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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:FXR1-NAALADL2 (FusionGDB2 ID:HG8087TG254827) |
Fusion Gene Summary for FXR1-NAALADL2 |
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Fusion gene information | Fusion gene name: FXR1-NAALADL2 | Fusion gene ID: hg8087tg254827 | Hgene | Tgene | Gene symbol | FXR1 | NAALADL2 | Gene ID | 8087 | 254827 |
Gene name | FMR1 autosomal homolog 1 | N-acetylated alpha-linked acidic dipeptidase like 2 | |
Synonyms | FXR1P | - | |
Cytomap | ('FXR1')('NAALADL2') 3q26.33 | 3q26.31 | |
Type of gene | protein-coding | protein-coding | |
Description | fragile X mental retardation syndrome-related protein 1fragile X mental retardation, autosomal homolog 1 | inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2N-acetylated alpha-linked acidic dipeptidase 2NAALADase L2glutamate carboxypeptidase II-type non-peptidase homologue | |
Modification date | 20200320 | 20200313 | |
UniProtAcc | P51114 | Q58DX5 | |
Ensembl transtripts involved in fusion gene | ENST00000357559, ENST00000445140, ENST00000480918, ENST00000305586, ENST00000468861, ENST00000491062, ENST00000491674, | ||
Fusion gene scores | * DoF score | 17 X 9 X 7=1071 | 21 X 16 X 9=3024 |
# samples | 20 | 24 | |
** MAII score | log2(20/1071*10)=-2.42088657497553 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(24/3024*10)=-3.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: FXR1 [Title/Abstract] AND NAALADL2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | FXR1(180653019)-NAALADL2(175165017), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. | FXR1-NAALADL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | FXR1 | GO:2000637 | positive regulation of gene silencing by miRNA | 17057366 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | CESC | TCGA-C5-A1ML-01A | FXR1 | chr3 | 180653019 | - | NAALADL2 | chr3 | 175165017 | + |
ChimerDB4 | CESC | TCGA-C5-A1ML-01A | FXR1 | chr3 | 180653019 | + | NAALADL2 | chr3 | 175165017 | + |
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Fusion Gene ORF analysis for FXR1-NAALADL2 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000357559 | ENST00000473253 | FXR1 | chr3 | 180653019 | + | NAALADL2 | chr3 | 175165017 | + |
5CDS-3UTR | ENST00000445140 | ENST00000473253 | FXR1 | chr3 | 180653019 | + | NAALADL2 | chr3 | 175165017 | + |
5CDS-3UTR | ENST00000480918 | ENST00000473253 | FXR1 | chr3 | 180653019 | + | NAALADL2 | chr3 | 175165017 | + |
5UTR-3CDS | ENST00000305586 | ENST00000454872 | FXR1 | chr3 | 180653019 | + | NAALADL2 | chr3 | 175165017 | + |
5UTR-3CDS | ENST00000468861 | ENST00000454872 | FXR1 | chr3 | 180653019 | + | NAALADL2 | chr3 | 175165017 | + |
5UTR-3UTR | ENST00000305586 | ENST00000473253 | FXR1 | chr3 | 180653019 | + | NAALADL2 | chr3 | 175165017 | + |
5UTR-3UTR | ENST00000468861 | ENST00000473253 | FXR1 | chr3 | 180653019 | + | NAALADL2 | chr3 | 175165017 | + |
Frame-shift | ENST00000357559 | ENST00000454872 | FXR1 | chr3 | 180653019 | + | NAALADL2 | chr3 | 175165017 | + |
Frame-shift | ENST00000445140 | ENST00000454872 | FXR1 | chr3 | 180653019 | + | NAALADL2 | chr3 | 175165017 | + |
Frame-shift | ENST00000480918 | ENST00000454872 | FXR1 | chr3 | 180653019 | + | NAALADL2 | chr3 | 175165017 | + |
intron-3CDS | ENST00000491062 | ENST00000454872 | FXR1 | chr3 | 180653019 | + | NAALADL2 | chr3 | 175165017 | + |
intron-3CDS | ENST00000491674 | ENST00000454872 | FXR1 | chr3 | 180653019 | + | NAALADL2 | chr3 | 175165017 | + |
intron-3UTR | ENST00000491062 | ENST00000473253 | FXR1 | chr3 | 180653019 | + | NAALADL2 | chr3 | 175165017 | + |
intron-3UTR | ENST00000491674 | ENST00000473253 | FXR1 | chr3 | 180653019 | + | NAALADL2 | chr3 | 175165017 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for FXR1-NAALADL2 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
FXR1 | chr3 | 180653019 | + | NAALADL2 | chr3 | 175165016 | + | 1.08E-06 | 0.9999989 |
FXR1 | chr3 | 180653019 | + | NAALADL2 | chr3 | 175165016 | + | 1.08E-06 | 0.9999989 |
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Fusion Protein Features for FXR1-NAALADL2 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:180653019/:175165017) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
FXR1 | NAALADL2 |
FUNCTION: RNA-binding protein required for embryonic and postnatal development of muscle tissue (PubMed:30770808). May regulate intracellular transport and local translation of certain mRNAs (By similarity). {ECO:0000250|UniProtKB:Q61584, ECO:0000269|PubMed:30770808}. | FUNCTION: May be catalytically inactive. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for FXR1-NAALADL2 |
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Fusion Gene PPI Analysis for FXR1-NAALADL2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for FXR1-NAALADL2 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for FXR1-NAALADL2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |