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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Diseases

Fusion gene:CALR-BRD2 (FusionGDB2 ID:HG811TG6046)

Fusion Gene Summary for CALR-BRD2

check button Fusion gene summary
Fusion gene informationFusion gene name: CALR-BRD2
Fusion gene ID: hg811tg6046
HgeneTgene
Gene symbol

CALR

BRD2

Gene ID

811

6046

Gene namecalreticulinbromodomain containing 2
SynonymsCRT|HEL-S-99n|RO|SSA|cC1qRBRD2-IT1|D6S113E|FSH|FSRG1|NAT|O27.1.1|RING3|RNF3
Cytomap('CALR')('BRD2')

19p13.13

6p21.32

Type of geneprotein-codingprotein-coding
DescriptioncalreticulinCRP55ERp60HACBPSicca syndrome antigen A (autoantigen Ro; calreticulin)calregulinendoplasmic reticulum resident protein 60epididymis secretory sperm binding protein Li 99ngrp60bromodomain-containing protein 2BRD2 intronic transcript 1female sterile homeotic-related gene 1really interesting new gene 3 protein
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000316448, 
Fusion gene scores* DoF score18 X 17 X 9=275410 X 15 X 3=450
# samples 2416
** MAII scorelog2(24/2754*10)=-3.52042224852645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/450*10)=-1.49185309632967
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CALR [Title/Abstract] AND BRD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCALR(13055304)-BRD2(32944339), # samples:1
Anticipated loss of major functional domain due to fusion event.CALR-BRD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CALR-BRD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CALR-BRD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CALR-BRD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCALR

GO:0000122

negative regulation of transcription by RNA polymerase II

8107809

HgeneCALR

GO:0006611

protein export from nucleus

11149926

HgeneCALR

GO:0017148

negative regulation of translation

14726956

HgeneCALR

GO:0033144

negative regulation of intracellular steroid hormone receptor signaling pathway

8107809

HgeneCALR

GO:0034504

protein localization to nucleus

15998798

HgeneCALR

GO:0045665

negative regulation of neuron differentiation

8107809

HgeneCALR

GO:0045892

negative regulation of transcription, DNA-templated

8107809

HgeneCALR

GO:0048387

negative regulation of retinoic acid receptor signaling pathway

8107809

TgeneBRD2

GO:0006357

regulation of transcription by RNA polymerase II

18406326


check buttonFusion gene breakpoints across CALR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across BRD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-KK-A6E5-01ACALRchr19

13055304

-BRD2chr6

32944339

+


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Fusion Gene ORF analysis for CALR-BRD2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000316448ENST00000374831CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000383108CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000395287CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000395289CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000399527CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000399528CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000399529CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000414731CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000425201CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000436979CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000438194CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000442219CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000442863CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000443797CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000448067CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000449085CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000449118CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000450320CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000466208CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000466744CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000479973CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000482105CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000488549CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000496118CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000498329CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000546777CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000547286CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000547895CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000548837CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000549126CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000549236CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000549843CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000550142CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000550598CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000552513CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000552587CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000553146CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000580234CALRchr19

13055304

-BRD2chr6

32944339

+
In-frameENST00000316448ENST00000374825CALRchr19

13055304

-BRD2chr6

32944339

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000316448CALRchr1913055304-ENST00000374825BRD2chr632944339+4271190318943483529

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000316448ENST00000374825CALRchr1913055304-BRD2chr632944339+0.0054367320.9945633

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Fusion Genomic Features for CALR-BRD2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CALR-BRD2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:13055304/chr6:32944339)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCALRchr19:13055304chr6:32944339ENST00000316448-99351_408610418.0Compositional biasNote=Asp/Glu/Lys-rich
HgeneCALRchr19:13055304chr6:32944339ENST00000316448-99414_417610418.0MotifNote=Prevents secretion from ER
HgeneCALRchr19:13055304chr6:32944339ENST00000316448-9918_197610418.0RegionNote=N-domain
HgeneCALRchr19:13055304chr6:32944339ENST00000316448-99191_255610418.0RegionNote=4 X approximate repeats
HgeneCALRchr19:13055304chr6:32944339ENST00000316448-99198_308610418.0RegionNote=P-domain
HgeneCALRchr19:13055304chr6:32944339ENST00000316448-99259_297610418.0RegionNote=3 X approximate repeats
HgeneCALRchr19:13055304chr6:32944339ENST00000316448-99309_417610418.0RegionNote=C-domain
HgeneCALRchr19:13055304chr6:32944339ENST00000316448-99191_202610418.0RepeatNote=1-1
HgeneCALRchr19:13055304chr6:32944339ENST00000316448-99210_221610418.0RepeatNote=1-2
HgeneCALRchr19:13055304chr6:32944339ENST00000316448-99227_238610418.0RepeatNote=1-3
HgeneCALRchr19:13055304chr6:32944339ENST00000316448-99244_255610418.0RepeatNote=1-4
HgeneCALRchr19:13055304chr6:32944339ENST00000316448-99259_269610418.0RepeatNote=2-1
HgeneCALRchr19:13055304chr6:32944339ENST00000316448-99273_283610418.0RepeatNote=2-2
HgeneCALRchr19:13055304chr6:32944339ENST00000316448-99287_297610418.0RepeatNote=2-3
TgeneBRD2chr19:13055304chr6:32944339ENST00000374825513476_515275802.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000374825513492_506275802.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000374825513544_566275802.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000374825513551_559275802.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST00000374825513775_793275802.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000374825513775_801275802.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000374831513476_515275802.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000374831513492_506275802.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000374831513544_566275802.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000374831513551_559275802.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST00000374831513775_793275802.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000374831513775_801275802.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000383108013476_5150802.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000383108013492_5060802.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000383108013544_5660802.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000383108013551_5590802.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST0000038310801361_640802.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST00000383108013775_7930802.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000383108013775_8010802.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000395287413476_515275837.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000395287413492_506275837.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000395287413544_566275837.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000395287413551_559275837.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST00000395287413775_793275837.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000395287413775_801275837.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000395289514476_515275837.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000395289514492_506275837.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000395289514544_566275837.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000395289514551_559275837.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST00000395289514775_793275837.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000395289514775_801275837.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000399527013476_5150837.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000399527013492_5060837.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000399527013544_5660837.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000399527013551_5590837.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST0000039952701361_640837.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST00000399527013775_7930837.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000399527013775_8010837.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000399528013476_5150802.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000399528013492_5060802.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000399528013544_5660802.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000399528013551_5590802.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST0000039952801361_640802.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST00000399528013775_7930802.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000399528013775_8010802.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000399529013476_5150802.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000399529013492_5060802.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000399529013544_5660802.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000399529013551_5590802.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST0000039952901361_640802.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST00000399529013775_7930802.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000399529013775_8010802.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000414731013476_5150802.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000414731013492_5060802.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000414731013544_5660802.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000414731013551_5590802.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST0000041473101361_640802.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST00000414731013775_7930802.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000414731013775_8010802.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000436979012476_5150755.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000436979012492_5060755.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000436979012544_5660755.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000436979012551_5590755.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST0000043697901261_640755.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST00000436979012775_7930755.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000436979012775_8010755.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000438194013476_5150802.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000438194013492_5060802.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000438194013544_5660802.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000438194013551_5590802.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST0000043819401361_640802.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST00000438194013775_7930802.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000438194013775_8010802.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000442863013476_5150837.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000442863013492_5060837.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000442863013544_5660837.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000442863013551_5590837.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST0000044286301361_640837.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST00000442863013775_7930837.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000442863013775_8010837.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000448067013476_5150837.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000448067013492_5060837.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000448067013544_5660837.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000448067013551_5590837.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST0000044806701361_640837.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST00000448067013775_7930837.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000448067013775_8010837.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000449085412476_515228755.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000449085412492_506228755.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000449085412544_566228755.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000449085412551_559228755.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST00000449085412775_793228755.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000449085412775_801228755.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000449118013476_5150802.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000449118013492_5060802.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000449118013544_5660802.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000449118013551_5590802.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST0000044911801361_640802.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST00000449118013775_7930802.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000449118013775_8010802.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000547286012476_5150755.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000547286012492_5060755.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000547286012544_5660755.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000547286012551_5590755.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST0000054728601261_640755.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST00000547286012775_7930755.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000547286012775_8010755.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000547895014476_5150837.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000547895014492_5060837.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000547895014544_5660837.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000547895014551_5590837.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST0000054789501461_640837.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST00000547895014775_7930837.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000547895014775_8010837.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000549126015476_5150837.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000549126015492_5060837.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000549126015544_5660837.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000549126015551_5590837.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST0000054912601561_640837.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST00000549126015775_7930837.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000549126015775_8010837.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000549236012476_5150755.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000549236012492_5060755.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000549236012544_5660755.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000549236012551_5590755.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST0000054923601261_640755.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST00000549236012775_7930755.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000549236012775_8010755.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000550142014476_5150837.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000550142014492_5060837.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000550142014544_5660837.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000550142014551_5590837.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST0000055014201461_640837.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST00000550142014775_7930837.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000550142014775_8010837.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000552513012476_5150755.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000552513012492_5060755.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000552513012544_5660755.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000552513012551_5590755.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST0000055251301261_640755.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST00000552513012775_7930755.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000552513012775_8010755.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000552587014476_5150802.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000552587014492_5060802.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000552587014544_5660802.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000552587014551_5590802.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST0000055258701461_640802.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST00000552587014775_7930802.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000552587014775_8010802.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000374825513364_436275802.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000374825513632_714275802.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST00000374831513364_436275802.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000374831513632_714275802.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST00000383108013364_4360802.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000383108013632_7140802.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST0000038310801391_1630802.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST00000395287413364_436275837.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000395287413632_714275837.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST00000395289514364_436275837.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000395289514632_714275837.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST00000399527013364_4360837.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000399527013632_7140837.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST0000039952701391_1630837.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST00000399528013364_4360802.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000399528013632_7140802.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST0000039952801391_1630802.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST00000399529013364_4360802.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000399529013632_7140802.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST0000039952901391_1630802.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST00000414731013364_4360802.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000414731013632_7140802.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST0000041473101391_1630802.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST00000436979012364_4360755.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000436979012632_7140755.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST0000043697901291_1630755.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST00000438194013364_4360802.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000438194013632_7140802.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST0000043819401391_1630802.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST00000442863013364_4360837.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000442863013632_7140837.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST0000044286301391_1630837.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST00000448067013364_4360837.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000448067013632_7140837.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST0000044806701391_1630837.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST00000449085412364_436228755.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000449085412632_714228755.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST00000449118013364_4360802.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000449118013632_7140802.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST0000044911801391_1630802.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST00000547286012364_4360755.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000547286012632_7140755.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST0000054728601291_1630755.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST00000547895014364_4360837.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000547895014632_7140837.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST0000054789501491_1630837.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST00000549126015364_4360837.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000549126015632_7140837.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST0000054912601591_1630837.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST00000549236012364_4360755.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000549236012632_7140755.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST0000054923601291_1630755.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST00000550142014364_4360837.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000550142014632_7140837.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST0000055014201491_1630837.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST00000552513012364_4360755.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000552513012632_7140755.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST0000055251301291_1630755.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST00000552587014364_4360802.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000552587014632_7140802.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST0000055258701491_1630802.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST00000374825513555_559275802.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000374831513555_559275802.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000383108013555_5590802.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000395287413555_559275837.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000395289514555_559275837.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000399527013555_5590837.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000399528013555_5590802.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000399529013555_5590802.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000414731013555_5590802.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000436979012555_5590755.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000438194013555_5590802.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000442863013555_5590837.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000448067013555_5590837.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000449085412555_559228755.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000449118013555_5590802.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000547286012555_5590755.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000547895014555_5590837.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000549126015555_5590837.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000549236012555_5590755.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000550142014555_5590837.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000552513012555_5590755.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000552587014555_5590802.0MotifNuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneBRD2chr19:13055304chr6:32944339ENST0000037482551361_64275802.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST0000037483151361_64275802.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST0000039528741361_64275837.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST0000039528951461_64275837.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST0000044908541261_64228755.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST0000037482551391_163275802.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST0000037483151391_163275802.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST0000039528741391_163275837.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST0000039528951491_163275837.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST0000044908541291_163228755.0DomainBromo 1


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Fusion Gene Sequence for CALR-BRD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>12599_12599_1_CALR-BRD2_CALR_chr19_13055304_ENST00000316448_BRD2_chr6_32944339_ENST00000374825_length(transcript)=4271nt_BP=1903nt
CCGTCCGTACTGCAGAGCCGCTGCCGGAGGGTCGTTTTAAAGGGCCCGCGCGTTGCCGCCCCCTCGGCCCGCCATGCTGCTATCCGTGCC
GCTGCTGCTCGGCCTCCTCGGCCTGGCCGTCGCCGAGCCTGCCGTCTACTTCAAGGAGCAGTTTCTGGACGGAGACGGGTGGACTTCCCG
CTGGATCGAATCCAAACACAAGTCAGATTTTGGCAAATTCGTTCTCAGTTCCGGCAAGTTCTACGGTGACGAGGAGAAAGATAAAGGTTT
GCAGACAAGCCAGGATGCACGCTTTTATGCTCTGTCGGCCAGTTTCGAGCCTTTCAGCAACAAAGGCCAGACGCTGGTGGTGCAGTTCAC
GGTGAAACATGAGCAGAACATCGACTGTGGGGGCGGCTATGTGAAGCTGTTTCCTAATAGTTTGGACCAGACAGACATGCACGGAGACTC
AGAATACAACATCATGTTTGGTCCCGACATCTGTGGCCCTGGCACCAAGAAGGTTCATGTCATCTTCAACTACAAGGGCAAGAACGTGCT
GATCAACAAGGACATCCGTTGCAAGGATGATGAGTTTACACACCTGTACACACTGATTGTGCGGCCAGACAACACCTATGAGGTGAAGAT
TGACAACAGCCAGGTGGAGTCCGGCTCCTTGGAAGACGATTGGGACTTCCTGCCACCCAAGAAGATAAAGGATCCTGATGCTTCAAAACC
GGAAGACTGGGATGAGCGGGCCAAGATCGATGATCCCACAGACTCCAAGCCTGAGGACTGGGACAAGCCCGAGCATATCCCTGACCCTGA
TGCTAAGAAGCCCGAGGACTGGGATGAAGAGATGGACGGAGAGTGGGAACCCCCAGTGATTCAGAACCCTGAGTACAAGGGTGAGTGGAA
GCCCCGGCAGATCGACAACCCAGATTACAAGGGCACTTGGATCCACCCAGAAATTGACAACCCCGAGTATTCTCCCGATCCCAGTATCTA
TGCCTATGATAACTTTGGCGTGCTGGGCCTGGACCTCTGGCAGGTCAAGTCTGGCACCATCTTTGACAACTTCCTCATCACCAACGATGA
GGCATACGCTGAGGAGTTTGGCAACGAGACGTGGGGCGTAACAAAGGCAGCAGAGAAACAAATGAAGGACAAACAGGACGAGGAGCAGAG
GCTTAAGGAGGAGGAAGAAGACAAGAAACGCAAAGAGGAGGAGGAGGCAGAGGACAAGGAGGATGATGAGGACAAAGATGAGGATGAGGA
GGATGAGGAGGACAAGGAGGAAGATGAGGAGGAAGATGTCCCCGGCCAGGCCAAGGACGAGCTGTAGAGAGGCCTGCCTCCAGGGCTGGA
CTGAGGCCTGAGCGCTCCTGCCGCAGAGCTGGCCGCGCCAAATAATGTCTCTGTGAGACTCGAGAACTTTCATTTTTTTCCAGGCTGGTT
CGGATTTGGGGTGGATTTTGGTTTTGTTCCCCTCCTCCACTCTCCCCCACCCCCTCCCCGCCCTTTTTTTTTTTTTTTTTTAAACTGGTA
TTTTATCTTTGATTCTCCTTCAGCCCTCACCCCTGGTTCTCATCTTTCTTGATCAACATCTTTTCTTGCCTCTGTCCCCTTCTCTCATCT
CTTAGCTCCCCTCCAACCTGGGGGGCAGTGGTGTGGAGAAGCCACAGGCCTGAGATTTCATCTGCTCTCCTTCCTGGAGCCCAGAGGAGG
GCAGCAGAAGGGGGTGGTGTCTCCAACCCCCCAGCACTGAGGAAGAACGGGGCTCTTCTCATTTCACCCCTCCCTTTCTCCCCTGCCCCC
AGGACTGGGCCACTTCTGGGTGGGGCAGTGGGTCCCAGATTGGCTCACACTGAGAATGTAAGAACTACAAACAAAATTTCTATTAAATTA
AATTTTGTGTCTCAAAAAAGGCGTAAAGCGGAAAGCAGATACTACCACCCCTACACCTACAGCCATCTTGGCTCCTGGTTCTCCAGCTAG
CCCTCCTGGGAGTCTTGAGCCTAAGGCAGCACGGCTTCCCCCTATGCGTAGAGAGAGTGGTCGCCCCATCAAGCCCCCACGCAAAGACTT
GCCTGACTCTCAGCAACAACACCAGAGCTCTAAGAAAGGAAAGCTTTCAGAACAGTTAAAACATTGCAATGGCATTTTGAAGGAGTTACT
CTCTAAGAAGCATGCTGCCTATGCTTGGCCTTTCTATAAACCAGTGGATGCTTCTGCACTTGGCCTGCATGACTACCATGACATCATTAA
GCACCCCATGGACCTCAGCACTGTCAAGCGGAAGATGGAGAACCGTGATTACCGGGATGCACAGGAGTTTGCTGCTGATGTACGGCTTAT
GTTCTCCAACTGCTATAAGTACAATCCCCCAGATCACGATGTTGTGGCAATGGCACGAAAGCTACAGGATGTATTTGAGTTCCGTTATGC
CAAGATGCCAGATGAACCACTAGAACCAGGGCCTTTACCAGTCTCTACTGCCATGCCCCCTGGCTTGGCCAAATCGTCTTCAGAGTCCTC
CAGTGAGGAAAGTAGCAGTGAGAGCTCCTCTGAGGAAGAGGAGGAGGAAGATGAGGAGGACGAGGAGGAAGAAGAGAGTGAAAGCTCAGA
CTCAGAGGAAGAAAGGGCTCATCGCTTAGCAGAACTACAGGAACAGCTTCGGGCAGTACATGAACAACTGGCTGCTCTGTCCCAGGGTCC
AATATCCAAGCCCAAGAGGAAAAGAGAGAAAAAAGAGAAAAAGAAGAAACGGAAGGCAGAGAAGCATCGAGGCCGAGCTGGGGCCGATGA
AGATGACAAGGGGCCTAGGGCACCCCGCCCACCTCAACCTAAGAAGTCCAAGAAAGCAAGTGGCAGTGGGGGTGGCAGTGCTGCTTTAGG
CCCTTCTGGCTTTGGACCTTCTGGAGGAAGTGGCACCAAGCTCCCCAAAAAGGCCACAAAGACAGCCCCACCTGCCCTGCCTACAGGTTA
TGATTCAGAGGAGGAGGAAGAGAGCAGGCCCATGAGTTACGATGAGAAGCGGCAGCTGAGCCTGGACATCAACAAATTACCTGGGGAGAA
GCTGGGCCGAGTTGTGCATATAATCCAAGCCAGGGAGCCCTCTTTACGTGATTCAAACCCAGAAGAGATTGAGATTGATTTTGAAACACT
CAAGCCATCCACACTTAGAGAGCTTGAGCGCTATGTCCTTTCCTGCCTACGTAAGAAACCCCGGAAGCCCTACACCATTAAGAAGCCTGT
GGGAAAGACAAAGGAGGAACTGGCTTTGGAGAAAAAGCGGGAATTAGAAAAGCGGTTACAAGATGTCAGCGGACAGCTCAATTCTACTAA
AAAGCCCCCCAAGAAAGCGAATGAGAAAACAGAGTCATCCTCTGCACAGCAAGTAGCAGTGTCACGCCTTAGCGCTTCCAGCTCCAGCTC
AGATTCCAGCTCCTCCTCTTCCTCGTCGTCGTCTTCAGACACCAGTGATTCAGACTCAGGCTAAGGGGTCAGGCCAGATGGGGCAGGAAG
GCTCCGCAGGACCGGACCCCTAGACCACCCTGCCCCACCTGCCCCTTCCCCCTTTGCTGTGACACTTCTTCATCTCACCCCCCCCCGCCC
CCCTCTAGGAGAGCTGGCTCTGCAGTGGGGGAGGGATGCAGGGACATTTACTGAAGGAGGGACATGGACAAAACAACATTGAATTCCCAG
CCCCATTGGGGAGTGATCTCTTGGACACAGAGCCCCCATTCAAAATGGGGCAGGGCAAGGGTGGGAGTGTGCAAAGCCCTGATCTGGAGT
TACCTGAGGCCACAGCTGCCCTATTCACTTCTAAGGGCCCTGTTTTGAGATTGTTTGTTCTAATTTATTTTAAGCTAGGTAAGGCTGGGG
GGAGGGTGGGGCCGTGGTCCCCTCAGCCTCCATGGGGAGGGAAGAAGGGGGAGCTCTTTTTTTACGTTGATTTTTTTTTTTCTACTCTGT
TTTCCCTTTTTCCTTCCGCTCCATTTGGGGCCCTGGGGGTTTCAGTCATCTCCCCATTTGGTCCCCTGGACTGTCTTTGTTGATTCTAAC
TTGTAAATAAAGAAAATATTATTCAAGTTTTGAGTTACCTTAATATTTGCTTTTGTAGTGTTTCAAAAGGAACATCATAAGAATTGTCTT
GATAATTTTGAGGGAAATATTACTGCAGTGAGAAAAGGCAATAGCTAACCTATAATTGGATTGTCTTAATTTTTAAACCAGTAGGCTTTT

>12599_12599_1_CALR-BRD2_CALR_chr19_13055304_ENST00000316448_BRD2_chr6_32944339_ENST00000374825_length(amino acids)=529AA_BP=3
MCLKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLS
KKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAK
MPDEPLEPGPLPVSTAMPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPI
SKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGPSGGSGTKLPKKATKTAPPALPTGYD
SEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKPVG

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Fusion Gene PPI Analysis for CALR-BRD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneCALRchr19:13055304chr6:32944339ENST00000316448-99237_270610.0418.0PPIB


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CALR-BRD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CALR-BRD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCALRC0001815Primary Myelofibrosis2CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneCALRC0026987Myelofibrosis2GENOMICS_ENGLAND;ORPHANET
HgeneCALRC0033975Psychotic Disorders2PSYGENET
HgeneCALRC0036337Schizoaffective Disorder2PSYGENET
HgeneCALRC0040028Thrombocythemia, Essential2CTD_human;ORPHANET
HgeneCALRC0349204Nonorganic psychosis2PSYGENET
HgeneCALRC0004565Melanoma, B161CTD_human
HgeneCALRC0005586Bipolar Disorder1PSYGENET
HgeneCALRC0009075Melanoma, Cloudman S911CTD_human
HgeneCALRC0009402Colorectal Carcinoma1CTD_human
HgeneCALRC0009404Colorectal Neoplasms1CTD_human
HgeneCALRC0018598Melanoma, Harding-Passey1CTD_human
HgeneCALRC0025205Melanoma, Experimental1CTD_human
HgeneCALRC0027022Myeloproliferative disease1CTD_human
HgeneCALRC0027626Neoplasm Invasiveness1CTD_human
HgeneCALRC0033578Prostatic Neoplasms1CTD_human
HgeneCALRC0033937Psychoses, Drug1PSYGENET
HgeneCALRC0036349Paranoid Schizophrenia1PSYGENET
HgeneCALRC0036939Shared Paranoid Disorder1PSYGENET
HgeneCALRC0151744Myocardial Ischemia1CTD_human
HgeneCALRC0279626Squamous cell carcinoma of esophagus1CTD_human
HgeneCALRC0376358Malignant neoplasm of prostate1CTD_human
HgeneCALRC3277671THROMBOCYTHEMIA 11GENOMICS_ENGLAND
TgeneC0017636Glioblastoma1CTD_human
TgeneC0025149Medulloblastoma1CTD_human
TgeneC0205833Medullomyoblastoma1CTD_human
TgeneC0278510Childhood Medulloblastoma1CTD_human
TgeneC0278876Adult Medulloblastoma1CTD_human
TgeneC0334588Giant Cell Glioblastoma1CTD_human
TgeneC0751291Desmoplastic Medulloblastoma1CTD_human
TgeneC1275668Melanotic medulloblastoma1CTD_human
TgeneC1621958Glioblastoma Multiforme1CTD_human;UNIPROT