Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:CALU-LAP3 (FusionGDB2 ID:HG813TG51056)

Fusion Gene Summary for CALU-LAP3

check button Fusion gene summary
Fusion gene informationFusion gene name: CALU-LAP3
Fusion gene ID: hg813tg51056
HgeneTgene
Gene symbol

CALU

LAP3

Gene ID

813

51056

Gene namecalumeninleucine aminopeptidase 3
Synonyms-HEL-S-106|LAP|LAPEP|PEPS
Cytomap('CALU')('LAP3')

7q32.1

4p15.32

Type of geneprotein-codingprotein-coding
DescriptioncalumeninIEF SSP 9302crocalbin-like proteinmultiple EF-hand proteincytosol aminopeptidaseLAP-3epididymis secretory protein Li 106leucyl aminopeptidasepeptidase Sproline aminopeptidaseprolyl aminopeptidase
Modification date2020031320200313
UniProtAcc

O43852

.
Ensembl transtripts involved in fusion geneENST00000535623, ENST00000249364, 
ENST00000449187, ENST00000479257, 
ENST00000538546, ENST00000542996, 
ENST00000535011, 
Fusion gene scores* DoF score12 X 13 X 3=4688 X 7 X 7=392
# samples 188
** MAII scorelog2(18/468*10)=-1.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/392*10)=-2.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CALU [Title/Abstract] AND LAP3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCALU(128407709)-LAP3(17600079), # samples:1
Anticipated loss of major functional domain due to fusion event.CALU-LAP3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CALU-LAP3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CALU-LAP3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CALU-LAP3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CALU (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across LAP3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRPTCGA-PJ-A5Z8-01ACALUchr7

128407709

+LAP3chr4

17600079

+


Top

Fusion Gene ORF analysis for CALU-LAP3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000535623ENST00000226299CALUchr7

128407709

+LAP3chr4

17600079

+
3UTR-3CDSENST00000535623ENST00000606142CALUchr7

128407709

+LAP3chr4

17600079

+
3UTR-3UTRENST00000535623ENST00000503467CALUchr7

128407709

+LAP3chr4

17600079

+
5CDS-3UTRENST00000249364ENST00000503467CALUchr7

128407709

+LAP3chr4

17600079

+
5CDS-3UTRENST00000449187ENST00000503467CALUchr7

128407709

+LAP3chr4

17600079

+
5CDS-3UTRENST00000479257ENST00000503467CALUchr7

128407709

+LAP3chr4

17600079

+
5CDS-3UTRENST00000538546ENST00000503467CALUchr7

128407709

+LAP3chr4

17600079

+
5CDS-3UTRENST00000542996ENST00000503467CALUchr7

128407709

+LAP3chr4

17600079

+
In-frameENST00000249364ENST00000226299CALUchr7

128407709

+LAP3chr4

17600079

+
In-frameENST00000249364ENST00000606142CALUchr7

128407709

+LAP3chr4

17600079

+
In-frameENST00000449187ENST00000226299CALUchr7

128407709

+LAP3chr4

17600079

+
In-frameENST00000449187ENST00000606142CALUchr7

128407709

+LAP3chr4

17600079

+
In-frameENST00000479257ENST00000226299CALUchr7

128407709

+LAP3chr4

17600079

+
In-frameENST00000479257ENST00000606142CALUchr7

128407709

+LAP3chr4

17600079

+
In-frameENST00000538546ENST00000226299CALUchr7

128407709

+LAP3chr4

17600079

+
In-frameENST00000538546ENST00000606142CALUchr7

128407709

+LAP3chr4

17600079

+
In-frameENST00000542996ENST00000226299CALUchr7

128407709

+LAP3chr4

17600079

+
In-frameENST00000542996ENST00000606142CALUchr7

128407709

+LAP3chr4

17600079

+
intron-3CDSENST00000535011ENST00000226299CALUchr7

128407709

+LAP3chr4

17600079

+
intron-3CDSENST00000535011ENST00000606142CALUchr7

128407709

+LAP3chr4

17600079

+
intron-3UTRENST00000535011ENST00000503467CALUchr7

128407709

+LAP3chr4

17600079

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000538546CALUchr7128407709+ENST00000226299LAP3chr417600079+14315691791051290
ENST00000538546CALUchr7128407709+ENST00000606142LAP3chr417600079+13975691791051290
ENST00000542996CALUchr7128407709+ENST00000226299LAP3chr417600079+267218108742292472
ENST00000542996CALUchr7128407709+ENST00000606142LAP3chr417600079+263818108742292472
ENST00000249364CALUchr7128407709+ENST00000226299LAP3chr417600079+18079451021427441
ENST00000249364CALUchr7128407709+ENST00000606142LAP3chr417600079+17739451021427441
ENST00000449187CALUchr7128407709+ENST00000226299LAP3chr417600079+1786924811406441
ENST00000449187CALUchr7128407709+ENST00000606142LAP3chr417600079+1752924811406441
ENST00000479257CALUchr7128407709+ENST00000226299LAP3chr417600079+256016987622180472
ENST00000479257CALUchr7128407709+ENST00000606142LAP3chr417600079+252616987622180472

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000538546ENST00000226299CALUchr7128407709+LAP3chr417600079+0.0005585830.99944144
ENST00000538546ENST00000606142CALUchr7128407709+LAP3chr417600079+0.0005599370.99944
ENST00000542996ENST00000226299CALUchr7128407709+LAP3chr417600079+0.0001724260.9998275
ENST00000542996ENST00000606142CALUchr7128407709+LAP3chr417600079+0.0001737930.99982625
ENST00000249364ENST00000226299CALUchr7128407709+LAP3chr417600079+0.0005926160.9994074
ENST00000249364ENST00000606142CALUchr7128407709+LAP3chr417600079+0.0005885390.99941146
ENST00000449187ENST00000226299CALUchr7128407709+LAP3chr417600079+0.0005423790.99945766
ENST00000449187ENST00000606142CALUchr7128407709+LAP3chr417600079+0.0005471850.99945277
ENST00000479257ENST00000226299CALUchr7128407709+LAP3chr417600079+0.0001892550.99981076
ENST00000479257ENST00000606142CALUchr7128407709+LAP3chr417600079+0.0001953680.9998047

Top

Fusion Genomic Features for CALU-LAP3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CALUchr7128407709+LAP3chr417600078+9.93E-121
CALUchr7128407709+LAP3chr417600078+9.93E-121

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for CALU-LAP3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:128407709/chr4:17600079)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CALU

O43852

.
FUNCTION: Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCALUchr7:128407709chr4:17600079ENST00000249364+67117_128281316.0Calcium binding2
HgeneCALUchr7:128407709chr4:17600079ENST00000249364+67164_175281316.0Calcium binding3%3B possibly ancestral
HgeneCALUchr7:128407709chr4:17600079ENST00000249364+67201_212281316.0Calcium binding4
HgeneCALUchr7:128407709chr4:17600079ENST00000249364+67242_253281316.0Calcium binding5
HgeneCALUchr7:128407709chr4:17600079ENST00000249364+6781_92281316.0Calcium binding1
HgeneCALUchr7:128407709chr4:17600079ENST00000449187+67117_128281316.0Calcium binding2
HgeneCALUchr7:128407709chr4:17600079ENST00000449187+67164_175281316.0Calcium binding3%3B possibly ancestral
HgeneCALUchr7:128407709chr4:17600079ENST00000449187+67201_212281316.0Calcium binding4
HgeneCALUchr7:128407709chr4:17600079ENST00000449187+67242_253281316.0Calcium binding5
HgeneCALUchr7:128407709chr4:17600079ENST00000449187+6781_92281316.0Calcium binding1
HgeneCALUchr7:128407709chr4:17600079ENST00000479257+78117_128289324.0Calcium binding2
HgeneCALUchr7:128407709chr4:17600079ENST00000479257+78164_175289324.0Calcium binding3%3B possibly ancestral
HgeneCALUchr7:128407709chr4:17600079ENST00000479257+78201_212289324.0Calcium binding4
HgeneCALUchr7:128407709chr4:17600079ENST00000479257+78242_253289324.0Calcium binding5
HgeneCALUchr7:128407709chr4:17600079ENST00000479257+78278_289289324.0Calcium binding6
HgeneCALUchr7:128407709chr4:17600079ENST00000479257+7881_92289324.0Calcium binding1
HgeneCALUchr7:128407709chr4:17600079ENST00000535623+89117_128353634.6666666666666Calcium binding2
HgeneCALUchr7:128407709chr4:17600079ENST00000535623+89164_175353634.6666666666666Calcium binding3%3B possibly ancestral
HgeneCALUchr7:128407709chr4:17600079ENST00000535623+89201_212353634.6666666666666Calcium binding4
HgeneCALUchr7:128407709chr4:17600079ENST00000535623+89242_253353634.6666666666666Calcium binding5
HgeneCALUchr7:128407709chr4:17600079ENST00000535623+89278_289353634.6666666666666Calcium binding6
HgeneCALUchr7:128407709chr4:17600079ENST00000535623+8981_92353634.6666666666666Calcium binding1
HgeneCALUchr7:128407709chr4:17600079ENST00000538546+45117_128130165.0Calcium binding2
HgeneCALUchr7:128407709chr4:17600079ENST00000538546+4581_92130165.0Calcium binding1
HgeneCALUchr7:128407709chr4:17600079ENST00000542996+78117_128289324.0Calcium binding2
HgeneCALUchr7:128407709chr4:17600079ENST00000542996+78164_175289324.0Calcium binding3%3B possibly ancestral
HgeneCALUchr7:128407709chr4:17600079ENST00000542996+78201_212289324.0Calcium binding4
HgeneCALUchr7:128407709chr4:17600079ENST00000542996+78242_253289324.0Calcium binding5
HgeneCALUchr7:128407709chr4:17600079ENST00000542996+78278_289289324.0Calcium binding6
HgeneCALUchr7:128407709chr4:17600079ENST00000542996+7881_92289324.0Calcium binding1
HgeneCALUchr7:128407709chr4:17600079ENST00000249364+67104_139281316.0DomainEF-hand 2
HgeneCALUchr7:128407709chr4:17600079ENST00000249364+67151_186281316.0DomainEF-hand 3
HgeneCALUchr7:128407709chr4:17600079ENST00000249364+67188_223281316.0DomainEF-hand 4
HgeneCALUchr7:128407709chr4:17600079ENST00000249364+67229_264281316.0DomainEF-hand 5
HgeneCALUchr7:128407709chr4:17600079ENST00000249364+6768_103281316.0DomainEF-hand 1
HgeneCALUchr7:128407709chr4:17600079ENST00000449187+67104_139281316.0DomainEF-hand 2
HgeneCALUchr7:128407709chr4:17600079ENST00000449187+67151_186281316.0DomainEF-hand 3
HgeneCALUchr7:128407709chr4:17600079ENST00000449187+67188_223281316.0DomainEF-hand 4
HgeneCALUchr7:128407709chr4:17600079ENST00000449187+67229_264281316.0DomainEF-hand 5
HgeneCALUchr7:128407709chr4:17600079ENST00000449187+6768_103281316.0DomainEF-hand 1
HgeneCALUchr7:128407709chr4:17600079ENST00000479257+78104_139289324.0DomainEF-hand 2
HgeneCALUchr7:128407709chr4:17600079ENST00000479257+78151_186289324.0DomainEF-hand 3
HgeneCALUchr7:128407709chr4:17600079ENST00000479257+78188_223289324.0DomainEF-hand 4
HgeneCALUchr7:128407709chr4:17600079ENST00000479257+78229_264289324.0DomainEF-hand 5
HgeneCALUchr7:128407709chr4:17600079ENST00000479257+7868_103289324.0DomainEF-hand 1
HgeneCALUchr7:128407709chr4:17600079ENST00000535623+89104_139353634.6666666666666DomainEF-hand 2
HgeneCALUchr7:128407709chr4:17600079ENST00000535623+89151_186353634.6666666666666DomainEF-hand 3
HgeneCALUchr7:128407709chr4:17600079ENST00000535623+89188_223353634.6666666666666DomainEF-hand 4
HgeneCALUchr7:128407709chr4:17600079ENST00000535623+89229_264353634.6666666666666DomainEF-hand 5
HgeneCALUchr7:128407709chr4:17600079ENST00000535623+89265_300353634.6666666666666DomainEF-hand 6
HgeneCALUchr7:128407709chr4:17600079ENST00000535623+8968_103353634.6666666666666DomainEF-hand 1
HgeneCALUchr7:128407709chr4:17600079ENST00000538546+4568_103130165.0DomainEF-hand 1
HgeneCALUchr7:128407709chr4:17600079ENST00000542996+78104_139289324.0DomainEF-hand 2
HgeneCALUchr7:128407709chr4:17600079ENST00000542996+78151_186289324.0DomainEF-hand 3
HgeneCALUchr7:128407709chr4:17600079ENST00000542996+78188_223289324.0DomainEF-hand 4
HgeneCALUchr7:128407709chr4:17600079ENST00000542996+78229_264289324.0DomainEF-hand 5
HgeneCALUchr7:128407709chr4:17600079ENST00000542996+7868_103289324.0DomainEF-hand 1
HgeneCALUchr7:128407709chr4:17600079ENST00000535623+89312_315353634.6666666666666MotifPrevents secretion from ER

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCALUchr7:128407709chr4:17600079ENST00000249364+67278_289281316.0Calcium binding6
HgeneCALUchr7:128407709chr4:17600079ENST00000449187+67278_289281316.0Calcium binding6
HgeneCALUchr7:128407709chr4:17600079ENST00000535011+16117_1280225.0Calcium binding2
HgeneCALUchr7:128407709chr4:17600079ENST00000535011+16164_1750225.0Calcium binding3%3B possibly ancestral
HgeneCALUchr7:128407709chr4:17600079ENST00000535011+16201_2120225.0Calcium binding4
HgeneCALUchr7:128407709chr4:17600079ENST00000535011+16242_2530225.0Calcium binding5
HgeneCALUchr7:128407709chr4:17600079ENST00000535011+16278_2890225.0Calcium binding6
HgeneCALUchr7:128407709chr4:17600079ENST00000535011+1681_920225.0Calcium binding1
HgeneCALUchr7:128407709chr4:17600079ENST00000538546+45164_175130165.0Calcium binding3%3B possibly ancestral
HgeneCALUchr7:128407709chr4:17600079ENST00000538546+45201_212130165.0Calcium binding4
HgeneCALUchr7:128407709chr4:17600079ENST00000538546+45242_253130165.0Calcium binding5
HgeneCALUchr7:128407709chr4:17600079ENST00000538546+45278_289130165.0Calcium binding6
HgeneCALUchr7:128407709chr4:17600079ENST00000249364+67265_300281316.0DomainEF-hand 6
HgeneCALUchr7:128407709chr4:17600079ENST00000449187+67265_300281316.0DomainEF-hand 6
HgeneCALUchr7:128407709chr4:17600079ENST00000479257+78265_300289324.0DomainEF-hand 6
HgeneCALUchr7:128407709chr4:17600079ENST00000535011+16104_1390225.0DomainEF-hand 2
HgeneCALUchr7:128407709chr4:17600079ENST00000535011+16151_1860225.0DomainEF-hand 3
HgeneCALUchr7:128407709chr4:17600079ENST00000535011+16188_2230225.0DomainEF-hand 4
HgeneCALUchr7:128407709chr4:17600079ENST00000535011+16229_2640225.0DomainEF-hand 5
HgeneCALUchr7:128407709chr4:17600079ENST00000535011+16265_3000225.0DomainEF-hand 6
HgeneCALUchr7:128407709chr4:17600079ENST00000535011+1668_1030225.0DomainEF-hand 1
HgeneCALUchr7:128407709chr4:17600079ENST00000538546+45104_139130165.0DomainEF-hand 2
HgeneCALUchr7:128407709chr4:17600079ENST00000538546+45151_186130165.0DomainEF-hand 3
HgeneCALUchr7:128407709chr4:17600079ENST00000538546+45188_223130165.0DomainEF-hand 4
HgeneCALUchr7:128407709chr4:17600079ENST00000538546+45229_264130165.0DomainEF-hand 5
HgeneCALUchr7:128407709chr4:17600079ENST00000538546+45265_300130165.0DomainEF-hand 6
HgeneCALUchr7:128407709chr4:17600079ENST00000542996+78265_300289324.0DomainEF-hand 6
HgeneCALUchr7:128407709chr4:17600079ENST00000249364+67312_315281316.0MotifPrevents secretion from ER
HgeneCALUchr7:128407709chr4:17600079ENST00000449187+67312_315281316.0MotifPrevents secretion from ER
HgeneCALUchr7:128407709chr4:17600079ENST00000479257+78312_315289324.0MotifPrevents secretion from ER
HgeneCALUchr7:128407709chr4:17600079ENST00000535011+16312_3150225.0MotifPrevents secretion from ER
HgeneCALUchr7:128407709chr4:17600079ENST00000538546+45312_315130165.0MotifPrevents secretion from ER
HgeneCALUchr7:128407709chr4:17600079ENST00000542996+78312_315289324.0MotifPrevents secretion from ER


Top

Fusion Gene Sequence for CALU-LAP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>12626_12626_1_CALU-LAP3_CALU_chr7_128407709_ENST00000249364_LAP3_chr4_17600079_ENST00000226299_length(transcript)=1807nt_BP=945nt
GCTTCCGGTTGGGCGGTGCTTGCGCGCGTGAGCTGAGCCGGTGGGTGAGCGGCGGCCACGGCATCCTGTGCTGTGGGGGCTACGAGGAAA
GATCTAATTATCATGGACCTGCGACAGTTTCTTATGTGCCTGTCCCTGTGCACAGCCTTTGCCTTGAGCAAACCCACAGAAAAGAAGGAC
CGTGTACATCATGAGCCTCAGCTCAGTGACAAGGTTCACAATGATGCTCAGAGTTTTGATTATGACCATGATGCCTTCTTGGGTGCTGAA
GAAGCAAAGACCTTTGATCAGCTGACACCAGAAGAGAGCAAGGAAAGGCTTGGAAAGATTGTAAGTAAAATAGATGGCGACAAGGACGGG
TTTGTCACTGTGGATGAGCTCAAAGACTGGATTAAATTTGCACAAAAGCGCTGGATTTACGAGGATGTAGAGCGACAGTGGAAGGGGCAT
GACCTCAATGAGGACGGCCTCGTTTCCTGGGAGGAGTATAAAAATGCCACCTACGGCTACGTTTTAGATGATCCAGATCCTGATGATGGA
TTTAACTATAAACAGATGATGGTTAGAGATGAGCGGAGGTTTAAAATGGCAGACAAGGATGGAGACCTCATTGCCACCAAGGAGGAGTTC
ACAGCTTTCCTGCACCCTGAGGAGTATGACTACATGAAAGATATAGTAGTACAGGAAACAATGGAAGATATAGATAAGAATGCTGATGGT
TTCATTGATCTAGAAGAGTATATTGGTGACATGTACAGCCATGATGGGAATACTGATGAGCCAGAATGGGTAAAGACAGAGCGAGAGCAG
TTTGTTGAGTTTCGGGATAAGAACCGTGATGGGAAGATGGACAAGGAAGAGACCAAAGACTGGATCCTTCCCTCAGACTATGATCATGCA
GAGGCAGAAGCCAGGCACCTGGTCTATGAATCAGACCAAAACAAGGTTGATAACACTGATGCTGAGGGGAGGCTCATACTGGCTGATGCG
CTCTGTTACGCACACACGTTTAACCCGAAGGTCATCCTCAATGCCGCCACCTTAACAGGTGCCATGGATGTAGCTTTGGGATCAGGTGCC
ACTGGGGTCTTTACCAATTCATCCTGGCTCTGGAACAAACTCTTCGAGGCCAGCATTGAAACAGGGGACCGTGTCTGGAGGATGCCTCTC
TTCGAACATTATACAAGACAGGTTGTAGATTGCCAGCTTGCTGATGTTAACAACATTGGAAAATACAGATCTGCAGGAGCATGTACAGCT
GCAGCATTCCTGAAAGAATTCGTAACTCATCCTAAGTGGGCACATTTAGACATAGCAGGCGTGATGACCAACAAAGATGAAGTTCCCTAT
CTACGGAAAGGCATGACTGGGAGGCCCACAAGGACTCTCATTGAGTTCTTACTTCGTTTCAGTCAAGACAATGCTTAGTTCAGATACTCA
AAAATGTCTTCACTCTGTCTTAAATTGGACAGTTGAACTTAAAAGGTTTTTGAATAAATGGATGAAAATCTTTTAACGGAGACAAAGGAT
GGTATTTAAAAATGTAGAACACAATGAAATTTGTATGCCTTGATTTTTTTTTCATTTCACACAAAGATTTATAAAGGTAAAGTTAATATC
TTACTTGATAAGGATTTTTAAGATACTCTATAAATGATTAAAATTTTTAGAACTTCCTAATCACTTTTCAGAGTATATGTTTTTCATTGA
GAAGCAAAATTGTAACTCAGATTTGTGATGCTAGGAACATGAGCAAACTGAAAATTACTATGCACTTGTCAGAAACAATAAATGCAACTT
GTTGTGC

>12626_12626_1_CALU-LAP3_CALU_chr7_128407709_ENST00000249364_LAP3_chr4_17600079_ENST00000226299_length(amino acids)=441AA_BP=281
MDLRQFLMCLSLCTAFALSKPTEKKDRVHHEPQLSDKVHNDAQSFDYDHDAFLGAEEAKTFDQLTPEESKERLGKIVSKIDGDKDGFVTV
DELKDWIKFAQKRWIYEDVERQWKGHDLNEDGLVSWEEYKNATYGYVLDDPDPDDGFNYKQMMVRDERRFKMADKDGDLIATKEEFTAFL
HPEEYDYMKDIVVQETMEDIDKNADGFIDLEEYIGDMYSHDGNTDEPEWVKTEREQFVEFRDKNRDGKMDKEETKDWILPSDYDHAEAEA
RHLVYESDQNKVDNTDAEGRLILADALCYAHTFNPKVILNAATLTGAMDVALGSGATGVFTNSSWLWNKLFEASIETGDRVWRMPLFEHY
TRQVVDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHLDIAGVMTNKDEVPYLRKGMTGRPTRTLIEFLLRFSQDNA

--------------------------------------------------------------
>12626_12626_2_CALU-LAP3_CALU_chr7_128407709_ENST00000249364_LAP3_chr4_17600079_ENST00000606142_length(transcript)=1773nt_BP=945nt
GCTTCCGGTTGGGCGGTGCTTGCGCGCGTGAGCTGAGCCGGTGGGTGAGCGGCGGCCACGGCATCCTGTGCTGTGGGGGCTACGAGGAAA
GATCTAATTATCATGGACCTGCGACAGTTTCTTATGTGCCTGTCCCTGTGCACAGCCTTTGCCTTGAGCAAACCCACAGAAAAGAAGGAC
CGTGTACATCATGAGCCTCAGCTCAGTGACAAGGTTCACAATGATGCTCAGAGTTTTGATTATGACCATGATGCCTTCTTGGGTGCTGAA
GAAGCAAAGACCTTTGATCAGCTGACACCAGAAGAGAGCAAGGAAAGGCTTGGAAAGATTGTAAGTAAAATAGATGGCGACAAGGACGGG
TTTGTCACTGTGGATGAGCTCAAAGACTGGATTAAATTTGCACAAAAGCGCTGGATTTACGAGGATGTAGAGCGACAGTGGAAGGGGCAT
GACCTCAATGAGGACGGCCTCGTTTCCTGGGAGGAGTATAAAAATGCCACCTACGGCTACGTTTTAGATGATCCAGATCCTGATGATGGA
TTTAACTATAAACAGATGATGGTTAGAGATGAGCGGAGGTTTAAAATGGCAGACAAGGATGGAGACCTCATTGCCACCAAGGAGGAGTTC
ACAGCTTTCCTGCACCCTGAGGAGTATGACTACATGAAAGATATAGTAGTACAGGAAACAATGGAAGATATAGATAAGAATGCTGATGGT
TTCATTGATCTAGAAGAGTATATTGGTGACATGTACAGCCATGATGGGAATACTGATGAGCCAGAATGGGTAAAGACAGAGCGAGAGCAG
TTTGTTGAGTTTCGGGATAAGAACCGTGATGGGAAGATGGACAAGGAAGAGACCAAAGACTGGATCCTTCCCTCAGACTATGATCATGCA
GAGGCAGAAGCCAGGCACCTGGTCTATGAATCAGACCAAAACAAGGTTGATAACACTGATGCTGAGGGGAGGCTCATACTGGCTGATGCG
CTCTGTTACGCACACACGTTTAACCCGAAGGTCATCCTCAATGCCGCCACCTTAACAGGTGCCATGGATGTAGCTTTGGGATCAGGTGCC
ACTGGGGTCTTTACCAATTCATCCTGGCTCTGGAACAAACTCTTCGAGGCCAGCATTGAAACAGGGGACCGTGTCTGGAGGATGCCTCTC
TTCGAACATTATACAAGACAGGTTGTAGATTGCCAGCTTGCTGATGTTAACAACATTGGAAAATACAGATCTGCAGGAGCATGTACAGCT
GCAGCATTCCTGAAAGAATTCGTAACTCATCCTAAGTGGGCACATTTAGACATAGCAGGCGTGATGACCAACAAAGATGAAGTTCCCTAT
CTACGGAAAGGCATGACTGGGAGGCCCACAAGGACTCTCATTGAGTTCTTACTTCGTTTCAGTCAAGACAATGCTTAGTTCAGATACTCA
AAAATGTCTTCACTCTGTCTTAAATTGGACAGTTGAACTTAAAAGGTTTTTGAATAAATGGATGAAAATCTTTTAACGGAGACAAAGGAT
GGTATTTAAAAATGTAGAACACAATGAAATTTGTATGCCTTGATTTTTTTTTCATTTCACACAAAGATTTATAAAGGTAAAGTTAATATC
TTACTTGATAAGGATTTTTAAGATACTCTATAAATGATTAAAATTTTTAGAACTTCCTAATCACTTTTCAGAGTATATGTTTTTCATTGA
GAAGCAAAATTGTAACTCAGATTTGTGATGCTAGGAACATGAGCAAACTGAAAATTACTATGC

>12626_12626_2_CALU-LAP3_CALU_chr7_128407709_ENST00000249364_LAP3_chr4_17600079_ENST00000606142_length(amino acids)=441AA_BP=281
MDLRQFLMCLSLCTAFALSKPTEKKDRVHHEPQLSDKVHNDAQSFDYDHDAFLGAEEAKTFDQLTPEESKERLGKIVSKIDGDKDGFVTV
DELKDWIKFAQKRWIYEDVERQWKGHDLNEDGLVSWEEYKNATYGYVLDDPDPDDGFNYKQMMVRDERRFKMADKDGDLIATKEEFTAFL
HPEEYDYMKDIVVQETMEDIDKNADGFIDLEEYIGDMYSHDGNTDEPEWVKTEREQFVEFRDKNRDGKMDKEETKDWILPSDYDHAEAEA
RHLVYESDQNKVDNTDAEGRLILADALCYAHTFNPKVILNAATLTGAMDVALGSGATGVFTNSSWLWNKLFEASIETGDRVWRMPLFEHY
TRQVVDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHLDIAGVMTNKDEVPYLRKGMTGRPTRTLIEFLLRFSQDNA

--------------------------------------------------------------
>12626_12626_3_CALU-LAP3_CALU_chr7_128407709_ENST00000449187_LAP3_chr4_17600079_ENST00000226299_length(transcript)=1786nt_BP=924nt
GCGCGCGTGAGCTGAGCCGGTGGGTGAGCGGCGGCCACGGCATCCTGTGCTGTGGGGGCTACGAGGAAAGATCTAATTATCATGGACCTG
CGACAGTTTCTTATGTGCCTGTCCCTGTGCACAGCCTTTGCCTTGAGCAAACCCACAGAAAAGAAGGACCGTGTACATCATGAGCCTCAG
CTCAGTGACAAGGTTCACAATGATGCTCAGAGTTTTGATTATGACCATGATGCCTTCTTGGGTGCTGAAGAAGCAAAGACCTTTGATCAG
CTGACACCAGAAGAGAGCAAGGAAAGGCTTGGAATGATTGTAGATAAAATAGACGCGGATAAAGATGGGTTTGTGACGGAGGGGGAGCTG
AAATCCTGGATTAAGCACGCCCAGAAGAAATACATATATGACAATGTTGAAAACCAATGGCAGGAGTTTGATATGAATCAAGACGGCTTA
ATCTCCTGGGATGAGTACAGAAACGTGACTTATGGCACTTACCTGGATGATCCAGATCCTGATGATGGATTTAACTATAAACAGATGATG
GTTAGAGATGAGCGGAGGTTTAAAATGGCAGACAAGGATGGAGACCTCATTGCCACCAAGGAGGAGTTCACAGCTTTCCTGCACCCTGAG
GAGTATGACTACATGAAAGATATAGTAGTACAGGAAACAATGGAAGATATAGATAAGAATGCTGATGGTTTCATTGATCTAGAAGAGTAT
ATTGGTGACATGTACAGCCATGATGGGAATACTGATGAGCCAGAATGGGTAAAGACAGAGCGAGAGCAGTTTGTTGAGTTTCGGGATAAG
AACCGTGATGGGAAGATGGACAAGGAAGAGACCAAAGACTGGATCCTTCCCTCAGACTATGATCATGCAGAGGCAGAAGCCAGGCACCTG
GTCTATGAATCAGACCAAAACAAGGTTGATAACACTGATGCTGAGGGGAGGCTCATACTGGCTGATGCGCTCTGTTACGCACACACGTTT
AACCCGAAGGTCATCCTCAATGCCGCCACCTTAACAGGTGCCATGGATGTAGCTTTGGGATCAGGTGCCACTGGGGTCTTTACCAATTCA
TCCTGGCTCTGGAACAAACTCTTCGAGGCCAGCATTGAAACAGGGGACCGTGTCTGGAGGATGCCTCTCTTCGAACATTATACAAGACAG
GTTGTAGATTGCCAGCTTGCTGATGTTAACAACATTGGAAAATACAGATCTGCAGGAGCATGTACAGCTGCAGCATTCCTGAAAGAATTC
GTAACTCATCCTAAGTGGGCACATTTAGACATAGCAGGCGTGATGACCAACAAAGATGAAGTTCCCTATCTACGGAAAGGCATGACTGGG
AGGCCCACAAGGACTCTCATTGAGTTCTTACTTCGTTTCAGTCAAGACAATGCTTAGTTCAGATACTCAAAAATGTCTTCACTCTGTCTT
AAATTGGACAGTTGAACTTAAAAGGTTTTTGAATAAATGGATGAAAATCTTTTAACGGAGACAAAGGATGGTATTTAAAAATGTAGAACA
CAATGAAATTTGTATGCCTTGATTTTTTTTTCATTTCACACAAAGATTTATAAAGGTAAAGTTAATATCTTACTTGATAAGGATTTTTAA
GATACTCTATAAATGATTAAAATTTTTAGAACTTCCTAATCACTTTTCAGAGTATATGTTTTTCATTGAGAAGCAAAATTGTAACTCAGA
TTTGTGATGCTAGGAACATGAGCAAACTGAAAATTACTATGCACTTGTCAGAAACAATAAATGCAACTTGTTGTGC

>12626_12626_3_CALU-LAP3_CALU_chr7_128407709_ENST00000449187_LAP3_chr4_17600079_ENST00000226299_length(amino acids)=441AA_BP=281
MDLRQFLMCLSLCTAFALSKPTEKKDRVHHEPQLSDKVHNDAQSFDYDHDAFLGAEEAKTFDQLTPEESKERLGMIVDKIDADKDGFVTE
GELKSWIKHAQKKYIYDNVENQWQEFDMNQDGLISWDEYRNVTYGTYLDDPDPDDGFNYKQMMVRDERRFKMADKDGDLIATKEEFTAFL
HPEEYDYMKDIVVQETMEDIDKNADGFIDLEEYIGDMYSHDGNTDEPEWVKTEREQFVEFRDKNRDGKMDKEETKDWILPSDYDHAEAEA
RHLVYESDQNKVDNTDAEGRLILADALCYAHTFNPKVILNAATLTGAMDVALGSGATGVFTNSSWLWNKLFEASIETGDRVWRMPLFEHY
TRQVVDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHLDIAGVMTNKDEVPYLRKGMTGRPTRTLIEFLLRFSQDNA

--------------------------------------------------------------
>12626_12626_4_CALU-LAP3_CALU_chr7_128407709_ENST00000449187_LAP3_chr4_17600079_ENST00000606142_length(transcript)=1752nt_BP=924nt
GCGCGCGTGAGCTGAGCCGGTGGGTGAGCGGCGGCCACGGCATCCTGTGCTGTGGGGGCTACGAGGAAAGATCTAATTATCATGGACCTG
CGACAGTTTCTTATGTGCCTGTCCCTGTGCACAGCCTTTGCCTTGAGCAAACCCACAGAAAAGAAGGACCGTGTACATCATGAGCCTCAG
CTCAGTGACAAGGTTCACAATGATGCTCAGAGTTTTGATTATGACCATGATGCCTTCTTGGGTGCTGAAGAAGCAAAGACCTTTGATCAG
CTGACACCAGAAGAGAGCAAGGAAAGGCTTGGAATGATTGTAGATAAAATAGACGCGGATAAAGATGGGTTTGTGACGGAGGGGGAGCTG
AAATCCTGGATTAAGCACGCCCAGAAGAAATACATATATGACAATGTTGAAAACCAATGGCAGGAGTTTGATATGAATCAAGACGGCTTA
ATCTCCTGGGATGAGTACAGAAACGTGACTTATGGCACTTACCTGGATGATCCAGATCCTGATGATGGATTTAACTATAAACAGATGATG
GTTAGAGATGAGCGGAGGTTTAAAATGGCAGACAAGGATGGAGACCTCATTGCCACCAAGGAGGAGTTCACAGCTTTCCTGCACCCTGAG
GAGTATGACTACATGAAAGATATAGTAGTACAGGAAACAATGGAAGATATAGATAAGAATGCTGATGGTTTCATTGATCTAGAAGAGTAT
ATTGGTGACATGTACAGCCATGATGGGAATACTGATGAGCCAGAATGGGTAAAGACAGAGCGAGAGCAGTTTGTTGAGTTTCGGGATAAG
AACCGTGATGGGAAGATGGACAAGGAAGAGACCAAAGACTGGATCCTTCCCTCAGACTATGATCATGCAGAGGCAGAAGCCAGGCACCTG
GTCTATGAATCAGACCAAAACAAGGTTGATAACACTGATGCTGAGGGGAGGCTCATACTGGCTGATGCGCTCTGTTACGCACACACGTTT
AACCCGAAGGTCATCCTCAATGCCGCCACCTTAACAGGTGCCATGGATGTAGCTTTGGGATCAGGTGCCACTGGGGTCTTTACCAATTCA
TCCTGGCTCTGGAACAAACTCTTCGAGGCCAGCATTGAAACAGGGGACCGTGTCTGGAGGATGCCTCTCTTCGAACATTATACAAGACAG
GTTGTAGATTGCCAGCTTGCTGATGTTAACAACATTGGAAAATACAGATCTGCAGGAGCATGTACAGCTGCAGCATTCCTGAAAGAATTC
GTAACTCATCCTAAGTGGGCACATTTAGACATAGCAGGCGTGATGACCAACAAAGATGAAGTTCCCTATCTACGGAAAGGCATGACTGGG
AGGCCCACAAGGACTCTCATTGAGTTCTTACTTCGTTTCAGTCAAGACAATGCTTAGTTCAGATACTCAAAAATGTCTTCACTCTGTCTT
AAATTGGACAGTTGAACTTAAAAGGTTTTTGAATAAATGGATGAAAATCTTTTAACGGAGACAAAGGATGGTATTTAAAAATGTAGAACA
CAATGAAATTTGTATGCCTTGATTTTTTTTTCATTTCACACAAAGATTTATAAAGGTAAAGTTAATATCTTACTTGATAAGGATTTTTAA
GATACTCTATAAATGATTAAAATTTTTAGAACTTCCTAATCACTTTTCAGAGTATATGTTTTTCATTGAGAAGCAAAATTGTAACTCAGA
TTTGTGATGCTAGGAACATGAGCAAACTGAAAATTACTATGC

>12626_12626_4_CALU-LAP3_CALU_chr7_128407709_ENST00000449187_LAP3_chr4_17600079_ENST00000606142_length(amino acids)=441AA_BP=281
MDLRQFLMCLSLCTAFALSKPTEKKDRVHHEPQLSDKVHNDAQSFDYDHDAFLGAEEAKTFDQLTPEESKERLGMIVDKIDADKDGFVTE
GELKSWIKHAQKKYIYDNVENQWQEFDMNQDGLISWDEYRNVTYGTYLDDPDPDDGFNYKQMMVRDERRFKMADKDGDLIATKEEFTAFL
HPEEYDYMKDIVVQETMEDIDKNADGFIDLEEYIGDMYSHDGNTDEPEWVKTEREQFVEFRDKNRDGKMDKEETKDWILPSDYDHAEAEA
RHLVYESDQNKVDNTDAEGRLILADALCYAHTFNPKVILNAATLTGAMDVALGSGATGVFTNSSWLWNKLFEASIETGDRVWRMPLFEHY
TRQVVDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHLDIAGVMTNKDEVPYLRKGMTGRPTRTLIEFLLRFSQDNA

--------------------------------------------------------------
>12626_12626_5_CALU-LAP3_CALU_chr7_128407709_ENST00000479257_LAP3_chr4_17600079_ENST00000226299_length(transcript)=2560nt_BP=1698nt
ATCCTGTGCTGTGGGGGCTACGAGGAAAGGACCTCCCACCCTCCCCCACTGAGCTGCCTTCCCAGTGATGAAAGAAAAAATGTAAAAGCC
TGAAAACCCTTCTTCTTGATTTTTAATTTTTTTTTTTCCCTCTAAGACCTTAACCACTCTGGATAGTATCACGGGGTATCAGTAGAGTGT
GCTAAACAGATGTGTACTCTGCAGCTTCTTTGCAGGTTTTTTGTCACATTTTTCAGTCAAGTGTTCCAGCTTTGTGCTTGTTCATTAGAG
TCACCTGTGACTACAGAGATTCTGAAAGTTTGAATCAGGGCCTGGGAATCTGTACTTTGAACAGTACTACAGGTGGTATTTATGCCTAGG
CAAGTATGGGAAACAACTGTGCAGAAGGATAAAGACGTTCTTATCTATGACTAGACCATCTGAATGATTTGGCCTTTGAAGGTGACTCAA
GGTTGAGCCTGGATGTTGGAGACTTGGTGCTATAGACCAAGGAAGCTGCCAAGTATTTCGCTGGTTCCTAATCTCATGAACATCAGAATC
ACCTGAAAAACATTTAAAGCTACGAATGTCTGAATTCAGCTTCAGAGACTCTAAATCAATAGGAGAAACTTAAAGCTTCCTAGATGATTC
TAATAACCAGCCATGTTTGAAGACCAGACCACCAATGCGTACAAGAAGTAAAGGATTTGGAGTCAACATTTAAACCTTGGTTCTTTCACT
TTTAATTCTTATGAACTTGGGCAAAAGGATTAAAATTCTACTTTGGTATCTTTTGAAAGAAAACAGAAAGTGGACATTTTAACTATAAGT
TTCTTATCAGCCTACAATCAGATGAAGGAAACTGATCTAATTATCATGGACCTGCGACAGTTTCTTATGTGCCTGTCCCTGTGCACAGCC
TTTGCCTTGAGCAAACCCACAGAAAAGAAGGACCGTGTACATCATGAGCCTCAGCTCAGTGACAAGGTTCACAATGATGCTCAGAGTTTT
GATTATGACCATGATGCCTTCTTGGGTGCTGAAGAAGCAAAGACCTTTGATCAGCTGACACCAGAAGAGAGCAAGGAAAGGCTTGGAAAG
ATTGTAAGTAAAATAGATGGCGACAAGGACGGGTTTGTCACTGTGGATGAGCTCAAAGACTGGATTAAATTTGCACAAAAGCGCTGGATT
TACGAGGATGTAGAGCGACAGTGGAAGGGGCATGACCTCAATGAGGACGGCCTCGTTTCCTGGGAGGAGTATAAAAATGCCACCTACGGC
TACGTTTTAGATGATCCAGATCCTGATGATGGATTTAACTATAAACAGATGATGGTTAGAGATGAGCGGAGGTTTAAAATGGCAGACAAG
GATGGAGACCTCATTGCCACCAAGGAGGAGTTCACAGCTTTCCTGCACCCTGAGGAGTATGACTACATGAAAGATATAGTAGTACAGGAA
ACAATGGAAGATATAGATAAGAATGCTGATGGTTTCATTGATCTAGAAGAGTATATTGGTGACATGTACAGCCATGATGGGAATACTGAT
GAGCCAGAATGGGTAAAGACAGAGCGAGAGCAGTTTGTTGAGTTTCGGGATAAGAACCGTGATGGGAAGATGGACAAGGAAGAGACCAAA
GACTGGATCCTTCCCTCAGACTATGATCATGCAGAGGCAGAAGCCAGGCACCTGGTCTATGAATCAGACCAAAACAAGGTTGATAACACT
GATGCTGAGGGGAGGCTCATACTGGCTGATGCGCTCTGTTACGCACACACGTTTAACCCGAAGGTCATCCTCAATGCCGCCACCTTAACA
GGTGCCATGGATGTAGCTTTGGGATCAGGTGCCACTGGGGTCTTTACCAATTCATCCTGGCTCTGGAACAAACTCTTCGAGGCCAGCATT
GAAACAGGGGACCGTGTCTGGAGGATGCCTCTCTTCGAACATTATACAAGACAGGTTGTAGATTGCCAGCTTGCTGATGTTAACAACATT
GGAAAATACAGATCTGCAGGAGCATGTACAGCTGCAGCATTCCTGAAAGAATTCGTAACTCATCCTAAGTGGGCACATTTAGACATAGCA
GGCGTGATGACCAACAAAGATGAAGTTCCCTATCTACGGAAAGGCATGACTGGGAGGCCCACAAGGACTCTCATTGAGTTCTTACTTCGT
TTCAGTCAAGACAATGCTTAGTTCAGATACTCAAAAATGTCTTCACTCTGTCTTAAATTGGACAGTTGAACTTAAAAGGTTTTTGAATAA
ATGGATGAAAATCTTTTAACGGAGACAAAGGATGGTATTTAAAAATGTAGAACACAATGAAATTTGTATGCCTTGATTTTTTTTTCATTT
CACACAAAGATTTATAAAGGTAAAGTTAATATCTTACTTGATAAGGATTTTTAAGATACTCTATAAATGATTAAAATTTTTAGAACTTCC
TAATCACTTTTCAGAGTATATGTTTTTCATTGAGAAGCAAAATTGTAACTCAGATTTGTGATGCTAGGAACATGAGCAAACTGAAAATTA
CTATGCACTTGTCAGAAACAATAAATGCAACTTGTTGTGC

>12626_12626_5_CALU-LAP3_CALU_chr7_128407709_ENST00000479257_LAP3_chr4_17600079_ENST00000226299_length(amino acids)=472AA_BP=312
MVSFERKQKVDILTISFLSAYNQMKETDLIIMDLRQFLMCLSLCTAFALSKPTEKKDRVHHEPQLSDKVHNDAQSFDYDHDAFLGAEEAK
TFDQLTPEESKERLGKIVSKIDGDKDGFVTVDELKDWIKFAQKRWIYEDVERQWKGHDLNEDGLVSWEEYKNATYGYVLDDPDPDDGFNY
KQMMVRDERRFKMADKDGDLIATKEEFTAFLHPEEYDYMKDIVVQETMEDIDKNADGFIDLEEYIGDMYSHDGNTDEPEWVKTEREQFVE
FRDKNRDGKMDKEETKDWILPSDYDHAEAEARHLVYESDQNKVDNTDAEGRLILADALCYAHTFNPKVILNAATLTGAMDVALGSGATGV
FTNSSWLWNKLFEASIETGDRVWRMPLFEHYTRQVVDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHLDIAGVMTNKDEVPYLRK
GMTGRPTRTLIEFLLRFSQDNA

--------------------------------------------------------------
>12626_12626_6_CALU-LAP3_CALU_chr7_128407709_ENST00000479257_LAP3_chr4_17600079_ENST00000606142_length(transcript)=2526nt_BP=1698nt
ATCCTGTGCTGTGGGGGCTACGAGGAAAGGACCTCCCACCCTCCCCCACTGAGCTGCCTTCCCAGTGATGAAAGAAAAAATGTAAAAGCC
TGAAAACCCTTCTTCTTGATTTTTAATTTTTTTTTTTCCCTCTAAGACCTTAACCACTCTGGATAGTATCACGGGGTATCAGTAGAGTGT
GCTAAACAGATGTGTACTCTGCAGCTTCTTTGCAGGTTTTTTGTCACATTTTTCAGTCAAGTGTTCCAGCTTTGTGCTTGTTCATTAGAG
TCACCTGTGACTACAGAGATTCTGAAAGTTTGAATCAGGGCCTGGGAATCTGTACTTTGAACAGTACTACAGGTGGTATTTATGCCTAGG
CAAGTATGGGAAACAACTGTGCAGAAGGATAAAGACGTTCTTATCTATGACTAGACCATCTGAATGATTTGGCCTTTGAAGGTGACTCAA
GGTTGAGCCTGGATGTTGGAGACTTGGTGCTATAGACCAAGGAAGCTGCCAAGTATTTCGCTGGTTCCTAATCTCATGAACATCAGAATC
ACCTGAAAAACATTTAAAGCTACGAATGTCTGAATTCAGCTTCAGAGACTCTAAATCAATAGGAGAAACTTAAAGCTTCCTAGATGATTC
TAATAACCAGCCATGTTTGAAGACCAGACCACCAATGCGTACAAGAAGTAAAGGATTTGGAGTCAACATTTAAACCTTGGTTCTTTCACT
TTTAATTCTTATGAACTTGGGCAAAAGGATTAAAATTCTACTTTGGTATCTTTTGAAAGAAAACAGAAAGTGGACATTTTAACTATAAGT
TTCTTATCAGCCTACAATCAGATGAAGGAAACTGATCTAATTATCATGGACCTGCGACAGTTTCTTATGTGCCTGTCCCTGTGCACAGCC
TTTGCCTTGAGCAAACCCACAGAAAAGAAGGACCGTGTACATCATGAGCCTCAGCTCAGTGACAAGGTTCACAATGATGCTCAGAGTTTT
GATTATGACCATGATGCCTTCTTGGGTGCTGAAGAAGCAAAGACCTTTGATCAGCTGACACCAGAAGAGAGCAAGGAAAGGCTTGGAAAG
ATTGTAAGTAAAATAGATGGCGACAAGGACGGGTTTGTCACTGTGGATGAGCTCAAAGACTGGATTAAATTTGCACAAAAGCGCTGGATT
TACGAGGATGTAGAGCGACAGTGGAAGGGGCATGACCTCAATGAGGACGGCCTCGTTTCCTGGGAGGAGTATAAAAATGCCACCTACGGC
TACGTTTTAGATGATCCAGATCCTGATGATGGATTTAACTATAAACAGATGATGGTTAGAGATGAGCGGAGGTTTAAAATGGCAGACAAG
GATGGAGACCTCATTGCCACCAAGGAGGAGTTCACAGCTTTCCTGCACCCTGAGGAGTATGACTACATGAAAGATATAGTAGTACAGGAA
ACAATGGAAGATATAGATAAGAATGCTGATGGTTTCATTGATCTAGAAGAGTATATTGGTGACATGTACAGCCATGATGGGAATACTGAT
GAGCCAGAATGGGTAAAGACAGAGCGAGAGCAGTTTGTTGAGTTTCGGGATAAGAACCGTGATGGGAAGATGGACAAGGAAGAGACCAAA
GACTGGATCCTTCCCTCAGACTATGATCATGCAGAGGCAGAAGCCAGGCACCTGGTCTATGAATCAGACCAAAACAAGGTTGATAACACT
GATGCTGAGGGGAGGCTCATACTGGCTGATGCGCTCTGTTACGCACACACGTTTAACCCGAAGGTCATCCTCAATGCCGCCACCTTAACA
GGTGCCATGGATGTAGCTTTGGGATCAGGTGCCACTGGGGTCTTTACCAATTCATCCTGGCTCTGGAACAAACTCTTCGAGGCCAGCATT
GAAACAGGGGACCGTGTCTGGAGGATGCCTCTCTTCGAACATTATACAAGACAGGTTGTAGATTGCCAGCTTGCTGATGTTAACAACATT
GGAAAATACAGATCTGCAGGAGCATGTACAGCTGCAGCATTCCTGAAAGAATTCGTAACTCATCCTAAGTGGGCACATTTAGACATAGCA
GGCGTGATGACCAACAAAGATGAAGTTCCCTATCTACGGAAAGGCATGACTGGGAGGCCCACAAGGACTCTCATTGAGTTCTTACTTCGT
TTCAGTCAAGACAATGCTTAGTTCAGATACTCAAAAATGTCTTCACTCTGTCTTAAATTGGACAGTTGAACTTAAAAGGTTTTTGAATAA
ATGGATGAAAATCTTTTAACGGAGACAAAGGATGGTATTTAAAAATGTAGAACACAATGAAATTTGTATGCCTTGATTTTTTTTTCATTT
CACACAAAGATTTATAAAGGTAAAGTTAATATCTTACTTGATAAGGATTTTTAAGATACTCTATAAATGATTAAAATTTTTAGAACTTCC
TAATCACTTTTCAGAGTATATGTTTTTCATTGAGAAGCAAAATTGTAACTCAGATTTGTGATGCTAGGAACATGAGCAAACTGAAAATTA
CTATGC

>12626_12626_6_CALU-LAP3_CALU_chr7_128407709_ENST00000479257_LAP3_chr4_17600079_ENST00000606142_length(amino acids)=472AA_BP=312
MVSFERKQKVDILTISFLSAYNQMKETDLIIMDLRQFLMCLSLCTAFALSKPTEKKDRVHHEPQLSDKVHNDAQSFDYDHDAFLGAEEAK
TFDQLTPEESKERLGKIVSKIDGDKDGFVTVDELKDWIKFAQKRWIYEDVERQWKGHDLNEDGLVSWEEYKNATYGYVLDDPDPDDGFNY
KQMMVRDERRFKMADKDGDLIATKEEFTAFLHPEEYDYMKDIVVQETMEDIDKNADGFIDLEEYIGDMYSHDGNTDEPEWVKTEREQFVE
FRDKNRDGKMDKEETKDWILPSDYDHAEAEARHLVYESDQNKVDNTDAEGRLILADALCYAHTFNPKVILNAATLTGAMDVALGSGATGV
FTNSSWLWNKLFEASIETGDRVWRMPLFEHYTRQVVDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHLDIAGVMTNKDEVPYLRK
GMTGRPTRTLIEFLLRFSQDNA

--------------------------------------------------------------
>12626_12626_7_CALU-LAP3_CALU_chr7_128407709_ENST00000538546_LAP3_chr4_17600079_ENST00000226299_length(transcript)=1431nt_BP=569nt
GATTGGTCGGGAGGCCGCCGGCGAGGCGGATGAGGGCGGGGTGCGGACCCGCTTCCGGTTGGGCGGTGCTTGCGCGCGTGAGCTGAGCCG
GTGGGTGAGCGGCGGCCACGGCATCCTGTGCTGTGGGGGCTACGAGGAAAGATGATCCAGATCCTGATGATGGATTTAACTATAAACAGA
TGATGGTTAGAGATGAGCGGAGGTTTAAAATGGCAGACAAGGATGGAGACCTCATTGCCACCAAGGAGGAGTTCACAGCTTTCCTGCACC
CTGAGGAGTATGACTACATGAAAGATATAGTAGTACAGGAAACAATGGAAGATATAGATAAGAATGCTGATGGTTTCATTGATCTAGAAG
AGTATATTGGTGACATGTACAGCCATGATGGGAATACTGATGAGCCAGAATGGGTAAAGACAGAGCGAGAGCAGTTTGTTGAGTTTCGGG
ATAAGAACCGTGATGGGAAGATGGACAAGGAAGAGACCAAAGACTGGATCCTTCCCTCAGACTATGATCATGCAGAGGCAGAAGCCAGGC
ACCTGGTCTATGAATCAGACCAAAACAAGGTTGATAACACTGATGCTGAGGGGAGGCTCATACTGGCTGATGCGCTCTGTTACGCACACA
CGTTTAACCCGAAGGTCATCCTCAATGCCGCCACCTTAACAGGTGCCATGGATGTAGCTTTGGGATCAGGTGCCACTGGGGTCTTTACCA
ATTCATCCTGGCTCTGGAACAAACTCTTCGAGGCCAGCATTGAAACAGGGGACCGTGTCTGGAGGATGCCTCTCTTCGAACATTATACAA
GACAGGTTGTAGATTGCCAGCTTGCTGATGTTAACAACATTGGAAAATACAGATCTGCAGGAGCATGTACAGCTGCAGCATTCCTGAAAG
AATTCGTAACTCATCCTAAGTGGGCACATTTAGACATAGCAGGCGTGATGACCAACAAAGATGAAGTTCCCTATCTACGGAAAGGCATGA
CTGGGAGGCCCACAAGGACTCTCATTGAGTTCTTACTTCGTTTCAGTCAAGACAATGCTTAGTTCAGATACTCAAAAATGTCTTCACTCT
GTCTTAAATTGGACAGTTGAACTTAAAAGGTTTTTGAATAAATGGATGAAAATCTTTTAACGGAGACAAAGGATGGTATTTAAAAATGTA
GAACACAATGAAATTTGTATGCCTTGATTTTTTTTTCATTTCACACAAAGATTTATAAAGGTAAAGTTAATATCTTACTTGATAAGGATT
TTTAAGATACTCTATAAATGATTAAAATTTTTAGAACTTCCTAATCACTTTTCAGAGTATATGTTTTTCATTGAGAAGCAAAATTGTAAC
TCAGATTTGTGATGCTAGGAACATGAGCAAACTGAAAATTACTATGCACTTGTCAGAAACAATAAATGCAACTTGTTGTGC

>12626_12626_7_CALU-LAP3_CALU_chr7_128407709_ENST00000538546_LAP3_chr4_17600079_ENST00000226299_length(amino acids)=290AA_BP=130
MMVRDERRFKMADKDGDLIATKEEFTAFLHPEEYDYMKDIVVQETMEDIDKNADGFIDLEEYIGDMYSHDGNTDEPEWVKTEREQFVEFR
DKNRDGKMDKEETKDWILPSDYDHAEAEARHLVYESDQNKVDNTDAEGRLILADALCYAHTFNPKVILNAATLTGAMDVALGSGATGVFT
NSSWLWNKLFEASIETGDRVWRMPLFEHYTRQVVDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHLDIAGVMTNKDEVPYLRKGM
TGRPTRTLIEFLLRFSQDNA

--------------------------------------------------------------
>12626_12626_8_CALU-LAP3_CALU_chr7_128407709_ENST00000538546_LAP3_chr4_17600079_ENST00000606142_length(transcript)=1397nt_BP=569nt
GATTGGTCGGGAGGCCGCCGGCGAGGCGGATGAGGGCGGGGTGCGGACCCGCTTCCGGTTGGGCGGTGCTTGCGCGCGTGAGCTGAGCCG
GTGGGTGAGCGGCGGCCACGGCATCCTGTGCTGTGGGGGCTACGAGGAAAGATGATCCAGATCCTGATGATGGATTTAACTATAAACAGA
TGATGGTTAGAGATGAGCGGAGGTTTAAAATGGCAGACAAGGATGGAGACCTCATTGCCACCAAGGAGGAGTTCACAGCTTTCCTGCACC
CTGAGGAGTATGACTACATGAAAGATATAGTAGTACAGGAAACAATGGAAGATATAGATAAGAATGCTGATGGTTTCATTGATCTAGAAG
AGTATATTGGTGACATGTACAGCCATGATGGGAATACTGATGAGCCAGAATGGGTAAAGACAGAGCGAGAGCAGTTTGTTGAGTTTCGGG
ATAAGAACCGTGATGGGAAGATGGACAAGGAAGAGACCAAAGACTGGATCCTTCCCTCAGACTATGATCATGCAGAGGCAGAAGCCAGGC
ACCTGGTCTATGAATCAGACCAAAACAAGGTTGATAACACTGATGCTGAGGGGAGGCTCATACTGGCTGATGCGCTCTGTTACGCACACA
CGTTTAACCCGAAGGTCATCCTCAATGCCGCCACCTTAACAGGTGCCATGGATGTAGCTTTGGGATCAGGTGCCACTGGGGTCTTTACCA
ATTCATCCTGGCTCTGGAACAAACTCTTCGAGGCCAGCATTGAAACAGGGGACCGTGTCTGGAGGATGCCTCTCTTCGAACATTATACAA
GACAGGTTGTAGATTGCCAGCTTGCTGATGTTAACAACATTGGAAAATACAGATCTGCAGGAGCATGTACAGCTGCAGCATTCCTGAAAG
AATTCGTAACTCATCCTAAGTGGGCACATTTAGACATAGCAGGCGTGATGACCAACAAAGATGAAGTTCCCTATCTACGGAAAGGCATGA
CTGGGAGGCCCACAAGGACTCTCATTGAGTTCTTACTTCGTTTCAGTCAAGACAATGCTTAGTTCAGATACTCAAAAATGTCTTCACTCT
GTCTTAAATTGGACAGTTGAACTTAAAAGGTTTTTGAATAAATGGATGAAAATCTTTTAACGGAGACAAAGGATGGTATTTAAAAATGTA
GAACACAATGAAATTTGTATGCCTTGATTTTTTTTTCATTTCACACAAAGATTTATAAAGGTAAAGTTAATATCTTACTTGATAAGGATT
TTTAAGATACTCTATAAATGATTAAAATTTTTAGAACTTCCTAATCACTTTTCAGAGTATATGTTTTTCATTGAGAAGCAAAATTGTAAC
TCAGATTTGTGATGCTAGGAACATGAGCAAACTGAAAATTACTATGC

>12626_12626_8_CALU-LAP3_CALU_chr7_128407709_ENST00000538546_LAP3_chr4_17600079_ENST00000606142_length(amino acids)=290AA_BP=130
MMVRDERRFKMADKDGDLIATKEEFTAFLHPEEYDYMKDIVVQETMEDIDKNADGFIDLEEYIGDMYSHDGNTDEPEWVKTEREQFVEFR
DKNRDGKMDKEETKDWILPSDYDHAEAEARHLVYESDQNKVDNTDAEGRLILADALCYAHTFNPKVILNAATLTGAMDVALGSGATGVFT
NSSWLWNKLFEASIETGDRVWRMPLFEHYTRQVVDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHLDIAGVMTNKDEVPYLRKGM
TGRPTRTLIEFLLRFSQDNA

--------------------------------------------------------------
>12626_12626_9_CALU-LAP3_CALU_chr7_128407709_ENST00000542996_LAP3_chr4_17600079_ENST00000226299_length(transcript)=2672nt_BP=1810nt
GATTGGTCGGGAGGCCGCCGGCGAGGCGGATGAGGGCGGGGTGCGGACCCGCTTCCGGTTGGGCGGTGCTTGCGCGCGTGAGCTGAGCCG
GTGGGTGAGCGGCGGCCACGGCATCCTGTGCTGTGGGGGCTACGAGGAAAGGACCTCCCACCCTCCCCCACTGAGCTGCCTTCCCAGTGA
TGAAAGAAAAAATGTAAAAGCCTGAAAACCCTTCTTCTTGATTTTTAATTTTTTTTTTTCCCTCTAAGACCTTAACCACTCTGGATAGTA
TCACGGGGTATCAGTAGAGTGTGCTAAACAGATGTGTACTCTGCAGCTTCTTTGCAGGTTTTTTGTCACATTTTTCAGTCAAGTGTTCCA
GCTTTGTGCTTGTTCATTAGAGTCACCTGTGACTACAGAGATTCTGAAAGTTTGAATCAGGGCCTGGGAATCTGTACTTTGAACAGTACT
ACAGGTGGTATTTATGCCTAGGCAAGTATGGGAAACAACTGTGCAGAAGGATAAAGACGTTCTTATCTATGACTAGACCATCTGAATGAT
TTGGCCTTTGAAGGTGACTCAAGGTTGAGCCTGGATGTTGGAGACTTGGTGCTATAGACCAAGGAAGCTGCCAAGTATTTCGCTGGTTCC
TAATCTCATGAACATCAGAATCACCTGAAAAACATTTAAAGCTACGAATGTCTGAATTCAGCTTCAGAGACTCTAAATCAATAGGAGAAA
CTTAAAGCTTCCTAGATGATTCTAATAACCAGCCATGTTTGAAGACCAGACCACCAATGCGTACAAGAAGTAAAGGATTTGGAGTCAACA
TTTAAACCTTGGTTCTTTCACTTTTAATTCTTATGAACTTGGGCAAAAGGATTAAAATTCTACTTTGGTATCTTTTGAAAGAAAACAGAA
AGTGGACATTTTAACTATAAGTTTCTTATCAGCCTACAATCAGATGAAGGAAACTGATCTAATTATCATGGACCTGCGACAGTTTCTTAT
GTGCCTGTCCCTGTGCACAGCCTTTGCCTTGAGCAAACCCACAGAAAAGAAGGACCGTGTACATCATGAGCCTCAGCTCAGTGACAAGGT
TCACAATGATGCTCAGAGTTTTGATTATGACCATGATGCCTTCTTGGGTGCTGAAGAAGCAAAGACCTTTGATCAGCTGACACCAGAAGA
GAGCAAGGAAAGGCTTGGAATGATTGTAGATAAAATAGACGCGGATAAAGATGGGTTTGTGACGGAGGGGGAGCTGAAATCCTGGATTAA
GCACGCCCAGAAGAAATACATATATGACAATGTTGAAAACCAATGGCAGGAGTTTGATATGAATCAAGACGGCTTAATCTCCTGGGATGA
GTACAGAAACGTGACTTATGGCACTTACCTGGATGATCCAGATCCTGATGATGGATTTAACTATAAACAGATGATGGTTAGAGATGAGCG
GAGGTTTAAAATGGCAGACAAGGATGGAGACCTCATTGCCACCAAGGAGGAGTTCACAGCTTTCCTGCACCCTGAGGAGTATGACTACAT
GAAAGATATAGTAGTACAGGAAACAATGGAAGATATAGATAAGAATGCTGATGGTTTCATTGATCTAGAAGAGTATATTGGTGACATGTA
CAGCCATGATGGGAATACTGATGAGCCAGAATGGGTAAAGACAGAGCGAGAGCAGTTTGTTGAGTTTCGGGATAAGAACCGTGATGGGAA
GATGGACAAGGAAGAGACCAAAGACTGGATCCTTCCCTCAGACTATGATCATGCAGAGGCAGAAGCCAGGCACCTGGTCTATGAATCAGA
CCAAAACAAGGTTGATAACACTGATGCTGAGGGGAGGCTCATACTGGCTGATGCGCTCTGTTACGCACACACGTTTAACCCGAAGGTCAT
CCTCAATGCCGCCACCTTAACAGGTGCCATGGATGTAGCTTTGGGATCAGGTGCCACTGGGGTCTTTACCAATTCATCCTGGCTCTGGAA
CAAACTCTTCGAGGCCAGCATTGAAACAGGGGACCGTGTCTGGAGGATGCCTCTCTTCGAACATTATACAAGACAGGTTGTAGATTGCCA
GCTTGCTGATGTTAACAACATTGGAAAATACAGATCTGCAGGAGCATGTACAGCTGCAGCATTCCTGAAAGAATTCGTAACTCATCCTAA
GTGGGCACATTTAGACATAGCAGGCGTGATGACCAACAAAGATGAAGTTCCCTATCTACGGAAAGGCATGACTGGGAGGCCCACAAGGAC
TCTCATTGAGTTCTTACTTCGTTTCAGTCAAGACAATGCTTAGTTCAGATACTCAAAAATGTCTTCACTCTGTCTTAAATTGGACAGTTG
AACTTAAAAGGTTTTTGAATAAATGGATGAAAATCTTTTAACGGAGACAAAGGATGGTATTTAAAAATGTAGAACACAATGAAATTTGTA
TGCCTTGATTTTTTTTTCATTTCACACAAAGATTTATAAAGGTAAAGTTAATATCTTACTTGATAAGGATTTTTAAGATACTCTATAAAT
GATTAAAATTTTTAGAACTTCCTAATCACTTTTCAGAGTATATGTTTTTCATTGAGAAGCAAAATTGTAACTCAGATTTGTGATGCTAGG
AACATGAGCAAACTGAAAATTACTATGCACTTGTCAGAAACAATAAATGCAACTTGTTGTGC

>12626_12626_9_CALU-LAP3_CALU_chr7_128407709_ENST00000542996_LAP3_chr4_17600079_ENST00000226299_length(amino acids)=472AA_BP=312
MVSFERKQKVDILTISFLSAYNQMKETDLIIMDLRQFLMCLSLCTAFALSKPTEKKDRVHHEPQLSDKVHNDAQSFDYDHDAFLGAEEAK
TFDQLTPEESKERLGMIVDKIDADKDGFVTEGELKSWIKHAQKKYIYDNVENQWQEFDMNQDGLISWDEYRNVTYGTYLDDPDPDDGFNY
KQMMVRDERRFKMADKDGDLIATKEEFTAFLHPEEYDYMKDIVVQETMEDIDKNADGFIDLEEYIGDMYSHDGNTDEPEWVKTEREQFVE
FRDKNRDGKMDKEETKDWILPSDYDHAEAEARHLVYESDQNKVDNTDAEGRLILADALCYAHTFNPKVILNAATLTGAMDVALGSGATGV
FTNSSWLWNKLFEASIETGDRVWRMPLFEHYTRQVVDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHLDIAGVMTNKDEVPYLRK
GMTGRPTRTLIEFLLRFSQDNA

--------------------------------------------------------------
>12626_12626_10_CALU-LAP3_CALU_chr7_128407709_ENST00000542996_LAP3_chr4_17600079_ENST00000606142_length(transcript)=2638nt_BP=1810nt
GATTGGTCGGGAGGCCGCCGGCGAGGCGGATGAGGGCGGGGTGCGGACCCGCTTCCGGTTGGGCGGTGCTTGCGCGCGTGAGCTGAGCCG
GTGGGTGAGCGGCGGCCACGGCATCCTGTGCTGTGGGGGCTACGAGGAAAGGACCTCCCACCCTCCCCCACTGAGCTGCCTTCCCAGTGA
TGAAAGAAAAAATGTAAAAGCCTGAAAACCCTTCTTCTTGATTTTTAATTTTTTTTTTTCCCTCTAAGACCTTAACCACTCTGGATAGTA
TCACGGGGTATCAGTAGAGTGTGCTAAACAGATGTGTACTCTGCAGCTTCTTTGCAGGTTTTTTGTCACATTTTTCAGTCAAGTGTTCCA
GCTTTGTGCTTGTTCATTAGAGTCACCTGTGACTACAGAGATTCTGAAAGTTTGAATCAGGGCCTGGGAATCTGTACTTTGAACAGTACT
ACAGGTGGTATTTATGCCTAGGCAAGTATGGGAAACAACTGTGCAGAAGGATAAAGACGTTCTTATCTATGACTAGACCATCTGAATGAT
TTGGCCTTTGAAGGTGACTCAAGGTTGAGCCTGGATGTTGGAGACTTGGTGCTATAGACCAAGGAAGCTGCCAAGTATTTCGCTGGTTCC
TAATCTCATGAACATCAGAATCACCTGAAAAACATTTAAAGCTACGAATGTCTGAATTCAGCTTCAGAGACTCTAAATCAATAGGAGAAA
CTTAAAGCTTCCTAGATGATTCTAATAACCAGCCATGTTTGAAGACCAGACCACCAATGCGTACAAGAAGTAAAGGATTTGGAGTCAACA
TTTAAACCTTGGTTCTTTCACTTTTAATTCTTATGAACTTGGGCAAAAGGATTAAAATTCTACTTTGGTATCTTTTGAAAGAAAACAGAA
AGTGGACATTTTAACTATAAGTTTCTTATCAGCCTACAATCAGATGAAGGAAACTGATCTAATTATCATGGACCTGCGACAGTTTCTTAT
GTGCCTGTCCCTGTGCACAGCCTTTGCCTTGAGCAAACCCACAGAAAAGAAGGACCGTGTACATCATGAGCCTCAGCTCAGTGACAAGGT
TCACAATGATGCTCAGAGTTTTGATTATGACCATGATGCCTTCTTGGGTGCTGAAGAAGCAAAGACCTTTGATCAGCTGACACCAGAAGA
GAGCAAGGAAAGGCTTGGAATGATTGTAGATAAAATAGACGCGGATAAAGATGGGTTTGTGACGGAGGGGGAGCTGAAATCCTGGATTAA
GCACGCCCAGAAGAAATACATATATGACAATGTTGAAAACCAATGGCAGGAGTTTGATATGAATCAAGACGGCTTAATCTCCTGGGATGA
GTACAGAAACGTGACTTATGGCACTTACCTGGATGATCCAGATCCTGATGATGGATTTAACTATAAACAGATGATGGTTAGAGATGAGCG
GAGGTTTAAAATGGCAGACAAGGATGGAGACCTCATTGCCACCAAGGAGGAGTTCACAGCTTTCCTGCACCCTGAGGAGTATGACTACAT
GAAAGATATAGTAGTACAGGAAACAATGGAAGATATAGATAAGAATGCTGATGGTTTCATTGATCTAGAAGAGTATATTGGTGACATGTA
CAGCCATGATGGGAATACTGATGAGCCAGAATGGGTAAAGACAGAGCGAGAGCAGTTTGTTGAGTTTCGGGATAAGAACCGTGATGGGAA
GATGGACAAGGAAGAGACCAAAGACTGGATCCTTCCCTCAGACTATGATCATGCAGAGGCAGAAGCCAGGCACCTGGTCTATGAATCAGA
CCAAAACAAGGTTGATAACACTGATGCTGAGGGGAGGCTCATACTGGCTGATGCGCTCTGTTACGCACACACGTTTAACCCGAAGGTCAT
CCTCAATGCCGCCACCTTAACAGGTGCCATGGATGTAGCTTTGGGATCAGGTGCCACTGGGGTCTTTACCAATTCATCCTGGCTCTGGAA
CAAACTCTTCGAGGCCAGCATTGAAACAGGGGACCGTGTCTGGAGGATGCCTCTCTTCGAACATTATACAAGACAGGTTGTAGATTGCCA
GCTTGCTGATGTTAACAACATTGGAAAATACAGATCTGCAGGAGCATGTACAGCTGCAGCATTCCTGAAAGAATTCGTAACTCATCCTAA
GTGGGCACATTTAGACATAGCAGGCGTGATGACCAACAAAGATGAAGTTCCCTATCTACGGAAAGGCATGACTGGGAGGCCCACAAGGAC
TCTCATTGAGTTCTTACTTCGTTTCAGTCAAGACAATGCTTAGTTCAGATACTCAAAAATGTCTTCACTCTGTCTTAAATTGGACAGTTG
AACTTAAAAGGTTTTTGAATAAATGGATGAAAATCTTTTAACGGAGACAAAGGATGGTATTTAAAAATGTAGAACACAATGAAATTTGTA
TGCCTTGATTTTTTTTTCATTTCACACAAAGATTTATAAAGGTAAAGTTAATATCTTACTTGATAAGGATTTTTAAGATACTCTATAAAT
GATTAAAATTTTTAGAACTTCCTAATCACTTTTCAGAGTATATGTTTTTCATTGAGAAGCAAAATTGTAACTCAGATTTGTGATGCTAGG
AACATGAGCAAACTGAAAATTACTATGC

>12626_12626_10_CALU-LAP3_CALU_chr7_128407709_ENST00000542996_LAP3_chr4_17600079_ENST00000606142_length(amino acids)=472AA_BP=312
MVSFERKQKVDILTISFLSAYNQMKETDLIIMDLRQFLMCLSLCTAFALSKPTEKKDRVHHEPQLSDKVHNDAQSFDYDHDAFLGAEEAK
TFDQLTPEESKERLGMIVDKIDADKDGFVTEGELKSWIKHAQKKYIYDNVENQWQEFDMNQDGLISWDEYRNVTYGTYLDDPDPDDGFNY
KQMMVRDERRFKMADKDGDLIATKEEFTAFLHPEEYDYMKDIVVQETMEDIDKNADGFIDLEEYIGDMYSHDGNTDEPEWVKTEREQFVE
FRDKNRDGKMDKEETKDWILPSDYDHAEAEARHLVYESDQNKVDNTDAEGRLILADALCYAHTFNPKVILNAATLTGAMDVALGSGATGV
FTNSSWLWNKLFEASIETGDRVWRMPLFEHYTRQVVDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHLDIAGVMTNKDEVPYLRK
GMTGRPTRTLIEFLLRFSQDNA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CALU-LAP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for CALU-LAP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for CALU-LAP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCALUC0004238Atrial Fibrillation1CTD_human
HgeneCALUC0027626Neoplasm Invasiveness1CTD_human
HgeneCALUC0235480Paroxysmal atrial fibrillation1CTD_human
HgeneCALUC2585653Persistent atrial fibrillation1CTD_human
HgeneCALUC3468561familial atrial fibrillation1CTD_human
TgeneC0019193Hepatitis, Toxic1CTD_human
TgeneC0860207Drug-Induced Liver Disease1CTD_human
TgeneC1262760Hepatitis, Drug-Induced1CTD_human
TgeneC3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneC4279912Chemically-Induced Liver Toxicity1CTD_human