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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Fusion gene:TAF15-CDKN1C (FusionGDB2 ID:HG8148TG1028)

Fusion Gene Summary for TAF15-CDKN1C

check button Fusion gene summary
Fusion gene informationFusion gene name: TAF15-CDKN1C
Fusion gene ID: hg8148tg1028
HgeneTgene
Gene symbol

TAF15

CDKN1C

Gene ID

8148

1028

Gene nameTATA-box binding protein associated factor 15cyclin dependent kinase inhibitor 1C
SynonymsNpl3|RBP56|TAF2N|TAFII68BWCR|BWS|KIP2|WBS|p57|p57Kip2
Cytomap('TAF15')('CDKN1C')

17q12

11p15.4

Type of geneprotein-codingprotein-coding
DescriptionTATA-binding protein-associated factor 2NRBP56/CSMF fusionTAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDaTATA box binding protein (TBP)-associated factor, RNA polymerase II, N, 68kD (RNA-binding protein 56)TATA box-bincyclin-dependent kinase inhibitor 1Ccyclin-dependent kinase inhibitor 1C (p57, Kip2)cyclin-dependent kinase inhibitor p57
Modification date2020031320200315
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000592237, ENST00000311979, 
ENST00000588240, 
Fusion gene scores* DoF score14 X 14 X 8=15683 X 3 X 3=27
# samples 193
** MAII scorelog2(19/1568*10)=-3.04485423578426
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TAF15 [Title/Abstract] AND CDKN1C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTAF15(34142232)-CDKN1C(2906724), # samples:1
TAF15(34136580)-CDKN1C(2905364), # samples:1
Anticipated loss of major functional domain due to fusion event.TAF15-CDKN1C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TAF15-CDKN1C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TAF15-CDKN1C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TAF15-CDKN1C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TAF15-CDKN1C seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
TAF15-CDKN1C seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TAF15-CDKN1C seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTAF15

GO:0048255

mRNA stabilization

27378374

TgeneCDKN1C

GO:0033673

negative regulation of kinase activity

19170105

TgeneCDKN1C

GO:0042326

negative regulation of phosphorylation

19170105

TgeneCDKN1C

GO:0045892

negative regulation of transcription, DNA-templated

19170105


check buttonFusion gene breakpoints across TAF15 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CDKN1C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-A486-01ATAF15chr17

34136580

+CDKN1Cchr11

2905364

-
ChimerDB4STADTCGA-CD-A486-01ATAF15chr17

34142232

+CDKN1Cchr11

2906724

-


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Fusion Gene ORF analysis for TAF15-CDKN1C

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000592237ENST00000313407TAF15chr17

34136580

+CDKN1Cchr11

2905364

-
5UTR-3CDSENST00000592237ENST00000380725TAF15chr17

34136580

+CDKN1Cchr11

2905364

-
5UTR-3CDSENST00000592237ENST00000414822TAF15chr17

34136580

+CDKN1Cchr11

2905364

-
5UTR-3CDSENST00000592237ENST00000430149TAF15chr17

34136580

+CDKN1Cchr11

2905364

-
5UTR-3CDSENST00000592237ENST00000440480TAF15chr17

34136580

+CDKN1Cchr11

2905364

-
Frame-shiftENST00000311979ENST00000380725TAF15chr17

34136580

+CDKN1Cchr11

2905364

-
Frame-shiftENST00000588240ENST00000380725TAF15chr17

34136580

+CDKN1Cchr11

2905364

-
In-frameENST00000311979ENST00000313407TAF15chr17

34136580

+CDKN1Cchr11

2905364

-
In-frameENST00000311979ENST00000414822TAF15chr17

34136580

+CDKN1Cchr11

2905364

-
In-frameENST00000311979ENST00000430149TAF15chr17

34136580

+CDKN1Cchr11

2905364

-
In-frameENST00000311979ENST00000440480TAF15chr17

34136580

+CDKN1Cchr11

2905364

-
In-frameENST00000588240ENST00000313407TAF15chr17

34136580

+CDKN1Cchr11

2905364

-
In-frameENST00000588240ENST00000414822TAF15chr17

34136580

+CDKN1Cchr11

2905364

-
In-frameENST00000588240ENST00000430149TAF15chr17

34136580

+CDKN1Cchr11

2905364

-
In-frameENST00000588240ENST00000440480TAF15chr17

34136580

+CDKN1Cchr11

2905364

-
intron-5UTRENST00000311979ENST00000414822TAF15chr17

34142232

+CDKN1Cchr11

2906724

-
intron-5UTRENST00000311979ENST00000430149TAF15chr17

34142232

+CDKN1Cchr11

2906724

-
intron-5UTRENST00000588240ENST00000414822TAF15chr17

34142232

+CDKN1Cchr11

2906724

-
intron-5UTRENST00000588240ENST00000430149TAF15chr17

34142232

+CDKN1Cchr11

2906724

-
intron-5UTRENST00000592237ENST00000414822TAF15chr17

34142232

+CDKN1Cchr11

2906724

-
intron-5UTRENST00000592237ENST00000430149TAF15chr17

34142232

+CDKN1Cchr11

2906724

-
intron-intronENST00000311979ENST00000313407TAF15chr17

34142232

+CDKN1Cchr11

2906724

-
intron-intronENST00000311979ENST00000380725TAF15chr17

34142232

+CDKN1Cchr11

2906724

-
intron-intronENST00000311979ENST00000440480TAF15chr17

34142232

+CDKN1Cchr11

2906724

-
intron-intronENST00000588240ENST00000313407TAF15chr17

34142232

+CDKN1Cchr11

2906724

-
intron-intronENST00000588240ENST00000380725TAF15chr17

34142232

+CDKN1Cchr11

2906724

-
intron-intronENST00000588240ENST00000440480TAF15chr17

34142232

+CDKN1Cchr11

2906724

-
intron-intronENST00000592237ENST00000313407TAF15chr17

34142232

+CDKN1Cchr11

2906724

-
intron-intronENST00000592237ENST00000380725TAF15chr17

34142232

+CDKN1Cchr11

2906724

-
intron-intronENST00000592237ENST00000440480TAF15chr17

34142232

+CDKN1Cchr11

2906724

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000588240TAF15chr1734136580+ENST00000414822CDKN1Cchr112905364-9611222692780
ENST00000588240TAF15chr1734136580+ENST00000440480CDKN1Cchr112905364-95612237311386
ENST00000588240TAF15chr1734136580+ENST00000313407CDKN1Cchr112905364-93812215239480
ENST00000588240TAF15chr1734136580+ENST00000430149CDKN1Cchr112905364-59012215239480
ENST00000311979TAF15chr1734136580+ENST00000414822CDKN1Cchr112905364-92788235278
ENST00000311979TAF15chr1734136580+ENST00000440480CDKN1Cchr112905364-922883397986
ENST00000311979TAF15chr1734136580+ENST00000313407CDKN1Cchr112905364-9048811836080
ENST00000311979TAF15chr1734136580+ENST00000430149CDKN1Cchr112905364-5568811836080

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000588240ENST00000414822TAF15chr1734136580+CDKN1Cchr112905364-0.5759620.424038
ENST00000588240ENST00000440480TAF15chr1734136580+CDKN1Cchr112905364-0.58855930.4114407
ENST00000588240ENST00000313407TAF15chr1734136580+CDKN1Cchr112905364-0.868898870.13110113
ENST00000588240ENST00000430149TAF15chr1734136580+CDKN1Cchr112905364-0.87120010.12879987
ENST00000311979ENST00000414822TAF15chr1734136580+CDKN1Cchr112905364-0.53712610.4628739
ENST00000311979ENST00000440480TAF15chr1734136580+CDKN1Cchr112905364-0.550891160.44910884
ENST00000311979ENST00000313407TAF15chr1734136580+CDKN1Cchr112905364-0.92118010.078819916
ENST00000311979ENST00000430149TAF15chr1734136580+CDKN1Cchr112905364-0.91764210.08235789

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Fusion Genomic Features for TAF15-CDKN1C


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for TAF15-CDKN1C


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:34142232/chr11:2906724)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCDKN1Cchr17:34136580chr11:2905364ENST0000031340714278_281262268.3333333333333MotifNuclear localization signal
TgeneCDKN1Cchr17:34136580chr11:2905364ENST0000041482203278_281273147.33333333333334MotifNuclear localization signal
TgeneCDKN1Cchr17:34136580chr11:2905364ENST0000043014903278_28127360.333333333333336MotifNuclear localization signal
TgeneCDKN1Cchr17:34136580chr11:2905364ENST0000044048014278_281262258.3333333333333MotifNuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTAF15chr17:34136580chr11:2905364ENST00000311979+1161_2082590.0Compositional biasNote=Gln/Gly/Ser/Tyr-rich
HgeneTAF15chr17:34136580chr11:2905364ENST00000311979+116320_5902590.0Compositional biasNote=Arg/Gly-rich
HgeneTAF15chr17:34136580chr11:2905364ENST00000588240+1161_2082593.0Compositional biasNote=Gln/Gly/Ser/Tyr-rich
HgeneTAF15chr17:34136580chr11:2905364ENST00000588240+116320_5902593.0Compositional biasNote=Arg/Gly-rich
HgeneTAF15chr17:34136580chr11:2905364ENST00000311979+116234_3202590.0DomainRRM
HgeneTAF15chr17:34136580chr11:2905364ENST00000588240+116234_3202593.0DomainRRM
HgeneTAF15chr17:34136580chr11:2905364ENST00000311979+116407_5752590.0RegionNote=21 X approximate tandem repeats of D-R-[S%2CG](0%2C3)-G-G-Y-G-G
HgeneTAF15chr17:34136580chr11:2905364ENST00000588240+116407_5752593.0RegionNote=21 X approximate tandem repeats of D-R-[S%2CG](0%2C3)-G-G-Y-G-G
HgeneTAF15chr17:34136580chr11:2905364ENST00000311979+116407_4132590.0RepeatNote=1
HgeneTAF15chr17:34136580chr11:2905364ENST00000311979+116414_4202590.0RepeatNote=2
HgeneTAF15chr17:34136580chr11:2905364ENST00000311979+116421_4292590.0RepeatNote=3
HgeneTAF15chr17:34136580chr11:2905364ENST00000311979+116430_4392590.0RepeatNote=4
HgeneTAF15chr17:34136580chr11:2905364ENST00000311979+116440_4482590.0RepeatNote=5
HgeneTAF15chr17:34136580chr11:2905364ENST00000311979+116449_4572590.0RepeatNote=6
HgeneTAF15chr17:34136580chr11:2905364ENST00000311979+116458_4652590.0RepeatNote=7
HgeneTAF15chr17:34136580chr11:2905364ENST00000311979+116466_4732590.0RepeatNote=8
HgeneTAF15chr17:34136580chr11:2905364ENST00000311979+116474_4812590.0RepeatNote=9
HgeneTAF15chr17:34136580chr11:2905364ENST00000311979+116482_4882590.0RepeatNote=10
HgeneTAF15chr17:34136580chr11:2905364ENST00000311979+116489_4962590.0RepeatNote=11
HgeneTAF15chr17:34136580chr11:2905364ENST00000311979+116497_5032590.0RepeatNote=12
HgeneTAF15chr17:34136580chr11:2905364ENST00000311979+116504_5102590.0RepeatNote=13
HgeneTAF15chr17:34136580chr11:2905364ENST00000311979+116511_5172590.0RepeatNote=14
HgeneTAF15chr17:34136580chr11:2905364ENST00000311979+116518_5242590.0RepeatNote=15
HgeneTAF15chr17:34136580chr11:2905364ENST00000311979+116525_5332590.0RepeatNote=16
HgeneTAF15chr17:34136580chr11:2905364ENST00000311979+116534_5432590.0RepeatNote=17
HgeneTAF15chr17:34136580chr11:2905364ENST00000311979+116544_5512590.0RepeatNote=18
HgeneTAF15chr17:34136580chr11:2905364ENST00000311979+116552_5602590.0RepeatNote=19
HgeneTAF15chr17:34136580chr11:2905364ENST00000311979+116561_5682590.0RepeatNote=20
HgeneTAF15chr17:34136580chr11:2905364ENST00000311979+116569_5752590.0RepeatNote=21
HgeneTAF15chr17:34136580chr11:2905364ENST00000588240+116407_4132593.0RepeatNote=1
HgeneTAF15chr17:34136580chr11:2905364ENST00000588240+116414_4202593.0RepeatNote=2
HgeneTAF15chr17:34136580chr11:2905364ENST00000588240+116421_4292593.0RepeatNote=3
HgeneTAF15chr17:34136580chr11:2905364ENST00000588240+116430_4392593.0RepeatNote=4
HgeneTAF15chr17:34136580chr11:2905364ENST00000588240+116440_4482593.0RepeatNote=5
HgeneTAF15chr17:34136580chr11:2905364ENST00000588240+116449_4572593.0RepeatNote=6
HgeneTAF15chr17:34136580chr11:2905364ENST00000588240+116458_4652593.0RepeatNote=7
HgeneTAF15chr17:34136580chr11:2905364ENST00000588240+116466_4732593.0RepeatNote=8
HgeneTAF15chr17:34136580chr11:2905364ENST00000588240+116474_4812593.0RepeatNote=9
HgeneTAF15chr17:34136580chr11:2905364ENST00000588240+116482_4882593.0RepeatNote=10
HgeneTAF15chr17:34136580chr11:2905364ENST00000588240+116489_4962593.0RepeatNote=11
HgeneTAF15chr17:34136580chr11:2905364ENST00000588240+116497_5032593.0RepeatNote=12
HgeneTAF15chr17:34136580chr11:2905364ENST00000588240+116504_5102593.0RepeatNote=13
HgeneTAF15chr17:34136580chr11:2905364ENST00000588240+116511_5172593.0RepeatNote=14
HgeneTAF15chr17:34136580chr11:2905364ENST00000588240+116518_5242593.0RepeatNote=15
HgeneTAF15chr17:34136580chr11:2905364ENST00000588240+116525_5332593.0RepeatNote=16
HgeneTAF15chr17:34136580chr11:2905364ENST00000588240+116534_5432593.0RepeatNote=17
HgeneTAF15chr17:34136580chr11:2905364ENST00000588240+116544_5512593.0RepeatNote=18
HgeneTAF15chr17:34136580chr11:2905364ENST00000588240+116552_5602593.0RepeatNote=19
HgeneTAF15chr17:34136580chr11:2905364ENST00000588240+116561_5682593.0RepeatNote=20
HgeneTAF15chr17:34136580chr11:2905364ENST00000588240+116569_5752593.0RepeatNote=21
HgeneTAF15chr17:34136580chr11:2905364ENST00000311979+116354_3852590.0Zinc fingerRanBP2-type
HgeneTAF15chr17:34136580chr11:2905364ENST00000588240+116354_3852593.0Zinc fingerRanBP2-type
TgeneCDKN1Cchr17:34136580chr11:2905364ENST0000031340714156_213262268.3333333333333RegionNote=9 X 4 AA repeats of P-A-P-A
TgeneCDKN1Cchr17:34136580chr11:2905364ENST0000041482203156_213273147.33333333333334RegionNote=9 X 4 AA repeats of P-A-P-A
TgeneCDKN1Cchr17:34136580chr11:2905364ENST0000043014903156_21327360.333333333333336RegionNote=9 X 4 AA repeats of P-A-P-A
TgeneCDKN1Cchr17:34136580chr11:2905364ENST0000044048014156_213262258.3333333333333RegionNote=9 X 4 AA repeats of P-A-P-A
TgeneCDKN1Cchr17:34136580chr11:2905364ENST0000031340714156_159262268.3333333333333RepeatNote=1
TgeneCDKN1Cchr17:34136580chr11:2905364ENST0000031340714160_163262268.3333333333333RepeatNote=2
TgeneCDKN1Cchr17:34136580chr11:2905364ENST0000031340714180_183262268.3333333333333RepeatNote=3
TgeneCDKN1Cchr17:34136580chr11:2905364ENST0000031340714184_187262268.3333333333333RepeatNote=4
TgeneCDKN1Cchr17:34136580chr11:2905364ENST0000031340714188_191262268.3333333333333RepeatNote=5
TgeneCDKN1Cchr17:34136580chr11:2905364ENST0000031340714198_201262268.3333333333333RepeatNote=6
TgeneCDKN1Cchr17:34136580chr11:2905364ENST0000031340714202_205262268.3333333333333RepeatNote=7
TgeneCDKN1Cchr17:34136580chr11:2905364ENST0000031340714210_213262268.3333333333333RepeatNote=9
TgeneCDKN1Cchr17:34136580chr11:2905364ENST0000041482203156_159273147.33333333333334RepeatNote=1
TgeneCDKN1Cchr17:34136580chr11:2905364ENST0000041482203160_163273147.33333333333334RepeatNote=2
TgeneCDKN1Cchr17:34136580chr11:2905364ENST0000041482203180_183273147.33333333333334RepeatNote=3
TgeneCDKN1Cchr17:34136580chr11:2905364ENST0000041482203184_187273147.33333333333334RepeatNote=4
TgeneCDKN1Cchr17:34136580chr11:2905364ENST0000041482203188_191273147.33333333333334RepeatNote=5
TgeneCDKN1Cchr17:34136580chr11:2905364ENST0000041482203198_201273147.33333333333334RepeatNote=6
TgeneCDKN1Cchr17:34136580chr11:2905364ENST0000041482203202_205273147.33333333333334RepeatNote=7
TgeneCDKN1Cchr17:34136580chr11:2905364ENST0000041482203210_213273147.33333333333334RepeatNote=9
TgeneCDKN1Cchr17:34136580chr11:2905364ENST0000043014903156_15927360.333333333333336RepeatNote=1
TgeneCDKN1Cchr17:34136580chr11:2905364ENST0000043014903160_16327360.333333333333336RepeatNote=2
TgeneCDKN1Cchr17:34136580chr11:2905364ENST0000043014903180_18327360.333333333333336RepeatNote=3
TgeneCDKN1Cchr17:34136580chr11:2905364ENST0000043014903184_18727360.333333333333336RepeatNote=4
TgeneCDKN1Cchr17:34136580chr11:2905364ENST0000043014903188_19127360.333333333333336RepeatNote=5
TgeneCDKN1Cchr17:34136580chr11:2905364ENST0000043014903198_20127360.333333333333336RepeatNote=6
TgeneCDKN1Cchr17:34136580chr11:2905364ENST0000043014903202_20527360.333333333333336RepeatNote=7
TgeneCDKN1Cchr17:34136580chr11:2905364ENST0000043014903210_21327360.333333333333336RepeatNote=9
TgeneCDKN1Cchr17:34136580chr11:2905364ENST0000044048014156_159262258.3333333333333RepeatNote=1
TgeneCDKN1Cchr17:34136580chr11:2905364ENST0000044048014160_163262258.3333333333333RepeatNote=2
TgeneCDKN1Cchr17:34136580chr11:2905364ENST0000044048014180_183262258.3333333333333RepeatNote=3
TgeneCDKN1Cchr17:34136580chr11:2905364ENST0000044048014184_187262258.3333333333333RepeatNote=4
TgeneCDKN1Cchr17:34136580chr11:2905364ENST0000044048014188_191262258.3333333333333RepeatNote=5
TgeneCDKN1Cchr17:34136580chr11:2905364ENST0000044048014198_201262258.3333333333333RepeatNote=6
TgeneCDKN1Cchr17:34136580chr11:2905364ENST0000044048014202_205262258.3333333333333RepeatNote=7
TgeneCDKN1Cchr17:34136580chr11:2905364ENST0000044048014210_213262258.3333333333333RepeatNote=9


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Fusion Gene Sequence for TAF15-CDKN1C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>88730_88730_1_TAF15-CDKN1C_TAF15_chr17_34136580_ENST00000311979_CDKN1C_chr11_2905364_ENST00000313407_length(transcript)=904nt_BP=88nt
AGCTCCGGCCGCCGCGCCGCCTGGCTTTCGTATTCGTTGTTCTCGGCGGGCTGTGGGGCCTCCGCGCCGCGGCCGTTAGTCATGTCGGAT
TTCTTCGCCAAGCGCAAGAGATCAGCGCCTGAGAAGTCGTCGGGCGATGTCCCCGCGCCGTGTCCCTCTCCAAGCGCCGCCCCTGGCGTG
GGCTCGGTGGAGCAGACCCCGCGCAAGAGGCTGCGGTGAGCCAAAGCCCAAAGAGCCCCGAGGGAACCTGCCGGGGCAGCGGACGTTGGA
AGGGCGCTGGGCCTCGGCTGGGACCGTTCATGTAGCAGCAACCGGCGGCGGCTGCCGCAGAGCAGCGTTCGGTTTTGTTTTTAAATTTTG
AAAACTGTGCAATGTATTAATAACGTCTTTTTATATCTAAATGTATTCTGCACGAGAAGGTACACTGGTCCCAAGGTGTAAAGCTTTAAG
AGTCATTTATATAAAATGTTTAATCTCTGCTGAAACTCAGTGCAAAAAAAAGAAAAAAGAAAAAAAAAAGGAAAAAATAAAAAAACCATG
TATATTTGTACAAAAAGTTTTTAAAGTTATACTAACTTATATTTTCTATTTATGTCCAGGCGTGGACCGCTCTGCCACGCACTAGCTCGG
TTATTGGTTATGCCAAAGGCACTCTCCATCTCCCACATCTGGTTATTGACAAGTGTAACTTTATTTTCATCGCGGACTCTGGGGAAGGGG
GTCACTCACAAGCTGTAGCTGCCATACATGCCCATCTAGCTTGCAGTCTCTTCGCGCTTTCGCTGTCTCTCTTATTATGACTGTGTTTAT
CTGAAACTTGAAGACAAGTCTGTTAAAATGGTTCCTGAGCCGTCTGTACCACTGCCCCGGCCCCTCGTCCGCCGGGTTCTAAATAAAGAG

>88730_88730_1_TAF15-CDKN1C_TAF15_chr17_34136580_ENST00000311979_CDKN1C_chr11_2905364_ENST00000313407_length(amino acids)=80AA_BP=

--------------------------------------------------------------
>88730_88730_2_TAF15-CDKN1C_TAF15_chr17_34136580_ENST00000311979_CDKN1C_chr11_2905364_ENST00000414822_length(transcript)=927nt_BP=88nt
AGCTCCGGCCGCCGCGCCGCCTGGCTTTCGTATTCGTTGTTCTCGGCGGGCTGTGGGGCCTCCGCGCCGCGGCCGTTAGTCATGTCGGAT
TTCTTCGCCAAGCGCAAGAGATCAGCGCCTGAGAAGTCGTCGGGCGATGTCCCCGCGCCGTGTCCCTCTCCAAGCGCCGCCCCTGGCGTG
GGCTCGGTGGAGCAGACCCCGCGCAAGAGGCTGCGGTGAGCCAATTTAGAGCCCAAAGAGCCCCGAGGGAACCTGCCGGGGCAGCGGACG
TTGGAAGGGCGCTGGGCCTCGGCTGGGACCGTTCATGTAGCAGCAACCGGCGGCGGCTGCCGCAGAGCAGCGTTCGGTTTTGTTTTTAAA
TTTTGAAAACTGTGCAATGTATTAATAACGTCTTTTTATATCTAAATGTATTCTGCACGAGAAGGTACACTGGTCCCAAGGTGTAAAGCT
TTAAGAGTCATTTATATAAAATGTTTAATCTCTGCTGAAACTCAGTGCAAAAAAAAGAAAAAAGAAAAAAAAAAGGAAAAAATAAAAAAA
CCATGTATATTTGTACAAAAAGTTTTTAAAGTTATACTAACTTATATTTTCTATTTATGTCCAGGCGTGGACCGCTCTGCCACGCACTAG
CTCGGTTATTGGTTATGCCAAAGGCACTCTCCATCTCCCACATCTGGTTATTGACAAGTGTAACTTTATTTTCATCGCGGACTCTGGGGA
AGGGGGTCACTCACAAGCTGTAGCTGCCATACATGCCCATCTAGCTTGCAGTCTCTTCGCGCTTTCGCTGTCTCTCTTATTATGACTGTG
TTTATCTGAAACTTGAAGACAAGTCTGTTAAAATGGTTCCTGAGCCGTCTGTACCACTGCCCCGGCCCCTCGTCCGCCGGGTTCTAAATA

>88730_88730_2_TAF15-CDKN1C_TAF15_chr17_34136580_ENST00000311979_CDKN1C_chr11_2905364_ENST00000414822_length(amino acids)=78AA_BP=4

--------------------------------------------------------------
>88730_88730_3_TAF15-CDKN1C_TAF15_chr17_34136580_ENST00000311979_CDKN1C_chr11_2905364_ENST00000430149_length(transcript)=556nt_BP=88nt
AGCTCCGGCCGCCGCGCCGCCTGGCTTTCGTATTCGTTGTTCTCGGCGGGCTGTGGGGCCTCCGCGCCGCGGCCGTTAGTCATGTCGGAT
TTCTTCGCCAAGCGCAAGAGATCAGCGCCTGAGAAGTCGTCGGGCGATGTCCCCGCGCCGTGTCCCTCTCCAAGCGCCGCCCCTGGCGTG
GGCTCGGTGGAGCAGACCCCGCGCAAGAGGCTGCGGTGAGCCAAAGCCCAAAGAGCCCCGAGGGAACCTGCCGGGGCAGCGGACGTTGGA
AGGGCGCTGGGCCTCGGCTGGGACCGTTCATGTAGCAGCAACCGGCGGCGGCTGCCGCAGAGCAGCGTTCGGTTTTGTTTTTAAATTTTG
AAAACTGTGCAATGTATTAATAACGTCTTTTTATATCTAAATGTATTCTGCACGAGAAGGTACACTGGTCCCAAGGTGTAAAGCTTTAAG
AGTCATTTATATAAAATGTTTAATCTCTGCTGAAACTCAGTGCAAAAAAAAGAAAAAAGAAAAAAAAAAGGAAAAAATAAAAAAACCATG

>88730_88730_3_TAF15-CDKN1C_TAF15_chr17_34136580_ENST00000311979_CDKN1C_chr11_2905364_ENST00000430149_length(amino acids)=80AA_BP=

--------------------------------------------------------------
>88730_88730_4_TAF15-CDKN1C_TAF15_chr17_34136580_ENST00000311979_CDKN1C_chr11_2905364_ENST00000440480_length(transcript)=922nt_BP=88nt
AGCTCCGGCCGCCGCGCCGCCTGGCTTTCGTATTCGTTGTTCTCGGCGGGCTGTGGGGCCTCCGCGCCGCGGCCGTTAGTCATGTCGGAT
TTCTTCGCCAAGCGCAAGAGATCAGCGCCTGAGAAGTCGTCGGGCGATGTCCCCGCGCCGTGTCCCTCTCCAAGCGCCGCCCCTGGCGTG
GGCTCGGTGGAGCAGACCCCGCGCAAGAGGCTGCGGTGAGCCAATTTAGAGCCCAAAGAGCCCCGAGGGAACCTGCCGGGGCAGCGGACG
TTGGAAGGGCGCTGGGCCTCGGCTGGGACCGTTCATGTAGCAGCAACCGGCGGCGGCTGCCGCAGAGCAGCGTTCGGTTTTGTTTTTAAA
TTTTGAAAACTGTGCAATGTATTAATAACGTCTTTTTATATCTAAATGTATTCTGCACGAGAAGGTACACTGGTCCCAAGGTGTAAAGCT
TTAAGAGTCATTTATATAAAATGTTTAATCTCTGCTGAAACTCAGTGCAAAAAAAAGAAAAAAGAAAAAAAAAAGGAAAAAATAAAAAAA
CCATGTATATTTGTACAAAAAGTTTTTAAAGTTATACTAACTTATATTTTCTATTTATGTCCAGGCGTGGACCGCTCTGCCACGCACTAG
CTCGGTTATTGGTTATGCCAAAGGCACTCTCCATCTCCCACATCTGGTTATTGACAAGTGTAACTTTATTTTCATCGCGGACTCTGGGGA
AGGGGGTCACTCACAAGCTGTAGCTGCCATACATGCCCATCTAGCTTGCAGTCTCTTCGCGCTTTCGCTGTCTCTCTTATTATGACTGTG
TTTATCTGAAACTTGAAGACAAGTCTGTTAAAATGGTTCCTGAGCCGTCTGTACCACTGCCCCGGCCCCTCGTCCGCCGGGTTCTAAATA

>88730_88730_4_TAF15-CDKN1C_TAF15_chr17_34136580_ENST00000311979_CDKN1C_chr11_2905364_ENST00000440480_length(amino acids)=86AA_BP=1

--------------------------------------------------------------
>88730_88730_5_TAF15-CDKN1C_TAF15_chr17_34136580_ENST00000588240_CDKN1C_chr11_2905364_ENST00000313407_length(transcript)=938nt_BP=122nt
AGTCCGCCTCAGCCCGCCGCGCCGCCCTCAGTACAGCTCCGGCCGCCGCGCCGCCTGGCTTTCGTATTCGTTGTTCTCGGCGGGCTGTGG
GGCCTCCGCGCCGCGGCCGTTAGTCATGTCGGATTTCTTCGCCAAGCGCAAGAGATCAGCGCCTGAGAAGTCGTCGGGCGATGTCCCCGC
GCCGTGTCCCTCTCCAAGCGCCGCCCCTGGCGTGGGCTCGGTGGAGCAGACCCCGCGCAAGAGGCTGCGGTGAGCCAAAGCCCAAAGAGC
CCCGAGGGAACCTGCCGGGGCAGCGGACGTTGGAAGGGCGCTGGGCCTCGGCTGGGACCGTTCATGTAGCAGCAACCGGCGGCGGCTGCC
GCAGAGCAGCGTTCGGTTTTGTTTTTAAATTTTGAAAACTGTGCAATGTATTAATAACGTCTTTTTATATCTAAATGTATTCTGCACGAG
AAGGTACACTGGTCCCAAGGTGTAAAGCTTTAAGAGTCATTTATATAAAATGTTTAATCTCTGCTGAAACTCAGTGCAAAAAAAAGAAAA
AAGAAAAAAAAAAGGAAAAAATAAAAAAACCATGTATATTTGTACAAAAAGTTTTTAAAGTTATACTAACTTATATTTTCTATTTATGTC
CAGGCGTGGACCGCTCTGCCACGCACTAGCTCGGTTATTGGTTATGCCAAAGGCACTCTCCATCTCCCACATCTGGTTATTGACAAGTGT
AACTTTATTTTCATCGCGGACTCTGGGGAAGGGGGTCACTCACAAGCTGTAGCTGCCATACATGCCCATCTAGCTTGCAGTCTCTTCGCG
CTTTCGCTGTCTCTCTTATTATGACTGTGTTTATCTGAAACTTGAAGACAAGTCTGTTAAAATGGTTCCTGAGCCGTCTGTACCACTGCC

>88730_88730_5_TAF15-CDKN1C_TAF15_chr17_34136580_ENST00000588240_CDKN1C_chr11_2905364_ENST00000313407_length(amino acids)=80AA_BP=

--------------------------------------------------------------
>88730_88730_6_TAF15-CDKN1C_TAF15_chr17_34136580_ENST00000588240_CDKN1C_chr11_2905364_ENST00000414822_length(transcript)=961nt_BP=122nt
AGTCCGCCTCAGCCCGCCGCGCCGCCCTCAGTACAGCTCCGGCCGCCGCGCCGCCTGGCTTTCGTATTCGTTGTTCTCGGCGGGCTGTGG
GGCCTCCGCGCCGCGGCCGTTAGTCATGTCGGATTTCTTCGCCAAGCGCAAGAGATCAGCGCCTGAGAAGTCGTCGGGCGATGTCCCCGC
GCCGTGTCCCTCTCCAAGCGCCGCCCCTGGCGTGGGCTCGGTGGAGCAGACCCCGCGCAAGAGGCTGCGGTGAGCCAATTTAGAGCCCAA
AGAGCCCCGAGGGAACCTGCCGGGGCAGCGGACGTTGGAAGGGCGCTGGGCCTCGGCTGGGACCGTTCATGTAGCAGCAACCGGCGGCGG
CTGCCGCAGAGCAGCGTTCGGTTTTGTTTTTAAATTTTGAAAACTGTGCAATGTATTAATAACGTCTTTTTATATCTAAATGTATTCTGC
ACGAGAAGGTACACTGGTCCCAAGGTGTAAAGCTTTAAGAGTCATTTATATAAAATGTTTAATCTCTGCTGAAACTCAGTGCAAAAAAAA
GAAAAAAGAAAAAAAAAAGGAAAAAATAAAAAAACCATGTATATTTGTACAAAAAGTTTTTAAAGTTATACTAACTTATATTTTCTATTT
ATGTCCAGGCGTGGACCGCTCTGCCACGCACTAGCTCGGTTATTGGTTATGCCAAAGGCACTCTCCATCTCCCACATCTGGTTATTGACA
AGTGTAACTTTATTTTCATCGCGGACTCTGGGGAAGGGGGTCACTCACAAGCTGTAGCTGCCATACATGCCCATCTAGCTTGCAGTCTCT
TCGCGCTTTCGCTGTCTCTCTTATTATGACTGTGTTTATCTGAAACTTGAAGACAAGTCTGTTAAAATGGTTCCTGAGCCGTCTGTACCA

>88730_88730_6_TAF15-CDKN1C_TAF15_chr17_34136580_ENST00000588240_CDKN1C_chr11_2905364_ENST00000414822_length(amino acids)=80AA_BP=4

--------------------------------------------------------------
>88730_88730_7_TAF15-CDKN1C_TAF15_chr17_34136580_ENST00000588240_CDKN1C_chr11_2905364_ENST00000430149_length(transcript)=590nt_BP=122nt
AGTCCGCCTCAGCCCGCCGCGCCGCCCTCAGTACAGCTCCGGCCGCCGCGCCGCCTGGCTTTCGTATTCGTTGTTCTCGGCGGGCTGTGG
GGCCTCCGCGCCGCGGCCGTTAGTCATGTCGGATTTCTTCGCCAAGCGCAAGAGATCAGCGCCTGAGAAGTCGTCGGGCGATGTCCCCGC
GCCGTGTCCCTCTCCAAGCGCCGCCCCTGGCGTGGGCTCGGTGGAGCAGACCCCGCGCAAGAGGCTGCGGTGAGCCAAAGCCCAAAGAGC
CCCGAGGGAACCTGCCGGGGCAGCGGACGTTGGAAGGGCGCTGGGCCTCGGCTGGGACCGTTCATGTAGCAGCAACCGGCGGCGGCTGCC
GCAGAGCAGCGTTCGGTTTTGTTTTTAAATTTTGAAAACTGTGCAATGTATTAATAACGTCTTTTTATATCTAAATGTATTCTGCACGAG
AAGGTACACTGGTCCCAAGGTGTAAAGCTTTAAGAGTCATTTATATAAAATGTTTAATCTCTGCTGAAACTCAGTGCAAAAAAAAGAAAA

>88730_88730_7_TAF15-CDKN1C_TAF15_chr17_34136580_ENST00000588240_CDKN1C_chr11_2905364_ENST00000430149_length(amino acids)=80AA_BP=

--------------------------------------------------------------
>88730_88730_8_TAF15-CDKN1C_TAF15_chr17_34136580_ENST00000588240_CDKN1C_chr11_2905364_ENST00000440480_length(transcript)=956nt_BP=122nt
AGTCCGCCTCAGCCCGCCGCGCCGCCCTCAGTACAGCTCCGGCCGCCGCGCCGCCTGGCTTTCGTATTCGTTGTTCTCGGCGGGCTGTGG
GGCCTCCGCGCCGCGGCCGTTAGTCATGTCGGATTTCTTCGCCAAGCGCAAGAGATCAGCGCCTGAGAAGTCGTCGGGCGATGTCCCCGC
GCCGTGTCCCTCTCCAAGCGCCGCCCCTGGCGTGGGCTCGGTGGAGCAGACCCCGCGCAAGAGGCTGCGGTGAGCCAATTTAGAGCCCAA
AGAGCCCCGAGGGAACCTGCCGGGGCAGCGGACGTTGGAAGGGCGCTGGGCCTCGGCTGGGACCGTTCATGTAGCAGCAACCGGCGGCGG
CTGCCGCAGAGCAGCGTTCGGTTTTGTTTTTAAATTTTGAAAACTGTGCAATGTATTAATAACGTCTTTTTATATCTAAATGTATTCTGC
ACGAGAAGGTACACTGGTCCCAAGGTGTAAAGCTTTAAGAGTCATTTATATAAAATGTTTAATCTCTGCTGAAACTCAGTGCAAAAAAAA
GAAAAAAGAAAAAAAAAAGGAAAAAATAAAAAAACCATGTATATTTGTACAAAAAGTTTTTAAAGTTATACTAACTTATATTTTCTATTT
ATGTCCAGGCGTGGACCGCTCTGCCACGCACTAGCTCGGTTATTGGTTATGCCAAAGGCACTCTCCATCTCCCACATCTGGTTATTGACA
AGTGTAACTTTATTTTCATCGCGGACTCTGGGGAAGGGGGTCACTCACAAGCTGTAGCTGCCATACATGCCCATCTAGCTTGCAGTCTCT
TCGCGCTTTCGCTGTCTCTCTTATTATGACTGTGTTTATCTGAAACTTGAAGACAAGTCTGTTAAAATGGTTCCTGAGCCGTCTGTACCA

>88730_88730_8_TAF15-CDKN1C_TAF15_chr17_34136580_ENST00000588240_CDKN1C_chr11_2905364_ENST00000440480_length(amino acids)=86AA_BP=1

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TAF15-CDKN1C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TAF15-CDKN1C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TAF15-CDKN1C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTAF15C0002736Amyotrophic Lateral Sclerosis2GENOMICS_ENGLAND;ORPHANET
HgeneTAF15C0024623Malignant neoplasm of stomach1CTD_human
HgeneTAF15C0029463Osteosarcoma1CTD_human
HgeneTAF15C0038356Stomach Neoplasms1CTD_human
HgeneTAF15C0235874Disease Exacerbation1CTD_human
HgeneTAF15C1275278Extraskeletal Myxoid Chondrosarcoma1CTD_human;ORPHANET
HgeneTAF15C1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneC0004903Beckwith-Wiedemann Syndrome6CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC1846009Intrauterine Growth Retardation, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, And Genital Anomalies4CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0024121Lung Neoplasms2CTD_human
TgeneC0242379Malignant neoplasm of lung2CTD_human
TgeneC0001418Adenocarcinoma1CTD_human
TgeneC0014170Endometrial Neoplasms1CTD_human
TgeneC0014173Endometrial Hyperplasia1CTD_human
TgeneC0025202melanoma1CTD_human
TgeneC0027708Nephroblastoma1GENOMICS_ENGLAND
TgeneC0036341Schizophrenia1PSYGENET
TgeneC0175693Russell-Silver syndrome1GENOMICS_ENGLAND
TgeneC0205641Adenocarcinoma, Basal Cell1CTD_human
TgeneC0205642Adenocarcinoma, Oxyphilic1CTD_human
TgeneC0205643Carcinoma, Cribriform1CTD_human
TgeneC0205644Carcinoma, Granular Cell1CTD_human
TgeneC0205645Adenocarcinoma, Tubular1CTD_human
TgeneC0349578Complex Endometrial Hyperplasia1CTD_human
TgeneC0349579Atypical Endometrial Hyperplasia1CTD_human
TgeneC0456483Simple Endometrial Hyperplasia1CTD_human
TgeneC0476089Endometrial Carcinoma1CTD_human