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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANP32E-LAMTOR5 (FusionGDB2 ID:HG81611TG10542)

Fusion Gene Summary for ANP32E-LAMTOR5

check button Fusion gene summary
Fusion gene informationFusion gene name: ANP32E-LAMTOR5
Fusion gene ID: hg81611tg10542
HgeneTgene
Gene symbol

ANP32E

LAMTOR5

Gene ID

81611

10542

Gene nameacidic nuclear phosphoprotein 32 family member Elate endosomal/lysosomal adaptor, MAPK and MTOR activator 5
SynonymsLANP-L|LANPLHBXIP|XIP
Cytomap('ANP32E')('LAMTOR5')

1q21.2

1p13.3

Type of geneprotein-codingprotein-coding
Descriptionacidic leucine-rich nuclear phosphoprotein 32 family member ELANP-like proteinacidic (leucine-rich) nuclear phosphoprotein 32 family, member Eleucine-rich acidic nuclear protein likeragulator complex protein LAMTOR5HBV X-interacting proteinHBx-interacting proteinhepatitis B virus x interacting proteinhepatitis B virus x-interacting protein (9.6kD)late endosomal/lysosomal adaptor and MAPK and MTOR activator 5
Modification date2020031320200329
UniProtAcc

Q9BTT0

.
Ensembl transtripts involved in fusion geneENST00000314136, ENST00000369114, 
ENST00000369115, ENST00000369116, 
ENST00000369119, ENST00000436748, 
ENST00000533654, 
Fusion gene scores* DoF score5 X 5 X 3=752 X 2 X 2=8
# samples 52
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: ANP32E [Title/Abstract] AND LAMTOR5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANP32E(150195512)-LAMTOR5(110950316), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANP32E

GO:0043486

histone exchange

24463511

TgeneLAMTOR5

GO:0043066

negative regulation of apoptotic process

12773388

TgeneLAMTOR5

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

21343296

TgeneLAMTOR5

GO:0043154

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

12773388

TgeneLAMTOR5

GO:1900182

positive regulation of protein localization to nucleus

21343296

TgeneLAMTOR5

GO:1905636

positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding

21343296



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GT-01AANP32Echr1

150195512

-LAMTOR5chr1

110950316

-


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Fusion Gene ORF analysis for ANP32E-LAMTOR5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000314136ENST00000256644ANP32Echr1

150195512

-LAMTOR5chr1

110950316

-
5CDS-5UTRENST00000314136ENST00000602318ANP32Echr1

150195512

-LAMTOR5chr1

110950316

-
5CDS-5UTRENST00000369114ENST00000256644ANP32Echr1

150195512

-LAMTOR5chr1

110950316

-
5CDS-5UTRENST00000369114ENST00000602318ANP32Echr1

150195512

-LAMTOR5chr1

110950316

-
5CDS-5UTRENST00000369115ENST00000256644ANP32Echr1

150195512

-LAMTOR5chr1

110950316

-
5CDS-5UTRENST00000369115ENST00000602318ANP32Echr1

150195512

-LAMTOR5chr1

110950316

-
5CDS-5UTRENST00000369116ENST00000256644ANP32Echr1

150195512

-LAMTOR5chr1

110950316

-
5CDS-5UTRENST00000369116ENST00000602318ANP32Echr1

150195512

-LAMTOR5chr1

110950316

-
5CDS-5UTRENST00000369119ENST00000256644ANP32Echr1

150195512

-LAMTOR5chr1

110950316

-
5CDS-5UTRENST00000369119ENST00000602318ANP32Echr1

150195512

-LAMTOR5chr1

110950316

-
5CDS-5UTRENST00000436748ENST00000256644ANP32Echr1

150195512

-LAMTOR5chr1

110950316

-
5CDS-5UTRENST00000436748ENST00000602318ANP32Echr1

150195512

-LAMTOR5chr1

110950316

-
5CDS-intronENST00000314136ENST00000474861ANP32Echr1

150195512

-LAMTOR5chr1

110950316

-
5CDS-intronENST00000314136ENST00000483260ANP32Echr1

150195512

-LAMTOR5chr1

110950316

-
5CDS-intronENST00000314136ENST00000602858ANP32Echr1

150195512

-LAMTOR5chr1

110950316

-
5CDS-intronENST00000369114ENST00000474861ANP32Echr1

150195512

-LAMTOR5chr1

110950316

-
5CDS-intronENST00000369114ENST00000483260ANP32Echr1

150195512

-LAMTOR5chr1

110950316

-
5CDS-intronENST00000369114ENST00000602858ANP32Echr1

150195512

-LAMTOR5chr1

110950316

-
5CDS-intronENST00000369115ENST00000474861ANP32Echr1

150195512

-LAMTOR5chr1

110950316

-
5CDS-intronENST00000369115ENST00000483260ANP32Echr1

150195512

-LAMTOR5chr1

110950316

-
5CDS-intronENST00000369115ENST00000602858ANP32Echr1

150195512

-LAMTOR5chr1

110950316

-
5CDS-intronENST00000369116ENST00000474861ANP32Echr1

150195512

-LAMTOR5chr1

110950316

-
5CDS-intronENST00000369116ENST00000483260ANP32Echr1

150195512

-LAMTOR5chr1

110950316

-
5CDS-intronENST00000369116ENST00000602858ANP32Echr1

150195512

-LAMTOR5chr1

110950316

-
5CDS-intronENST00000369119ENST00000474861ANP32Echr1

150195512

-LAMTOR5chr1

110950316

-
5CDS-intronENST00000369119ENST00000483260ANP32Echr1

150195512

-LAMTOR5chr1

110950316

-
5CDS-intronENST00000369119ENST00000602858ANP32Echr1

150195512

-LAMTOR5chr1

110950316

-
5CDS-intronENST00000436748ENST00000474861ANP32Echr1

150195512

-LAMTOR5chr1

110950316

-
5CDS-intronENST00000436748ENST00000483260ANP32Echr1

150195512

-LAMTOR5chr1

110950316

-
5CDS-intronENST00000436748ENST00000602858ANP32Echr1

150195512

-LAMTOR5chr1

110950316

-
intron-5UTRENST00000533654ENST00000256644ANP32Echr1

150195512

-LAMTOR5chr1

110950316

-
intron-5UTRENST00000533654ENST00000602318ANP32Echr1

150195512

-LAMTOR5chr1

110950316

-
intron-intronENST00000533654ENST00000474861ANP32Echr1

150195512

-LAMTOR5chr1

110950316

-
intron-intronENST00000533654ENST00000483260ANP32Echr1

150195512

-LAMTOR5chr1

110950316

-
intron-intronENST00000533654ENST00000602858ANP32Echr1

150195512

-LAMTOR5chr1

110950316

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ANP32E-LAMTOR5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for ANP32E-LAMTOR5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:150195512/:110950316)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANP32E

Q9BTT0

.
FUNCTION: Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AZ1 from the nucleosome: removes H2A.Z/H2AZ1 from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AZ1 in the nucleosome. May stabilize the evicted H2A.Z/H2AZ1-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state (PubMed:24463511). Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis. {ECO:0000269|PubMed:24463511}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ANP32E-LAMTOR5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ANP32E-LAMTOR5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANP32E-LAMTOR5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANP32E-LAMTOR5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0006142Malignant neoplasm of breast1CTD_human
TgeneC0271650Impaired glucose tolerance1CTD_human
TgeneC0678222Breast Carcinoma1CTD_human
TgeneC1257931Mammary Neoplasms, Human1CTD_human
TgeneC1458155Mammary Neoplasms1CTD_human
TgeneC4704874Mammary Carcinoma, Human1CTD_human