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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AKIRIN1-MEAF6 (FusionGDB2 ID:HG79647TG64769)

Fusion Gene Summary for AKIRIN1-MEAF6

check button Fusion gene summary
Fusion gene informationFusion gene name: AKIRIN1-MEAF6
Fusion gene ID: hg79647tg64769
HgeneTgene
Gene symbol

AKIRIN1

MEAF6

Gene ID

79647

64769

Gene nameakirin 1MYST/Esa1 associated factor 6
SynonymsC1orf108|STRF2C1orf149|CENP-28|EAF6|NY-SAR-91
Cytomap('AKIRIN1')('MEAF6')

1p34.3

1p34.3

Type of geneprotein-codingprotein-coding
Descriptionakirin-1chromatin modification-related protein MEAF6Esa1p-associated factor 6 homologcentromere protein 28protein EAF6 homologsarcoma antigen NY-SAR-91
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000432648, ENST00000446189, 
ENST00000372984, 
Fusion gene scores* DoF score4 X 4 X 2=326 X 5 X 5=150
# samples 46
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AKIRIN1 [Title/Abstract] AND MEAF6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAKIRIN1(39463983)-MEAF6(37967597), # samples:4
Anticipated loss of major functional domain due to fusion event.AKIRIN1-MEAF6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AKIRIN1-MEAF6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMEAF6

GO:0043968

histone H2A acetylation

14966270

TgeneMEAF6

GO:0043981

histone H4-K5 acetylation

16387653

TgeneMEAF6

GO:0043982

histone H4-K8 acetylation

16387653

TgeneMEAF6

GO:0043983

histone H4-K12 acetylation

16387653

TgeneMEAF6

GO:0043984

histone H4-K16 acetylation

16387653

TgeneMEAF6

GO:0044154

histone H3-K14 acetylation

16387653


check buttonFusion gene breakpoints across AKIRIN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across MEAF6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-55-6712-01AAKIRIN1chr1

39463983

-MEAF6chr1

37967597

-
ChimerDB4LUADTCGA-55-6712-01AAKIRIN1chr1

39463983

+MEAF6chr1

37967597

-
ChimerDB4LUADTCGA-55-6712AKIRIN1chr1

39463983

+MEAF6chr1

37967597

-


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Fusion Gene ORF analysis for AKIRIN1-MEAF6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000432648ENST00000373073AKIRIN1chr1

39463983

+MEAF6chr1

37967597

-
5CDS-5UTRENST00000432648ENST00000448519AKIRIN1chr1

39463983

+MEAF6chr1

37967597

-
5CDS-5UTRENST00000432648ENST00000475828AKIRIN1chr1

39463983

+MEAF6chr1

37967597

-
5CDS-5UTRENST00000446189ENST00000373073AKIRIN1chr1

39463983

+MEAF6chr1

37967597

-
5CDS-5UTRENST00000446189ENST00000448519AKIRIN1chr1

39463983

+MEAF6chr1

37967597

-
5CDS-5UTRENST00000446189ENST00000475828AKIRIN1chr1

39463983

+MEAF6chr1

37967597

-
In-frameENST00000432648ENST00000296214AKIRIN1chr1

39463983

+MEAF6chr1

37967597

-
In-frameENST00000432648ENST00000373074AKIRIN1chr1

39463983

+MEAF6chr1

37967597

-
In-frameENST00000432648ENST00000373075AKIRIN1chr1

39463983

+MEAF6chr1

37967597

-
In-frameENST00000446189ENST00000296214AKIRIN1chr1

39463983

+MEAF6chr1

37967597

-
In-frameENST00000446189ENST00000373074AKIRIN1chr1

39463983

+MEAF6chr1

37967597

-
In-frameENST00000446189ENST00000373075AKIRIN1chr1

39463983

+MEAF6chr1

37967597

-
intron-3CDSENST00000372984ENST00000296214AKIRIN1chr1

39463983

+MEAF6chr1

37967597

-
intron-3CDSENST00000372984ENST00000373074AKIRIN1chr1

39463983

+MEAF6chr1

37967597

-
intron-3CDSENST00000372984ENST00000373075AKIRIN1chr1

39463983

+MEAF6chr1

37967597

-
intron-5UTRENST00000372984ENST00000373073AKIRIN1chr1

39463983

+MEAF6chr1

37967597

-
intron-5UTRENST00000372984ENST00000448519AKIRIN1chr1

39463983

+MEAF6chr1

37967597

-
intron-5UTRENST00000372984ENST00000475828AKIRIN1chr1

39463983

+MEAF6chr1

37967597

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000432648AKIRIN1chr139463983+ENST00000373075MEAF6chr137967597-2309519158784208
ENST00000432648AKIRIN1chr139463983+ENST00000296214MEAF6chr137967597-1676519158754198
ENST00000432648AKIRIN1chr139463983+ENST00000373074MEAF6chr137967597-1543519158754198
ENST00000446189AKIRIN1chr139463983+ENST00000373075MEAF6chr137967597-224445493719208
ENST00000446189AKIRIN1chr139463983+ENST00000296214MEAF6chr137967597-161145493689198
ENST00000446189AKIRIN1chr139463983+ENST00000373074MEAF6chr137967597-147845493689198

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000432648ENST00000373075AKIRIN1chr139463983+MEAF6chr137967597-0.0032649050.99673504
ENST00000432648ENST00000296214AKIRIN1chr139463983+MEAF6chr137967597-0.0081590260.99184096
ENST00000432648ENST00000373074AKIRIN1chr139463983+MEAF6chr137967597-0.0095095290.99049044
ENST00000446189ENST00000373075AKIRIN1chr139463983+MEAF6chr137967597-0.0038697210.9961302
ENST00000446189ENST00000296214AKIRIN1chr139463983+MEAF6chr137967597-0.0106025520.9893974
ENST00000446189ENST00000373074AKIRIN1chr139463983+MEAF6chr137967597-0.0127966140.9872034

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Fusion Genomic Features for AKIRIN1-MEAF6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for AKIRIN1-MEAF6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:39463983/chr1:37967597)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAKIRIN1chr1:39463983chr1:37967597ENST00000432648+2520_73120193.0Compositional biasNote=Pro-rich
HgeneAKIRIN1chr1:39463983chr1:37967597ENST00000446189+2420_73120148.0Compositional biasNote=Pro-rich
HgeneAKIRIN1chr1:39463983chr1:37967597ENST00000432648+2523_28120193.0MotifNote=Nuclear localization signal
HgeneAKIRIN1chr1:39463983chr1:37967597ENST00000446189+2423_28120148.0MotifNote=Nuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMEAF6chr1:39463983chr1:37967597ENST000002962143711_47113192.0Coiled coilOntology_term=ECO:0000255
TgeneMEAF6chr1:39463983chr1:37967597ENST000003730733611_47113193.0Coiled coilOntology_term=ECO:0000255
TgeneMEAF6chr1:39463983chr1:37967597ENST000003730753811_47113202.0Coiled coilOntology_term=ECO:0000255
TgeneMEAF6chr1:39463983chr1:37967597ENST000004485193811_47113157.66666666666666Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for AKIRIN1-MEAF6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>3412_3412_1_AKIRIN1-MEAF6_AKIRIN1_chr1_39463983_ENST00000432648_MEAF6_chr1_37967597_ENST00000296214_length(transcript)=1676nt_BP=519nt
GATGGTGTGCGCCCGTGACGTCACAGAAGGCGGGGCCAGCGCCGCTGCCGGGTGCTGGAGGCGCCATTGGAGCCGGCTTGGCTGGCGAGC
CCGGCTGAGGAGCCTCTTGGGCCGCACTTACCGCCGCGTCCGCTCCCGGTCCCTGGCCCCTCAGCGGCATGGCGTGCGGGGCGACGCTGA
AGCGGCCCATGGAGTTCGAGGCGGCGCTGCTGAGCCCCGGCTCCCCGAAGCGGCGGCGCTGCGCCCCTCTGCCCGGCCCCACTCCGGGCC
TCAGGCCCCCGGACGCCGAGCCGCCGCCGCCGTTTCAGACGCAGACCCCACCGCAGAGTCTGCAGCAGCCCGCCCCGCCCGGCAGCGAGC
GGCGCCTTCCAACTCCGGAGCAAATTTTTCAGAACATAAAACAAGAATATAGTCGTTATCAGAGGTGGAGACATTTAGAAGTTGTTCTTA
ATCAGAGTGAAGCTTGTGCTTCGGAAAGTCAACCTCACTCCTCAGCACTCACAGCACCTAGCTCTCCAGGGGAGCCAGGAAGTGGGACGG
AAAGTGACACTTCTCCAGACTTCCACAATCAGGAAAATGAGCCCAGCCAGGAGGACCCTGAGGATCTGGATGGATCTGTGCAGGGAGTGA
AACCTCAGAAGGCTGCTTCTTCTACTTCCTCAGGGAGTCACCACAGCAGCCATAAAAAGCGAAAGAATAAAAACCGGCACAGGATTGATC
TGAAGTTAAACAAAAAACCACGAGCTGACTATTAGAAGACACATTAGTGCAGAAGCTTCCAGGCTGTAGAGCCCTGCTTCCCTTCTCTGA
CCTCACAAAGATAAACATCCTTCACCTGAGTTCGTGGCCATCCACCTCTGCTCTCCCAGACCCAGTGCCTGTGACTTTGAGTAGTTTGTT
CTAAATGTGGTGACAAACAAGTCATTTCTGTAAGACATTGGGTCTTACTTTATGTCATTTTTAGTAACAGAACTGCAGGAAGATGAAGAC
AATGTTGTAATCCCAGCAAGTTGCTAACTGTGCGTTTCTCCCTTCTTAGAATGAATGTCTCCCCCAAAACTGGCTGGCACCAGCTTCATC
TGTGATACCCTTCAAGAAATGTTCTCTGGTTTTGTTTTATGCTGAAAGTAGAACACAAGTCACATTTCAGATGGAGGCTGTAAATATCTG
GCATTTTCTTATATTGTTTTATGTTTTCTTGTTTTTCTCTTGTTGTTTTTATCTTATTTTCTTTGGGGTTTTTTTGTAATGCCTTTGTAC
AGCTCATACTTTCCTGCTGACATATCTGATCATCTCTTTCATGCAGTTGCCAATATTCATAACTGAAAATAATCTGGTTTATCATAAGTA
AAATGGGAAACTTGCCTCTGTTTTTTGCAAGGGGAGGTAAAGAGTGTTTAGTAATTACCTATCTTAAATCTTTCTGAGTTGGTAGTAGAT
TCATGTTCAAGGAACAGGAAAAATGGAAAAACATAAGTTTAAATCAGTTCTTTTTAAATAACTTTTTATTCTTTTGTATAAATAAAATTT
CACAGGCTTCAAATTCTCATGCTTTACTTTTAAACCCGAGATTGTTTTTTCACTTATTTATTCATATCATGCCTTATGGAAATTTCTTTT
TCTGTATTTTCTCTCTTTGCTGGTATTCACCTGATTAAATATTGCTCTAAAAATCA

>3412_3412_1_AKIRIN1-MEAF6_AKIRIN1_chr1_39463983_ENST00000432648_MEAF6_chr1_37967597_ENST00000296214_length(amino acids)=198AA_BP=108
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRW
RHLEVVLNQSEACASESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDLDGSVQGVKPQKAASSTSSGSHHSSHKKRKN
KNRHRIDLKLNKKPRADY

--------------------------------------------------------------
>3412_3412_2_AKIRIN1-MEAF6_AKIRIN1_chr1_39463983_ENST00000432648_MEAF6_chr1_37967597_ENST00000373074_length(transcript)=1543nt_BP=519nt
GATGGTGTGCGCCCGTGACGTCACAGAAGGCGGGGCCAGCGCCGCTGCCGGGTGCTGGAGGCGCCATTGGAGCCGGCTTGGCTGGCGAGC
CCGGCTGAGGAGCCTCTTGGGCCGCACTTACCGCCGCGTCCGCTCCCGGTCCCTGGCCCCTCAGCGGCATGGCGTGCGGGGCGACGCTGA
AGCGGCCCATGGAGTTCGAGGCGGCGCTGCTGAGCCCCGGCTCCCCGAAGCGGCGGCGCTGCGCCCCTCTGCCCGGCCCCACTCCGGGCC
TCAGGCCCCCGGACGCCGAGCCGCCGCCGCCGTTTCAGACGCAGACCCCACCGCAGAGTCTGCAGCAGCCCGCCCCGCCCGGCAGCGAGC
GGCGCCTTCCAACTCCGGAGCAAATTTTTCAGAACATAAAACAAGAATATAGTCGTTATCAGAGGTGGAGACATTTAGAAGTTGTTCTTA
ATCAGAGTGAAGCTTGTGCTTCGGAAAGTCAACCTCACTCCTCAGCACTCACAGCACCTAGCTCTCCAGGGGAGCCAGGAAGTGGGACGG
AAAGTGACACTTCTCCAGACTTCCACAATCAGGAAAATGAGCCCAGCCAGGAGGACCCTGAGGATCTGGATGGATCTGTGCAGGGAGTGA
AACCTCAGAAGGCTGCTTCTTCTACTTCCTCAGGGAGTCACCACAGCAGCCATAAAAAGCGAAAGAATAAAAACCGGCACAGGATTGATC
TGAAGTTAAACAAAAAACCACGAGCTGACTATTAGAAGACACATTAGTGCAGAAGCTTCCAGGCTGTAGAGCCCTGCTTCCCTTCTCTGA
CCTCACAAAGATAAACATCCTTCACCTGAGTTCGTGGCCATCCACCTCTGCTCTCCCAGACCCAGTGCCTGTGACTTTGAGTAGTTTGTT
CTAAATGTGGTGACAAACAAGTCATTTCTGTAAGACATTGGGTCTTACTTTATGTCATTTTTAGTAACAGAACTGCAGGAAGATGAAGAC
AATGTTGTAATCCCAGCAAGTTGCTAACTGTGCGTTTCTCCCTTCTTAGAATGAATGTCTCCCCCAAAACTGGCTGGCACCAGCTTCATC
TGTGATACCCTTCAAGAAATGTTCTCTGGTTTTGTTTTATGCTGAAAGTAGAACACAAGTCACATTTCAGATGGAGGCTGTAAATATCTG
GCATTTTCTTATATTGTTTTATGTTTTCTTGTTTTTCTCTTGTTGTTTTTATCTTATTTTCTTTGGGGTTTTTTTGTAATGCCTTTGTAC
AGCTCATACTTTCCTGCTGACATATCTGATCATCTCTTTCATGCAGTTGCCAATATTCATAACTGAAAATAATCTGGTTTATCATAAGTA
AAATGGGAAACTTGCCTCTGTTTTTTGCAAGGGGAGGTAAAGAGTGTTTAGTAATTACCTATCTTAAATCTTTCTGAGTTGGTAGTAGAT
TCATGTTCAAGGAACAGGAAAAATGGAAAAACATAAGTTTAAATCAGTTCTTTTTAAATAACTTTTTATTCTTTTGTATAAATAAAATTT
CACAGGCTTCAAA

>3412_3412_2_AKIRIN1-MEAF6_AKIRIN1_chr1_39463983_ENST00000432648_MEAF6_chr1_37967597_ENST00000373074_length(amino acids)=198AA_BP=108
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRW
RHLEVVLNQSEACASESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDLDGSVQGVKPQKAASSTSSGSHHSSHKKRKN
KNRHRIDLKLNKKPRADY

--------------------------------------------------------------
>3412_3412_3_AKIRIN1-MEAF6_AKIRIN1_chr1_39463983_ENST00000432648_MEAF6_chr1_37967597_ENST00000373075_length(transcript)=2309nt_BP=519nt
GATGGTGTGCGCCCGTGACGTCACAGAAGGCGGGGCCAGCGCCGCTGCCGGGTGCTGGAGGCGCCATTGGAGCCGGCTTGGCTGGCGAGC
CCGGCTGAGGAGCCTCTTGGGCCGCACTTACCGCCGCGTCCGCTCCCGGTCCCTGGCCCCTCAGCGGCATGGCGTGCGGGGCGACGCTGA
AGCGGCCCATGGAGTTCGAGGCGGCGCTGCTGAGCCCCGGCTCCCCGAAGCGGCGGCGCTGCGCCCCTCTGCCCGGCCCCACTCCGGGCC
TCAGGCCCCCGGACGCCGAGCCGCCGCCGCCGTTTCAGACGCAGACCCCACCGCAGAGTCTGCAGCAGCCCGCCCCGCCCGGCAGCGAGC
GGCGCCTTCCAACTCCGGAGCAAATTTTTCAGAACATAAAACAAGAATATAGTCGTTATCAGAGGTGGAGACATTTAGAAGTTGTTCTTA
ATCAGAGTGAAGCTTGTGCTTCGGAAAGTCAACCTCACTCCTCAGCACTCACAGCACCTAGCTCTCCAGGGGAGCCAGGAAGTGGGACGG
AAAGTGACACTTCTCCAGACTTCCACAATCAGGAAAATGAGCCCAGCCAGGAGGACCCTGAGGATCTGGATGGATCTGTGCAGGGAGTGA
AACCTCAGAAGGCTGCTTCTTCTACTTCCTCAGGGAGTCACCACAGCAGCCATAAAAAGCGAAAGAATAAAAACCGGCACAGCCCGTCTG
GCATGTTTGATTATGACTTTGAGATTGATCTGAAGTTAAACAAAAAACCACGAGCTGACTATTAGAAGACACATTAGTGCAGAAGCTTCC
AGGCTGTAGAGCCCTGCTTCCCTTCTCTGACCTCACAAAGATAAACATCCTTCACCTGAGTTCGTGGCCATCCACCTCTGCTCTCCCAGA
CCCAGTGCCTGTGACTTTGAGTAGTTTGTTCTAAATGTGGTGACAAACAAGTCATTTCTGTAAGACATTGGGTCTTACTTTATGTCATTT
TTAGTAACAGAACTGCAGGAAGATGAAGACAATGTTGTAATCCCAGCAAGTTGCTAACTGTGCGTTTCTCCCTTCTTAGAATGAATGTCT
CCCCCAAAACTGGCTGGCACCAGCTTCATCTGTGATACCCTTCAAGAAATGTTCTCTGGTTTTGTTTTATGCTGAAAGTAGAACACAAGT
CACATTTCAGATGGAGGCTGTAAATATCTGGCATTTTCTTATATTGTTTTATGTTTTCTTGTTTTTCTCTTGTTGTTTTTATCTTATTTT
CTTTGGGGTTTTTTTGTAATGCCTTTGTACAGCTCATACTTTCCTGCTGACATATCTGATCATCTCTTTCATGCAGTTGCCAATATTCAT
AACTGAAAATAATCTGGTTTATCATAAGTAAAATGGGAAACTTGCCTCTGTTTTTTGCAAGGGGAGGTAAAGAGTGTTTAGTAATTACCT
ATCTTAAATCTTTCTGAGTTGGTAGTAGATTCATGTTCAAGGAACAGGAAAAATGGAAAAACATAAGTTTAAATCAGTTCTTTTTAAATA
ACTTTTTATTCTTTTGTATAAATAAAATTTCACAGGCTTCAAATTCTCATGCTTTACTTTTAAACCCGAGATTGTTTTTTCACTTATTTA
TTCATATCATGCCTTATGGAAATTTCTTTTTCTGTATTTTCTCTCTTTGCTGGTATTCACCTGATTAAATATTGCTCTAAAAATCACCAT
GGCATATGGAAAGTCTCAAAATTATACCAAAAGTGATAACTTATGTCGTTCTTAAGTGGAGTGAAAGGATAGCATCAGTGAGAGCCAGTG
TTGCCCACCAGGTCTCCCTTTCTTGGAGGGCTTGTTGGGGCTGAGGAATCTGCTAGTAATCGTTACCTGCCTCTAGTGCTGTGGTGAACT
TGCGACAGGGTCTGGCTGCACATTGGAATCACCTGAGAAGCTTTAAAATACTCATGCCTGGATCCCATCCCTAGAGACTGGGGTACAGCC
TAGTTATTGGGAATTTCTTTAAAAGAGTTCCTGGGATTCTGATAAGAAGCCAGGTTGAGAACCACTACATTAGAAGACTGAATGGTTTAA
TTTACATCCTATGTTATGATTGGTCTAAGGGATAAGATTTGGGGTCTAACCTTTCCTTTCACTCTAGTTAGTCATAGTCCTTGACTTATG
CCTATATCTTTGTAAGAAATAGTATGTTTCATTTGTGATAGTATTGGTAGGGCTGAATATGGATGGCATCTACTGTAAAACAAGTCTACC
TTGTCAGATGTGCAAAAGCTTTCACTCTTGTTCTCAAATAAACTTTTGTGGGTTTTTTT

>3412_3412_3_AKIRIN1-MEAF6_AKIRIN1_chr1_39463983_ENST00000432648_MEAF6_chr1_37967597_ENST00000373075_length(amino acids)=208AA_BP=108
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRW
RHLEVVLNQSEACASESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDLDGSVQGVKPQKAASSTSSGSHHSSHKKRKN
KNRHSPSGMFDYDFEIDLKLNKKPRADY

--------------------------------------------------------------
>3412_3412_4_AKIRIN1-MEAF6_AKIRIN1_chr1_39463983_ENST00000446189_MEAF6_chr1_37967597_ENST00000296214_length(transcript)=1611nt_BP=454nt
ATTGGAGCCGGCTTGGCTGGCGAGCCCGGCTGAGGAGCCTCTTGGGCCGCACTTACCGCCGCGTCCGCTCCCGGTCCCTGGCCCCTCAGC
GGCATGGCGTGCGGGGCGACGCTGAAGCGGCCCATGGAGTTCGAGGCGGCGCTGCTGAGCCCCGGCTCCCCGAAGCGGCGGCGCTGCGCC
CCTCTGCCCGGCCCCACTCCGGGCCTCAGGCCCCCGGACGCCGAGCCGCCGCCGCCGTTTCAGACGCAGACCCCACCGCAGAGTCTGCAG
CAGCCCGCCCCGCCCGGCAGCGAGCGGCGCCTTCCAACTCCGGAGCAAATTTTTCAGAACATAAAACAAGAATATAGTCGTTATCAGAGG
TGGAGACATTTAGAAGTTGTTCTTAATCAGAGTGAAGCTTGTGCTTCGGAAAGTCAACCTCACTCCTCAGCACTCACAGCACCTAGCTCT
CCAGGGGAGCCAGGAAGTGGGACGGAAAGTGACACTTCTCCAGACTTCCACAATCAGGAAAATGAGCCCAGCCAGGAGGACCCTGAGGAT
CTGGATGGATCTGTGCAGGGAGTGAAACCTCAGAAGGCTGCTTCTTCTACTTCCTCAGGGAGTCACCACAGCAGCCATAAAAAGCGAAAG
AATAAAAACCGGCACAGGATTGATCTGAAGTTAAACAAAAAACCACGAGCTGACTATTAGAAGACACATTAGTGCAGAAGCTTCCAGGCT
GTAGAGCCCTGCTTCCCTTCTCTGACCTCACAAAGATAAACATCCTTCACCTGAGTTCGTGGCCATCCACCTCTGCTCTCCCAGACCCAG
TGCCTGTGACTTTGAGTAGTTTGTTCTAAATGTGGTGACAAACAAGTCATTTCTGTAAGACATTGGGTCTTACTTTATGTCATTTTTAGT
AACAGAACTGCAGGAAGATGAAGACAATGTTGTAATCCCAGCAAGTTGCTAACTGTGCGTTTCTCCCTTCTTAGAATGAATGTCTCCCCC
AAAACTGGCTGGCACCAGCTTCATCTGTGATACCCTTCAAGAAATGTTCTCTGGTTTTGTTTTATGCTGAAAGTAGAACACAAGTCACAT
TTCAGATGGAGGCTGTAAATATCTGGCATTTTCTTATATTGTTTTATGTTTTCTTGTTTTTCTCTTGTTGTTTTTATCTTATTTTCTTTG
GGGTTTTTTTGTAATGCCTTTGTACAGCTCATACTTTCCTGCTGACATATCTGATCATCTCTTTCATGCAGTTGCCAATATTCATAACTG
AAAATAATCTGGTTTATCATAAGTAAAATGGGAAACTTGCCTCTGTTTTTTGCAAGGGGAGGTAAAGAGTGTTTAGTAATTACCTATCTT
AAATCTTTCTGAGTTGGTAGTAGATTCATGTTCAAGGAACAGGAAAAATGGAAAAACATAAGTTTAAATCAGTTCTTTTTAAATAACTTT
TTATTCTTTTGTATAAATAAAATTTCACAGGCTTCAAATTCTCATGCTTTACTTTTAAACCCGAGATTGTTTTTTCACTTATTTATTCAT
ATCATGCCTTATGGAAATTTCTTTTTCTGTATTTTCTCTCTTTGCTGGTATTCACCTGATTAAATATTGCTCTAAAAATCA

>3412_3412_4_AKIRIN1-MEAF6_AKIRIN1_chr1_39463983_ENST00000446189_MEAF6_chr1_37967597_ENST00000296214_length(amino acids)=198AA_BP=108
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRW
RHLEVVLNQSEACASESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDLDGSVQGVKPQKAASSTSSGSHHSSHKKRKN
KNRHRIDLKLNKKPRADY

--------------------------------------------------------------
>3412_3412_5_AKIRIN1-MEAF6_AKIRIN1_chr1_39463983_ENST00000446189_MEAF6_chr1_37967597_ENST00000373074_length(transcript)=1478nt_BP=454nt
ATTGGAGCCGGCTTGGCTGGCGAGCCCGGCTGAGGAGCCTCTTGGGCCGCACTTACCGCCGCGTCCGCTCCCGGTCCCTGGCCCCTCAGC
GGCATGGCGTGCGGGGCGACGCTGAAGCGGCCCATGGAGTTCGAGGCGGCGCTGCTGAGCCCCGGCTCCCCGAAGCGGCGGCGCTGCGCC
CCTCTGCCCGGCCCCACTCCGGGCCTCAGGCCCCCGGACGCCGAGCCGCCGCCGCCGTTTCAGACGCAGACCCCACCGCAGAGTCTGCAG
CAGCCCGCCCCGCCCGGCAGCGAGCGGCGCCTTCCAACTCCGGAGCAAATTTTTCAGAACATAAAACAAGAATATAGTCGTTATCAGAGG
TGGAGACATTTAGAAGTTGTTCTTAATCAGAGTGAAGCTTGTGCTTCGGAAAGTCAACCTCACTCCTCAGCACTCACAGCACCTAGCTCT
CCAGGGGAGCCAGGAAGTGGGACGGAAAGTGACACTTCTCCAGACTTCCACAATCAGGAAAATGAGCCCAGCCAGGAGGACCCTGAGGAT
CTGGATGGATCTGTGCAGGGAGTGAAACCTCAGAAGGCTGCTTCTTCTACTTCCTCAGGGAGTCACCACAGCAGCCATAAAAAGCGAAAG
AATAAAAACCGGCACAGGATTGATCTGAAGTTAAACAAAAAACCACGAGCTGACTATTAGAAGACACATTAGTGCAGAAGCTTCCAGGCT
GTAGAGCCCTGCTTCCCTTCTCTGACCTCACAAAGATAAACATCCTTCACCTGAGTTCGTGGCCATCCACCTCTGCTCTCCCAGACCCAG
TGCCTGTGACTTTGAGTAGTTTGTTCTAAATGTGGTGACAAACAAGTCATTTCTGTAAGACATTGGGTCTTACTTTATGTCATTTTTAGT
AACAGAACTGCAGGAAGATGAAGACAATGTTGTAATCCCAGCAAGTTGCTAACTGTGCGTTTCTCCCTTCTTAGAATGAATGTCTCCCCC
AAAACTGGCTGGCACCAGCTTCATCTGTGATACCCTTCAAGAAATGTTCTCTGGTTTTGTTTTATGCTGAAAGTAGAACACAAGTCACAT
TTCAGATGGAGGCTGTAAATATCTGGCATTTTCTTATATTGTTTTATGTTTTCTTGTTTTTCTCTTGTTGTTTTTATCTTATTTTCTTTG
GGGTTTTTTTGTAATGCCTTTGTACAGCTCATACTTTCCTGCTGACATATCTGATCATCTCTTTCATGCAGTTGCCAATATTCATAACTG
AAAATAATCTGGTTTATCATAAGTAAAATGGGAAACTTGCCTCTGTTTTTTGCAAGGGGAGGTAAAGAGTGTTTAGTAATTACCTATCTT
AAATCTTTCTGAGTTGGTAGTAGATTCATGTTCAAGGAACAGGAAAAATGGAAAAACATAAGTTTAAATCAGTTCTTTTTAAATAACTTT
TTATTCTTTTGTATAAATAAAATTTCACAGGCTTCAAA

>3412_3412_5_AKIRIN1-MEAF6_AKIRIN1_chr1_39463983_ENST00000446189_MEAF6_chr1_37967597_ENST00000373074_length(amino acids)=198AA_BP=108
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRW
RHLEVVLNQSEACASESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDLDGSVQGVKPQKAASSTSSGSHHSSHKKRKN
KNRHRIDLKLNKKPRADY

--------------------------------------------------------------
>3412_3412_6_AKIRIN1-MEAF6_AKIRIN1_chr1_39463983_ENST00000446189_MEAF6_chr1_37967597_ENST00000373075_length(transcript)=2244nt_BP=454nt
ATTGGAGCCGGCTTGGCTGGCGAGCCCGGCTGAGGAGCCTCTTGGGCCGCACTTACCGCCGCGTCCGCTCCCGGTCCCTGGCCCCTCAGC
GGCATGGCGTGCGGGGCGACGCTGAAGCGGCCCATGGAGTTCGAGGCGGCGCTGCTGAGCCCCGGCTCCCCGAAGCGGCGGCGCTGCGCC
CCTCTGCCCGGCCCCACTCCGGGCCTCAGGCCCCCGGACGCCGAGCCGCCGCCGCCGTTTCAGACGCAGACCCCACCGCAGAGTCTGCAG
CAGCCCGCCCCGCCCGGCAGCGAGCGGCGCCTTCCAACTCCGGAGCAAATTTTTCAGAACATAAAACAAGAATATAGTCGTTATCAGAGG
TGGAGACATTTAGAAGTTGTTCTTAATCAGAGTGAAGCTTGTGCTTCGGAAAGTCAACCTCACTCCTCAGCACTCACAGCACCTAGCTCT
CCAGGGGAGCCAGGAAGTGGGACGGAAAGTGACACTTCTCCAGACTTCCACAATCAGGAAAATGAGCCCAGCCAGGAGGACCCTGAGGAT
CTGGATGGATCTGTGCAGGGAGTGAAACCTCAGAAGGCTGCTTCTTCTACTTCCTCAGGGAGTCACCACAGCAGCCATAAAAAGCGAAAG
AATAAAAACCGGCACAGCCCGTCTGGCATGTTTGATTATGACTTTGAGATTGATCTGAAGTTAAACAAAAAACCACGAGCTGACTATTAG
AAGACACATTAGTGCAGAAGCTTCCAGGCTGTAGAGCCCTGCTTCCCTTCTCTGACCTCACAAAGATAAACATCCTTCACCTGAGTTCGT
GGCCATCCACCTCTGCTCTCCCAGACCCAGTGCCTGTGACTTTGAGTAGTTTGTTCTAAATGTGGTGACAAACAAGTCATTTCTGTAAGA
CATTGGGTCTTACTTTATGTCATTTTTAGTAACAGAACTGCAGGAAGATGAAGACAATGTTGTAATCCCAGCAAGTTGCTAACTGTGCGT
TTCTCCCTTCTTAGAATGAATGTCTCCCCCAAAACTGGCTGGCACCAGCTTCATCTGTGATACCCTTCAAGAAATGTTCTCTGGTTTTGT
TTTATGCTGAAAGTAGAACACAAGTCACATTTCAGATGGAGGCTGTAAATATCTGGCATTTTCTTATATTGTTTTATGTTTTCTTGTTTT
TCTCTTGTTGTTTTTATCTTATTTTCTTTGGGGTTTTTTTGTAATGCCTTTGTACAGCTCATACTTTCCTGCTGACATATCTGATCATCT
CTTTCATGCAGTTGCCAATATTCATAACTGAAAATAATCTGGTTTATCATAAGTAAAATGGGAAACTTGCCTCTGTTTTTTGCAAGGGGA
GGTAAAGAGTGTTTAGTAATTACCTATCTTAAATCTTTCTGAGTTGGTAGTAGATTCATGTTCAAGGAACAGGAAAAATGGAAAAACATA
AGTTTAAATCAGTTCTTTTTAAATAACTTTTTATTCTTTTGTATAAATAAAATTTCACAGGCTTCAAATTCTCATGCTTTACTTTTAAAC
CCGAGATTGTTTTTTCACTTATTTATTCATATCATGCCTTATGGAAATTTCTTTTTCTGTATTTTCTCTCTTTGCTGGTATTCACCTGAT
TAAATATTGCTCTAAAAATCACCATGGCATATGGAAAGTCTCAAAATTATACCAAAAGTGATAACTTATGTCGTTCTTAAGTGGAGTGAA
AGGATAGCATCAGTGAGAGCCAGTGTTGCCCACCAGGTCTCCCTTTCTTGGAGGGCTTGTTGGGGCTGAGGAATCTGCTAGTAATCGTTA
CCTGCCTCTAGTGCTGTGGTGAACTTGCGACAGGGTCTGGCTGCACATTGGAATCACCTGAGAAGCTTTAAAATACTCATGCCTGGATCC
CATCCCTAGAGACTGGGGTACAGCCTAGTTATTGGGAATTTCTTTAAAAGAGTTCCTGGGATTCTGATAAGAAGCCAGGTTGAGAACCAC
TACATTAGAAGACTGAATGGTTTAATTTACATCCTATGTTATGATTGGTCTAAGGGATAAGATTTGGGGTCTAACCTTTCCTTTCACTCT
AGTTAGTCATAGTCCTTGACTTATGCCTATATCTTTGTAAGAAATAGTATGTTTCATTTGTGATAGTATTGGTAGGGCTGAATATGGATG
GCATCTACTGTAAAACAAGTCTACCTTGTCAGATGTGCAAAAGCTTTCACTCTTGTTCTCAAATAAACTTTTGTGGGTTTTTTT

>3412_3412_6_AKIRIN1-MEAF6_AKIRIN1_chr1_39463983_ENST00000446189_MEAF6_chr1_37967597_ENST00000373075_length(amino acids)=208AA_BP=108
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRW
RHLEVVLNQSEACASESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDLDGSVQGVKPQKAASSTSSGSHHSSHKKRKN
KNRHSPSGMFDYDFEIDLKLNKKPRADY

--------------------------------------------------------------

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Fusion Gene PPI Analysis for AKIRIN1-MEAF6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AKIRIN1-MEAF6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AKIRIN1-MEAF6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource