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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FHOD3-ESRRB (FusionGDB2 ID:HG80206TG2103)

Fusion Gene Summary for FHOD3-ESRRB

check button Fusion gene summary
Fusion gene informationFusion gene name: FHOD3-ESRRB
Fusion gene ID: hg80206tg2103
HgeneTgene
Gene symbol

FHOD3

ESRRB

Gene ID

80206

2103

Gene nameformin homology 2 domain containing 3estrogen related receptor beta
SynonymsFHOS2|Formactin2DFNB35|ERR beta-2|ERR2|ERRb|ERRbeta2|ESRL2|NR3B2
Cytomap('FHOD3')('ESRRB')

18q12.2

14q24.3

Type of geneprotein-codingprotein-coding
DescriptionFH1/FH2 domain-containing protein 3formactin-2formin homolog overexpressed in spleen 2steroid hormone receptor ERR2estrogen receptor-like 2estrogen-related nuclear receptor betanuclear receptor ERRB2nuclear receptor subfamily 3 group B member 2orphan nuclear receptor
Modification date2020031320200326
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000257209, ENST00000359247, 
ENST00000445677, ENST00000590592, 
ENST00000587493, ENST00000591635, 
ENST00000592128, 
Fusion gene scores* DoF score8 X 6 X 8=3847 X 7 X 4=196
# samples 137
** MAII scorelog2(13/384*10)=-1.5625946876927
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FHOD3 [Title/Abstract] AND ESRRB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFHOD3(33952707)-ESRRB(76948359), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneESRRB

GO:0006355

regulation of transcription, DNA-templated

23836911

TgeneESRRB

GO:0019827

stem cell population maintenance

25522312



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ACCTCGA-OR-A5KY-01AFHOD3chr18

33952707

-ESRRBchr14

76948359

+
ChimerDB4ACCTCGA-OR-A5KY-01AFHOD3chr18

33952707

+ESRRBchr14

76948359

+


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Fusion Gene ORF analysis for FHOD3-ESRRB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000257209ENST00000261532FHOD3chr18

33952707

+ESRRBchr14

76948359

+
5CDS-3UTRENST00000257209ENST00000380887FHOD3chr18

33952707

+ESRRBchr14

76948359

+
5CDS-3UTRENST00000257209ENST00000507951FHOD3chr18

33952707

+ESRRBchr14

76948359

+
5CDS-3UTRENST00000257209ENST00000509242FHOD3chr18

33952707

+ESRRBchr14

76948359

+
5CDS-3UTRENST00000257209ENST00000556177FHOD3chr18

33952707

+ESRRBchr14

76948359

+
5CDS-3UTRENST00000359247ENST00000261532FHOD3chr18

33952707

+ESRRBchr14

76948359

+
5CDS-3UTRENST00000359247ENST00000380887FHOD3chr18

33952707

+ESRRBchr14

76948359

+
5CDS-3UTRENST00000359247ENST00000507951FHOD3chr18

33952707

+ESRRBchr14

76948359

+
5CDS-3UTRENST00000359247ENST00000509242FHOD3chr18

33952707

+ESRRBchr14

76948359

+
5CDS-3UTRENST00000359247ENST00000556177FHOD3chr18

33952707

+ESRRBchr14

76948359

+
5CDS-3UTRENST00000445677ENST00000261532FHOD3chr18

33952707

+ESRRBchr14

76948359

+
5CDS-3UTRENST00000445677ENST00000380887FHOD3chr18

33952707

+ESRRBchr14

76948359

+
5CDS-3UTRENST00000445677ENST00000507951FHOD3chr18

33952707

+ESRRBchr14

76948359

+
5CDS-3UTRENST00000445677ENST00000509242FHOD3chr18

33952707

+ESRRBchr14

76948359

+
5CDS-3UTRENST00000445677ENST00000556177FHOD3chr18

33952707

+ESRRBchr14

76948359

+
5CDS-3UTRENST00000590592ENST00000261532FHOD3chr18

33952707

+ESRRBchr14

76948359

+
5CDS-3UTRENST00000590592ENST00000380887FHOD3chr18

33952707

+ESRRBchr14

76948359

+
5CDS-3UTRENST00000590592ENST00000507951FHOD3chr18

33952707

+ESRRBchr14

76948359

+
5CDS-3UTRENST00000590592ENST00000509242FHOD3chr18

33952707

+ESRRBchr14

76948359

+
5CDS-3UTRENST00000590592ENST00000556177FHOD3chr18

33952707

+ESRRBchr14

76948359

+
intron-3UTRENST00000587493ENST00000261532FHOD3chr18

33952707

+ESRRBchr14

76948359

+
intron-3UTRENST00000587493ENST00000380887FHOD3chr18

33952707

+ESRRBchr14

76948359

+
intron-3UTRENST00000587493ENST00000507951FHOD3chr18

33952707

+ESRRBchr14

76948359

+
intron-3UTRENST00000587493ENST00000509242FHOD3chr18

33952707

+ESRRBchr14

76948359

+
intron-3UTRENST00000587493ENST00000556177FHOD3chr18

33952707

+ESRRBchr14

76948359

+
intron-3UTRENST00000591635ENST00000261532FHOD3chr18

33952707

+ESRRBchr14

76948359

+
intron-3UTRENST00000591635ENST00000380887FHOD3chr18

33952707

+ESRRBchr14

76948359

+
intron-3UTRENST00000591635ENST00000507951FHOD3chr18

33952707

+ESRRBchr14

76948359

+
intron-3UTRENST00000591635ENST00000509242FHOD3chr18

33952707

+ESRRBchr14

76948359

+
intron-3UTRENST00000591635ENST00000556177FHOD3chr18

33952707

+ESRRBchr14

76948359

+
intron-3UTRENST00000592128ENST00000261532FHOD3chr18

33952707

+ESRRBchr14

76948359

+
intron-3UTRENST00000592128ENST00000380887FHOD3chr18

33952707

+ESRRBchr14

76948359

+
intron-3UTRENST00000592128ENST00000507951FHOD3chr18

33952707

+ESRRBchr14

76948359

+
intron-3UTRENST00000592128ENST00000509242FHOD3chr18

33952707

+ESRRBchr14

76948359

+
intron-3UTRENST00000592128ENST00000556177FHOD3chr18

33952707

+ESRRBchr14

76948359

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for FHOD3-ESRRB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FHOD3chr1833952707+ESRRBchr1476948358+2.29E-050.9999771
FHOD3chr1833952707+ESRRBchr1476948358+2.29E-050.9999771


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FHOD3-ESRRB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:33952707/:76948359)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for FHOD3-ESRRB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FHOD3-ESRRB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FHOD3-ESRRB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FHOD3-ESRRB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFHOD3C0007194Hypertrophic Cardiomyopathy1GENOMICS_ENGLAND
HgeneFHOD3C0013146Drug abuse1CTD_human
HgeneFHOD3C0013170Drug habituation1CTD_human
HgeneFHOD3C0013222Drug Use Disorders1CTD_human
HgeneFHOD3C0029231Organic Mental Disorders, Substance-Induced1CTD_human
HgeneFHOD3C0038580Substance Dependence1CTD_human
HgeneFHOD3C0038586Substance Use Disorders1CTD_human
HgeneFHOD3C0236969Substance-Related Disorders1CTD_human
HgeneFHOD3C0740858Substance abuse problem1CTD_human
HgeneFHOD3C1510472Drug Dependence1CTD_human
HgeneFHOD3C4316881Prescription Drug Abuse1CTD_human
TgeneC3711374Nonsyndromic Deafness6CLINGEN
TgeneC1837857DEAFNESS, AUTOSOMAL RECESSIVE 352CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC1384666hearing impairment1GENOMICS_ENGLAND