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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ELOVL7-ELOVL7 (FusionGDB2 ID:HG79993TG79993) |
Fusion Gene Summary for ELOVL7-ELOVL7 |
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Fusion gene information | Fusion gene name: ELOVL7-ELOVL7 | Fusion gene ID: hg79993tg79993 | Hgene | Tgene | Gene symbol | ELOVL7 | ELOVL7 | Gene ID | 79993 | 79993 |
Gene name | ELOVL fatty acid elongase 7 | ELOVL fatty acid elongase 7 | |
Synonyms | - | - | |
Cytomap | ('ELOVL7')('ELOVL7') 5q12.1 | 5q12.1 | |
Type of gene | protein-coding | protein-coding | |
Description | elongation of very long chain fatty acids protein 73-keto acyl-CoA synthase ELOVL7ELOVL FA elongase 7ELOVL family member 7, elongation of long chain fatty acidsvery long chain 3-ketoacyl-CoA synthase 7very long chain 3-oxoacyl-CoA synthase 7 | elongation of very long chain fatty acids protein 73-keto acyl-CoA synthase ELOVL7ELOVL FA elongase 7ELOVL family member 7, elongation of long chain fatty acidsvery long chain 3-ketoacyl-CoA synthase 7very long chain 3-oxoacyl-CoA synthase 7 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | A1L3X0 | A1L3X0 | |
Ensembl transtripts involved in fusion gene | ENST00000425382, ENST00000438340, ENST00000505959, ENST00000508821, | ENST00000425382, ENST00000438340, ENST00000505959, ENST00000508821, | |
Fusion gene scores | * DoF score | 5 X 4 X 2=40 | 6 X 6 X 8=288 |
# samples | 4 | 12 | |
** MAII score | log2(4/40*10)=0 | log2(12/288*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ELOVL7 [Title/Abstract] AND ELOVL7 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ELOVL7(60048105)-ELOVL7(60047982), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ELOVL7 | GO:0019367 | fatty acid elongation, saturated fatty acid | 19826053 |
Hgene | ELOVL7 | GO:0034626 | fatty acid elongation, polyunsaturated fatty acid | 20937905 |
Hgene | ELOVL7 | GO:0042761 | very long-chain fatty acid biosynthetic process | 19826053|20937905 |
Tgene | ELOVL7 | GO:0019367 | fatty acid elongation, saturated fatty acid | 19826053 |
Tgene | ELOVL7 | GO:0034626 | fatty acid elongation, polyunsaturated fatty acid | 20937905 |
Tgene | ELOVL7 | GO:0042761 | very long-chain fatty acid biosynthetic process | 19826053|20937905 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Fusion Gene ORF analysis for ELOVL7-ELOVL7 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for ELOVL7-ELOVL7 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for ELOVL7-ELOVL7 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:60048105/:60047982) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
ELOVL7 | ELOVL7 |
FUNCTION: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate in the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000255|HAMAP-Rule:MF_03207, ECO:0000269|PubMed:19826053, ECO:0000269|PubMed:20937905, ECO:0000269|PubMed:21959040}. | FUNCTION: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate in the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000255|HAMAP-Rule:MF_03207, ECO:0000269|PubMed:19826053, ECO:0000269|PubMed:20937905, ECO:0000269|PubMed:21959040}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for ELOVL7-ELOVL7 |
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Fusion Gene PPI Analysis for ELOVL7-ELOVL7 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ELOVL7-ELOVL7 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ELOVL7-ELOVL7 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |