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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ACTR5-IPO13 (FusionGDB2 ID:HG79913TG9670) |
Fusion Gene Summary for ACTR5-IPO13 |
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Fusion gene information | Fusion gene name: ACTR5-IPO13 | Fusion gene ID: hg79913tg9670 | Hgene | Tgene | Gene symbol | ACTR5 | IPO13 | Gene ID | 79913 | 9670 |
Gene name | actin related protein 5 | importin 13 | |
Synonyms | Arp5|INO80M | IMP13|KAP13|LGL2|RANBP13 | |
Cytomap | ('ACTR5')('IPO13') 20q11.23 | 1p34.1 | |
Type of gene | protein-coding | protein-coding | |
Description | actin-related protein 5ARP5 actin related protein 5 homologINO80 complex subunit MhARP5sarcoma antigen NY-SAR-16 | importin-13Ran binding protein 13karyopherin 13late gestation lung 2ran-binding protein 13 | |
Modification date | 20200313 | 20200327 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000243903, | ||
Fusion gene scores | * DoF score | 6 X 5 X 5=150 | 4 X 4 X 3=48 |
# samples | 6 | 4 | |
** MAII score | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ACTR5 [Title/Abstract] AND IPO13 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ACTR5(37383817)-IPO13(44423073), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | ACTR5-IPO13 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ACTR5-IPO13 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | IPO13 | GO:0006606 | protein import into nucleus | 15964792 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | STAD | TCGA-D7-A4YV | ACTR5 | chr20 | 37383817 | + | IPO13 | chr1 | 44423073 | + |
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Fusion Gene ORF analysis for ACTR5-IPO13 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000243903 | ENST00000492152 | ACTR5 | chr20 | 37383817 | + | IPO13 | chr1 | 44423073 | + |
5CDS-intron | ENST00000243903 | ENST00000372339 | ACTR5 | chr20 | 37383817 | + | IPO13 | chr1 | 44423073 | + |
In-frame | ENST00000243903 | ENST00000372343 | ACTR5 | chr20 | 37383817 | + | IPO13 | chr1 | 44423073 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000243903 | ACTR5 | chr20 | 37383817 | + | ENST00000372343 | IPO13 | chr1 | 44423073 | + | 2870 | 1030 | 1 | 2529 | 842 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000243903 | ENST00000372343 | ACTR5 | chr20 | 37383817 | + | IPO13 | chr1 | 44423073 | + | 0.005220547 | 0.99477947 |
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Fusion Genomic Features for ACTR5-IPO13 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
ACTR5 | chr20 | 37383817 | + | IPO13 | chr1 | 44423073 | + | 2.16E-06 | 0.99999785 |
ACTR5 | chr20 | 37383817 | + | IPO13 | chr1 | 44423073 | + | 2.16E-06 | 0.99999785 |
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Fusion Protein Features for ACTR5-IPO13 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:37383817/chr1:44423073) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ACTR5 | chr20:37383817 | chr1:44423073 | ENST00000243903 | + | 4 | 9 | 288_327 | 331 | 608.0 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | IPO13 | chr20:37383817 | chr1:44423073 | ENST00000372343 | 5 | 20 | 487_522 | 464 | 964.0 | Repeat | HEAT 11 | |
Tgene | IPO13 | chr20:37383817 | chr1:44423073 | ENST00000372343 | 5 | 20 | 524_558 | 464 | 964.0 | Repeat | HEAT 12 | |
Tgene | IPO13 | chr20:37383817 | chr1:44423073 | ENST00000372343 | 5 | 20 | 562_600 | 464 | 964.0 | Repeat | HEAT 13 | |
Tgene | IPO13 | chr20:37383817 | chr1:44423073 | ENST00000372343 | 5 | 20 | 603_648 | 464 | 964.0 | Repeat | HEAT 14 | |
Tgene | IPO13 | chr20:37383817 | chr1:44423073 | ENST00000372343 | 5 | 20 | 676_716 | 464 | 964.0 | Repeat | HEAT 15 | |
Tgene | IPO13 | chr20:37383817 | chr1:44423073 | ENST00000372343 | 5 | 20 | 720_754 | 464 | 964.0 | Repeat | HEAT 16 | |
Tgene | IPO13 | chr20:37383817 | chr1:44423073 | ENST00000372343 | 5 | 20 | 761_803 | 464 | 964.0 | Repeat | HEAT 17 | |
Tgene | IPO13 | chr20:37383817 | chr1:44423073 | ENST00000372343 | 5 | 20 | 815_845 | 464 | 964.0 | Repeat | HEAT 18 | |
Tgene | IPO13 | chr20:37383817 | chr1:44423073 | ENST00000372343 | 5 | 20 | 860_893 | 464 | 964.0 | Repeat | HEAT 19 | |
Tgene | IPO13 | chr20:37383817 | chr1:44423073 | ENST00000372343 | 5 | 20 | 897_931 | 464 | 964.0 | Repeat | HEAT 20 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ACTR5 | chr20:37383817 | chr1:44423073 | ENST00000243903 | + | 4 | 9 | 355_384 | 331 | 608.0 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | IPO13 | chr20:37383817 | chr1:44423073 | ENST00000372343 | 5 | 20 | 45_111 | 464 | 964.0 | Domain | Importin N-terminal | |
Tgene | IPO13 | chr20:37383817 | chr1:44423073 | ENST00000372343 | 5 | 20 | 142_179 | 464 | 964.0 | Repeat | HEAT 4 | |
Tgene | IPO13 | chr20:37383817 | chr1:44423073 | ENST00000372343 | 5 | 20 | 194_231 | 464 | 964.0 | Repeat | HEAT 5 | |
Tgene | IPO13 | chr20:37383817 | chr1:44423073 | ENST00000372343 | 5 | 20 | 236_268 | 464 | 964.0 | Repeat | HEAT 6 | |
Tgene | IPO13 | chr20:37383817 | chr1:44423073 | ENST00000372343 | 5 | 20 | 24_54 | 464 | 964.0 | Repeat | HEAT 1 | |
Tgene | IPO13 | chr20:37383817 | chr1:44423073 | ENST00000372343 | 5 | 20 | 276_325 | 464 | 964.0 | Repeat | HEAT 7 | |
Tgene | IPO13 | chr20:37383817 | chr1:44423073 | ENST00000372343 | 5 | 20 | 330_372 | 464 | 964.0 | Repeat | HEAT 8 | |
Tgene | IPO13 | chr20:37383817 | chr1:44423073 | ENST00000372343 | 5 | 20 | 375_438 | 464 | 964.0 | Repeat | HEAT 9 | |
Tgene | IPO13 | chr20:37383817 | chr1:44423073 | ENST00000372343 | 5 | 20 | 440_476 | 464 | 964.0 | Repeat | HEAT 10 | |
Tgene | IPO13 | chr20:37383817 | chr1:44423073 | ENST00000372343 | 5 | 20 | 56_88 | 464 | 964.0 | Repeat | HEAT 2 | |
Tgene | IPO13 | chr20:37383817 | chr1:44423073 | ENST00000372343 | 5 | 20 | 95_135 | 464 | 964.0 | Repeat | HEAT 3 |
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Fusion Gene Sequence for ACTR5-IPO13 |
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>1876_1876_1_ACTR5-IPO13_ACTR5_chr20_37383817_ENST00000243903_IPO13_chr1_44423073_ENST00000372343_length(transcript)=2870nt_BP=1030nt ACTGCGCCGAGGGGCGGGGCTGGACGCGCGCTCCAAGATGGCGGCGAACGTGTTCCCGTTCCGCGACGCCCGTGCCGCACCGGACCCAGT GCTGGAGGCCGGCCCGGTGGCACACGGGCCACTGCCGGTACCGCTGGTGCTGGACAACGGGTCGTTCCAAGTCCGCGCTGGCTGGGCGTG TCCCGGGCAGGACCCAGGTCCCGAGCCGCGCCTGCAGTTCCGCGCGGTGTGCGCCCGCGGTCGTGGCGGGGCACGGGGCGCGTCGGGCCC GCAGGTGGGGAACGCTCTGGGCAGCCTGGAGCCACTGCGCTGGATGCTGCGCTCGCCCTTCGACCGCAACGTGCCGGTCAACCTGGAGCT TCAGGAGTTGCTGCTGGACTACAGCTTCCAGCACCTGGGTGTCTCCTCACAGGGCTGTGTTGATCATCCCATAGTTTTGACAGAAGCTGT GTGCAACCCACTGTATTCACGGCAAATGATGTCTGAGCTTCTTTTTGAGTGCTACGGGATTCCCAAGGTTGCCTATGGAATAGACAGCCT CTTCAGCTTCTACCACAATAAGCCAAAGAACTCGATGTGCAGTGGGCTAATCATTTCATCTGGATACCAGTGTACGCATGTTTTACCCAT CTTAGAAGGGAGATTAGATGCTAAAAACTGCAAGCGCATCAATCTTGGAGGAAGCCAAGCAGCTGGTTACCTCCAGCGTCTCCTCCAGCT GAAGTACCCTGGGCACCTGGCAGCCATCACCCTCAGCCGCATGGAGGAGATTCTGCATGAGCACAGCTACATCGCTGAGGATTATGTGGA AGAATTACACAAATGGCGGTGTCCTGATTATTATGAGAATAATGTCCACAAGATGCAGCTCCCATTTTCCAGCAAGCTCCTGGGCAGCAC TCTGACCTCTGAGGAGAAACAAGAAAGGCGGCAGCAGCAATTGCGGCGGCTGCAGGAGCTCAATGCCCGGCGGCGGGAGGAGAAGCTGCA GCTGGATCAGGAGCGTCTGGACCGACTGCTATATGTGCAGCACACAGAGGCCCTCCTCTACGGCTTCCAATCCATCGCAGAGACCATTGA CGTCAACTATTCTGATGTGGTGCCTGGGCTCATTGGCCTCATCCCACGGATCAGCATCAGCAACGTGCAGCTGGCAGACACTGTCATGTT CACCATTGGAGCTCTGTCTGAATGGCTGGCTGACCACCCCGTCATGATCAACAGTGTTCTGCCCTTGGTACTGCATGCCCTAGGCAATCC TGAGCTGTCTGTCTCTTCTGTGTCCACCCTCAAGAAGATCTGCCGAGAGTGCAAGTATGACCTGCCTCCCTATGCTGCCAACATTGTGGC TGTGTCCCAGGATGTGCTGATGAAACAGATCCACAAGACAAGCCAGTGCATGTGGCTGATGCAGGCGCTGGGCTTCCTGCTGTCAGCTCT TCAAGTGGAGGAGATCCTTAAGAACCTGCACTCGCTTATCTCACCCTATATCCAGCAACTGGAGAAGCTGGCAGAGGAGATACCCAATCC CTCCAACAAGCTGGCCATTGTTCACATCTTGGGGCTTCTCTCCAACCTCTTCACCACACTGGACATCAGTCATCATGAGGATGATCATGA AGGCCCTGAGCTTCGGAAGCTGCCAGTGCCACAGGGACCCAACCCCGTGGTGGTGGTGCTGCAGCAGGTCTTCCAGCTTATCCAGAAGGT GCTGAGCAAATGGTTGAATGATGCCCAGGTTGTGGAGGCGGTGTGCGCTATCTTTGAGAAGTCTGTTAAGACGCTGCTGGATGACTTTGC CCCCATGGTGCCACAGCTGTGTGAGATGCTGGGTCGGATGTACAGCACCATCCCCCAGGCCTCTGCTCTTGACCTCACTCGACAGCTGGT CCACATCTTTGCTCATGAGCCTGCCCACTTTCCCCCAATTGAGGCCCTCTTCCTGCTCGTCACCTCCGTCACACTCACTCTCTTCCAGCA AGGGCCCAGGGATCATCCTGATATTGTTGATTCATTTATGCAACTCCTGGCACAGGCTCTGAAGCGGAAGCCAGATTTGTTCCTGTGTGA ACGATTGGATGTCAAAGCTGTGTTCCAGTGTGCTGTGCTGGCCCTCAAGTTCCCTGAGGCACCTACTGTCAAGGCCTCCTGTGGCTTCTT TACAGAGCTGCTGCCTCGGTGTGGGGAAGTAGAGTCTGTGGGAAAGGTGGTACAGGAAGACGGTCGTATGCTGCTCATAGCAGTGCTGGA GGCCATTGGGGGCCAGGCCTCCCGCAGCCTCATGGACTGCTTTGCCGATATCCTGTTCGCCCTGAACAAGCACTGCTTCAGCCTCCTGAG CATGTGGATCAAGGAGGCCCTGCAGCCACCTGGTTTCCCCTCTGCCCGCCTCAGCCCTGAACAGAAGGATACCTTCAGCCAGCAGATCCT TCGCGAGCGAGTGAACAAGAGGCGGGTGAAGGAGATGGTGAAGGAGTTCACACTGCTGTGCCGGGGTCTCCATGGCACAGATTACACAGC TGACTACTGAGGGGTGCCCCCATCCCATCCACCCCTTCTCTTCATCCTTCCCTATTCCCAAAGAGTAAACCTGGACCCTCACTGCTGTCT CTGCCTCCTTTCTGCTGTCACCACCACCTAACTGAAAGCCTGGGTCCAGAAGGCCTGGGGGAAGGATGGGAGGATGCTTGGACCCAGGCC TTGGGAGGGAATGGTGGGAACATCCTCTAGCTCCCAGGTTGGAAGAGATACTACTGTAGCCAAGCCACCTAGGCTGGAGCCCTTCAGAAT >1876_1876_1_ACTR5-IPO13_ACTR5_chr20_37383817_ENST00000243903_IPO13_chr1_44423073_ENST00000372343_length(amino acids)=842AA_BP=342 LRRGAGLDARSKMAANVFPFRDARAAPDPVLEAGPVAHGPLPVPLVLDNGSFQVRAGWACPGQDPGPEPRLQFRAVCARGRGGARGASGP QVGNALGSLEPLRWMLRSPFDRNVPVNLELQELLLDYSFQHLGVSSQGCVDHPIVLTEAVCNPLYSRQMMSELLFECYGIPKVAYGIDSL FSFYHNKPKNSMCSGLIISSGYQCTHVLPILEGRLDAKNCKRINLGGSQAAGYLQRLLQLKYPGHLAAITLSRMEEILHEHSYIAEDYVE ELHKWRCPDYYENNVHKMQLPFSSKLLGSTLTSEEKQERRQQQLRRLQELNARRREEKLQLDQERLDRLLYVQHTEALLYGFQSIAETID VNYSDVVPGLIGLIPRISISNVQLADTVMFTIGALSEWLADHPVMINSVLPLVLHALGNPELSVSSVSTLKKICRECKYDLPPYAANIVA VSQDVLMKQIHKTSQCMWLMQALGFLLSALQVEEILKNLHSLISPYIQQLEKLAEEIPNPSNKLAIVHILGLLSNLFTTLDISHHEDDHE GPELRKLPVPQGPNPVVVVLQQVFQLIQKVLSKWLNDAQVVEAVCAIFEKSVKTLLDDFAPMVPQLCEMLGRMYSTIPQASALDLTRQLV HIFAHEPAHFPPIEALFLLVTSVTLTLFQQGPRDHPDIVDSFMQLLAQALKRKPDLFLCERLDVKAVFQCAVLALKFPEAPTVKASCGFF TELLPRCGEVESVGKVVQEDGRMLLIAVLEAIGGQASRSLMDCFADILFALNKHCFSLLSMWIKEALQPPGFPSARLSPEQKDTFSQQIL -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ACTR5-IPO13 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ACTR5-IPO13 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ACTR5-IPO13 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |