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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ADAMTS12-C1QTNF3 (FusionGDB2 ID:HG81792TG114899)

Fusion Gene Summary for ADAMTS12-C1QTNF3

check button Fusion gene summary
Fusion gene informationFusion gene name: ADAMTS12-C1QTNF3
Fusion gene ID: hg81792tg114899
HgeneTgene
Gene symbol

ADAMTS12

C1QTNF3

Gene ID

81792

114899

Gene nameADAM metallopeptidase with thrombospondin type 1 motif 12C1q and TNF related 3
SynonymsPRO4389C1ATNF3|CORCS|CORS|CORS-26|CORS26|CTRP3
Cytomap('ADAMTS12')('C1QTNF3')

5p13.3-p13.2

5p13.2

Type of geneprotein-codingprotein-coding
DescriptionA disintegrin and metalloproteinase with thrombospondin motifs 12ADAM-TS 12ADAM-TS12ADAMTS-12a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12complement C1q tumor necrosis factor-related protein 3C1q and tumor necrosis factor related protein 3cartonectincollagenous repeat-containing sequence 26 kDa proteincollagenous repeat-containing sequence of 26-kDasecretory protein CORS26
Modification date2020031320200322
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000352040, ENST00000504830, 
ENST00000515401, ENST00000504582, 
Fusion gene scores* DoF score6 X 6 X 4=1447 X 3 X 6=126
# samples 68
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/126*10)=-0.655351828612554
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADAMTS12 [Title/Abstract] AND C1QTNF3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointADAMTS12(33891835)-C1QTNF3(34035863), # samples:1
Anticipated loss of major functional domain due to fusion event.ADAMTS12-C1QTNF3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADAMTS12-C1QTNF3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADAMTS12-C1QTNF3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ADAMTS12-C1QTNF3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneADAMTS12

GO:0030167

proteoglycan catabolic process

17895370

HgeneADAMTS12

GO:0032331

negative regulation of chondrocyte differentiation

22247065

HgeneADAMTS12

GO:0050727

regulation of inflammatory response

23019333

HgeneADAMTS12

GO:0051603

proteolysis involved in cellular protein catabolic process

16611630

HgeneADAMTS12

GO:0071773

cellular response to BMP stimulus

22247065

HgeneADAMTS12

GO:1901509

regulation of endothelial tube morphogenesis

17895370

HgeneADAMTS12

GO:1902203

negative regulation of hepatocyte growth factor receptor signaling pathway

17895370

HgeneADAMTS12

GO:1902548

negative regulation of cellular response to vascular endothelial growth factor stimulus

17895370

HgeneADAMTS12

GO:2001113

negative regulation of cellular response to hepatocyte growth factor stimulus

17895370

TgeneC1QTNF3

GO:0035356

cellular triglyceride homeostasis

20739398

TgeneC1QTNF3

GO:0045721

negative regulation of gluconeogenesis

20952387

TgeneC1QTNF3

GO:0050715

positive regulation of cytokine secretion

18421280

TgeneC1QTNF3

GO:0050728

negative regulation of inflammatory response

16213490

TgeneC1QTNF3

GO:0070165

positive regulation of adiponectin secretion

18421280

TgeneC1QTNF3

GO:0071638

negative regulation of monocyte chemotactic protein-1 production

20739398

TgeneC1QTNF3

GO:1900165

negative regulation of interleukin-6 secretion

16213490

TgeneC1QTNF3

GO:1901223

negative regulation of NIK/NF-kappaB signaling

16213490


check buttonFusion gene breakpoints across ADAMTS12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across C1QTNF3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AN-A0AR-01AADAMTS12chr5

33891835

-C1QTNF3chr5

34035863

-


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Fusion Gene ORF analysis for ADAMTS12-C1QTNF3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000352040ENST00000513065ADAMTS12chr5

33891835

-C1QTNF3chr5

34035863

-
5CDS-intronENST00000504830ENST00000513065ADAMTS12chr5

33891835

-C1QTNF3chr5

34035863

-
5CDS-intronENST00000515401ENST00000513065ADAMTS12chr5

33891835

-C1QTNF3chr5

34035863

-
In-frameENST00000352040ENST00000231338ADAMTS12chr5

33891835

-C1QTNF3chr5

34035863

-
In-frameENST00000352040ENST00000382065ADAMTS12chr5

33891835

-C1QTNF3chr5

34035863

-
In-frameENST00000504830ENST00000231338ADAMTS12chr5

33891835

-C1QTNF3chr5

34035863

-
In-frameENST00000504830ENST00000382065ADAMTS12chr5

33891835

-C1QTNF3chr5

34035863

-
In-frameENST00000515401ENST00000231338ADAMTS12chr5

33891835

-C1QTNF3chr5

34035863

-
In-frameENST00000515401ENST00000382065ADAMTS12chr5

33891835

-C1QTNF3chr5

34035863

-
intron-3CDSENST00000504582ENST00000231338ADAMTS12chr5

33891835

-C1QTNF3chr5

34035863

-
intron-3CDSENST00000504582ENST00000382065ADAMTS12chr5

33891835

-C1QTNF3chr5

34035863

-
intron-intronENST00000504582ENST00000513065ADAMTS12chr5

33891835

-C1QTNF3chr5

34035863

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000504830ADAMTS12chr533891835-ENST00000382065C1QTNF3chr534035863-22554633611119252
ENST00000504830ADAMTS12chr533891835-ENST00000231338C1QTNF3chr534035863-22504633611119252
ENST00000352040ADAMTS12chr533891835-ENST00000382065C1QTNF3chr534035863-2004212110868252
ENST00000352040ADAMTS12chr533891835-ENST00000231338C1QTNF3chr534035863-1999212110868252
ENST00000515401ADAMTS12chr533891835-ENST00000382065C1QTNF3chr534035863-2082290188946252
ENST00000515401ADAMTS12chr533891835-ENST00000231338C1QTNF3chr534035863-2077290188946252

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000504830ENST00000382065ADAMTS12chr533891835-C1QTNF3chr534035863-0.0012352430.99876475
ENST00000504830ENST00000231338ADAMTS12chr533891835-C1QTNF3chr534035863-0.0012410350.99875903
ENST00000352040ENST00000382065ADAMTS12chr533891835-C1QTNF3chr534035863-0.001027780.9989722
ENST00000352040ENST00000231338ADAMTS12chr533891835-C1QTNF3chr534035863-0.0010461530.9989538
ENST00000515401ENST00000382065ADAMTS12chr533891835-C1QTNF3chr534035863-0.0010181150.9989819
ENST00000515401ENST00000231338ADAMTS12chr533891835-C1QTNF3chr534035863-0.0010380270.9989619

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Fusion Genomic Features for ADAMTS12-C1QTNF3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ADAMTS12-C1QTNF3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:33891835/chr5:34035863)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneC1QTNF3chr5:33891835chr5:34035863ENST0000023133806113_24628247.0DomainC1q
TgeneC1QTNF3chr5:33891835chr5:34035863ENST000002313380651_11328247.0DomainNote=Collagen-like
TgeneC1QTNF3chr5:33891835chr5:34035863ENST0000038206506113_246101320.0DomainC1q

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADAMTS12chr5:33891835chr5:34035863ENST00000352040-122302_305421510.0Compositional biasNote=Poly-Glu
HgeneADAMTS12chr5:33891835chr5:34035863ENST00000352040-122597_700421510.0Compositional biasNote=Cys-rich
HgeneADAMTS12chr5:33891835chr5:34035863ENST00000504830-124302_305421595.0Compositional biasNote=Poly-Glu
HgeneADAMTS12chr5:33891835chr5:34035863ENST00000504830-124597_700421595.0Compositional biasNote=Cys-rich
HgeneADAMTS12chr5:33891835chr5:34035863ENST00000352040-1221313_1366421510.0DomainTSP type-1 5
HgeneADAMTS12chr5:33891835chr5:34035863ENST00000352040-1221368_1422421510.0DomainTSP type-1 6
HgeneADAMTS12chr5:33891835chr5:34035863ENST00000352040-1221423_1471421510.0DomainTSP type-1 7
HgeneADAMTS12chr5:33891835chr5:34035863ENST00000352040-1221472_1532421510.0DomainTSP type-1 8
HgeneADAMTS12chr5:33891835chr5:34035863ENST00000352040-1221535_1575421510.0DomainPLAC
HgeneADAMTS12chr5:33891835chr5:34035863ENST00000352040-122246_456421510.0DomainPeptidase M12B
HgeneADAMTS12chr5:33891835chr5:34035863ENST00000352040-122465_544421510.0DomainNote=Disintegrin
HgeneADAMTS12chr5:33891835chr5:34035863ENST00000352040-122542_597421510.0DomainTSP type-1 1
HgeneADAMTS12chr5:33891835chr5:34035863ENST00000352040-122823_883421510.0DomainTSP type-1 2
HgeneADAMTS12chr5:33891835chr5:34035863ENST00000352040-122887_943421510.0DomainTSP type-1 3
HgeneADAMTS12chr5:33891835chr5:34035863ENST00000352040-122944_997421510.0DomainTSP type-1 4
HgeneADAMTS12chr5:33891835chr5:34035863ENST00000504830-1241313_1366421595.0DomainTSP type-1 5
HgeneADAMTS12chr5:33891835chr5:34035863ENST00000504830-1241368_1422421595.0DomainTSP type-1 6
HgeneADAMTS12chr5:33891835chr5:34035863ENST00000504830-1241423_1471421595.0DomainTSP type-1 7
HgeneADAMTS12chr5:33891835chr5:34035863ENST00000504830-1241472_1532421595.0DomainTSP type-1 8
HgeneADAMTS12chr5:33891835chr5:34035863ENST00000504830-1241535_1575421595.0DomainPLAC
HgeneADAMTS12chr5:33891835chr5:34035863ENST00000504830-124246_456421595.0DomainPeptidase M12B
HgeneADAMTS12chr5:33891835chr5:34035863ENST00000504830-124465_544421595.0DomainNote=Disintegrin
HgeneADAMTS12chr5:33891835chr5:34035863ENST00000504830-124542_597421595.0DomainTSP type-1 1
HgeneADAMTS12chr5:33891835chr5:34035863ENST00000504830-124823_883421595.0DomainTSP type-1 2
HgeneADAMTS12chr5:33891835chr5:34035863ENST00000504830-124887_943421595.0DomainTSP type-1 3
HgeneADAMTS12chr5:33891835chr5:34035863ENST00000504830-124944_997421595.0DomainTSP type-1 4
HgeneADAMTS12chr5:33891835chr5:34035863ENST00000352040-122208_213421510.0MotifCysteine switch
HgeneADAMTS12chr5:33891835chr5:34035863ENST00000504830-124208_213421595.0MotifCysteine switch
HgeneADAMTS12chr5:33891835chr5:34035863ENST00000352040-122701_827421510.0RegionNote=Spacer 1
HgeneADAMTS12chr5:33891835chr5:34035863ENST00000352040-122997_1316421510.0RegionNote=Spacer 2
HgeneADAMTS12chr5:33891835chr5:34035863ENST00000504830-124701_827421595.0RegionNote=Spacer 1
HgeneADAMTS12chr5:33891835chr5:34035863ENST00000504830-124997_1316421595.0RegionNote=Spacer 2
TgeneC1QTNF3chr5:33891835chr5:34035863ENST000003820650651_113101320.0DomainNote=Collagen-like


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Fusion Gene Sequence for ADAMTS12-C1QTNF3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>2041_2041_1_ADAMTS12-C1QTNF3_ADAMTS12_chr5_33891835_ENST00000352040_C1QTNF3_chr5_34035863_ENST00000231338_length(transcript)=1999nt_BP=212nt
TCCTGCTGGGCCACAGGCGAGCGCTTTATTTCTGGAGCTGAGGGCTAAAACTTTTTTGACTTTTCTTCTCCTCAACATCTGAATCATGCC
ATGTGCCCAGAGGAGCTGGCTTGCAAACCTTTCCGTGGTGGCTCAGCTCCTTAACTTTGGGGCGCTTTGCTATGGGAGACAGCCTCAGCC
AGGCCCGGTTCGCTTCCCGGACAGGAGGCAAGTCTCCACAAACCGGAGGACTACCCCCAGACTGCAGTAAGTGTTGTCATGGAGACTACA
GCTTTCGAGGCTACCAAGGCCCCCCTGGGCCACCGGGCCCTCCTGGCATTCCAGGAAACCATGGAAACAATGGCAACAATGGAGCCACTG
GTCATGAAGGAGCCAAAGGTGAGAAGGGCGACAAAGGTGACCTGGGGCCTCGAGGGGAGCGGGGGCAGCATGGCCCCAAAGGAGAGAAGG
GCTACCCGGGGATTCCACCAGAACTTCAGATTGCATTCATGGCTTCTCTGGCAACCCACTTCAGCAATCAGAACAGTGGGATTATCTTCA
GCAGTGTTGAGACCAACATTGGAAACTTCTTTGATGTCATGACTGGTAGATTTGGGGCCCCAGTATCAGGTGTGTATTTCTTCACCTTCA
GCATGATGAAGCATGAGGATGTTGAGGAAGTGTATGTGTACCTTATGCACAATGGCAACACAGTCTTCAGCATGTACAGCTATGAAATGA
AGGGCAAATCAGATACATCCAGCAATCATGCTGTGCTGAAGCTAGCCAAAGGGGATGAGGTTTGGCTGCGAATGGGCAATGGCGCTCTCC
ATGGGGACCACCAACGCTTCTCCACCTTTGCAGGATTCCTGCTCTTTGAAACTAAGTAAATATATGACTAGAATAGCTCCACTTTGGGGA
AGACTTGTAGCTGAGCTGATTTGTTACGATCTGAGGAACATTAAAGTTGAGGGTTTTACATTGCTGTATTCAAAAAATTATTGGTTGCAA
TGTTGTTCACGCTACAGGTACACCAATAATGTTGGACAATTCAGGGGCTCAGAAGAATCAACCACAAAATAGTCTTCTCAGATGACCTTG
ACTAATATACTCAGCATCTTTATCACTCTTTCCTTGGCACCTAAAAGATAATTCTCCTCTGACGCAGGTTGGAAATATTTTTTTCTATCA
CAGAAGTCATTTGCAAAGAATTTTGACTACTCTGCTTTTAATTTAATACCAGTTTTCAGGAACCCCTGAAGTTTTAAGTTCATTATTCTT
TATAACATTTGAGAGAATCGGATGTAGTGATATGACAGGGCTGGGGCAAGAACAGGGGCACTAGCTGCCTTATTAGCTAATTTAGTGCCC
TCCGTGTTCAGCTTAGCCTTTGACCCTTTCCTTTTGATCCACAAAATACATTAAAACTCTGAATTCACATACAATGCTATTTTAAAGTCA
ATAGATTTTAGCTATAAAGTGCTTGACCAGTAATGTGGTTGTAATTTTGTGTATGTTCCCCCACATCGCCCCCAACTTCGGATGTGGGGT
CAGGAGGTTGAGGTTCACTATTAACAAATGTCATAAATATCTCATAGAGGTACAGTGCCAATAGATATTCAAATGTTGCATGTTGACCAG
AGGGATTTTATATCTGAAGAACATACACTATTAATAAATACCTTAGAGAAAGATTTTGACCTGGCTTTAGATAAAACTGTGGCAAGAAAA
ATGTAATGAGCAATATATGGAAATAAACACACCTTTGTTAAAGATACTTTCTAAACTTGTGTTTAATAAACTTTAATAGTCATAGAATTG
TAAATCACTATGGTTAACAGAAAGTGAAAATATTTTCATGCAGATGATGTGAACAGCCATGTGAATAGGTGACTTGGGCACACAGCAGGG
TCATATGACTTCAGAAAACTTCGCTTTTCAGTTATTCCATTGTTATAATGTCAACCCTTTAAGACATTGATGTTTAGAGGGCTCACAAAT

>2041_2041_1_ADAMTS12-C1QTNF3_ADAMTS12_chr5_33891835_ENST00000352040_C1QTNF3_chr5_34035863_ENST00000231338_length(amino acids)=252AA_BP=34
MQTFPWWLSSLTLGRFAMGDSLSQARFASRTGGKSPQTGGLPPDCSKCCHGDYSFRGYQGPPGPPGPPGIPGNHGNNGNNGATGHEGAKG
EKGDKGDLGPRGERGQHGPKGEKGYPGIPPELQIAFMASLATHFSNQNSGIIFSSVETNIGNFFDVMTGRFGAPVSGVYFFTFSMMKHED

--------------------------------------------------------------
>2041_2041_2_ADAMTS12-C1QTNF3_ADAMTS12_chr5_33891835_ENST00000352040_C1QTNF3_chr5_34035863_ENST00000382065_length(transcript)=2004nt_BP=212nt
TCCTGCTGGGCCACAGGCGAGCGCTTTATTTCTGGAGCTGAGGGCTAAAACTTTTTTGACTTTTCTTCTCCTCAACATCTGAATCATGCC
ATGTGCCCAGAGGAGCTGGCTTGCAAACCTTTCCGTGGTGGCTCAGCTCCTTAACTTTGGGGCGCTTTGCTATGGGAGACAGCCTCAGCC
AGGCCCGGTTCGCTTCCCGGACAGGAGGCAAGTCTCCACAAACCGGAGGACTACCCCCAGACTGCAGTAAGTGTTGTCATGGAGACTACA
GCTTTCGAGGCTACCAAGGCCCCCCTGGGCCACCGGGCCCTCCTGGCATTCCAGGAAACCATGGAAACAATGGCAACAATGGAGCCACTG
GTCATGAAGGAGCCAAAGGTGAGAAGGGCGACAAAGGTGACCTGGGGCCTCGAGGGGAGCGGGGGCAGCATGGCCCCAAAGGAGAGAAGG
GCTACCCGGGGATTCCACCAGAACTTCAGATTGCATTCATGGCTTCTCTGGCAACCCACTTCAGCAATCAGAACAGTGGGATTATCTTCA
GCAGTGTTGAGACCAACATTGGAAACTTCTTTGATGTCATGACTGGTAGATTTGGGGCCCCAGTATCAGGTGTGTATTTCTTCACCTTCA
GCATGATGAAGCATGAGGATGTTGAGGAAGTGTATGTGTACCTTATGCACAATGGCAACACAGTCTTCAGCATGTACAGCTATGAAATGA
AGGGCAAATCAGATACATCCAGCAATCATGCTGTGCTGAAGCTAGCCAAAGGGGATGAGGTTTGGCTGCGAATGGGCAATGGCGCTCTCC
ATGGGGACCACCAACGCTTCTCCACCTTTGCAGGATTCCTGCTCTTTGAAACTAAGTAAATATATGACTAGAATAGCTCCACTTTGGGGA
AGACTTGTAGCTGAGCTGATTTGTTACGATCTGAGGAACATTAAAGTTGAGGGTTTTACATTGCTGTATTCAAAAAATTATTGGTTGCAA
TGTTGTTCACGCTACAGGTACACCAATAATGTTGGACAATTCAGGGGCTCAGAAGAATCAACCACAAAATAGTCTTCTCAGATGACCTTG
ACTAATATACTCAGCATCTTTATCACTCTTTCCTTGGCACCTAAAAGATAATTCTCCTCTGACGCAGGTTGGAAATATTTTTTTCTATCA
CAGAAGTCATTTGCAAAGAATTTTGACTACTCTGCTTTTAATTTAATACCAGTTTTCAGGAACCCCTGAAGTTTTAAGTTCATTATTCTT
TATAACATTTGAGAGAATCGGATGTAGTGATATGACAGGGCTGGGGCAAGAACAGGGGCACTAGCTGCCTTATTAGCTAATTTAGTGCCC
TCCGTGTTCAGCTTAGCCTTTGACCCTTTCCTTTTGATCCACAAAATACATTAAAACTCTGAATTCACATACAATGCTATTTTAAAGTCA
ATAGATTTTAGCTATAAAGTGCTTGACCAGTAATGTGGTTGTAATTTTGTGTATGTTCCCCCACATCGCCCCCAACTTCGGATGTGGGGT
CAGGAGGTTGAGGTTCACTATTAACAAATGTCATAAATATCTCATAGAGGTACAGTGCCAATAGATATTCAAATGTTGCATGTTGACCAG
AGGGATTTTATATCTGAAGAACATACACTATTAATAAATACCTTAGAGAAAGATTTTGACCTGGCTTTAGATAAAACTGTGGCAAGAAAA
ATGTAATGAGCAATATATGGAAATAAACACACCTTTGTTAAAGATACTTTCTAAACTTGTGTTTAATAAACTTTAATAGTCATAGAATTG
TAAATCACTATGGTTAACAGAAAGTGAAAATATTTTCATGCAGATGATGTGAACAGCCATGTGAATAGGTGACTTGGGCACACAGCAGGG
TCATATGACTTCAGAAAACTTCGCTTTTCAGTTATTCCATTGTTATAATGTCAACCCTTTAAGACATTGATGTTTAGAGGGCTCACAAAT

>2041_2041_2_ADAMTS12-C1QTNF3_ADAMTS12_chr5_33891835_ENST00000352040_C1QTNF3_chr5_34035863_ENST00000382065_length(amino acids)=252AA_BP=34
MQTFPWWLSSLTLGRFAMGDSLSQARFASRTGGKSPQTGGLPPDCSKCCHGDYSFRGYQGPPGPPGPPGIPGNHGNNGNNGATGHEGAKG
EKGDKGDLGPRGERGQHGPKGEKGYPGIPPELQIAFMASLATHFSNQNSGIIFSSVETNIGNFFDVMTGRFGAPVSGVYFFTFSMMKHED

--------------------------------------------------------------
>2041_2041_3_ADAMTS12-C1QTNF3_ADAMTS12_chr5_33891835_ENST00000504830_C1QTNF3_chr5_34035863_ENST00000231338_length(transcript)=2250nt_BP=463nt
GAGCGGGCGGGCTGCGAGGCCGCGGGGCATGCGGGAGGCGGAGGGGTGGGGACCGGGGTGGGCTGCGCCCTCCCGCTCTGGCCCATTCCA
CACCCCGCCGAAAGCGGACACTGTCAGCTGAATCACTCCCCTTTTAGGAGGAGGGAGGGGAAAAAGGTGTCTAGCTCCTTTCTGCTTAAA
AAAGCACAGGGAGATCGCGGGCAGCTTTGCAGTCGCTGCCTTCTCGCGCCTGACCATGCACCCCTGCATCTTCCTGCTGGGCCACAGGCG
AGCGCTTTATTTCTGGAGCTGAGGGCTAAAACTTTTTTGACTTTTCTTCTCCTCAACATCTGAATCATGCCATGTGCCCAGAGGAGCTGG
CTTGCAAACCTTTCCGTGGTGGCTCAGCTCCTTAACTTTGGGGCGCTTTGCTATGGGAGACAGCCTCAGCCAGGCCCGGTTCGCTTCCCG
GACAGGAGGCAAGTCTCCACAAACCGGAGGACTACCCCCAGACTGCAGTAAGTGTTGTCATGGAGACTACAGCTTTCGAGGCTACCAAGG
CCCCCCTGGGCCACCGGGCCCTCCTGGCATTCCAGGAAACCATGGAAACAATGGCAACAATGGAGCCACTGGTCATGAAGGAGCCAAAGG
TGAGAAGGGCGACAAAGGTGACCTGGGGCCTCGAGGGGAGCGGGGGCAGCATGGCCCCAAAGGAGAGAAGGGCTACCCGGGGATTCCACC
AGAACTTCAGATTGCATTCATGGCTTCTCTGGCAACCCACTTCAGCAATCAGAACAGTGGGATTATCTTCAGCAGTGTTGAGACCAACAT
TGGAAACTTCTTTGATGTCATGACTGGTAGATTTGGGGCCCCAGTATCAGGTGTGTATTTCTTCACCTTCAGCATGATGAAGCATGAGGA
TGTTGAGGAAGTGTATGTGTACCTTATGCACAATGGCAACACAGTCTTCAGCATGTACAGCTATGAAATGAAGGGCAAATCAGATACATC
CAGCAATCATGCTGTGCTGAAGCTAGCCAAAGGGGATGAGGTTTGGCTGCGAATGGGCAATGGCGCTCTCCATGGGGACCACCAACGCTT
CTCCACCTTTGCAGGATTCCTGCTCTTTGAAACTAAGTAAATATATGACTAGAATAGCTCCACTTTGGGGAAGACTTGTAGCTGAGCTGA
TTTGTTACGATCTGAGGAACATTAAAGTTGAGGGTTTTACATTGCTGTATTCAAAAAATTATTGGTTGCAATGTTGTTCACGCTACAGGT
ACACCAATAATGTTGGACAATTCAGGGGCTCAGAAGAATCAACCACAAAATAGTCTTCTCAGATGACCTTGACTAATATACTCAGCATCT
TTATCACTCTTTCCTTGGCACCTAAAAGATAATTCTCCTCTGACGCAGGTTGGAAATATTTTTTTCTATCACAGAAGTCATTTGCAAAGA
ATTTTGACTACTCTGCTTTTAATTTAATACCAGTTTTCAGGAACCCCTGAAGTTTTAAGTTCATTATTCTTTATAACATTTGAGAGAATC
GGATGTAGTGATATGACAGGGCTGGGGCAAGAACAGGGGCACTAGCTGCCTTATTAGCTAATTTAGTGCCCTCCGTGTTCAGCTTAGCCT
TTGACCCTTTCCTTTTGATCCACAAAATACATTAAAACTCTGAATTCACATACAATGCTATTTTAAAGTCAATAGATTTTAGCTATAAAG
TGCTTGACCAGTAATGTGGTTGTAATTTTGTGTATGTTCCCCCACATCGCCCCCAACTTCGGATGTGGGGTCAGGAGGTTGAGGTTCACT
ATTAACAAATGTCATAAATATCTCATAGAGGTACAGTGCCAATAGATATTCAAATGTTGCATGTTGACCAGAGGGATTTTATATCTGAAG
AACATACACTATTAATAAATACCTTAGAGAAAGATTTTGACCTGGCTTTAGATAAAACTGTGGCAAGAAAAATGTAATGAGCAATATATG
GAAATAAACACACCTTTGTTAAAGATACTTTCTAAACTTGTGTTTAATAAACTTTAATAGTCATAGAATTGTAAATCACTATGGTTAACA
GAAAGTGAAAATATTTTCATGCAGATGATGTGAACAGCCATGTGAATAGGTGACTTGGGCACACAGCAGGGTCATATGACTTCAGAAAAC
TTCGCTTTTCAGTTATTCCATTGTTATAATGTCAACCCTTTAAGACATTGATGTTTAGAGGGCTCACAAATAAAATCTGAATACCTGTAA

>2041_2041_3_ADAMTS12-C1QTNF3_ADAMTS12_chr5_33891835_ENST00000504830_C1QTNF3_chr5_34035863_ENST00000231338_length(amino acids)=252AA_BP=34
MQTFPWWLSSLTLGRFAMGDSLSQARFASRTGGKSPQTGGLPPDCSKCCHGDYSFRGYQGPPGPPGPPGIPGNHGNNGNNGATGHEGAKG
EKGDKGDLGPRGERGQHGPKGEKGYPGIPPELQIAFMASLATHFSNQNSGIIFSSVETNIGNFFDVMTGRFGAPVSGVYFFTFSMMKHED

--------------------------------------------------------------
>2041_2041_4_ADAMTS12-C1QTNF3_ADAMTS12_chr5_33891835_ENST00000504830_C1QTNF3_chr5_34035863_ENST00000382065_length(transcript)=2255nt_BP=463nt
GAGCGGGCGGGCTGCGAGGCCGCGGGGCATGCGGGAGGCGGAGGGGTGGGGACCGGGGTGGGCTGCGCCCTCCCGCTCTGGCCCATTCCA
CACCCCGCCGAAAGCGGACACTGTCAGCTGAATCACTCCCCTTTTAGGAGGAGGGAGGGGAAAAAGGTGTCTAGCTCCTTTCTGCTTAAA
AAAGCACAGGGAGATCGCGGGCAGCTTTGCAGTCGCTGCCTTCTCGCGCCTGACCATGCACCCCTGCATCTTCCTGCTGGGCCACAGGCG
AGCGCTTTATTTCTGGAGCTGAGGGCTAAAACTTTTTTGACTTTTCTTCTCCTCAACATCTGAATCATGCCATGTGCCCAGAGGAGCTGG
CTTGCAAACCTTTCCGTGGTGGCTCAGCTCCTTAACTTTGGGGCGCTTTGCTATGGGAGACAGCCTCAGCCAGGCCCGGTTCGCTTCCCG
GACAGGAGGCAAGTCTCCACAAACCGGAGGACTACCCCCAGACTGCAGTAAGTGTTGTCATGGAGACTACAGCTTTCGAGGCTACCAAGG
CCCCCCTGGGCCACCGGGCCCTCCTGGCATTCCAGGAAACCATGGAAACAATGGCAACAATGGAGCCACTGGTCATGAAGGAGCCAAAGG
TGAGAAGGGCGACAAAGGTGACCTGGGGCCTCGAGGGGAGCGGGGGCAGCATGGCCCCAAAGGAGAGAAGGGCTACCCGGGGATTCCACC
AGAACTTCAGATTGCATTCATGGCTTCTCTGGCAACCCACTTCAGCAATCAGAACAGTGGGATTATCTTCAGCAGTGTTGAGACCAACAT
TGGAAACTTCTTTGATGTCATGACTGGTAGATTTGGGGCCCCAGTATCAGGTGTGTATTTCTTCACCTTCAGCATGATGAAGCATGAGGA
TGTTGAGGAAGTGTATGTGTACCTTATGCACAATGGCAACACAGTCTTCAGCATGTACAGCTATGAAATGAAGGGCAAATCAGATACATC
CAGCAATCATGCTGTGCTGAAGCTAGCCAAAGGGGATGAGGTTTGGCTGCGAATGGGCAATGGCGCTCTCCATGGGGACCACCAACGCTT
CTCCACCTTTGCAGGATTCCTGCTCTTTGAAACTAAGTAAATATATGACTAGAATAGCTCCACTTTGGGGAAGACTTGTAGCTGAGCTGA
TTTGTTACGATCTGAGGAACATTAAAGTTGAGGGTTTTACATTGCTGTATTCAAAAAATTATTGGTTGCAATGTTGTTCACGCTACAGGT
ACACCAATAATGTTGGACAATTCAGGGGCTCAGAAGAATCAACCACAAAATAGTCTTCTCAGATGACCTTGACTAATATACTCAGCATCT
TTATCACTCTTTCCTTGGCACCTAAAAGATAATTCTCCTCTGACGCAGGTTGGAAATATTTTTTTCTATCACAGAAGTCATTTGCAAAGA
ATTTTGACTACTCTGCTTTTAATTTAATACCAGTTTTCAGGAACCCCTGAAGTTTTAAGTTCATTATTCTTTATAACATTTGAGAGAATC
GGATGTAGTGATATGACAGGGCTGGGGCAAGAACAGGGGCACTAGCTGCCTTATTAGCTAATTTAGTGCCCTCCGTGTTCAGCTTAGCCT
TTGACCCTTTCCTTTTGATCCACAAAATACATTAAAACTCTGAATTCACATACAATGCTATTTTAAAGTCAATAGATTTTAGCTATAAAG
TGCTTGACCAGTAATGTGGTTGTAATTTTGTGTATGTTCCCCCACATCGCCCCCAACTTCGGATGTGGGGTCAGGAGGTTGAGGTTCACT
ATTAACAAATGTCATAAATATCTCATAGAGGTACAGTGCCAATAGATATTCAAATGTTGCATGTTGACCAGAGGGATTTTATATCTGAAG
AACATACACTATTAATAAATACCTTAGAGAAAGATTTTGACCTGGCTTTAGATAAAACTGTGGCAAGAAAAATGTAATGAGCAATATATG
GAAATAAACACACCTTTGTTAAAGATACTTTCTAAACTTGTGTTTAATAAACTTTAATAGTCATAGAATTGTAAATCACTATGGTTAACA
GAAAGTGAAAATATTTTCATGCAGATGATGTGAACAGCCATGTGAATAGGTGACTTGGGCACACAGCAGGGTCATATGACTTCAGAAAAC
TTCGCTTTTCAGTTATTCCATTGTTATAATGTCAACCCTTTAAGACATTGATGTTTAGAGGGCTCACAAATAAAATCTGAATACCTGTAA

>2041_2041_4_ADAMTS12-C1QTNF3_ADAMTS12_chr5_33891835_ENST00000504830_C1QTNF3_chr5_34035863_ENST00000382065_length(amino acids)=252AA_BP=34
MQTFPWWLSSLTLGRFAMGDSLSQARFASRTGGKSPQTGGLPPDCSKCCHGDYSFRGYQGPPGPPGPPGIPGNHGNNGNNGATGHEGAKG
EKGDKGDLGPRGERGQHGPKGEKGYPGIPPELQIAFMASLATHFSNQNSGIIFSSVETNIGNFFDVMTGRFGAPVSGVYFFTFSMMKHED

--------------------------------------------------------------
>2041_2041_5_ADAMTS12-C1QTNF3_ADAMTS12_chr5_33891835_ENST00000515401_C1QTNF3_chr5_34035863_ENST00000231338_length(transcript)=2077nt_BP=290nt
GCTTAAAAAAGCACAGGGAGATCGCGGGCAGCTTTGCAGTCGCTGCCTTCTCGCGCCTGACCATGCACCCCTGCATCTTCCTGCTGGGCC
ACAGGCGAGCGCTTTATTTCTGGAGCTGAGGGCTAAAACTTTTTTGACTTTTCTTCTCCTCAACATCTGAATCATGCCATGTGCCCAGAG
GAGCTGGCTTGCAAACCTTTCCGTGGTGGCTCAGCTCCTTAACTTTGGGGCGCTTTGCTATGGGAGACAGCCTCAGCCAGGCCCGGTTCG
CTTCCCGGACAGGAGGCAAGTCTCCACAAACCGGAGGACTACCCCCAGACTGCAGTAAGTGTTGTCATGGAGACTACAGCTTTCGAGGCT
ACCAAGGCCCCCCTGGGCCACCGGGCCCTCCTGGCATTCCAGGAAACCATGGAAACAATGGCAACAATGGAGCCACTGGTCATGAAGGAG
CCAAAGGTGAGAAGGGCGACAAAGGTGACCTGGGGCCTCGAGGGGAGCGGGGGCAGCATGGCCCCAAAGGAGAGAAGGGCTACCCGGGGA
TTCCACCAGAACTTCAGATTGCATTCATGGCTTCTCTGGCAACCCACTTCAGCAATCAGAACAGTGGGATTATCTTCAGCAGTGTTGAGA
CCAACATTGGAAACTTCTTTGATGTCATGACTGGTAGATTTGGGGCCCCAGTATCAGGTGTGTATTTCTTCACCTTCAGCATGATGAAGC
ATGAGGATGTTGAGGAAGTGTATGTGTACCTTATGCACAATGGCAACACAGTCTTCAGCATGTACAGCTATGAAATGAAGGGCAAATCAG
ATACATCCAGCAATCATGCTGTGCTGAAGCTAGCCAAAGGGGATGAGGTTTGGCTGCGAATGGGCAATGGCGCTCTCCATGGGGACCACC
AACGCTTCTCCACCTTTGCAGGATTCCTGCTCTTTGAAACTAAGTAAATATATGACTAGAATAGCTCCACTTTGGGGAAGACTTGTAGCT
GAGCTGATTTGTTACGATCTGAGGAACATTAAAGTTGAGGGTTTTACATTGCTGTATTCAAAAAATTATTGGTTGCAATGTTGTTCACGC
TACAGGTACACCAATAATGTTGGACAATTCAGGGGCTCAGAAGAATCAACCACAAAATAGTCTTCTCAGATGACCTTGACTAATATACTC
AGCATCTTTATCACTCTTTCCTTGGCACCTAAAAGATAATTCTCCTCTGACGCAGGTTGGAAATATTTTTTTCTATCACAGAAGTCATTT
GCAAAGAATTTTGACTACTCTGCTTTTAATTTAATACCAGTTTTCAGGAACCCCTGAAGTTTTAAGTTCATTATTCTTTATAACATTTGA
GAGAATCGGATGTAGTGATATGACAGGGCTGGGGCAAGAACAGGGGCACTAGCTGCCTTATTAGCTAATTTAGTGCCCTCCGTGTTCAGC
TTAGCCTTTGACCCTTTCCTTTTGATCCACAAAATACATTAAAACTCTGAATTCACATACAATGCTATTTTAAAGTCAATAGATTTTAGC
TATAAAGTGCTTGACCAGTAATGTGGTTGTAATTTTGTGTATGTTCCCCCACATCGCCCCCAACTTCGGATGTGGGGTCAGGAGGTTGAG
GTTCACTATTAACAAATGTCATAAATATCTCATAGAGGTACAGTGCCAATAGATATTCAAATGTTGCATGTTGACCAGAGGGATTTTATA
TCTGAAGAACATACACTATTAATAAATACCTTAGAGAAAGATTTTGACCTGGCTTTAGATAAAACTGTGGCAAGAAAAATGTAATGAGCA
ATATATGGAAATAAACACACCTTTGTTAAAGATACTTTCTAAACTTGTGTTTAATAAACTTTAATAGTCATAGAATTGTAAATCACTATG
GTTAACAGAAAGTGAAAATATTTTCATGCAGATGATGTGAACAGCCATGTGAATAGGTGACTTGGGCACACAGCAGGGTCATATGACTTC
AGAAAACTTCGCTTTTCAGTTATTCCATTGTTATAATGTCAACCCTTTAAGACATTGATGTTTAGAGGGCTCACAAATAAAATCTGAATA

>2041_2041_5_ADAMTS12-C1QTNF3_ADAMTS12_chr5_33891835_ENST00000515401_C1QTNF3_chr5_34035863_ENST00000231338_length(amino acids)=252AA_BP=34
MQTFPWWLSSLTLGRFAMGDSLSQARFASRTGGKSPQTGGLPPDCSKCCHGDYSFRGYQGPPGPPGPPGIPGNHGNNGNNGATGHEGAKG
EKGDKGDLGPRGERGQHGPKGEKGYPGIPPELQIAFMASLATHFSNQNSGIIFSSVETNIGNFFDVMTGRFGAPVSGVYFFTFSMMKHED

--------------------------------------------------------------
>2041_2041_6_ADAMTS12-C1QTNF3_ADAMTS12_chr5_33891835_ENST00000515401_C1QTNF3_chr5_34035863_ENST00000382065_length(transcript)=2082nt_BP=290nt
GCTTAAAAAAGCACAGGGAGATCGCGGGCAGCTTTGCAGTCGCTGCCTTCTCGCGCCTGACCATGCACCCCTGCATCTTCCTGCTGGGCC
ACAGGCGAGCGCTTTATTTCTGGAGCTGAGGGCTAAAACTTTTTTGACTTTTCTTCTCCTCAACATCTGAATCATGCCATGTGCCCAGAG
GAGCTGGCTTGCAAACCTTTCCGTGGTGGCTCAGCTCCTTAACTTTGGGGCGCTTTGCTATGGGAGACAGCCTCAGCCAGGCCCGGTTCG
CTTCCCGGACAGGAGGCAAGTCTCCACAAACCGGAGGACTACCCCCAGACTGCAGTAAGTGTTGTCATGGAGACTACAGCTTTCGAGGCT
ACCAAGGCCCCCCTGGGCCACCGGGCCCTCCTGGCATTCCAGGAAACCATGGAAACAATGGCAACAATGGAGCCACTGGTCATGAAGGAG
CCAAAGGTGAGAAGGGCGACAAAGGTGACCTGGGGCCTCGAGGGGAGCGGGGGCAGCATGGCCCCAAAGGAGAGAAGGGCTACCCGGGGA
TTCCACCAGAACTTCAGATTGCATTCATGGCTTCTCTGGCAACCCACTTCAGCAATCAGAACAGTGGGATTATCTTCAGCAGTGTTGAGA
CCAACATTGGAAACTTCTTTGATGTCATGACTGGTAGATTTGGGGCCCCAGTATCAGGTGTGTATTTCTTCACCTTCAGCATGATGAAGC
ATGAGGATGTTGAGGAAGTGTATGTGTACCTTATGCACAATGGCAACACAGTCTTCAGCATGTACAGCTATGAAATGAAGGGCAAATCAG
ATACATCCAGCAATCATGCTGTGCTGAAGCTAGCCAAAGGGGATGAGGTTTGGCTGCGAATGGGCAATGGCGCTCTCCATGGGGACCACC
AACGCTTCTCCACCTTTGCAGGATTCCTGCTCTTTGAAACTAAGTAAATATATGACTAGAATAGCTCCACTTTGGGGAAGACTTGTAGCT
GAGCTGATTTGTTACGATCTGAGGAACATTAAAGTTGAGGGTTTTACATTGCTGTATTCAAAAAATTATTGGTTGCAATGTTGTTCACGC
TACAGGTACACCAATAATGTTGGACAATTCAGGGGCTCAGAAGAATCAACCACAAAATAGTCTTCTCAGATGACCTTGACTAATATACTC
AGCATCTTTATCACTCTTTCCTTGGCACCTAAAAGATAATTCTCCTCTGACGCAGGTTGGAAATATTTTTTTCTATCACAGAAGTCATTT
GCAAAGAATTTTGACTACTCTGCTTTTAATTTAATACCAGTTTTCAGGAACCCCTGAAGTTTTAAGTTCATTATTCTTTATAACATTTGA
GAGAATCGGATGTAGTGATATGACAGGGCTGGGGCAAGAACAGGGGCACTAGCTGCCTTATTAGCTAATTTAGTGCCCTCCGTGTTCAGC
TTAGCCTTTGACCCTTTCCTTTTGATCCACAAAATACATTAAAACTCTGAATTCACATACAATGCTATTTTAAAGTCAATAGATTTTAGC
TATAAAGTGCTTGACCAGTAATGTGGTTGTAATTTTGTGTATGTTCCCCCACATCGCCCCCAACTTCGGATGTGGGGTCAGGAGGTTGAG
GTTCACTATTAACAAATGTCATAAATATCTCATAGAGGTACAGTGCCAATAGATATTCAAATGTTGCATGTTGACCAGAGGGATTTTATA
TCTGAAGAACATACACTATTAATAAATACCTTAGAGAAAGATTTTGACCTGGCTTTAGATAAAACTGTGGCAAGAAAAATGTAATGAGCA
ATATATGGAAATAAACACACCTTTGTTAAAGATACTTTCTAAACTTGTGTTTAATAAACTTTAATAGTCATAGAATTGTAAATCACTATG
GTTAACAGAAAGTGAAAATATTTTCATGCAGATGATGTGAACAGCCATGTGAATAGGTGACTTGGGCACACAGCAGGGTCATATGACTTC
AGAAAACTTCGCTTTTCAGTTATTCCATTGTTATAATGTCAACCCTTTAAGACATTGATGTTTAGAGGGCTCACAAATAAAATCTGAATA

>2041_2041_6_ADAMTS12-C1QTNF3_ADAMTS12_chr5_33891835_ENST00000515401_C1QTNF3_chr5_34035863_ENST00000382065_length(amino acids)=252AA_BP=34
MQTFPWWLSSLTLGRFAMGDSLSQARFASRTGGKSPQTGGLPPDCSKCCHGDYSFRGYQGPPGPPGPPGIPGNHGNNGNNGATGHEGAKG
EKGDKGDLGPRGERGQHGPKGEKGYPGIPPELQIAFMASLATHFSNQNSGIIFSSVETNIGNFFDVMTGRFGAPVSGVYFFTFSMMKHED

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ADAMTS12-C1QTNF3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ADAMTS12-C1QTNF3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ADAMTS12-C1QTNF3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneADAMTS12C0036341Schizophrenia1PSYGENET