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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
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Fusion gene:ADAMTS12-C1QTNF3 (FusionGDB2 ID:HG81792TG114899)

Fusion Gene Summary for ADAMTS12-C1QTNF3

Fusion gene summary

Fusion gene information	Fusion gene name: ADAMTS12-C1QTNF3
	Fusion gene ID: hg81792tg114899
		Hgene	Tgene
	Gene symbol	ADAMTS12	C1QTNF3
	Gene ID	81792	114899
	Gene name	ADAM metallopeptidase with thrombospondin type 1 motif 12	C1q and TNF related 3
	Synonyms	PRO4389	C1ATNF3\|CORCS\|CORS\|CORS-26\|CORS26\|CTRP3
	Cytomap	('ADAMTS12')('C1QTNF3') 5p13.3-p13.2	5p13.2
	Type of gene	protein-coding	protein-coding
	Description	A disintegrin and metalloproteinase with thrombospondin motifs 12ADAM-TS 12ADAM-TS12ADAMTS-12a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12	complement C1q tumor necrosis factor-related protein 3C1q and tumor necrosis factor related protein 3cartonectincollagenous repeat-containing sequence 26 kDa proteincollagenous repeat-containing sequence of 26-kDasecretory protein CORS26
	Modification date	20200313	20200322
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000352040, ENST00000504830, ENST00000515401, ENST00000504582,
Fusion gene scores	* DoF score	6 X 6 X 4=144	7 X 3 X 6=126
	# samples	6	8
	** MAII score	log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/126*10)=-0.655351828612554 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ADAMTS12 [Title/Abstract] AND C1QTNF3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ADAMTS12(33891835)-C1QTNF3(34035863), # samples:1
Anticipated loss of major functional domain due to fusion event.	ADAMTS12-C1QTNF3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ADAMTS12-C1QTNF3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ADAMTS12-C1QTNF3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ADAMTS12-C1QTNF3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ADAMTS12	GO:0030167	proteoglycan catabolic process	17895370
Hgene	ADAMTS12	GO:0032331	negative regulation of chondrocyte differentiation	22247065
Hgene	ADAMTS12	GO:0050727	regulation of inflammatory response	23019333
Hgene	ADAMTS12	GO:0051603	proteolysis involved in cellular protein catabolic process	16611630
Hgene	ADAMTS12	GO:0071773	cellular response to BMP stimulus	22247065
Hgene	ADAMTS12	GO:1901509	regulation of endothelial tube morphogenesis	17895370
Hgene	ADAMTS12	GO:1902203	negative regulation of hepatocyte growth factor receptor signaling pathway	17895370
Hgene	ADAMTS12	GO:1902548	negative regulation of cellular response to vascular endothelial growth factor stimulus	17895370
Hgene	ADAMTS12	GO:2001113	negative regulation of cellular response to hepatocyte growth factor stimulus	17895370
Tgene	C1QTNF3	GO:0035356	cellular triglyceride homeostasis	20739398
Tgene	C1QTNF3	GO:0045721	negative regulation of gluconeogenesis	20952387
Tgene	C1QTNF3	GO:0050715	positive regulation of cytokine secretion	18421280
Tgene	C1QTNF3	GO:0050728	negative regulation of inflammatory response	16213490
Tgene	C1QTNF3	GO:0070165	positive regulation of adiponectin secretion	18421280
Tgene	C1QTNF3	GO:0071638	negative regulation of monocyte chemotactic protein-1 production	20739398
Tgene	C1QTNF3	GO:1900165	negative regulation of interleukin-6 secretion	16213490
Tgene	C1QTNF3	GO:1901223	negative regulation of NIK/NF-kappaB signaling	16213490

Fusion gene breakpoints across ADAMTS12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across C1QTNF3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AN-A0AR-01A	ADAMTS12	chr5	33891835	-	C1QTNF3	chr5	34035863	-

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Fusion Gene ORF analysis for ADAMTS12-C1QTNF3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000352040	ENST00000513065	ADAMTS12	chr5	33891835	-	C1QTNF3	chr5	34035863	-
5CDS-intron	ENST00000504830	ENST00000513065	ADAMTS12	chr5	33891835	-	C1QTNF3	chr5	34035863	-
5CDS-intron	ENST00000515401	ENST00000513065	ADAMTS12	chr5	33891835	-	C1QTNF3	chr5	34035863	-
In-frame	ENST00000352040	ENST00000231338	ADAMTS12	chr5	33891835	-	C1QTNF3	chr5	34035863	-
In-frame	ENST00000352040	ENST00000382065	ADAMTS12	chr5	33891835	-	C1QTNF3	chr5	34035863	-
In-frame	ENST00000504830	ENST00000231338	ADAMTS12	chr5	33891835	-	C1QTNF3	chr5	34035863	-
In-frame	ENST00000504830	ENST00000382065	ADAMTS12	chr5	33891835	-	C1QTNF3	chr5	34035863	-
In-frame	ENST00000515401	ENST00000231338	ADAMTS12	chr5	33891835	-	C1QTNF3	chr5	34035863	-
In-frame	ENST00000515401	ENST00000382065	ADAMTS12	chr5	33891835	-	C1QTNF3	chr5	34035863	-
intron-3CDS	ENST00000504582	ENST00000231338	ADAMTS12	chr5	33891835	-	C1QTNF3	chr5	34035863	-
intron-3CDS	ENST00000504582	ENST00000382065	ADAMTS12	chr5	33891835	-	C1QTNF3	chr5	34035863	-
intron-intron	ENST00000504582	ENST00000513065	ADAMTS12	chr5	33891835	-	C1QTNF3	chr5	34035863	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000504830	ADAMTS12	chr5	33891835	-	ENST00000382065	C1QTNF3	chr5	34035863	-	2255	463	361	1119	252
ENST00000504830	ADAMTS12	chr5	33891835	-	ENST00000231338	C1QTNF3	chr5	34035863	-	2250	463	361	1119	252
ENST00000352040	ADAMTS12	chr5	33891835	-	ENST00000382065	C1QTNF3	chr5	34035863	-	2004	212	110	868	252
ENST00000352040	ADAMTS12	chr5	33891835	-	ENST00000231338	C1QTNF3	chr5	34035863	-	1999	212	110	868	252
ENST00000515401	ADAMTS12	chr5	33891835	-	ENST00000382065	C1QTNF3	chr5	34035863	-	2082	290	188	946	252
ENST00000515401	ADAMTS12	chr5	33891835	-	ENST00000231338	C1QTNF3	chr5	34035863	-	2077	290	188	946	252

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000504830	ENST00000382065	ADAMTS12	chr5	33891835	-	C1QTNF3	chr5	34035863	-	0.001235243	0.99876475
ENST00000504830	ENST00000231338	ADAMTS12	chr5	33891835	-	C1QTNF3	chr5	34035863	-	0.001241035	0.99875903
ENST00000352040	ENST00000382065	ADAMTS12	chr5	33891835	-	C1QTNF3	chr5	34035863	-	0.00102778	0.9989722
ENST00000352040	ENST00000231338	ADAMTS12	chr5	33891835	-	C1QTNF3	chr5	34035863	-	0.001046153	0.9989538
ENST00000515401	ENST00000382065	ADAMTS12	chr5	33891835	-	C1QTNF3	chr5	34035863	-	0.001018115	0.9989819
ENST00000515401	ENST00000231338	ADAMTS12	chr5	33891835	-	C1QTNF3	chr5	34035863	-	0.001038027	0.9989619

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Fusion Genomic Features for ADAMTS12-C1QTNF3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

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Fusion Protein Features for ADAMTS12-C1QTNF3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:33891835/chr5:34035863)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

C1QTNF3

chr5:33891835

chr5:34035863

ENST00000231338

113_246

247.0

Domain

C1q

Tgene

C1QTNF3

chr5:33891835

chr5:34035863

ENST00000231338

51_113

247.0

Domain

Note=Collagen-like

Tgene

C1QTNF3

chr5:33891835

chr5:34035863

ENST00000382065

113_246

101

320.0

Domain

C1q

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ADAMTS12

chr5:33891835

chr5:34035863

ENST00000352040

302_305

1510.0

Compositional bias

Note=Poly-Glu

Hgene

ADAMTS12

chr5:33891835

chr5:34035863

ENST00000352040

597_700

1510.0

Compositional bias

Note=Cys-rich

Hgene

ADAMTS12

chr5:33891835

chr5:34035863

ENST00000504830

302_305

1595.0

Compositional bias

Note=Poly-Glu

Hgene

ADAMTS12

chr5:33891835

chr5:34035863

ENST00000504830

597_700

1595.0

Compositional bias

Note=Cys-rich

Hgene

ADAMTS12

chr5:33891835

chr5:34035863

ENST00000352040

1313_1366

1510.0

Domain

TSP type-1 5

Hgene

ADAMTS12

chr5:33891835

chr5:34035863

ENST00000352040

1368_1422

1510.0

Domain

TSP type-1 6

Hgene

ADAMTS12

chr5:33891835

chr5:34035863

ENST00000352040

1423_1471

1510.0

Domain

TSP type-1 7

Hgene

ADAMTS12

chr5:33891835

chr5:34035863

ENST00000352040

1472_1532

1510.0

Domain

TSP type-1 8

Hgene

ADAMTS12

chr5:33891835

chr5:34035863

ENST00000352040

1535_1575

1510.0

Domain

PLAC

Hgene

ADAMTS12

chr5:33891835

chr5:34035863

ENST00000352040

246_456

1510.0

Domain

Peptidase M12B

Hgene

ADAMTS12

chr5:33891835

chr5:34035863

ENST00000352040

465_544

1510.0

Domain

Note=Disintegrin

Hgene

ADAMTS12

chr5:33891835

chr5:34035863

ENST00000352040

542_597

1510.0

Domain

TSP type-1 1

Hgene

ADAMTS12

chr5:33891835

chr5:34035863

ENST00000352040

823_883

1510.0

Domain

TSP type-1 2

Hgene

ADAMTS12

chr5:33891835

chr5:34035863

ENST00000352040

887_943

1510.0

Domain

TSP type-1 3

Hgene

ADAMTS12

chr5:33891835

chr5:34035863

ENST00000352040

944_997

1510.0

Domain

TSP type-1 4

Hgene

ADAMTS12

chr5:33891835

chr5:34035863

ENST00000504830

1313_1366

1595.0

Domain

TSP type-1 5

Hgene

ADAMTS12

chr5:33891835

chr5:34035863

ENST00000504830

1368_1422

1595.0

Domain

TSP type-1 6

Hgene

ADAMTS12

chr5:33891835

chr5:34035863

ENST00000504830

1423_1471

1595.0

Domain

TSP type-1 7

Hgene

ADAMTS12

chr5:33891835

chr5:34035863

ENST00000504830

1472_1532

1595.0

Domain

TSP type-1 8

Hgene

ADAMTS12

chr5:33891835

chr5:34035863

ENST00000504830

1535_1575

1595.0

Domain

PLAC

Hgene

ADAMTS12

chr5:33891835

chr5:34035863

ENST00000504830

246_456

1595.0

Domain

Peptidase M12B

Hgene

ADAMTS12

chr5:33891835

chr5:34035863

ENST00000504830

465_544

1595.0

Domain

Note=Disintegrin

Hgene

ADAMTS12

chr5:33891835

chr5:34035863

ENST00000504830

542_597

1595.0

Domain

TSP type-1 1

Hgene

ADAMTS12

chr5:33891835

chr5:34035863

ENST00000504830

823_883

1595.0

Domain

TSP type-1 2

Hgene

ADAMTS12

chr5:33891835

chr5:34035863

ENST00000504830

887_943

1595.0

Domain

TSP type-1 3

Hgene

ADAMTS12

chr5:33891835

chr5:34035863

ENST00000504830

944_997

1595.0

Domain

TSP type-1 4

Hgene

ADAMTS12

chr5:33891835

chr5:34035863

ENST00000352040

208_213

1510.0

Motif

Cysteine switch

Hgene

ADAMTS12

chr5:33891835

chr5:34035863

ENST00000504830

208_213

1595.0

Motif

Cysteine switch

Hgene

ADAMTS12

chr5:33891835

chr5:34035863

ENST00000352040

701_827

1510.0

Region

Note=Spacer 1

Hgene

ADAMTS12

chr5:33891835

chr5:34035863

ENST00000352040

997_1316

1510.0

Region

Note=Spacer 2

Hgene

ADAMTS12

chr5:33891835

chr5:34035863

ENST00000504830

701_827

1595.0

Region

Note=Spacer 1

Hgene

ADAMTS12

chr5:33891835

chr5:34035863

ENST00000504830

997_1316

1595.0

Region

Note=Spacer 2

Tgene

C1QTNF3

chr5:33891835

chr5:34035863

ENST00000382065

51_113

101

320.0

Domain

Note=Collagen-like

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Fusion Gene Sequence for ADAMTS12-C1QTNF3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>2041_2041_1_ADAMTS12-C1QTNF3_ADAMTS12_chr5_33891835_ENST00000352040_C1QTNF3_chr5_34035863_ENST00000231338_length(transcript)=1999nt_BP=212nt
TCCTGCTGGGCCACAGGCGAGCGCTTTATTTCTGGAGCTGAGGGCTAAAACTTTTTTGACTTTTCTTCTCCTCAACATCTGAATCATGCC
ATGTGCCCAGAGGAGCTGGCTTGCAAACCTTTCCGTGGTGGCTCAGCTCCTTAACTTTGGGGCGCTTTGCTATGGGAGACAGCCTCAGCC
AGGCCCGGTTCGCTTCCCGGACAGGAGGCAAGTCTCCACAAACCGGAGGACTACCCCCAGACTGCAGTAAGTGTTGTCATGGAGACTACA
GCTTTCGAGGCTACCAAGGCCCCCCTGGGCCACCGGGCCCTCCTGGCATTCCAGGAAACCATGGAAACAATGGCAACAATGGAGCCACTG
GTCATGAAGGAGCCAAAGGTGAGAAGGGCGACAAAGGTGACCTGGGGCCTCGAGGGGAGCGGGGGCAGCATGGCCCCAAAGGAGAGAAGG
GCTACCCGGGGATTCCACCAGAACTTCAGATTGCATTCATGGCTTCTCTGGCAACCCACTTCAGCAATCAGAACAGTGGGATTATCTTCA
GCAGTGTTGAGACCAACATTGGAAACTTCTTTGATGTCATGACTGGTAGATTTGGGGCCCCAGTATCAGGTGTGTATTTCTTCACCTTCA
GCATGATGAAGCATGAGGATGTTGAGGAAGTGTATGTGTACCTTATGCACAATGGCAACACAGTCTTCAGCATGTACAGCTATGAAATGA
AGGGCAAATCAGATACATCCAGCAATCATGCTGTGCTGAAGCTAGCCAAAGGGGATGAGGTTTGGCTGCGAATGGGCAATGGCGCTCTCC
ATGGGGACCACCAACGCTTCTCCACCTTTGCAGGATTCCTGCTCTTTGAAACTAAGTAAATATATGACTAGAATAGCTCCACTTTGGGGA
AGACTTGTAGCTGAGCTGATTTGTTACGATCTGAGGAACATTAAAGTTGAGGGTTTTACATTGCTGTATTCAAAAAATTATTGGTTGCAA
TGTTGTTCACGCTACAGGTACACCAATAATGTTGGACAATTCAGGGGCTCAGAAGAATCAACCACAAAATAGTCTTCTCAGATGACCTTG
ACTAATATACTCAGCATCTTTATCACTCTTTCCTTGGCACCTAAAAGATAATTCTCCTCTGACGCAGGTTGGAAATATTTTTTTCTATCA
CAGAAGTCATTTGCAAAGAATTTTGACTACTCTGCTTTTAATTTAATACCAGTTTTCAGGAACCCCTGAAGTTTTAAGTTCATTATTCTT
TATAACATTTGAGAGAATCGGATGTAGTGATATGACAGGGCTGGGGCAAGAACAGGGGCACTAGCTGCCTTATTAGCTAATTTAGTGCCC
TCCGTGTTCAGCTTAGCCTTTGACCCTTTCCTTTTGATCCACAAAATACATTAAAACTCTGAATTCACATACAATGCTATTTTAAAGTCA
ATAGATTTTAGCTATAAAGTGCTTGACCAGTAATGTGGTTGTAATTTTGTGTATGTTCCCCCACATCGCCCCCAACTTCGGATGTGGGGT
CAGGAGGTTGAGGTTCACTATTAACAAATGTCATAAATATCTCATAGAGGTACAGTGCCAATAGATATTCAAATGTTGCATGTTGACCAG
AGGGATTTTATATCTGAAGAACATACACTATTAATAAATACCTTAGAGAAAGATTTTGACCTGGCTTTAGATAAAACTGTGGCAAGAAAA
ATGTAATGAGCAATATATGGAAATAAACACACCTTTGTTAAAGATACTTTCTAAACTTGTGTTTAATAAACTTTAATAGTCATAGAATTG
TAAATCACTATGGTTAACAGAAAGTGAAAATATTTTCATGCAGATGATGTGAACAGCCATGTGAATAGGTGACTTGGGCACACAGCAGGG
TCATATGACTTCAGAAAACTTCGCTTTTCAGTTATTCCATTGTTATAATGTCAACCCTTTAAGACATTGATGTTTAGAGGGCTCACAAAT
AAAATCTGAATACCTGTAA

>2041_2041_1_ADAMTS12-C1QTNF3_ADAMTS12_chr5_33891835_ENST00000352040_C1QTNF3_chr5_34035863_ENST00000231338_length(amino acids)=252AA_BP=34
MQTFPWWLSSLTLGRFAMGDSLSQARFASRTGGKSPQTGGLPPDCSKCCHGDYSFRGYQGPPGPPGPPGIPGNHGNNGNNGATGHEGAKG
EKGDKGDLGPRGERGQHGPKGEKGYPGIPPELQIAFMASLATHFSNQNSGIIFSSVETNIGNFFDVMTGRFGAPVSGVYFFTFSMMKHED
VEEVYVYLMHNGNTVFSMYSYEMKGKSDTSSNHAVLKLAKGDEVWLRMGNGALHGDHQRFSTFAGFLLFETK

--------------------------------------------------------------
>2041_2041_2_ADAMTS12-C1QTNF3_ADAMTS12_chr5_33891835_ENST00000352040_C1QTNF3_chr5_34035863_ENST00000382065_length(transcript)=2004nt_BP=212nt
TCCTGCTGGGCCACAGGCGAGCGCTTTATTTCTGGAGCTGAGGGCTAAAACTTTTTTGACTTTTCTTCTCCTCAACATCTGAATCATGCC
ATGTGCCCAGAGGAGCTGGCTTGCAAACCTTTCCGTGGTGGCTCAGCTCCTTAACTTTGGGGCGCTTTGCTATGGGAGACAGCCTCAGCC
AGGCCCGGTTCGCTTCCCGGACAGGAGGCAAGTCTCCACAAACCGGAGGACTACCCCCAGACTGCAGTAAGTGTTGTCATGGAGACTACA
GCTTTCGAGGCTACCAAGGCCCCCCTGGGCCACCGGGCCCTCCTGGCATTCCAGGAAACCATGGAAACAATGGCAACAATGGAGCCACTG
GTCATGAAGGAGCCAAAGGTGAGAAGGGCGACAAAGGTGACCTGGGGCCTCGAGGGGAGCGGGGGCAGCATGGCCCCAAAGGAGAGAAGG
GCTACCCGGGGATTCCACCAGAACTTCAGATTGCATTCATGGCTTCTCTGGCAACCCACTTCAGCAATCAGAACAGTGGGATTATCTTCA
GCAGTGTTGAGACCAACATTGGAAACTTCTTTGATGTCATGACTGGTAGATTTGGGGCCCCAGTATCAGGTGTGTATTTCTTCACCTTCA
GCATGATGAAGCATGAGGATGTTGAGGAAGTGTATGTGTACCTTATGCACAATGGCAACACAGTCTTCAGCATGTACAGCTATGAAATGA
AGGGCAAATCAGATACATCCAGCAATCATGCTGTGCTGAAGCTAGCCAAAGGGGATGAGGTTTGGCTGCGAATGGGCAATGGCGCTCTCC
ATGGGGACCACCAACGCTTCTCCACCTTTGCAGGATTCCTGCTCTTTGAAACTAAGTAAATATATGACTAGAATAGCTCCACTTTGGGGA
AGACTTGTAGCTGAGCTGATTTGTTACGATCTGAGGAACATTAAAGTTGAGGGTTTTACATTGCTGTATTCAAAAAATTATTGGTTGCAA
TGTTGTTCACGCTACAGGTACACCAATAATGTTGGACAATTCAGGGGCTCAGAAGAATCAACCACAAAATAGTCTTCTCAGATGACCTTG
ACTAATATACTCAGCATCTTTATCACTCTTTCCTTGGCACCTAAAAGATAATTCTCCTCTGACGCAGGTTGGAAATATTTTTTTCTATCA
CAGAAGTCATTTGCAAAGAATTTTGACTACTCTGCTTTTAATTTAATACCAGTTTTCAGGAACCCCTGAAGTTTTAAGTTCATTATTCTT
TATAACATTTGAGAGAATCGGATGTAGTGATATGACAGGGCTGGGGCAAGAACAGGGGCACTAGCTGCCTTATTAGCTAATTTAGTGCCC
TCCGTGTTCAGCTTAGCCTTTGACCCTTTCCTTTTGATCCACAAAATACATTAAAACTCTGAATTCACATACAATGCTATTTTAAAGTCA
ATAGATTTTAGCTATAAAGTGCTTGACCAGTAATGTGGTTGTAATTTTGTGTATGTTCCCCCACATCGCCCCCAACTTCGGATGTGGGGT
CAGGAGGTTGAGGTTCACTATTAACAAATGTCATAAATATCTCATAGAGGTACAGTGCCAATAGATATTCAAATGTTGCATGTTGACCAG
AGGGATTTTATATCTGAAGAACATACACTATTAATAAATACCTTAGAGAAAGATTTTGACCTGGCTTTAGATAAAACTGTGGCAAGAAAA
ATGTAATGAGCAATATATGGAAATAAACACACCTTTGTTAAAGATACTTTCTAAACTTGTGTTTAATAAACTTTAATAGTCATAGAATTG
TAAATCACTATGGTTAACAGAAAGTGAAAATATTTTCATGCAGATGATGTGAACAGCCATGTGAATAGGTGACTTGGGCACACAGCAGGG
TCATATGACTTCAGAAAACTTCGCTTTTCAGTTATTCCATTGTTATAATGTCAACCCTTTAAGACATTGATGTTTAGAGGGCTCACAAAT
AAAATCTGAATACCTGTAAGGAAA

>2041_2041_2_ADAMTS12-C1QTNF3_ADAMTS12_chr5_33891835_ENST00000352040_C1QTNF3_chr5_34035863_ENST00000382065_length(amino acids)=252AA_BP=34
MQTFPWWLSSLTLGRFAMGDSLSQARFASRTGGKSPQTGGLPPDCSKCCHGDYSFRGYQGPPGPPGPPGIPGNHGNNGNNGATGHEGAKG
EKGDKGDLGPRGERGQHGPKGEKGYPGIPPELQIAFMASLATHFSNQNSGIIFSSVETNIGNFFDVMTGRFGAPVSGVYFFTFSMMKHED
VEEVYVYLMHNGNTVFSMYSYEMKGKSDTSSNHAVLKLAKGDEVWLRMGNGALHGDHQRFSTFAGFLLFETK

--------------------------------------------------------------
>2041_2041_3_ADAMTS12-C1QTNF3_ADAMTS12_chr5_33891835_ENST00000504830_C1QTNF3_chr5_34035863_ENST00000231338_length(transcript)=2250nt_BP=463nt
GAGCGGGCGGGCTGCGAGGCCGCGGGGCATGCGGGAGGCGGAGGGGTGGGGACCGGGGTGGGCTGCGCCCTCCCGCTCTGGCCCATTCCA
CACCCCGCCGAAAGCGGACACTGTCAGCTGAATCACTCCCCTTTTAGGAGGAGGGAGGGGAAAAAGGTGTCTAGCTCCTTTCTGCTTAAA
AAAGCACAGGGAGATCGCGGGCAGCTTTGCAGTCGCTGCCTTCTCGCGCCTGACCATGCACCCCTGCATCTTCCTGCTGGGCCACAGGCG
AGCGCTTTATTTCTGGAGCTGAGGGCTAAAACTTTTTTGACTTTTCTTCTCCTCAACATCTGAATCATGCCATGTGCCCAGAGGAGCTGG
CTTGCAAACCTTTCCGTGGTGGCTCAGCTCCTTAACTTTGGGGCGCTTTGCTATGGGAGACAGCCTCAGCCAGGCCCGGTTCGCTTCCCG
GACAGGAGGCAAGTCTCCACAAACCGGAGGACTACCCCCAGACTGCAGTAAGTGTTGTCATGGAGACTACAGCTTTCGAGGCTACCAAGG
CCCCCCTGGGCCACCGGGCCCTCCTGGCATTCCAGGAAACCATGGAAACAATGGCAACAATGGAGCCACTGGTCATGAAGGAGCCAAAGG
TGAGAAGGGCGACAAAGGTGACCTGGGGCCTCGAGGGGAGCGGGGGCAGCATGGCCCCAAAGGAGAGAAGGGCTACCCGGGGATTCCACC
AGAACTTCAGATTGCATTCATGGCTTCTCTGGCAACCCACTTCAGCAATCAGAACAGTGGGATTATCTTCAGCAGTGTTGAGACCAACAT
TGGAAACTTCTTTGATGTCATGACTGGTAGATTTGGGGCCCCAGTATCAGGTGTGTATTTCTTCACCTTCAGCATGATGAAGCATGAGGA
TGTTGAGGAAGTGTATGTGTACCTTATGCACAATGGCAACACAGTCTTCAGCATGTACAGCTATGAAATGAAGGGCAAATCAGATACATC
CAGCAATCATGCTGTGCTGAAGCTAGCCAAAGGGGATGAGGTTTGGCTGCGAATGGGCAATGGCGCTCTCCATGGGGACCACCAACGCTT
CTCCACCTTTGCAGGATTCCTGCTCTTTGAAACTAAGTAAATATATGACTAGAATAGCTCCACTTTGGGGAAGACTTGTAGCTGAGCTGA
TTTGTTACGATCTGAGGAACATTAAAGTTGAGGGTTTTACATTGCTGTATTCAAAAAATTATTGGTTGCAATGTTGTTCACGCTACAGGT
ACACCAATAATGTTGGACAATTCAGGGGCTCAGAAGAATCAACCACAAAATAGTCTTCTCAGATGACCTTGACTAATATACTCAGCATCT
TTATCACTCTTTCCTTGGCACCTAAAAGATAATTCTCCTCTGACGCAGGTTGGAAATATTTTTTTCTATCACAGAAGTCATTTGCAAAGA
ATTTTGACTACTCTGCTTTTAATTTAATACCAGTTTTCAGGAACCCCTGAAGTTTTAAGTTCATTATTCTTTATAACATTTGAGAGAATC
GGATGTAGTGATATGACAGGGCTGGGGCAAGAACAGGGGCACTAGCTGCCTTATTAGCTAATTTAGTGCCCTCCGTGTTCAGCTTAGCCT
TTGACCCTTTCCTTTTGATCCACAAAATACATTAAAACTCTGAATTCACATACAATGCTATTTTAAAGTCAATAGATTTTAGCTATAAAG
TGCTTGACCAGTAATGTGGTTGTAATTTTGTGTATGTTCCCCCACATCGCCCCCAACTTCGGATGTGGGGTCAGGAGGTTGAGGTTCACT
ATTAACAAATGTCATAAATATCTCATAGAGGTACAGTGCCAATAGATATTCAAATGTTGCATGTTGACCAGAGGGATTTTATATCTGAAG
AACATACACTATTAATAAATACCTTAGAGAAAGATTTTGACCTGGCTTTAGATAAAACTGTGGCAAGAAAAATGTAATGAGCAATATATG
GAAATAAACACACCTTTGTTAAAGATACTTTCTAAACTTGTGTTTAATAAACTTTAATAGTCATAGAATTGTAAATCACTATGGTTAACA
GAAAGTGAAAATATTTTCATGCAGATGATGTGAACAGCCATGTGAATAGGTGACTTGGGCACACAGCAGGGTCATATGACTTCAGAAAAC
TTCGCTTTTCAGTTATTCCATTGTTATAATGTCAACCCTTTAAGACATTGATGTTTAGAGGGCTCACAAATAAAATCTGAATACCTGTAA

>2041_2041_3_ADAMTS12-C1QTNF3_ADAMTS12_chr5_33891835_ENST00000504830_C1QTNF3_chr5_34035863_ENST00000231338_length(amino acids)=252AA_BP=34
MQTFPWWLSSLTLGRFAMGDSLSQARFASRTGGKSPQTGGLPPDCSKCCHGDYSFRGYQGPPGPPGPPGIPGNHGNNGNNGATGHEGAKG
EKGDKGDLGPRGERGQHGPKGEKGYPGIPPELQIAFMASLATHFSNQNSGIIFSSVETNIGNFFDVMTGRFGAPVSGVYFFTFSMMKHED
VEEVYVYLMHNGNTVFSMYSYEMKGKSDTSSNHAVLKLAKGDEVWLRMGNGALHGDHQRFSTFAGFLLFETK

--------------------------------------------------------------
>2041_2041_4_ADAMTS12-C1QTNF3_ADAMTS12_chr5_33891835_ENST00000504830_C1QTNF3_chr5_34035863_ENST00000382065_length(transcript)=2255nt_BP=463nt
GAGCGGGCGGGCTGCGAGGCCGCGGGGCATGCGGGAGGCGGAGGGGTGGGGACCGGGGTGGGCTGCGCCCTCCCGCTCTGGCCCATTCCA
CACCCCGCCGAAAGCGGACACTGTCAGCTGAATCACTCCCCTTTTAGGAGGAGGGAGGGGAAAAAGGTGTCTAGCTCCTTTCTGCTTAAA
AAAGCACAGGGAGATCGCGGGCAGCTTTGCAGTCGCTGCCTTCTCGCGCCTGACCATGCACCCCTGCATCTTCCTGCTGGGCCACAGGCG
AGCGCTTTATTTCTGGAGCTGAGGGCTAAAACTTTTTTGACTTTTCTTCTCCTCAACATCTGAATCATGCCATGTGCCCAGAGGAGCTGG
CTTGCAAACCTTTCCGTGGTGGCTCAGCTCCTTAACTTTGGGGCGCTTTGCTATGGGAGACAGCCTCAGCCAGGCCCGGTTCGCTTCCCG
GACAGGAGGCAAGTCTCCACAAACCGGAGGACTACCCCCAGACTGCAGTAAGTGTTGTCATGGAGACTACAGCTTTCGAGGCTACCAAGG
CCCCCCTGGGCCACCGGGCCCTCCTGGCATTCCAGGAAACCATGGAAACAATGGCAACAATGGAGCCACTGGTCATGAAGGAGCCAAAGG
TGAGAAGGGCGACAAAGGTGACCTGGGGCCTCGAGGGGAGCGGGGGCAGCATGGCCCCAAAGGAGAGAAGGGCTACCCGGGGATTCCACC
AGAACTTCAGATTGCATTCATGGCTTCTCTGGCAACCCACTTCAGCAATCAGAACAGTGGGATTATCTTCAGCAGTGTTGAGACCAACAT
TGGAAACTTCTTTGATGTCATGACTGGTAGATTTGGGGCCCCAGTATCAGGTGTGTATTTCTTCACCTTCAGCATGATGAAGCATGAGGA
TGTTGAGGAAGTGTATGTGTACCTTATGCACAATGGCAACACAGTCTTCAGCATGTACAGCTATGAAATGAAGGGCAAATCAGATACATC
CAGCAATCATGCTGTGCTGAAGCTAGCCAAAGGGGATGAGGTTTGGCTGCGAATGGGCAATGGCGCTCTCCATGGGGACCACCAACGCTT
CTCCACCTTTGCAGGATTCCTGCTCTTTGAAACTAAGTAAATATATGACTAGAATAGCTCCACTTTGGGGAAGACTTGTAGCTGAGCTGA
TTTGTTACGATCTGAGGAACATTAAAGTTGAGGGTTTTACATTGCTGTATTCAAAAAATTATTGGTTGCAATGTTGTTCACGCTACAGGT
ACACCAATAATGTTGGACAATTCAGGGGCTCAGAAGAATCAACCACAAAATAGTCTTCTCAGATGACCTTGACTAATATACTCAGCATCT
TTATCACTCTTTCCTTGGCACCTAAAAGATAATTCTCCTCTGACGCAGGTTGGAAATATTTTTTTCTATCACAGAAGTCATTTGCAAAGA
ATTTTGACTACTCTGCTTTTAATTTAATACCAGTTTTCAGGAACCCCTGAAGTTTTAAGTTCATTATTCTTTATAACATTTGAGAGAATC
GGATGTAGTGATATGACAGGGCTGGGGCAAGAACAGGGGCACTAGCTGCCTTATTAGCTAATTTAGTGCCCTCCGTGTTCAGCTTAGCCT
TTGACCCTTTCCTTTTGATCCACAAAATACATTAAAACTCTGAATTCACATACAATGCTATTTTAAAGTCAATAGATTTTAGCTATAAAG
TGCTTGACCAGTAATGTGGTTGTAATTTTGTGTATGTTCCCCCACATCGCCCCCAACTTCGGATGTGGGGTCAGGAGGTTGAGGTTCACT
ATTAACAAATGTCATAAATATCTCATAGAGGTACAGTGCCAATAGATATTCAAATGTTGCATGTTGACCAGAGGGATTTTATATCTGAAG
AACATACACTATTAATAAATACCTTAGAGAAAGATTTTGACCTGGCTTTAGATAAAACTGTGGCAAGAAAAATGTAATGAGCAATATATG
GAAATAAACACACCTTTGTTAAAGATACTTTCTAAACTTGTGTTTAATAAACTTTAATAGTCATAGAATTGTAAATCACTATGGTTAACA
GAAAGTGAAAATATTTTCATGCAGATGATGTGAACAGCCATGTGAATAGGTGACTTGGGCACACAGCAGGGTCATATGACTTCAGAAAAC
TTCGCTTTTCAGTTATTCCATTGTTATAATGTCAACCCTTTAAGACATTGATGTTTAGAGGGCTCACAAATAAAATCTGAATACCTGTAA
GGAAA

>2041_2041_4_ADAMTS12-C1QTNF3_ADAMTS12_chr5_33891835_ENST00000504830_C1QTNF3_chr5_34035863_ENST00000382065_length(amino acids)=252AA_BP=34
MQTFPWWLSSLTLGRFAMGDSLSQARFASRTGGKSPQTGGLPPDCSKCCHGDYSFRGYQGPPGPPGPPGIPGNHGNNGNNGATGHEGAKG
EKGDKGDLGPRGERGQHGPKGEKGYPGIPPELQIAFMASLATHFSNQNSGIIFSSVETNIGNFFDVMTGRFGAPVSGVYFFTFSMMKHED
VEEVYVYLMHNGNTVFSMYSYEMKGKSDTSSNHAVLKLAKGDEVWLRMGNGALHGDHQRFSTFAGFLLFETK

--------------------------------------------------------------
>2041_2041_5_ADAMTS12-C1QTNF3_ADAMTS12_chr5_33891835_ENST00000515401_C1QTNF3_chr5_34035863_ENST00000231338_length(transcript)=2077nt_BP=290nt
GCTTAAAAAAGCACAGGGAGATCGCGGGCAGCTTTGCAGTCGCTGCCTTCTCGCGCCTGACCATGCACCCCTGCATCTTCCTGCTGGGCC
ACAGGCGAGCGCTTTATTTCTGGAGCTGAGGGCTAAAACTTTTTTGACTTTTCTTCTCCTCAACATCTGAATCATGCCATGTGCCCAGAG
GAGCTGGCTTGCAAACCTTTCCGTGGTGGCTCAGCTCCTTAACTTTGGGGCGCTTTGCTATGGGAGACAGCCTCAGCCAGGCCCGGTTCG
CTTCCCGGACAGGAGGCAAGTCTCCACAAACCGGAGGACTACCCCCAGACTGCAGTAAGTGTTGTCATGGAGACTACAGCTTTCGAGGCT
ACCAAGGCCCCCCTGGGCCACCGGGCCCTCCTGGCATTCCAGGAAACCATGGAAACAATGGCAACAATGGAGCCACTGGTCATGAAGGAG
CCAAAGGTGAGAAGGGCGACAAAGGTGACCTGGGGCCTCGAGGGGAGCGGGGGCAGCATGGCCCCAAAGGAGAGAAGGGCTACCCGGGGA
TTCCACCAGAACTTCAGATTGCATTCATGGCTTCTCTGGCAACCCACTTCAGCAATCAGAACAGTGGGATTATCTTCAGCAGTGTTGAGA
CCAACATTGGAAACTTCTTTGATGTCATGACTGGTAGATTTGGGGCCCCAGTATCAGGTGTGTATTTCTTCACCTTCAGCATGATGAAGC
ATGAGGATGTTGAGGAAGTGTATGTGTACCTTATGCACAATGGCAACACAGTCTTCAGCATGTACAGCTATGAAATGAAGGGCAAATCAG
ATACATCCAGCAATCATGCTGTGCTGAAGCTAGCCAAAGGGGATGAGGTTTGGCTGCGAATGGGCAATGGCGCTCTCCATGGGGACCACC
AACGCTTCTCCACCTTTGCAGGATTCCTGCTCTTTGAAACTAAGTAAATATATGACTAGAATAGCTCCACTTTGGGGAAGACTTGTAGCT
GAGCTGATTTGTTACGATCTGAGGAACATTAAAGTTGAGGGTTTTACATTGCTGTATTCAAAAAATTATTGGTTGCAATGTTGTTCACGC
TACAGGTACACCAATAATGTTGGACAATTCAGGGGCTCAGAAGAATCAACCACAAAATAGTCTTCTCAGATGACCTTGACTAATATACTC
AGCATCTTTATCACTCTTTCCTTGGCACCTAAAAGATAATTCTCCTCTGACGCAGGTTGGAAATATTTTTTTCTATCACAGAAGTCATTT
GCAAAGAATTTTGACTACTCTGCTTTTAATTTAATACCAGTTTTCAGGAACCCCTGAAGTTTTAAGTTCATTATTCTTTATAACATTTGA
GAGAATCGGATGTAGTGATATGACAGGGCTGGGGCAAGAACAGGGGCACTAGCTGCCTTATTAGCTAATTTAGTGCCCTCCGTGTTCAGC
TTAGCCTTTGACCCTTTCCTTTTGATCCACAAAATACATTAAAACTCTGAATTCACATACAATGCTATTTTAAAGTCAATAGATTTTAGC
TATAAAGTGCTTGACCAGTAATGTGGTTGTAATTTTGTGTATGTTCCCCCACATCGCCCCCAACTTCGGATGTGGGGTCAGGAGGTTGAG
GTTCACTATTAACAAATGTCATAAATATCTCATAGAGGTACAGTGCCAATAGATATTCAAATGTTGCATGTTGACCAGAGGGATTTTATA
TCTGAAGAACATACACTATTAATAAATACCTTAGAGAAAGATTTTGACCTGGCTTTAGATAAAACTGTGGCAAGAAAAATGTAATGAGCA
ATATATGGAAATAAACACACCTTTGTTAAAGATACTTTCTAAACTTGTGTTTAATAAACTTTAATAGTCATAGAATTGTAAATCACTATG
GTTAACAGAAAGTGAAAATATTTTCATGCAGATGATGTGAACAGCCATGTGAATAGGTGACTTGGGCACACAGCAGGGTCATATGACTTC
AGAAAACTTCGCTTTTCAGTTATTCCATTGTTATAATGTCAACCCTTTAAGACATTGATGTTTAGAGGGCTCACAAATAAAATCTGAATA
CCTGTAA

>2041_2041_5_ADAMTS12-C1QTNF3_ADAMTS12_chr5_33891835_ENST00000515401_C1QTNF3_chr5_34035863_ENST00000231338_length(amino acids)=252AA_BP=34
MQTFPWWLSSLTLGRFAMGDSLSQARFASRTGGKSPQTGGLPPDCSKCCHGDYSFRGYQGPPGPPGPPGIPGNHGNNGNNGATGHEGAKG
EKGDKGDLGPRGERGQHGPKGEKGYPGIPPELQIAFMASLATHFSNQNSGIIFSSVETNIGNFFDVMTGRFGAPVSGVYFFTFSMMKHED
VEEVYVYLMHNGNTVFSMYSYEMKGKSDTSSNHAVLKLAKGDEVWLRMGNGALHGDHQRFSTFAGFLLFETK

--------------------------------------------------------------
>2041_2041_6_ADAMTS12-C1QTNF3_ADAMTS12_chr5_33891835_ENST00000515401_C1QTNF3_chr5_34035863_ENST00000382065_length(transcript)=2082nt_BP=290nt
GCTTAAAAAAGCACAGGGAGATCGCGGGCAGCTTTGCAGTCGCTGCCTTCTCGCGCCTGACCATGCACCCCTGCATCTTCCTGCTGGGCC
ACAGGCGAGCGCTTTATTTCTGGAGCTGAGGGCTAAAACTTTTTTGACTTTTCTTCTCCTCAACATCTGAATCATGCCATGTGCCCAGAG
GAGCTGGCTTGCAAACCTTTCCGTGGTGGCTCAGCTCCTTAACTTTGGGGCGCTTTGCTATGGGAGACAGCCTCAGCCAGGCCCGGTTCG
CTTCCCGGACAGGAGGCAAGTCTCCACAAACCGGAGGACTACCCCCAGACTGCAGTAAGTGTTGTCATGGAGACTACAGCTTTCGAGGCT
ACCAAGGCCCCCCTGGGCCACCGGGCCCTCCTGGCATTCCAGGAAACCATGGAAACAATGGCAACAATGGAGCCACTGGTCATGAAGGAG
CCAAAGGTGAGAAGGGCGACAAAGGTGACCTGGGGCCTCGAGGGGAGCGGGGGCAGCATGGCCCCAAAGGAGAGAAGGGCTACCCGGGGA
TTCCACCAGAACTTCAGATTGCATTCATGGCTTCTCTGGCAACCCACTTCAGCAATCAGAACAGTGGGATTATCTTCAGCAGTGTTGAGA
CCAACATTGGAAACTTCTTTGATGTCATGACTGGTAGATTTGGGGCCCCAGTATCAGGTGTGTATTTCTTCACCTTCAGCATGATGAAGC
ATGAGGATGTTGAGGAAGTGTATGTGTACCTTATGCACAATGGCAACACAGTCTTCAGCATGTACAGCTATGAAATGAAGGGCAAATCAG
ATACATCCAGCAATCATGCTGTGCTGAAGCTAGCCAAAGGGGATGAGGTTTGGCTGCGAATGGGCAATGGCGCTCTCCATGGGGACCACC
AACGCTTCTCCACCTTTGCAGGATTCCTGCTCTTTGAAACTAAGTAAATATATGACTAGAATAGCTCCACTTTGGGGAAGACTTGTAGCT
GAGCTGATTTGTTACGATCTGAGGAACATTAAAGTTGAGGGTTTTACATTGCTGTATTCAAAAAATTATTGGTTGCAATGTTGTTCACGC
TACAGGTACACCAATAATGTTGGACAATTCAGGGGCTCAGAAGAATCAACCACAAAATAGTCTTCTCAGATGACCTTGACTAATATACTC
AGCATCTTTATCACTCTTTCCTTGGCACCTAAAAGATAATTCTCCTCTGACGCAGGTTGGAAATATTTTTTTCTATCACAGAAGTCATTT
GCAAAGAATTTTGACTACTCTGCTTTTAATTTAATACCAGTTTTCAGGAACCCCTGAAGTTTTAAGTTCATTATTCTTTATAACATTTGA
GAGAATCGGATGTAGTGATATGACAGGGCTGGGGCAAGAACAGGGGCACTAGCTGCCTTATTAGCTAATTTAGTGCCCTCCGTGTTCAGC
TTAGCCTTTGACCCTTTCCTTTTGATCCACAAAATACATTAAAACTCTGAATTCACATACAATGCTATTTTAAAGTCAATAGATTTTAGC
TATAAAGTGCTTGACCAGTAATGTGGTTGTAATTTTGTGTATGTTCCCCCACATCGCCCCCAACTTCGGATGTGGGGTCAGGAGGTTGAG
GTTCACTATTAACAAATGTCATAAATATCTCATAGAGGTACAGTGCCAATAGATATTCAAATGTTGCATGTTGACCAGAGGGATTTTATA
TCTGAAGAACATACACTATTAATAAATACCTTAGAGAAAGATTTTGACCTGGCTTTAGATAAAACTGTGGCAAGAAAAATGTAATGAGCA
ATATATGGAAATAAACACACCTTTGTTAAAGATACTTTCTAAACTTGTGTTTAATAAACTTTAATAGTCATAGAATTGTAAATCACTATG
GTTAACAGAAAGTGAAAATATTTTCATGCAGATGATGTGAACAGCCATGTGAATAGGTGACTTGGGCACACAGCAGGGTCATATGACTTC
AGAAAACTTCGCTTTTCAGTTATTCCATTGTTATAATGTCAACCCTTTAAGACATTGATGTTTAGAGGGCTCACAAATAAAATCTGAATA
CCTGTAAGGAAA

>2041_2041_6_ADAMTS12-C1QTNF3_ADAMTS12_chr5_33891835_ENST00000515401_C1QTNF3_chr5_34035863_ENST00000382065_length(amino acids)=252AA_BP=34
MQTFPWWLSSLTLGRFAMGDSLSQARFASRTGGKSPQTGGLPPDCSKCCHGDYSFRGYQGPPGPPGPPGIPGNHGNNGNNGATGHEGAKG
EKGDKGDLGPRGERGQHGPKGEKGYPGIPPELQIAFMASLATHFSNQNSGIIFSSVETNIGNFFDVMTGRFGAPVSGVYFFTFSMMKHED
VEEVYVYLMHNGNTVFSMYSYEMKGKSDTSSNHAVLKLAKGDEVWLRMGNGALHGDHQRFSTFAGFLLFETK

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ADAMTS12-C1QTNF3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ADAMTS12-C1QTNF3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ADAMTS12-C1QTNF3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	ADAMTS12	C0036341	Schizophrenia	1	PSYGENET

Fusion Gene Studies in Kim Lab

Fusion gene:ADAMTS12-C1QTNF3 (FusionGDB2 ID:HG81792TG114899)

Fusion Gene Summary for ADAMTS12-C1QTNF3

Fusion Gene ORF analysis for ADAMTS12-C1QTNF3

Fusion Genomic Features for ADAMTS12-C1QTNF3

Fusion Protein Features for ADAMTS12-C1QTNF3

Fusion Gene Sequence for ADAMTS12-C1QTNF3

Fusion Gene PPI Analysis for ADAMTS12-C1QTNF3

Related Drugs for ADAMTS12-C1QTNF3

Related Diseases for ADAMTS12-C1QTNF3

Fusion Gene Studies
in Kim Lab