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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ABHD17A-GSTP1 (FusionGDB2 ID:HG81926TG2950) |
Fusion Gene Summary for ABHD17A-GSTP1 |
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Fusion gene information | Fusion gene name: ABHD17A-GSTP1 | Fusion gene ID: hg81926tg2950 | Hgene | Tgene | Gene symbol | ABHD17A | GSTP1 | Gene ID | 81926 | 2950 |
Gene name | abhydrolase domain containing 17A, depalmitoylase | glutathione S-transferase pi 1 | |
Synonyms | C19orf27|FAM108A1 | DFN7|FAEES3|GST3|GSTP|HEL-S-22|PI | |
Cytomap | ('ABHD17A')('GSTP1') 19p13.3 | 11q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | alpha/beta hydrolase domain-containing protein 17Aabhydrolase domain containing 17Aabhydrolase domain-containing protein 17Aabhydrolase domain-containing protein FAM108A1family with sequence similarity 108, member A1protein ABHD17A | glutathione S-transferase PGST class-piGSTP1-1deafness, X-linked 7epididymis secretory protein Li 22fatty acid ethyl ester synthase III | |
Modification date | 20200313 | 20200329 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000250974, ENST00000292577, ENST00000590661, | ||
Fusion gene scores | * DoF score | 6 X 4 X 6=144 | 5 X 4 X 5=100 |
# samples | 6 | 5 | |
** MAII score | log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ABHD17A [Title/Abstract] AND GSTP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ABHD17A(1881404)-GSTP1(67352611), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | GSTP1 | GO:0006469 | negative regulation of protein kinase activity | 16636664 |
Tgene | GSTP1 | GO:0006749 | glutathione metabolic process | 1540159 |
Tgene | GSTP1 | GO:0006805 | xenobiotic metabolic process | 1540159 |
Tgene | GSTP1 | GO:0009890 | negative regulation of biosynthetic process | 18962899 |
Tgene | GSTP1 | GO:0032691 | negative regulation of interleukin-1 beta production | 18962899 |
Tgene | GSTP1 | GO:0032720 | negative regulation of tumor necrosis factor production | 18962899 |
Tgene | GSTP1 | GO:0043407 | negative regulation of MAP kinase activity | 11408560 |
Tgene | GSTP1 | GO:0043508 | negative regulation of JUN kinase activity | 16636664 |
Tgene | GSTP1 | GO:0043651 | linoleic acid metabolic process | 16624487 |
Tgene | GSTP1 | GO:0051771 | negative regulation of nitric-oxide synthase biosynthetic process | 18962899 |
Tgene | GSTP1 | GO:0070373 | negative regulation of ERK1 and ERK2 cascade | 11408560 |
Tgene | GSTP1 | GO:0071638 | negative regulation of monocyte chemotactic protein-1 production | 18962899 |
Tgene | GSTP1 | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway | 16636664 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | COAD | TCGA-AA-A01D-01A | ABHD17A | chr19 | 1881404 | - | GSTP1 | chr11 | 67352611 | + |
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Fusion Gene ORF analysis for ABHD17A-GSTP1 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000250974 | ENST00000398603 | ABHD17A | chr19 | 1881404 | - | GSTP1 | chr11 | 67352611 | + |
intron-3CDS | ENST00000250974 | ENST00000398606 | ABHD17A | chr19 | 1881404 | - | GSTP1 | chr11 | 67352611 | + |
intron-3CDS | ENST00000292577 | ENST00000398603 | ABHD17A | chr19 | 1881404 | - | GSTP1 | chr11 | 67352611 | + |
intron-3CDS | ENST00000292577 | ENST00000398606 | ABHD17A | chr19 | 1881404 | - | GSTP1 | chr11 | 67352611 | + |
intron-3CDS | ENST00000590661 | ENST00000398603 | ABHD17A | chr19 | 1881404 | - | GSTP1 | chr11 | 67352611 | + |
intron-3CDS | ENST00000590661 | ENST00000398606 | ABHD17A | chr19 | 1881404 | - | GSTP1 | chr11 | 67352611 | + |
intron-3UTR | ENST00000250974 | ENST00000498765 | ABHD17A | chr19 | 1881404 | - | GSTP1 | chr11 | 67352611 | + |
intron-3UTR | ENST00000292577 | ENST00000498765 | ABHD17A | chr19 | 1881404 | - | GSTP1 | chr11 | 67352611 | + |
intron-3UTR | ENST00000590661 | ENST00000498765 | ABHD17A | chr19 | 1881404 | - | GSTP1 | chr11 | 67352611 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for ABHD17A-GSTP1 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for ABHD17A-GSTP1 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:1881404/:67352611) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for ABHD17A-GSTP1 |
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Fusion Gene PPI Analysis for ABHD17A-GSTP1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ABHD17A-GSTP1 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ABHD17A-GSTP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | C0032927 | Precancerous Conditions | 6 | CTD_human | |
Tgene | C0282313 | Condition, Preneoplastic | 6 | CTD_human | |
Tgene | C0033578 | Prostatic Neoplasms | 5 | CTD_human | |
Tgene | C0376358 | Malignant neoplasm of prostate | 5 | CTD_human | |
Tgene | C0004096 | Asthma | 4 | CTD_human | |
Tgene | C0019207 | Hepatoma, Morris | 4 | CTD_human | |
Tgene | C0019208 | Hepatoma, Novikoff | 4 | CTD_human | |
Tgene | C0023904 | Liver Neoplasms, Experimental | 4 | CTD_human | |
Tgene | C0086404 | Experimental Hepatoma | 4 | CTD_human | |
Tgene | C0005684 | Malignant neoplasm of urinary bladder | 3 | CTD_human | |
Tgene | C0005695 | Bladder Neoplasm | 3 | CTD_human | |
Tgene | C0019193 | Hepatitis, Toxic | 2 | CTD_human | |
Tgene | C0024623 | Malignant neoplasm of stomach | 2 | CTD_human | |
Tgene | C0030567 | Parkinson Disease | 2 | CTD_human | |
Tgene | C0036341 | Schizophrenia | 2 | PSYGENET | |
Tgene | C0038356 | Stomach Neoplasms | 2 | CTD_human | |
Tgene | C0860207 | Drug-Induced Liver Disease | 2 | CTD_human | |
Tgene | C1262760 | Hepatitis, Drug-Induced | 2 | CTD_human | |
Tgene | C1708349 | Hereditary Diffuse Gastric Cancer | 2 | CTD_human | |
Tgene | C3658290 | Drug-Induced Acute Liver Injury | 2 | CTD_human | |
Tgene | C4277682 | Chemical and Drug Induced Liver Injury | 2 | CTD_human | |
Tgene | C4279912 | Chemically-Induced Liver Toxicity | 2 | CTD_human | |
Tgene | C0002736 | Amyotrophic Lateral Sclerosis | 1 | CTD_human | |
Tgene | C0004352 | Autistic Disorder | 1 | CTD_human | |
Tgene | C0004403 | Autosome Abnormalities | 1 | CTD_human | |
Tgene | C0006142 | Malignant neoplasm of breast | 1 | CTD_human | |
Tgene | C0007097 | Carcinoma | 1 | CTD_human | |
Tgene | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human | |
Tgene | C0007134 | Renal Cell Carcinoma | 1 | CTD_human | |
Tgene | C0007273 | Carotid Artery Diseases | 1 | CTD_human | |
Tgene | C0008625 | Chromosome Aberrations | 1 | CTD_human | |
Tgene | C0011616 | Contact Dermatitis | 1 | CTD_human | |
Tgene | C0013182 | Drug Allergy | 1 | CTD_human | |
Tgene | C0017638 | Glioma | 1 | CTD_human | |
Tgene | C0019829 | Hodgkin Disease | 1 | CTD_human | |
Tgene | C0020538 | Hypertensive disease | 1 | CTD_human | |
Tgene | C0022650 | Kidney Calculi | 1 | CTD_human | |
Tgene | C0022658 | Kidney Diseases | 1 | CTD_human | |
Tgene | C0022660 | Kidney Failure, Acute | 1 | CTD_human | |
Tgene | C0023473 | Myeloid Leukemia, Chronic | 1 | CTD_human | |
Tgene | C0024121 | Lung Neoplasms | 1 | CTD_human | |
Tgene | C0027540 | Necrosis | 1 | CTD_human | |
Tgene | C0029463 | Osteosarcoma | 1 | CTD_human | |
Tgene | C0032230 | Pleural Rub | 1 | CTD_human | |
Tgene | C0033937 | Psychoses, Drug | 1 | CTD_human | |
Tgene | C0033941 | Psychoses, Substance-Induced | 1 | CTD_human | |
Tgene | C0033975 | Psychotic Disorders | 1 | PSYGENET | |
Tgene | C0034642 | Rales | 1 | CTD_human | |
Tgene | C0035234 | Respiratory Sounds | 1 | CTD_human | |
Tgene | C0035508 | Rhonchi | 1 | CTD_human | |
Tgene | C0036939 | Shared Paranoid Disorder | 1 | PSYGENET | |
Tgene | C0038450 | Stridor | 1 | CTD_human | |
Tgene | C0042594 | Vestibular Diseases | 1 | CTD_human | |
Tgene | C0043144 | Wheezing | 1 | CTD_human | |
Tgene | C0151744 | Myocardial Ischemia | 1 | CTD_human | |
Tgene | C0152266 | Mixed Cellularity Hodgkin Lymphoma | 1 | CTD_human | |
Tgene | C0152267 | Hodgkin lymphoma, lymphocyte depletion | 1 | CTD_human | |
Tgene | C0162351 | Contact hypersensitivity | 1 | CTD_human | |
Tgene | C0205696 | Anaplastic carcinoma | 1 | CTD_human | |
Tgene | C0205697 | Carcinoma, Spindle-Cell | 1 | CTD_human | |
Tgene | C0205698 | Undifferentiated carcinoma | 1 | CTD_human | |
Tgene | C0205699 | Carcinomatosis | 1 | CTD_human | |
Tgene | C0205944 | Sarcoma, Epithelioid | 1 | CTD_human | |
Tgene | C0205945 | Sarcoma, Spindle Cell | 1 | CTD_human | |
Tgene | C0220597 | Adult Hodgkin Lymphoma | 1 | CTD_human | |
Tgene | C0235874 | Disease Exacerbation | 1 | CTD_human | |
Tgene | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human | |
Tgene | C0236804 | Amphetamine Addiction | 1 | CTD_human | |
Tgene | C0236807 | Amphetamine Abuse | 1 | CTD_human | |
Tgene | C0242379 | Malignant neoplasm of lung | 1 | CTD_human | |
Tgene | C0259783 | mixed gliomas | 1 | CTD_human | |
Tgene | C0270736 | Essential Tremor | 1 | CTD_human | |
Tgene | C0279702 | Conventional (Clear Cell) Renal Cell Carcinoma | 1 | CTD_human | |
Tgene | C0282612 | Prostatic Intraepithelial Neoplasias | 1 | CTD_human | |
Tgene | C0349204 | Nonorganic psychosis | 1 | PSYGENET | |
Tgene | C0393554 | Amyotrophic Lateral Sclerosis With Dementia | 1 | CTD_human | |
Tgene | C0393615 | Familial Tremor | 1 | CTD_human | |
Tgene | C0400966 | Non-alcoholic Fatty Liver Disease | 1 | CTD_human | |
Tgene | C0543859 | Amyotrophic Lateral Sclerosis, Guam Form | 1 | CTD_human | |
Tgene | C0555198 | Malignant Glioma | 1 | CTD_human | |
Tgene | C0577631 | Carotid Atherosclerosis | 1 | CTD_human | |
Tgene | C0600178 | External Carotid Artery Diseases | 1 | CTD_human | |
Tgene | C0600427 | Cocaine Dependence | 1 | PSYGENET | |
Tgene | C0678222 | Breast Carcinoma | 1 | CTD_human | |
Tgene | C0750986 | Internal Carotid Artery Diseases | 1 | CTD_human | |
Tgene | C0750987 | Arterial Diseases, Common Carotid | 1 | CTD_human | |
Tgene | C0948089 | Acute Coronary Syndrome | 1 | CTD_human | |
Tgene | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human | |
Tgene | C1261473 | Sarcoma | 1 | CTD_human | |
Tgene | C1266042 | Chromophobe Renal Cell Carcinoma | 1 | CTD_human | |
Tgene | C1266043 | Sarcomatoid Renal Cell Carcinoma | 1 | CTD_human | |
Tgene | C1266044 | Collecting Duct Carcinoma of the Kidney | 1 | CTD_human | |
Tgene | C1266194 | Lymphocyte Rich Classical Hodgkin Lymphoma | 1 | CTD_human | |
Tgene | C1306837 | Papillary Renal Cell Carcinoma | 1 | CTD_human | |
Tgene | C1334968 | Nodular Lymphocyte Predominant Hodgkin Lymphoma | 1 | CTD_human | |
Tgene | C1456865 | Ureteral Calculi | 1 | CTD_human | |
Tgene | C1458155 | Mammary Neoplasms | 1 | CTD_human | |
Tgene | C1565662 | Acute Kidney Insufficiency | 1 | CTD_human | |
Tgene | C2239176 | Liver carcinoma | 1 | CTD_human | |
Tgene | C2609414 | Acute kidney injury | 1 | CTD_human | |
Tgene | C3241937 | Nonalcoholic Steatohepatitis | 1 | CTD_human | |
Tgene | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human | |
Tgene | C4721453 | Peripheral Nervous System Diseases | 1 | CTD_human |