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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FHOD3-MOCOS (FusionGDB2 ID:HG80206TG55034)

Fusion Gene Summary for FHOD3-MOCOS

check button Fusion gene summary
Fusion gene informationFusion gene name: FHOD3-MOCOS
Fusion gene ID: hg80206tg55034
HgeneTgene
Gene symbol

FHOD3

MOCOS

Gene ID

80206

55034

Gene nameformin homology 2 domain containing 3molybdenum cofactor sulfurase
SynonymsFHOS2|Formactin2HMCS|MCS|MOS
Cytomap('FHOD3')('MOCOS')

18q12.2

18q12.2

Type of geneprotein-codingprotein-coding
DescriptionFH1/FH2 domain-containing protein 3formactin-2formin homolog overexpressed in spleen 2molybdenum cofactor sulfurase
Modification date2020031320200313
UniProtAcc.

Q96EN8

Ensembl transtripts involved in fusion geneENST00000257209, ENST00000359247, 
ENST00000445677, ENST00000590592, 
ENST00000587493, ENST00000591635, 
ENST00000592128, 		ENST00000587493, 
ENST00000591635, ENST00000592128, 
ENST00000257209, ENST00000359247, 
ENST00000445677, ENST00000590592, 
Fusion gene scores* DoF score8 X 6 X 8=3844 X 5 X 5=100
# samples 1310
** MAII scorelog2(13/384*10)=-1.5625946876927
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/100*10)=0
Context

PubMed: FHOD3 [Title/Abstract] AND MOCOS [Title/Abstract] AND fusion [Title/Abstract]

The landscape and therapeutic relevance of cancer-associated transcript fusions (pmid:  25500544)
Most frequent breakpointFHOD3(33952707)-MOCOS(33836931), # samples:3
FHOD3(33877963)-MOCOS(33836931), # samples:3
Anticipated loss of major functional domain due to fusion event.FHOD3-MOCOS seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FHOD3-MOCOS seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FHOD3-MOCOS seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
FHOD3-MOCOS seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
MOCOS-FHOD3 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
MOCOS-FHOD3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FHOD3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across MOCOS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E9-A22G-01AFHOD3chr18

33877963

+MOCOSchr18

33775220

+
ChimerDB4HNSCTCGA-CV-6954-01AFHOD3chr18

33952707

-MOCOSchr18

33836931

+
ChimerDB4HNSCTCGA-CV-6954-01AFHOD3chr18

33952707

+MOCOSchr18

33836931

+
ChimerDB4HNSCTCGA-CV-6954FHOD3chr18

33952707

+MOCOSchr18

33836931

+
ChimerDB4HNSCTCGA-DQ-5630-01AFHOD3chr18

33877963

-MOCOSchr18

33828885

+
ChimerDB4HNSCTCGA-T3-A92M-01AFHOD3chr18

33877963

-MOCOSchr18

33836931

+
ChimerDB4HNSCTCGA-T3-A92M-01AFHOD3chr18

33877963

+MOCOSchr18

33836931

+
ChimerDB4HNSCTCGA-T3-A92MFHOD3chr18

33877963

+MOCOSchr18

33836931

+


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Fusion Gene ORF analysis for FHOD3-MOCOS

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000257209ENST00000588132FHOD3chr18

33952707

+MOCOSchr18

33836931

+
5CDS-3UTRENST00000257209ENST00000588132FHOD3chr18

33877963

+MOCOSchr18

33836931

+
5CDS-3UTRENST00000359247ENST00000588132FHOD3chr18

33952707

+MOCOSchr18

33836931

+
5CDS-3UTRENST00000359247ENST00000588132FHOD3chr18

33877963

+MOCOSchr18

33836931

+
5CDS-3UTRENST00000445677ENST00000588132FHOD3chr18

33952707

+MOCOSchr18

33836931

+
5CDS-3UTRENST00000445677ENST00000588132FHOD3chr18

33877963

+MOCOSchr18

33836931

+
5CDS-3UTRENST00000590592ENST00000588132FHOD3chr18

33952707

+MOCOSchr18

33836931

+
5CDS-3UTRENST00000590592ENST00000588132FHOD3chr18

33877963

+MOCOSchr18

33836931

+
5CDS-intronENST00000257209ENST00000588132FHOD3chr18

33877963

+MOCOSchr18

33775220

+
5CDS-intronENST00000257209ENST00000588132FHOD3chr18

33877963

-MOCOSchr18

33828885

+
5CDS-intronENST00000359247ENST00000588132FHOD3chr18

33877963

+MOCOSchr18

33775220

+
5CDS-intronENST00000359247ENST00000588132FHOD3chr18

33877963

-MOCOSchr18

33828885

+
5CDS-intronENST00000445677ENST00000588132FHOD3chr18

33877963

+MOCOSchr18

33775220

+
5CDS-intronENST00000445677ENST00000588132FHOD3chr18

33877963

-MOCOSchr18

33828885

+
5CDS-intronENST00000590592ENST00000588132FHOD3chr18

33877963

+MOCOSchr18

33775220

+
5CDS-intronENST00000590592ENST00000588132FHOD3chr18

33877963

-MOCOSchr18

33828885

+
Frame-shiftENST00000257209ENST00000261326FHOD3chr18

33877963

+MOCOSchr18

33775220

+
Frame-shiftENST00000257209ENST00000261326FHOD3chr18

33877963

-MOCOSchr18

33828885

+
Frame-shiftENST00000257209ENST00000261326FHOD3chr18

33877963

+MOCOSchr18

33836931

+
Frame-shiftENST00000359247ENST00000261326FHOD3chr18

33877963

+MOCOSchr18

33775220

+
Frame-shiftENST00000359247ENST00000261326FHOD3chr18

33877963

-MOCOSchr18

33828885

+
Frame-shiftENST00000359247ENST00000261326FHOD3chr18

33877963

+MOCOSchr18

33836931

+
Frame-shiftENST00000445677ENST00000261326FHOD3chr18

33877963

+MOCOSchr18

33775220

+
Frame-shiftENST00000445677ENST00000261326FHOD3chr18

33877963

-MOCOSchr18

33828885

+
Frame-shiftENST00000445677ENST00000261326FHOD3chr18

33877963

+MOCOSchr18

33836931

+
Frame-shiftENST00000590592ENST00000261326FHOD3chr18

33877963

+MOCOSchr18

33775220

+
Frame-shiftENST00000590592ENST00000261326FHOD3chr18

33877963

-MOCOSchr18

33828885

+
Frame-shiftENST00000590592ENST00000261326FHOD3chr18

33877963

+MOCOSchr18

33836931

+
In-frameENST00000257209ENST00000261326FHOD3chr18

33952707

+MOCOSchr18

33836931

+
In-frameENST00000359247ENST00000261326FHOD3chr18

33952707

+MOCOSchr18

33836931

+
In-frameENST00000445677ENST00000261326FHOD3chr18

33952707

+MOCOSchr18

33836931

+
In-frameENST00000590592ENST00000261326FHOD3chr18

33952707

+MOCOSchr18

33836931

+
intron-3CDSENST00000587493ENST00000261326FHOD3chr18

33877963

+MOCOSchr18

33775220

+
intron-3CDSENST00000587493ENST00000261326FHOD3chr18

33952707

+MOCOSchr18

33836931

+
intron-3CDSENST00000587493ENST00000261326FHOD3chr18

33877963

-MOCOSchr18

33828885

+
intron-3CDSENST00000587493ENST00000261326FHOD3chr18

33877963

+MOCOSchr18

33836931

+
intron-3CDSENST00000591635ENST00000261326FHOD3chr18

33877963

+MOCOSchr18

33775220

+
intron-3CDSENST00000591635ENST00000261326FHOD3chr18

33952707

+MOCOSchr18

33836931

+
intron-3CDSENST00000591635ENST00000261326FHOD3chr18

33877963

-MOCOSchr18

33828885

+
intron-3CDSENST00000591635ENST00000261326FHOD3chr18

33877963

+MOCOSchr18

33836931

+
intron-3CDSENST00000592128ENST00000261326FHOD3chr18

33877963

+MOCOSchr18

33775220

+
intron-3CDSENST00000592128ENST00000261326FHOD3chr18

33952707

+MOCOSchr18

33836931

+
intron-3CDSENST00000592128ENST00000261326FHOD3chr18

33877963

-MOCOSchr18

33828885

+
intron-3CDSENST00000592128ENST00000261326FHOD3chr18

33877963

+MOCOSchr18

33836931

+
intron-3UTRENST00000587493ENST00000588132FHOD3chr18

33952707

+MOCOSchr18

33836931

+
intron-3UTRENST00000587493ENST00000588132FHOD3chr18

33877963

+MOCOSchr18

33836931

+
intron-3UTRENST00000591635ENST00000588132FHOD3chr18

33952707

+MOCOSchr18

33836931

+
intron-3UTRENST00000591635ENST00000588132FHOD3chr18

33877963

+MOCOSchr18

33836931

+
intron-3UTRENST00000592128ENST00000588132FHOD3chr18

33952707

+MOCOSchr18

33836931

+
intron-3UTRENST00000592128ENST00000588132FHOD3chr18

33877963

+MOCOSchr18

33836931

+
intron-intronENST00000587493ENST00000588132FHOD3chr18

33877963

+MOCOSchr18

33775220

+
intron-intronENST00000587493ENST00000588132FHOD3chr18

33877963

-MOCOSchr18

33828885

+
intron-intronENST00000591635ENST00000588132FHOD3chr18

33877963

+MOCOSchr18

33775220

+
intron-intronENST00000591635ENST00000588132FHOD3chr18

33877963

-MOCOSchr18

33828885

+
intron-intronENST00000592128ENST00000588132FHOD3chr18

33877963

+MOCOSchr18

33775220

+
intron-intronENST00000592128ENST00000588132FHOD3chr18

33877963

-MOCOSchr18

33828885

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000257209FHOD3chr1833952707+ENST00000261326MOCOSchr1833836931+443445926961311
ENST00000445677FHOD3chr1833952707+ENST00000261326MOCOSchr1833836931+44094341936311
ENST00000590592FHOD3chr1833952707+ENST00000261326MOCOSchr1833836931+43123370839279
ENST00000359247FHOD3chr1833952707+ENST00000261326MOCOSchr1833836931+43123370839279

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000257209ENST00000261326FHOD3chr1833952707+MOCOSchr1833836931+0.0010471240.99895287
ENST00000445677ENST00000261326FHOD3chr1833952707+MOCOSchr1833836931+0.0009856250.9990144
ENST00000590592ENST00000261326FHOD3chr1833952707+MOCOSchr1833836931+0.0009235170.9990765
ENST00000359247ENST00000261326FHOD3chr1833952707+MOCOSchr1833836931+0.0009235170.9990765

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Fusion Genomic Features for FHOD3-MOCOS


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FHOD3chr1833877963+MOCOSchr1833836930+4.35E-050.9999565
FHOD3chr1833877963+MOCOSchr1833836930+4.35E-050.9999565
FHOD3chr1833877963+MOCOSchr1833775219+1.71E-050.99998295
FHOD3chr1833952707+MOCOSchr1833836930+7.67E-060.9999924
FHOD3chr1833952707+MOCOSchr1833836930+7.67E-060.9999924
FHOD3chr1833877963+MOCOSchr1833836930+4.35E-050.9999565
FHOD3chr1833877963+MOCOSchr1833836930+4.35E-050.9999565
FHOD3chr1833877963+MOCOSchr1833775219+1.71E-050.99998295
FHOD3chr1833952707+MOCOSchr1833836930+7.67E-060.9999924
FHOD3chr1833952707+MOCOSchr1833836930+7.67E-060.9999924

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FHOD3-MOCOS


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:33952707/chr18:33836931)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MOCOS

Q96EN8

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. In vitro, the C-terminal domain is able to reduce N-hydroxylated prodrugs, such as benzamidoxime. {ECO:0000255|HAMAP-Rule:MF_03050, ECO:0000269|PubMed:16973608}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFHOD3chr18:33952707chr18:33836931ENST00000257209+325448_4801121440.0Coiled coilOntology_term=ECO:0000255
HgeneFHOD3chr18:33952707chr18:33836931ENST00000359247+324448_4801121423.0Coiled coilOntology_term=ECO:0000255
HgeneFHOD3chr18:33952707chr18:33836931ENST00000445677+324448_4801121402.0Coiled coilOntology_term=ECO:0000255
HgeneFHOD3chr18:33952707chr18:33836931ENST00000590592+329448_4801121623.0Coiled coilOntology_term=ECO:0000255
HgeneFHOD3chr18:33952707chr18:33836931ENST00000592128+110448_4800419.0Coiled coilOntology_term=ECO:0000255
HgeneFHOD3chr18:33952707chr18:33836931ENST00000257209+325626_6351121440.0Compositional biasNote=Poly-Ser
HgeneFHOD3chr18:33952707chr18:33836931ENST00000257209+325827_8721121440.0Compositional biasNote=Pro-rich
HgeneFHOD3chr18:33952707chr18:33836931ENST00000257209+325889_8921121440.0Compositional biasNote=Poly-Lys
HgeneFHOD3chr18:33952707chr18:33836931ENST00000359247+324626_6351121423.0Compositional biasNote=Poly-Ser
HgeneFHOD3chr18:33952707chr18:33836931ENST00000359247+324827_8721121423.0Compositional biasNote=Pro-rich
HgeneFHOD3chr18:33952707chr18:33836931ENST00000359247+324889_8921121423.0Compositional biasNote=Poly-Lys
HgeneFHOD3chr18:33952707chr18:33836931ENST00000445677+324626_6351121402.0Compositional biasNote=Poly-Ser
HgeneFHOD3chr18:33952707chr18:33836931ENST00000445677+324827_8721121402.0Compositional biasNote=Pro-rich
HgeneFHOD3chr18:33952707chr18:33836931ENST00000445677+324889_8921121402.0Compositional biasNote=Poly-Lys
HgeneFHOD3chr18:33952707chr18:33836931ENST00000590592+329626_6351121623.0Compositional biasNote=Poly-Ser
HgeneFHOD3chr18:33952707chr18:33836931ENST00000590592+329827_8721121623.0Compositional biasNote=Pro-rich
HgeneFHOD3chr18:33952707chr18:33836931ENST00000590592+329889_8921121623.0Compositional biasNote=Poly-Lys
HgeneFHOD3chr18:33952707chr18:33836931ENST00000592128+110626_6350419.0Compositional biasNote=Poly-Ser
HgeneFHOD3chr18:33952707chr18:33836931ENST00000592128+110827_8720419.0Compositional biasNote=Pro-rich
HgeneFHOD3chr18:33952707chr18:33836931ENST00000592128+110889_8920419.0Compositional biasNote=Poly-Lys
HgeneFHOD3chr18:33952707chr18:33836931ENST00000257209+3251359_13911121440.0DomainDAD
HgeneFHOD3chr18:33952707chr18:33836931ENST00000257209+32518_4111121440.0DomainGBD/FH3
HgeneFHOD3chr18:33952707chr18:33836931ENST00000257209+325827_8581121440.0DomainNote=FH1
HgeneFHOD3chr18:33952707chr18:33836931ENST00000257209+325883_12791121440.0DomainFH2
HgeneFHOD3chr18:33952707chr18:33836931ENST00000359247+3241359_13911121423.0DomainDAD
HgeneFHOD3chr18:33952707chr18:33836931ENST00000359247+32418_4111121423.0DomainGBD/FH3
HgeneFHOD3chr18:33952707chr18:33836931ENST00000359247+324827_8581121423.0DomainNote=FH1
HgeneFHOD3chr18:33952707chr18:33836931ENST00000359247+324883_12791121423.0DomainFH2
HgeneFHOD3chr18:33952707chr18:33836931ENST00000445677+3241359_13911121402.0DomainDAD
HgeneFHOD3chr18:33952707chr18:33836931ENST00000445677+32418_4111121402.0DomainGBD/FH3
HgeneFHOD3chr18:33952707chr18:33836931ENST00000445677+324827_8581121402.0DomainNote=FH1
HgeneFHOD3chr18:33952707chr18:33836931ENST00000445677+324883_12791121402.0DomainFH2
HgeneFHOD3chr18:33952707chr18:33836931ENST00000590592+3291359_13911121623.0DomainDAD
HgeneFHOD3chr18:33952707chr18:33836931ENST00000590592+32918_4111121623.0DomainGBD/FH3
HgeneFHOD3chr18:33952707chr18:33836931ENST00000590592+329827_8581121623.0DomainNote=FH1
HgeneFHOD3chr18:33952707chr18:33836931ENST00000590592+329883_12791121623.0DomainFH2
HgeneFHOD3chr18:33952707chr18:33836931ENST00000592128+1101359_13910419.0DomainDAD
HgeneFHOD3chr18:33952707chr18:33836931ENST00000592128+11018_4110419.0DomainGBD/FH3
HgeneFHOD3chr18:33952707chr18:33836931ENST00000592128+110827_8580419.0DomainNote=FH1
HgeneFHOD3chr18:33952707chr18:33836931ENST00000592128+110883_12790419.0DomainFH2
TgeneMOCOSchr18:33952707chr18:33836931ENST000002613261015706_867721889.0DomainMOSC


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Fusion Gene Sequence for FHOD3-MOCOS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>30394_30394_1_FHOD3-MOCOS_FHOD3_chr18_33952707_ENST00000257209_MOCOS_chr18_33836931_ENST00000261326_length(transcript)=4434nt_BP=459nt
AGCCTGCGAGTCCGCGAGCCAGCGAGCTGCGGCTGCGGCCTCCCCTGCGCGCAGCTACCCGGGCGTCCCGGCCCGCGGCCCCGCTAACCC
CGGGGCCCGCGCCCCCGCGGCAGGGATGCATCATGGCCACGCTGGCTTGCCGGGTGCAGTTCTTGGACGACACGGACCCTTTCAACAGCA
CCAACTTCCCCGAGCCCAGCCGGCCGCCGCTGTTCACGTTCCGCGAGGACCTCGCGCTCGGCACCCAGCTGGCGGGGGTCCATAGGCTGC
TGCAGGCGCCGCACAAGCTGGATGACTGTACTCTGCAGCTCTCTCACAATGGCGCCTACCTGGATTTGGAGGCCACCCTGGCAGAGCAGC
GGGATGAGTTGGAAGGCTTCCAGGATGACGCCGGGCGGGGCAAGAAGCACAGCATCATCCTAAGGACGCAGCTGTCTGTGAGGGTCCATG
CCTGCATCGATCAACTTCCTGGTACAATGGCCACCCTTTCTCTGGTGAATGAGGCACAGTATCTGCTGATCAACACATCCAGTATTTTGG
AACTTCACCGGCAACTAAACACCAGTGATGAGAATGGAAAGGAGGAATTATTCTCACTGAAGGATCTCAGCTTGCGTTTTCGTGCCAATA
TTATTATCAATGGAAAAAGGGCTTTTGAAGAAGAGAAATGGGATGAGATTTCAATTGGCTCTTTGCGTTTCCAGGTTTTGGGGCCTTGTC
ACAGATGCCAGATGATTTGCATCGACCAGCAAACTGGGCAACGAAACCAGCATGTTTTCCAAAAACTTTCTGAGAGTCGTGAAACAAAGG
TGAACTTTGGCATGTACCTGATGCATGCATCATTGGATTTATCCTCCCCATGTTTCCTGTCTGTAGGATCTCAGGTGCTCCCTGTGTTGA
AAGAGAATGTGGAAGGTCATGATTTACCTGCATCTGAGAAACACCAGGATGTTACCTCCTAAAAAAAATTTTTAGCATAAAGTTTCTCTT
TTACAGTGATCTCTATTATTGTTAAGATCTGCAACTTGGTTCAGTAGAACTTGATGTTTTGAATAAGGAGAGCTCTTTTTCTTTAGAGGC
AGGGAATGCTCTCACCTGCTTCCTTCTGCCTTTGACTTCTCACCCTGCAAATTTGCACTGGCTGTGCTCAGGAGAGCACTTCTGAGGCCT
CAGGAACGAATGCTGCACCCACATCCAGTGAGGCTCCTGTAGGTATTTGAAGTATAATCACTTGTAATCAGATGAAATTTTTAATGAAGT
TCACTGGGAAGATTGAACTTACTGCGGGTCCCTATTTTGCCATTTTCTCACATTGTTACTTTGTTTTTAGAGAGCATCTTTGGATCTCTC
CAACCCGTTTGTAGTGAGGAAGGGAGTCTATGCCCAGTGATCCTGGGTATGAGAAGGTGCTCCTCTCCTCCCATGTACATGATGGTGTGG
GTTTATGCTCAGGGGCCCAGAGGGTAACTTGTGACCACATTCCTTGAGGGGAGTTTCTACCAGAATATTTATATTCTGAGCAAAGGCACA
GGCCAGCAATTCCTTTCCTGTTGCTTCCCATCCCTGGCCTCCGTCCTCATCCCCCACTGAGTTGATGCACTGAGGATGGCTCACGAGCCT
GAAGTTACACTCAGTGATGGCTGTGCTTATGCAGGTTGTCATCCTCCCCTCCACAAGCCCACAGGATGGTGTTGGTCCATCACCCGAGAG
CCTCCAAATCCTATCGAGGGAGGAACTTTGGCATTCAGGAATCCTGTCTGTATCATCTTTGACCACTGCTCCTGCAGCCTCCAGATGAAA
ATGTCCAGTGAGGAAATCTCATTCTCTAATGAAGTTACCCATCCCGCTGAGTTTCTAAGAAGTTTCTCCCTGTGCGGAGCTTGTGTGTGC
CTTATCTGCTTCTGCATGACTTCCAGCCTGGGGTCTTACCCTGTCCTCTGGAGCAATGCAGAGTGAGTACATCCACTCCACATTCATTCT
GCTGGCGTCCTTCTGAAGCCTGCTGTCCATGTGTGAACCCAGTCCCTTCATCATCTTCCCCCTGGATGGTTGTATTTTTCCAGTCACTTC
TCCCCCAAATGTCTGCCTGCTGCAGCCCACTGCATCTTTTGAAAGCCTGTGCCACCCCATCTCTCCTGCTGCTCAGTTGGAGAGCAGGCT
CCAGGCTCAGGCTTCCCTAATGTATCTGTTCAGAGCCTGTGGGATTCAGGGTCAGTTTGTTTCATTATCACATTTGTAGGACTTTGTGTT
GTTCCCAGCACTAGGTGAGATTTGAAAGATGAGGTGTGCTCTGTTCTCAAGGATTGTTGAGATGGAGCCTAATGATTGCACACTCACGTG
CTGTGAAGAGTTAAGGGTAAAAAGTACAACTCTGACTCTGGTTCCTGAGATCACCGAAAGAAGAGGCAAATGAAGTTAGGTGGGGTGGGG
TGGGGTTTATTGTTTTGAACTGTTTATTAAAAACGCAACCTCTTCAAAGACTCAGCACTGCCACATCATATGAGTGGACTTGTCCTCATC
AGCTAACTGATAGGAGAACAATGCCCTAAAGTAATGGATTTATCCACCTACTCAGGCCAGTTTCATGCAGGAGGGAACTTTCCAGATGGC
ACATTGCCCCATTTCCAAGACCTTCCGCTGACAAATGCATCATATTAATTATGATGGAAAACAAGTAAGAAGGCATGCTCTACAAAAATT
AGGTCACTTGCCCAGGTGCGGTGGCTCACACCTGTAATTCCAGCACTTTGGGAGGCTGACGTGGGCAGATCATGAGGTCAGGAGATCGAG
ACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAATACAAAAAATTAGCTGGGCATGGTGGCATGCACCTGTAGTCCCAGCTAC
TTGGGAGGCTGAGGCAGGGGAATCGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATCATGCCACTGCACACCGGCCTGGTGAC
AGAGCAAGACTCCATCTCAAAAAAAAAAAAAAAAAAATTAGGTCACTTTTGTCATCAAGAATATGTTTTTCTTATCCACGTCTATGTCAC
CTTTTGCAGTAGATACTTTCATGACTGATTTCAGGCTTTTTGTTTTTTTGAGACAGGGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTG
GCATGATCACAGATCATTGCAGCCTTGACCTCTTGGGCTCAAGCGATTCCCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCACAC
ATCACCACATCCAGCTAATTTTTTTTTTCTTTTTTTTCTTTTTGGTAGAGATGGCATCTCACTTTGTTGCCCAGGCTAGTTTTGAATTCC
TGGGCTCAAGCCATCCTCCCGCCACAGCCTCCCAAAGTTCTGGGATTACAAGTGTGAGCCACTGTGCCCAGCTTTTGATTTCAGACATTT
TAATGCAGATCCTCTCCTTTACAGCACTATTATTTGGTTATCTACTTATAATTACTGATTTAACATTGATCTGTTTTCACTAGACTGTAA
GCTCCATGAGGACAAGTCCTGTGCCAGTATATCTCTAGTGTCAGCAGACAATACTCAAAATTTGTTGACAGACTATTTAAAGCTGCCCCT
ATTTTTATCATTAATTGATTGAATATTAATTAAATATATTTTATTAATTTAAAATGAATTTTAAATGCATTTTTTCTTTAGTGTCTACCT
TCAATATTTCTTGTATGAAGTTTCAGCTAAAAATGTACTTTGTGTATCTGTAGAGTGGCTTCATATTCAGAGTTTATGGACATTTATGAT
TTTATGTCCCCTCCTTGGTTCTTATCTCCTGGAGTTCAGCCTTATGTGCTTCTCAAAGTGTATAACAAAATCAAAGACAATGTCATGTCC
CTTGAATTTAATTCTAACACCAAACCTTGGTGTTAGAGTCACAAAAAGTCCTTTTTTAAAAAAACTTGGTGAGAACAGACAATAACTTGT
CTTTCTGGGCATTCGCGTCATGGTCCTTTTAGCCAGAAGAGAGGTTTTCTTTTGCATAGTTTGGTGAGCATCAAGAATCCTTTAAGGAGG
GTGGCGGTGCTGACTTCTCCCCATTGAGAGTCAGCCTCATCCCCTCCTCAGCCTTGTGGATGGAGAAGAACAGGCAGTGATATACATTTT
CTGCTGTTGAAAGATGTCCGCTTATCCTTCTCTTTCAGTGAAAAGTTGCTTTTTTATTCAATATGTACTGAACAGGTTCTAGAGTTTCAG
AAACAAAAGAAACAGAACCAACATTTATAGATCTCACTATAGAGGCATCACTAATTGGGGAAAGACAGACTAGGTAATAGTCAGATGTGA
TATAGTATGTTTAAGCTATAGGATGGCAGGTGCATGAGTGTTGGTTGTATTATTCTTTATTTTTTTGTATGACTTATGATATTCATGATA
ATTAAAACGTTTTGGAACAATTCA

>30394_30394_1_FHOD3-MOCOS_FHOD3_chr18_33952707_ENST00000257209_MOCOS_chr18_33836931_ENST00000261326_length(amino acids)=311AA_BP=144
MRLRPPLRAATRASRPAAPLTPGPAPPRQGCIMATLACRVQFLDDTDPFNSTNFPEPSRPPLFTFREDLALGTQLAGVHRLLQAPHKLDD
CTLQLSHNGAYLDLEATLAEQRDELEGFQDDAGRGKKHSIILRTQLSVRVHACIDQLPGTMATLSLVNEAQYLLINTSSILELHRQLNTS
DENGKEELFSLKDLSLRFRANIIINGKRAFEEEKWDEISIGSLRFQVLGPCHRCQMICIDQQTGQRNQHVFQKLSESRETKVNFGMYLMH
ASLDLSSPCFLSVGSQVLPVLKENVEGHDLPASEKHQDVTS

--------------------------------------------------------------
>30394_30394_2_FHOD3-MOCOS_FHOD3_chr18_33952707_ENST00000359247_MOCOS_chr18_33836931_ENST00000261326_length(transcript)=4312nt_BP=337nt
ATGGCCACGCTGGCTTGCCGGGTGCAGTTCTTGGACGACACGGACCCTTTCAACAGCACCAACTTCCCCGAGCCCAGCCGGCCGCCGCTG
TTCACGTTCCGCGAGGACCTCGCGCTCGGCACCCAGCTGGCGGGGGTCCATAGGCTGCTGCAGGCGCCGCACAAGCTGGATGACTGTACT
CTGCAGCTCTCTCACAATGGCGCCTACCTGGATTTGGAGGCCACCCTGGCAGAGCAGCGGGATGAGTTGGAAGGCTTCCAGGATGACGCC
GGGCGGGGCAAGAAGCACAGCATCATCCTAAGGACGCAGCTGTCTGTGAGGGTCCATGCCTGCATCGATCAACTTCCTGGTACAATGGCC
ACCCTTTCTCTGGTGAATGAGGCACAGTATCTGCTGATCAACACATCCAGTATTTTGGAACTTCACCGGCAACTAAACACCAGTGATGAG
AATGGAAAGGAGGAATTATTCTCACTGAAGGATCTCAGCTTGCGTTTTCGTGCCAATATTATTATCAATGGAAAAAGGGCTTTTGAAGAA
GAGAAATGGGATGAGATTTCAATTGGCTCTTTGCGTTTCCAGGTTTTGGGGCCTTGTCACAGATGCCAGATGATTTGCATCGACCAGCAA
ACTGGGCAACGAAACCAGCATGTTTTCCAAAAACTTTCTGAGAGTCGTGAAACAAAGGTGAACTTTGGCATGTACCTGATGCATGCATCA
TTGGATTTATCCTCCCCATGTTTCCTGTCTGTAGGATCTCAGGTGCTCCCTGTGTTGAAAGAGAATGTGGAAGGTCATGATTTACCTGCA
TCTGAGAAACACCAGGATGTTACCTCCTAAAAAAAATTTTTAGCATAAAGTTTCTCTTTTACAGTGATCTCTATTATTGTTAAGATCTGC
AACTTGGTTCAGTAGAACTTGATGTTTTGAATAAGGAGAGCTCTTTTTCTTTAGAGGCAGGGAATGCTCTCACCTGCTTCCTTCTGCCTT
TGACTTCTCACCCTGCAAATTTGCACTGGCTGTGCTCAGGAGAGCACTTCTGAGGCCTCAGGAACGAATGCTGCACCCACATCCAGTGAG
GCTCCTGTAGGTATTTGAAGTATAATCACTTGTAATCAGATGAAATTTTTAATGAAGTTCACTGGGAAGATTGAACTTACTGCGGGTCCC
TATTTTGCCATTTTCTCACATTGTTACTTTGTTTTTAGAGAGCATCTTTGGATCTCTCCAACCCGTTTGTAGTGAGGAAGGGAGTCTATG
CCCAGTGATCCTGGGTATGAGAAGGTGCTCCTCTCCTCCCATGTACATGATGGTGTGGGTTTATGCTCAGGGGCCCAGAGGGTAACTTGT
GACCACATTCCTTGAGGGGAGTTTCTACCAGAATATTTATATTCTGAGCAAAGGCACAGGCCAGCAATTCCTTTCCTGTTGCTTCCCATC
CCTGGCCTCCGTCCTCATCCCCCACTGAGTTGATGCACTGAGGATGGCTCACGAGCCTGAAGTTACACTCAGTGATGGCTGTGCTTATGC
AGGTTGTCATCCTCCCCTCCACAAGCCCACAGGATGGTGTTGGTCCATCACCCGAGAGCCTCCAAATCCTATCGAGGGAGGAACTTTGGC
ATTCAGGAATCCTGTCTGTATCATCTTTGACCACTGCTCCTGCAGCCTCCAGATGAAAATGTCCAGTGAGGAAATCTCATTCTCTAATGA
AGTTACCCATCCCGCTGAGTTTCTAAGAAGTTTCTCCCTGTGCGGAGCTTGTGTGTGCCTTATCTGCTTCTGCATGACTTCCAGCCTGGG
GTCTTACCCTGTCCTCTGGAGCAATGCAGAGTGAGTACATCCACTCCACATTCATTCTGCTGGCGTCCTTCTGAAGCCTGCTGTCCATGT
GTGAACCCAGTCCCTTCATCATCTTCCCCCTGGATGGTTGTATTTTTCCAGTCACTTCTCCCCCAAATGTCTGCCTGCTGCAGCCCACTG
CATCTTTTGAAAGCCTGTGCCACCCCATCTCTCCTGCTGCTCAGTTGGAGAGCAGGCTCCAGGCTCAGGCTTCCCTAATGTATCTGTTCA
GAGCCTGTGGGATTCAGGGTCAGTTTGTTTCATTATCACATTTGTAGGACTTTGTGTTGTTCCCAGCACTAGGTGAGATTTGAAAGATGA
GGTGTGCTCTGTTCTCAAGGATTGTTGAGATGGAGCCTAATGATTGCACACTCACGTGCTGTGAAGAGTTAAGGGTAAAAAGTACAACTC
TGACTCTGGTTCCTGAGATCACCGAAAGAAGAGGCAAATGAAGTTAGGTGGGGTGGGGTGGGGTTTATTGTTTTGAACTGTTTATTAAAA
ACGCAACCTCTTCAAAGACTCAGCACTGCCACATCATATGAGTGGACTTGTCCTCATCAGCTAACTGATAGGAGAACAATGCCCTAAAGT
AATGGATTTATCCACCTACTCAGGCCAGTTTCATGCAGGAGGGAACTTTCCAGATGGCACATTGCCCCATTTCCAAGACCTTCCGCTGAC
AAATGCATCATATTAATTATGATGGAAAACAAGTAAGAAGGCATGCTCTACAAAAATTAGGTCACTTGCCCAGGTGCGGTGGCTCACACC
TGTAATTCCAGCACTTTGGGAGGCTGACGTGGGCAGATCATGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCT
CTACTAAAATACAAAAAATTAGCTGGGCATGGTGGCATGCACCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGGGAATCGCTTGAAC
CCGGGAGGCGGAGGTTGCAGTGAGCCGAGATCATGCCACTGCACACCGGCCTGGTGACAGAGCAAGACTCCATCTCAAAAAAAAAAAAAA
AAAAATTAGGTCACTTTTGTCATCAAGAATATGTTTTTCTTATCCACGTCTATGTCACCTTTTGCAGTAGATACTTTCATGACTGATTTC
AGGCTTTTTGTTTTTTTGAGACAGGGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCATGATCACAGATCATTGCAGCCTTGACCTC
TTGGGCTCAAGCGATTCCCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCACACATCACCACATCCAGCTAATTTTTTTTTTCTTT
TTTTTCTTTTTGGTAGAGATGGCATCTCACTTTGTTGCCCAGGCTAGTTTTGAATTCCTGGGCTCAAGCCATCCTCCCGCCACAGCCTCC
CAAAGTTCTGGGATTACAAGTGTGAGCCACTGTGCCCAGCTTTTGATTTCAGACATTTTAATGCAGATCCTCTCCTTTACAGCACTATTA
TTTGGTTATCTACTTATAATTACTGATTTAACATTGATCTGTTTTCACTAGACTGTAAGCTCCATGAGGACAAGTCCTGTGCCAGTATAT
CTCTAGTGTCAGCAGACAATACTCAAAATTTGTTGACAGACTATTTAAAGCTGCCCCTATTTTTATCATTAATTGATTGAATATTAATTA
AATATATTTTATTAATTTAAAATGAATTTTAAATGCATTTTTTCTTTAGTGTCTACCTTCAATATTTCTTGTATGAAGTTTCAGCTAAAA
ATGTACTTTGTGTATCTGTAGAGTGGCTTCATATTCAGAGTTTATGGACATTTATGATTTTATGTCCCCTCCTTGGTTCTTATCTCCTGG
AGTTCAGCCTTATGTGCTTCTCAAAGTGTATAACAAAATCAAAGACAATGTCATGTCCCTTGAATTTAATTCTAACACCAAACCTTGGTG
TTAGAGTCACAAAAAGTCCTTTTTTAAAAAAACTTGGTGAGAACAGACAATAACTTGTCTTTCTGGGCATTCGCGTCATGGTCCTTTTAG
CCAGAAGAGAGGTTTTCTTTTGCATAGTTTGGTGAGCATCAAGAATCCTTTAAGGAGGGTGGCGGTGCTGACTTCTCCCCATTGAGAGTC
AGCCTCATCCCCTCCTCAGCCTTGTGGATGGAGAAGAACAGGCAGTGATATACATTTTCTGCTGTTGAAAGATGTCCGCTTATCCTTCTC
TTTCAGTGAAAAGTTGCTTTTTTATTCAATATGTACTGAACAGGTTCTAGAGTTTCAGAAACAAAAGAAACAGAACCAACATTTATAGAT
CTCACTATAGAGGCATCACTAATTGGGGAAAGACAGACTAGGTAATAGTCAGATGTGATATAGTATGTTTAAGCTATAGGATGGCAGGTG
CATGAGTGTTGGTTGTATTATTCTTTATTTTTTTGTATGACTTATGATATTCATGATAATTAAAACGTTTTGGAACAATTCA

>30394_30394_2_FHOD3-MOCOS_FHOD3_chr18_33952707_ENST00000359247_MOCOS_chr18_33836931_ENST00000261326_length(amino acids)=279AA_BP=112
MATLACRVQFLDDTDPFNSTNFPEPSRPPLFTFREDLALGTQLAGVHRLLQAPHKLDDCTLQLSHNGAYLDLEATLAEQRDELEGFQDDA
GRGKKHSIILRTQLSVRVHACIDQLPGTMATLSLVNEAQYLLINTSSILELHRQLNTSDENGKEELFSLKDLSLRFRANIIINGKRAFEE
EKWDEISIGSLRFQVLGPCHRCQMICIDQQTGQRNQHVFQKLSESRETKVNFGMYLMHASLDLSSPCFLSVGSQVLPVLKENVEGHDLPA
SEKHQDVTS

--------------------------------------------------------------
>30394_30394_3_FHOD3-MOCOS_FHOD3_chr18_33952707_ENST00000445677_MOCOS_chr18_33836931_ENST00000261326_length(transcript)=4409nt_BP=434nt
GCTGCGGCTGCGGCCTCCCCTGCGCGCAGCTACCCGGGCGTCCCGGCCCGCGGCCCCGCTAACCCCGGGGCCCGCGCCCCCGCGGCAGGG
ATGCATCATGGCCACGCTGGCTTGCCGGGTGCAGTTCTTGGACGACACGGACCCTTTCAACAGCACCAACTTCCCCGAGCCCAGCCGGCC
GCCGCTGTTCACGTTCCGCGAGGACCTCGCGCTCGGCACCCAGCTGGCGGGGGTCCATAGGCTGCTGCAGGCGCCGCACAAGCTGGATGA
CTGTACTCTGCAGCTCTCTCACAATGGCGCCTACCTGGATTTGGAGGCCACCCTGGCAGAGCAGCGGGATGAGTTGGAAGGCTTCCAGGA
TGACGCCGGGCGGGGCAAGAAGCACAGCATCATCCTAAGGACGCAGCTGTCTGTGAGGGTCCATGCCTGCATCGATCAACTTCCTGGTAC
AATGGCCACCCTTTCTCTGGTGAATGAGGCACAGTATCTGCTGATCAACACATCCAGTATTTTGGAACTTCACCGGCAACTAAACACCAG
TGATGAGAATGGAAAGGAGGAATTATTCTCACTGAAGGATCTCAGCTTGCGTTTTCGTGCCAATATTATTATCAATGGAAAAAGGGCTTT
TGAAGAAGAGAAATGGGATGAGATTTCAATTGGCTCTTTGCGTTTCCAGGTTTTGGGGCCTTGTCACAGATGCCAGATGATTTGCATCGA
CCAGCAAACTGGGCAACGAAACCAGCATGTTTTCCAAAAACTTTCTGAGAGTCGTGAAACAAAGGTGAACTTTGGCATGTACCTGATGCA
TGCATCATTGGATTTATCCTCCCCATGTTTCCTGTCTGTAGGATCTCAGGTGCTCCCTGTGTTGAAAGAGAATGTGGAAGGTCATGATTT
ACCTGCATCTGAGAAACACCAGGATGTTACCTCCTAAAAAAAATTTTTAGCATAAAGTTTCTCTTTTACAGTGATCTCTATTATTGTTAA
GATCTGCAACTTGGTTCAGTAGAACTTGATGTTTTGAATAAGGAGAGCTCTTTTTCTTTAGAGGCAGGGAATGCTCTCACCTGCTTCCTT
CTGCCTTTGACTTCTCACCCTGCAAATTTGCACTGGCTGTGCTCAGGAGAGCACTTCTGAGGCCTCAGGAACGAATGCTGCACCCACATC
CAGTGAGGCTCCTGTAGGTATTTGAAGTATAATCACTTGTAATCAGATGAAATTTTTAATGAAGTTCACTGGGAAGATTGAACTTACTGC
GGGTCCCTATTTTGCCATTTTCTCACATTGTTACTTTGTTTTTAGAGAGCATCTTTGGATCTCTCCAACCCGTTTGTAGTGAGGAAGGGA
GTCTATGCCCAGTGATCCTGGGTATGAGAAGGTGCTCCTCTCCTCCCATGTACATGATGGTGTGGGTTTATGCTCAGGGGCCCAGAGGGT
AACTTGTGACCACATTCCTTGAGGGGAGTTTCTACCAGAATATTTATATTCTGAGCAAAGGCACAGGCCAGCAATTCCTTTCCTGTTGCT
TCCCATCCCTGGCCTCCGTCCTCATCCCCCACTGAGTTGATGCACTGAGGATGGCTCACGAGCCTGAAGTTACACTCAGTGATGGCTGTG
CTTATGCAGGTTGTCATCCTCCCCTCCACAAGCCCACAGGATGGTGTTGGTCCATCACCCGAGAGCCTCCAAATCCTATCGAGGGAGGAA
CTTTGGCATTCAGGAATCCTGTCTGTATCATCTTTGACCACTGCTCCTGCAGCCTCCAGATGAAAATGTCCAGTGAGGAAATCTCATTCT
CTAATGAAGTTACCCATCCCGCTGAGTTTCTAAGAAGTTTCTCCCTGTGCGGAGCTTGTGTGTGCCTTATCTGCTTCTGCATGACTTCCA
GCCTGGGGTCTTACCCTGTCCTCTGGAGCAATGCAGAGTGAGTACATCCACTCCACATTCATTCTGCTGGCGTCCTTCTGAAGCCTGCTG
TCCATGTGTGAACCCAGTCCCTTCATCATCTTCCCCCTGGATGGTTGTATTTTTCCAGTCACTTCTCCCCCAAATGTCTGCCTGCTGCAG
CCCACTGCATCTTTTGAAAGCCTGTGCCACCCCATCTCTCCTGCTGCTCAGTTGGAGAGCAGGCTCCAGGCTCAGGCTTCCCTAATGTAT
CTGTTCAGAGCCTGTGGGATTCAGGGTCAGTTTGTTTCATTATCACATTTGTAGGACTTTGTGTTGTTCCCAGCACTAGGTGAGATTTGA
AAGATGAGGTGTGCTCTGTTCTCAAGGATTGTTGAGATGGAGCCTAATGATTGCACACTCACGTGCTGTGAAGAGTTAAGGGTAAAAAGT
ACAACTCTGACTCTGGTTCCTGAGATCACCGAAAGAAGAGGCAAATGAAGTTAGGTGGGGTGGGGTGGGGTTTATTGTTTTGAACTGTTT
ATTAAAAACGCAACCTCTTCAAAGACTCAGCACTGCCACATCATATGAGTGGACTTGTCCTCATCAGCTAACTGATAGGAGAACAATGCC
CTAAAGTAATGGATTTATCCACCTACTCAGGCCAGTTTCATGCAGGAGGGAACTTTCCAGATGGCACATTGCCCCATTTCCAAGACCTTC
CGCTGACAAATGCATCATATTAATTATGATGGAAAACAAGTAAGAAGGCATGCTCTACAAAAATTAGGTCACTTGCCCAGGTGCGGTGGC
TCACACCTGTAATTCCAGCACTTTGGGAGGCTGACGTGGGCAGATCATGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAAC
CCCGTCTCTACTAAAATACAAAAAATTAGCTGGGCATGGTGGCATGCACCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGGGAATCG
CTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATCATGCCACTGCACACCGGCCTGGTGACAGAGCAAGACTCCATCTCAAAAAAA
AAAAAAAAAAAATTAGGTCACTTTTGTCATCAAGAATATGTTTTTCTTATCCACGTCTATGTCACCTTTTGCAGTAGATACTTTCATGAC
TGATTTCAGGCTTTTTGTTTTTTTGAGACAGGGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCATGATCACAGATCATTGCAGCCT
TGACCTCTTGGGCTCAAGCGATTCCCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCACACATCACCACATCCAGCTAATTTTTTT
TTTCTTTTTTTTCTTTTTGGTAGAGATGGCATCTCACTTTGTTGCCCAGGCTAGTTTTGAATTCCTGGGCTCAAGCCATCCTCCCGCCAC
AGCCTCCCAAAGTTCTGGGATTACAAGTGTGAGCCACTGTGCCCAGCTTTTGATTTCAGACATTTTAATGCAGATCCTCTCCTTTACAGC
ACTATTATTTGGTTATCTACTTATAATTACTGATTTAACATTGATCTGTTTTCACTAGACTGTAAGCTCCATGAGGACAAGTCCTGTGCC
AGTATATCTCTAGTGTCAGCAGACAATACTCAAAATTTGTTGACAGACTATTTAAAGCTGCCCCTATTTTTATCATTAATTGATTGAATA
TTAATTAAATATATTTTATTAATTTAAAATGAATTTTAAATGCATTTTTTCTTTAGTGTCTACCTTCAATATTTCTTGTATGAAGTTTCA
GCTAAAAATGTACTTTGTGTATCTGTAGAGTGGCTTCATATTCAGAGTTTATGGACATTTATGATTTTATGTCCCCTCCTTGGTTCTTAT
CTCCTGGAGTTCAGCCTTATGTGCTTCTCAAAGTGTATAACAAAATCAAAGACAATGTCATGTCCCTTGAATTTAATTCTAACACCAAAC
CTTGGTGTTAGAGTCACAAAAAGTCCTTTTTTAAAAAAACTTGGTGAGAACAGACAATAACTTGTCTTTCTGGGCATTCGCGTCATGGTC
CTTTTAGCCAGAAGAGAGGTTTTCTTTTGCATAGTTTGGTGAGCATCAAGAATCCTTTAAGGAGGGTGGCGGTGCTGACTTCTCCCCATT
GAGAGTCAGCCTCATCCCCTCCTCAGCCTTGTGGATGGAGAAGAACAGGCAGTGATATACATTTTCTGCTGTTGAAAGATGTCCGCTTAT
CCTTCTCTTTCAGTGAAAAGTTGCTTTTTTATTCAATATGTACTGAACAGGTTCTAGAGTTTCAGAAACAAAAGAAACAGAACCAACATT
TATAGATCTCACTATAGAGGCATCACTAATTGGGGAAAGACAGACTAGGTAATAGTCAGATGTGATATAGTATGTTTAAGCTATAGGATG
GCAGGTGCATGAGTGTTGGTTGTATTATTCTTTATTTTTTTGTATGACTTATGATATTCATGATAATTAAAACGTTTTGGAACAATTCA

>30394_30394_3_FHOD3-MOCOS_FHOD3_chr18_33952707_ENST00000445677_MOCOS_chr18_33836931_ENST00000261326_length(amino acids)=311AA_BP=144
LRLRPPLRAATRASRPAAPLTPGPAPPRQGCIMATLACRVQFLDDTDPFNSTNFPEPSRPPLFTFREDLALGTQLAGVHRLLQAPHKLDD
CTLQLSHNGAYLDLEATLAEQRDELEGFQDDAGRGKKHSIILRTQLSVRVHACIDQLPGTMATLSLVNEAQYLLINTSSILELHRQLNTS
DENGKEELFSLKDLSLRFRANIIINGKRAFEEEKWDEISIGSLRFQVLGPCHRCQMICIDQQTGQRNQHVFQKLSESRETKVNFGMYLMH
ASLDLSSPCFLSVGSQVLPVLKENVEGHDLPASEKHQDVTS

--------------------------------------------------------------
>30394_30394_4_FHOD3-MOCOS_FHOD3_chr18_33952707_ENST00000590592_MOCOS_chr18_33836931_ENST00000261326_length(transcript)=4312nt_BP=337nt
ATGGCCACGCTGGCTTGCCGGGTGCAGTTCTTGGACGACACGGACCCTTTCAACAGCACCAACTTCCCCGAGCCCAGCCGGCCGCCGCTG
TTCACGTTCCGCGAGGACCTCGCGCTCGGCACCCAGCTGGCGGGGGTCCATAGGCTGCTGCAGGCGCCGCACAAGCTGGATGACTGTACT
CTGCAGCTCTCTCACAATGGCGCCTACCTGGATTTGGAGGCCACCCTGGCAGAGCAGCGGGATGAGTTGGAAGGCTTCCAGGATGACGCC
GGGCGGGGCAAGAAGCACAGCATCATCCTAAGGACGCAGCTGTCTGTGAGGGTCCATGCCTGCATCGATCAACTTCCTGGTACAATGGCC
ACCCTTTCTCTGGTGAATGAGGCACAGTATCTGCTGATCAACACATCCAGTATTTTGGAACTTCACCGGCAACTAAACACCAGTGATGAG
AATGGAAAGGAGGAATTATTCTCACTGAAGGATCTCAGCTTGCGTTTTCGTGCCAATATTATTATCAATGGAAAAAGGGCTTTTGAAGAA
GAGAAATGGGATGAGATTTCAATTGGCTCTTTGCGTTTCCAGGTTTTGGGGCCTTGTCACAGATGCCAGATGATTTGCATCGACCAGCAA
ACTGGGCAACGAAACCAGCATGTTTTCCAAAAACTTTCTGAGAGTCGTGAAACAAAGGTGAACTTTGGCATGTACCTGATGCATGCATCA
TTGGATTTATCCTCCCCATGTTTCCTGTCTGTAGGATCTCAGGTGCTCCCTGTGTTGAAAGAGAATGTGGAAGGTCATGATTTACCTGCA
TCTGAGAAACACCAGGATGTTACCTCCTAAAAAAAATTTTTAGCATAAAGTTTCTCTTTTACAGTGATCTCTATTATTGTTAAGATCTGC
AACTTGGTTCAGTAGAACTTGATGTTTTGAATAAGGAGAGCTCTTTTTCTTTAGAGGCAGGGAATGCTCTCACCTGCTTCCTTCTGCCTT
TGACTTCTCACCCTGCAAATTTGCACTGGCTGTGCTCAGGAGAGCACTTCTGAGGCCTCAGGAACGAATGCTGCACCCACATCCAGTGAG
GCTCCTGTAGGTATTTGAAGTATAATCACTTGTAATCAGATGAAATTTTTAATGAAGTTCACTGGGAAGATTGAACTTACTGCGGGTCCC
TATTTTGCCATTTTCTCACATTGTTACTTTGTTTTTAGAGAGCATCTTTGGATCTCTCCAACCCGTTTGTAGTGAGGAAGGGAGTCTATG
CCCAGTGATCCTGGGTATGAGAAGGTGCTCCTCTCCTCCCATGTACATGATGGTGTGGGTTTATGCTCAGGGGCCCAGAGGGTAACTTGT
GACCACATTCCTTGAGGGGAGTTTCTACCAGAATATTTATATTCTGAGCAAAGGCACAGGCCAGCAATTCCTTTCCTGTTGCTTCCCATC
CCTGGCCTCCGTCCTCATCCCCCACTGAGTTGATGCACTGAGGATGGCTCACGAGCCTGAAGTTACACTCAGTGATGGCTGTGCTTATGC
AGGTTGTCATCCTCCCCTCCACAAGCCCACAGGATGGTGTTGGTCCATCACCCGAGAGCCTCCAAATCCTATCGAGGGAGGAACTTTGGC
ATTCAGGAATCCTGTCTGTATCATCTTTGACCACTGCTCCTGCAGCCTCCAGATGAAAATGTCCAGTGAGGAAATCTCATTCTCTAATGA
AGTTACCCATCCCGCTGAGTTTCTAAGAAGTTTCTCCCTGTGCGGAGCTTGTGTGTGCCTTATCTGCTTCTGCATGACTTCCAGCCTGGG
GTCTTACCCTGTCCTCTGGAGCAATGCAGAGTGAGTACATCCACTCCACATTCATTCTGCTGGCGTCCTTCTGAAGCCTGCTGTCCATGT
GTGAACCCAGTCCCTTCATCATCTTCCCCCTGGATGGTTGTATTTTTCCAGTCACTTCTCCCCCAAATGTCTGCCTGCTGCAGCCCACTG
CATCTTTTGAAAGCCTGTGCCACCCCATCTCTCCTGCTGCTCAGTTGGAGAGCAGGCTCCAGGCTCAGGCTTCCCTAATGTATCTGTTCA
GAGCCTGTGGGATTCAGGGTCAGTTTGTTTCATTATCACATTTGTAGGACTTTGTGTTGTTCCCAGCACTAGGTGAGATTTGAAAGATGA
GGTGTGCTCTGTTCTCAAGGATTGTTGAGATGGAGCCTAATGATTGCACACTCACGTGCTGTGAAGAGTTAAGGGTAAAAAGTACAACTC
TGACTCTGGTTCCTGAGATCACCGAAAGAAGAGGCAAATGAAGTTAGGTGGGGTGGGGTGGGGTTTATTGTTTTGAACTGTTTATTAAAA
ACGCAACCTCTTCAAAGACTCAGCACTGCCACATCATATGAGTGGACTTGTCCTCATCAGCTAACTGATAGGAGAACAATGCCCTAAAGT
AATGGATTTATCCACCTACTCAGGCCAGTTTCATGCAGGAGGGAACTTTCCAGATGGCACATTGCCCCATTTCCAAGACCTTCCGCTGAC
AAATGCATCATATTAATTATGATGGAAAACAAGTAAGAAGGCATGCTCTACAAAAATTAGGTCACTTGCCCAGGTGCGGTGGCTCACACC
TGTAATTCCAGCACTTTGGGAGGCTGACGTGGGCAGATCATGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCT
CTACTAAAATACAAAAAATTAGCTGGGCATGGTGGCATGCACCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGGGAATCGCTTGAAC
CCGGGAGGCGGAGGTTGCAGTGAGCCGAGATCATGCCACTGCACACCGGCCTGGTGACAGAGCAAGACTCCATCTCAAAAAAAAAAAAAA
AAAAATTAGGTCACTTTTGTCATCAAGAATATGTTTTTCTTATCCACGTCTATGTCACCTTTTGCAGTAGATACTTTCATGACTGATTTC
AGGCTTTTTGTTTTTTTGAGACAGGGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCATGATCACAGATCATTGCAGCCTTGACCTC
TTGGGCTCAAGCGATTCCCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCACACATCACCACATCCAGCTAATTTTTTTTTTCTTT
TTTTTCTTTTTGGTAGAGATGGCATCTCACTTTGTTGCCCAGGCTAGTTTTGAATTCCTGGGCTCAAGCCATCCTCCCGCCACAGCCTCC
CAAAGTTCTGGGATTACAAGTGTGAGCCACTGTGCCCAGCTTTTGATTTCAGACATTTTAATGCAGATCCTCTCCTTTACAGCACTATTA
TTTGGTTATCTACTTATAATTACTGATTTAACATTGATCTGTTTTCACTAGACTGTAAGCTCCATGAGGACAAGTCCTGTGCCAGTATAT
CTCTAGTGTCAGCAGACAATACTCAAAATTTGTTGACAGACTATTTAAAGCTGCCCCTATTTTTATCATTAATTGATTGAATATTAATTA
AATATATTTTATTAATTTAAAATGAATTTTAAATGCATTTTTTCTTTAGTGTCTACCTTCAATATTTCTTGTATGAAGTTTCAGCTAAAA
ATGTACTTTGTGTATCTGTAGAGTGGCTTCATATTCAGAGTTTATGGACATTTATGATTTTATGTCCCCTCCTTGGTTCTTATCTCCTGG
AGTTCAGCCTTATGTGCTTCTCAAAGTGTATAACAAAATCAAAGACAATGTCATGTCCCTTGAATTTAATTCTAACACCAAACCTTGGTG
TTAGAGTCACAAAAAGTCCTTTTTTAAAAAAACTTGGTGAGAACAGACAATAACTTGTCTTTCTGGGCATTCGCGTCATGGTCCTTTTAG
CCAGAAGAGAGGTTTTCTTTTGCATAGTTTGGTGAGCATCAAGAATCCTTTAAGGAGGGTGGCGGTGCTGACTTCTCCCCATTGAGAGTC
AGCCTCATCCCCTCCTCAGCCTTGTGGATGGAGAAGAACAGGCAGTGATATACATTTTCTGCTGTTGAAAGATGTCCGCTTATCCTTCTC
TTTCAGTGAAAAGTTGCTTTTTTATTCAATATGTACTGAACAGGTTCTAGAGTTTCAGAAACAAAAGAAACAGAACCAACATTTATAGAT
CTCACTATAGAGGCATCACTAATTGGGGAAAGACAGACTAGGTAATAGTCAGATGTGATATAGTATGTTTAAGCTATAGGATGGCAGGTG
CATGAGTGTTGGTTGTATTATTCTTTATTTTTTTGTATGACTTATGATATTCATGATAATTAAAACGTTTTGGAACAATTCA

>30394_30394_4_FHOD3-MOCOS_FHOD3_chr18_33952707_ENST00000590592_MOCOS_chr18_33836931_ENST00000261326_length(amino acids)=279AA_BP=112
MATLACRVQFLDDTDPFNSTNFPEPSRPPLFTFREDLALGTQLAGVHRLLQAPHKLDDCTLQLSHNGAYLDLEATLAEQRDELEGFQDDA
GRGKKHSIILRTQLSVRVHACIDQLPGTMATLSLVNEAQYLLINTSSILELHRQLNTSDENGKEELFSLKDLSLRFRANIIINGKRAFEE
EKWDEISIGSLRFQVLGPCHRCQMICIDQQTGQRNQHVFQKLSESRETKVNFGMYLMHASLDLSSPCFLSVGSQVLPVLKENVEGHDLPA
SEKHQDVTS

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Fusion Gene PPI Analysis for FHOD3-MOCOS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FHOD3-MOCOS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneMOCOSQ96EN8DB00114Pyridoxal phosphateCofactorSmall moleculeApproved|Investigational|Nutraceutical

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Related Diseases for FHOD3-MOCOS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFHOD3C0007194Hypertrophic Cardiomyopathy1GENOMICS_ENGLAND
HgeneFHOD3C0013146Drug abuse1CTD_human
HgeneFHOD3C0013170Drug habituation1CTD_human
HgeneFHOD3C0013222Drug Use Disorders1CTD_human
HgeneFHOD3C0029231Organic Mental Disorders, Substance-Induced1CTD_human
HgeneFHOD3C0038580Substance Dependence1CTD_human
HgeneFHOD3C0038586Substance Use Disorders1CTD_human
HgeneFHOD3C0236969Substance-Related Disorders1CTD_human
HgeneFHOD3C0740858Substance abuse problem1CTD_human
HgeneFHOD3C1510472Drug Dependence1CTD_human
HgeneFHOD3C4316881Prescription Drug Abuse1CTD_human
TgeneC1863688Xanthinuria, Type II4CTD_human;ORPHANET;UNIPROT
TgeneC0013221Drug toxicity1CTD_human
TgeneC0030312Pancytopenia1CTD_human
TgeneC0041755Adverse reaction to drug1CTD_human
TgeneC0042384Vasculitis1CTD_human