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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACTR5-IPO13 (FusionGDB2 ID:HG79913TG9670)

Fusion Gene Summary for ACTR5-IPO13

check button Fusion gene summary
Fusion gene informationFusion gene name: ACTR5-IPO13
Fusion gene ID: hg79913tg9670
HgeneTgene
Gene symbol

ACTR5

IPO13

Gene ID

79913

9670

Gene nameactin related protein 5importin 13
SynonymsArp5|INO80MIMP13|KAP13|LGL2|RANBP13
Cytomap('ACTR5')('IPO13')

20q11.23

1p34.1

Type of geneprotein-codingprotein-coding
Descriptionactin-related protein 5ARP5 actin related protein 5 homologINO80 complex subunit MhARP5sarcoma antigen NY-SAR-16importin-13Ran binding protein 13karyopherin 13late gestation lung 2ran-binding protein 13
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000243903, 
Fusion gene scores* DoF score6 X 5 X 5=1504 X 4 X 3=48
# samples 64
** MAII scorelog2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACTR5 [Title/Abstract] AND IPO13 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACTR5(37383817)-IPO13(44423073), # samples:1
Anticipated loss of major functional domain due to fusion event.ACTR5-IPO13 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACTR5-IPO13 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneIPO13

GO:0006606

protein import into nucleus

15964792


check buttonFusion gene breakpoints across ACTR5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across IPO13 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-D7-A4YVACTR5chr20

37383817

+IPO13chr1

44423073

+


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Fusion Gene ORF analysis for ACTR5-IPO13

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000243903ENST00000492152ACTR5chr20

37383817

+IPO13chr1

44423073

+
5CDS-intronENST00000243903ENST00000372339ACTR5chr20

37383817

+IPO13chr1

44423073

+
In-frameENST00000243903ENST00000372343ACTR5chr20

37383817

+IPO13chr1

44423073

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000243903ACTR5chr2037383817+ENST00000372343IPO13chr144423073+2870103012529842

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000243903ENST00000372343ACTR5chr2037383817+IPO13chr144423073+0.0052205470.99477947

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Fusion Genomic Features for ACTR5-IPO13


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ACTR5chr2037383817+IPO13chr144423073+2.16E-060.99999785
ACTR5chr2037383817+IPO13chr144423073+2.16E-060.99999785

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ACTR5-IPO13


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:37383817/chr1:44423073)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACTR5chr20:37383817chr1:44423073ENST00000243903+49288_327331608.0Coiled coilOntology_term=ECO:0000255
TgeneIPO13chr20:37383817chr1:44423073ENST00000372343520487_522464964.0RepeatHEAT 11
TgeneIPO13chr20:37383817chr1:44423073ENST00000372343520524_558464964.0RepeatHEAT 12
TgeneIPO13chr20:37383817chr1:44423073ENST00000372343520562_600464964.0RepeatHEAT 13
TgeneIPO13chr20:37383817chr1:44423073ENST00000372343520603_648464964.0RepeatHEAT 14
TgeneIPO13chr20:37383817chr1:44423073ENST00000372343520676_716464964.0RepeatHEAT 15
TgeneIPO13chr20:37383817chr1:44423073ENST00000372343520720_754464964.0RepeatHEAT 16
TgeneIPO13chr20:37383817chr1:44423073ENST00000372343520761_803464964.0RepeatHEAT 17
TgeneIPO13chr20:37383817chr1:44423073ENST00000372343520815_845464964.0RepeatHEAT 18
TgeneIPO13chr20:37383817chr1:44423073ENST00000372343520860_893464964.0RepeatHEAT 19
TgeneIPO13chr20:37383817chr1:44423073ENST00000372343520897_931464964.0RepeatHEAT 20

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACTR5chr20:37383817chr1:44423073ENST00000243903+49355_384331608.0Coiled coilOntology_term=ECO:0000255
TgeneIPO13chr20:37383817chr1:44423073ENST0000037234352045_111464964.0DomainImportin N-terminal
TgeneIPO13chr20:37383817chr1:44423073ENST00000372343520142_179464964.0RepeatHEAT 4
TgeneIPO13chr20:37383817chr1:44423073ENST00000372343520194_231464964.0RepeatHEAT 5
TgeneIPO13chr20:37383817chr1:44423073ENST00000372343520236_268464964.0RepeatHEAT 6
TgeneIPO13chr20:37383817chr1:44423073ENST0000037234352024_54464964.0RepeatHEAT 1
TgeneIPO13chr20:37383817chr1:44423073ENST00000372343520276_325464964.0RepeatHEAT 7
TgeneIPO13chr20:37383817chr1:44423073ENST00000372343520330_372464964.0RepeatHEAT 8
TgeneIPO13chr20:37383817chr1:44423073ENST00000372343520375_438464964.0RepeatHEAT 9
TgeneIPO13chr20:37383817chr1:44423073ENST00000372343520440_476464964.0RepeatHEAT 10
TgeneIPO13chr20:37383817chr1:44423073ENST0000037234352056_88464964.0RepeatHEAT 2
TgeneIPO13chr20:37383817chr1:44423073ENST0000037234352095_135464964.0RepeatHEAT 3


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Fusion Gene Sequence for ACTR5-IPO13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>1876_1876_1_ACTR5-IPO13_ACTR5_chr20_37383817_ENST00000243903_IPO13_chr1_44423073_ENST00000372343_length(transcript)=2870nt_BP=1030nt
ACTGCGCCGAGGGGCGGGGCTGGACGCGCGCTCCAAGATGGCGGCGAACGTGTTCCCGTTCCGCGACGCCCGTGCCGCACCGGACCCAGT
GCTGGAGGCCGGCCCGGTGGCACACGGGCCACTGCCGGTACCGCTGGTGCTGGACAACGGGTCGTTCCAAGTCCGCGCTGGCTGGGCGTG
TCCCGGGCAGGACCCAGGTCCCGAGCCGCGCCTGCAGTTCCGCGCGGTGTGCGCCCGCGGTCGTGGCGGGGCACGGGGCGCGTCGGGCCC
GCAGGTGGGGAACGCTCTGGGCAGCCTGGAGCCACTGCGCTGGATGCTGCGCTCGCCCTTCGACCGCAACGTGCCGGTCAACCTGGAGCT
TCAGGAGTTGCTGCTGGACTACAGCTTCCAGCACCTGGGTGTCTCCTCACAGGGCTGTGTTGATCATCCCATAGTTTTGACAGAAGCTGT
GTGCAACCCACTGTATTCACGGCAAATGATGTCTGAGCTTCTTTTTGAGTGCTACGGGATTCCCAAGGTTGCCTATGGAATAGACAGCCT
CTTCAGCTTCTACCACAATAAGCCAAAGAACTCGATGTGCAGTGGGCTAATCATTTCATCTGGATACCAGTGTACGCATGTTTTACCCAT
CTTAGAAGGGAGATTAGATGCTAAAAACTGCAAGCGCATCAATCTTGGAGGAAGCCAAGCAGCTGGTTACCTCCAGCGTCTCCTCCAGCT
GAAGTACCCTGGGCACCTGGCAGCCATCACCCTCAGCCGCATGGAGGAGATTCTGCATGAGCACAGCTACATCGCTGAGGATTATGTGGA
AGAATTACACAAATGGCGGTGTCCTGATTATTATGAGAATAATGTCCACAAGATGCAGCTCCCATTTTCCAGCAAGCTCCTGGGCAGCAC
TCTGACCTCTGAGGAGAAACAAGAAAGGCGGCAGCAGCAATTGCGGCGGCTGCAGGAGCTCAATGCCCGGCGGCGGGAGGAGAAGCTGCA
GCTGGATCAGGAGCGTCTGGACCGACTGCTATATGTGCAGCACACAGAGGCCCTCCTCTACGGCTTCCAATCCATCGCAGAGACCATTGA
CGTCAACTATTCTGATGTGGTGCCTGGGCTCATTGGCCTCATCCCACGGATCAGCATCAGCAACGTGCAGCTGGCAGACACTGTCATGTT
CACCATTGGAGCTCTGTCTGAATGGCTGGCTGACCACCCCGTCATGATCAACAGTGTTCTGCCCTTGGTACTGCATGCCCTAGGCAATCC
TGAGCTGTCTGTCTCTTCTGTGTCCACCCTCAAGAAGATCTGCCGAGAGTGCAAGTATGACCTGCCTCCCTATGCTGCCAACATTGTGGC
TGTGTCCCAGGATGTGCTGATGAAACAGATCCACAAGACAAGCCAGTGCATGTGGCTGATGCAGGCGCTGGGCTTCCTGCTGTCAGCTCT
TCAAGTGGAGGAGATCCTTAAGAACCTGCACTCGCTTATCTCACCCTATATCCAGCAACTGGAGAAGCTGGCAGAGGAGATACCCAATCC
CTCCAACAAGCTGGCCATTGTTCACATCTTGGGGCTTCTCTCCAACCTCTTCACCACACTGGACATCAGTCATCATGAGGATGATCATGA
AGGCCCTGAGCTTCGGAAGCTGCCAGTGCCACAGGGACCCAACCCCGTGGTGGTGGTGCTGCAGCAGGTCTTCCAGCTTATCCAGAAGGT
GCTGAGCAAATGGTTGAATGATGCCCAGGTTGTGGAGGCGGTGTGCGCTATCTTTGAGAAGTCTGTTAAGACGCTGCTGGATGACTTTGC
CCCCATGGTGCCACAGCTGTGTGAGATGCTGGGTCGGATGTACAGCACCATCCCCCAGGCCTCTGCTCTTGACCTCACTCGACAGCTGGT
CCACATCTTTGCTCATGAGCCTGCCCACTTTCCCCCAATTGAGGCCCTCTTCCTGCTCGTCACCTCCGTCACACTCACTCTCTTCCAGCA
AGGGCCCAGGGATCATCCTGATATTGTTGATTCATTTATGCAACTCCTGGCACAGGCTCTGAAGCGGAAGCCAGATTTGTTCCTGTGTGA
ACGATTGGATGTCAAAGCTGTGTTCCAGTGTGCTGTGCTGGCCCTCAAGTTCCCTGAGGCACCTACTGTCAAGGCCTCCTGTGGCTTCTT
TACAGAGCTGCTGCCTCGGTGTGGGGAAGTAGAGTCTGTGGGAAAGGTGGTACAGGAAGACGGTCGTATGCTGCTCATAGCAGTGCTGGA
GGCCATTGGGGGCCAGGCCTCCCGCAGCCTCATGGACTGCTTTGCCGATATCCTGTTCGCCCTGAACAAGCACTGCTTCAGCCTCCTGAG
CATGTGGATCAAGGAGGCCCTGCAGCCACCTGGTTTCCCCTCTGCCCGCCTCAGCCCTGAACAGAAGGATACCTTCAGCCAGCAGATCCT
TCGCGAGCGAGTGAACAAGAGGCGGGTGAAGGAGATGGTGAAGGAGTTCACACTGCTGTGCCGGGGTCTCCATGGCACAGATTACACAGC
TGACTACTGAGGGGTGCCCCCATCCCATCCACCCCTTCTCTTCATCCTTCCCTATTCCCAAAGAGTAAACCTGGACCCTCACTGCTGTCT
CTGCCTCCTTTCTGCTGTCACCACCACCTAACTGAAAGCCTGGGTCCAGAAGGCCTGGGGGAAGGATGGGAGGATGCTTGGACCCAGGCC
TTGGGAGGGAATGGTGGGAACATCCTCTAGCTCCCAGGTTGGAAGAGATACTACTGTAGCCAAGCCACCTAGGCTGGAGCCCTTCAGAAT

>1876_1876_1_ACTR5-IPO13_ACTR5_chr20_37383817_ENST00000243903_IPO13_chr1_44423073_ENST00000372343_length(amino acids)=842AA_BP=342
LRRGAGLDARSKMAANVFPFRDARAAPDPVLEAGPVAHGPLPVPLVLDNGSFQVRAGWACPGQDPGPEPRLQFRAVCARGRGGARGASGP
QVGNALGSLEPLRWMLRSPFDRNVPVNLELQELLLDYSFQHLGVSSQGCVDHPIVLTEAVCNPLYSRQMMSELLFECYGIPKVAYGIDSL
FSFYHNKPKNSMCSGLIISSGYQCTHVLPILEGRLDAKNCKRINLGGSQAAGYLQRLLQLKYPGHLAAITLSRMEEILHEHSYIAEDYVE
ELHKWRCPDYYENNVHKMQLPFSSKLLGSTLTSEEKQERRQQQLRRLQELNARRREEKLQLDQERLDRLLYVQHTEALLYGFQSIAETID
VNYSDVVPGLIGLIPRISISNVQLADTVMFTIGALSEWLADHPVMINSVLPLVLHALGNPELSVSSVSTLKKICRECKYDLPPYAANIVA
VSQDVLMKQIHKTSQCMWLMQALGFLLSALQVEEILKNLHSLISPYIQQLEKLAEEIPNPSNKLAIVHILGLLSNLFTTLDISHHEDDHE
GPELRKLPVPQGPNPVVVVLQQVFQLIQKVLSKWLNDAQVVEAVCAIFEKSVKTLLDDFAPMVPQLCEMLGRMYSTIPQASALDLTRQLV
HIFAHEPAHFPPIEALFLLVTSVTLTLFQQGPRDHPDIVDSFMQLLAQALKRKPDLFLCERLDVKAVFQCAVLALKFPEAPTVKASCGFF
TELLPRCGEVESVGKVVQEDGRMLLIAVLEAIGGQASRSLMDCFADILFALNKHCFSLLSMWIKEALQPPGFPSARLSPEQKDTFSQQIL

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Fusion Gene PPI Analysis for ACTR5-IPO13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACTR5-IPO13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ACTR5-IPO13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource