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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DHRS12-RASL11A (FusionGDB2 ID:HG79758TG387496)

Fusion Gene Summary for DHRS12-RASL11A

check button Fusion gene summary
Fusion gene informationFusion gene name: DHRS12-RASL11A
Fusion gene ID: hg79758tg387496
HgeneTgene
Gene symbol

DHRS12

RASL11A

Gene ID

79758

387496

Gene namedehydrogenase/reductase 12RAS like family 11 member A
SynonymsSDR40C1-
Cytomap('DHRS12')('RASL11A')

13q14.3

13q12.2

Type of geneprotein-codingprotein-coding
Descriptiondehydrogenase/reductase SDR family member 12dehydrogenase/reductase (SDR family) member 12short-chain dehydrogenase/reductase family 40C member 1ras-like protein family member 11A
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000218981, ENST00000280056, 
ENST00000444610, ENST00000490949, 
ENST00000490949, ENST00000218981, 
ENST00000280056, ENST00000444610, 
Fusion gene scores* DoF score6 X 7 X 4=1683 X 2 X 3=18
# samples 74
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DHRS12 [Title/Abstract] AND RASL11A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDHRS12(52373670)-RASL11A(27845621), # samples:3
Anticipated loss of major functional domain due to fusion event.DHRS12-RASL11A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DHRS12-RASL11A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DHRS12-RASL11A seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
RASL11A-DHRS12 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DHRS12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across RASL11A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-GC-A3RC-01ADHRS12chr13

52373670

-RASL11Achr13

27845621

+
ChimerDB4BLCATCGA-GC-A3RCDHRS12chr13

52373669

-RASL11Achr13

27845620

+


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Fusion Gene ORF analysis for DHRS12-RASL11A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000218981ENST00000480803DHRS12chr13

52373670

-RASL11Achr13

27845621

+
5CDS-intronENST00000218981ENST00000480803DHRS12chr13

52373669

-RASL11Achr13

27845620

+
5CDS-intronENST00000280056ENST00000480803DHRS12chr13

52373670

-RASL11Achr13

27845621

+
5CDS-intronENST00000280056ENST00000480803DHRS12chr13

52373669

-RASL11Achr13

27845620

+
5CDS-intronENST00000444610ENST00000480803DHRS12chr13

52373670

-RASL11Achr13

27845621

+
5CDS-intronENST00000444610ENST00000480803DHRS12chr13

52373669

-RASL11Achr13

27845620

+
5UTR-3CDSENST00000490949ENST00000241463DHRS12chr13

52373670

-RASL11Achr13

27845621

+
5UTR-3CDSENST00000490949ENST00000241463DHRS12chr13

52373669

-RASL11Achr13

27845620

+
5UTR-intronENST00000490949ENST00000480803DHRS12chr13

52373670

-RASL11Achr13

27845621

+
5UTR-intronENST00000490949ENST00000480803DHRS12chr13

52373669

-RASL11Achr13

27845620

+
Frame-shiftENST00000218981ENST00000241463DHRS12chr13

52373670

-RASL11Achr13

27845621

+
Frame-shiftENST00000218981ENST00000241463DHRS12chr13

52373669

-RASL11Achr13

27845620

+
Frame-shiftENST00000280056ENST00000241463DHRS12chr13

52373670

-RASL11Achr13

27845621

+
Frame-shiftENST00000280056ENST00000241463DHRS12chr13

52373669

-RASL11Achr13

27845620

+
In-frameENST00000444610ENST00000241463DHRS12chr13

52373670

-RASL11Achr13

27845621

+
In-frameENST00000444610ENST00000241463DHRS12chr13

52373669

-RASL11Achr13

27845620

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000444610DHRS12chr1352373670-ENST00000241463RASL11Achr1327845621+100520414808264
ENST00000444610DHRS12chr1352373669-ENST00000241463RASL11Achr1327845620+100520414808264

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000444610ENST00000241463DHRS12chr1352373670-RASL11Achr1327845621+0.0064320480.993568
ENST00000444610ENST00000241463DHRS12chr1352373669-RASL11Achr1327845620+0.0064320480.993568

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Fusion Genomic Features for DHRS12-RASL11A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DHRS12chr1352373669-RASL11Achr1327845620+0.0134736290.9865263
DHRS12chr1352373669-RASL11Achr1327845620+0.0134736290.9865263
DHRS12chr1352373669-RASL11Achr1327845620+0.0134736290.9865263
DHRS12chr1352373669-RASL11Achr1327845620+0.0134736290.9865263

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DHRS12-RASL11A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:52373670/chr13:27845621)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDHRS12chr13:52373669chr13:27845620ENST00000444610-21047_5363318.0Nucleotide bindingNAD or NADP
HgeneDHRS12chr13:52373670chr13:27845621ENST00000444610-21047_5363318.0Nucleotide bindingNAD or NADP
TgeneRASL11Achr13:52373669chr13:27845620ENST0000024146304147_15041243.0Nucleotide bindingGTP
TgeneRASL11Achr13:52373669chr13:27845620ENST000002414630481_8541243.0Nucleotide bindingGTP
TgeneRASL11Achr13:52373670chr13:27845621ENST0000024146304147_15041243.0Nucleotide bindingGTP
TgeneRASL11Achr13:52373670chr13:27845621ENST000002414630481_8541243.0Nucleotide bindingGTP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDHRS12chr13:52373669chr13:27845620ENST00000218981-2847_5342243.0Nucleotide bindingNAD or NADP
HgeneDHRS12chr13:52373669chr13:27845620ENST00000280056-2847_5342272.0Nucleotide bindingNAD or NADP
HgeneDHRS12chr13:52373670chr13:27845621ENST00000218981-2847_5342243.0Nucleotide bindingNAD or NADP
HgeneDHRS12chr13:52373670chr13:27845621ENST00000280056-2847_5342272.0Nucleotide bindingNAD or NADP
TgeneRASL11Achr13:52373669chr13:27845620ENST000002414630434_4141243.0Nucleotide bindingGTP
TgeneRASL11Achr13:52373670chr13:27845621ENST000002414630434_4141243.0Nucleotide bindingGTP
TgeneRASL11Achr13:52373669chr13:27845620ENST000002414630417_24141243.0RegionNote=Small GTPase-like
TgeneRASL11Achr13:52373670chr13:27845621ENST000002414630417_24141243.0RegionNote=Small GTPase-like


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Fusion Gene Sequence for DHRS12-RASL11A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>22566_22566_1_DHRS12-RASL11A_DHRS12_chr13_52373669_ENST00000444610_RASL11A_chr13_27845620_ENST00000241463_length(transcript)=1005nt_BP=204nt
GGGGCGCTCCCGGCATGTCCCTGTACCGCAGCGTCGTGTGGTTCGCCAAGGGGCTGCGCGAGTACACCAAGAGTGGCTATGAATCTGCAT
GTAAAGACTTTGTCCCTCATGACTTGGAGGTCCAGATTCCTGGAAGAGTCTTTTTGGTCACTGGAGGAAACAGCGGCATTGGCAAAGCAA
CTGCCCTTGAAATCGCCAAGCGAGCAATGATCGTGCGCTTCCTGACCAAGAGATTCATTGGAGACTATGAACCGAATACAGGCAAGCTGT
ATTCACGGCTGGTCTATGTCGAGGGGGACCAGCTCTCCCTGCAGATCCAGGATACTCCCGGGGGCGTCCAGATCCAAGACAGCCTCCCCC
AGGTCGTCGATTCCCTGTCCAAATGCGTGCAGTGGGCCGAGGGTTTTCTGCTGGTCTATTCCATCACAGACTATGACAGCTACTTGTCCA
TCCGACCCCTTTATCAGCACATCCGGAAGGTCCACCCTGACTCTAAAGCCCCTGTCATCATCGTGGGCAACAAGGGGGACCTTTTGCATG
CCCGGCAGGTGCAGACACAGGACGGTATTCAGCTAGCCAATGAGCTGGGCAGCCTGTTCCTTGAAATTTCCACTAGCGAAAACTACGAAG
ATGTCTGTGATGTGTTTCAGCATCTCTGCAAAGAAGTGAGCAAGATGCACGGCCTCAGTGGGGAAAGAAGAAGAGCCTCCATCATCCCTC
GGCCCCGCTCTCCCAACATGCAGGACCTGAAGAGACGCTTCAAGCAGGCTCTGTCTCCCAAAGTCAAAGCCCCCTCTGCACTGGGGTGAA
CTATCTCAGACAGATGCCTCTCCTTTTTAATACGCATTTGTGCAGCTAAAAGACTGGGCTTCTCGCTTTTTAATCACACATTCAGAGTTT
ATTTTTATAAAAAAATTGATTTTCAAGTACATGTGTATTTCTGAAAATTCAAACAGTGATTGCCTAGAAGCTGGATAAAATTTTGTTTTG

>22566_22566_1_DHRS12-RASL11A_DHRS12_chr13_52373669_ENST00000444610_RASL11A_chr13_27845620_ENST00000241463_length(amino acids)=264AA_BP=63
MSLYRSVVWFAKGLREYTKSGYESACKDFVPHDLEVQIPGRVFLVTGGNSGIGKATALEIAKRAMIVRFLTKRFIGDYEPNTGKLYSRLV
YVEGDQLSLQIQDTPGGVQIQDSLPQVVDSLSKCVQWAEGFLLVYSITDYDSYLSIRPLYQHIRKVHPDSKAPVIIVGNKGDLLHARQVQ

--------------------------------------------------------------
>22566_22566_2_DHRS12-RASL11A_DHRS12_chr13_52373670_ENST00000444610_RASL11A_chr13_27845621_ENST00000241463_length(transcript)=1005nt_BP=204nt
GGGGCGCTCCCGGCATGTCCCTGTACCGCAGCGTCGTGTGGTTCGCCAAGGGGCTGCGCGAGTACACCAAGAGTGGCTATGAATCTGCAT
GTAAAGACTTTGTCCCTCATGACTTGGAGGTCCAGATTCCTGGAAGAGTCTTTTTGGTCACTGGAGGAAACAGCGGCATTGGCAAAGCAA
CTGCCCTTGAAATCGCCAAGCGAGCAATGATCGTGCGCTTCCTGACCAAGAGATTCATTGGAGACTATGAACCGAATACAGGCAAGCTGT
ATTCACGGCTGGTCTATGTCGAGGGGGACCAGCTCTCCCTGCAGATCCAGGATACTCCCGGGGGCGTCCAGATCCAAGACAGCCTCCCCC
AGGTCGTCGATTCCCTGTCCAAATGCGTGCAGTGGGCCGAGGGTTTTCTGCTGGTCTATTCCATCACAGACTATGACAGCTACTTGTCCA
TCCGACCCCTTTATCAGCACATCCGGAAGGTCCACCCTGACTCTAAAGCCCCTGTCATCATCGTGGGCAACAAGGGGGACCTTTTGCATG
CCCGGCAGGTGCAGACACAGGACGGTATTCAGCTAGCCAATGAGCTGGGCAGCCTGTTCCTTGAAATTTCCACTAGCGAAAACTACGAAG
ATGTCTGTGATGTGTTTCAGCATCTCTGCAAAGAAGTGAGCAAGATGCACGGCCTCAGTGGGGAAAGAAGAAGAGCCTCCATCATCCCTC
GGCCCCGCTCTCCCAACATGCAGGACCTGAAGAGACGCTTCAAGCAGGCTCTGTCTCCCAAAGTCAAAGCCCCCTCTGCACTGGGGTGAA
CTATCTCAGACAGATGCCTCTCCTTTTTAATACGCATTTGTGCAGCTAAAAGACTGGGCTTCTCGCTTTTTAATCACACATTCAGAGTTT
ATTTTTATAAAAAAATTGATTTTCAAGTACATGTGTATTTCTGAAAATTCAAACAGTGATTGCCTAGAAGCTGGATAAAATTTTGTTTTG

>22566_22566_2_DHRS12-RASL11A_DHRS12_chr13_52373670_ENST00000444610_RASL11A_chr13_27845621_ENST00000241463_length(amino acids)=264AA_BP=63
MSLYRSVVWFAKGLREYTKSGYESACKDFVPHDLEVQIPGRVFLVTGGNSGIGKATALEIAKRAMIVRFLTKRFIGDYEPNTGKLYSRLV
YVEGDQLSLQIQDTPGGVQIQDSLPQVVDSLSKCVQWAEGFLLVYSITDYDSYLSIRPLYQHIRKVHPDSKAPVIIVGNKGDLLHARQVQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DHRS12-RASL11A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DHRS12-RASL11A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DHRS12-RASL11A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0009402Colorectal Carcinoma1CTD_human
TgeneC0009404Colorectal Neoplasms1CTD_human
TgeneC0014175Endometriosis1CTD_human
TgeneC0269102Endometrioma1CTD_human