345

-
In-frameENST00000584947ENST00000470924ARMC7chr17

73106701

+HN1chr17

73132345

-
In-frameENST00000584947ENST00000482348ARMC7chr17

73106701

+HN1chr17

73132345

-
intron-3CDSENST00000579096ENST00000356033ARMC7chr17

73106701

+HN1chr17

73132345

-
intron-3CDSENST00000579096ENST00000392566ARMC7chr17

73106701

+HN1chr17

73132345

-
intron-3CDSENST00000579096ENST00000405458ARMC7chr17

73106701

+HN1chr17

73132345

-
intron-3CDSENST00000579096ENST00000409753ARMC7chr17

73106701

+HN1chr17

73132345

-
intron-3CDSENST00000579096ENST00000470924ARMC7chr17

73106701

+HN1chr17

73132345

-
intron-3CDSENST00000579096ENST00000476258ARMC7chr17

73106701

+HN1chr17

73132345

-
intron-3CDSENST00000579096ENST00000481647ARMC7chr17

73106701

+HN1chr17

73132345

-
intron-3CDSENST00000579096ENST00000482348ARMC7chr17

73106701

+HN1chr17

73132345

-
intron-3CDSENST00000581078ENST00000356033ARMC7chr17

73106701

+HN1chr17

73132345

-
intron-3CDSENST00000581078ENST00000392566ARMC7chr17

73106701

+HN1chr17

73132345

-
intron-3CDSENST00000581078ENST00000405458ARMC7chr17

73106701

+HN1chr17

73132345

-
intron-3CDSENST00000581078ENST00000409753ARMC7chr17

73106701

+HN1chr17

73132345

-
intron-3CDSENST00000581078ENST00000470924ARMC7chr17

73106701

+HN1chr17

73132345

-
intron-3CDSENST00000581078ENST00000476258ARMC7chr17

73106701

+HN1chr17

73132345

-
intron-3CDSENST00000581078ENST00000481647ARMC7chr17

73106701

+HN1chr17

73132345

-
intron-3CDSENST00000581078ENST00000482348ARMC7chr17

73106701

+HN1chr17

73132345

-
intron-3UTRENST00000579096ENST00000581874ARMC7chr17

73106701

+HN1chr17

73132345

-
intron-3UTRENST00000581078ENST00000581874ARMC7chr17

73106701

+HN1chr17

73132345

-
intron-intronENST00000579096ENST00000465454ARMC7chr17

73106701

+HN1chr17

73132345

-
intron-intronENST00000581078ENST00000465454ARMC7chr17

73106701

+HN1chr17

73132345

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ARMC7-HN1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ARMC7-HN1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:73106701/chr17:73132345)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARMC7

Q9H6L4

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARMC7chr17:73106701chr17:73132345ENST00000245543+23100_14078199.0RepeatNote=ARM 2
HgeneARMC7chr17:73106701chr17:73132345ENST00000245543+2357_9978199.0RepeatNote=ARM 1


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Fusion Gene Sequence for ARMC7-HN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ARMC7-HN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARMC7-HN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARMC7-HN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource