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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:C12orf49-SRRM4 (FusionGDB2 ID:HG79794TG84530) |
Fusion Gene Summary for C12orf49-SRRM4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: C12orf49-SRRM4 | Fusion gene ID: hg79794tg84530 | Hgene | Tgene | Gene symbol | C12orf49 | SRRM4 | Gene ID | 79794 | 84530 |
| Gene name | chromosome 12 open reading frame 49 | serine/arginine repetitive matrix 4 | |
| Synonyms | - | KIAA1853|MU-MB-2.76|nSR100 | |
| Cytomap | ('C12orf49')('SRRM4') 12q24.22 | 12q24.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | UPF0454 protein C12orf49 | serine/arginine repetitive matrix protein 4medulloblastoma antigen MU-MB-2.76neural-specific SR-related protein of 100 kDaneural-specific serine/arginine repetitive splicing factor of 100 kDa | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000261318, ENST00000536380, ENST00000548356, | ||
| Fusion gene scores | * DoF score | 8 X 4 X 2=64 | 5 X 6 X 4=120 |
| # samples | 6 | 5 | |
| ** MAII score | log2(6/64*10)=-0.0931094043914815 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/120*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: C12orf49 [Title/Abstract] AND SRRM4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | C12orf49(117175595)-SRRM4(119600476), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | C12orf49-SRRM4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. C12orf49-SRRM4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. C12orf49-SRRM4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. C12orf49-SRRM4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SRRM4 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome | 29961578 |
| Fusion gene breakpoints across C12orf49 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across SRRM4 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | GBM | TCGA-06-5856-01A | C12orf49 | chr12 | 117175595 | - | SRRM4 | chr12 | 119583186 | + |
| ChimerDB4 | GBM | TCGA-06-5856-01A | C12orf49 | chr12 | 117175595 | - | SRRM4 | chr12 | 119600476 | + |
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Fusion Gene ORF analysis for C12orf49-SRRM4 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000261318 | ENST00000267260 | C12orf49 | chr12 | 117175595 | - | SRRM4 | chr12 | 119600476 | + |
| 5CDS-3UTR | ENST00000536380 | ENST00000267260 | C12orf49 | chr12 | 117175595 | - | SRRM4 | chr12 | 119600476 | + |
| 5CDS-intron | ENST00000261318 | ENST00000537597 | C12orf49 | chr12 | 117175595 | - | SRRM4 | chr12 | 119583186 | + |
| 5CDS-intron | ENST00000261318 | ENST00000537597 | C12orf49 | chr12 | 117175595 | - | SRRM4 | chr12 | 119600476 | + |
| 5CDS-intron | ENST00000536380 | ENST00000537597 | C12orf49 | chr12 | 117175595 | - | SRRM4 | chr12 | 119583186 | + |
| 5CDS-intron | ENST00000536380 | ENST00000537597 | C12orf49 | chr12 | 117175595 | - | SRRM4 | chr12 | 119600476 | + |
| In-frame | ENST00000261318 | ENST00000267260 | C12orf49 | chr12 | 117175595 | - | SRRM4 | chr12 | 119583186 | + |
| In-frame | ENST00000536380 | ENST00000267260 | C12orf49 | chr12 | 117175595 | - | SRRM4 | chr12 | 119583186 | + |
| intron-3CDS | ENST00000548356 | ENST00000267260 | C12orf49 | chr12 | 117175595 | - | SRRM4 | chr12 | 119583186 | + |
| intron-3UTR | ENST00000548356 | ENST00000267260 | C12orf49 | chr12 | 117175595 | - | SRRM4 | chr12 | 119600476 | + |
| intron-intron | ENST00000548356 | ENST00000537597 | C12orf49 | chr12 | 117175595 | - | SRRM4 | chr12 | 119583186 | + |
| intron-intron | ENST00000548356 | ENST00000537597 | C12orf49 | chr12 | 117175595 | - | SRRM4 | chr12 | 119600476 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000261318 | C12orf49 | chr12 | 117175595 | - | ENST00000267260 | SRRM4 | chr12 | 119583186 | + | 7590 | 272 | 161 | 1336 | 391 |
| ENST00000536380 | C12orf49 | chr12 | 117175595 | - | ENST00000267260 | SRRM4 | chr12 | 119583186 | + | 7598 | 280 | 169 | 1344 | 391 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000261318 | ENST00000267260 | C12orf49 | chr12 | 117175595 | - | SRRM4 | chr12 | 119583186 | + | 0.19890244 | 0.8010976 |
| ENST00000536380 | ENST00000267260 | C12orf49 | chr12 | 117175595 | - | SRRM4 | chr12 | 119583186 | + | 0.19790857 | 0.8020914 |
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Fusion Genomic Features for C12orf49-SRRM4 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| C12orf49 | chr12 | 117175594 | - | SRRM4 | chr12 | 119583185 | + | 9.44E-07 | 0.99999905 |
| C12orf49 | chr12 | 117175594 | - | SRRM4 | chr12 | 119583185 | + | 9.44E-07 | 0.99999905 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for C12orf49-SRRM4 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:117175595/chr12:119600476) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | C12orf49 | chr12:117175595 | chr12:119583186 | ENST00000261318 | - | 1 | 5 | 1_16 | 37 | 206.0 | Topological domain | Cytoplasmic |
| Hgene | C12orf49 | chr12:117175595 | chr12:119583186 | ENST00000261318 | - | 1 | 5 | 17_35 | 37 | 206.0 | Transmembrane | Helical |
| Tgene | SRRM4 | chr12:117175595 | chr12:119583186 | ENST00000267260 | 7 | 13 | 442_598 | 257 | 612.0 | Compositional bias | Note=Arg-rich |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | C12orf49 | chr12:117175595 | chr12:119583186 | ENST00000261318 | - | 1 | 5 | 103_135 | 37 | 206.0 | Compositional bias | Note=Cys-rich |
| Hgene | C12orf49 | chr12:117175595 | chr12:119583186 | ENST00000261318 | - | 1 | 5 | 36_205 | 37 | 206.0 | Topological domain | Lumenal |
| Tgene | SRRM4 | chr12:117175595 | chr12:119583186 | ENST00000267260 | 7 | 13 | 109_171 | 257 | 612.0 | Compositional bias | Note=Lys-rich | |
| Tgene | SRRM4 | chr12:117175595 | chr12:119583186 | ENST00000267260 | 7 | 13 | 123_608 | 257 | 612.0 | Compositional bias | Note=Ser-rich |
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Fusion Gene Sequence for C12orf49-SRRM4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >10841_10841_1_C12orf49-SRRM4_C12orf49_chr12_117175595_ENST00000261318_SRRM4_chr12_119583186_ENST00000267260_length(transcript)=7590nt_BP=272nt GGGCTGCGCCCAAGGCTGCCGGGAGCAGACTGGGCTGCGGGCGGCGGGGCCGGCGCCTGCCTGGAGGGATGGGGCTGCCGGGCGCGTAGG GGCCATGCCGCCCGGGACCCGGGCCTGCCGCGTTCCGCGCCCCGGCCGCCGCGCCCCACGTCCGCGCCGGGATGGTGAACCTGGCGGCCA TGGTGTGGCGCCGGCTTCTGCGGAAGAGGTGGGTGCTCGCCCTGGTCTTCGGGCTGTCGCTCGTCTACTTCCTCAGCAGCACCTTCAAGC AGATCACTGGGTCGGGGTCTGCTGCTGACCTCTTTACCAAAACAGCCAGCCCGCTCACCACCTCGCGAGGACGTTCCCAGGAGTACGACT CAGGAAATGACACGTCCTCGCCACCCTCCACGCAAACCAGCTCAGCCAGGTCTCGGGGCCAGGAGAAGGGGAGCCCCAGTGGGGGCTTGA GCAAGAGCCGGGAGCTCAACAGTGGCAACACCTCTGATTCAGGGAACTCCTTCACCACCTCCTCACCCCAGAACAAGGGGGCCATGTTGG AGAATCTCTCCCCCACCAGCAGGGGCAGAGAGTCAAGGGGATTTCAGTCACCGTGTCTGGAATGTGCCGAAGTGAAGAAGTCCAGTTTGG TCCCATCCACAGCCCGGAGCTCACCCATGAAAGGGTGTTCCCGCAGCTCCTCCTATGCCAGCACCCGATCCTCCAGTCACTCGTCCCGAT CCCCAAATCCCAGGGCTTCCCCCAGGTACACCCAAAGCCGATCCACCTCTTCTGAAAAAAGGTCCTACTCCCGCTCTCCCAGCTATTCCT CCAAGTCTGGCAAGAGGAGCCCGCCCAGCAGAAGCTCTAGGTCCCGCCGCAGCCCTAGCTACTCCCGCTACAGCCCCAGCAGGGAGCGGG ATCCCAAATACAGTGAGAAGGACTCGCAGCAGCGGGAGCGCGAGCGAGCGCGTCGGAGACGTCGGTCCTACTCGCCTATGAGAAAGCGCC GGAGAGACTCCCCGAGCCACCTGGAGGCCCGGAGGATAACCAGTGCCCGGAAACGCCCCATCCCCTACTATCGGCCCAGCCCCTCCTCAT CCGGCAGCCTCAGCAGCACCTCCTCCTGGTACAGCAGCAGCAGTAGCCGCTCGGCCAGCCGCAGCTACTCCCGGAGCCGGAGTCGGAGCC GGAGCCGGAGACGGAGCCGGACCCGCACGAGCAGCAGCTCTAGCTCCCGCAGCCCTAGTCCGGGCTCCCGCAGCCGGAGCCGGAGCAGGA GCCGGAGCCGGAGCCGGAGCAGGAGCCAGAGCCGGAGCTACAGCTCAGCAGACAGCTACTCCAGCACGAGGCGCTAAGTGCCCCTGAGCC AGCTGCCCGTGGGGGCCCCTTCGCGCTGCCAGCCTCCCCCAACCACCTGCCCTCCCCGCCTTCTTGGTGACAAATAGTGAGGGCTCCTAT ACCTTGTCCTTCCTGCTTGCCTAGGGGAAGAGGAGAAGAGGGTAAGGGGGCTTCACTCTCTAGATCAGCCTGCTAGGAGCCTCTACCAGC ATCATCCTGGGGCCCAGCTCAGGCCTGGGCATATGGAAAGAACCATCATCTTGTGGCACAAAAAAAGAAGAAAGAAAAGAAAACTTCAAG GTTTTGTGAGAAGCAATGGGTCTGTGACTCAAAAATTGAGCCCTGGCCAGGAAAATGTGGAGACAGTTCTTCTCCTCCACTGCTCACAGG AGGCCCGTGGTAATTCTCCCCACCTCCCCGGATGCCCCACTAGTCCAACTTCATGGCTGCACGTGGATGGACCCCCATGTCTGAGAGGGG TGAAAGAGGAGACCAATGGCAGTTCAGGTTCAAGATAACGGGGTCAGGCCTTTAACTTCCTCAAACAGGCCCAAGCAAAGGCTGGAAGAC ATTTGGGTCCTAGAAGAAGGGATATCCTTGAATACCAGATGGGGACGTTTGACTTGGTGGGAGGTGTCAGGAGATAGGAGTTGGTTAAGA TGATAGATAGAAAAACGGAAGGGTTCAGCTGCTGCTCCCAATACCTCAGCATGGTAAGGGGACAGAGCCCAGCAGATCCCAGCTGTGAAG AGGCCACTGCATGGCTGACACAAAACACCTCTTGGCCATTCACAGGGGCCCTGCAACCTCACGAGAAAGGAGATAGTGGAAGAGTCAGGA CAGGTTGGTCTCCAGCCCCACTTCCCAAATATGCCTCAGCCCCACTAGCTGGCACCAACTTAATTCCACGGGACCATCTGCTGAACATTC CCCAGTGCCATGGCCAGTTGCCAGGCCCCAGCGCCAGCCAGTCTGGCCTTACCCTCCGGTTGGCGCCTGCCAGCCCCCTCCCCTCTGCCC AGGCTGCCACGCCCTGGATGCCACCCAGTGCAGCCTGGCACCTACCCACCCACCCTTCAGCTTAAGCCACTCCCCTTGCCTCTCAGGAAT TTTGCCAGGATGGGGCACAGCAGCTCAGGTTTGGGGGAAAAGACCCGAATCCAGAGTGCAGGGGAGAGGGGCTTGGATATGCCATGTCTT GGGCTCCTGCTGGCTTCTGAGGTTTCTTGTCAGCTTGGGAAAGACCCACCTTTATTTTTGCCCTCACCCCAAGTCCCCCCTGGCTGGGGC TGGGCAGAGAGGGTAAGCTGATCTCCGATCCACAAATACCACCAGCTGCTTCATCCACAGAAGGCGCTAAGAACGGGGAGGTGAGGAATA AGATCCTTAAAATAAACTCTTGGGCATCCCCCTCACCAGCTGACTGGCTTTCCGGAGGCTTGTGGGTGAGTTTCAAGTTTGTGGTGGCAA CAGCAGCAGGACAGGGCACGGAGGGAGCGAGGGAGAGAGGACCGGTCCCAGCTTTTGGATATTTTGGGTTATGGGGAAGCAAGGGCCAAA CATTCTTTATCCCTCCCACCCCAGGGAAAACATTTGGAAAATAGTCCTTTTTCTTGGAAGCAGTGACGTCTCCCTACCCAATCTTTCCCA TCCTATCAACCCATGGGGCTAGAGACTGCCATGCAACCACCACCACGACAGCCCTTCCTCCATCAGAAGACAGGAGTGAGGGCCCCGGGC AGCAGTGGACGACCCAGCCTCCCCATACCGGGCCTCTGGCCCAGACCTAAGCCCTGCCCACAAAGACTAATGGATGCCAGTGCTGTCACT GCAGAAGGCCAGATGGCAGGTGCCTGGGACAGGGGCAGGTGCCCCGGGGAGGGCAAGTACAGCCACTGTAAATAACCCTCGTCCCTGCCC AGGAACCCAGACTGGACTTCAGTCTCCCTCCATGGAGACAAAGGCTTCCCAGAGCCACCAAAAACCTTCTTAGCAGGACAGCTGTGAGAG GCATCAGAACCTCACGTTCGGACTGCCTTCATCAAGACAACTCTAGGGGACCATTTTGCCTGGGGCTCCTAGCAAACCTTTTTATTTATT TTATTTATTTATCTATTTATTTATTTGATGACTGTCTCTCTTTCTCGCCATTAGCAGTATTGAATTATTTATTTATACAGAGGTTTTGTG TGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTGGGGGGATCTCCTAAATTATTTCTGTGCATCTCCTTTTTTTT TCTGCTGTTTTTTATGGATGGGATTTGAGAGGCCAAAGGTGAGTGGGCTATTGGCCTTCTCCCTGAAGGCTCTAAGCCTGGAACACCCTG GGGTTGGCCCAGAAGGAGGCACATCAGTCCCAAAATTCATCACTTAACCCAGCGTCCAGGAGGGTCAGGCCTGTACCCCAGCCTCCTGTC CCCCAGGAACCTCACAGGGGTATCAAAAAGATGTAAACAGCCCAGAGGCTTATGAGCTACAGTGATGAATTGACACAGTGGAGTTGCAAC TTAGGTGGGGGTTGGAGTCGAAAGTTGGCAAATGGGGCCAAGGCTGCACAAAGTCGAAATCCCTTGTGAATGTCCCTTAGGGAGGCACCA GATTGGAGACAGATGTGCTATCTCCTAACAGAGTGATGAGGCTTCAGTTGAGTACTTGCTGAAGTAGTTGCCTTGTATTTTGAGGGCCAT GGTGGATGAAAATGATGTCTGGTTTAGTACTGGAATTGCACTTGGGGTTGACAAGGTGCTCACACCATGAGAATGGAGGCAGGAATTGAG CTGACTGAGGGAAGATGCACCTTGATCTCACCCTCACTCCAAGGCACATAGCAGGATCACTCCCTAGCTTCTCTGAGCACACCTAGTTGG TTTCATGTATGTTACACATGCTTCCACTCCACAGTACCTAATTTCTCTCTGTCCCCTGAGATCTGAAGGCTACCTTGGGAAGAGGCATCA GCCATCTTGCTTGAGAACCACCAAGCCAAAAGCAAAAGCTTTTATCTATGATCTCTTGCTGTTTCATCAGGGGAAAGCACAAAGCTATTT CTGAAATTAGGAAAAAAAAAAAAAAGGTGGAAGGAGCAGCCAGATGTTCCACAGGACCCCACCAAGAAGGTCATTTCCAAACCCATCCTG GAAGGGCCCAGGATCCAAAGGTCATCAGTCCTGCTTATCTGACCAACTGGCAGTGTCTTCTGGCTGCTGGCCGGAGACAGCTCTTGCCCT TTCCAAAGTCACTGTCCACTGCCTTGCAATTGCCAGCTTGTCTGGTCCAGCTTTGGGTTTGGTGAGACTTTTGCAACATCCCTGGTTGTT TCCCTGGCAATGTGACTATCCAGCCCTAACCCAAAGCAAGGGAGTGCCCCTTTCCTGGGTGAAGTTTACAAGAAGGCTGCTTAAATGCCT GCTTCGGGGAAATCTCTGCCTCTCTCTCTCTCTGTCTCTCTCTCTGTCTCTCTCTCTGTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC TCAGTGTATTTCTCTACTTTCTTTTACATTTCCTTTTTTTCTATCCAAAAACAATGTGCTTGTTGAGGCACTGGTAACCCTGATTAACCA GAACCTCCCATTCCCAGTATCGCTGTTCCTACGCCCATTTCACCCTCATTACCTTCTGCTTCCAAGGAATATGACAGATCACCAGGATGC TGCTCGTCGTGAGGATTTATCTCAAAAACCAACATCCAAAATGGGAGGGAGATGTGGCTTGAGGTCAAGCGCCATGCATCCCAAGCCTTT GACCTTCCCGCTATGGAAGTGCACTGGATGACAGAAACTGAATACATTGCTCCCTTTCCCTAGGGCAAAGTTCGACCTCTGTTAAGTGGA GGGATTTGTGAGATAAAAATTCAAAATGTTGGCCTGAGGCCTGAGAGTGTCACCAAAGACAGAGGGAGCTTCACTGAGACTCAGAGGGAA AAGGAAAAGAGCCTCAAACATTTTTAGGAGGTTGTCCATCATGAAAGTAAAAACGAAAAGCAAGATTTGATCTCCCTTCAGTTAATTAGG CAAGGCTAAGTAACTCAAAGCCCCCTATTAGTAACATTCTGGTTCACTGAGGTTTGATCATATTCCTATCTGCATTCCTTCCCTTCTTTG AAGGACAGCTGATCTTTCAGAAGCAGAATAAAATTAAGATGTTAGAACAAAGGTCTCAGTCTCAGAGAACCGCATCACTTCATTTGCTCA GACCCATCCTCTTTTGCAAAAGGGTCTGCTTGGAGAGGCCAAAATTCAGGGTGCTCTCAAAGGCAAAGAAAGCACATTGTTTTCCTTCTC CAGTCCAACTTTCATCTTTTCTTCTGCTGTTTTCTTTTCCCCTCTTCTTTTTCACAAATGTTCAAAATGGTCTCATGCGCATGTGTCTTG CCCCACTTTCCCCTTTAGCTGAACAGAAAATTTTGTCTCAGTAAAACGAAGTCAAAAAACAGGATTCCTCCAAACATGCCTCCTCCCGCA CTGGCCAGCCGAGTCCAGCTGAGAAACTTATGCTAGATTCAATGTCATTGAGCAATGCTTTATTGAAGTCTCGTTCTTCTCACTTCTGCA CCAGTGAGCCAATGATACTGACAGAAATGTCATCTCTCTTCTATCTGTGGTTGCTGTTTTTGGAGTAAAAGTTTCTGTGTGTGTTTTTTT AGTTCTTTTGATGGCTGTTGTTTTGCATTGTAAATACCATGATGGGGGACCCCCATCAGAACATGGCTTATTTAATAATTTATTTCGTAT TTATTGAGTAATATTGGGAAAAGAGAAGGACCACCTCTTTCCCTGAATTGCTATTGAGAATTGGTCCATCTCCCAGCTCCAGGTGCTGCT GTCTGCAGCAAGGGCATTACTGCCCAGGTAAGGAGTGCTAGAATCACCAAGCAAATTGAAATTGGCAGAAATGGAGGCTTCAGTCACACA AATTAGACTCAAATGGAACTAAAACACTGGTTATCTCCAGGAAAACCTCATTTAGATGGAAATTAATGGAAGAATAAAATGCCTACACAT GAACCAACTTCTATTAAAAAGTCACAACTCCTTGAAAAAAAAAATAAAGAAAAATTGTAAACTCTTTTTTTTTTCTGGCCAAGGAAAGCT ATGCCTCATCTTCTAACGAGCCAAGCCAAAAAGACTGCAATGGTATTCCTATGTGTTTCTTTGGCCTGTGTATCAGTCTGAATGAAATGG AATGGGTCTCTAGCCTCAGTCTTGTCATCTGTAAAATGGGGCTTGTCCTATATATTATCTGCAAGACGTGGGAAATGGGGGCTCAAGCCC TGATGCTATGGACTCCATACTGTTGGATATATTGTCTCTTGTGTCTTCTGCTGACTGCAGATTAAAGGGTGTCAACCAAGGAAGGAAACA AAAAAGTAGGGCCTGGACTTCATTTGCAGAATGAGGTCATAGTCGTTGAGTCCCACAGTCATATATGGGAGACCTCAAGTTGCTGTCACC TTGATAACTCTTGTATCCTGGGTTAAAGCCCTCTGTATTTAGTTTGAACTTCTCTCTAAGCCCCGTGGTCCAAAGTCATCACGGGAGAGA CCAAGATGGGCTTACCTTGCCCTGCTCTGGATTTAACCATTGTTCATTGTCAGGCTATATTTTTGTACAATCATTCAAATAACCCAGTGA CATAGGTCATATTGCCACTTTTCAGAGGAGAAAACTGAGGCTCAGGAGGGGGAGTTGACATGCCCAAGCTCCCTTGAGCTCAGATCAGCT TGACTCAATGTCCAACATTCCCTTGGTAGCTTTTTCTCCGGGGTCCTGTGCTATAAGAACTTCTCTCTGCACTGTATTTTTTTTTCTCCC AATTCTTAGCTATTTCCTCAAGCAATGATTGGCCAAGGACCTAGCATAATCCACCACATTGGCCAAGGGGACGTGGTGCACCCCAAGGCC ATTTCTCTGCATTGGAGGCTGCGAATCTCCTCTGGAAAATTCCCAACCCGAGGACCCACCATGAGCCCAGCTCAGCCTGACCAGACAGCC TCTGCCTGGAGCATTCACATCAGATGGAAAGAAGCTGCTGTGTCCTCCAGCATCCTGGGACCCTGTCCTCTGCCCAGTGACACAGCAGCC ATGGCTAGCTTGATTTCTGGTCTCCAAAGCTAAGCATAACCTTCCCGGGGTTTCTGGTTTTTCAGCCTGTACGAAACATGTCTCTGTTCT >10841_10841_1_C12orf49-SRRM4_C12orf49_chr12_117175595_ENST00000261318_SRRM4_chr12_119583186_ENST00000267260_length(amino acids)=391AA_BP=36 MVNLAAMVWRRLLRKRWVLALVFGLSLVYFLSSTFKQITGSGSAADLFTKTASPLTTSRGRSQEYDSGNDTSSPPSTQTSSARSRGQEKG SPSGGLSKSRELNSGNTSDSGNSFTTSSPQNKGAMLENLSPTSRGRESRGFQSPCLECAEVKKSSLVPSTARSSPMKGCSRSSSYASTRS SSHSSRSPNPRASPRYTQSRSTSSEKRSYSRSPSYSSKSGKRSPPSRSSRSRRSPSYSRYSPSRERDPKYSEKDSQQRERERARRRRRSY SPMRKRRRDSPSHLEARRITSARKRPIPYYRPSPSSSGSLSSTSSWYSSSSSRSASRSYSRSRSRSRSRRRSRTRTSSSSSSRSPSPGSR -------------------------------------------------------------- >10841_10841_2_C12orf49-SRRM4_C12orf49_chr12_117175595_ENST00000536380_SRRM4_chr12_119583186_ENST00000267260_length(transcript)=7598nt_BP=280nt GTCACGTGGGGCTGCGCCCAAGGCTGCCGGGAGCAGACTGGGCTGCGGGCGGCGGGGCCGGCGCCTGCCTGGAGGGATGGGGCTGCCGGG CGCGTAGGGGCCATGCCGCCCGGGACCCGGGCCTGCCGCGTTCCGCGCCCCGGCCGCCGCGCCCCACGTCCGCGCCGGGATGGTGAACCT GGCGGCCATGGTGTGGCGCCGGCTTCTGCGGAAGAGGTGGGTGCTCGCCCTGGTCTTCGGGCTGTCGCTCGTCTACTTCCTCAGCAGCAC CTTCAAGCAGATCACTGGGTCGGGGTCTGCTGCTGACCTCTTTACCAAAACAGCCAGCCCGCTCACCACCTCGCGAGGACGTTCCCAGGA GTACGACTCAGGAAATGACACGTCCTCGCCACCCTCCACGCAAACCAGCTCAGCCAGGTCTCGGGGCCAGGAGAAGGGGAGCCCCAGTGG GGGCTTGAGCAAGAGCCGGGAGCTCAACAGTGGCAACACCTCTGATTCAGGGAACTCCTTCACCACCTCCTCACCCCAGAACAAGGGGGC CATGTTGGAGAATCTCTCCCCCACCAGCAGGGGCAGAGAGTCAAGGGGATTTCAGTCACCGTGTCTGGAATGTGCCGAAGTGAAGAAGTC CAGTTTGGTCCCATCCACAGCCCGGAGCTCACCCATGAAAGGGTGTTCCCGCAGCTCCTCCTATGCCAGCACCCGATCCTCCAGTCACTC GTCCCGATCCCCAAATCCCAGGGCTTCCCCCAGGTACACCCAAAGCCGATCCACCTCTTCTGAAAAAAGGTCCTACTCCCGCTCTCCCAG CTATTCCTCCAAGTCTGGCAAGAGGAGCCCGCCCAGCAGAAGCTCTAGGTCCCGCCGCAGCCCTAGCTACTCCCGCTACAGCCCCAGCAG GGAGCGGGATCCCAAATACAGTGAGAAGGACTCGCAGCAGCGGGAGCGCGAGCGAGCGCGTCGGAGACGTCGGTCCTACTCGCCTATGAG AAAGCGCCGGAGAGACTCCCCGAGCCACCTGGAGGCCCGGAGGATAACCAGTGCCCGGAAACGCCCCATCCCCTACTATCGGCCCAGCCC CTCCTCATCCGGCAGCCTCAGCAGCACCTCCTCCTGGTACAGCAGCAGCAGTAGCCGCTCGGCCAGCCGCAGCTACTCCCGGAGCCGGAG TCGGAGCCGGAGCCGGAGACGGAGCCGGACCCGCACGAGCAGCAGCTCTAGCTCCCGCAGCCCTAGTCCGGGCTCCCGCAGCCGGAGCCG GAGCAGGAGCCGGAGCCGGAGCCGGAGCAGGAGCCAGAGCCGGAGCTACAGCTCAGCAGACAGCTACTCCAGCACGAGGCGCTAAGTGCC CCTGAGCCAGCTGCCCGTGGGGGCCCCTTCGCGCTGCCAGCCTCCCCCAACCACCTGCCCTCCCCGCCTTCTTGGTGACAAATAGTGAGG GCTCCTATACCTTGTCCTTCCTGCTTGCCTAGGGGAAGAGGAGAAGAGGGTAAGGGGGCTTCACTCTCTAGATCAGCCTGCTAGGAGCCT CTACCAGCATCATCCTGGGGCCCAGCTCAGGCCTGGGCATATGGAAAGAACCATCATCTTGTGGCACAAAAAAAGAAGAAAGAAAAGAAA ACTTCAAGGTTTTGTGAGAAGCAATGGGTCTGTGACTCAAAAATTGAGCCCTGGCCAGGAAAATGTGGAGACAGTTCTTCTCCTCCACTG CTCACAGGAGGCCCGTGGTAATTCTCCCCACCTCCCCGGATGCCCCACTAGTCCAACTTCATGGCTGCACGTGGATGGACCCCCATGTCT GAGAGGGGTGAAAGAGGAGACCAATGGCAGTTCAGGTTCAAGATAACGGGGTCAGGCCTTTAACTTCCTCAAACAGGCCCAAGCAAAGGC TGGAAGACATTTGGGTCCTAGAAGAAGGGATATCCTTGAATACCAGATGGGGACGTTTGACTTGGTGGGAGGTGTCAGGAGATAGGAGTT GGTTAAGATGATAGATAGAAAAACGGAAGGGTTCAGCTGCTGCTCCCAATACCTCAGCATGGTAAGGGGACAGAGCCCAGCAGATCCCAG CTGTGAAGAGGCCACTGCATGGCTGACACAAAACACCTCTTGGCCATTCACAGGGGCCCTGCAACCTCACGAGAAAGGAGATAGTGGAAG AGTCAGGACAGGTTGGTCTCCAGCCCCACTTCCCAAATATGCCTCAGCCCCACTAGCTGGCACCAACTTAATTCCACGGGACCATCTGCT GAACATTCCCCAGTGCCATGGCCAGTTGCCAGGCCCCAGCGCCAGCCAGTCTGGCCTTACCCTCCGGTTGGCGCCTGCCAGCCCCCTCCC CTCTGCCCAGGCTGCCACGCCCTGGATGCCACCCAGTGCAGCCTGGCACCTACCCACCCACCCTTCAGCTTAAGCCACTCCCCTTGCCTC TCAGGAATTTTGCCAGGATGGGGCACAGCAGCTCAGGTTTGGGGGAAAAGACCCGAATCCAGAGTGCAGGGGAGAGGGGCTTGGATATGC CATGTCTTGGGCTCCTGCTGGCTTCTGAGGTTTCTTGTCAGCTTGGGAAAGACCCACCTTTATTTTTGCCCTCACCCCAAGTCCCCCCTG GCTGGGGCTGGGCAGAGAGGGTAAGCTGATCTCCGATCCACAAATACCACCAGCTGCTTCATCCACAGAAGGCGCTAAGAACGGGGAGGT GAGGAATAAGATCCTTAAAATAAACTCTTGGGCATCCCCCTCACCAGCTGACTGGCTTTCCGGAGGCTTGTGGGTGAGTTTCAAGTTTGT GGTGGCAACAGCAGCAGGACAGGGCACGGAGGGAGCGAGGGAGAGAGGACCGGTCCCAGCTTTTGGATATTTTGGGTTATGGGGAAGCAA GGGCCAAACATTCTTTATCCCTCCCACCCCAGGGAAAACATTTGGAAAATAGTCCTTTTTCTTGGAAGCAGTGACGTCTCCCTACCCAAT CTTTCCCATCCTATCAACCCATGGGGCTAGAGACTGCCATGCAACCACCACCACGACAGCCCTTCCTCCATCAGAAGACAGGAGTGAGGG CCCCGGGCAGCAGTGGACGACCCAGCCTCCCCATACCGGGCCTCTGGCCCAGACCTAAGCCCTGCCCACAAAGACTAATGGATGCCAGTG CTGTCACTGCAGAAGGCCAGATGGCAGGTGCCTGGGACAGGGGCAGGTGCCCCGGGGAGGGCAAGTACAGCCACTGTAAATAACCCTCGT CCCTGCCCAGGAACCCAGACTGGACTTCAGTCTCCCTCCATGGAGACAAAGGCTTCCCAGAGCCACCAAAAACCTTCTTAGCAGGACAGC TGTGAGAGGCATCAGAACCTCACGTTCGGACTGCCTTCATCAAGACAACTCTAGGGGACCATTTTGCCTGGGGCTCCTAGCAAACCTTTT TATTTATTTTATTTATTTATCTATTTATTTATTTGATGACTGTCTCTCTTTCTCGCCATTAGCAGTATTGAATTATTTATTTATACAGAG GTTTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTGGGGGGATCTCCTAAATTATTTCTGTGCATCTCC TTTTTTTTTCTGCTGTTTTTTATGGATGGGATTTGAGAGGCCAAAGGTGAGTGGGCTATTGGCCTTCTCCCTGAAGGCTCTAAGCCTGGA ACACCCTGGGGTTGGCCCAGAAGGAGGCACATCAGTCCCAAAATTCATCACTTAACCCAGCGTCCAGGAGGGTCAGGCCTGTACCCCAGC CTCCTGTCCCCCAGGAACCTCACAGGGGTATCAAAAAGATGTAAACAGCCCAGAGGCTTATGAGCTACAGTGATGAATTGACACAGTGGA GTTGCAACTTAGGTGGGGGTTGGAGTCGAAAGTTGGCAAATGGGGCCAAGGCTGCACAAAGTCGAAATCCCTTGTGAATGTCCCTTAGGG AGGCACCAGATTGGAGACAGATGTGCTATCTCCTAACAGAGTGATGAGGCTTCAGTTGAGTACTTGCTGAAGTAGTTGCCTTGTATTTTG AGGGCCATGGTGGATGAAAATGATGTCTGGTTTAGTACTGGAATTGCACTTGGGGTTGACAAGGTGCTCACACCATGAGAATGGAGGCAG GAATTGAGCTGACTGAGGGAAGATGCACCTTGATCTCACCCTCACTCCAAGGCACATAGCAGGATCACTCCCTAGCTTCTCTGAGCACAC CTAGTTGGTTTCATGTATGTTACACATGCTTCCACTCCACAGTACCTAATTTCTCTCTGTCCCCTGAGATCTGAAGGCTACCTTGGGAAG AGGCATCAGCCATCTTGCTTGAGAACCACCAAGCCAAAAGCAAAAGCTTTTATCTATGATCTCTTGCTGTTTCATCAGGGGAAAGCACAA AGCTATTTCTGAAATTAGGAAAAAAAAAAAAAAGGTGGAAGGAGCAGCCAGATGTTCCACAGGACCCCACCAAGAAGGTCATTTCCAAAC CCATCCTGGAAGGGCCCAGGATCCAAAGGTCATCAGTCCTGCTTATCTGACCAACTGGCAGTGTCTTCTGGCTGCTGGCCGGAGACAGCT CTTGCCCTTTCCAAAGTCACTGTCCACTGCCTTGCAATTGCCAGCTTGTCTGGTCCAGCTTTGGGTTTGGTGAGACTTTTGCAACATCCC TGGTTGTTTCCCTGGCAATGTGACTATCCAGCCCTAACCCAAAGCAAGGGAGTGCCCCTTTCCTGGGTGAAGTTTACAAGAAGGCTGCTT AAATGCCTGCTTCGGGGAAATCTCTGCCTCTCTCTCTCTCTGTCTCTCTCTCTGTCTCTCTCTCTGTCTCTCTCTCTCTCTCTCTCTCTC TCTCTCTCTCAGTGTATTTCTCTACTTTCTTTTACATTTCCTTTTTTTCTATCCAAAAACAATGTGCTTGTTGAGGCACTGGTAACCCTG ATTAACCAGAACCTCCCATTCCCAGTATCGCTGTTCCTACGCCCATTTCACCCTCATTACCTTCTGCTTCCAAGGAATATGACAGATCAC CAGGATGCTGCTCGTCGTGAGGATTTATCTCAAAAACCAACATCCAAAATGGGAGGGAGATGTGGCTTGAGGTCAAGCGCCATGCATCCC AAGCCTTTGACCTTCCCGCTATGGAAGTGCACTGGATGACAGAAACTGAATACATTGCTCCCTTTCCCTAGGGCAAAGTTCGACCTCTGT TAAGTGGAGGGATTTGTGAGATAAAAATTCAAAATGTTGGCCTGAGGCCTGAGAGTGTCACCAAAGACAGAGGGAGCTTCACTGAGACTC AGAGGGAAAAGGAAAAGAGCCTCAAACATTTTTAGGAGGTTGTCCATCATGAAAGTAAAAACGAAAAGCAAGATTTGATCTCCCTTCAGT TAATTAGGCAAGGCTAAGTAACTCAAAGCCCCCTATTAGTAACATTCTGGTTCACTGAGGTTTGATCATATTCCTATCTGCATTCCTTCC CTTCTTTGAAGGACAGCTGATCTTTCAGAAGCAGAATAAAATTAAGATGTTAGAACAAAGGTCTCAGTCTCAGAGAACCGCATCACTTCA TTTGCTCAGACCCATCCTCTTTTGCAAAAGGGTCTGCTTGGAGAGGCCAAAATTCAGGGTGCTCTCAAAGGCAAAGAAAGCACATTGTTT TCCTTCTCCAGTCCAACTTTCATCTTTTCTTCTGCTGTTTTCTTTTCCCCTCTTCTTTTTCACAAATGTTCAAAATGGTCTCATGCGCAT GTGTCTTGCCCCACTTTCCCCTTTAGCTGAACAGAAAATTTTGTCTCAGTAAAACGAAGTCAAAAAACAGGATTCCTCCAAACATGCCTC CTCCCGCACTGGCCAGCCGAGTCCAGCTGAGAAACTTATGCTAGATTCAATGTCATTGAGCAATGCTTTATTGAAGTCTCGTTCTTCTCA CTTCTGCACCAGTGAGCCAATGATACTGACAGAAATGTCATCTCTCTTCTATCTGTGGTTGCTGTTTTTGGAGTAAAAGTTTCTGTGTGT GTTTTTTTAGTTCTTTTGATGGCTGTTGTTTTGCATTGTAAATACCATGATGGGGGACCCCCATCAGAACATGGCTTATTTAATAATTTA TTTCGTATTTATTGAGTAATATTGGGAAAAGAGAAGGACCACCTCTTTCCCTGAATTGCTATTGAGAATTGGTCCATCTCCCAGCTCCAG GTGCTGCTGTCTGCAGCAAGGGCATTACTGCCCAGGTAAGGAGTGCTAGAATCACCAAGCAAATTGAAATTGGCAGAAATGGAGGCTTCA GTCACACAAATTAGACTCAAATGGAACTAAAACACTGGTTATCTCCAGGAAAACCTCATTTAGATGGAAATTAATGGAAGAATAAAATGC CTACACATGAACCAACTTCTATTAAAAAGTCACAACTCCTTGAAAAAAAAAATAAAGAAAAATTGTAAACTCTTTTTTTTTTCTGGCCAA GGAAAGCTATGCCTCATCTTCTAACGAGCCAAGCCAAAAAGACTGCAATGGTATTCCTATGTGTTTCTTTGGCCTGTGTATCAGTCTGAA TGAAATGGAATGGGTCTCTAGCCTCAGTCTTGTCATCTGTAAAATGGGGCTTGTCCTATATATTATCTGCAAGACGTGGGAAATGGGGGC TCAAGCCCTGATGCTATGGACTCCATACTGTTGGATATATTGTCTCTTGTGTCTTCTGCTGACTGCAGATTAAAGGGTGTCAACCAAGGA AGGAAACAAAAAAGTAGGGCCTGGACTTCATTTGCAGAATGAGGTCATAGTCGTTGAGTCCCACAGTCATATATGGGAGACCTCAAGTTG CTGTCACCTTGATAACTCTTGTATCCTGGGTTAAAGCCCTCTGTATTTAGTTTGAACTTCTCTCTAAGCCCCGTGGTCCAAAGTCATCAC GGGAGAGACCAAGATGGGCTTACCTTGCCCTGCTCTGGATTTAACCATTGTTCATTGTCAGGCTATATTTTTGTACAATCATTCAAATAA CCCAGTGACATAGGTCATATTGCCACTTTTCAGAGGAGAAAACTGAGGCTCAGGAGGGGGAGTTGACATGCCCAAGCTCCCTTGAGCTCA GATCAGCTTGACTCAATGTCCAACATTCCCTTGGTAGCTTTTTCTCCGGGGTCCTGTGCTATAAGAACTTCTCTCTGCACTGTATTTTTT TTTCTCCCAATTCTTAGCTATTTCCTCAAGCAATGATTGGCCAAGGACCTAGCATAATCCACCACATTGGCCAAGGGGACGTGGTGCACC CCAAGGCCATTTCTCTGCATTGGAGGCTGCGAATCTCCTCTGGAAAATTCCCAACCCGAGGACCCACCATGAGCCCAGCTCAGCCTGACC AGACAGCCTCTGCCTGGAGCATTCACATCAGATGGAAAGAAGCTGCTGTGTCCTCCAGCATCCTGGGACCCTGTCCTCTGCCCAGTGACA CAGCAGCCATGGCTAGCTTGATTTCTGGTCTCCAAAGCTAAGCATAACCTTCCCGGGGTTTCTGGTTTTTCAGCCTGTACGAAACATGTC >10841_10841_2_C12orf49-SRRM4_C12orf49_chr12_117175595_ENST00000536380_SRRM4_chr12_119583186_ENST00000267260_length(amino acids)=391AA_BP=36 MVNLAAMVWRRLLRKRWVLALVFGLSLVYFLSSTFKQITGSGSAADLFTKTASPLTTSRGRSQEYDSGNDTSSPPSTQTSSARSRGQEKG SPSGGLSKSRELNSGNTSDSGNSFTTSSPQNKGAMLENLSPTSRGRESRGFQSPCLECAEVKKSSLVPSTARSSPMKGCSRSSSYASTRS SSHSSRSPNPRASPRYTQSRSTSSEKRSYSRSPSYSSKSGKRSPPSRSSRSRRSPSYSRYSPSRERDPKYSEKDSQQRERERARRRRRSY SPMRKRRRDSPSHLEARRITSARKRPIPYYRPSPSSSGSLSSTSSWYSSSSSRSASRSYSRSRSRSRSRRRSRTRTSSSSSSRSPSPGSR -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for C12orf49-SRRM4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for C12orf49-SRRM4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for C12orf49-SRRM4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | C0042594 | Vestibular Diseases | 1 | CTD_human | |
| Tgene | C0155536 | Paracousis | 1 | CTD_human | |
| Tgene | C0260662 | Hearing problem | 1 | CTD_human | |
| Tgene | C0877848 | Distorted hearing | 1 | CTD_human | |
| Tgene | C1510450 | Dysacusis | 1 | CTD_human |
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