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	Fusion Gene Summary
	Fusion Gene ORF analysis
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	Fusion Protein Features
	Fusion Gene Sequence
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Fusion gene:DIAPH3-DOK5 (FusionGDB2 ID:HG81624TG55816)

Fusion Gene Summary for DIAPH3-DOK5

Fusion gene summary

Fusion gene information	Fusion gene name: DIAPH3-DOK5
	Fusion gene ID: hg81624tg55816
		Hgene	Tgene
	Gene symbol	DIAPH3	DOK5
	Gene ID	81624	55816
	Gene name	diaphanous related formin 3	docking protein 5
	Synonyms	AN\|AUNA1\|DIA2\|DRF3\|NSDAN\|diap3\|mDia2	C20orf180\|IRS-6\|IRS6
	Cytomap	('DIAPH3')('DOK5') 13q21.2	20q13.2
	Type of gene	protein-coding	protein-coding
	Description	protein diaphanous homolog 3diaphanous homolog 3	docking protein 5downstream of tyrosine kinase 5insulin receptor substrate 6
	Modification date	20200313	20200320
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000267215, ENST00000377908, ENST00000400319, ENST00000400320, ENST00000400324, ENST00000400330, ENST00000465066,
Fusion gene scores	* DoF score	16 X 12 X 4=768	11 X 9 X 8=792
	# samples	18	12
	** MAII score	log2(18/768*10)=-2.09310940439148 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/792*10)=-2.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DIAPH3 [Title/Abstract] AND DOK5 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DIAPH3(60582677)-DOK5(53266953), # samples:2
Anticipated loss of major functional domain due to fusion event.	DIAPH3-DOK5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DIAPH3-DOK5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DIAPH3-DOK5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. DIAPH3-DOK5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. DIAPH3-DOK5 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across DIAPH3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DOK5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-KK-A59V	DIAPH3	chr13	60582677	-	DOK5	chr20	53266953	+

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Fusion Gene ORF analysis for DIAPH3-DOK5

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000267215	ENST00000491469	DIAPH3	chr13	60582677	-	DOK5	chr20	53266953	+
5CDS-intron	ENST00000377908	ENST00000491469	DIAPH3	chr13	60582677	-	DOK5	chr20	53266953	+
5CDS-intron	ENST00000400319	ENST00000491469	DIAPH3	chr13	60582677	-	DOK5	chr20	53266953	+
5CDS-intron	ENST00000400320	ENST00000491469	DIAPH3	chr13	60582677	-	DOK5	chr20	53266953	+
5CDS-intron	ENST00000400324	ENST00000491469	DIAPH3	chr13	60582677	-	DOK5	chr20	53266953	+
5CDS-intron	ENST00000400330	ENST00000491469	DIAPH3	chr13	60582677	-	DOK5	chr20	53266953	+
5UTR-3CDS	ENST00000465066	ENST00000262593	DIAPH3	chr13	60582677	-	DOK5	chr20	53266953	+
5UTR-3CDS	ENST00000465066	ENST00000395939	DIAPH3	chr13	60582677	-	DOK5	chr20	53266953	+
5UTR-intron	ENST00000465066	ENST00000491469	DIAPH3	chr13	60582677	-	DOK5	chr20	53266953	+
Frame-shift	ENST00000267215	ENST00000262593	DIAPH3	chr13	60582677	-	DOK5	chr20	53266953	+
Frame-shift	ENST00000377908	ENST00000262593	DIAPH3	chr13	60582677	-	DOK5	chr20	53266953	+
Frame-shift	ENST00000400319	ENST00000262593	DIAPH3	chr13	60582677	-	DOK5	chr20	53266953	+
Frame-shift	ENST00000400320	ENST00000262593	DIAPH3	chr13	60582677	-	DOK5	chr20	53266953	+
Frame-shift	ENST00000400324	ENST00000262593	DIAPH3	chr13	60582677	-	DOK5	chr20	53266953	+
Frame-shift	ENST00000400330	ENST00000262593	DIAPH3	chr13	60582677	-	DOK5	chr20	53266953	+
In-frame	ENST00000267215	ENST00000395939	DIAPH3	chr13	60582677	-	DOK5	chr20	53266953	+
In-frame	ENST00000377908	ENST00000395939	DIAPH3	chr13	60582677	-	DOK5	chr20	53266953	+
In-frame	ENST00000400319	ENST00000395939	DIAPH3	chr13	60582677	-	DOK5	chr20	53266953	+
In-frame	ENST00000400320	ENST00000395939	DIAPH3	chr13	60582677	-	DOK5	chr20	53266953	+
In-frame	ENST00000400324	ENST00000395939	DIAPH3	chr13	60582677	-	DOK5	chr20	53266953	+
In-frame	ENST00000400330	ENST00000395939	DIAPH3	chr13	60582677	-	DOK5	chr20	53266953	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000400324	DIAPH3	chr13	60582677	-	ENST00000395939	DOK5	chr20	53266953	+	1711	1235	110	1252	380
ENST00000400330	DIAPH3	chr13	60582677	-	ENST00000395939	DOK5	chr20	53266953	+	1709	1233	108	1250	380
ENST00000400319	DIAPH3	chr13	60582677	-	ENST00000395939	DOK5	chr20	53266953	+	1280	804	0	821	273
ENST00000400320	DIAPH3	chr13	60582677	-	ENST00000395939	DOK5	chr20	53266953	+	1352	876	0	893	297
ENST00000377908	DIAPH3	chr13	60582677	-	ENST00000395939	DOK5	chr20	53266953	+	1457	981	0	998	332
ENST00000267215	DIAPH3	chr13	60582677	-	ENST00000395939	DOK5	chr20	53266953	+	1490	1014	0	1031	343

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000400324	ENST00000395939	DIAPH3	chr13	60582677	-	DOK5	chr20	53266953	+	0.000500145	0.9994998
ENST00000400330	ENST00000395939	DIAPH3	chr13	60582677	-	DOK5	chr20	53266953	+	0.000508233	0.9994917
ENST00000400319	ENST00000395939	DIAPH3	chr13	60582677	-	DOK5	chr20	53266953	+	0.000490045	0.99950993
ENST00000400320	ENST00000395939	DIAPH3	chr13	60582677	-	DOK5	chr20	53266953	+	0.002438845	0.9975611
ENST00000377908	ENST00000395939	DIAPH3	chr13	60582677	-	DOK5	chr20	53266953	+	0.000569891	0.9994301
ENST00000267215	ENST00000395939	DIAPH3	chr13	60582677	-	DOK5	chr20	53266953	+	0.000428373	0.9995716

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Fusion Genomic Features for DIAPH3-DOK5

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
DIAPH3	chr13	60582677	-	DOK5	chr20	53266953	+	4.48E-07	0.9999995
DIAPH3	chr13	60582677	-	DOK5	chr20	53266953	+	4.48E-07	0.9999995

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DIAPH3-DOK5

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:60582677/chr20:53266953)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000267215

36_60

338

1113.0

Motif

Nuclear localization signal

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000377908

36_60

327

1183.0

Motif

Nuclear localization signal

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000400319

36_60

268

1124.0

Motif

Nuclear localization signal

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000400320

36_60

292

1148.0

Motif

Nuclear localization signal

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000400324

36_60

338

1194.0

Motif

Nuclear localization signal

Tgene

DOK5

chr13:60582677

chr20:53266953

ENST00000395939

263_273

177

199.0

Motif

Note=DKFBH motif

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000267215

1013_1056

338

1113.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000267215

497_554

338

1113.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000377908

1013_1056

327

1183.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000377908

497_554

327

1183.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000400319

1013_1056

268

1124.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000400319

497_554

268

1124.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000400320

1013_1056

292

1148.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000400320

497_554

292

1148.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000400324

1013_1056

338

1194.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000400324

497_554

338

1194.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000267215

561_636

338

1113.0

Compositional bias

Note=Pro-rich

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000377908

561_636

327

1183.0

Compositional bias

Note=Pro-rich

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000400319

561_636

268

1124.0

Compositional bias

Note=Pro-rich

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000400320

561_636

292

1148.0

Compositional bias

Note=Pro-rich

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000400324

561_636

338

1194.0

Compositional bias

Note=Pro-rich

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000267215

1057_1087

338

1113.0

Domain

DAD

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000267215

114_476

338

1113.0

Domain

GBD/FH3

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000267215

561_631

338

1113.0

Domain

Note=FH1

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000267215

636_1034

338

1113.0

Domain

FH2

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000377908

1057_1087

327

1183.0

Domain

DAD

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000377908

114_476

327

1183.0

Domain

GBD/FH3

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000377908

561_631

327

1183.0

Domain

Note=FH1

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000377908

636_1034

327

1183.0

Domain

FH2

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000400319

1057_1087

268

1124.0

Domain

DAD

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000400319

114_476

268

1124.0

Domain

GBD/FH3

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000400319

561_631

268

1124.0

Domain

Note=FH1

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000400319

636_1034

268

1124.0

Domain

FH2

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000400320

1057_1087

292

1148.0

Domain

DAD

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000400320

114_476

292

1148.0

Domain

GBD/FH3

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000400320

561_631

292

1148.0

Domain

Note=FH1

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000400320

636_1034

292

1148.0

Domain

FH2

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000400324

1057_1087

338

1194.0

Domain

DAD

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000400324

114_476

338

1194.0

Domain

GBD/FH3

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000400324

561_631

338

1194.0

Domain

Note=FH1

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000400324

636_1034

338

1194.0

Domain

FH2

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000267215

1184_1193

338

1113.0

Motif

Nuclear export signal

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000377908

1184_1193

327

1183.0

Motif

Nuclear export signal

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000400319

1184_1193

268

1124.0

Motif

Nuclear export signal

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000400320

1184_1193

292

1148.0

Motif

Nuclear export signal

Hgene

DIAPH3

chr13:60582677

chr20:53266953

ENST00000400324

1184_1193

338

1194.0

Motif

Nuclear export signal

Tgene

DOK5

chr13:60582677

chr20:53266953

ENST00000262593

132_237

285

307.0

Domain

IRS-type PTB

Tgene

DOK5

chr13:60582677

chr20:53266953

ENST00000262593

8_112

285

307.0

Domain

Note=PH

Tgene

DOK5

chr13:60582677

chr20:53266953

ENST00000395939

132_237

177

199.0

Domain

IRS-type PTB

Tgene

DOK5

chr13:60582677

chr20:53266953

ENST00000395939

8_112

177

199.0

Domain

Note=PH

Tgene

DOK5

chr13:60582677

chr20:53266953

ENST00000262593

263_273

285

307.0

Motif

Note=DKFBH motif

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Fusion Gene Sequence for DIAPH3-DOK5

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>22769_22769_1_DIAPH3-DOK5_DIAPH3_chr13_60582677_ENST00000267215_DOK5_chr20_53266953_ENST00000395939_length(transcript)=1490nt_BP=1014nt
ATGGAACGGCACCAGCCGCGGCTGCACCACCCGGCCCAAGGCTCAGCCGCTGGGACTCCCTACCCTTCCTCAGCCTCTCTCCGCGGCTGC
CGGGAAAGCAAGATGCCGCGCAGGAAGGGCCCCCAACACCCTCCGCCGCCCAGTGGCCCCGAGGAGCCTGGGGAGAAGCGCCCCAAGTTT
CATTTAAATATTAGGACACTGACGGATGATATGCTGGACAAATTTGCCAGCATAAGAATTCCAGGGAGCAAGAAAGAGAGACCTCCACTT
CCCAACCTGAAGACTGCATTTGCAAGCAGTGATTGCTCAGCAGCACCTTTAGAGATGATGGAGAACTTTCCAAAGCCACTGTCAGAGAAT
GAACTCTTAGAACTTTTTGAAAAAATGATGGAAGATATGAATTTAAATGAAGATAAAAAGGCACCATTGCGGGAAAAGGACTTCAGTATC
AAAAAAGAAATGGTGATGCAGTACATTAATACTGCTTCTAAGACAGGAAGTCTTAAGAGAAGCCGACAGATCTCACCTCAGGAATTCATT
CATGAGCTGAAAATGGGGTCTGCAGATGAGAGACTTGTCACATGCCTGGAGTCTCTCCGAGTGTCTTTGACCAGCAATCCTGTGAGTTGG
GTGGAAAGCTTTGGACATGAAGGGCTTGGATTATTATTAGACATTTTGGAAAAACTGATTAGTGGAAAAATCCAAGAAAAAGTTGTAAAG
AAAAATCAACATAAAGTCATACAGTGTCTAAAAGCCCTGATGAATACGCAGTATGGCTTGGAAAGAATTATGAGTGAGGAGAGGAGCCTT
TCCTTATTGGCCAAAGCCGTGGATCCCAGACACCCCAATATGATGACAGATGTGGTTAAACTTCTCTCTGCGGTATGCATTGTAGGGGAA
GAAAGCATCCTTGAAGAAGTTTTAGAAGCTTTAACTTCAGCTGGTGAAGAAAAAAAAATTGACAGATTTTTTTGTATTGTGGAAGGCCTC
CGGCACAATTCAGTTCAACTGCAAATGTTTCCAGCCCTCTGAAGCTTCATCGAACAGAGACTTTTCCAGCCTACAGATCTGAGCACTGAC
AGTAACTGCCAAGAATTGTTAACACACTTGTGATGTGTCAGCCACAGATTCACCCAGGAGGTCACAGAATGACAGCAAGGGAAATGACGA
CCAAGAGAAGAAGCTTAAAGTCCTGGCTAATTGTGTGGTCATTGGAAAACTCTGCAATACAATAATTTTCTTTATTTTCTTTTTCTTTTT
TAAATTCTTAGTGTAATTGAAACGTGCTCTATAGATATTGACTCTGTGTTCCCTCTTTTACAGCTGGACAGAAAGAAGTCAATGTCACGA
AATGATTTTCTATTGTAGATACTTTGTCCCTTGCACTTCTCTGAATCTGTCCTTTTGTGGATTCTTGTGATTTTCCTTCCAAGTGTTTCA
GTTGTATGACAGTCAGTATTGACAATAAAATGGCTTTTAATTATTTGTTA

>22769_22769_1_DIAPH3-DOK5_DIAPH3_chr13_60582677_ENST00000267215_DOK5_chr20_53266953_ENST00000395939_length(amino acids)=343AA_BP=
MERHQPRLHHPAQGSAAGTPYPSSASLRGCRESKMPRRKGPQHPPPPSGPEEPGEKRPKFHLNIRTLTDDMLDKFASIRIPGSKKERPPL
PNLKTAFASSDCSAAPLEMMENFPKPLSENELLELFEKMMEDMNLNEDKKAPLREKDFSIKKEMVMQYINTASKTGSLKRSRQISPQEFI
HELKMGSADERLVTCLESLRVSLTSNPVSWVESFGHEGLGLLLDILEKLISGKIQEKVVKKNQHKVIQCLKALMNTQYGLERIMSEERSL
SLLAKAVDPRHPNMMTDVVKLLSAVCIVGEESILEEVLEALTSAGEEKKIDRFFCIVEGLRHNSVQLQMFPAL

--------------------------------------------------------------
>22769_22769_2_DIAPH3-DOK5_DIAPH3_chr13_60582677_ENST00000377908_DOK5_chr20_53266953_ENST00000395939_length(transcript)=1457nt_BP=981nt
ATGGAACGGCACCAGCCGCGGCTGCACCACCCGGCCCAAGGCTCAGCCGCTGGGACTCCCTACCCTTCCTCAGCCTCTCTCCGCGGCTGC
CGGGAAAGCAAGATGCCGCGCAGGAAGGGCCCCCAACACCCTCCGCCGCCCAGTGGCCCCGAGGAGCCTGGGGAGAAGCGCCCCAAGTTT
CTGGACAAATTTGCCAGCATAAGAATTCCAGGGAGCAAGAAAGAGAGACCTCCACTTCCCAACCTGAAGACTGCATTTGCAAGCAGTGAT
TGCTCAGCAGCACCTTTAGAGATGATGGAGAACTTTCCAAAGCCACTGTCAGAGAATGAACTCTTAGAACTTTTTGAAAAAATGATGGAA
GATATGAATTTAAATGAAGATAAAAAGGCACCATTGCGGGAAAAGGACTTCAGTATCAAAAAAGAAATGGTGATGCAGTACATTAATACT
GCTTCTAAGACAGGAAGTCTTAAGAGAAGCCGACAGATCTCACCTCAGGAATTCATTCATGAGCTGAAAATGGGGTCTGCAGATGAGAGA
CTTGTCACATGCCTGGAGTCTCTCCGAGTGTCTTTGACCAGCAATCCTGTGAGTTGGGTGGAAAGCTTTGGACATGAAGGGCTTGGATTA
TTATTAGACATTTTGGAAAAACTGATTAGTGGAAAAATCCAAGAAAAAGTTGTAAAGAAAAATCAACATAAAGTCATACAGTGTCTAAAA
GCCCTGATGAATACGCAGTATGGCTTGGAAAGAATTATGAGTGAGGAGAGGAGCCTTTCCTTATTGGCCAAAGCCGTGGATCCCAGACAC
CCCAATATGATGACAGATGTGGTTAAACTTCTCTCTGCGGTATGCATTGTAGGGGAAGAAAGCATCCTTGAAGAAGTTTTAGAAGCTTTA
ACTTCAGCTGGTGAAGAAAAAAAAATTGACAGATTTTTTTGTATTGTGGAAGGCCTCCGGCACAATTCAGTTCAACTGCAAATGTTTCCA
GCCCTCTGAAGCTTCATCGAACAGAGACTTTTCCAGCCTACAGATCTGAGCACTGACAGTAACTGCCAAGAATTGTTAACACACTTGTGA
TGTGTCAGCCACAGATTCACCCAGGAGGTCACAGAATGACAGCAAGGGAAATGACGACCAAGAGAAGAAGCTTAAAGTCCTGGCTAATTG
TGTGGTCATTGGAAAACTCTGCAATACAATAATTTTCTTTATTTTCTTTTTCTTTTTTAAATTCTTAGTGTAATTGAAACGTGCTCTATA
GATATTGACTCTGTGTTCCCTCTTTTACAGCTGGACAGAAAGAAGTCAATGTCACGAAATGATTTTCTATTGTAGATACTTTGTCCCTTG
CACTTCTCTGAATCTGTCCTTTTGTGGATTCTTGTGATTTTCCTTCCAAGTGTTTCAGTTGTATGACAGTCAGTATTGACAATAAAATGG
CTTTTAATTATTTGTTA

>22769_22769_2_DIAPH3-DOK5_DIAPH3_chr13_60582677_ENST00000377908_DOK5_chr20_53266953_ENST00000395939_length(amino acids)=332AA_BP=
MERHQPRLHHPAQGSAAGTPYPSSASLRGCRESKMPRRKGPQHPPPPSGPEEPGEKRPKFLDKFASIRIPGSKKERPPLPNLKTAFASSD
CSAAPLEMMENFPKPLSENELLELFEKMMEDMNLNEDKKAPLREKDFSIKKEMVMQYINTASKTGSLKRSRQISPQEFIHELKMGSADER
LVTCLESLRVSLTSNPVSWVESFGHEGLGLLLDILEKLISGKIQEKVVKKNQHKVIQCLKALMNTQYGLERIMSEERSLSLLAKAVDPRH
PNMMTDVVKLLSAVCIVGEESILEEVLEALTSAGEEKKIDRFFCIVEGLRHNSVQLQMFPAL

--------------------------------------------------------------
>22769_22769_3_DIAPH3-DOK5_DIAPH3_chr13_60582677_ENST00000400319_DOK5_chr20_53266953_ENST00000395939_length(transcript)=1280nt_BP=804nt
ATGGAACGGCACCAGCCGCGGCTGCACCACCCGGCCCAAGGCTCAGCCGCTGGGACTCCCTACCCTTCCTCAGCCTCTCTCCGCGGCTGC
CGGGAAAGCAAGATGCCGCGCAGGAAGGGCCCCCAACACCCTCCGCCGCCCAGTGGCCCCGAGGAGCCTGGGGAGAAGCGCCCCAAGTTT
GAAGATATGAATTTAAATGAAGATAAAAAGGCACCATTGCGGGAAAAGGACTTCAGTATCAAAAAAGAAATGGTGATGCAGTACATTAAT
ACTGCTTCTAAGACAGGAAGTCTTAAGAGAAGCCGACAGATCTCACCTCAGGAATTCATTCATGAGCTGAAAATGGGGTCTGCAGATGAG
AGACTTGTCACATGCCTGGAGTCTCTCCGAGTGTCTTTGACCAGCAATCCTGTGAGTTGGGTGGAAAGCTTTGGACATGAAGGGCTTGGA
TTATTATTAGACATTTTGGAAAAACTGATTAGTGGAAAAATCCAAGAAAAAGTTGTAAAGAAAAATCAACATAAAGTCATACAGTGTCTA
AAAGCCCTGATGAATACGCAGTATGGCTTGGAAAGAATTATGAGTGAGGAGAGGAGCCTTTCCTTATTGGCCAAAGCCGTGGATCCCAGA
CACCCCAATATGATGACAGATGTGGTTAAACTTCTCTCTGCGGTATGCATTGTAGGGGAAGAAAGCATCCTTGAAGAAGTTTTAGAAGCT
TTAACTTCAGCTGGTGAAGAAAAAAAAATTGACAGATTTTTTTGTATTGTGGAAGGCCTCCGGCACAATTCAGTTCAACTGCAAATGTTT
CCAGCCCTCTGAAGCTTCATCGAACAGAGACTTTTCCAGCCTACAGATCTGAGCACTGACAGTAACTGCCAAGAATTGTTAACACACTTG
TGATGTGTCAGCCACAGATTCACCCAGGAGGTCACAGAATGACAGCAAGGGAAATGACGACCAAGAGAAGAAGCTTAAAGTCCTGGCTAA
TTGTGTGGTCATTGGAAAACTCTGCAATACAATAATTTTCTTTATTTTCTTTTTCTTTTTTAAATTCTTAGTGTAATTGAAACGTGCTCT
ATAGATATTGACTCTGTGTTCCCTCTTTTACAGCTGGACAGAAAGAAGTCAATGTCACGAAATGATTTTCTATTGTAGATACTTTGTCCC
TTGCACTTCTCTGAATCTGTCCTTTTGTGGATTCTTGTGATTTTCCTTCCAAGTGTTTCAGTTGTATGACAGTCAGTATTGACAATAAAA
TGGCTTTTAATTATTTGTTA

>22769_22769_3_DIAPH3-DOK5_DIAPH3_chr13_60582677_ENST00000400319_DOK5_chr20_53266953_ENST00000395939_length(amino acids)=273AA_BP=
MERHQPRLHHPAQGSAAGTPYPSSASLRGCRESKMPRRKGPQHPPPPSGPEEPGEKRPKFEDMNLNEDKKAPLREKDFSIKKEMVMQYIN
TASKTGSLKRSRQISPQEFIHELKMGSADERLVTCLESLRVSLTSNPVSWVESFGHEGLGLLLDILEKLISGKIQEKVVKKNQHKVIQCL
KALMNTQYGLERIMSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGEESILEEVLEALTSAGEEKKIDRFFCIVEGLRHNSVQLQMF
PAL

--------------------------------------------------------------
>22769_22769_4_DIAPH3-DOK5_DIAPH3_chr13_60582677_ENST00000400320_DOK5_chr20_53266953_ENST00000395939_length(transcript)=1352nt_BP=876nt
ATGGAACGGCACCAGCCGCGGCTGCACCACCCGGCCCAAGGCTCAGCCGCTGGGACTCCCTACCCTTCCTCAGCCTCTCTCCGCGGCTGC
CGGGAAAGCAAGATGCCGCGCAGGAAGGGCCCCCAACACCCTCCGCCGCCCAGTGGCCCCGAGGAGCCTGGGGAGAAGCGCCCCAAGTTT
CTGGACAAATTTGCCAGCATAAGAATTCCAGGGAGCAAGAAAGAGAGACCTCCACTTCCCAACCTGAAGACTGCATTTGCAAGCAGTGAT
TGCTCAGCAGCACCTTTAGAGATGATGGAGAACTTTCCAAAGCCACTGTCAGAGAATGAACTCTTAGAACTTTTTGAAAAAATGATGGGA
AGTCTTAAGAGAAGCCGACAGATCTCACCTCAGGAATTCATTCATGAGCTGAAAATGGGGTCTGCAGATGAGAGACTTGTCACATGCCTG
GAGTCTCTCCGAGTGTCTTTGACCAGCAATCCTGTGAGTTGGGTGGAAAGCTTTGGACATGAAGGGCTTGGATTATTATTAGACATTTTG
GAAAAACTGATTAGTGGAAAAATCCAAGAAAAAGTTGTAAAGAAAAATCAACATAAAGTCATACAGTGTCTAAAAGCCCTGATGAATACG
CAGTATGGCTTGGAAAGAATTATGAGTGAGGAGAGGAGCCTTTCCTTATTGGCCAAAGCCGTGGATCCCAGACACCCCAATATGATGACA
GATGTGGTTAAACTTCTCTCTGCGGTATGCATTGTAGGGGAAGAAAGCATCCTTGAAGAAGTTTTAGAAGCTTTAACTTCAGCTGGTGAA
GAAAAAAAAATTGACAGATTTTTTTGTATTGTGGAAGGCCTCCGGCACAATTCAGTTCAACTGCAAATGTTTCCAGCCCTCTGAAGCTTC
ATCGAACAGAGACTTTTCCAGCCTACAGATCTGAGCACTGACAGTAACTGCCAAGAATTGTTAACACACTTGTGATGTGTCAGCCACAGA
TTCACCCAGGAGGTCACAGAATGACAGCAAGGGAAATGACGACCAAGAGAAGAAGCTTAAAGTCCTGGCTAATTGTGTGGTCATTGGAAA
ACTCTGCAATACAATAATTTTCTTTATTTTCTTTTTCTTTTTTAAATTCTTAGTGTAATTGAAACGTGCTCTATAGATATTGACTCTGTG
TTCCCTCTTTTACAGCTGGACAGAAAGAAGTCAATGTCACGAAATGATTTTCTATTGTAGATACTTTGTCCCTTGCACTTCTCTGAATCT
GTCCTTTTGTGGATTCTTGTGATTTTCCTTCCAAGTGTTTCAGTTGTATGACAGTCAGTATTGACAATAAAATGGCTTTTAATTATTTGT
TA

>22769_22769_4_DIAPH3-DOK5_DIAPH3_chr13_60582677_ENST00000400320_DOK5_chr20_53266953_ENST00000395939_length(amino acids)=297AA_BP=
MERHQPRLHHPAQGSAAGTPYPSSASLRGCRESKMPRRKGPQHPPPPSGPEEPGEKRPKFLDKFASIRIPGSKKERPPLPNLKTAFASSD
CSAAPLEMMENFPKPLSENELLELFEKMMGSLKRSRQISPQEFIHELKMGSADERLVTCLESLRVSLTSNPVSWVESFGHEGLGLLLDIL
EKLISGKIQEKVVKKNQHKVIQCLKALMNTQYGLERIMSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGEESILEEVLEALTSAGE
EKKIDRFFCIVEGLRHNSVQLQMFPAL

--------------------------------------------------------------
>22769_22769_5_DIAPH3-DOK5_DIAPH3_chr13_60582677_ENST00000400324_DOK5_chr20_53266953_ENST00000395939_length(transcript)=1711nt_BP=1235nt
ATTGATCCGGCGGCGCGGGATTGGCCAGTCCCGGGCCAACACGGGTGGCGGGAGTTTTCAGATGTGTTGGCTGCGGCCCCGACTTCAGCG
GTTGGGCTAGGCTGTGCTGACTGTTTGGGTGGCGGACCCCGGGAGTAAAACCTGTTGTCGATCCCTCAGCTTCCAGCTTGCGGCTTGCTG
AGTGGCCACCTTCTTTCCGGTCCCCGGAGCTGCGGGGAAAGATGGAACGGCACCAGCCGCGGCTGCACCACCCGGCCCAAGGCTCAGCCG
CTGGGACTCCCTACCCTTCCTCAGCCTCTCTCCGCGGCTGCCGGGAAAGCAAGATGCCGCGCAGGAAGGGCCCCCAACACCCTCCGCCGC
CCAGTGGCCCCGAGGAGCCTGGGGAGAAGCGCCCCAAGTTTCATTTAAATATTAGGACACTGACGGATGATATGCTGGACAAATTTGCCA
GCATAAGAATTCCAGGGAGCAAGAAAGAGAGACCTCCACTTCCCAACCTGAAGACTGCATTTGCAAGCAGTGATTGCTCAGCAGCACCTT
TAGAGATGATGGAGAACTTTCCAAAGCCACTGTCAGAGAATGAACTCTTAGAACTTTTTGAAAAAATGATGGAAGATATGAATTTAAATG
AAGATAAAAAGGCACCATTGCGGGAAAAGGACTTCAGTATCAAAAAAGAAATGGTGATGCAGTACATTAATACTGCTTCTAAGACAGGAA
GTCTTAAGAGAAGCCGACAGATCTCACCTCAGGAATTCATTCATGAGCTGAAAATGGGGTCTGCAGATGAGAGACTTGTCACATGCCTGG
AGTCTCTCCGAGTGTCTTTGACCAGCAATCCTGTGAGTTGGGTGGAAAGCTTTGGACATGAAGGGCTTGGATTATTATTAGACATTTTGG
AAAAACTGATTAGTGGAAAAATCCAAGAAAAAGTTGTAAAGAAAAATCAACATAAAGTCATACAGTGTCTAAAAGCCCTGATGAATACGC
AGTATGGCTTGGAAAGAATTATGAGTGAGGAGAGGAGCCTTTCCTTATTGGCCAAAGCCGTGGATCCCAGACACCCCAATATGATGACAG
ATGTGGTTAAACTTCTCTCTGCGGTATGCATTGTAGGGGAAGAAAGCATCCTTGAAGAAGTTTTAGAAGCTTTAACTTCAGCTGGTGAAG
AAAAAAAAATTGACAGATTTTTTTGTATTGTGGAAGGCCTCCGGCACAATTCAGTTCAACTGCAAATGTTTCCAGCCCTCTGAAGCTTCA
TCGAACAGAGACTTTTCCAGCCTACAGATCTGAGCACTGACAGTAACTGCCAAGAATTGTTAACACACTTGTGATGTGTCAGCCACAGAT
TCACCCAGGAGGTCACAGAATGACAGCAAGGGAAATGACGACCAAGAGAAGAAGCTTAAAGTCCTGGCTAATTGTGTGGTCATTGGAAAA
CTCTGCAATACAATAATTTTCTTTATTTTCTTTTTCTTTTTTAAATTCTTAGTGTAATTGAAACGTGCTCTATAGATATTGACTCTGTGT
TCCCTCTTTTACAGCTGGACAGAAAGAAGTCAATGTCACGAAATGATTTTCTATTGTAGATACTTTGTCCCTTGCACTTCTCTGAATCTG
TCCTTTTGTGGATTCTTGTGATTTTCCTTCCAAGTGTTTCAGTTGTATGACAGTCAGTATTGACAATAAAATGGCTTTTAATTATTTGTT
A

>22769_22769_5_DIAPH3-DOK5_DIAPH3_chr13_60582677_ENST00000400324_DOK5_chr20_53266953_ENST00000395939_length(amino acids)=380AA_BP=
MFGWRTPGVKPVVDPSASSLRLAEWPPSFRSPELRGKMERHQPRLHHPAQGSAAGTPYPSSASLRGCRESKMPRRKGPQHPPPPSGPEEP
GEKRPKFHLNIRTLTDDMLDKFASIRIPGSKKERPPLPNLKTAFASSDCSAAPLEMMENFPKPLSENELLELFEKMMEDMNLNEDKKAPL
REKDFSIKKEMVMQYINTASKTGSLKRSRQISPQEFIHELKMGSADERLVTCLESLRVSLTSNPVSWVESFGHEGLGLLLDILEKLISGK
IQEKVVKKNQHKVIQCLKALMNTQYGLERIMSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGEESILEEVLEALTSAGEEKKIDRF
FCIVEGLRHNSVQLQMFPAL

--------------------------------------------------------------
>22769_22769_6_DIAPH3-DOK5_DIAPH3_chr13_60582677_ENST00000400330_DOK5_chr20_53266953_ENST00000395939_length(transcript)=1709nt_BP=1233nt
TGATCCGGCGGCGCGGGATTGGCCAGTCCCGGGCCAACACGGGTGGCGGGAGTTTTCAGATGTGTTGGCTGCGGCCCCGACTTCAGCGGT
TGGGCTAGGCTGTGCTGACTGTTTGGGTGGCGGACCCCGGGAGTAAAACCTGTTGTCGATCCCTCAGCTTCCAGCTTGCGGCTTGCTGAG
TGGCCACCTTCTTTCCGGTCCCCGGAGCTGCGGGGAAAGATGGAACGGCACCAGCCGCGGCTGCACCACCCGGCCCAAGGCTCAGCCGCT
GGGACTCCCTACCCTTCCTCAGCCTCTCTCCGCGGCTGCCGGGAAAGCAAGATGCCGCGCAGGAAGGGCCCCCAACACCCTCCGCCGCCC
AGTGGCCCCGAGGAGCCTGGGGAGAAGCGCCCCAAGTTTCATTTAAATATTAGGACACTGACGGATGATATGCTGGACAAATTTGCCAGC
ATAAGAATTCCAGGGAGCAAGAAAGAGAGACCTCCACTTCCCAACCTGAAGACTGCATTTGCAAGCAGTGATTGCTCAGCAGCACCTTTA
GAGATGATGGAGAACTTTCCAAAGCCACTGTCAGAGAATGAACTCTTAGAACTTTTTGAAAAAATGATGGAAGATATGAATTTAAATGAA
GATAAAAAGGCACCATTGCGGGAAAAGGACTTCAGTATCAAAAAAGAAATGGTGATGCAGTACATTAATACTGCTTCTAAGACAGGAAGT
CTTAAGAGAAGCCGACAGATCTCACCTCAGGAATTCATTCATGAGCTGAAAATGGGGTCTGCAGATGAGAGACTTGTCACATGCCTGGAG
TCTCTCCGAGTGTCTTTGACCAGCAATCCTGTGAGTTGGGTGGAAAGCTTTGGACATGAAGGGCTTGGATTATTATTAGACATTTTGGAA
AAACTGATTAGTGGAAAAATCCAAGAAAAAGTTGTAAAGAAAAATCAACATAAAGTCATACAGTGTCTAAAAGCCCTGATGAATACGCAG
TATGGCTTGGAAAGAATTATGAGTGAGGAGAGGAGCCTTTCCTTATTGGCCAAAGCCGTGGATCCCAGACACCCCAATATGATGACAGAT
GTGGTTAAACTTCTCTCTGCGGTATGCATTGTAGGGGAAGAAAGCATCCTTGAAGAAGTTTTAGAAGCTTTAACTTCAGCTGGTGAAGAA
AAAAAAATTGACAGATTTTTTTGTATTGTGGAAGGCCTCCGGCACAATTCAGTTCAACTGCAAATGTTTCCAGCCCTCTGAAGCTTCATC
GAACAGAGACTTTTCCAGCCTACAGATCTGAGCACTGACAGTAACTGCCAAGAATTGTTAACACACTTGTGATGTGTCAGCCACAGATTC
ACCCAGGAGGTCACAGAATGACAGCAAGGGAAATGACGACCAAGAGAAGAAGCTTAAAGTCCTGGCTAATTGTGTGGTCATTGGAAAACT
CTGCAATACAATAATTTTCTTTATTTTCTTTTTCTTTTTTAAATTCTTAGTGTAATTGAAACGTGCTCTATAGATATTGACTCTGTGTTC
CCTCTTTTACAGCTGGACAGAAAGAAGTCAATGTCACGAAATGATTTTCTATTGTAGATACTTTGTCCCTTGCACTTCTCTGAATCTGTC
CTTTTGTGGATTCTTGTGATTTTCCTTCCAAGTGTTTCAGTTGTATGACAGTCAGTATTGACAATAAAATGGCTTTTAATTATTTGTTA

>22769_22769_6_DIAPH3-DOK5_DIAPH3_chr13_60582677_ENST00000400330_DOK5_chr20_53266953_ENST00000395939_length(amino acids)=380AA_BP=
MFGWRTPGVKPVVDPSASSLRLAEWPPSFRSPELRGKMERHQPRLHHPAQGSAAGTPYPSSASLRGCRESKMPRRKGPQHPPPPSGPEEP
GEKRPKFHLNIRTLTDDMLDKFASIRIPGSKKERPPLPNLKTAFASSDCSAAPLEMMENFPKPLSENELLELFEKMMEDMNLNEDKKAPL
REKDFSIKKEMVMQYINTASKTGSLKRSRQISPQEFIHELKMGSADERLVTCLESLRVSLTSNPVSWVESFGHEGLGLLLDILEKLISGK
IQEKVVKKNQHKVIQCLKALMNTQYGLERIMSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGEESILEEVLEALTSAGEEKKIDRF
FCIVEGLRHNSVQLQMFPAL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for DIAPH3-DOK5

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for DIAPH3-DOK5

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for DIAPH3-DOK5

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	DIAPH3	C1852271	Auditory neuropathy	2	CLINGEN
Hgene	DIAPH3	C2732267	Auditory neuropathy spectrum disorder	2	CLINGEN
Hgene	DIAPH3	C1836743	AUDITORY NEUROPATHY, AUTOSOMAL DOMINANT, 1	1	CTD_human;GENOMICS_ENGLAND
Tgene		C0005586	Bipolar Disorder	1	PSYGENET

Fusion Gene Studies in Kim Lab

Fusion gene:DIAPH3-DOK5 (FusionGDB2 ID:HG81624TG55816)

Fusion Gene Summary for DIAPH3-DOK5

Fusion Gene ORF analysis for DIAPH3-DOK5

Fusion Genomic Features for DIAPH3-DOK5

Fusion Protein Features for DIAPH3-DOK5

Fusion Gene Sequence for DIAPH3-DOK5

Fusion Gene PPI Analysis for DIAPH3-DOK5

Related Drugs for DIAPH3-DOK5

Related Diseases for DIAPH3-DOK5

Fusion Gene Studies
in Kim Lab