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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CALD1-PFDN6 (FusionGDB2 ID:HG800TG10471)

Fusion Gene Summary for CALD1-PFDN6

Fusion gene summary

Fusion gene information	Fusion gene name: CALD1-PFDN6
	Fusion gene ID: hg800tg10471
		Hgene	Tgene
	Gene symbol	CALD1	PFDN6
	Gene ID	800	10471
	Gene name	caldesmon 1	prefoldin subunit 6
	Synonyms	CDM\|H-CAD\|HCAD\|L-CAD\|LCAD\|NAG22	H2-KE2\|HKE2\|KE-2\|PFD6
	Cytomap	('CALD1')('PFDN6') 7q33	6p21.32
	Type of gene	protein-coding	protein-coding
	Description	caldesmontestis secretory sperm-binding protein Li 227n	prefoldin subunit 6HLA class II region expressed gene KE2KE2 protein
	Modification date	20200313	20200313
	UniProtAcc	Q05682	.
	Ensembl transtripts involved in fusion gene	ENST00000466704, ENST00000361388, ENST00000361675, ENST00000361901, ENST00000393118, ENST00000417172, ENST00000422748, ENST00000424922, ENST00000495522, ENST00000543443,
Fusion gene scores	* DoF score	20 X 22 X 11=4840	2 X 2 X 2=8
	# samples	29	2
	** MAII score	log2(29/4840*10)=-4.06088224214702 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context	PubMed: CALD1 [Title/Abstract] AND PFDN6 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CALD1(134650137)-PFDN6(33257546), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	PFDN6	GO:0051131	chaperone-mediated protein complex assembly	9630229

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A7-A6VW	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+

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Fusion Gene ORF analysis for CALD1-PFDN6

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-5UTR	ENST00000466704	ENST00000374606	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
3UTR-5UTR	ENST00000466704	ENST00000374607	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
3UTR-5UTR	ENST00000466704	ENST00000374610	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
3UTR-5UTR	ENST00000466704	ENST00000395131	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
3UTR-5UTR	ENST00000466704	ENST00000463584	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
3UTR-intron	ENST00000466704	ENST00000383207	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
3UTR-intron	ENST00000466704	ENST00000399383	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
3UTR-intron	ENST00000466704	ENST00000399385	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
3UTR-intron	ENST00000466704	ENST00000412289	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
3UTR-intron	ENST00000466704	ENST00000425878	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
3UTR-intron	ENST00000466704	ENST00000431830	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
3UTR-intron	ENST00000466704	ENST00000432391	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
3UTR-intron	ENST00000466704	ENST00000442285	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
3UTR-intron	ENST00000466704	ENST00000445559	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
3UTR-intron	ENST00000466704	ENST00000448594	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
3UTR-intron	ENST00000466704	ENST00000451970	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
3UTR-intron	ENST00000466704	ENST00000452658	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
3UTR-intron	ENST00000466704	ENST00000468094	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
3UTR-intron	ENST00000466704	ENST00000474406	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
3UTR-intron	ENST00000466704	ENST00000482292	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
3UTR-intron	ENST00000466704	ENST00000491095	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
3UTR-intron	ENST00000466704	ENST00000547641	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
3UTR-intron	ENST00000466704	ENST00000547952	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
3UTR-intron	ENST00000466704	ENST00000548040	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
3UTR-intron	ENST00000466704	ENST00000552711	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000361388	ENST00000374606	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000361388	ENST00000374607	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000361388	ENST00000374610	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000361388	ENST00000395131	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000361388	ENST00000463584	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000361675	ENST00000374606	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000361675	ENST00000374607	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000361675	ENST00000374610	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000361675	ENST00000395131	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000361675	ENST00000463584	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000361901	ENST00000374606	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000361901	ENST00000374607	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000361901	ENST00000374610	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000361901	ENST00000395131	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000361901	ENST00000463584	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000393118	ENST00000374606	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000393118	ENST00000374607	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000393118	ENST00000374610	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000393118	ENST00000395131	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000393118	ENST00000463584	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000417172	ENST00000374606	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000417172	ENST00000374607	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000417172	ENST00000374610	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000417172	ENST00000395131	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000417172	ENST00000463584	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000422748	ENST00000374606	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000422748	ENST00000374607	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000422748	ENST00000374610	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000422748	ENST00000395131	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000422748	ENST00000463584	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000424922	ENST00000374606	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000424922	ENST00000374607	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000424922	ENST00000374610	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000424922	ENST00000395131	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000424922	ENST00000463584	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000495522	ENST00000374606	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000495522	ENST00000374607	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000495522	ENST00000374610	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000495522	ENST00000395131	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000495522	ENST00000463584	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000543443	ENST00000374606	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000543443	ENST00000374607	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000543443	ENST00000374610	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000543443	ENST00000395131	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-5UTR	ENST00000543443	ENST00000463584	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361388	ENST00000383207	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361388	ENST00000399383	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361388	ENST00000399385	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361388	ENST00000412289	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361388	ENST00000425878	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361388	ENST00000431830	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361388	ENST00000432391	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361388	ENST00000442285	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361388	ENST00000445559	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361388	ENST00000448594	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361388	ENST00000451970	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361388	ENST00000452658	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361388	ENST00000468094	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361388	ENST00000474406	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361388	ENST00000482292	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361388	ENST00000491095	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361388	ENST00000547641	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361388	ENST00000547952	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361388	ENST00000548040	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361388	ENST00000552711	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361675	ENST00000383207	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361675	ENST00000399383	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361675	ENST00000399385	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361675	ENST00000412289	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361675	ENST00000425878	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361675	ENST00000431830	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361675	ENST00000432391	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361675	ENST00000442285	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361675	ENST00000445559	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361675	ENST00000448594	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361675	ENST00000451970	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361675	ENST00000452658	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361675	ENST00000468094	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361675	ENST00000474406	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361675	ENST00000482292	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361675	ENST00000491095	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361675	ENST00000547641	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361675	ENST00000547952	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361675	ENST00000548040	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361675	ENST00000552711	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361901	ENST00000383207	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361901	ENST00000399383	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361901	ENST00000399385	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361901	ENST00000412289	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361901	ENST00000425878	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361901	ENST00000431830	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361901	ENST00000432391	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361901	ENST00000442285	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361901	ENST00000445559	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361901	ENST00000448594	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361901	ENST00000451970	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361901	ENST00000452658	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361901	ENST00000468094	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361901	ENST00000474406	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361901	ENST00000482292	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361901	ENST00000491095	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361901	ENST00000547641	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361901	ENST00000547952	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361901	ENST00000548040	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000361901	ENST00000552711	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000393118	ENST00000383207	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000393118	ENST00000399383	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000393118	ENST00000399385	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000393118	ENST00000412289	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000393118	ENST00000425878	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000393118	ENST00000431830	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000393118	ENST00000432391	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000393118	ENST00000442285	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000393118	ENST00000445559	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000393118	ENST00000448594	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000393118	ENST00000451970	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000393118	ENST00000452658	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000393118	ENST00000468094	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000393118	ENST00000474406	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000393118	ENST00000482292	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000393118	ENST00000491095	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000393118	ENST00000547641	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000393118	ENST00000547952	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000393118	ENST00000548040	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000393118	ENST00000552711	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000417172	ENST00000383207	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000417172	ENST00000399383	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000417172	ENST00000399385	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000417172	ENST00000412289	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000417172	ENST00000425878	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000417172	ENST00000431830	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000417172	ENST00000432391	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000417172	ENST00000442285	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000417172	ENST00000445559	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000417172	ENST00000448594	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000417172	ENST00000451970	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000417172	ENST00000452658	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000417172	ENST00000468094	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000417172	ENST00000474406	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000417172	ENST00000482292	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000417172	ENST00000491095	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000417172	ENST00000547641	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000417172	ENST00000547952	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000417172	ENST00000548040	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000417172	ENST00000552711	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000422748	ENST00000383207	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000422748	ENST00000399383	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000422748	ENST00000399385	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000422748	ENST00000412289	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000422748	ENST00000425878	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000422748	ENST00000431830	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000422748	ENST00000432391	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000422748	ENST00000442285	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000422748	ENST00000445559	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000422748	ENST00000448594	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000422748	ENST00000451970	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000422748	ENST00000452658	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000422748	ENST00000468094	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000422748	ENST00000474406	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000422748	ENST00000482292	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000422748	ENST00000491095	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000422748	ENST00000547641	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000422748	ENST00000547952	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000422748	ENST00000548040	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000422748	ENST00000552711	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000424922	ENST00000383207	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000424922	ENST00000399383	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000424922	ENST00000399385	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000424922	ENST00000412289	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000424922	ENST00000425878	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000424922	ENST00000431830	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000424922	ENST00000432391	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000424922	ENST00000442285	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000424922	ENST00000445559	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000424922	ENST00000448594	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000424922	ENST00000451970	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000424922	ENST00000452658	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000424922	ENST00000468094	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000424922	ENST00000474406	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000424922	ENST00000482292	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000424922	ENST00000491095	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000424922	ENST00000547641	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000424922	ENST00000547952	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000424922	ENST00000548040	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000424922	ENST00000552711	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000495522	ENST00000383207	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000495522	ENST00000399383	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000495522	ENST00000399385	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000495522	ENST00000412289	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000495522	ENST00000425878	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000495522	ENST00000431830	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000495522	ENST00000432391	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000495522	ENST00000442285	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000495522	ENST00000445559	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000495522	ENST00000448594	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000495522	ENST00000451970	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000495522	ENST00000452658	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000495522	ENST00000468094	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000495522	ENST00000474406	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000495522	ENST00000482292	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000495522	ENST00000491095	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000495522	ENST00000547641	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000495522	ENST00000547952	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000495522	ENST00000548040	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000495522	ENST00000552711	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000543443	ENST00000383207	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000543443	ENST00000399383	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000543443	ENST00000399385	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000543443	ENST00000412289	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000543443	ENST00000425878	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000543443	ENST00000431830	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000543443	ENST00000432391	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000543443	ENST00000442285	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000543443	ENST00000445559	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000543443	ENST00000448594	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000543443	ENST00000451970	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000543443	ENST00000452658	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000543443	ENST00000468094	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000543443	ENST00000474406	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000543443	ENST00000482292	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000543443	ENST00000491095	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000543443	ENST00000547641	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000543443	ENST00000547952	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000543443	ENST00000548040	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+
5CDS-intron	ENST00000543443	ENST00000552711	CALD1	chr7	134650137	+	PFDN6	chr6	33257546	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for CALD1-PFDN6

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CALD1	chr7	134650137	+	PFDN6	chr6	33257551	+	0.7848145	0.21518555
CALD1	chr7	134650137	+	PFDN6	chr6	33257551	+	0.7848145	0.21518555

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CALD1-PFDN6

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:134650137/:33257546)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CALD1 Q05682	.
FUNCTION: Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250, ECO:0000269\|PubMed:8227296}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for CALD1-PFDN6

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CALD1-PFDN6

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CALD1-PFDN6

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CALD1-PFDN6

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	CALD1	C0003873	Rheumatoid Arthritis	1	CTD_human
Hgene	CALD1	C0087031	Juvenile-Onset Still Disease	1	CTD_human
Hgene	CALD1	C3495559	Juvenile arthritis	1	CTD_human
Hgene	CALD1	C3714758	Juvenile psoriatic arthritis	1	CTD_human
Hgene	CALD1	C4552091	Polyarthritis, Juvenile, Rheumatoid Factor Negative	1	CTD_human
Hgene	CALD1	C4704862	Polyarthritis, Juvenile, Rheumatoid Factor Positive	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:CALD1-PFDN6 (FusionGDB2 ID:HG800TG10471)

Fusion Gene Summary for CALD1-PFDN6

Fusion Gene ORF analysis for CALD1-PFDN6

Fusion Genomic Features for CALD1-PFDN6

Fusion Protein Features for CALD1-PFDN6

Fusion Gene Sequence for CALD1-PFDN6

Fusion Gene PPI Analysis for CALD1-PFDN6

Related Drugs for CALD1-PFDN6

Related Diseases for CALD1-PFDN6

Fusion Gene Studies
in Kim Lab