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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NRIP1-ZNF573 (FusionGDB2 ID:HG8204TG126231)

Fusion Gene Summary for NRIP1-ZNF573

check button Fusion gene summary
Fusion gene informationFusion gene name: NRIP1-ZNF573
Fusion gene ID: hg8204tg126231
HgeneTgene
Gene symbol

NRIP1

ZNF573

Gene ID

8204

126231

Gene namenuclear receptor interacting protein 1zinc finger protein 573
SynonymsCAKUT3|RIP140-
Cytomap('NRIP1')('ZNF573')

21q11.2-q21.1

19q13.12

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor-interacting protein 1nuclear factor RIP140receptor-interacting protein 140zinc finger protein 573
Modification date2020031320200313
UniProtAcc

P48552

.
Ensembl transtripts involved in fusion geneENST00000318948, ENST00000400199, 
ENST00000400202, 
Fusion gene scores* DoF score20 X 10 X 12=24003 X 2 X 3=18
# samples 264
** MAII scorelog2(26/2400*10)=-3.20645087746743
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NRIP1 [Title/Abstract] AND ZNF573 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNRIP1(16437066)-ZNF573(38231095), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNRIP1

GO:0000122

negative regulation of transcription by RNA polymerase II

10364267

HgeneNRIP1

GO:0045944

positive regulation of transcription by RNA polymerase II

7641693|10364267

HgeneNRIP1

GO:0071392

cellular response to estradiol stimulus

15831516



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-5813-01ANRIP1chr21

16437066

-ZNF573chr19

38231095

-


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Fusion Gene ORF analysis for NRIP1-ZNF573

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000318948ENST00000339503NRIP1chr21

16437066

-ZNF573chr19

38231095

-
5UTR-3CDSENST00000318948ENST00000357309NRIP1chr21

16437066

-ZNF573chr19

38231095

-
5UTR-3CDSENST00000318948ENST00000392138NRIP1chr21

16437066

-ZNF573chr19

38231095

-
5UTR-3CDSENST00000318948ENST00000536220NRIP1chr21

16437066

-ZNF573chr19

38231095

-
5UTR-3CDSENST00000318948ENST00000590414NRIP1chr21

16437066

-ZNF573chr19

38231095

-
5UTR-3CDSENST00000400199ENST00000339503NRIP1chr21

16437066

-ZNF573chr19

38231095

-
5UTR-3CDSENST00000400199ENST00000357309NRIP1chr21

16437066

-ZNF573chr19

38231095

-
5UTR-3CDSENST00000400199ENST00000392138NRIP1chr21

16437066

-ZNF573chr19

38231095

-
5UTR-3CDSENST00000400199ENST00000536220NRIP1chr21

16437066

-ZNF573chr19

38231095

-
5UTR-3CDSENST00000400199ENST00000590414NRIP1chr21

16437066

-ZNF573chr19

38231095

-
5UTR-3CDSENST00000400202ENST00000339503NRIP1chr21

16437066

-ZNF573chr19

38231095

-
5UTR-3CDSENST00000400202ENST00000357309NRIP1chr21

16437066

-ZNF573chr19

38231095

-
5UTR-3CDSENST00000400202ENST00000392138NRIP1chr21

16437066

-ZNF573chr19

38231095

-
5UTR-3CDSENST00000400202ENST00000536220NRIP1chr21

16437066

-ZNF573chr19

38231095

-
5UTR-3CDSENST00000400202ENST00000590414NRIP1chr21

16437066

-ZNF573chr19

38231095

-
5UTR-3UTRENST00000318948ENST00000585724NRIP1chr21

16437066

-ZNF573chr19

38231095

-
5UTR-3UTRENST00000400199ENST00000585724NRIP1chr21

16437066

-ZNF573chr19

38231095

-
5UTR-3UTRENST00000400202ENST00000585724NRIP1chr21

16437066

-ZNF573chr19

38231095

-
5UTR-intronENST00000318948ENST00000480587NRIP1chr21

16437066

-ZNF573chr19

38231095

-
5UTR-intronENST00000400199ENST00000480587NRIP1chr21

16437066

-ZNF573chr19

38231095

-
5UTR-intronENST00000400202ENST00000480587NRIP1chr21

16437066

-ZNF573chr19

38231095

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for NRIP1-ZNF573


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for NRIP1-ZNF573


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:16437066/:38231095)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NRIP1

P48552

.
FUNCTION: Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function (By similarity). Plays a role in renal development (PubMed:28381549). {ECO:0000250|UniProtKB:Q8CBD1, ECO:0000269|PubMed:10364267, ECO:0000269|PubMed:11509661, ECO:0000269|PubMed:11518808, ECO:0000269|PubMed:12554755, ECO:0000269|PubMed:15060175, ECO:0000269|PubMed:21628546, ECO:0000269|PubMed:28381549, ECO:0000269|PubMed:7641693}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for NRIP1-ZNF573


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for NRIP1-ZNF573


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NRIP1-ZNF573


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NRIP1-ZNF573


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNRIP1C0006142Malignant neoplasm of breast1CTD_human
HgeneNRIP1C0014170Endometrial Neoplasms1CTD_human
HgeneNRIP1C0018801Heart failure1CTD_human
HgeneNRIP1C0018802Congestive heart failure1CTD_human
HgeneNRIP1C0023212Left-Sided Heart Failure1CTD_human
HgeneNRIP1C0027051Myocardial Infarction1CTD_human
HgeneNRIP1C0036341Schizophrenia1CTD_human
HgeneNRIP1C0235527Heart Failure, Right-Sided1CTD_human
HgeneNRIP1C0476089Endometrial Carcinoma1CTD_human
HgeneNRIP1C0678222Breast Carcinoma1CTD_human
HgeneNRIP1C1257931Mammary Neoplasms, Human1CTD_human
HgeneNRIP1C1458155Mammary Neoplasms1CTD_human
HgeneNRIP1C1959583Myocardial Failure1CTD_human
HgeneNRIP1C1961112Heart Decompensation1CTD_human
HgeneNRIP1C4704874Mammary Carcinoma, Human1CTD_human