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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C11orf80-FAM161B (FusionGDB2 ID:HG79703TG145483)

Fusion Gene Summary for C11orf80-FAM161B

check button Fusion gene summary
Fusion gene informationFusion gene name: C11orf80-FAM161B
Fusion gene ID: hg79703tg145483
HgeneTgene
Gene symbol

C11orf80

FAM161B

Gene ID

79703

145483

Gene namechromosome 11 open reading frame 80FAM161 centrosomal protein B
SynonymsHYDM4|TOP6BL|TOPOVIBLC14orf44|c14_5547
Cytomap('C11orf80')('FAM161B')

11q13.2

14q24.3

Type of geneprotein-codingprotein-coding
Descriptiontype 2 DNA topoisomerase 6 subunit B-liketype 2 DNA topoisomerase VI subunit B-likeprotein FAM161BFAM161B, centrosomal proteinfamily with sequence similarity 161 member B
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000527368, ENST00000527634, 
ENST00000532565, ENST00000346672, 
ENST00000360962, ENST00000525449, 
ENST00000540737, 
Fusion gene scores* DoF score13 X 8 X 7=7282 X 2 X 2=8
# samples 162
** MAII scorelog2(16/728*10)=-2.18586654531133
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: C11orf80 [Title/Abstract] AND FAM161B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC11orf80(66526567)-FAM161B(74409418), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across C11orf80 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across FAM161B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A24Q-01AC11orf80chr11

66526567

+FAM161Bchr14

74409418

-


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Fusion Gene ORF analysis for C11orf80-FAM161B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000527368ENST00000286544C11orf80chr11

66526567

+FAM161Bchr14

74409418

-
3UTR-3CDSENST00000527368ENST00000534936C11orf80chr11

66526567

+FAM161Bchr14

74409418

-
5UTR-3CDSENST00000527634ENST00000286544C11orf80chr11

66526567

+FAM161Bchr14

74409418

-
5UTR-3CDSENST00000527634ENST00000534936C11orf80chr11

66526567

+FAM161Bchr14

74409418

-
5UTR-3CDSENST00000532565ENST00000286544C11orf80chr11

66526567

+FAM161Bchr14

74409418

-
5UTR-3CDSENST00000532565ENST00000534936C11orf80chr11

66526567

+FAM161Bchr14

74409418

-
In-frameENST00000346672ENST00000286544C11orf80chr11

66526567

+FAM161Bchr14

74409418

-
In-frameENST00000346672ENST00000534936C11orf80chr11

66526567

+FAM161Bchr14

74409418

-
In-frameENST00000360962ENST00000286544C11orf80chr11

66526567

+FAM161Bchr14

74409418

-
In-frameENST00000360962ENST00000534936C11orf80chr11

66526567

+FAM161Bchr14

74409418

-
In-frameENST00000525449ENST00000286544C11orf80chr11

66526567

+FAM161Bchr14

74409418

-
In-frameENST00000525449ENST00000534936C11orf80chr11

66526567

+FAM161Bchr14

74409418

-
In-frameENST00000540737ENST00000286544C11orf80chr11

66526567

+FAM161Bchr14

74409418

-
In-frameENST00000540737ENST00000534936C11orf80chr11

66526567

+FAM161Bchr14

74409418

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000346672C11orf80chr1166526567+ENST00000286544FAM161Bchr1474409418-329553071548513
ENST00000346672C11orf80chr1166526567+ENST00000534936FAM161Bchr1474409418-180353071548513
ENST00000360962C11orf80chr1166526567+ENST00000286544FAM161Bchr1474409418-329553071548513
ENST00000360962C11orf80chr1166526567+ENST00000534936FAM161Bchr1474409418-180353071548513
ENST00000540737C11orf80chr1166526567+ENST00000286544FAM161Bchr1474409418-2952187811205374
ENST00000540737C11orf80chr1166526567+ENST00000534936FAM161Bchr1474409418-1460187811205374
ENST00000525449C11orf80chr1166526567+ENST00000286544FAM161Bchr1474409418-3096331421349435
ENST00000525449C11orf80chr1166526567+ENST00000534936FAM161Bchr1474409418-1604331421349435

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000346672ENST00000286544C11orf80chr1166526567+FAM161Bchr1474409418-0.011615370.9883846
ENST00000346672ENST00000534936C11orf80chr1166526567+FAM161Bchr1474409418-0.0349844430.96501553
ENST00000360962ENST00000286544C11orf80chr1166526567+FAM161Bchr1474409418-0.011615370.9883846
ENST00000360962ENST00000534936C11orf80chr1166526567+FAM161Bchr1474409418-0.0349844430.96501553
ENST00000540737ENST00000286544C11orf80chr1166526567+FAM161Bchr1474409418-0.0048407290.9951593
ENST00000540737ENST00000534936C11orf80chr1166526567+FAM161Bchr1474409418-0.0138112940.9861887
ENST00000525449ENST00000286544C11orf80chr1166526567+FAM161Bchr1474409418-0.0024869490.99751306
ENST00000525449ENST00000534936C11orf80chr1166526567+FAM161Bchr1474409418-0.0083010450.991699

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Fusion Genomic Features for C11orf80-FAM161B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for C11orf80-FAM161B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:66526567/chr14:74409418)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFAM161Bchr11:66526567chr14:74409418ENST0000028654429510_546371711.0Coiled coilOntology_term=ECO:0000255
TgeneFAM161Bchr11:66526567chr14:74409418ENST0000053493629510_546308648.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFAM161Bchr11:66526567chr14:74409418ENST0000028654429262_292371711.0Coiled coilOntology_term=ECO:0000255
TgeneFAM161Bchr11:66526567chr14:74409418ENST0000053493629262_292308648.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for C11orf80-FAM161B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>10768_10768_1_C11orf80-FAM161B_C11orf80_chr11_66526567_ENST00000346672_FAM161B_chr14_74409418_ENST00000286544_length(transcript)=3295nt_BP=530nt
GGAAGGGATGGGCTCGCGCTGCCGGGCGTGGGCGTGGACTCGGGCGTGGGCACTGGCGGAGTTCCAAGCCCGGGCTGAGGAGGGGGCGGC
GGCGGCGGCGGCGGCGGCGGGCGGGTACCCTTCGACTGGGCGTTGCCGCTGTTCCCTGCGCGGCATGGAGGGGACGGCCGTGGCCGTGTT
CGAGATTTTGAGATTTTTAATAATTCACTGGAAGTGTGACATAGATGTATCAAAGGGAGCATTGCTAGAAGGGCAGCTAGTGATTTCCAT
AGAAGGATTAAATTCTAAGCACCAGGCAAATGCTCTTCATTGTGTAACAACTAGATGGAGTCTCACTCTGTTACCCAGGCCGGAGTGCAG
TGGCGCAGTCTCGGCTCACTGCAACCTCCACCTCCCAGGTTCAAGTGATTCTCATGCCTCAGTCCCCCGAGTAGCTGGGATTACAGATGC
CCACCACCATGCCTGGCTAATTATGGTTGCTTCTGCAGGAAGCCTTTTTGGTGGCATGGTCCTCAAGAAGTTCCTAAAAGAAGCTGAGCT
CTTCAGGAAAATTCGCATCCAAATGAGAGCCCTGGACATGCTCCAGATGGCCTCTTCCCCTATCGCCTCCTCTAGTAACCGGGCTAACCC
ACAGCCCCGCACAGCCACCCGAACCCAGCAGGAAAAGCTTGGGTTTCTGCACACTAACTTCAGATTCCAGCCTCGGGTGAATCCTGTGGT
CCCTGACTATGAGGGCCTTTACAAGGCCTTCCAGAGAAGAGCAGCCAAAAGAAGAGAAACCCAAGAGGCCACTCGCAACAAGCCCTTCTT
GCTGAGGACCGCCAACCTGCGCCACCCTCAGCGGCCCTGTGATGCTGCCACCACCGGAAGGAGGCAGGATTCCCCACAGCCACCAGCTAC
ACCCCTGCCAAGGAGTCGTTCTCTGAGCGGCCTTGCTTCCCTCTCTGCCAACACTCTCCCTGTGCACATCACAGATGCCACCAGGAAGAG
GGAATCTGCAGTCAGAAGTGCACTTGAAAAAAAGAACAAAGCAGATGAGAGTATTCAGTGGCTGGAGATACACAAAAAGAAGTCTCAAGC
AATGTCCAAATCTGTGACCTTGCGTGCAAAAGCCATGGATCCCCATAAAAGCCTGGAGGAAGTGTTCAAAGCAAAGCTGAAAGAGAACCG
GAACAATGACCGTAAAAGAGCGAAAGAATATAAGAAAGAACTGGAGGAAATGAAGCAGCGAATACAAACAAGGCCCTATCTCTTTGAACA
AGTTGCCAAGGATCTAGCCAAGAAAGAAGCAGAACAGTGGTATCTAGACACCCTGAAGCAGGCTGGGCTGGAGGAAGACTTTGTGAGAAA
CAAGGGTCAAGGCACCCGGGCTGTTCAAGAGAAAGAGACCAAAATCAAGGATTTTCCCAGGTTCCAAGAAACTACAAAACTCAGCATCAG
AGATCCAGAGCAGGGTTTAGAAGGATCTCTAGAACAGCCTGCAAGCCCCAGGAAAGTACTGGAGGAGCTGTCTCATCAGTCACCAGAAAA
TCTCGTATCACTTGCTTAATCACTACACTTAAAATTACTGCTTTTGAAAAATATTAAGCAGCTAACTTGGGTTTGAGTCAAGGCAGGGAA
AACTTGGGTTTTGAGTCATGGCTACTGTTAGAGGATGGACAAATGAAGAGTAGCAGATTAACAGGCCAGGCGCAGTGGCTCACGCCTGTA
ATCCCAACACTTTGGGAGGCTGAGGCAGGCAGATCATCTGAGGTCAGGAGTTTGAGACCAGTCCAGCCAACACGGCAAAACTCCACCTCT
ACTAAAAATACAAAAATTAGCTGGGCGTGATGACACGTGCCTGTAATCCTAGCTACTTGGGAAGCTGAGGCAGGAGAATCACTTGAACCC
AAGAGGCAGAGGTTGTAATGAGCTGAGATCACTCCACAGCACTCCAGCCTGGGCAGCAGAGCAAAACTCTGTCTGAGAAAAAAAAAGAGC
AGCAGATAACAGAGAATAGTTCAAGGAAATCAAAGTGGGGAGGCTCAGGTGGAGGGATGGTAGCCTAAAGTTAAGGGTTCCTGCTTTGTG
CCTCACACTTAGAGAATTAGGTACAGAAAAGAGAGCACAGGCCCAAATGCCTATAAGGGGCTAGTGCAGAAACATAAATGCGTCCATGGA
GTGGGTGTAGACAGTAGGAGATAGTAGACACTGGAAAGTATCAAATCCTGCTGGAATATAGGCTCAGAGTTACTACATCAACTACATTTT
CATCAAGCCAGAAATTTGTATGCTATCAACTAATTTAAAAATTACTTAGAAATATTGTATGGGCAAAATAAAATACATCTGCATATCAGA
TCTAGCCCATGGGGGATGAAAAACTTACAACTTCTAGTACAGGATTTCTTATCCTCAGTGCTATTAATATTTTGGGCCACCTAATTCTTT
GTTGAGGGTTGGGGAAGGGAACTGTCCTGTACATTGTAGAATGTTTAGTAGCATCCCTGGCCACTACCTGCTAGATGCCAGTAGTACCCC
TCTCCCCAGCTGTGACAACCAAAAATGTCTCCAGATATTGCATATCCCCAGGGGGCAAAAATGTGCCTGGCTGAGAACCACTGCTCTAAT
ATAAATGGCTGCATGAAGCAAAAACTGGCATTCTAAGAATACAAGTAATTGCCATGAACACAGTCTATGTACTATGTGATTATGCATGTC
ATTAACAAATTAAGAATTTAAAACAATTCTCTCCCGTTATCTGTTTAGAATGTGCCTGTGTGTTTATGTGAGCATGAGGTTCATTTTAAG
TAAACTTAAAATTTCCCAGACAACCAAGATTTTCTACTAGTAGGTGAACTTTGGAATAATTTTCTTCTCACCAATAATAATTGGATATTC
TGGCTCGGTGCAGTGGTTCATGCTTGTAATCCCAGCACTTTGAGGGGCCAAGGCAGGAGGATCGCTTGAAGCCAGGCGTTCAAGACCAGC
CTGGGCAACACAGACCTCATTTCTACCAAAAAAACCACAAAAAGTTAGCTGGACTGGTGGTACATGCCTATAGTCCTAGCTATTCAGGAG
GCTGAGGTGGGAGGATGCCTTGAGCGTAGGAGTTCAAGGTTACATTGAGCTATGATTACACTACTGCACTCCAGCCTGGGTGACAGAGCA
AGACCCCATCTCAAATCATAATGATGATGAGTGGATATTTTCTCAGTAGCTGTGGAGACAGGATGACTGATAGCAAGAGTGCCTGCTCTA
ACTAAAGCACCTTTCTCAAGCTTTTTTAAAAAAACTATCTTTGTGGAAAAATTCA

>10768_10768_1_C11orf80-FAM161B_C11orf80_chr11_66526567_ENST00000346672_FAM161B_chr14_74409418_ENST00000286544_length(amino acids)=513AA_BP=105
MGSRCRAWAWTRAWALAEFQARAEEGAAAAAAAAGGYPSTGRCRCSLRGMEGTAVAVFEILRFLIIHWKCDIDVSKGALLEGQLVISIEG
LNSKHQANALHCVTTRWSLTLLPRPECSGAVSAHCNLHLPGSSDSHASVPRVAGITDAHHHAWLIMVASAGSLFGGMVLKKFLKEAELFR
KIRIQMRALDMLQMASSPIASSSNRANPQPRTATRTQQEKLGFLHTNFRFQPRVNPVVPDYEGLYKAFQRRAAKRRETQEATRNKPFLLR
TANLRHPQRPCDAATTGRRQDSPQPPATPLPRSRSLSGLASLSANTLPVHITDATRKRESAVRSALEKKNKADESIQWLEIHKKKSQAMS
KSVTLRAKAMDPHKSLEEVFKAKLKENRNNDRKRAKEYKKELEEMKQRIQTRPYLFEQVAKDLAKKEAEQWYLDTLKQAGLEEDFVRNKG
QGTRAVQEKETKIKDFPRFQETTKLSIRDPEQGLEGSLEQPASPRKVLEELSHQSPENLVSLA

--------------------------------------------------------------
>10768_10768_2_C11orf80-FAM161B_C11orf80_chr11_66526567_ENST00000346672_FAM161B_chr14_74409418_ENST00000534936_length(transcript)=1803nt_BP=530nt
GGAAGGGATGGGCTCGCGCTGCCGGGCGTGGGCGTGGACTCGGGCGTGGGCACTGGCGGAGTTCCAAGCCCGGGCTGAGGAGGGGGCGGC
GGCGGCGGCGGCGGCGGCGGGCGGGTACCCTTCGACTGGGCGTTGCCGCTGTTCCCTGCGCGGCATGGAGGGGACGGCCGTGGCCGTGTT
CGAGATTTTGAGATTTTTAATAATTCACTGGAAGTGTGACATAGATGTATCAAAGGGAGCATTGCTAGAAGGGCAGCTAGTGATTTCCAT
AGAAGGATTAAATTCTAAGCACCAGGCAAATGCTCTTCATTGTGTAACAACTAGATGGAGTCTCACTCTGTTACCCAGGCCGGAGTGCAG
TGGCGCAGTCTCGGCTCACTGCAACCTCCACCTCCCAGGTTCAAGTGATTCTCATGCCTCAGTCCCCCGAGTAGCTGGGATTACAGATGC
CCACCACCATGCCTGGCTAATTATGGTTGCTTCTGCAGGAAGCCTTTTTGGTGGCATGGTCCTCAAGAAGTTCCTAAAAGAAGCTGAGCT
CTTCAGGAAAATTCGCATCCAAATGAGAGCCCTGGACATGCTCCAGATGGCCTCTTCCCCTATCGCCTCCTCTAGTAACCGGGCTAACCC
ACAGCCCCGCACAGCCACCCGAACCCAGCAGGAAAAGCTTGGGTTTCTGCACACTAACTTCAGATTCCAGCCTCGGGTGAATCCTGTGGT
CCCTGACTATGAGGGCCTTTACAAGGCCTTCCAGAGAAGAGCAGCCAAAAGAAGAGAAACCCAAGAGGCCACTCGCAACAAGCCCTTCTT
GCTGAGGACCGCCAACCTGCGCCACCCTCAGCGGCCCTGTGATGCTGCCACCACCGGAAGGAGGCAGGATTCCCCACAGCCACCAGCTAC
ACCCCTGCCAAGGAGTCGTTCTCTGAGCGGCCTTGCTTCCCTCTCTGCCAACACTCTCCCTGTGCACATCACAGATGCCACCAGGAAGAG
GGAATCTGCAGTCAGAAGTGCACTTGAAAAAAAGAACAAAGCAGATGAGAGTATTCAGTGGCTGGAGATACACAAAAAGAAGTCTCAAGC
AATGTCCAAATCTGTGACCTTGCGTGCAAAAGCCATGGATCCCCATAAAAGCCTGGAGGAAGTGTTCAAAGCAAAGCTGAAAGAGAACCG
GAACAATGACCGTAAAAGAGCGAAAGAATATAAGAAAGAACTGGAGGAAATGAAGCAGCGAATACAAACAAGGCCCTATCTCTTTGAACA
AGTTGCCAAGGATCTAGCCAAGAAAGAAGCAGAACAGTGGTATCTAGACACCCTGAAGCAGGCTGGGCTGGAGGAAGACTTTGTGAGAAA
CAAGGGTCAAGGCACCCGGGCTGTTCAAGAGAAAGAGACCAAAATCAAGGATTTTCCCAGGTTCCAAGAAACTACAAAACTCAGCATCAG
AGATCCAGAGCAGGGTTTAGAAGGATCTCTAGAACAGCCTGCAAGCCCCAGGAAAGTACTGGAGGAGCTGTCTCATCAGTCACCAGAAAA
TCTCGTATCACTTGCTTAATCACTACACTTAAAATTACTGCTTTTGAAAAATATTAAGCAGCTAACTTGGGTTTGAGTCAAGGCAGGGAA
AACTTGGGTTTTGAGTCATGGCTACTGTTAGAGGATGGACAAATGAAGAGTAGCAGATTAACAGGCCAGGCGCAGTGGCTCACGCCTGTA
ATCCCAACACTTTGGGAGGCTGAGGCAGGCAGATCATCTGAGGTCAGGAGTTTGAGACCAGTCCAGCCAACACGGCAAAACTCCACCTCT
ACT

>10768_10768_2_C11orf80-FAM161B_C11orf80_chr11_66526567_ENST00000346672_FAM161B_chr14_74409418_ENST00000534936_length(amino acids)=513AA_BP=105
MGSRCRAWAWTRAWALAEFQARAEEGAAAAAAAAGGYPSTGRCRCSLRGMEGTAVAVFEILRFLIIHWKCDIDVSKGALLEGQLVISIEG
LNSKHQANALHCVTTRWSLTLLPRPECSGAVSAHCNLHLPGSSDSHASVPRVAGITDAHHHAWLIMVASAGSLFGGMVLKKFLKEAELFR
KIRIQMRALDMLQMASSPIASSSNRANPQPRTATRTQQEKLGFLHTNFRFQPRVNPVVPDYEGLYKAFQRRAAKRRETQEATRNKPFLLR
TANLRHPQRPCDAATTGRRQDSPQPPATPLPRSRSLSGLASLSANTLPVHITDATRKRESAVRSALEKKNKADESIQWLEIHKKKSQAMS
KSVTLRAKAMDPHKSLEEVFKAKLKENRNNDRKRAKEYKKELEEMKQRIQTRPYLFEQVAKDLAKKEAEQWYLDTLKQAGLEEDFVRNKG
QGTRAVQEKETKIKDFPRFQETTKLSIRDPEQGLEGSLEQPASPRKVLEELSHQSPENLVSLA

--------------------------------------------------------------
>10768_10768_3_C11orf80-FAM161B_C11orf80_chr11_66526567_ENST00000360962_FAM161B_chr14_74409418_ENST00000286544_length(transcript)=3295nt_BP=530nt
GGAAGGGATGGGCTCGCGCTGCCGGGCGTGGGCGTGGACTCGGGCGTGGGCACTGGCGGAGTTCCAAGCCCGGGCTGAGGAGGGGGCGGC
GGCGGCGGCGGCGGCGGCGGGCGGGTACCCTTCGACTGGGCGTTGCCGCTGTTCCCTGCGCGGCATGGAGGGGACGGCCGTGGCCGTGTT
CGAGATTTTGAGATTTTTAATAATTCACTGGAAGTGTGACATAGATGTATCAAAGGGAGCATTGCTAGAAGGGCAGCTAGTGATTTCCAT
AGAAGGATTAAATTCTAAGCACCAGGCAAATGCTCTTCATTGTGTAACAACTAGATGGAGTCTCACTCTGTTACCCAGGCCGGAGTGCAG
TGGCGCAGTCTCGGCTCACTGCAACCTCCACCTCCCAGGTTCAAGTGATTCTCATGCCTCAGTCCCCCGAGTAGCTGGGATTACAGATGC
CCACCACCATGCCTGGCTAATTATGGTTGCTTCTGCAGGAAGCCTTTTTGGTGGCATGGTCCTCAAGAAGTTCCTAAAAGAAGCTGAGCT
CTTCAGGAAAATTCGCATCCAAATGAGAGCCCTGGACATGCTCCAGATGGCCTCTTCCCCTATCGCCTCCTCTAGTAACCGGGCTAACCC
ACAGCCCCGCACAGCCACCCGAACCCAGCAGGAAAAGCTTGGGTTTCTGCACACTAACTTCAGATTCCAGCCTCGGGTGAATCCTGTGGT
CCCTGACTATGAGGGCCTTTACAAGGCCTTCCAGAGAAGAGCAGCCAAAAGAAGAGAAACCCAAGAGGCCACTCGCAACAAGCCCTTCTT
GCTGAGGACCGCCAACCTGCGCCACCCTCAGCGGCCCTGTGATGCTGCCACCACCGGAAGGAGGCAGGATTCCCCACAGCCACCAGCTAC
ACCCCTGCCAAGGAGTCGTTCTCTGAGCGGCCTTGCTTCCCTCTCTGCCAACACTCTCCCTGTGCACATCACAGATGCCACCAGGAAGAG
GGAATCTGCAGTCAGAAGTGCACTTGAAAAAAAGAACAAAGCAGATGAGAGTATTCAGTGGCTGGAGATACACAAAAAGAAGTCTCAAGC
AATGTCCAAATCTGTGACCTTGCGTGCAAAAGCCATGGATCCCCATAAAAGCCTGGAGGAAGTGTTCAAAGCAAAGCTGAAAGAGAACCG
GAACAATGACCGTAAAAGAGCGAAAGAATATAAGAAAGAACTGGAGGAAATGAAGCAGCGAATACAAACAAGGCCCTATCTCTTTGAACA
AGTTGCCAAGGATCTAGCCAAGAAAGAAGCAGAACAGTGGTATCTAGACACCCTGAAGCAGGCTGGGCTGGAGGAAGACTTTGTGAGAAA
CAAGGGTCAAGGCACCCGGGCTGTTCAAGAGAAAGAGACCAAAATCAAGGATTTTCCCAGGTTCCAAGAAACTACAAAACTCAGCATCAG
AGATCCAGAGCAGGGTTTAGAAGGATCTCTAGAACAGCCTGCAAGCCCCAGGAAAGTACTGGAGGAGCTGTCTCATCAGTCACCAGAAAA
TCTCGTATCACTTGCTTAATCACTACACTTAAAATTACTGCTTTTGAAAAATATTAAGCAGCTAACTTGGGTTTGAGTCAAGGCAGGGAA
AACTTGGGTTTTGAGTCATGGCTACTGTTAGAGGATGGACAAATGAAGAGTAGCAGATTAACAGGCCAGGCGCAGTGGCTCACGCCTGTA
ATCCCAACACTTTGGGAGGCTGAGGCAGGCAGATCATCTGAGGTCAGGAGTTTGAGACCAGTCCAGCCAACACGGCAAAACTCCACCTCT
ACTAAAAATACAAAAATTAGCTGGGCGTGATGACACGTGCCTGTAATCCTAGCTACTTGGGAAGCTGAGGCAGGAGAATCACTTGAACCC
AAGAGGCAGAGGTTGTAATGAGCTGAGATCACTCCACAGCACTCCAGCCTGGGCAGCAGAGCAAAACTCTGTCTGAGAAAAAAAAAGAGC
AGCAGATAACAGAGAATAGTTCAAGGAAATCAAAGTGGGGAGGCTCAGGTGGAGGGATGGTAGCCTAAAGTTAAGGGTTCCTGCTTTGTG
CCTCACACTTAGAGAATTAGGTACAGAAAAGAGAGCACAGGCCCAAATGCCTATAAGGGGCTAGTGCAGAAACATAAATGCGTCCATGGA
GTGGGTGTAGACAGTAGGAGATAGTAGACACTGGAAAGTATCAAATCCTGCTGGAATATAGGCTCAGAGTTACTACATCAACTACATTTT
CATCAAGCCAGAAATTTGTATGCTATCAACTAATTTAAAAATTACTTAGAAATATTGTATGGGCAAAATAAAATACATCTGCATATCAGA
TCTAGCCCATGGGGGATGAAAAACTTACAACTTCTAGTACAGGATTTCTTATCCTCAGTGCTATTAATATTTTGGGCCACCTAATTCTTT
GTTGAGGGTTGGGGAAGGGAACTGTCCTGTACATTGTAGAATGTTTAGTAGCATCCCTGGCCACTACCTGCTAGATGCCAGTAGTACCCC
TCTCCCCAGCTGTGACAACCAAAAATGTCTCCAGATATTGCATATCCCCAGGGGGCAAAAATGTGCCTGGCTGAGAACCACTGCTCTAAT
ATAAATGGCTGCATGAAGCAAAAACTGGCATTCTAAGAATACAAGTAATTGCCATGAACACAGTCTATGTACTATGTGATTATGCATGTC
ATTAACAAATTAAGAATTTAAAACAATTCTCTCCCGTTATCTGTTTAGAATGTGCCTGTGTGTTTATGTGAGCATGAGGTTCATTTTAAG
TAAACTTAAAATTTCCCAGACAACCAAGATTTTCTACTAGTAGGTGAACTTTGGAATAATTTTCTTCTCACCAATAATAATTGGATATTC
TGGCTCGGTGCAGTGGTTCATGCTTGTAATCCCAGCACTTTGAGGGGCCAAGGCAGGAGGATCGCTTGAAGCCAGGCGTTCAAGACCAGC
CTGGGCAACACAGACCTCATTTCTACCAAAAAAACCACAAAAAGTTAGCTGGACTGGTGGTACATGCCTATAGTCCTAGCTATTCAGGAG
GCTGAGGTGGGAGGATGCCTTGAGCGTAGGAGTTCAAGGTTACATTGAGCTATGATTACACTACTGCACTCCAGCCTGGGTGACAGAGCA
AGACCCCATCTCAAATCATAATGATGATGAGTGGATATTTTCTCAGTAGCTGTGGAGACAGGATGACTGATAGCAAGAGTGCCTGCTCTA
ACTAAAGCACCTTTCTCAAGCTTTTTTAAAAAAACTATCTTTGTGGAAAAATTCA

>10768_10768_3_C11orf80-FAM161B_C11orf80_chr11_66526567_ENST00000360962_FAM161B_chr14_74409418_ENST00000286544_length(amino acids)=513AA_BP=105
MGSRCRAWAWTRAWALAEFQARAEEGAAAAAAAAGGYPSTGRCRCSLRGMEGTAVAVFEILRFLIIHWKCDIDVSKGALLEGQLVISIEG
LNSKHQANALHCVTTRWSLTLLPRPECSGAVSAHCNLHLPGSSDSHASVPRVAGITDAHHHAWLIMVASAGSLFGGMVLKKFLKEAELFR
KIRIQMRALDMLQMASSPIASSSNRANPQPRTATRTQQEKLGFLHTNFRFQPRVNPVVPDYEGLYKAFQRRAAKRRETQEATRNKPFLLR
TANLRHPQRPCDAATTGRRQDSPQPPATPLPRSRSLSGLASLSANTLPVHITDATRKRESAVRSALEKKNKADESIQWLEIHKKKSQAMS
KSVTLRAKAMDPHKSLEEVFKAKLKENRNNDRKRAKEYKKELEEMKQRIQTRPYLFEQVAKDLAKKEAEQWYLDTLKQAGLEEDFVRNKG
QGTRAVQEKETKIKDFPRFQETTKLSIRDPEQGLEGSLEQPASPRKVLEELSHQSPENLVSLA

--------------------------------------------------------------
>10768_10768_4_C11orf80-FAM161B_C11orf80_chr11_66526567_ENST00000360962_FAM161B_chr14_74409418_ENST00000534936_length(transcript)=1803nt_BP=530nt
GGAAGGGATGGGCTCGCGCTGCCGGGCGTGGGCGTGGACTCGGGCGTGGGCACTGGCGGAGTTCCAAGCCCGGGCTGAGGAGGGGGCGGC
GGCGGCGGCGGCGGCGGCGGGCGGGTACCCTTCGACTGGGCGTTGCCGCTGTTCCCTGCGCGGCATGGAGGGGACGGCCGTGGCCGTGTT
CGAGATTTTGAGATTTTTAATAATTCACTGGAAGTGTGACATAGATGTATCAAAGGGAGCATTGCTAGAAGGGCAGCTAGTGATTTCCAT
AGAAGGATTAAATTCTAAGCACCAGGCAAATGCTCTTCATTGTGTAACAACTAGATGGAGTCTCACTCTGTTACCCAGGCCGGAGTGCAG
TGGCGCAGTCTCGGCTCACTGCAACCTCCACCTCCCAGGTTCAAGTGATTCTCATGCCTCAGTCCCCCGAGTAGCTGGGATTACAGATGC
CCACCACCATGCCTGGCTAATTATGGTTGCTTCTGCAGGAAGCCTTTTTGGTGGCATGGTCCTCAAGAAGTTCCTAAAAGAAGCTGAGCT
CTTCAGGAAAATTCGCATCCAAATGAGAGCCCTGGACATGCTCCAGATGGCCTCTTCCCCTATCGCCTCCTCTAGTAACCGGGCTAACCC
ACAGCCCCGCACAGCCACCCGAACCCAGCAGGAAAAGCTTGGGTTTCTGCACACTAACTTCAGATTCCAGCCTCGGGTGAATCCTGTGGT
CCCTGACTATGAGGGCCTTTACAAGGCCTTCCAGAGAAGAGCAGCCAAAAGAAGAGAAACCCAAGAGGCCACTCGCAACAAGCCCTTCTT
GCTGAGGACCGCCAACCTGCGCCACCCTCAGCGGCCCTGTGATGCTGCCACCACCGGAAGGAGGCAGGATTCCCCACAGCCACCAGCTAC
ACCCCTGCCAAGGAGTCGTTCTCTGAGCGGCCTTGCTTCCCTCTCTGCCAACACTCTCCCTGTGCACATCACAGATGCCACCAGGAAGAG
GGAATCTGCAGTCAGAAGTGCACTTGAAAAAAAGAACAAAGCAGATGAGAGTATTCAGTGGCTGGAGATACACAAAAAGAAGTCTCAAGC
AATGTCCAAATCTGTGACCTTGCGTGCAAAAGCCATGGATCCCCATAAAAGCCTGGAGGAAGTGTTCAAAGCAAAGCTGAAAGAGAACCG
GAACAATGACCGTAAAAGAGCGAAAGAATATAAGAAAGAACTGGAGGAAATGAAGCAGCGAATACAAACAAGGCCCTATCTCTTTGAACA
AGTTGCCAAGGATCTAGCCAAGAAAGAAGCAGAACAGTGGTATCTAGACACCCTGAAGCAGGCTGGGCTGGAGGAAGACTTTGTGAGAAA
CAAGGGTCAAGGCACCCGGGCTGTTCAAGAGAAAGAGACCAAAATCAAGGATTTTCCCAGGTTCCAAGAAACTACAAAACTCAGCATCAG
AGATCCAGAGCAGGGTTTAGAAGGATCTCTAGAACAGCCTGCAAGCCCCAGGAAAGTACTGGAGGAGCTGTCTCATCAGTCACCAGAAAA
TCTCGTATCACTTGCTTAATCACTACACTTAAAATTACTGCTTTTGAAAAATATTAAGCAGCTAACTTGGGTTTGAGTCAAGGCAGGGAA
AACTTGGGTTTTGAGTCATGGCTACTGTTAGAGGATGGACAAATGAAGAGTAGCAGATTAACAGGCCAGGCGCAGTGGCTCACGCCTGTA
ATCCCAACACTTTGGGAGGCTGAGGCAGGCAGATCATCTGAGGTCAGGAGTTTGAGACCAGTCCAGCCAACACGGCAAAACTCCACCTCT
ACT

>10768_10768_4_C11orf80-FAM161B_C11orf80_chr11_66526567_ENST00000360962_FAM161B_chr14_74409418_ENST00000534936_length(amino acids)=513AA_BP=105
MGSRCRAWAWTRAWALAEFQARAEEGAAAAAAAAGGYPSTGRCRCSLRGMEGTAVAVFEILRFLIIHWKCDIDVSKGALLEGQLVISIEG
LNSKHQANALHCVTTRWSLTLLPRPECSGAVSAHCNLHLPGSSDSHASVPRVAGITDAHHHAWLIMVASAGSLFGGMVLKKFLKEAELFR
KIRIQMRALDMLQMASSPIASSSNRANPQPRTATRTQQEKLGFLHTNFRFQPRVNPVVPDYEGLYKAFQRRAAKRRETQEATRNKPFLLR
TANLRHPQRPCDAATTGRRQDSPQPPATPLPRSRSLSGLASLSANTLPVHITDATRKRESAVRSALEKKNKADESIQWLEIHKKKSQAMS
KSVTLRAKAMDPHKSLEEVFKAKLKENRNNDRKRAKEYKKELEEMKQRIQTRPYLFEQVAKDLAKKEAEQWYLDTLKQAGLEEDFVRNKG
QGTRAVQEKETKIKDFPRFQETTKLSIRDPEQGLEGSLEQPASPRKVLEELSHQSPENLVSLA

--------------------------------------------------------------
>10768_10768_5_C11orf80-FAM161B_C11orf80_chr11_66526567_ENST00000525449_FAM161B_chr14_74409418_ENST00000286544_length(transcript)=3096nt_BP=331nt
ATAATTCACTGGAAGTGTGACATAGATGTATCAAAGGGAGCATTGCTAGAAGGGCAGCTAGTGATTTCCATAGAAGGATTAAATTCTAAG
CACCAGGCAAATGCTCTTCATTGTGTAACAACTAGATGGAGTCTCACTCTGTTACCCAGGCCGGAGTGCAGTGGCGCAGTCTCGGCTCAC
TGCAACCTCCACCTCCCAGGTTCAAGTGATTCTCATGCCTCAGTCCCCCGAGTAGCTGGGATTACAGATGCCCACCACCATGCCTGGCTA
ATTATGGTTGCTTCTGCAGGAAGCCTTTTTGGTGGCATGGTCCTCAAGAAGTTCCTAAAAGAAGCTGAGCTCTTCAGGAAAATTCGCATC
CAAATGAGAGCCCTGGACATGCTCCAGATGGCCTCTTCCCCTATCGCCTCCTCTAGTAACCGGGCTAACCCACAGCCCCGCACAGCCACC
CGAACCCAGCAGGAAAAGCTTGGGTTTCTGCACACTAACTTCAGATTCCAGCCTCGGGTGAATCCTGTGGTCCCTGACTATGAGGGCCTT
TACAAGGCCTTCCAGAGAAGAGCAGCCAAAAGAAGAGAAACCCAAGAGGCCACTCGCAACAAGCCCTTCTTGCTGAGGACCGCCAACCTG
CGCCACCCTCAGCGGCCCTGTGATGCTGCCACCACCGGAAGGAGGCAGGATTCCCCACAGCCACCAGCTACACCCCTGCCAAGGAGTCGT
TCTCTGAGCGGCCTTGCTTCCCTCTCTGCCAACACTCTCCCTGTGCACATCACAGATGCCACCAGGAAGAGGGAATCTGCAGTCAGAAGT
GCACTTGAAAAAAAGAACAAAGCAGATGAGAGTATTCAGTGGCTGGAGATACACAAAAAGAAGTCTCAAGCAATGTCCAAATCTGTGACC
TTGCGTGCAAAAGCCATGGATCCCCATAAAAGCCTGGAGGAAGTGTTCAAAGCAAAGCTGAAAGAGAACCGGAACAATGACCGTAAAAGA
GCGAAAGAATATAAGAAAGAACTGGAGGAAATGAAGCAGCGAATACAAACAAGGCCCTATCTCTTTGAACAAGTTGCCAAGGATCTAGCC
AAGAAAGAAGCAGAACAGTGGTATCTAGACACCCTGAAGCAGGCTGGGCTGGAGGAAGACTTTGTGAGAAACAAGGGTCAAGGCACCCGG
GCTGTTCAAGAGAAAGAGACCAAAATCAAGGATTTTCCCAGGTTCCAAGAAACTACAAAACTCAGCATCAGAGATCCAGAGCAGGGTTTA
GAAGGATCTCTAGAACAGCCTGCAAGCCCCAGGAAAGTACTGGAGGAGCTGTCTCATCAGTCACCAGAAAATCTCGTATCACTTGCTTAA
TCACTACACTTAAAATTACTGCTTTTGAAAAATATTAAGCAGCTAACTTGGGTTTGAGTCAAGGCAGGGAAAACTTGGGTTTTGAGTCAT
GGCTACTGTTAGAGGATGGACAAATGAAGAGTAGCAGATTAACAGGCCAGGCGCAGTGGCTCACGCCTGTAATCCCAACACTTTGGGAGG
CTGAGGCAGGCAGATCATCTGAGGTCAGGAGTTTGAGACCAGTCCAGCCAACACGGCAAAACTCCACCTCTACTAAAAATACAAAAATTA
GCTGGGCGTGATGACACGTGCCTGTAATCCTAGCTACTTGGGAAGCTGAGGCAGGAGAATCACTTGAACCCAAGAGGCAGAGGTTGTAAT
GAGCTGAGATCACTCCACAGCACTCCAGCCTGGGCAGCAGAGCAAAACTCTGTCTGAGAAAAAAAAAGAGCAGCAGATAACAGAGAATAG
TTCAAGGAAATCAAAGTGGGGAGGCTCAGGTGGAGGGATGGTAGCCTAAAGTTAAGGGTTCCTGCTTTGTGCCTCACACTTAGAGAATTA
GGTACAGAAAAGAGAGCACAGGCCCAAATGCCTATAAGGGGCTAGTGCAGAAACATAAATGCGTCCATGGAGTGGGTGTAGACAGTAGGA
GATAGTAGACACTGGAAAGTATCAAATCCTGCTGGAATATAGGCTCAGAGTTACTACATCAACTACATTTTCATCAAGCCAGAAATTTGT
ATGCTATCAACTAATTTAAAAATTACTTAGAAATATTGTATGGGCAAAATAAAATACATCTGCATATCAGATCTAGCCCATGGGGGATGA
AAAACTTACAACTTCTAGTACAGGATTTCTTATCCTCAGTGCTATTAATATTTTGGGCCACCTAATTCTTTGTTGAGGGTTGGGGAAGGG
AACTGTCCTGTACATTGTAGAATGTTTAGTAGCATCCCTGGCCACTACCTGCTAGATGCCAGTAGTACCCCTCTCCCCAGCTGTGACAAC
CAAAAATGTCTCCAGATATTGCATATCCCCAGGGGGCAAAAATGTGCCTGGCTGAGAACCACTGCTCTAATATAAATGGCTGCATGAAGC
AAAAACTGGCATTCTAAGAATACAAGTAATTGCCATGAACACAGTCTATGTACTATGTGATTATGCATGTCATTAACAAATTAAGAATTT
AAAACAATTCTCTCCCGTTATCTGTTTAGAATGTGCCTGTGTGTTTATGTGAGCATGAGGTTCATTTTAAGTAAACTTAAAATTTCCCAG
ACAACCAAGATTTTCTACTAGTAGGTGAACTTTGGAATAATTTTCTTCTCACCAATAATAATTGGATATTCTGGCTCGGTGCAGTGGTTC
ATGCTTGTAATCCCAGCACTTTGAGGGGCCAAGGCAGGAGGATCGCTTGAAGCCAGGCGTTCAAGACCAGCCTGGGCAACACAGACCTCA
TTTCTACCAAAAAAACCACAAAAAGTTAGCTGGACTGGTGGTACATGCCTATAGTCCTAGCTATTCAGGAGGCTGAGGTGGGAGGATGCC
TTGAGCGTAGGAGTTCAAGGTTACATTGAGCTATGATTACACTACTGCACTCCAGCCTGGGTGACAGAGCAAGACCCCATCTCAAATCAT
AATGATGATGAGTGGATATTTTCTCAGTAGCTGTGGAGACAGGATGACTGATAGCAAGAGTGCCTGCTCTAACTAAAGCACCTTTCTCAA
GCTTTTTTAAAAAAACTATCTTTGTGGAAAAATTCA

>10768_10768_5_C11orf80-FAM161B_C11orf80_chr11_66526567_ENST00000525449_FAM161B_chr14_74409418_ENST00000286544_length(amino acids)=435AA_BP=27
MLEGQLVISIEGLNSKHQANALHCVTTRWSLTLLPRPECSGAVSAHCNLHLPGSSDSHASVPRVAGITDAHHHAWLIMVASAGSLFGGMV
LKKFLKEAELFRKIRIQMRALDMLQMASSPIASSSNRANPQPRTATRTQQEKLGFLHTNFRFQPRVNPVVPDYEGLYKAFQRRAAKRRET
QEATRNKPFLLRTANLRHPQRPCDAATTGRRQDSPQPPATPLPRSRSLSGLASLSANTLPVHITDATRKRESAVRSALEKKNKADESIQW
LEIHKKKSQAMSKSVTLRAKAMDPHKSLEEVFKAKLKENRNNDRKRAKEYKKELEEMKQRIQTRPYLFEQVAKDLAKKEAEQWYLDTLKQ
AGLEEDFVRNKGQGTRAVQEKETKIKDFPRFQETTKLSIRDPEQGLEGSLEQPASPRKVLEELSHQSPENLVSLA

--------------------------------------------------------------
>10768_10768_6_C11orf80-FAM161B_C11orf80_chr11_66526567_ENST00000525449_FAM161B_chr14_74409418_ENST00000534936_length(transcript)=1604nt_BP=331nt
ATAATTCACTGGAAGTGTGACATAGATGTATCAAAGGGAGCATTGCTAGAAGGGCAGCTAGTGATTTCCATAGAAGGATTAAATTCTAAG
CACCAGGCAAATGCTCTTCATTGTGTAACAACTAGATGGAGTCTCACTCTGTTACCCAGGCCGGAGTGCAGTGGCGCAGTCTCGGCTCAC
TGCAACCTCCACCTCCCAGGTTCAAGTGATTCTCATGCCTCAGTCCCCCGAGTAGCTGGGATTACAGATGCCCACCACCATGCCTGGCTA
ATTATGGTTGCTTCTGCAGGAAGCCTTTTTGGTGGCATGGTCCTCAAGAAGTTCCTAAAAGAAGCTGAGCTCTTCAGGAAAATTCGCATC
CAAATGAGAGCCCTGGACATGCTCCAGATGGCCTCTTCCCCTATCGCCTCCTCTAGTAACCGGGCTAACCCACAGCCCCGCACAGCCACC
CGAACCCAGCAGGAAAAGCTTGGGTTTCTGCACACTAACTTCAGATTCCAGCCTCGGGTGAATCCTGTGGTCCCTGACTATGAGGGCCTT
TACAAGGCCTTCCAGAGAAGAGCAGCCAAAAGAAGAGAAACCCAAGAGGCCACTCGCAACAAGCCCTTCTTGCTGAGGACCGCCAACCTG
CGCCACCCTCAGCGGCCCTGTGATGCTGCCACCACCGGAAGGAGGCAGGATTCCCCACAGCCACCAGCTACACCCCTGCCAAGGAGTCGT
TCTCTGAGCGGCCTTGCTTCCCTCTCTGCCAACACTCTCCCTGTGCACATCACAGATGCCACCAGGAAGAGGGAATCTGCAGTCAGAAGT
GCACTTGAAAAAAAGAACAAAGCAGATGAGAGTATTCAGTGGCTGGAGATACACAAAAAGAAGTCTCAAGCAATGTCCAAATCTGTGACC
TTGCGTGCAAAAGCCATGGATCCCCATAAAAGCCTGGAGGAAGTGTTCAAAGCAAAGCTGAAAGAGAACCGGAACAATGACCGTAAAAGA
GCGAAAGAATATAAGAAAGAACTGGAGGAAATGAAGCAGCGAATACAAACAAGGCCCTATCTCTTTGAACAAGTTGCCAAGGATCTAGCC
AAGAAAGAAGCAGAACAGTGGTATCTAGACACCCTGAAGCAGGCTGGGCTGGAGGAAGACTTTGTGAGAAACAAGGGTCAAGGCACCCGG
GCTGTTCAAGAGAAAGAGACCAAAATCAAGGATTTTCCCAGGTTCCAAGAAACTACAAAACTCAGCATCAGAGATCCAGAGCAGGGTTTA
GAAGGATCTCTAGAACAGCCTGCAAGCCCCAGGAAAGTACTGGAGGAGCTGTCTCATCAGTCACCAGAAAATCTCGTATCACTTGCTTAA
TCACTACACTTAAAATTACTGCTTTTGAAAAATATTAAGCAGCTAACTTGGGTTTGAGTCAAGGCAGGGAAAACTTGGGTTTTGAGTCAT
GGCTACTGTTAGAGGATGGACAAATGAAGAGTAGCAGATTAACAGGCCAGGCGCAGTGGCTCACGCCTGTAATCCCAACACTTTGGGAGG
CTGAGGCAGGCAGATCATCTGAGGTCAGGAGTTTGAGACCAGTCCAGCCAACACGGCAAAACTCCACCTCTACT

>10768_10768_6_C11orf80-FAM161B_C11orf80_chr11_66526567_ENST00000525449_FAM161B_chr14_74409418_ENST00000534936_length(amino acids)=435AA_BP=27
MLEGQLVISIEGLNSKHQANALHCVTTRWSLTLLPRPECSGAVSAHCNLHLPGSSDSHASVPRVAGITDAHHHAWLIMVASAGSLFGGMV
LKKFLKEAELFRKIRIQMRALDMLQMASSPIASSSNRANPQPRTATRTQQEKLGFLHTNFRFQPRVNPVVPDYEGLYKAFQRRAAKRRET
QEATRNKPFLLRTANLRHPQRPCDAATTGRRQDSPQPPATPLPRSRSLSGLASLSANTLPVHITDATRKRESAVRSALEKKNKADESIQW
LEIHKKKSQAMSKSVTLRAKAMDPHKSLEEVFKAKLKENRNNDRKRAKEYKKELEEMKQRIQTRPYLFEQVAKDLAKKEAEQWYLDTLKQ
AGLEEDFVRNKGQGTRAVQEKETKIKDFPRFQETTKLSIRDPEQGLEGSLEQPASPRKVLEELSHQSPENLVSLA

--------------------------------------------------------------
>10768_10768_7_C11orf80-FAM161B_C11orf80_chr11_66526567_ENST00000540737_FAM161B_chr14_74409418_ENST00000286544_length(transcript)=2952nt_BP=187nt
ACTGGCGGAGTTCCAAGCCCGGGCTGAGGAGGGGGCGGCGGCGGCGGCGGCGGCGGCGGGCGGGTACCCTTCGACTGGGCGTTGCCGCTG
TTCCCTGCGCGGCATGGAGGGGACGGCCGTGGCCGTGTTCGAGTTGCTTCTGCAGGAAGCCTTTTTGGTGGCATGGTCCTCAAGAAGTTC
CTAAAAGAAGCTGAGCTCTTCAGGAAAATTCGCATCCAAATGAGAGCCCTGGACATGCTCCAGATGGCCTCTTCCCCTATCGCCTCCTCT
AGTAACCGGGCTAACCCACAGCCCCGCACAGCCACCCGAACCCAGCAGGAAAAGCTTGGGTTTCTGCACACTAACTTCAGATTCCAGCCT
CGGGTGAATCCTGTGGTCCCTGACTATGAGGGCCTTTACAAGGCCTTCCAGAGAAGAGCAGCCAAAAGAAGAGAAACCCAAGAGGCCACT
CGCAACAAGCCCTTCTTGCTGAGGACCGCCAACCTGCGCCACCCTCAGCGGCCCTGTGATGCTGCCACCACCGGAAGGAGGCAGGATTCC
CCACAGCCACCAGCTACACCCCTGCCAAGGAGTCGTTCTCTGAGCGGCCTTGCTTCCCTCTCTGCCAACACTCTCCCTGTGCACATCACA
GATGCCACCAGGAAGAGGGAATCTGCAGTCAGAAGTGCACTTGAAAAAAAGAACAAAGCAGATGAGAGTATTCAGTGGCTGGAGATACAC
AAAAAGAAGTCTCAAGCAATGTCCAAATCTGTGACCTTGCGTGCAAAAGCCATGGATCCCCATAAAAGCCTGGAGGAAGTGTTCAAAGCA
AAGCTGAAAGAGAACCGGAACAATGACCGTAAAAGAGCGAAAGAATATAAGAAAGAACTGGAGGAAATGAAGCAGCGAATACAAACAAGG
CCCTATCTCTTTGAACAAGTTGCCAAGGATCTAGCCAAGAAAGAAGCAGAACAGTGGTATCTAGACACCCTGAAGCAGGCTGGGCTGGAG
GAAGACTTTGTGAGAAACAAGGGTCAAGGCACCCGGGCTGTTCAAGAGAAAGAGACCAAAATCAAGGATTTTCCCAGGTTCCAAGAAACT
ACAAAACTCAGCATCAGAGATCCAGAGCAGGGTTTAGAAGGATCTCTAGAACAGCCTGCAAGCCCCAGGAAAGTACTGGAGGAGCTGTCT
CATCAGTCACCAGAAAATCTCGTATCACTTGCTTAATCACTACACTTAAAATTACTGCTTTTGAAAAATATTAAGCAGCTAACTTGGGTT
TGAGTCAAGGCAGGGAAAACTTGGGTTTTGAGTCATGGCTACTGTTAGAGGATGGACAAATGAAGAGTAGCAGATTAACAGGCCAGGCGC
AGTGGCTCACGCCTGTAATCCCAACACTTTGGGAGGCTGAGGCAGGCAGATCATCTGAGGTCAGGAGTTTGAGACCAGTCCAGCCAACAC
GGCAAAACTCCACCTCTACTAAAAATACAAAAATTAGCTGGGCGTGATGACACGTGCCTGTAATCCTAGCTACTTGGGAAGCTGAGGCAG
GAGAATCACTTGAACCCAAGAGGCAGAGGTTGTAATGAGCTGAGATCACTCCACAGCACTCCAGCCTGGGCAGCAGAGCAAAACTCTGTC
TGAGAAAAAAAAAGAGCAGCAGATAACAGAGAATAGTTCAAGGAAATCAAAGTGGGGAGGCTCAGGTGGAGGGATGGTAGCCTAAAGTTA
AGGGTTCCTGCTTTGTGCCTCACACTTAGAGAATTAGGTACAGAAAAGAGAGCACAGGCCCAAATGCCTATAAGGGGCTAGTGCAGAAAC
ATAAATGCGTCCATGGAGTGGGTGTAGACAGTAGGAGATAGTAGACACTGGAAAGTATCAAATCCTGCTGGAATATAGGCTCAGAGTTAC
TACATCAACTACATTTTCATCAAGCCAGAAATTTGTATGCTATCAACTAATTTAAAAATTACTTAGAAATATTGTATGGGCAAAATAAAA
TACATCTGCATATCAGATCTAGCCCATGGGGGATGAAAAACTTACAACTTCTAGTACAGGATTTCTTATCCTCAGTGCTATTAATATTTT
GGGCCACCTAATTCTTTGTTGAGGGTTGGGGAAGGGAACTGTCCTGTACATTGTAGAATGTTTAGTAGCATCCCTGGCCACTACCTGCTA
GATGCCAGTAGTACCCCTCTCCCCAGCTGTGACAACCAAAAATGTCTCCAGATATTGCATATCCCCAGGGGGCAAAAATGTGCCTGGCTG
AGAACCACTGCTCTAATATAAATGGCTGCATGAAGCAAAAACTGGCATTCTAAGAATACAAGTAATTGCCATGAACACAGTCTATGTACT
ATGTGATTATGCATGTCATTAACAAATTAAGAATTTAAAACAATTCTCTCCCGTTATCTGTTTAGAATGTGCCTGTGTGTTTATGTGAGC
ATGAGGTTCATTTTAAGTAAACTTAAAATTTCCCAGACAACCAAGATTTTCTACTAGTAGGTGAACTTTGGAATAATTTTCTTCTCACCA
ATAATAATTGGATATTCTGGCTCGGTGCAGTGGTTCATGCTTGTAATCCCAGCACTTTGAGGGGCCAAGGCAGGAGGATCGCTTGAAGCC
AGGCGTTCAAGACCAGCCTGGGCAACACAGACCTCATTTCTACCAAAAAAACCACAAAAAGTTAGCTGGACTGGTGGTACATGCCTATAG
TCCTAGCTATTCAGGAGGCTGAGGTGGGAGGATGCCTTGAGCGTAGGAGTTCAAGGTTACATTGAGCTATGATTACACTACTGCACTCCA
GCCTGGGTGACAGAGCAAGACCCCATCTCAAATCATAATGATGATGAGTGGATATTTTCTCAGTAGCTGTGGAGACAGGATGACTGATAG
CAAGAGTGCCTGCTCTAACTAAAGCACCTTTCTCAAGCTTTTTTAAAAAAACTATCTTTGTGGAAAAATTCA

>10768_10768_7_C11orf80-FAM161B_C11orf80_chr11_66526567_ENST00000540737_FAM161B_chr14_74409418_ENST00000286544_length(amino acids)=374AA_BP=30
MPLFPARHGGDGRGRVRVASAGSLFGGMVLKKFLKEAELFRKIRIQMRALDMLQMASSPIASSSNRANPQPRTATRTQQEKLGFLHTNFR
FQPRVNPVVPDYEGLYKAFQRRAAKRRETQEATRNKPFLLRTANLRHPQRPCDAATTGRRQDSPQPPATPLPRSRSLSGLASLSANTLPV
HITDATRKRESAVRSALEKKNKADESIQWLEIHKKKSQAMSKSVTLRAKAMDPHKSLEEVFKAKLKENRNNDRKRAKEYKKELEEMKQRI
QTRPYLFEQVAKDLAKKEAEQWYLDTLKQAGLEEDFVRNKGQGTRAVQEKETKIKDFPRFQETTKLSIRDPEQGLEGSLEQPASPRKVLE
ELSHQSPENLVSLA

--------------------------------------------------------------
>10768_10768_8_C11orf80-FAM161B_C11orf80_chr11_66526567_ENST00000540737_FAM161B_chr14_74409418_ENST00000534936_length(transcript)=1460nt_BP=187nt
ACTGGCGGAGTTCCAAGCCCGGGCTGAGGAGGGGGCGGCGGCGGCGGCGGCGGCGGCGGGCGGGTACCCTTCGACTGGGCGTTGCCGCTG
TTCCCTGCGCGGCATGGAGGGGACGGCCGTGGCCGTGTTCGAGTTGCTTCTGCAGGAAGCCTTTTTGGTGGCATGGTCCTCAAGAAGTTC
CTAAAAGAAGCTGAGCTCTTCAGGAAAATTCGCATCCAAATGAGAGCCCTGGACATGCTCCAGATGGCCTCTTCCCCTATCGCCTCCTCT
AGTAACCGGGCTAACCCACAGCCCCGCACAGCCACCCGAACCCAGCAGGAAAAGCTTGGGTTTCTGCACACTAACTTCAGATTCCAGCCT
CGGGTGAATCCTGTGGTCCCTGACTATGAGGGCCTTTACAAGGCCTTCCAGAGAAGAGCAGCCAAAAGAAGAGAAACCCAAGAGGCCACT
CGCAACAAGCCCTTCTTGCTGAGGACCGCCAACCTGCGCCACCCTCAGCGGCCCTGTGATGCTGCCACCACCGGAAGGAGGCAGGATTCC
CCACAGCCACCAGCTACACCCCTGCCAAGGAGTCGTTCTCTGAGCGGCCTTGCTTCCCTCTCTGCCAACACTCTCCCTGTGCACATCACA
GATGCCACCAGGAAGAGGGAATCTGCAGTCAGAAGTGCACTTGAAAAAAAGAACAAAGCAGATGAGAGTATTCAGTGGCTGGAGATACAC
AAAAAGAAGTCTCAAGCAATGTCCAAATCTGTGACCTTGCGTGCAAAAGCCATGGATCCCCATAAAAGCCTGGAGGAAGTGTTCAAAGCA
AAGCTGAAAGAGAACCGGAACAATGACCGTAAAAGAGCGAAAGAATATAAGAAAGAACTGGAGGAAATGAAGCAGCGAATACAAACAAGG
CCCTATCTCTTTGAACAAGTTGCCAAGGATCTAGCCAAGAAAGAAGCAGAACAGTGGTATCTAGACACCCTGAAGCAGGCTGGGCTGGAG
GAAGACTTTGTGAGAAACAAGGGTCAAGGCACCCGGGCTGTTCAAGAGAAAGAGACCAAAATCAAGGATTTTCCCAGGTTCCAAGAAACT
ACAAAACTCAGCATCAGAGATCCAGAGCAGGGTTTAGAAGGATCTCTAGAACAGCCTGCAAGCCCCAGGAAAGTACTGGAGGAGCTGTCT
CATCAGTCACCAGAAAATCTCGTATCACTTGCTTAATCACTACACTTAAAATTACTGCTTTTGAAAAATATTAAGCAGCTAACTTGGGTT
TGAGTCAAGGCAGGGAAAACTTGGGTTTTGAGTCATGGCTACTGTTAGAGGATGGACAAATGAAGAGTAGCAGATTAACAGGCCAGGCGC
AGTGGCTCACGCCTGTAATCCCAACACTTTGGGAGGCTGAGGCAGGCAGATCATCTGAGGTCAGGAGTTTGAGACCAGTCCAGCCAACAC
GGCAAAACTCCACCTCTACT

>10768_10768_8_C11orf80-FAM161B_C11orf80_chr11_66526567_ENST00000540737_FAM161B_chr14_74409418_ENST00000534936_length(amino acids)=374AA_BP=30
MPLFPARHGGDGRGRVRVASAGSLFGGMVLKKFLKEAELFRKIRIQMRALDMLQMASSPIASSSNRANPQPRTATRTQQEKLGFLHTNFR
FQPRVNPVVPDYEGLYKAFQRRAAKRRETQEATRNKPFLLRTANLRHPQRPCDAATTGRRQDSPQPPATPLPRSRSLSGLASLSANTLPV
HITDATRKRESAVRSALEKKNKADESIQWLEIHKKKSQAMSKSVTLRAKAMDPHKSLEEVFKAKLKENRNNDRKRAKEYKKELEEMKQRI
QTRPYLFEQVAKDLAKKEAEQWYLDTLKQAGLEEDFVRNKGQGTRAVQEKETKIKDFPRFQETTKLSIRDPEQGLEGSLEQPASPRKVLE
ELSHQSPENLVSLA

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Fusion Gene PPI Analysis for C11orf80-FAM161B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C11orf80-FAM161B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for C11orf80-FAM161B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneC11orf80C0678213Complete hydatidiform mole1ORPHANET